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aa seq not available
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. thermoresistible (build 8) | TH_3022 | - | - | 100% (1283) | acyl transferase domain protein |
M. thermoresistible (build 8) | TH_4621 | - | 3e-41 | 33.26% (433) | PUTATIVE mycocerosic acid synthase |
M. thermoresistible (build 8) | TH_4178 | - | 5e-35 | 28.48% (453) | PUTATIVE mycolic acid condensase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2402c | mbtD | 0.0 | 53.36% (744) | polyketide synthetase MBTD (polyketide synthase) |
M. gilvum PYR-GCK | Mflv_4666 | - | 0.0 | 50.62% (883) | UvrD/REP helicase |
M. tuberculosis H37Rv | Rv2381c | mbtD | 0.0 | 53.36% (744) | polyketide synthetase MBTD (polyketide synthase) |
M. leprae Br4923 | MLBr_02356 | - | 1e-47 | 25.90% (726) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_3516c | - | 1e-157 | 43.20% (845) | ATP-dependent DNA helicase |
M. marinum M | MMAR_1358 | - | 0.0 | 58.10% (611) | ATP-dependent DNA helicase |
M. avium 104 | MAV_4148 | - | 0.0 | 59.65% (622) | helicase, UvrD/Rep family protein |
M. smegmatis MC2 155 | MSMEG_1941 | - | 0.0 | 65.97% (623) | helicase, UvrD/Rep family protein |
M. ulcerans Agy99 | MUL_2521 | - | 0.0 | 57.77% (611) | ATP-dependent DNA helicase |
M. vanbaalenii PYR-1 | Mvan_1801 | - | 0.0 | 53.04% (873) | UvrD/REP helicase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_4666|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1801|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_1941|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_1358|M.marinum_M -------------------------------------------------- MUL_2521|M.ulcerans_Agy99 -------------------------------------------------- MAV_4148|M.avium_104 -------------------------------------------------- MAB_3516c|M.abscessus_ATCC_199 -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 MRTAFSRISGMTTQQRAALIEEFTKLSRIAVAEPIAVVGIGCRFPGDVTG Mflv_4666|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1801|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_1941|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_1358|M.marinum_M -------------------------------------------------- MUL_2521|M.ulcerans_Agy99 -------------------------------------------------- MAV_4148|M.avium_104 -------------------------------------------------- MAB_3516c|M.abscessus_ATCC_199 -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 PDSFWDLLIDGRNAISRVPADRWDADAFYDPDPLTPGRMTTKWGGFVSDI Mflv_4666|M.gilvum_PYR-GCK --------------------------------------MSAPQTELTTDA Mvan_1801|M.vanbaalenii_PYR-1 --------------------------------------MSAPHTELSPEA MSMEG_1941|M.smegmatis_MC2_155 -----------------------------------MTTRPAESAPQTAST MMAR_1358|M.marinum_M ---------------------------------------MSLSWGAEARE MUL_2521|M.ulcerans_Agy99 ---------------------------------------MSLSWGAEARE MAV_4148|M.avium_104 ---------------------------------------MSFTWDAQAGA MAB_3516c|M.abscessus_ATCC_199 ---------------------------------MSAPPPSSRYWDGAAAC TH_3022|M.thermoresistible__bu -------------------------MTPITRANSWPDGRIPVLLSAHAED Mb2402c|M.bovis_AF2122/97 -------------------------------------MAPKQLPDGRVAV Rv2381c|M.tuberculosis_H37Rv -------------------------------------MAPKQLPDGRVAV MLBr_02356|M.leprae_Br4923 AGFDAAFFGITPREAAAMDPQQRILLEVAWEALENAGIPPDSLGNSRTGV Mflv_4666|M.gilvum_PYR-GCK LGRRDLRGTVRVLGGPGTGKSSLLVDTAVAHIAAGCDPESVLLLTGSARL Mvan_1801|M.vanbaalenii_PYR-1 LSRRDVRGTVRVLGGPGTGKSSLLVDTAAAHIAAGCDPESVLLLTGSSRL MSMEG_1941|M.smegmatis_MC2_155 LLEPGSNGVVRLLGGPGTGKSSLLVDTAVQHILAGADPESVLLLTGSARL MMAR_1358|M.marinum_M LLTPGSRGLVRVLGGPGTGKSALLVQAAIAHIAAGADPESVLLLTGSGRM MUL_2521|M.ulcerans_Agy99 LLTPGSRGLVRVLGGPGTGKSALLVQAAIAHIAAGADPESVLLLTGSGRM MAV_4148|M.avium_104 VLAPGAHGTVRVLGGPGTGKSSLLVDAAVAQIEAGVNPESVLLLTGSGRL MAB_3516c|M.abscessus_ATCC_199 LLDPDRTGRFVVVGGSGTGKTSLLVDIVAAHTAAGVNPASVLVLTGSNRA TH_3022|M.thermoresistible__bu LLRADARALLDYLDREPAAAVXXXXRAVIRAADRTELADGLRAVADGAEH Mb2402c|M.bovis_AF2122/97 LLSAHAEELIGPDARAIADYLERFPATTVTEVARQLR-KTRRVRRHRAVL Rv2381c|M.tuberculosis_H37Rv LLSAHAEELIGPDARAIADYLERFPATTVTEVARQLR-KTRRVRRHRAVL MLBr_02356|M.leprae_Br4923 MIGVYFNEYQSMLASSLENVDAYSGTGNAHSITVGRISYLLGLRGPSLAV : Mflv_4666|M.gilvum_PYR-GCK SVQVRASITSALLGAG-------GRAAVREPLVRTVHSYAFGVLRLAAQR Mvan_1801|M.vanbaalenii_PYR-1 SAQARAAITTALLGAG-------ARSAVREPLVRTVHSYAFAVLRLAAQR MSMEG_1941|M.smegmatis_MC2_155 RTAARAAITARLLGAG-------TVGVVREPLVRTVHSYAFAVLRLAAQR MMAR_1358|M.marinum_M GMWARSSLTTALLRSHTTG---TGRAAVREPLVRSVHSYAYAVLRRAAER MUL_2521|M.ulcerans_Agy99 GMRARSSLTTALLRSHTTG---TGRAAVREPLVRSVHSYAYAVLRRAAER MAV_4148|M.avium_104 PMAERSALTTALLRSAGAG---P---AVREPLVRTVHGYAYAVLRRAAER MAB_3516c|M.abscessus_ATCC_199 SAELRNRISAAVFERCAG-------VAIREPMVRTVHSYAFAVLAAHAAC TH_3022|M.thermoresistible__bu RLVARSDHSTAPRLAFVFPGQGSQWPGMGAAAYRQFAEYRAGVDACAAAF Mb2402c|M.bovis_AF2122/97 RAADRLELAEGLRALAAGR----EHPLIARSSLGSAPRQAFVFPGQGGHW Rv2381c|M.tuberculosis_H37Rv RAADRLELAEGLRALAAGR----EHPLIARSSLGSAPRQAFVFPGQGGHW MLBr_02356|M.leprae_Br4923 DTACSSSLVAVHLACQSLRLRETDLVLAGGVSITLRPETQIAISAWGLLS . Mflv_4666|M.gilvum_PYR-GCK NGS---PPPRLITSAE--------------------------QDGIIREL Mvan_1801|M.vanbaalenii_PYR-1 NGS---PPPRLITSAE--------------------------QDGIIREL MSMEG_1941|M.smegmatis_MC2_155 NGD---PPPRLITSAE--------------------------QDGIIREL MMAR_1358|M.marinum_M TGD---APPRLLTSAE--------------------------QDAIIREL MUL_2521|M.ulcerans_Agy99 TGD---APPRLLTSAE--------------------------QDAIIREL MAV_4148|M.avium_104 AGE---APPRLVTSAE--------------------------QDAIIREL MAB_3516c|M.abscessus_ATCC_199 QGN---PPPRLITAAE--------------------------QDSIVREL TH_3022|M.thermoresistible__bu TAAGAPAPLRYLTTPDDPESFCETEVEGAQFTHAVALARMWRHHGVLPDI Mb2402c|M.bovis_AF2122/97 PGMG---------------------------------------AVAYREL Rv2381c|M.tuberculosis_H37Rv PGMG---------------------------------------AVAYREL MLBr_02356|M.leprae_Br4923 PHGRCAAFDAAADGFVRGEG---------------------AGVVVLKRL : Mflv_4666|M.gilvum_PYR-GCK LAG-DVEDGPASPVRWPEQLRPALSTVG-FATELRDLMAR---CSERGID Mvan_1801|M.vanbaalenii_PYR-1 LAG-DVEDGDASPVRWPERLRPALSTVG-FATELRDLMAR---CSERGVD MSMEG_1941|M.smegmatis_MC2_155 LAG-DLEDGHRSPVGWPEQLWPALTTAG-FATELRDLMAR---CTERGVD MMAR_1358|M.marinum_M LAG-DLEDGPSARSAWPRHLLPALTTAG-FATELRNLLAR---CAERGVD MUL_2521|M.ulcerans_Agy99 LAG-DLEDGPSAGSAWPRHLLPALTTAG-FATELRNLLAR---CAERGVD MAV_4148|M.avium_104 LAG-DLADGPRAATAWPAALRPALSTAG-FATELRNLLAR---CAERGVD MAB_3516c|M.abscessus_ATCC_199 LCG-NAEDNSGS---WPASLRPALATAG-FATGVRDLMAR---CTERGVD TH_3022|M.thermoresistible__bu TVGHSLGEVGAAYIAGAITLADAVSVVI-ARAGVVDRLPGRYAVAVLGVD Mb2402c|M.bovis_AF2122/97 PTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVH Rv2381c|M.tuberculosis_H37Rv PTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVH MLBr_02356|M.leprae_Br4923 TDAVRDGDLVLAVVRGSAVNQDGRSNGVTAPNTAAQCDVITDALRSSDVA : : . : : Mflv_4666|M.gilvum_PYR-GCK PVALQRIGRHA---------GRPEWQAAG-----------------RFAQ Mvan_1801|M.vanbaalenii_PYR-1 PLALQRIGRAA---------GRPEWQAAG-----------------RFAQ MSMEG_1941|M.smegmatis_MC2_155 PIALQRLGRTA---------KRPEWLAAG-----------------RFAQ MMAR_1358|M.marinum_M PMELERLGRRS---------GRPEWAAAG-----------------RFAR MUL_2521|M.ulcerans_Agy99 PMELERLGRRS---------GRPEWAAAG-----------------RFAR MAV_4148|M.avium_104 PQALERLGRRC---------RRPEWVAAG-----------------QFAR MAB_3516c|M.abscessus_ATCC_199 ARELRAIGRRH---------NRPEWIAVA-----------------GLAR TH_3022|M.thermoresistible__bu ADAARDVIASTPGWLELSVVNAPSSVAVSGDRDAVSAAVARVREQGRFAR Mb2402c|M.bovis_AF2122/97 AVALAEVWRSCG--------VLPDLTVGHSLG--------------EVAA Rv2381c|M.tuberculosis_H37Rv AVALAEVWRSCG--------VLPDLTVGHSLG--------------EVAA MLBr_02356|M.leprae_Br4923 PESVNYVESHGTGTVLGDPIEFEALAATYGRGESACALGAVKTNLGHLEA . : . . Mflv_4666|M.gilvum_PYR-GCK AYEQ-----------------------------IMLLRSAVGMAAPQAT- Mvan_1801|M.vanbaalenii_PYR-1 AYEQ-----------------------------VMLLRAAVGMAAPQAT- MSMEG_1941|M.smegmatis_MC2_155 AYEQ-----------------------------IMLLRSAVGMAAPQAT- MMAR_1358|M.marinum_M QYEQ-----------------------------VMLLRAAVGTATPQAT- MUL_2521|M.ulcerans_Agy99 QYEQ-----------------------------VMLLRAAVGTATPQAT- MAV_4148|M.avium_104 QYEQ-----------------------------VMLLRAAVGTAAPEAT- MAB_3516c|M.abscessus_ATCC_199 EYEE-----------------------------VMLLRSAVGMAAPQAT- TH_3022|M.thermoresistible__bu EITVGFPVHTSILEPLRDDLLRNLPQAEFADSPVQFIGAATGDVVPAGTG Mb2402c|M.bovis_AF2122/97 AYLAG----------------------------SITLSDAVAVVAARAN- Rv2381c|M.tuberculosis_H37Rv AYLAG----------------------------SITLSDAVAVVAARAN- MLBr_02356|M.leprae_Br4923 AAGIAG----FIKTVLAVQRGQIPPNLHFSQWNPAIDAASTRFFVPTENS :. .. . Mflv_4666|M.gilvum_PYR-GCK ---------------VPALGAAELVGA-ALEAFAMDADLLSAE---RSRV Mvan_1801|M.vanbaalenii_PYR-1 ---------------VPALGAAELVGA-ALEAFATDADLLAAE---RARV MSMEG_1941|M.smegmatis_MC2_155 ---------------VPALGAAELVGA-ALEALGADDELLDTE---RNRI MMAR_1358|M.marinum_M ---------------APALGAAELVGS-ALEAFASDPELLAAE---RARL MUL_2521|M.ulcerans_Agy99 ---------------APALGVAELVGS-ALEAFASDPELLAAE---RARL MAV_4148|M.avium_104 ---------------TPALGAAELVGA-ALEAFAVDAELLAAE---RGRI MAB_3516c|M.abscessus_ATCC_199 ---------------VPALGAAELVGS-ALETFAVEPGMLAAE---RDRI TH_3022|M.thermoresistible__bu FGPYWYGNLRHLVRFDRAFQTALRCGARTFVELSAHPSLLFAMSELLGDT Mb2402c|M.bovis_AF2122/97 -------------------VVGRLPGRYAVAALGIGE----------QDA Rv2381c|M.tuberculosis_H37Rv -------------------VVGRLPGRYAVAALGIGE----------QDA MLBr_02356|M.leprae_Br4923 SWPISDGQAGPR---RAAVSSFGLGGTNAHVVIEQGPELTPVTECSSNTA * : : Mflv_4666|M.gilvum_PYR-GCK QLLLVDDAQHLD---------------PQAARLVEVLAAG---------- Mvan_1801|M.vanbaalenii_PYR-1 QLLLVDDAQHLD---------------PQAARLVEVLATG---------- MSMEG_1941|M.smegmatis_MC2_155 KLLLVDDAQHLD---------------PQAARLVRALAAG---------- MMAR_1358|M.marinum_M RFLLVDDAQQLD---------------PQAARLVEVLAAG---------- MUL_2521|M.ulcerans_Agy99 RFLLVDDAQQLD---------------PQAARLVEVLAAG---------- MAV_4148|M.avium_104 RVLLVDDAQQLD---------------PQAARLVRVLAAG---------- MAB_3516c|M.abscessus_ATCC_199 ELLLVDDAQHLD---------------PQAALLVRLLAER---------- TH_3022|M.thermoresistible__bu PATLLGSTRRDE---------------PIAETFTANLAAAAVSDPGYDWR Mb2402c|M.bovis_AF2122/97 SALIATTGGWLE---------------LSVVNASSTVAVS---------- Rv2381c|M.tuberculosis_H37Rv SALIATTGGWLE---------------LSVVNASSTVAVS---------- MLBr_02356|M.leprae_Br4923 VSTLVVTGKTASRVAAMAGMLADWVEGPGAEVALADVAHTLNHHRSRHAK : . . :* Mflv_4666|M.gilvum_PYR-GCK ----AELTVIAGDPHQ-------------------------TVFGYRGAD Mvan_1801|M.vanbaalenii_PYR-1 ----AELAVIAGDPHQ-------------------------TVFGYRGAD MSMEG_1941|M.smegmatis_MC2_155 ----TGLTVIAGDPDQ-------------------------SVFGYRGAD MMAR_1358|M.marinum_M ----AEFALIAGDPNQ-------------------------AVFGFRGGE MUL_2521|M.ulcerans_Agy99 ----AEFALIAGDPNQ-------------------------AVFGFRGGE MAV_4148|M.avium_104 ----ADLALIAGDPNQ-------------------------AVFGFRGGD MAB_3516c|M.abscessus_ATCC_199 ----AGFCVIAGDPNQ-------------------------TVFGFRGAD TH_3022|M.thermoresistible__bu AVTPAGPDRLTGFPNAPMRAIPMWAT--------AAPRRIGRAGGVRGEE Mb2402c|M.bovis_AF2122/97 ----GERQAVAAIVDT---------------------------VRSSGHF Rv2381c|M.tuberculosis_H37Rv ----GERQAVAAIVDT---------------------------VRSSGHF MLBr_02356|M.leprae_Br4923 FGTVVARDRIQAVAGLRALAAGKQAPGVVGQQDGTPGSGTVFVYSGRGSQ : . * Mflv_4666|M.gilvum_PYR-GCK PALLRGD----GPALILNRSHRCAAPLADAIAAITRR---------LPGA Mvan_1801|M.vanbaalenii_PYR-1 PALLRGE----GPALTLTRSHRCANPVADAIGAVGRR---------LPGA MSMEG_1941|M.smegmatis_MC2_155 PVLLRDDT---HPAITLTQSYRCAPEIASAITGLGQR---------LPGV MMAR_1358|M.marinum_M PAGLLGGPLDGGPAVTLTMSHRCAPAVARAVSGIARR---------LPGG MUL_2521|M.ulcerans_Agy99 PAGLLGGPLDGGPAVTLTMSHRCAPAVARAVSGIARR---------LPGG MAV_4148|M.avium_104 PGSLLDG---AAPAVTLTTSHRCAPAVARAVSGVAGR---------LPGS MAB_3516c|M.abscessus_ATCC_199 TQLLQVSADSRTTMIELDGSHRCAAPIAELANSVARR---------LPGS TH_3022|M.thermoresistible__bu APGLRIAAEVWEPVAAQPGPASAATPVPVALLELGDTGRLGGWLRELLGN Mb2402c|M.bovis_AF2122/97 ARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQ--------FIGGT Rv2381c|M.tuberculosis_H37Rv ARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQ--------FIGGT MLBr_02356|M.leprae_Br4923 WAGMGRQLLADEPAFTAAVAELEPVFVVHAGFSLHDVLANGKELVGIEQI : . : Mflv_4666|M.gilvum_PYR-GCK DASREFTG-RAEQGTLAVR---IAASPHAESALIADALRRAHLVD----- Mvan_1801|M.vanbaalenii_PYR-1 EATREFTG-SDAPGSVTVQ---IAASPHAESALIADALRRAHLVD----- MSMEG_1941|M.smegmatis_MC2_155 SDTRHWTGNPQREGTVTVR---LAASTHAEGTMIADALRRAHLVD----- MMAR_1358|M.marinum_M SAGRHIDGTGTEDGSVTVR---LAATAHAEAAAIADALRRAHLVD----- MUL_2521|M.ulcerans_Agy99 SAGRHIDGTGTEDGSVTVR---LAATAHAEAAAIADALRRAHLVD----- MAV_4148|M.avium_104 SAGRRIEGAGPGEGSVAVR---LAASAHAEAAAIADALRRAHLVD----- MAB_3516c|M.abscessus_ATCC_199 SPARVIHGVENGPAAVRLA---AVPTETAEASLVVDLLRRSHLID----- TH_3022|M.thermoresistible__bu RPDVVLVGPEAAEVAVVAAPESDTAAPEAGVAAITELVRAGGLRYPAAPG Mb2402c|M.bovis_AF2122/97 TGDVVAPGTTFGDYWYAN-----LRHTVRFDRAVESAIRCG--------- Rv2381c|M.tuberculosis_H37Rv TGDVVAPGTTFGDYWYAN-----LRHTVRFDRAVESAIRCG--------- MLBr_02356|M.leprae_Br4923 QLGLIGMQLTLTELWRSYGVQPDLVIGHSLGEVAAAVVAGALTAAEGLRV : . Mflv_4666|M.gilvum_PYR-GCK -----------GVPWDRMAVIVRSVPRTGASLGRALAAAG--VPVEDPHP Mvan_1801|M.vanbaalenii_PYR-1 -----------GVPWSQMAVIVRSVPRMGAALGRALTAAG--VPLDLPQP MSMEG_1941|M.smegmatis_MC2_155 -----------GIPWSQMAVIVRSVPRVGTALARALTAAG--VPVQDNGT MMAR_1358|M.marinum_M -----------GVPWSQMAVIVRSVPRVAARLPRALAAAG--VPVSIPPI MUL_2521|M.ulcerans_Agy99 -----------GVPWSQMAVIVRSVPRVAARLPRALAAAG--VPVSIPPI MAV_4148|M.avium_104 -----------GVPWSQMAVIVRSVPRAGARLPRALAAAG--VPVTAPAA MAB_3516c|M.abscessus_ATCC_199 -----------GVPWSRMAVIVRSVPRSGAALCRALQSAG--VPVHAESY TH_3022|M.thermoresistible__bu PHCRDVWLVTVGAEQVHPDDPVAPVPAAVAAMHRSLGLENPQIPFHHLDL Mb2402c|M.bovis_AF2122/97 ---------------ARAFIEISAHPALLFAIGQNCEGAAN-LPDGPAVL Rv2381c|M.tuberculosis_H37Rv ---------------ARAFIEISAHPALLFAIGQNCEGAAN-LPDGPAVL MLBr_02356|M.leprae_Br4923 TATRSRLMAPLSGQGGMALLELDAVETEALIVDYSQVTLAIYNSPRQTVI : . : . Mflv_4666|M.gilvum_PYR-GCK DVPLA------NQPAVQALLT--VLEATAEK-LDGERALA---------- Mvan_1801|M.vanbaalenii_PYR-1 EVPLA------EQPAVRALLT--VLEATADG-LDGERALA---------- MSMEG_1941|M.smegmatis_MC2_155 DVPVG------RQPAAAALLT--VLDVTATGHLDADSAVA---------- MMAR_1358|M.marinum_M GGSLA------EEPAVGALLT--VLAATAEG-LNADQALA---------- MUL_2521|M.ulcerans_Agy99 GGSLA------EEPAVGALLT--VLAATAEG-LNADQALA---------- MAV_4148|M.avium_104 SGPLA------EQPAVRALLT--VLLATADG-LDGQRALA---------- MAB_3516c|M.abscessus_ATCC_199 DGPVA------SVPAVHALLL--AVSAAQGG-VTHEDAVT---------- TH_3022|M.thermoresistible__bu EQGVGSDTARDTDPAVAALLMDAVLSATGGGGLAIRTTGAGAVLYRRGLR Mb2402c|M.bovis_AF2122/97 VGSARR-----GERFVDALSANIVSAAVADPGYPWGDLGG---------- Rv2381c|M.tuberculosis_H37Rv VGSARR-----GERFVDALSANIVSAAVADPGYPWGDLGG---------- MLBr_02356|M.leprae_Br4923 AGPTEQIDELIDRVRAQNRFASRVNIEVAPHNPAMDALQPQMRSELADVA . . . Mflv_4666|M.gilvum_PYR-GCK -----------------------LVTGPIGRVDPVSLRQLRR-TLRRG-V Mvan_1801|M.vanbaalenii_PYR-1 -----------------------LVTGPIGRVDPISLRQLRR-ALRRA-A MSMEG_1941|M.smegmatis_MC2_155 -----------------------LLTGPIGRVDPVTLRQLRR-ALRRADG MMAR_1358|M.marinum_M -----------------------LITGPIGRVDPVTLRQLRR-TLRRAVA MUL_2521|M.ulcerans_Agy99 -----------------------LITGPIGRVDPVRLRQLRR-TLRRAVA MAV_4148|M.avium_104 -----------------------LLTGPIGRVDPVSLRQLRR-NLQRANA MAB_3516c|M.abscessus_ATCC_199 -----------------------LATGPLGRVDPVALRRLRR-QLLRAEE TH_3022|M.thermoresistible__bu DVPAPPPLDRPGLLDE------VVITGGAGAIGLHYARQLARRGAKRIVL Mb2402c|M.bovis_AF2122/97 -------------------------DPLDGDVDLSGFPNAPMRAVPMWAH Rv2381c|M.tuberculosis_H37Rv -------------------------DPLDGDVDLSGFPNAPMRAVPMWAH MLBr_02356|M.leprae_Br4923 PRTPTIPILSTTYADLGSCPVFDAQHWATNMRNPVHFQQAIMTAGTDHRT . . . Mflv_4666|M.gilvum_PYR-GCK TAPD-RGFGELLVEALERD---------VAALPDEHARALRRLRAVLTSA Mvan_1801|M.vanbaalenii_PYR-1 PESP-GGFSDLLVDALQRD---------TPALADGQARALRRVCAVLTAA MSMEG_1941|M.smegmatis_MC2_155 SQPP-RDFGDLLVDAIERE---------PKGLSAEHARTLRRLRAVLTAA MMAR_1358|M.marinum_M GRSP-EDFGDLLVATLSEDGRPAVGSAGSNQPPGPQFGPLRRVRAVLAAA MUL_2521|M.ulcerans_Agy99 GRSP-EDFGDLLVATLSEDGRPAVGSAGSNQPPGPQFGPLRRVRAVLAAA MAV_4148|M.avium_104 GRPP-GDFAELLVEALT----------GTAPPPGALFRALRRVRAVLDAA MAB_3516c|M.abscessus_ATCC_199 AAGGERGSAELLRAVLVEADET-----HLAALTDIQAAPLRRVRAVIGAA TH_3022|M.thermoresistible__bu LSRRPVDPAELAALAAPTGAEVLS---VSCDLTDPDAVXXXXVRAVLTAA Mb2402c|M.bovis_AF2122/97 PEPLPPVSGLTIAVERWER----------MVPSTPVAGRHRHLAVLDLGA Rv2381c|M.tuberculosis_H37Rv PEPLPPVSGLTIAVERWER----------MVPSTPVAGRHRHLAVLDLGA MLBr_02356|M.leprae_Br4923 FIEISAHPLLTQAITDTLHGTRCISIGTLQRDADDTVTFHTNLNNVHTVH . : : Mflv_4666|M.gilvum_PYR-GCK RRSAEQGGDPRQTLWQAWNRSGLQKRWLAAAERGGPAAAQAERDLDAVTA Mvan_1801|M.vanbaalenii_PYR-1 RRSAREGSDPRHTLWQAWHRSGLQKRWLAASERGGPAGAQADRDLDAVTA MSMEG_1941|M.smegmatis_MC2_155 RRSDASGADPRYTLWQAWHASGLQRRWLAASERGGSVGAQADRDLDAVTT MMAR_1358|M.marinum_M TRCHRAGQDPRYILWAAWHRSGLQNRWLAAIDRGGPAGVQATRNLEAVTA MUL_2521|M.ulcerans_Agy99 TRCHRAGQDPRYILWAAWHRSGLQNRWLAAIDRGGPAGVQATRNLEAVTA MAV_4148|M.avium_104 GRCHRDGQDPRYILWAAWHRSGLQRRWLSVSERGGPAAAQAGRDLDSVTA MAB_3516c|M.abscessus_ATCC_199 REATASGASVLDVLWAAWTRSGLQRRWDGLSQRGGPLGAQADRDLDAVSS TH_3022|M.thermoresistible__bu ERAHRHGGDPREVLWQAWHRSGLQRRWLAASERGGVAGVQADRDLDAVTA Mb2402c|M.bovis_AF2122/97 HRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGALAD Rv2381c|M.tuberculosis_H37Rv HRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGALAD MLBr_02356|M.leprae_Br4923 PPHTPHPAEPHVTIPSTPWQHTRHWITTPLASTTALQHLDRNRVTTHATG : : * : Mflv_4666|M.gilvum_PYR-GCK LFDVAEQYVERTAGASLR-------------GLIDHITGLSLPPARGD-A Mvan_1801|M.vanbaalenii_PYR-1 MFDVAEQYVARTAGASLR-------------GLVDHITALALPPARRD-E MSMEG_1941|M.smegmatis_MC2_155 LFDVADQYVNRTAGASLR-------------GLVDHVTRLGAAVARTEPE MMAR_1358|M.marinum_M LFDITDQYVSRTSGASLS-------------GLLEHVAALQLPRVSEEPV MUL_2521|M.ulcerans_Agy99 LFDITDQYVSRTSGASLS-------------GLLEHVAALQLPRVSEEPV MAV_4148|M.avium_104 LFDITDDYVSRTSGASLR-------------GLVEHVAALQLPGAGPVPV MAB_3516c|M.abscessus_ATCC_199 LFDLASEHVARTPGIGVT-------------GLIDHIRSLALVGQRTT-R TH_3022|M.thermoresistible__bu FFDAAEQYVARTAGATLR-------------GLIDHLTTLGPAAPARDQS Mb2402c|M.bovis_AF2122/97 LVGAGLLDYPMHIGARCQ-------------SVCLVTVGAEQVDAADAVP Rv2381c|M.tuberculosis_H37Rv LVGAGLLDYPMHIGARCQ-------------SVCLVTVGAEQVDAADAVP MLBr_02356|M.leprae_Br4923 IGNTELDDWIYQLDWPTRPLTSEPGATWASSGSWLVVSDAGLSDELARLV : . . . Mflv_4666|M.gilvum_PYR-GCK RSGDAVALISAHAALSGEWDFVVLAGLQEGL------------------- Mvan_1801|M.vanbaalenii_PYR-1 AAPDAVALLSAHSALGHEWEFVVLAGVQEGL------------------- MSMEG_1941|M.smegmatis_MC2_155 TAAEAVAVLSVHGALAGEWDFVVIAGVQEGL------------------- MMAR_1358|M.marinum_M AQNEQVRVLSAHAALGHEWDLVVIAGLQDGL------------------- MUL_2521|M.ulcerans_Agy99 AQNEQVGVLSAHAALGHEWDLVVIAGLQDGS------------------- MAV_4148|M.avium_104 ATAEQVSVLSAHAALGREWDFVVIAGLQDGL------------------- MAB_3516c|M.abscessus_ATCC_199 LEPDAVAIVSAHAAVGREWDVVAIPGVQEGL------------------- TH_3022|M.thermoresistible__bu ARRDAVAVLSAHAALDREWDLVVIAGLQDGL------------------- Mb2402c|M.bovis_AF2122/97 SAG-QAALAAMHRSIGFEHPEQTFSHLDLPS------------------- Rv2381c|M.tuberculosis_H37Rv SAG-QAALAAMHRSIGFEHPEQTFSHLDLPS------------------- MLBr_02356|M.leprae_Br4923 VLADPASRVEYLAPSALDHDVSTLHDLHNALRGVDNVLYAPSVSTESVDP . . : .: :. Mflv_4666|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1801|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_1941|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_1358|M.marinum_M -------------------------------------------------- MUL_2521|M.ulcerans_Agy99 -------------------------------------------------- MAV_4148|M.avium_104 -------------------------------------------------- MAB_3516c|M.abscessus_ATCC_199 -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 VDPESGYRLFHAVRRLAAAMVAGTSKPKLVVVTRNAQPVAVGERANPAHA Mflv_4666|M.gilvum_PYR-GCK --------------------WPNVSPRGGVLATQHLVDVIDGVAAPGQR- Mvan_1801|M.vanbaalenii_PYR-1 --------------------WPNVSPRGGVLATQQLVDVIDGVCAPGQHT MSMEG_1941|M.smegmatis_MC2_155 --------------------WPNMIPRGGVLGTQHLVDVLDGVADMTDRT MMAR_1358|M.marinum_M --------------------WPNTIPRGGVLATQRLLDELDGVSG----N MUL_2521|M.ulcerans_Agy99 --------------------WPNTIPRGGVLATQRLLDELDGVSG----N MAV_4148|M.avium_104 --------------------WPNTVPRGGVLGTQRLLDVLDGVSA----D MAB_3516c|M.abscessus_ATCC_199 --------------------WPNTAVRGGVLRTQELMDVLAGIEH--AAH TH_3022|M.thermoresistible__bu --------------------WPNTVPRGGVLATQQLVDVLDGVADGSDPV Mb2402c|M.bovis_AF2122/97 --------------------WDLDP----VLGVSVITAVLRGFGETALRG Rv2381c|M.tuberculosis_H37Rv --------------------WDLDP----VLGVSVITAVLRGFGETALRG MLBr_02356|M.leprae_Br4923 VLWGFGRTLALEHPEIWGSVIDLDASMPPELAARCILDEVASQDEKDRED * . : : . Mflv_4666|M.gilvum_PYR-GCK LSSRAPLLAEERRLLIAAMGRARSRVLVTAVDSDS---GDEAALPSPFCH Mvan_1801|M.vanbaalenii_PYR-1 LSSRAPLLAEEWRLLIAAMGRARSRLLVTAVDSDC---GDDAMLPSSFCH MSMEG_1941|M.smegmatis_MC2_155 VSTRAPLVAEERRLLMAAMGRARTRVMITAVDSDT---GDESLLPSPFCA MMAR_1358|M.marinum_M ASARAPLLAEERRLLLAAMGRARRQLLVTAVDGDTSGGGQQAALPSEFFF MUL_2521|M.ulcerans_Agy99 ASARAPLLAEERRLLLAAMGRARRQLLVTAVDGDTSGGGQQAALPSEFFF MAV_4148|M.avium_104 ASVRAPLLAEERRLLVAAMGRARQRLLVTAVDSDTDGSDHEAALPSPFCY MAB_3516c|M.abscessus_ATCC_199 VDGSAVALAEERRLLLLAVGRAARRVLITAVENENADMGGGPAMASRFLT TH_3022|M.thermoresistible__bu VSRRAPLLAEERRLLIAAMGRARSRLLVTAVDSDD---GDESLLPSPFCA Mb2402c|M.bovis_AF2122/97 SVNGYTLFER----TLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYAR Rv2381c|M.tuberculosis_H37Rv SVNGYTLFER----TLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYAR MLBr_02356|M.leprae_Br4923 QVVYRACLRRAPRLQRRTASAVSSVKLSSGQDTTQLVIGATGNIGPHLIR . . . : :. . : Mflv_4666|M.gilvum_PYR-GCK ELAAMAT-EPVPEPALPIRAPRVLSPAAVVGRLRSVVCAGSDEVSEDERV Mvan_1801|M.vanbaalenii_PYR-1 ELAALAT-EPQSQPAPPVRAPRVLAPSALVGRLRSVVCAAPGAVDDVERD MSMEG_1941|M.smegmatis_MC2_155 EISAWAT-EPVAEP--PLVAPRVLAPSALVGRLRAVVCAPDGAVDDDARA MMAR_1358|M.marinum_M EIAQWANGDSQAVAAPPVSAPRVLSAAAVVGRLRGVVCAPDGAVDDAARQ MUL_2521|M.ulcerans_Agy99 EIAQWANGDSQAVAAPPVSAPRVLSAAAVVGRLRGVVCAPDGAVDDAARQ MAV_4148|M.avium_104 EIAQWAGEDVETAALQPVSAPRVLSAAALVGRLRGVVCAPDGAVDELDRR MAB_3516c|M.abscessus_ATCC_199 ELMAAHPEWVISEYRPGAAQSRVLTAANLVGELRAVVTAPVEAVTDARRR TH_3022|M.thermoresistible__bu ELAALAT-EPEAATPAPLPAPRVLTAAALVGRLRSVVCAAPDTVDDEVRA Mb2402c|M.bovis_AF2122/97 YLAEHGARRIVLLSRRAADQATVAMLRKQHG--TVIVSPPCDITDPTQLS Rv2381c|M.tuberculosis_H37Rv YLAEHGARRIVLLSRRAADQATVAMLRKQHG--TVIVSPPCDITDPTQLS MLBr_02356|M.leprae_Br4923 QLAAMGATTIVAVSRNPSTR-LLELDKNLAATGTNLISVAADATDPTAMT : : . :: . Mflv_4666|M.gilvum_PYR-GCK CAAAQLAR--LATAGVHGADPSSWYGARELSSDEPLWDGDDHVVTLSPST Mvan_1801|M.vanbaalenii_PYR-1 CAAAQLAR--LAEAGVHGADPASWYGSRELSSAEPLWEDGEQVVTLSPST MSMEG_1941|M.smegmatis_MC2_155 CAAAQLAR--LAAAGVPGADPSQWHAMTSLTTEEPLWSEPGHVVTLSPST MMAR_1358|M.marinum_M CAATQLAR--LAKAGVAGADPAGWHGLIPVSTTAALY-GAGDVVTLTPST MUL_2521|M.ulcerans_Agy99 CAATQLAR--LAKAGVAGADPAGWHGLIPVSTTAALY-GAGDVVTLTPST MAV_4148|M.avium_104 CAATQLAR--LAQAGVPGADPASWHGLIPVSTAEPLR-GGGDVVTLTPST MAB_3516c|M.abscessus_ATCC_199 AAARQLAR--LAAAGVPGADPESWYGLGDVSDERPLWLAEDGPVRVSPSN TH_3022|M.thermoresistible__bu GAATQLAR--LAAAGVPGADPAQWYAMTPLSTGEPLWDGPGQSVTLSPST Mb2402c|M.bovis_AF2122/97 AIAAEYGG--VGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLG---L Rv2381c|M.tuberculosis_H37Rv AIAAEYGG--VGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLG---L MLBr_02356|M.leprae_Br4923 ALFDRFGVDLPPLEGIYLAAFAGRPVLLSDMTDNDVVAMFRPKLDVASLL . . : * : : Mflv_4666|M.gilvum_PYR-GCK LQMLADCPLRWLLERHGGARGRDVRSTLGSLVHALVSESGTAESVLLDEL Mvan_1801|M.vanbaalenii_PYR-1 LQMLSDCPLRWLLERHGGSRGRDVRSTLGSLVHALVSESGRTESQLLNGL MSMEG_1941|M.smegmatis_MC2_155 LQMLTDCPLRWLLERHGGDDGRDVRSTVGSLVHALVSEPGKTESQLVNEL MMAR_1358|M.marinum_M LQTLNDCPLRWLAERHGGTNPRDLRATIGSVLHALIAEPGASEEQLLAEL MUL_2521|M.ulcerans_Agy99 LQTLNDCPLRWLAERHGGTNPRDLRATIGSVLHALIAEPGASEEQLLAEL MAV_4148|M.avium_104 MQTLTDCPLRWLAERHGGTDPRDLRSAIGSVVHALIAQPHRSPAELVAEL MAB_3516c|M.abscessus_ATCC_199 VETLMACPLRWMLERHGGTDLTDPRRALGTLVHELVGVHAEDSDAMCRAL TH_3022|M.thermoresistible__bu LQTLVDCPLRWLLERHGGTDGRDVRSTVGSLVHALAAGRYRTEGQLLAEL Mb2402c|M.bovis_AF2122/97 AQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQ Rv2381c|M.tuberculosis_H37Rv AQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQ MLBr_02356|M.leprae_Br4923 HRLSLKQPVKYFLLFSSISGLIGSRWLAHYTATSAFLDILGYARRLVGLP . *:: . Mflv_4666|M.gilvum_PYR-GCK DKVWGKLPFDAQWHSDNERIRHLEMLATFLKWRSDTRGELTEVGTEIDVD Mvan_1801|M.vanbaalenii_PYR-1 EKVWEELPFDAQWYSDNERVRHLEMLSTFLRWREGTRGELTEVGTEIEVD MSMEG_1941|M.smegmatis_MC2_155 EKVWDDLPYDAKWYSDNELARHRAMLETFTRWREDTRRQLTEVATEIPVE MMAR_1358|M.marinum_M ARVWKLLPFEADWFSSNELARHRAMIQAFVEWRGQTRSELTEVGVEIDID MUL_2521|M.ulcerans_Agy99 ARVWKLLPFEADWFSSNELARHRAMIQAFVEWRGQTRSELTEVGVEIDID MAV_4148|M.avium_104 DRAWRHLPFAAQWHSDNELARHRAMLEAFAQWRANTRGALTEVGVEVEID MAB_3516c|M.abscessus_ATCC_199 DKAWESMPFESQWYARNELRRHHELLEAFTTWRASTRGELTEVGREIGVD TH_3022|M.thermoresistible__bu ERVWDQLPFESRWYADNELSRHRAMLQTFMRWRERTRRELTEVAAEIAVD Mb2402c|M.bovis_AF2122/97 GRHCVAVKWG-LWQAPKAGEPARGIADAVTIARVE-RSGLRQMAPQQAIE Rv2381c|M.tuberculosis_H37Rv GRHCVAVKWG-LWQAPKAGEPARGIADAVTIARVE-RSGLRQMAPQQAIE MLBr_02356|M.leprae_Br4923 ATVVAWGLWKSLADAQQDATQVSAESGLQPMTDDVAIGALPLVMSPDAPV : : : * : Mflv_4666|M.gilvum_PYR-GCK GVVAGGEGDGPGVRVRG-----RLDRLERDSEGRLVVVDVKTGKSPVSKD Mvan_1801|M.vanbaalenii_PYR-1 GQIAAPDGELPAVRLRG-----RLDRLERDSEGRLVVIDLKTGKSPVSKD MSMEG_1941|M.smegmatis_MC2_155 GIVVEPGENTPGVRVRG-----RLDRLERDEAGRLVVVDLKTGKSPVTKD MMAR_1358|M.marinum_M GVLDAARDDGGAIRLRG-----RVDRLERDGAGRLVIVDIKTAKTPVSKD MUL_2521|M.ulcerans_Agy99 GVLDAARDDGGAIRLRG-----RVDRLERDGAGRLVILDIKTAKTPVSKD MAV_4148|M.avium_104 GTLSTG--DGREVRLRG-----RVDRLERDAAGRLVIVDVKTGKTPVSKD MAB_3516c|M.abscessus_ATCC_199 GVLSRAG--QPQVRLVG-----RIDRLERDAEGRPVVIDIKTGKSPATKD TH_3022|M.thermoresistible__bu GVLVDGADTTPEIRVRG-----RLDRLERDADGRLVVVDLKTGKSPVTKN Mb2402c|M.bovis_AF2122/97 ASLHEFTVDPLVFAADA-----ARLQMLLDSR--------QFERYEGPTD Rv2381c|M.tuberculosis_H37Rv ASLHEFTVDPLVFAADA-----ARLQMLLDSR--------QFERYEGPTD MLBr_02356|M.leprae_Br4923 HSVVAAADWPLLAAAYQTRGVLRMVDDLLPAPGEVLMQESEFRKALRTCQ : : : . : Mflv_4666|M.gilvum_PYR-GCK DAQAHAQLAMYQLAVAAGLIADG---DEPGGGRLVYLGKT-TGGRATERH Mvan_1801|M.vanbaalenii_PYR-1 DAQSHAQLAMYQLAVAAGLLADG---DEPGGGRLVYLGKT-TGGGATERH MSMEG_1941|M.smegmatis_MC2_155 DAQNHAQLAMYQLAVAAGLLDDG---DEPGGGKLVYLGKA-GAAGATERE MMAR_1358|M.marinum_M DAQQNAQLAMYQLAVAEGMVEAG---AEPGGARLVYPGKS-AAAGAAQRD MUL_2521|M.ulcerans_Agy99 DAQQNAQLAMYQLAVAEGMVEAG---AEPGGARLVYPGKS-AAAGAAQRD MAV_4148|M.avium_104 DAQQHAQLALYQLAVAHGLLGAAGGDAEPGGARLVYVGKA-AASGVVERE MAB_3516c|M.abscessus_ATCC_199 DAQQHAQLAAYQVAAAEGLIEGEP-AGAPGGGRLVYIAKPNLDDGATQRH TH_3022|M.thermoresistible__bu DAQRHAQLAMYQLAVAAGLLPAG---DIPGGGRLVYLGRP-TGGGATERE Mb2402c|M.bovis_AF2122/97 PNLTIVDAVRTQLAAVLGIPQAG---EVNLQESLFDLGVDSMLALDLRNR Rv2381c|M.tuberculosis_H37Rv PNLTIVDAVRTQLAAVLGIPQAG---EVNLQESLFDLGVDSMLALDLRNR MLBr_02356|M.leprae_Br4923 AERRHNMLFDHVSALVAKAMGLLPAETLDPSAGFFQLGMDSLMSVTLQRA * . :. . .. Mflv_4666|M.gilvum_PYR-GCK QDAVTPEVREL-----------WEARVHEAAAATQGPSFVARVNDGCAHC Mvan_1801|M.vanbaalenii_PYR-1 QDALTPDGRAE-----------WDEQVHRAAAATQGPQFTARVNDGCAHC MSMEG_1941|M.smegmatis_MC2_155 QDPLTPDKRAE-----------WLETVGEAAAATAGPRFVARVNNGCANC MMAR_1358|M.marinum_M QDPLTPAARDQ-----------WRNLVRQAAEAAAGPHFIARRNDGCSHC MUL_2521|M.ulcerans_Agy99 QDPLTPAARDQ-----------WRNLVRQAAEAAAGPHFIARRNDGCSHC MAV_4148|M.avium_104 QDPLTAAAADQ-----------WREALRRAADATAGPQFIARRNDGCTHC MAB_3516c|M.abscessus_ATCC_199 QDPLTPAAQDA-----------WRESIHNAAASTQGPIFVARVNDGCGHC TH_3022|M.thermoresistible__bu QDPLTPETAAG-----------WRDTVAQAADATRGPRFAARINDGCAHC Mb2402c|M.bovis_AF2122/97 LKRSIGAT----------------VSLATLMGDITGDGLVAKLEDADERS Rv2381c|M.tuberculosis_H37Rv LKRSIGAT----------------VSLATLMGDITGDGLVAKLEDADERS MLBr_02356|M.leprae_Br4923 LSDSLGEFLPASVVFDYPTVYSLTDYLATILPEFLEPEAPSGRTTADAYD . : : . Mflv_4666|M.gilvum_PYR-GCK PVRATCPAQNSRSQP---- Mvan_1801|M.vanbaalenii_PYR-1 PVRAMCPAQN-RSDT---- MSMEG_1941|M.smegmatis_MC2_155 PVRSSCPAQANGDRP---- MMAR_1358|M.marinum_M PIRPSCPAHTDRSPR---- MUL_2521|M.ulcerans_Agy99 PIRPSCPAHTDRSPR---- MAV_4148|M.avium_104 PLRPCCPAHADGSGR---- MAB_3516c|M.abscessus_ATCC_199 PLRTCCPAQTDGQAVCQS- TH_3022|M.thermoresistible__bu PVRFSCPAQAAQAGSERP- Mb2402c|M.bovis_AF2122/97 HTAQKVDISRD-------- Rv2381c|M.tuberculosis_H37Rv HTAQKVDISRD-------- MLBr_02356|M.leprae_Br4923 EFTESELLDQLSERLRGTQ