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VAGKNRKRGQRAKKIATLSAATVTATALTAGIAPIGEANAAVVAREAALQADVRPFPPPDQIPDITGGLG AAGYDLAQAIGAQVMTSLMESISLAALAQAAGIDPQSIATGLLNEAIGSVLGGTLDQLPIDLTGVLQPLL AQVLTPLVSEILGELPIGGALGDALIGVVAGLVVSTLALELSDLGAIDNVGALLAALGLDLSNPLNLSGD PIPGLNLVTTGSPFTFLKLFGVDLGWVPPFPNPVAEDINNTEYLKVGLAGLLENLGIELDPIDLDILDLN LLGVDLSVLESVLDGLGLGLDLGNSGGLLGGLLGGLGLDLGLDLDALGLGTLDPNEILNLLPDVVALRIP IVVGFQLGAFAAGAAYQQVVDELPNQPGGANYQGTNPLLGSFTILPMVLIDNPGRANGGLFARAYPLFRL MGIDTVTPDTQVQSSTSGDSLLNNIQLLGLTVGGANLIPIKVDATAEYLPLSDFAAWPNPFTMTNNVAAA LFPTYILRNQSIPGVITDLTGQVVGQLLGDLADYVADPGDDPTKGPKLNIYYTLDAKSLPLLEPTYLAVD VINLFTGLNLNNPIGTALSPALTTLVNLGYTDVRRVETADGVEYVRDFDDSDIPTAFGSFPDVEWAKVPG DVVTQLVRGVQKAVGDGLVNQSPVPSPLTTLLGLLGLGNALPSGGSVLNLPDLNGLLPTAGTTNVAARQS EPNTKFEPQAITETKATDPDTTVLNLPSPQEKTTVPEPTKKVGGEVKKVVADIDEARAEIEAKVKKANER AKASAEKARERTQKAVKDAQDRVNKIADNGRKQIKAVADGVEKAVKDTKQAVKKATAKPTKKTQAGSQNN DNDKKDKDAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0200 | - | - | 100% (850) | hypothetical protein MSMEG_0200 |
| M. smegmatis MC2 155 | MSMEG_5421 | - | 4e-31 | 28.44% (531) | hypothetical protein MSMEG_5421 |
| M. smegmatis MC2 155 | MSMEG_0204 | - | 9e-29 | 45.56% (169) | hypothetical protein MSMEG_0204 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1828 | PPE28 | 2e-11 | 28.46% (267) | PPE family protein |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv1800 | PPE28 | 6e-12 | 28.84% (267) | PPE family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0370 | - | 1e-11 | 25.86% (379) | PE family protein |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_3772 | - | 1e-125 | 39.58% (897) | PUTATIVE putative AAA ATPase containing von Willebrand factor |
| M. ulcerans Agy99 | MUL_2440 | - | 2e-10 | 28.33% (233) | PPE family protein |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1828|M.bovis_AF2122/97 -----------MLPNFAVLPPEVNSARVFAGAGSAPMLAAAAAWDDLASE
Rv1800|M.tuberculosis_H37Rv -----------MLPNFAVLPPEVNSARVFAGAGSAPMLAAAAAWDDLASE
MUL_2440|M.ulcerans_Agy99 ------------------------------------MLAAAAAWDGTGQE
MMAR_0370|M.marinum_M -----------------------------------------------MSY
MSMEG_0200|M.smegmatis_MC2_155 MAGKNRKRGQRAKKIATL--SAATVTATALTAGIAPIGEANAAVVAREAA
TH_3772|M.thermoresistible__bu -MAKHTKTTRRSKKLATLGVATATATATALTVGAAPPEVETSALRNADVD
Mb1828|M.bovis_AF2122/97 LHCAAMSFG-----SVTSGLVVGWWQGSASAAMVDAAASYIGWLSTSAAH
Rv1800|M.tuberculosis_H37Rv LHCAAMSFG-----SVTSGLVVGWWQGSASAAMVDAAASYIGWLSTSAAH
MUL_2440|M.ulcerans_Agy99 LAAAASAFS-----SLTSDLAGAAWQGPSAAAMASVATSYVRWLGSAASG
MMAR_0370|M.marinum_M LLAEPELLA-----SVATEIDG---IGSAISTAGTAAAGPTSSLLAAAGD
MSMEG_0200|M.smegmatis_MC2_155 LQADVRPFPPPDQIPDITGGLGAAGYDLAQAIGAQVMTSLMESISLAALA
TH_3772|M.thermoresistible__bu LLAGIQFYPEPEHIPDLTFGLGAVGYGLSQDFAEMAIRGLVDNISFAALA
* . . : . : . . : :*
Mb1828|M.bovis_AF2122/97 AEGAAGLARAAVSVFEEALAATVHPAMVAANRAQVASLVASNLFGQNAPA
Rv1800|M.tuberculosis_H37Rv AEGAAGLARAAVSVFEEALAATVHPAMVAANRAQVASLVASNLFGQNAPA
MUL_2440|M.ulcerans_Agy99 AVQTARQVATSAAVFEAARTATVPLELVAANRSALMSMVAANVFGLNAPA
MMAR_0370|M.marinum_M EVSGA-----------------------------IANLFS--VYGRECQA
MSMEG_0200|M.smegmatis_MC2_155 QAAGIDPQSIATGLLNEAIGSVLG---GTLDQLP--IDLTGVLQPLLAQV
TH_3772|M.thermoresistible__bu EALGLDLQSQLENVLNNALAMLLGPVFGTLGQIPLDLDLVGLVGGLLDQK
. :
Mb1828|M.bovis_AF2122/97 IAALESLYEW-------MWAQDAAAMAGYYVGASAVATQLASWLQRLQSI
Rv1800|M.tuberculosis_H37Rv IAALESLYEC-------MWAQDAAAMAGYYVGASAVATQLASWLQRLQSI
MUL_2440|M.ulcerans_Agy99 IAAIEAQYEQ-------MWAQNVGAMFGYHVGVSEALSGLAPWQEVLSGV
MMAR_0370|M.marinum_M VLAQVEAFRS-------EFAQTLAAAGVAYAQTEAAS---------LAAL
MSMEG_0200|M.smegmatis_MC2_155 LTPLVSEILG-------ELP-IGGALGDALIGVVAG-----LVVSTLALE
TH_3772|M.thermoresistible__bu ITAELADTLRPVLEGLEDLPFLGSILGDILGPILGGNGNNGLVDMVLGEL
: . . . *
Mb1828|M.bovis_AF2122/97 PGAAS--------------------LDARLPSSAEAPMGVVRAVNSAIAA
Rv1800|M.tuberculosis_H37Rv PGAAS--------------------LDARLPSSAEAPMGVVRAVNSAIAA
MUL_2440|M.ulcerans_Agy99 SGRVA--------------------SALEGTSAAAAAALGPTALTAAGSA
MMAR_0370|M.marinum_M RGALG--------------------IPSAAP-----------AVSSASTI
MSMEG_0200|M.smegmatis_MC2_155 LSDLG---------AIDNVGALLAALGLDLSNPLNLSGDPIPGLNLVTTG
TH_3772|M.thermoresistible__bu LGDIIGGILPGAELDLDSLGGLLGLLGLDLSQPLNLS-NLNLGLNLVTTG
. . .:. . :
Mb1828|M.bovis_AF2122/97 NAAAAQTVGLVMGGSGTPIPSARYVELANALYMSGSVPGVIAQ-------
Rv1800|M.tuberculosis_H37Rv NAAAAQTVGLVMGGSGTPIPSARYVELANALYMSGSVPGVIAQ-------
MUL_2440|M.ulcerans_Agy99 LPAAATDVTLVIGGSGFPIPSQSYVDNVVNNFVTPNFPSFTVSNAI----
MMAR_0370|M.marinum_M PPFTANLTSLFLGPTGVPIPDESYVQAANNLFVR---SSDILR-------
MSMEG_0200|M.smegmatis_MC2_155 SPFTFLKLFGVDLGWVPPFPNPVAEDINNTEYLKVGLAGLLENLGIELDP
TH_3772|M.thermoresistible__bu PLFTALKLFGADLGWEPALPNAVAREINETEYLNVGLLSLLN--------
: .:*. : :: .
Mb1828|M.bovis_AF2122/97 -----------------------------------------------ALV
Rv1800|M.tuberculosis_H37Rv -----------------------------------------------ALF
MUL_2440|M.ulcerans_Agy99 -----------------------------------------------SLF
MMAR_0370|M.marinum_M -----------------------------------------------PLY
MSMEG_0200|M.smegmatis_MC2_155 IDLDILDLNLLGVDLSVLESVLDGLGLGLDLGNSGGLLGGLLGGLGLDLG
TH_3772|M.thermoresistible__bu -----------------------------------------------TLG
*
Mb1828|M.bovis_AF2122/97 TPQGLYPVVVIKNLTFDSSVAQGAVILESAIRQQIAA-GNNVTVFGYSQS
Rv1800|M.tuberculosis_H37Rv TPQGLYPVVVIKNLTFDSSVAQGAVILESAIRQQIAA-GNNVTVFGYSQS
MUL_2440|M.ulcerans_Agy99 TPAESYWITGIKTMTEDASWAEGLTILDTAIKAQLAA-GNNVVVQGYSQG
MMAR_0370|M.marinum_M TPEELYPLTGVKSLTLNASVEEGLTILDNAIMAQLSIPGNSVTVFGYSQS
MSMEG_0200|M.smegmatis_MC2_155 LDLDALGLGTLDPNEILNLLPDVVALRIPIVVGFQLGAFAAGAAYQQVVD
TH_3772|M.thermoresistible__bu LEDLSAALGDLP---IVGDLPDLIALRVPIVIGVGLGAFAAGAAYNQVVA
: : : .: : ..
Mb1828|M.bovis_AF2122/97 ATISSLVMANLAASAD-PPSPDELSFTLIGNPNNPNGGVATRFPGIS---
Rv1800|M.tuberculosis_H37Rv ATISSLVMANLAASAD-PPSPDELSFTLIGNPNNPNGGVATRFPGIS---
MUL_2440|M.ulcerans_Agy99 AGIASLEMSNLKAAGV-PTG--SVSFSLIGNAMNPNGGLYERFAGLV---
MMAR_0370|M.marinum_M AIIASLEMQKLAALGPSAPTASQLNFVLVGNEMNPNGGMLARFPDLS---
MSMEG_0200|M.smegmatis_MC2_155 ELPNQPGGANYQGTNPLLGSFTILPMVLIDNPGRANGGLFARAYPLFRLM
TH_3772|M.thermoresistible__bu DLANQPGGVN--GAESLLGSYTILPMILLRNPGRANGGLFARMYPLAGLF
. : . : : *: * ..***: * :
Mb1828|M.bovis_AF2122/97 -----FPSLGVTATG--------------ATP-HNLYPTKIYT-IEYDGV
Rv1800|M.tuberculosis_H37Rv -----FPSLGVTATG--------------ATP-HNLYPTKIYT-IEYDGV
MUL_2440|M.ulcerans_Agy99 -----SPSLGKTFWG--------------ATP-DNYYTTDVYT-LEYDGF
MMAR_0370|M.marinum_M -----LPSLGLTFYG--------------ATPSDTIYPTAIYT-LEYDGF
MSMEG_0200|M.smegmatis_MC2_155 GIDTVTPDTQVQSSTSGDSLLNNIQLLGLTVGGANLIPIKVDATAEYLPL
TH_3772|M.thermoresistible__bu GIDTVTPETSAQSSGGTVPVLG----TGLTVGGANLIPVKIDATAEYDFL
*. :. . . : : ** .
Mb1828|M.bovis_AF2122/97 ADFPRYPLNFVSTLNAIAGTYYVHSNYFILTPEQIDAAVPLTN-------
Rv1800|M.tuberculosis_H37Rv ADFPRYPLNFVSTLNAIAGTYYVHSNYFILTPEQIDAAVPLTN-------
MUL_2440|M.ulcerans_Agy99 ADFPRYPPNFVSDLNAIMGIYYVHTQYPTLTAAQVATAFTLP--------
MMAR_0370|M.marinum_M ADFPRYPLNFIADLNAVMGIPFVHVKYLDLTAAQVDSAIELPT-------
MSMEG_0200|M.smegmatis_MC2_155 SDFAAWPNPFTMTNNVAAALFPTYILRNQSIPGVITDLTGQVVGQLLGDL
TH_3772|M.thermoresistible__bu SDFAAWPNPFSMANNVAALLFPTYLLRGLSALDLVDSLGEQLTPQLAQIL
:**. :* * *. .: :
Mb1828|M.bovis_AF2122/97 ----------TVGPT-MTQYYIIRTENLPLLEPLRSVP----------IV
Rv1800|M.tuberculosis_H37Rv ----------TVGPT-MTQYYIIRTENLPLLEPLRSVP----------IV
MUL_2440|M.ulcerans_Agy99 ----------TEGAT-MTTYHMIPTENLPLLEPLRGVP----------FI
MMAR_0370|M.marinum_M ----------SPGYSGVTSYYVIPTENLPLLEPLRAIP----------VI
MSMEG_0200|M.smegmatis_MC2_155 ADYVADPGDDPTKGPKLNIYYTLDAKSLPLLEPTYLAVDVINLFT-GLNL
TH_3772|M.thermoresistible__bu DNVLQ-----LDEALAINLYLTLPMNTLPLLEPLYLATDFINLFTPGFDV
:. * : :.****** :
Mb1828|M.bovis_AF2122/97 GNPLANLVQPNLKVIVNLGYGDP---------AYGYSTSPPNVATPFGLF
Rv1800|M.tuberculosis_H37Rv GNPLANLVQPNLKVIVNLGYGDP---------AYGYSTSPPNVATPFGLF
MUL_2440|M.ulcerans_Agy99 GNTLADLVQPDLKVLVNLGYGDP---------NYGYSTGPANVPTPFGLF
MMAR_0370|M.marinum_M GNPLANLIQPDLKVIVNLGYGDP---------NYGYSTSYADVRTPFGLF
MSMEG_0200|M.smegmatis_MC2_155 NNPIGTALSPALTTLVNLGYTDVRRVETADGVEYVRDFDDSDIPTAFGSF
TH_3772|M.thermoresistible__bu NNPIATALNPVLTSLVNLGYTDVYWDDAKG--QYDRTLLEADIPTGFGTL
.*.:. :.* *. :***** * * .:: * ** :
Mb1828|M.bovis_AF2122/97 P-----EVSPVVIADALAAGTQQGIGDFAYDVSHLELP-LPADGSTMPST
Rv1800|M.tuberculosis_H37Rv P-----EVSPVVIADALVAGTQQGIGDFAYDVSHLELP-LPADGSTMPST
MUL_2440|M.ulcerans_Agy99 P-----DVAPATVFDALVAGTQQGISDAAADIGAWQLPSLPDISLSGISN
MMAR_0370|M.marinum_M P-----DVSPGTIVDALAAGTQEGIQDFTADLQAMFGQPIPTPDIVPP--
MSMEG_0200|M.smegmatis_MC2_155 P-DVEWAKVPGDVVTQLVRGVQKAVGDGLVNQSPVPSPLTTLLGLLGLGN
TH_3772|M.thermoresistible__bu PADVNWLEVPGNLFASLMRGVQDAFEEGLIGPE-GSNVLRTLLGLIGLDL
* * : * *.*... : . . .
Mb1828|M.bovis_AF2122/97 APGS-------GTPVPPLS-------IDSLIDDLQVANRNLANTISKVAA
Rv1800|M.tuberculosis_H37Rv APGS-------GTPVPPLS-------IDSLIDDLQVANRNLANTISKVAA
MUL_2440|M.ulcerans_Agy99 ALGSDPWSALSNATLPTLSVST----IENAIKGVQTATTDIANTISFDAT
MMAR_0370|M.marinum_M ------------TPADILG----------KLSELPSP-AQVVNTLTAVVA
MSMEG_0200|M.smegmatis_MC2_155 ----ALPSGGSVLNLPDLN---------GLLPTAGTTNVAARQSEPNTKF
TH_3772|M.thermoresistible__bu GGLGAGAAGLSMDGLPELLRDAVEDAVGGLGELGGVSPLSSSQPEAAAVP
* . :. .
Mb1828|M.bovis_AF2122/97 TSYATVLPTADIANAALTIVPSYNIHLFLEGIQQALKGDPMGLVNAVG--
Rv1800|M.tuberculosis_H37Rv TSYATVLPTADIANAALTIVPSYNIHLFLEGIQQALKGDPMGLVNAVG--
MUL_2440|M.ulcerans_Agy99 TAYATLLPTADVVNAMVTTLPAYNLKLFLDGILQVLDGDPAGLIYALG--
MMAR_0370|M.marinum_M NDYAVLLPTADIGLAVVTTLPLYSTQLFFD---QLLQGN---LIDAFG--
MSMEG_0200|M.smegmatis_MC2_155 EPQAITETKATDPDTTVLNLPSPQEKTTVPEPTKKVGGEVKKVVADIDEA
TH_3772|M.thermoresistible__bu DLGADTLTLKTGQRAAALNESDGAGLKENSEQPQDAAGEKTVIDTSTGDE
* . : . : *: : .
Mb1828|M.bovis_AF2122/97 -----------------------------------YPLAADVALFTAAGG
Rv1800|M.tuberculosis_H37Rv -----------------------------------YPLAADVALFTAAGG
MUL_2440|M.ulcerans_Agy99 -----------------------------------APIAADTALVTLLAG
MMAR_0370|M.marinum_M -----------------------------------YPIAATVGLLTIGGA
MSMEG_0200|M.smegmatis_MC2_155 RAEIEAKVKKANERAKAS-----AEKARERTQKAVKDAQDRVNKIADNGR
TH_3772|M.thermoresistible__bu SPQPTPDAPREDAIKPPSSKLRTGSNGRGEVRTGLGAPGKHLQQSTERLG
:
Mb1828|M.bovis_AF2122/97 LQLLIIISAGRTIANDISAIVP----------------------------
Rv1800|M.tuberculosis_H37Rv LQLLIIISAGRTIANDISAIVP----------------------------
MUL_2440|M.ulcerans_Agy99 FNLYAYLYAFNKILPGVL--------------------------------
MMAR_0370|M.marinum_M VEFLTIAAAAQTTVQDIGSLIP----------------------------
MSMEG_0200|M.smegmatis_MC2_155 KQIKAVADGVEKAVKDTKQAVKK-ATAKPTKKTQAGSQNNDNDKK-----
TH_3772|M.thermoresistible__bu QRLQDRADKINDGLRNAGAGLRNGLTAGPSSKSQPKSQPKTAAKVGAGVG
.: . .
Mb1828|M.bovis_AF2122/97 -----------
Rv1800|M.tuberculosis_H37Rv -----------
MUL_2440|M.ulcerans_Agy99 -----------
MMAR_0370|M.marinum_M -----------
MSMEG_0200|M.smegmatis_MC2_155 ---DKDAA---
TH_3772|M.thermoresistible__bu ATSDSESGGDE