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M. thermoresistible (build 8) TH_3597 (-)

annotation: putative aminoglycoside phosphotransferase
coordinates: 3853901 - 3855022
length: 374

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3597--100% (374)putative aminoglycoside phosphotransferase
M. thermoresistible (build 8)TH_2511-7e-4235.38% (359) PUTATIVE protein of unknown function DUF227
M. thermoresistible (build 8)TH_0441-6e-4133.97% (365) phosphotransferase enzyme family protein, putative

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97-----
M. gilvum PYR-GCKMflv_3155-7e-3935.38% (359) hypothetical protein Mflv_3155
M. tuberculosis H37Rv-----
M. leprae Br4923-----
M. abscessus ATCC 19977-----
M. marinum MMMAR_4035-2e-3731.02% (361) hypothetical protein MMAR_4035
M. avium 104MAV_1568-5e-3631.51% (365) phosphotransferase enzyme family protein, putative
M. smegmatis MC2 155MSMEG_3876-4e-3832.96% (358) phosphotransferase enzyme family protein, putative
M. ulcerans Agy99MUL_1045-1e-1630.40% (329) hypothetical protein MUL_1045
M. vanbaalenii PYR-1Mvan_3374-3e-3934.54% (359) aminoglycoside phosphotransferase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3155|M.gilvum_PYR-GCK          --MADRPLLYLGRVCSLTRPQLIERPADLTAEWLTDILGHG----QVESF
Mvan_3374|M.vanbaalenii_PYR-1       -----------------MRPRLIERPPDLTAEWLTAVIGQG----TVTEF
TH_3597|M.thermoresistible__bu      --------------MEKRRALGPTTADEVTAEWLTGCLRAAGHDVDVLNF
MMAR_4035|M.marinum_M               ------------------MVSIPRHPTDVTPQWLAAVLGERGTPVGVSGV
MAV_1568|M.avium_104                ------------------MLSIPRYPGDVTPQWLSAALSGRGAPVEVAEV
MSMEG_3876|M.smegmatis_MC2_155      ---------------MTAAVSIPGRPVDVTPSWLSGVLG-----TEVATA
MUL_1045|M.ulcerans_Agy99           MIALARLATHLGRGLGRVATDAVLRNARAFPRRIHDLDPPALSEIMGRRV
                                                                  .  :                

Mflv_3155|M.gilvum_PYR-GCK          TVDRIGTGQMSECYRVGIRYAGGG-VGPASVVLKVAAAEPSSRQTG----
Mvan_3374|M.vanbaalenii_PYR-1       TVDRIGTGQMSECYRVALSYADDG-AGPATVVLKVAAADPSSRQTG----
TH_3597|M.thermoresistible__bu      RGEPIGNGMMAAAQRLTLTLSGDDESAPKTLVLKYATEGAASRHTGRRGF
MMAR_4035|M.marinum_M               DVVPIGTGQTGATYRLTVIYDPDPAGLPDTFVIKLPAQDDTVRDRVVVG-
MAV_1568|M.avium_104                DVAAIGTGQTGATYRVTARYATDPGDLPQTFVIKLPAQDDTVRDRVVIG-
MSMEG_3876|M.smegmatis_MC2_155      ATEPIGTGQTGATYRVTVTYAGDS-ALPTTFAIKLPSQDDTVRDRVAIG-
MUL_1045|M.ulcerans_Agy99           SSVSVLDDSSGTTSRARLALSGND--VPESVFVKMAAATAATRFIGELG-
                                        :  .  .   *       .    * :. :* .:   : *       

Mflv_3155|M.gilvum_PYR-GCK          ---LAMGLYEREVRFYTDIAPSLGGPVAPCHHTAYDPDTGAFDLVLADAA
Mvan_3374|M.vanbaalenii_PYR-1       ---LAMGLYEREVRFYTDIAPGLGGPVAPCHHGAYDPHTGAFDLLLADAA
TH_3597|M.thermoresistible__bu      GFPNRPGFYEQEVRFYRDFAARLDVRVPKSYAEWIAPEGDRFVLLLEDIV
MMAR_4035|M.marinum_M               --------YRSECAFYSSVADRVRVPTPRCFYCEITEDAMDFALLLEDQA
MAV_1568|M.avium_104                --------YRSECAFYSSVADRVQVPTPRCFYSEITEDAMDFALLLADQA
MSMEG_3876|M.smegmatis_MC2_155      --------YRSEHAFYTSLAGQVRIPVPHCYHCEIAGEGADFVLVLADMA
MUL_1045|M.ulcerans_Agy99           ------RLAETEVSFYRDLSPELAPDAPTAYGCAFDPLTGRFVLVLEDLA
                                             . *  ** ..:  :   .. ..          * *:* * .

Mflv_3155|M.gilvum_PYR-GCK          PASVG-----DEIRGATAEQASLAMTQLGLVHGPLLGSEALEG--ADWLN
Mvan_3374|M.vanbaalenii_PYR-1       PALVG-----DEIRGATVEEAMLAVTQIGLVHGPLLNDEALAG--ADWLN
TH_3597|M.thermoresistible__bu      PASPG-----DEFATPQPAELHGAMVNLAGLHAPLWNGPFPPG--DNLLK
MMAR_4035|M.marinum_M               PAVQG-----DQLTGCGEREARLAVVALAGLHGPSWCDPVWLDQPGIAFP
MAV_1568|M.avium_104                PAVQG-----DQLLGCGETEARLAVTALAGLHAPSWCDPVWLDFPGIAFG
MSMEG_3876|M.smegmatis_MC2_155      PAEQG-----DQIAGCSPAEAALAVRALADLHGPTWCDPQWANFPGIAMP
MUL_1045|M.ulcerans_Agy99           APAEGTCDFSDTLHPFDNDQAALVVELLARLHATYWVRLNHGG--VRPFG
                                    ..  *     * :      :   .:  :. :*..        .     : 

Mflv_3155|M.gilvum_PYR-GCK          RESPVNQGLVAALYAGYIDRYSDQIAPEHRVVCERLVASFDAYMAAEDAA
Mvan_3374|M.vanbaalenii_PYR-1       RESPVNQGLISALYAGYIDRYREQIAPEHRNVCERFVESFDAYMAAENDA
TH_3597|M.thermoresistible__bu      PPSAVEGARYQRITQRNIDHFRNVMAVEPGSATDRVLGRFVERADRWWVA
MMAR_4035|M.marinum_M               FPDEPFANGLGEVARMSAEITLDKLGDRLSAADRETFTETMNLVTPWLLA
MAV_1568|M.avium_104                RPDEAGAGGMGEVAKMSADITLERLGDRMSAEDRETFAAAMGVIAPWLLS
MSMEG_3876|M.smegmatis_MC2_155      KPEPDSAKGFGDIAKMAADITLDKLGDRLSIGDRETLSASMSVVTPWLLA
MUL_1045|M.ulcerans_Agy99           WRYAASRDPSVPLVPTMLRASWRRLGGHAAALLPGRDFVFEHYRAITGLI
                                                :           :. .                      

Mflv_3155|M.gilvum_PYR-GCK          GG-PRGLVHGDFRLDNMLFGQDGSDRPLTVVDWQTVTWGPAFTDVSYFLG
Mvan_3374|M.vanbaalenii_PYR-1       DT-PRGLVHGDYRLDNMLFGQDGAHRPLTVVDWQTVTWGPAFSDVAYFLG
TH_3597|M.thermoresistible__bu      AGRPHGLVHGDYRPDNMLFPVHDGARP-VVVDWQTVSVAHTGRDLGGFLG
MMAR_4035|M.marinum_M               ERDRFALLHGDYRLDNLLFDPD--LRRVAVVDWQTLGIGLPARDLGYFTA
MAV_1568|M.avium_104                EYDRFALLHGDYRLDNLLFDPD--RTRVSVVDWQTLGVGLPARDLAYFTA
MSMEG_3876|M.smegmatis_MC2_155      EPDRFAVLHGDYRLDNMLFDPD--RTRVTVVDWQTLGSGLPARDLSYFTA
MUL_1045|M.ulcerans_Agy99           DAPPHTVLHGDAHPGNWYFRSSGGPLAAGLLDWQAIRLGHPARDLAYTLI
                                          ::*** : .*  *          ::***::  . .  *:.    

Mflv_3155|M.gilvum_PYR-GCK          GSLPIEERRAHYDELLAAYHRALGEA--TGVSLDDVREGVRHQSFFGVLM
Mvan_3374|M.vanbaalenii_PYR-1       CALPVEQRREHYDALLAAYHGALGPT--AGVSIDEVREGVRRQSFFGVLM
TH_3597|M.thermoresistible__bu      ASTPTEVRREHEHELLRTYHRRLIQLGVQGYSEEDCRSDLRLGVFHGLQN
MMAR_4035|M.marinum_M               TSLNSQLRSDIEESLVDDYHRKLLSYGVTGYDWETCWRDYRLGMPHTVLI
MAV_1568|M.avium_104                TSLDSPLRAAIEEELVADYHRALVAGGVNGYDRETCWRDYRLGVLQAPLI
MSMEG_3876|M.smegmatis_MC2_155      TSLDPADRAAAERDLVGEYHRTLLAHGVTGYDRETCWRDYRLGMLQAPLI
MUL_1045|M.ulcerans_Agy99           TGMTTTDRRVTERELLDVYRRALAAAGGPELDREEPWLRYRQAAACAYVA
                                     .     *      *:  *:  *        . :      *         

Mflv_3155|M.gilvum_PYR-GCK          AIVSSMLVGRTERGDEMFMALIARHCQHVLDTDALAILPAPSTPEPLQPN
Mvan_3374|M.vanbaalenii_PYR-1       SIVSPMLVERTERGDEMFMAMIARHCQHVIDTGALAVLPEPGTPEPLQPN
TH_3597|M.thermoresistible__bu      TVAIARAVDMNDRGWQLVRTWLDRLLAAFDDLDSLDALDELEALS-----
MMAR_4035|M.marinum_M               SALGFAFATATERGDEMVLTMLGRGCQAIRDLETLELIG-----------
MAV_1568|M.avium_104                SALGFAFAAATERGDDMVLTMLGRGCRAIRELGTLELIG-----------
MSMEG_3876|M.smegmatis_MC2_155      TVLGCAFASSTDRGDDMMVVMAQRGCQAIRELGTLDLIDAAS--------
MUL_1045|M.ulcerans_Agy99           TTIAAGLGG--MQAADIALTGLDLTVAALHDLQTVAALRAADLGGTSWAW
                                    :           :. ::  .        . :  ::  :            

Mflv_3155|M.gilvum_PYR-GCK          ADDEGRHAPTEEPLWSESWYFDFAAPSQDIGGWIRLGLMPNEGHAWVNGL
Mvan_3374|M.vanbaalenii_PYR-1       ADDEGRHSPTDEALWSESWYFDFADPGQQLGGWIRLGLIPNQDHAWINGL
TH_3597|M.thermoresistible__bu      --------------------------------------------------
MMAR_4035|M.marinum_M               --------------------------------------------------
MAV_1568|M.avium_104                --------------------------------------------------
MSMEG_3876|M.smegmatis_MC2_155      --------------------------------------------------
MUL_1045|M.ulcerans_Agy99           RPGMARSARIRPGASARRCPMVWSTSSHILGVSRHFAMGAW---------
                                                                                      

Mflv_3155|M.gilvum_PYR-GCK          LCGPGMPTIAALDFEAPLPEEHTRVHGQDIELEQTVIEPLQTYQVTVRGR
Mvan_3374|M.vanbaalenii_PYR-1       WCAPGGPTIAVLDFEAPLPEDHTHVAADGIELDLEVLEPLSSYRVVLRGR
TH_3597|M.thermoresistible__bu      --------------------------------------------------
MMAR_4035|M.marinum_M               --------------------------------------------------
MAV_1568|M.avium_104                --------------------------------------------------
MSMEG_3876|M.smegmatis_MC2_155      --------------------------------------------------
MUL_1045|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

Mflv_3155|M.gilvum_PYR-GCK          GQAHDDPAALLRGEPGRDVEVTMDLTWTSVGQPYQYRVSPRYEIPCTVTG
Mvan_3374|M.vanbaalenii_PYR-1       GEAHDDPAALLRGEAGRPVDVSMDLTWSTVGRPYQYRMSPRYEIPCTVTG
TH_3597|M.thermoresistible__bu      --------------------------------------------------
MMAR_4035|M.marinum_M               --------------------------------------------------
MAV_1568|M.avium_104                --------------------------------------------------
MSMEG_3876|M.smegmatis_MC2_155      --------------------------------------------------
MUL_1045|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

Mflv_3155|M.gilvum_PYR-GCK          TVSADGHTYEFDAVVGQRDHSWAARDWWAMDWVWSAFHLEDGTHIHGVEI
Mvan_3374|M.vanbaalenii_PYR-1       TVVADGRTYAIAGVPGQRDHSWAARDWWSMDWMWSALHLDDGTHIHGVEI
TH_3597|M.thermoresistible__bu      --------------------------------------------------
MMAR_4035|M.marinum_M               --------------------------------------------------
MAV_1568|M.avium_104                --------------------------------------------------
MSMEG_3876|M.smegmatis_MC2_155      --------------------------------------------------
MUL_1045|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

Mflv_3155|M.gilvum_PYR-GCK          LIPGAPPMSIGYLQRAGEPLVELSSVSAQTTFADNDLPQSAVLDYG--DL
Mvan_3374|M.vanbaalenii_PYR-1       LIPGMPPLAVGYVQRDGESLVELAKVSARTTFADNGLPISAQVDYAPGDI
TH_3597|M.thermoresistible__bu      --------------------------------------------------
MMAR_4035|M.marinum_M               --------------------------------------------------
MAV_1568|M.avium_104                --------------------------------------------------
MSMEG_3876|M.smegmatis_MC2_155      --------------------------------------------------
MUL_1045|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

Mflv_3155|M.gilvum_PYR-GCK          RVDVTVRGHAPVLLTSADGRLSQFPRAWATVTTDDGRTGAGWIEWNRNLA
Mvan_3374|M.vanbaalenii_PYR-1       TATIDVRGHAPVLLTSPDGRHSRFPRAWGEVTTADGRTGVGWIEWNRSQD
TH_3597|M.thermoresistible__bu      --------------------------------------------------
MMAR_4035|M.marinum_M               --------------------------------------------------
MAV_1568|M.avium_104                --------------------------------------------------
MSMEG_3876|M.smegmatis_MC2_155      --------------------------------------------------
MUL_1045|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

Mflv_3155|M.gilvum_PYR-GCK          QPDG
Mvan_3374|M.vanbaalenii_PYR-1       ----
TH_3597|M.thermoresistible__bu      ----
MMAR_4035|M.marinum_M               ----
MAV_1568|M.avium_104                ----
MSMEG_3876|M.smegmatis_MC2_155      ----
MUL_1045|M.ulcerans_Agy99           ----