For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_4178 | - | - | 100% (1868) | mycolic acid condensase |
| M. thermoresistible (build 8) | TH_4458 | - | e-132 | 44.85% (573) | PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide |
| M. thermoresistible (build 8) | TH_2454 | - | e-103 | 43.36% (482) | PUTATIVE beta-ketoacyl synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3830c | pks13 | 0.0 | 70.75% (1846) | polyketide synthase PKS13 |
| M. gilvum PYR-GCK | Mflv_1169 | - | 0.0 | 75.82% (1836) | beta-ketoacyl synthase |
| M. tuberculosis H37Rv | Rv3800c | pks13 | 0.0 | 70.80% (1846) | polyketide synthase PKS13 |
| M. leprae Br4923 | MLBr_00101 | pks13 | 0.0 | 69.38% (1878) | polyketide synthase |
| M. abscessus ATCC 19977 | MAB_0180 | - | 0.0 | 66.81% (1886) | polyketide synthase PKS13 |
| M. marinum M | MMAR_5364 | pks13 | 0.0 | 72.50% (1847) | polyketide synthase Pks13 |
| M. avium 104 | MAV_0218 | - | 0.0 | 71.44% (1877) | polyketide synthase |
| M. smegmatis MC2 155 | MSMEG_6392 | - | 0.0 | 78.22% (1855) | polyketide synthase |
| M. ulcerans Agy99 | MUL_4983 | pks13 | 0.0 | 72.49% (1843) | polyketide synthase Pks13 |
| M. vanbaalenii PYR-1 | Mvan_5640 | - | 0.0 | 75.03% (1866) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1169|M.gilvum_PYR-GCK ------------------------------MAQAQDDSAKSGPD------
Mvan_5640|M.vanbaalenii_PYR-1 ------------------------------MAEAQDGSSKAGPD------
MSMEG_6392|M.smegmatis_MC2_155 --------------------------------------------------
TH_4178|M.thermoresistible__bu MTENPNDSQPPVTGDEAGPQNPAEEVRLADVLPADGPLQPAQTD------
MMAR_5364|M.marinum_M -------------------------MADTDQPQSNEDAQANKSD------
MUL_4983|M.ulcerans_Agy99 -------------------------MADTDQPQSNEDAQANKSD------
Mb3830c|M.bovis_AF2122/97 -------------------------MADVAESQ--ENAPAERAE------
Rv3800c|M.tuberculosis_H37Rv -------------------------MADVAESQ--ENAPAERAE------
MLBr_00101|M.leprae_Br4923 -------------------------MADVDAPQLNQDPPQLNQDPQANLP
MAV_0218|M.avium_104 -------------------------MADIDEPQ--ENTPAKKSDMRAG--
MAB_0180|M.abscessus_ATCC_1997 ---------------MTDTQQDSTPETSLETPAPEVAAPTGGAG------
Mflv_1169|M.gilvum_PYR-GCK -------------------------ITVAEMREWLRNWVGNATGQSPDSI
Mvan_5640|M.vanbaalenii_PYR-1 -------------------------MTVAEMREWLRNWVGNATGQAPDSI
MSMEG_6392|M.smegmatis_MC2_155 -------------------------MTVNEMREWLRNWVANATGQSADAI
TH_4178|M.thermoresistible__bu -------------------------MTVAEMKDWLRNWISNATGQPADRI
MMAR_5364|M.marinum_M -------------------------MTVPEMRQWLRNWVGKAVGKSPDSI
MUL_4983|M.ulcerans_Agy99 -------------------------MTVPEMRQWLRNWVGKAVGKSPDSI
Mb3830c|M.bovis_AF2122/97 -------------------------LTVPEMRQWLRNWVGKAVGKAPDSI
Rv3800c|M.tuberculosis_H37Rv -------------------------LTVPEMRQWLRNWVGKAVGKAPDSI
MLBr_00101|M.leprae_Br4923 AEKTKMRFGDDAERSDEEVRRITRITTVPEMRQWLRNWVGKVVGKSPDDI
MAV_0218|M.avium_104 ------------DDAERSDAEERRPTTVPEMREWLRNWVGRAVGKSPDEI
MAB_0180|M.abscessus_ATCC_1997 -------------------------LTVPEMREWLRNWIAKATGVSPDRI
** **::*****:....* ..* *
Mflv_1169|M.gilvum_PYR-GCK SETAPLVELGLSSRDAVAMASDIEDLTGVTLTATVAFRHPTIEALATVIV
Mvan_5640|M.vanbaalenii_PYR-1 NESAPLVELGLSSRDAVAMASDIEDLTGVTLTATVAFRHPTIESLATVII
MSMEG_6392|M.smegmatis_MC2_155 DESTPMVELGLSSRDAVAMASDIEDLTGVTLTATVAFRHPTIESLATVII
TH_4178|M.thermoresistible__bu DDSTPMVELGLSSRDAVAMASDIEDLTGVTLTATVAFRHPTIESLATVII
MMAR_5364|M.marinum_M DESVPMVELGLSSRDAVAMAADIEDMTGVTLSVAVAFQHPTIESLATRII
MUL_4983|M.ulcerans_Agy99 DESVPMVGLGLSSRDAVAMAADIEDMTGVTLSVAVAFQHPTIESLATRII
Mb3830c|M.bovis_AF2122/97 DESVPMVELGLSSRDAVAMAADIEDLTGVTLSVAVAFAHPTIESLATRII
Rv3800c|M.tuberculosis_H37Rv DESVPMVELGLSSRDAVAMAADIEDLTGVTLSVAVAFAHPTIESLATRII
MLBr_00101|M.leprae_Br4923 DESAPMVELGLASRDAVAMAADIEDLTGVTLSVAVAFQYPTIESLANRII
MAV_0218|M.avium_104 DESVPMVELGLSSRDAVAMAADIEDMTGVTLSVAVAFQHPTIESLATRII
MAB_0180|M.abscessus_ATCC_1997 DDSAPMVEMGLSSRDAVAMAADIEDLTGVTLTATVAFQHPTIESLATRII
.::.*:* :**:********:****:*****:.:*** :****:**. *:
Mflv_1169|M.gilvum_PYR-GCK EGEPEEDR-TADGADWSRDVDEGRANIAIVGVGTRFPGDMNTPDEMWQAL
Mvan_5640|M.vanbaalenii_PYR-1 EGEPEADISALDDEDWSREVDEGVANIAIVGVGTRFPGDMNTPDEMWQAL
MSMEG_6392|M.smegmatis_MC2_155 EGEPEPEP-YDEDEDWSRTRD--VEDIAIVGVATRFPGDLNTPDEMWEAL
TH_4178|M.thermoresistible__bu EGEQETGA-DDDDADWS-RPDADERAIAIVGLSTRFPGEMNTPAETWQAL
MMAR_5364|M.marinum_M EGEPEVADDGIDNIDWTRNGPAERVDIAIVGLATRLPGEMNSPEETWRAL
MUL_4983|M.ulcerans_Agy99 EGEPEVADDGIDNIDWTRNGPAERVDIAIVGLATRLPGEMNSPEETWRAL
Mb3830c|M.bovis_AF2122/97 EGEPETDLAGDDAEDWSRTGPAERVDIAIVGLSTRFPGEMNTPEQTWQAL
Rv3800c|M.tuberculosis_H37Rv EGEPETDLAGDDAEDWSRTGPAERVDIAIVGLSTRFPGEMNTPEQTWQAL
MLBr_00101|M.leprae_Br4923 EGESETIDDDTDAFDWSRTGSAERIDIAVVGLSTRLPGDMNSPEETWRAL
MAV_0218|M.avium_104 EGEPEAVDAG-DDMDWSRSGPAERVDIAIVGLSTRLPGDMNSPDETWQAL
MAB_0180|M.abscessus_ATCC_1997 EGEPEVPDAGDEDWSRDPKIAAGEFDIAVVGLSARLPGDVNSPAQLWEAL
*** * : . **:**:.:*:**::*:* : *.**
Mflv_1169|M.gilvum_PYR-GCK LEGRDAITDLPEGRWSEFLSEPRIAERVAKARTRGGYLSDIKGFDAEFFA
Mvan_5640|M.vanbaalenii_PYR-1 LEARDAITDLPEGRWSEFLSEPRIAERVAKARTRGGYLSDIKGFDAEFFA
MSMEG_6392|M.smegmatis_MC2_155 LEGKDCVTDLPEDRWTEFLDEPRIAERVKKARTRGGYLTDIKGFDSEFFA
TH_4178|M.thermoresistible__bu LEGRDAITDLPEGRWSEFLSEPRIAERVAKAATRGGYLSDIKGFDAEFFA
MMAR_5364|M.marinum_M LEGRDAITDLPEGRWSEFLEEPRIAERVANARTRGGYLSDIKGFDSEFFA
MUL_4983|M.ulcerans_Agy99 LEGRDAITDLPEGRWSEFLEEPRIAERVANARTRGGYLSDIKGFDSEFFA
Mb3830c|M.bovis_AF2122/97 LEGRDGITDLPDGRWSEFLEEPRLAARVAGARTRGGYLKDIKGFDSEFFA
Rv3800c|M.tuberculosis_H37Rv LEGRDGITDLPDGRWSEFLEEPRLAARVAGARTRGGYLKDIKGFDSEFFA
MLBr_00101|M.leprae_Br4923 LEGRDAITDLPAGRWSEFLGEPRLAQRIAQARTRGGYLKDIKGFDSDFFA
MAV_0218|M.avium_104 MEGRDAITDLPEGRWSEFLEEPRIAARVAGARTRGGYLKDIKGFDSEFFA
MAB_0180|M.abscessus_ATCC_1997 LEGRDAITDLPEGRWEEFTAEPRIAERVAQAATRGGYLKDIKGFDAEFFT
:*.:* :**** .** ** ***:* *: * ******.******::**:
Mflv_1169|M.gilvum_PYR-GCK LSKMEADNIDPQQRMALELTWEALEHARIPASSLRGESVGVYLGSSVNDY
Mvan_5640|M.vanbaalenii_PYR-1 LSKMEADNIDPQQRMALELTWEALEDARIPASSLRGENVGVYVGSSTNDY
MSMEG_6392|M.smegmatis_MC2_155 LSKMEADNIDPQQRMALELTWEALEHARIPASSLRGESVGVYIGSSTNDY
TH_4178|M.thermoresistible__bu LSKMEADNLDPQQRMALELTWEALEDARIPASELRGENVGVYIGASNNDY
MMAR_5364|M.marinum_M VAKTEADNIDPQQRMALELTWEALEHARIPPSSLRGGPVGVYVGVSNNDY
MUL_4983|M.ulcerans_Agy99 VAKTEADNIDPQQRMALELTWEALEHARIPPSSLRGGPVGVYVGVSNNDY
Mb3830c|M.bovis_AF2122/97 VAKTEADNIDPQQRMALELTWEALEHARIPASSLRGQAVGVYIGSSTNDY
Rv3800c|M.tuberculosis_H37Rv VAKTEADNIDPQQRMALELTWEALEHARIPASSLRGQAVGVYIGSSTNDY
MLBr_00101|M.leprae_Br4923 VAKTEAENIDPQQRMALELTWEALEHARIPASSLRGEAVGVYIGSSTNDY
MAV_0218|M.avium_104 VAKTEADNIDPQQRMALELTWEALEHARIPASSLRGEAVGVYVGFSNNDY
MAB_0180|M.abscessus_ATCC_1997 LSKMEADNMDPQQRIALELTWEALENARIPASSLKGESVGVYIGSSNNDY
::* **:*:*****:**********.****.*.*:* ****:* * ***
Mflv_1169|M.gilvum_PYR-GCK MFISVADPAVAHPYAITGNSSAVVANRVSYFYDFRGPSMAIDTACSSSLV
Mvan_5640|M.vanbaalenii_PYR-1 SFLGVADPSTAHPYAITGTASSIIANRVSYFYDFRGPSMAIDTACSSSLV
MSMEG_6392|M.smegmatis_MC2_155 SFLAMSDPSIAHPYAITGTASSIIANRVSYFYDFRGPSVAVDTACSSSLV
TH_4178|M.thermoresistible__bu SFLAVSDPTVAHPYAITGTASSIIANRVSYFFDFRGPSVAVDTACSSSLV
MMAR_5364|M.marinum_M SFLAVSDPTIAHPYAITGTATSIIANRVSYFYDFRGPSVAIDTACSSSLV
MUL_4983|M.ulcerans_Agy99 SFLAVSDPTIAHPYAITGTATSIIANRVSYFYDFRGPSVAIDTACSSSLV
Mb3830c|M.bovis_AF2122/97 SFLAVSDPTVAHPYAITGTSSSIIANRVSYFYDFHGPSVTIDTACSSSLV
Rv3800c|M.tuberculosis_H37Rv SFLAVSDPTVAHPYAITGTSSSIIANRVSYFYDFHGPSVTIDTACSSSLV
MLBr_00101|M.leprae_Br4923 SFLAVSDPTIAHPYAITGTSSSIIANRVSYFYDFRGPSVTIDTACSSSLV
MAV_0218|M.avium_104 QFLAVSDPTVAHPYAITGTASSIIANRVSYFYDFRGPSVAVDTACSSSLV
MAB_0180|M.abscessus_ATCC_1997 SYLSVADPTVTHPYAITGNASSIIANRVSYFYDFRGPSVAVDTACSSSLV
::.::**: :*******.:::::*******:**:***:::*********
Mflv_1169|M.gilvum_PYR-GCK AVHEGIKALRGGDADVVIAGGVNALITPLVTLGFDEVGGVLAPDGRIKSF
Mvan_5640|M.vanbaalenii_PYR-1 AVHEGVKALRSGDADVVLAGGVNALVTPLVTVGFDEVGGVLAPDGRIKSF
MSMEG_6392|M.smegmatis_MC2_155 ATHQGVQALRAGEADVAIVGGVNALVTPLVTVGFDEVGGVLAPDGRIKSF
TH_4178|M.thermoresistible__bu AVHQGVQALRSGEADVVVAGGVNALVTPMVTIGFDEVGGVLAPDGRIKSF
MMAR_5364|M.marinum_M AVHQGVQALRNGEADVVVAGGVNALVTPMVTLGFDEIGAVLAPDGRIKSF
MUL_4983|M.ulcerans_Agy99 AVHQGVQALRNGEADVVVAGGVNALVTPMVTLGFDEIGAVLAPDGRIKSF
Mb3830c|M.bovis_AF2122/97 AIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGAVLAPDGRIKSF
Rv3800c|M.tuberculosis_H37Rv AIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGAVLAPDGRIKSF
MLBr_00101|M.leprae_Br4923 AIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGSVLAPDGRIKSF
MAV_0218|M.avium_104 ATHQAVQALRNGECDVAIAGGVNALLTPLVTLGFDEIGQVLAPDGRIKSF
MAB_0180|M.abscessus_ATCC_1997 AVHQGVKALRSGEADVVVAGGVNALITPVVTVGFDEVGGVLAPDGRIKSF
* *:.::*** *:.**.:.******:**:**:****:* ***********
Mflv_1169|M.gilvum_PYR-GCK SKDADGYARSEGGGVVVLKRLEDARRDGDQILAVIAGGAVNHDGRSNGML
Mvan_5640|M.vanbaalenii_PYR-1 SKDADGYARSEGGGMLVLKRLADARRDGDQIYAVIAGAAINHDGRSNGML
MSMEG_6392|M.smegmatis_MC2_155 SSDADGYARSEGGGMLVLKRISDARRDGDQILAVIAGSAVNHDGRSNGLL
TH_4178|M.thermoresistible__bu SSDANGYSRSEGGGMLVLKRLADARRDGDEIYAIIAGSAVNHDGRSNGML
MMAR_5364|M.marinum_M SADADGYTRSEGAGMLVLKRVDDARRDGDQILAVIAGSAVNHDGRSNGLI
MUL_4983|M.ulcerans_Agy99 SADADGYTRSEGAGMLVLKRVDDARRDGDQILAVIAGSAVNHDGRSNGLI
Mb3830c|M.bovis_AF2122/97 SADADGYTRSEGGGMLVLKRVDDARRDGDAILAVIAGSAVNHDGRSNGLI
Rv3800c|M.tuberculosis_H37Rv SADADGYTRSEGGGMLVLKRVDDARRDGDAILAVIAGSAVNHDGRSNGLI
MLBr_00101|M.leprae_Br4923 SSDADGYTRSEGGGVLVLKRVNDARRDGDQILAVIAGSAVNHDGRSNGLI
MAV_0218|M.avium_104 SADADGYTRSEGGGMFVLKRVDDARRDGDQILAVIAGSAVNHDGRSNGLI
MAB_0180|M.abscessus_ATCC_1997 SQDANGYSRSEGGGMLVLKRLSDARRDGDPIMAIIAGSAVNHDGRSNGLL
* **:**:****.*:.****: ******* * *:***.*:********::
Mflv_1169|M.gilvum_PYR-GCK APNPDAQEAVLRKAYKDAGIDPRDVDYVEAHGTGTILGDPIEADALGRVI
Mvan_5640|M.vanbaalenii_PYR-1 APNPDAQEAVLRKAYKDAGINPRTVDYVEAHGTGTILGDPIEADALGRVI
MSMEG_6392|M.smegmatis_MC2_155 APNPDAQAEVLRKAYKDAGINPRDVDYIEAHGTGTILGDPIEADALGRIV
TH_4178|M.thermoresistible__bu APNPDAQADVLRKAYQDAGINPRDVDYIEAHGTGTILGDPIEADALGRVV
MMAR_5364|M.marinum_M APNQDAQADVLRRAYKDAGIDPRNVDYIEAHGTGTILGDPIEAEALGRVV
MUL_4983|M.ulcerans_Agy99 APNQDAQADVLRRAYKDAGIDPRNVDYIEAHGTGTILGDPIEAEALGRVV
Mb3830c|M.bovis_AF2122/97 APNQDAQADVLRRAYKDAGIDPRTVDYIEAHGTGTILGDPIEAEALGRVV
Rv3800c|M.tuberculosis_H37Rv APNQDAQADVLRRAYKDAGIDPRTVDYIEAHGTGTILGDPIEAEALGRVV
MLBr_00101|M.leprae_Br4923 APNQDAQADVLRRAYKDAGIDPRTVDYIEAHGTGTVLGDPIEAEALGRVV
MAV_0218|M.avium_104 APNQDAQAEVLRRAYKDAGIDPRTVDYIEAHGTGTVLGDPIEAEALGRVV
MAB_0180|M.abscessus_ATCC_1997 APNPDAQAEVLRKAYKDAGIDPRSVDVIEAHGTGTILGDPIEADGLGRVV
*** *** ***:**:****:** ** :*******:*******:.***::
Mflv_1169|M.gilvum_PYR-GCK GRGRAADKPALLGAVKSNIGHLESAAGAASLAKVALALHYNKIPASINYT
Mvan_5640|M.vanbaalenii_PYR-1 GRGRAADRPALLGAVKSNVGHLESAAGAASLAKVALSLQRNKIPPSINYS
MSMEG_6392|M.smegmatis_MC2_155 GKGRPADKPALLGAVKSNLGHLESAAGAASLAKMTLALANDKLPPSINYA
TH_4178|M.thermoresistible__bu GRNRPADRPALLGAVKSNLGHLESAAGAASLAKVSLALKHNKLPPSINFA
MMAR_5364|M.marinum_M GKGRPADRPALLGAVKTNIGHLESAAGAASMAKVVLALQHDKLPPSINFA
MUL_4983|M.ulcerans_Agy99 GKGRPADRPALLGAVKTNIGHLESAAGAASMAKVVLALQHDKLPPSINFA
Mb3830c|M.bovis_AF2122/97 GRGRPADRPALLGAVKTNVGHLESAAGAASMAKVVLALQHDKLPPSINFA
Rv3800c|M.tuberculosis_H37Rv GRGRPADRPALLGAVKTNVGHLESAAGAASMAKVVLALQHDKLPPSINFA
MLBr_00101|M.leprae_Br4923 GRGRPADRPALLGAVKTNVGHLESAAGAASMVKVVLALQHDKLPPSINFA
MAV_0218|M.avium_104 GRGRPADRPALLGAVKTNVGHLESAAGAASLAKVVLALQHDKLPPSINFA
MAB_0180|M.abscessus_ATCC_1997 GRGRDADKPALLGSAKSNFGHLESAAGAASLSKIVLALQNNKVPPSINYT
*:.* **:*****:.*:*.***********: *: *:* :*:*.***::
Mflv_1169|M.gilvum_PYR-GCK GPNPYIDFDREHLKVADTLSDWPRYSGHAVAGVSGFGFGGANAHLVVREV
Mvan_5640|M.vanbaalenii_PYR-1 GPNPYIDFDKEHLKVADTVTDWPRYSGHAIAGVSGFGFGGANAHLVLREV
MSMEG_6392|M.smegmatis_MC2_155 GPNPYIDFEKERLKVNDTVSDWPRYSGKAIAGVSGFGFGGANAHVVMREV
TH_4178|M.thermoresistible__bu GPNPYIDFEGLRLKVADTVTDWPRYSGKAIAGVSGFGFGGANAHLVLREV
MMAR_5364|M.marinum_M GPSPYIDFDAMRLKVVDAATDWPRYGGYALAGVSSFGFGGANAHVVVREV
MUL_4983|M.ulcerans_Agy99 GPSPYIDFDAMRLKVVDAATDWPRYGGYALAGVSSFGFGGANAHVVVREV
Mb3830c|M.bovis_AF2122/97 GPSPYIDFDAMRLKMITTPTDWPRYGGYALGGVSSFGFGGANAHVVVREV
Rv3800c|M.tuberculosis_H37Rv GPSPYIDFDAMRLKMITTPTDWPRYGGYALAGVSSFGFGGANAHVVVREV
MLBr_00101|M.leprae_Br4923 GPSPYIDFDAMRLKVIDTATDWPRYGGYALAGVSSFGFGGANAHLVVREV
MAV_0218|M.avium_104 GPSPYIDFDGMRLKVIDSPTDWPRYGGYALAGVSSFGFGGANAHLVVREV
MAB_0180|M.abscessus_ATCC_1997 GPNPYIDFDAIHLKVVDQVSEWPRYSGHAIAGVSGFGFGGANAHIVVREV
**.*****: :**: ::****.* *:.***.*********:*:***
Mflv_1169|M.gilvum_PYR-GCK LPTDLVEPAPEPDVAVVTPASD---AKPAVYVGGMLVEDD----EDE---
Mvan_5640|M.vanbaalenii_PYR-1 LPTDLVEPAPEPDVAVVTPAND---DAKAVYVGGVRMDEYGEFVSDEPLA
MSMEG_6392|M.smegmatis_MC2_155 LAGDLVEPEPEP-EPEAKPEKS---EADAVYVGGVRMDEYGEFIDED---
TH_4178|M.thermoresistible__bu LPSDLVEPEPAPEPAADKPAKS---DADAVYIGGVRVDADDHDDAADHDA
MMAR_5364|M.marinum_M LPRDVIEREPDPESAPAAPAQAGESEAASAEGHALRFDEYGEIITDAP--
MUL_4983|M.ulcerans_Agy99 LPRDVIEREPDPESAPAAPAQAGESEAASAEGHALRFDEYGEIITDAP--
Mb3830c|M.bovis_AF2122/97 LPRDVVEKEPEPEPEPKAAAEP--AEAPTLAGHALRFDEFGNIITDS---
Rv3800c|M.tuberculosis_H37Rv LPRDVVEKEPEPEPEPKAAAEP--AEAPTLAGHALRFDEFGNIITDS---
MLBr_00101|M.leprae_Br4923 LPRDVIEPERQPESPVPAAATT---ETAMLEGRVLRFDECGEIITDV---
MAV_0218|M.avium_104 LPRDVIEREPEPTPAPQAAAEP--TESPEPQAHALRFDDFGNVIPDP---
MAB_0180|M.abscessus_ATCC_1997 LPIDLVEPSESTEPESDDADTN--GKHAVAEADTADGDEFSVSRFDEYG-
*. *::* . . :
Mflv_1169|M.gilvum_PYR-GCK ------YQDDDRGDDEFYGRVV--DEEPELPGLTDEALRLLEVAREELAA
Mvan_5640|M.vanbaalenii_PYR-1 RRESGFDEDDDRGDDEFYGRLP--EEEPELPGLTDEALRLLEVAREELAA
MSMEG_6392|M.smegmatis_MC2_155 -------EPAEGGD--AYPSYD--EDSYELPGITEAAQRLLEQAREELEA
TH_4178|M.thermoresistible__bu DG-AEYAERRDRMDFYGDDTYVPSDAEPELPGMTEEAQRLLEAARAELES
MMAR_5364|M.marinum_M ------------------SYGQAEEAEPELPGVTEEALRLKEVALEELAA
MUL_4983|M.ulcerans_Agy99 ------------------SYGQAEEAEPELPGVTEEALRLKEVALEELAA
Mb3830c|M.bovis_AF2122/97 --------------------AVAEEPEPELPGVTEEALRLKEAALEELAA
Rv3800c|M.tuberculosis_H37Rv --------------------AVAEEPEPELPGVTEEALRLKEAALEELAA
MLBr_00101|M.leprae_Br4923 --------------------ADFGESEPELPGMTDEALQLKQAALEALAV
MAV_0218|M.avium_104 --------------------EAPEEGEHELPGLTEEALRLKAIALEELAA
MAB_0180|M.abscessus_ATCC_1997 -----------------EFTGGYSDEPYELPGLTDEAKRLKEEGLAALAA
: ****:*: * :* . *
Mflv_1169|M.gilvum_PYR-GCK AEA-ADPPTQLVPLAVSGFLSSRKKATAAELADWVDSPEGRAASLESIGR
Mvan_5640|M.vanbaalenii_PYR-1 AEA-ENPTTPIVPIAVSGFLTSRKRATAAELADWIDSPEGRASSLEAIGR
MSMEG_6392|M.smegmatis_MC2_155 KEA-EEPTKQLVPLAVSAFLTSRKRQAAAELADWIDSPEGRASSLESIGR
TH_4178|M.thermoresistible__bu QEQ-SKP---LVPLAVSAFLTSRKKAAAAELADWIDSPAGRAASLESIGR
MMAR_5364|M.marinum_M KEEAEGPTKPLIPLAVSAFLTSRKKAAAAELADWMESPEGQASSLESIGR
MUL_4983|M.ulcerans_Agy99 KEEPEGPTKPLIPLAVSAFLTSRKKAAAAELADWMESPEGQASSLESIGR
Mb3830c|M.bovis_AF2122/97 QEV----TAPLVPLAVSAFLTSRKKAAAAELADWMQSPEGQASSLESIGR
Rv3800c|M.tuberculosis_H37Rv QEV----TAPLVPLAVSAFLTSRKKAAAAELADWMQSPEGQASSLESIGR
MLBr_00101|M.leprae_Br4923 KQV----TAPLIPLVVSSFLTSRKKAAAAELADWMDSPQGRASSLESIGR
MAV_0218|M.avium_104 QQESE-PTKPLIPLAVSAFLTSRKKAAAAELADWMESPEGQASSLESIGR
MAB_0180|M.abscessus_ATCC_1997 EEP----VAPVVPLFISGFLSSRKKAAAAALADWMETEEGQSYSLESIGR
: ::*: :*.**:***: :** ****::: *:: ***:***
Mflv_1169|M.gilvum_PYR-GCK SLSRRNHGRSRAVVLAHDHDEAVKGLRAVAEGKTHPSVISSDGPVTNGPV
Mvan_5640|M.vanbaalenii_PYR-1 SLSRRNHGRSRAVVLAHDHDEAVKGLRSIAEGKPNPIVISADGPVTNGPV
MSMEG_6392|M.smegmatis_MC2_155 SLSRRNHGRSRAVVLAHDHDEAIKGLRALAEGKQHPSVLSADGPVTNGPV
TH_4178|M.thermoresistible__bu SLSRRNHARSRAVVLARDHDEAIKGLRALAEGKQHPSLLTADGPVANGPV
MMAR_5364|M.marinum_M SLSRRNHGRSRAVVLAHDHEEAIKGLRAVAEGKQRPGVFSVDGPVTNGPV
MUL_4983|M.ulcerans_Agy99 SLSRRNHGRSRAVVLAHDHEEAIKGLRAVAEGKQRPGVFSVDGPVTNGPV
Mb3830c|M.bovis_AF2122/97 SLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAGKQAPNVFSVDGPVTTGPV
Rv3800c|M.tuberculosis_H37Rv SLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAGKQAPNVFSVDGPVTTGPV
MLBr_00101|M.leprae_Br4923 SLSRRNHGRSRAVVLAHYHDEAIEGFRAIAEGKQRPHVFSVDGPVTNGPV
MAV_0218|M.avium_104 ALSRRNHGRSRAVVLAHDHEEAIKGLRAVAEGKQRPNVFSTDGPVTNGPV
MAB_0180|M.abscessus_ATCC_1997 SLSRRNHGRSRAVVLAHDHEEAIKGLRAVAEGKQKPYVYSADGPVSNGPV
:******.********: *:**::*:*::* ** * : : ****:.***
Mflv_1169|M.gilvum_PYR-GCK WVLAGFGAQHRKMAKSLYLRDEIFADWINKVDSLIQDERGHSILELILDD
Mvan_5640|M.vanbaalenii_PYR-1 WVLAGFGAQHRKMAKSLYLRDQTFAEWINKVDSLIQDERGHSIVELILDD
MSMEG_6392|M.smegmatis_MC2_155 WVLAGFGAQHRKMGKSLYLRNEVFAEWINKVDALIQDERGYSILELILDD
TH_4178|M.thermoresistible__bu WVLAGFGAQHRKMGKSLYLRNEVFAEWINKVDALIQDERGYSILELILDD
MMAR_5364|M.marinum_M WVLAGFGAQHRKMGKSLYLRNPVFAEWIEKVDALVQDELGYSVLELILDD
MUL_4983|M.ulcerans_Agy99 WVLAGFGAQHRKMGKSLYLRNPVFAEWIEKVDALVQDELGYSVLELILDD
Mb3830c|M.bovis_AF2122/97 WVLAGFGAQHRKMGKSLYLRNEVFAAWIEKVDALVQDELGYSVLELILDD
Rv3800c|M.tuberculosis_H37Rv WVLAGFGAQHRKMGKSLYLRNEVFAAWIEKVDALVQDELGYSVLELILDD
MLBr_00101|M.leprae_Br4923 WVFAGFGAQHREMGKSLYLRNQVFAEWIEKVDALVQDERGYSVLELILDD
MAV_0218|M.avium_104 WAMAGFGAQHRKMGKNLYLRNEVFAEWIEKVDALIQDERGYSVLELILDD
MAB_0180|M.abscessus_ATCC_1997 WVMAGFGAQHRKMGKSLYLRDPIFAEWIDKVDSYVQEERGYSVVELILDD
*.:********:*.*.****: ** **:***: :*:* *:*::******
Mflv_1169|M.gilvum_PYR-GCK AIDYSDETTELPIEKVQLVIFGIQIALGELLKAHGARPGALIGQSLGEAA
Mvan_5640|M.vanbaalenii_PYR-1 AIDYTDETTELPIEKVQLVIFAIQVALGELLKAHGAKPGALIGQSLGEAA
MSMEG_6392|M.smegmatis_MC2_155 NVDYTDATCEYPIEVVQLVIFAIQIALGELLRHHGAKPAAVVGQSLGEAA
TH_4178|M.thermoresistible__bu SVDYTDATCEYPIEVVQLVIFAIQIALGELLRHHGAKPAAVIGQSLGEAA
MMAR_5364|M.marinum_M SQDYG-------IETTQVTIFAIQIALGELLKHHGAKPAAVVGQSLGEAA
MUL_4983|M.ulcerans_Agy99 SQDYG-------IETTQVTIFAIQIALGELLKHHGAKPAAVVGQSLGEAA
Mb3830c|M.bovis_AF2122/97 AQDYG-------IETTQVTIFAIQIALGELLRHHGAKPAAVIGQSLGEAA
Rv3800c|M.tuberculosis_H37Rv AQDYG-------IETTQVTIFAIQIALGELLRHHGAKPAAVIGQSLGEAA
MLBr_00101|M.leprae_Br4923 AQDYG-------IETTQVTIFAIQIALGELLKHHGAKPAAVVGQSLGEAA
MAV_0218|M.avium_104 SHEYG-------IETSNVVIFAIQIALGELLRHHGAKPAAVVGQSLGEPA
MAB_0180|M.abscessus_ATCC_1997 SHEYG-------IETSNIAIFAIQIGLGEVLKAHGAKPTAVIGQSLGEPA
:* ** ::.**.**:.***:*: ***:* *::******.*
Mflv_1169|M.gilvum_PYR-GCK AAYFSGGLSLEDATRTICSRAHLMGEGEAMLFGEYIRLMALVEYSADEIE
Mvan_5640|M.vanbaalenii_PYR-1 AAYFSGGLSLEDATRTICSRSHLMGEGEAMLFGEYIRLMALVEYSAEEIV
MSMEG_6392|M.smegmatis_MC2_155 ASYFAGGLSLADATRTICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIK
TH_4178|M.thermoresistible__bu AAYFCGGLSLADATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIK
MMAR_5364|M.marinum_M SAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIK
MUL_4983|M.ulcerans_Agy99 SAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIK
Mb3830c|M.bovis_AF2122/97 SAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIR
Rv3800c|M.tuberculosis_H37Rv SAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIR
MLBr_00101|M.leprae_Br4923 CAYFVGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIK
MAV_0218|M.avium_104 SAYFSGGLSLADATRVICSRSHLMGEGEAMLFGEYIRFMALVEYSADELK
MAB_0180|M.abscessus_ATCC_1997 SAYFAGGLSLADATRVICSRAHLMGEGEAMLFGDYIRLMALVEYSADELK
.:** ***** ****.****:************:***:********:*:
Mflv_1169|M.gilvum_PYR-GCK TVFSD---YKNLEVCVYAAPNQTVIGGPPDQVDAIIERAESEGKFARKFQ
Mvan_5640|M.vanbaalenii_PYR-1 SVFGEDEAFNNLEVCVYAAPTQSVIGGPPDQVDAIIARAESEGKFARKFQ
MSMEG_6392|M.smegmatis_MC2_155 TVFSD---YPDLEVCVYAAPTQTVIGGPPDQVDAIIARAESEGKFARKFQ
TH_4178|M.thermoresistible__bu TVFAD---YPDLEVCVYAAPTQTVIGGPPDQVDAIIARAEQEGKFARKFQ
MMAR_5364|M.marinum_M TVFSD---FPDLEVCVYAAPTQTVIGGPPEQVDAIIARAESEGKFARKFQ
MUL_4983|M.ulcerans_Agy99 TVFSD---FPDLEVCVYAAPTQTVIGGPPEQVDAIIARAESEGKFARKFQ
Mb3830c|M.bovis_AF2122/97 EVFSD---FPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAEGKFARKFA
Rv3800c|M.tuberculosis_H37Rv EVFSD---FPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAEGKFARKFA
MLBr_00101|M.leprae_Br4923 TVFSD---FPDLEVCVYAAPTQIVIGGPPEQVDAIIARAKAEGKFARKFA
MAV_0218|M.avium_104 TVFAD---FPGLEVCVYAAPSQTVIGGPPEQIDAIVARAEAEGRFARKLQ
MAB_0180|M.abscessus_ATCC_1997 TVFAD---FPDLEVCVYAAPSQTVIGGPPAQVDAIVARCEAEGKFARKLQ
**.: : .*********.* ****** *:***: *.: **:****:
Mflv_1169|M.gilvum_PYR-GCK TKGASHTTQMDPLLGELAAELQGIEAHPVQVPYYSTVHEGSLVRAGSDAI
Mvan_5640|M.vanbaalenii_PYR-1 TKGASHTSQMDPLLGELAAELQGIEAHPVQVPYYSTVHEGSLIRAGSDPI
MSMEG_6392|M.smegmatis_MC2_155 TKGASHTQQMDPLLGELAAELQGIEPKPLTTGYFSTVHEGTFIRPGSAPI
TH_4178|M.thermoresistible__bu TKGASHTQQMDPLLGELAAELQGIQPLPTTVGLYSTVHEGTFVRPGS-VV
MMAR_5364|M.marinum_M TKGASHTQQMDPLLGELAAELQGIKPMSPTAGIFSTVHEGSYVKPGSDPI
MUL_4983|M.ulcerans_Agy99 TKGASHTQQMDPLLGELAAGLQGIKPMSPTAGIFSTVHEGSYVKPGSDPI
Mb3830c|M.bovis_AF2122/97 TKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRYIKPGGEPI
Rv3800c|M.tuberculosis_H37Rv TKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRYIKPGGEPI
MLBr_00101|M.leprae_Br4923 TKGASHTQQMDPLLGELAAELQGIKPMSPTAGIYSTVHEGSYIKPGSDPI
MAV_0218|M.avium_104 TKGAGHTSQMDPLLGEFSAELQGIKPMSPTVGIFSTVHEGTYIKPGSEPV
MAB_0180|M.abscessus_ATCC_1997 TKGAGHTSQMDPLLGEFAAELQGIEPMSPKIGIFSTVHEGTFIRGGGEPV
****.** ********::* ****:. . :****** :: *. :
Mflv_1169|M.gilvum_PYR-GCK HDVEYWKKGLRHSVYFTHGIRNAVDNGHTTFLELAPNPVALMQVGLTTAA
Mvan_5640|M.vanbaalenii_PYR-1 HDVDYWKKGLRHSVYFTHGIRNAVDNGHTTFLELAPNPVALMQVGLTTAA
MSMEG_6392|M.smegmatis_MC2_155 HDVDYWKKGLRHSVYFTQGIRNAVDNGHTTFLELAPNPVALMQVGLTTAS
TH_4178|M.thermoresistible__bu HDVDYWKKGLRHSVYFTQGVRNAVDNGHTTFLELAPNPVALMQVGLTTAA
MMAR_5364|M.marinum_M HDVDYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVGLTTAS
MUL_4983|M.ulcerans_Agy99 HDVDYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVGLTTAS
Mb3830c|M.bovis_AF2122/97 HDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVALTTAD
Rv3800c|M.tuberculosis_H37Rv HDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVALTTAD
MLBr_00101|M.leprae_Br4923 HDVDYWKKGLRHSVHFTQGIRNAVDNGHTTFLELAPNAVALMQVGLTTAA
MAV_0218|M.avium_104 HDVAYWVKGMRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQIGLTTAA
MAB_0180|M.abscessus_ATCC_1997 HDVDYWKKGMRHSVYFTHGTRNAVDAGHTTFLELAPNPVALMQVGLTTMA
*** ** **:****:**:* ***** ***********.*****:.***
Mflv_1169|M.gilvum_PYR-GCK AGLHDAQLIPTLARKQDEVDSMTSAMAHLFVHGHDLDFRTLFTKAED---
Mvan_5640|M.vanbaalenii_PYR-1 AGLHDAQLIPTLARKQDEVDSMTTAMAHLYVYGHDLDMRTLFPLPADRPV
MSMEG_6392|M.smegmatis_MC2_155 AGLHDAQLIATLARKQDEVESMISAMAQLYVHGHDLDFRTLFPRRSKG-L
TH_4178|M.thermoresistible__bu AGLHDAQLIATLARKQDEVDSMTTAMAHLFVHGHDLDIRTLFG-------
MMAR_5364|M.marinum_M AGLHDAQLIPTLARKQDEVESMISTLAQLYVHGHDLDMRTLFPGPAGP--
MUL_4983|M.ulcerans_Agy99 AGLHDAQLIPTLARKQDEVESMISTLAQLYVHGHDLDMRTLFQGPAGP--
Mb3830c|M.bovis_AF2122/97 AGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTLFSRASGP--
Rv3800c|M.tuberculosis_H37Rv AGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTLFSRASGP--
MLBr_00101|M.leprae_Br4923 VGLHDAQLIPTLSRNQDEVESMISTMAQLYVYGHDLDIWTLFSRAVGP--
MAV_0218|M.avium_104 AGLHDAQLIPTLAKKQDDVESMISAMAQLYVYGHDLDIRTLFTRAKGP--
MAB_0180|M.abscessus_ATCC_1997 SGLPDAQLIATLARKEDEVESMVKAMAQLYVHGHALDPRTLFSRAAKS--
** *****.**::::*:*.** .::*:*:*:** ** ***
Mflv_1169|M.gilvum_PYR-GCK -PETDFAAIPPTRFKRKPHWLDVNFTGDSSSVMPGNHVATPDGRHVWEYS
Mvan_5640|M.vanbaalenii_PYR-1 DPATDYADIPPTRFKRKPHWLEAHFTGDSSAVMPGNHVATPDGRHVWEYL
MSMEG_6392|M.smegmatis_MC2_155 AGALDFANIPPTRFKRKEHWLPAHFTGDSSAVMPGNHVATPDGRHVWEFV
TH_4178|M.thermoresistible__bu --KGEFADIPPTRFRRKEHWLDAKFTGDSSVLMPGNHVATPDGRHVWEYA
MMAR_5364|M.marinum_M ---ADYAIIPPTRFKRKEHWLDAKFSGDASVIMPGNHVALPDGRHVWEFA
MUL_4983|M.ulcerans_Agy99 ---ADYAIIPPTRFKRKEHWLDAKFSGDASVIMPGNHVALPDGRHVWEFA
Mb3830c|M.bovis_AF2122/97 ---QDYANIPPTRFKRKEHWLPAHFSGDGSTYMPGTHVALPDGRHVWEYA
Rv3800c|M.tuberculosis_H37Rv ---QDYANIPPTRFKRKEHWLPAHFSGDGSTYMPGTHVALPDGRHVWEYA
MLBr_00101|M.leprae_Br4923 ---EDYADIPPTRFKRKEHWLDVHFAGDGSVSMPGNHVALPDSRHVWEFA
MAV_0218|M.avium_104 ---QDYANIPPTRFKRKEHWLDVHFSGDGSVIMPGTHVALPDGRHVWEYA
MAB_0180|M.abscessus_ATCC_1997 ---SDYAPIPATEFKRKPHWLPAHFSADGSTRIPGTHVSLPDGKHVWEWS
::* **.*.*:** *** .:*:.*.* :**.**: **.:****:
Mflv_1169|M.gilvum_PYR-GCK ARGAVDGQALAALVKAAAVAVIPDSTLTASEQRAVPADGSRLVTTLTRHP
Mvan_5640|M.vanbaalenii_PYR-1 PKGETD---LAALVKAAAAVVLPDAKLTASEQRAVPGEGSRLVTTLTRHP
MSMEG_6392|M.smegmatis_MC2_155 PRGKTD---LAALVKAAAAQVLPDAKLAAFEQRAVPADNARLVTTLTRHP
TH_4178|M.thermoresistible__bu PKGETD---LAALVKSAAAQVLPDAKLVAYEQRAVPAEGARLVTTLTRHP
MMAR_5364|M.marinum_M P--REA-TDLAALVRAAATQVLPDARLSAAEQRALPGEGARLVTTLARHP
MUL_4983|M.ulcerans_Agy99 P--REA-TDLAALVRAAATQVLPDARLSAAEQRALPGEGARLVTTLARHP
Mb3830c|M.bovis_AF2122/97 P--RDGNVDLAALVRAAAAHVLPDAQLTAAEQRAVPGDGARLVTTMTRHP
Rv3800c|M.tuberculosis_H37Rv P--RDGNVDLAALVRAAAAHVLPDAQLTAAEQRAVPGDGARLVTTMTRHP
MLBr_00101|M.leprae_Br4923 P--RDK-TDLAALVRAAVSQVLPGAHLTAAEQRAMPGAGARLVTMLTRHP
MAV_0218|M.avium_104 P--RNGETDLAALVRSAATQVLPDAQLVASEQRAVPGPGARLVTTMTRHP
MAB_0180|M.abscessus_ATCC_1997 PR-EVAGVDFAELVKTAATSVLPGAQLTAFEQRAIPGEGSTLVTTLSRHP
. :* **::*. *:*.: * * ****:*. .: *** ::***
Mflv_1169|M.gilvum_PYR-GCK GGASVQVHARIEESFTLVYDAIVTRGGQQ--TALPTAVGA-----GTVAE
Mvan_5640|M.vanbaalenii_PYR-1 GGAGVQVHARIEESFTLVYDAIVTRGGQQ--TALPTAVGA-----TTVAE
MSMEG_6392|M.smegmatis_MC2_155 GGATVQVHARVEESFTLVYDAIVARANGAGVTALPVAVGAGVAVSGDVAG
TH_4178|M.thermoresistible__bu GGASVQVHARIDESFTLVYDAIVTRGDQP--GVLPAAVGAG----AAIGA
MMAR_5364|M.marinum_M GGASVQVHARIDESFTLVYDALVARGGQ--DAVLPAAVGAGTAVAAGVDG
MUL_4983|M.ulcerans_Agy99 GGASVQVHARIDESFTLVYDALVARGGQ--DAVLPAAVGAGTAVAAAVDG
Mb3830c|M.bovis_AF2122/97 GGASVQVHARIDESFTLVYDALVSRAGS--ESVLPTAVGAATAIAVADGA
Rv3800c|M.tuberculosis_H37Rv GGASVQVHARIDESFTLVYDALVSRAGS--ESVLPTAVGAATAIAVADGA
MLBr_00101|M.leprae_Br4923 GGASVQVHARIDESFTLVYDALVARGGQ--ESVLPTAVGAGTAIASITVP
MAV_0218|M.avium_104 GGASVQVHARIDESFTLVYDALVSRAGQN-VAALPTAVGAGAAIAVAPTV
MAB_0180|M.abscessus_ATCC_1997 GGATVQVHARIGESFTLVYDAVVSRAGQG--GALPFATAAGVATNGSAVV
*** ******: *********:*:*.. .** *..*
Mflv_1169|M.gilvum_PYR-GCK AVAAPVEQ----EQEK-APEFEADNLTAGANLGASFAKWSPDSGETIGDR
Mvan_5640|M.vanbaalenii_PYR-1 VATAPVAV----EEPSGAPEFEADNLTAGANLGASFAKWSPESGETIGER
MSMEG_6392|M.smegmatis_MC2_155 EGAGASVI----EDDEPDAEILQDNLTAGAGMGADFQKWDPNSGETIGQR
TH_4178|M.thermoresistible__bu PQVGSGVE----EEPEEQPEILTDNLTQGANLGAQVAKWSPDSGETVRDR
MMAR_5364|M.marinum_M AVDAVAPSASADVTEESDAETLTDSLTN-RYMPSGMGRWTPDTGETIADR
MUL_4983|M.ulcerans_Agy99 AVDAVAP--SADATEESDAETLTDSLTN-RYMPSGMGRWTPDTGETIADR
Mb3830c|M.bovis_AF2122/97 PVAPETP------AEDADAETLSDSLTT-RYMPSGMTRWSPDSGETIAER
Rv3800c|M.tuberculosis_H37Rv PVAPETP------AEDADAETLSDSLTT-RYMPSGMTRWSPDSGETIAER
MLBr_00101|M.leprae_Br4923 ADAVTVA------AEESDAEILSDSLTN-RYLPSDMGKWSPDSGETIGHR
MAV_0218|M.avium_104 AAPEQPAEAP--VEEDTNAETLSDSLTA-RYLPAGTGKWSPDSGETVAER
MAB_0180|M.abscessus_ATCC_1997 SASAAPSH-AVAVVEEEVPEEIHDNLLSGAGAGADFKKWSKESGEPVIDR
. .* *.* : :* ::**.: .*
Mflv_1169|M.gilvum_PYR-GCK LGAIVGAAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL
Mvan_5640|M.vanbaalenii_PYR-1 LGTIVGAAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL
MSMEG_6392|M.smegmatis_MC2_155 LGTIVGAAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL
TH_4178|M.thermoresistible__bu LALIVGGAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL
MMAR_5364|M.marinum_M LGLIVGSAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL
MUL_4983|M.ulcerans_Agy99 LGLIVGSAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL
Mb3830c|M.bovis_AF2122/97 LGLIVGSAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL
Rv3800c|M.tuberculosis_H37Rv LGLIVGSAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL
MLBr_00101|M.leprae_Br4923 LSTIVAAAMGYEPEDLPWEVPLVELGLDSLMAVRIKNRVEYDFDLPPIQL
MAV_0218|M.avium_104 LGLIVSAAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQL
MAB_0180|M.abscessus_ATCC_1997 LATIVSMAMGYEPEDVPREVPLIELGLDSLMAVRIKNRVEFDFDLPPIQL
*. **. ********:* ****:*****************:*********
Mflv_1169|M.gilvum_PYR-GCK TAVRDANLYAVEKLIAYAVENRDQVEELAETQKGQSAEEIAAAQAELMGG
Mvan_5640|M.vanbaalenii_PYR-1 TAVRDANLYAVEKLIAYAVENRDQVEELAETQKGQTAEEIAAAQAELMGG
MSMEG_6392|M.smegmatis_MC2_155 TAVRDANLYNVEELIRYAIEHRDEVEQIAESQKGKTAEEIAAEQSELLGG
TH_4178|M.thermoresistible__bu TAVRDASLRDVEQLITYAIEHRDEVDQLAEAQKGKTAEEIAAEQAELMGG
MMAR_5364|M.marinum_M TAVRDANLYNVEKLIEYAVEHRDEVEQLHEHQKTQTAEEIARAQAELMHA
MUL_4983|M.ulcerans_Agy99 TAVRDANLYNVEKLIEYAVEHRDEVEQLHEHQKTQTAEEIARAQAELMHA
Mb3830c|M.bovis_AF2122/97 TAVRDANLYNVEKLIEYAVEHRDEVQQLHEHQKTQTAEEIARAQAELLHG
Rv3800c|M.tuberculosis_H37Rv TAVRDANLYNVEKLIEYAVEHRDEVQQLHEHQKTQTAEEIARAQAELLHG
MLBr_00101|M.leprae_Br4923 QAVRDANLYNVEKLIEYAIKHRDDVEQLHEYQKTQTAAAIAKAQMELLSG
MAV_0218|M.avium_104 TAVRDANLYNIEQLITYAIEHRDEVEALHEHQKTLTPEEIAKEQAQLLSG
MAB_0180|M.abscessus_ATCC_1997 QAVRDANLLDVERLVIYALENPDAVHELHDYQQTDEFKAAAPTGGMLSKA
*****.* :*.*: **::: * *. : : *: * * .
Mflv_1169|M.gilvum_PYR-GCK ATTVAELEAKLAEVGHPIA----------------EVPPP----------
Mvan_5640|M.vanbaalenii_PYR-1 ATTVAELEAKLAEAGHPIAADKSTDEVVTA--AGTEAPPSDVAVPAPPSD
MSMEG_6392|M.smegmatis_MC2_155 ASTVAELEAKLAEAGHPLAAKDSEDSENSEDNAAGAAAAAEASAVEGLEI
TH_4178|M.thermoresistible__bu ASTVAEIQEKLVAAGLAVDTGQDGSEQAPDQAAEQAAVLSGATEATATTA
MMAR_5364|M.marinum_M KHDSAPAPAAEAEAEAPES-------------------------------
MUL_4983|M.ulcerans_Agy99 KHDSAPAPAAEAEAEAPES-------------------------------
Mb3830c|M.bovis_AF2122/97 KVG---------KTEPVDS-------------------------------
Rv3800c|M.tuberculosis_H37Rv KVG---------KTEPVDS-------------------------------
MLBr_00101|M.leprae_Br4923 VSP----------VTLPAS-------------------------------
MAV_0218|M.avium_104 ATPASVAAPAPDPQAEPET-------------------------------
MAB_0180|M.abscessus_ATCC_1997 DIEAALTAGAAESVPAEVP-------------------------------
Mflv_1169|M.gilvum_PYR-GCK ---PTDPTGPSAPSIPAPPTDPSGPTG--------------AKPSAAG--
Mvan_5640|M.vanbaalenii_PYR-1 VAVPAPPTDPSGPSIPAPPTDPLGPSAPTAERSSAADGSSRERSSAAG--
MSMEG_6392|M.smegmatis_MC2_155 PPPPTDPTGPGGAPIPPPPSDPSGPAQAASATDAPAG--TVNKATAAA--
TH_4178|M.thermoresistible__bu VVDPQAEPSTQDDAIPPPPTDPRGPVSDSAPAPVANIPPPPTDPSGPNKP
MMAR_5364|M.marinum_M ---EAAAPPASDVPLPPPPTNPAGPSPNGQSSSTPDLK------------
MUL_4983|M.ulcerans_Agy99 ---EAAAPPASDVPLPPPPTNPAGPSPNGQSSSTPDLK------------
Mb3830c|M.bovis_AF2122/97 ---EAG------VALPSP-QNGEQPNPTG---------------------
Rv3800c|M.tuberculosis_H37Rv ---EAG------VALPSP-QNGEQPNPTG---------------------
MLBr_00101|M.leprae_Br4923 ---EAP--------IPPPPTDPTDPPSNG---VQPNLV------------
MAV_0218|M.avium_104 ---QPAPPPPSDTPIPPPPTDPSGPSANG----GQPKP------------
MAB_0180|M.abscessus_ATCC_1997 --AAEPAADSAPPAIAQEATISAETSELAK--------------------
:. .
Mflv_1169|M.gilvum_PYR-GCK --LAAKVLTQEAVTEALGADVPPRDAAERVTFATWAIVTGKSPGGIFNEL
Mvan_5640|M.vanbaalenii_PYR-1 --LAAKVLTQEAVTEALGADVPPRDAAERVTFATWAIVTGKSPGGIFNEL
MSMEG_6392|M.smegmatis_MC2_155 --AAAKVLTQEAVTEALGADVPPRDAAERVTFATWAIVTGKSPGGIFNEL
TH_4178|M.thermoresistible__bu PAAERRVLTQEAVTEALGADVPPQDAAERVTFATWAIVTGKSPGGIFNEL
MMAR_5364|M.marinum_M --GAADALNQEAVAKALNSDVPPRDAAERVVFATWAIVTGKSAGGIFNPL
MUL_4983|M.ulcerans_Agy99 --GAADALNQEAVAKALNADVPPRDAAERVVFATWAIVTGKSAGGIFNPL
Mb3830c|M.bovis_AF2122/97 --------------PALNVDVPPRDAAERVTFATWAIVTGKSPGGIFNEL
Rv3800c|M.tuberculosis_H37Rv --------------PALNVDVPPRDAAERVTFATWAIVTGKSPGGIFNEL
MLBr_00101|M.leprae_Br4923 --AAAEALTSEAVAKVLNSDVPPRDAAERVTFAAWAIVTGKSPGGIFDTL
MAV_0218|M.avium_104 --SLAEALSSEAVTKALNSDVPPRDAAERVTFATWAIVTGKSAGGIFNPL
MAB_0180|M.abscessus_ATCC_1997 ---AAAAMNQEAIAEALNADVPPRDAAERVAFATWAIVTGESPGSIFNAL
.*. ****:******.**:******:*.*.**: *
Mflv_1169|M.gilvum_PYR-GCK PSIADDVAEKIAARLSERADG-TVTAEQVRAARTIQDLSVAVRDEMDSGE
Mvan_5640|M.vanbaalenii_PYR-1 PSIADDVAEKIAQRLSERAEG-TITAEQVKVARTIQDLSSHVRDEMDAGE
MSMEG_6392|M.smegmatis_MC2_155 PTVSEETAKKMAERLSERAEG-TITVEDVLGAKTIEGLATIVREQLEEGV
TH_4178|M.thermoresistible__bu PAIDDATAAKIAERLTERVDEGTISAEDVKAAKTIEELGTTVREYLEGGK
MMAR_5364|M.marinum_M PKLDKDKAAKMAQRLSERAEG-SITTEDVLSSQNIEALAEKVRGYLEAGT
MUL_4983|M.ulcerans_Agy99 PKLDKDKAAKMAQRLSERAEG-SITTEDVLSSQNIEALAEKVRGYLEAGT
Mb3830c|M.bovis_AF2122/97 PRLDDEAAAKIAQRLSERAEG-PITAEDVLTSSNIEALADKVRTYLEAGQ
Rv3800c|M.tuberculosis_H37Rv PRLDDEAAAKIAQRLSERAEG-PITAEDVLTSSNIEALADKVRTYLEAGQ
MLBr_00101|M.leprae_Br4923 PKLDGDTAAKMAQRLSERAEG-TITAEDVLTSENIEALAGKVRNYLEAGQ
MAV_0218|M.avium_104 PKLDADTAAKMAQRLSERADG-PITVEDVQTAETIEALAERVRTYLEAGQ
MAB_0180|M.abscessus_ATCC_1997 PKIDDATAEKLAERLSQRADG-EIPAEEVKLAPTIEALGEVVRSRLEAGK
* : * *:* **::*.: :..*:* : .*: *. ** :: *
Mflv_1169|M.gilvum_PYR-GCK VDGFVRTIRARQEGSNR-------IPVFVFHPAGGSTVVYEPLLKRLPAD
Mvan_5640|M.vanbaalenii_PYR-1 LDGFVRILRARPEGSTR-------VPVFVFHPAGGTTVVYEPLMKRLPAD
MSMEG_6392|M.smegmatis_MC2_155 VDGFVRTLRPPKEGSNA-------VPLFVFHPAGGSTVVYEPLMKRLPAD
TH_4178|M.thermoresistible__bu VDGFVRTIRAPQEGSDR-------LPVFVFHPAGGSTVVYEPLLNRLPPD
MMAR_5364|M.marinum_M IDGFVRTLRPRPEGSSK-------VPVFVFHPAGGSTVVYEPLLNRLPAD
MUL_4983|M.ulcerans_Agy99 IDGFVRTLRPRPEGSSK-------VPVFVFHPAGGSTVVYEPLLNRLPAD
Mb3830c|M.bovis_AF2122/97 IDGFVRTLRARPEAGGK-------VPVFVFHPAGGSTVVYEPLLGRLPAD
Rv3800c|M.tuberculosis_H37Rv IDGFVRTLRARPEAGGK-------VPVFVFHPAGGSTVVYEPLLGRLPAD
MLBr_00101|M.leprae_Br4923 IDGFVRAIRPRAEDSAEGPAGESRVPVFVFHPAGGSTVVYEPLLKRLPAD
MAV_0218|M.avium_104 IDGFVRTLRARPEGSTK-------IPVFVFHPAGGSTVVYEPLLKRLPPD
MAB_0180|M.abscessus_ATCC_1997 IDGFVRTLAPRQEGSTA-------VPVFVFHPAGGSTVVYEPLLKRLPEG
:***** : . * . :*:********:*******: *** .
Mflv_1169|M.gilvum_PYR-GCK TPMYGFERVEGSVEERAAEYIPKLREIQG------DGPYILVGWSLGGAL
Mvan_5640|M.vanbaalenii_PYR-1 TPVYGIERVEGSIEERAREYVPKLMEIQG------NGPYILAGWSLGGAL
MSMEG_6392|M.smegmatis_MC2_155 VPVYGLERVEGSIEERAAEYVPKLLEMH-------KGPFVLAGWSLGGAL
TH_4178|M.thermoresistible__bu TPMYGFERVEGSIEERARQYVPKLLELNGWIDGRRGEPFILAGWSLGGVL
MMAR_5364|M.marinum_M TPMYGFERVEGSIEERAAQYVPKLIEMQG------DGPYILVGWSLGGVL
MUL_4983|M.ulcerans_Agy99 TPMYGFERVEGSIEERAAQYVPKLIEMQG------DGPYILVGWSLGGVL
Mb3830c|M.bovis_AF2122/97 TPMYGFERVEGSIEERAQQYVPKLIEMQG------DGPYVLVGWSLGGVL
Rv3800c|M.tuberculosis_H37Rv TPMYGFERVEGSIEERAQQYVPKLIEMQG------DGPYVLVGWSLGGVL
MLBr_00101|M.leprae_Br4923 TPMYGFERVEGSIEERVAVYVPKLIEMQG------DGPYILAGWSLGGVL
MAV_0218|M.avium_104 TPMYGFERVEGSVQERAAQYVPKLLELNE------DNPFVLVGWSLGGAL
MAB_0180|M.abscessus_ATCC_1997 TPMFGFERVEGTIEERAAKYVPKLMELHD-------GPFILAGWSLGAVL
.*::*:*****:::**. *:*** *:: *::*.*****..*
Mflv_1169|M.gilvum_PYR-GCK AYACAIGLKREGADVRFVGLIDMVRPGEEIPQTKEETRARWDRYALFAQR
Mvan_5640|M.vanbaalenii_PYR-1 AYACAVGLKSQGADVKFVGLIDTVRAGEEVPQTKEEIRARWDRYALFAQR
MSMEG_6392|M.smegmatis_MC2_155 AYACAIGLKQSGADVRFVGLIDTVLPGEPIDQSKEGMRARWDRYARFAER
TH_4178|M.thermoresistible__bu AYACAIGLKQAGADVRFVGLIDAVRAGEEVPQTKEETRARWERYARFAER
MMAR_5364|M.marinum_M AYACAIGLKRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAKFAEK
MUL_4983|M.ulcerans_Agy99 AYACAIGLKRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAKFAEK
Mb3830c|M.bovis_AF2122/97 AYACAIGLRRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEK
Rv3800c|M.tuberculosis_H37Rv AYACAIGLRRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEK
MLBr_00101|M.leprae_Br4923 AYACAIGLRSAGKEVAWVGLIDAVRAGEEIPQTKEEIRKRWDRYARFAER
MAV_0218|M.avium_104 AYACAIGLKRAGADVRFVGLIDTVRAGEEIPQTKEETRKRWDRYARFAER
MAB_0180|M.abscessus_ATCC_1997 AYACAVGLKEAGAEVAWVGNIDGVRPGTPILQTKEETRKRWDRYAAFAQK
*****:**: * :* :** ** * .* : *:** * **:*** **::
Mflv_1169|M.gilvum_PYR-GCK TFNVEIPEIPYEELEALDDGGQVQFILDAVRESGVDIPGGIIEHQRTSYL
Mvan_5640|M.vanbaalenii_PYR-1 TFNVEIPAIPYEQLEELDDEGQVKFVLDAVKDSGVDIPGGIIEHQRTSYL
MSMEG_6392|M.smegmatis_MC2_155 TFNVEIPAIPYEELEKLDDEGQVKYVLEIVKESGVQIPGGIIEHQRTSYL
TH_4178|M.thermoresistible__bu TFNVEIPEIPYEQLEELDDEGQVQLVLDAIAESGVQIPGGIIEHQRTSYL
MMAR_5364|M.marinum_M TFNVTVPAIPYEHLEELDDEGQVRFVLEAVSQSGVEIPAGIIEHQRTSYL
MUL_4983|M.ulcerans_Agy99 TFNVTVPAIPYEHLEELDDEGQVRFVLEAVSQSGVEIPAGIIEHQRTSYL
Mb3830c|M.bovis_AF2122/97 TFNVTIPAIPYEQLEELDDEGQVRFVLDAVSQSGVQIPAGIIEHQRTSYL
Rv3800c|M.tuberculosis_H37Rv TFNVTIPAIPYEQLEELDDEGQVRFVLDAVSQSGVQIPAGIIEHQRTSYL
MLBr_00101|M.leprae_Br4923 TFNVTVPEIPYEQLEELDDEGQVRFVLDVVSQSGVQIPAGIIDHQRTSYL
MAV_0218|M.avium_104 TFNVEIPAIPYEQLEELDDEGQVKFVLDIVQQSGVQIPGGIVEHQRTSYL
MAB_0180|M.abscessus_ATCC_1997 TFNVEIPAIPYEQLEELDDAGQVTFVLEAVKASGVQIPGGIIEHQRTSYL
**** :* ****.** *** *** :*: : ***:**.**::*******
Mflv_1169|M.gilvum_PYR-GCK DNRLLETAEIQPYDGHVTLYMADRYHDDAIFFEPRYAIRQPDGGWGEFVD
Mvan_5640|M.vanbaalenii_PYR-1 DNRALDTAVIENYDGHVTLYMADRYHDDAIMFEPRYATRQPDGGWGRFVA
MSMEG_6392|M.smegmatis_MC2_155 DNRALDTVDIKPYDGHVTLYMADRYHDDAIVFEPAYATRKPDGGWGSFVS
TH_4178|M.thermoresistible__bu DNRMIDTAEIQPYDGHVTLYMADRYHDDAIYFEPRYAIRQPDGGWGEYVS
MMAR_5364|M.marinum_M DNRAIDTAEIHPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVS
MUL_4983|M.ulcerans_Agy99 DNRAIDTAEIHPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVS
Mb3830c|M.bovis_AF2122/97 DNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVS
Rv3800c|M.tuberculosis_H37Rv DNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVS
MLBr_00101|M.leprae_Br4923 DNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRKPDGGWGEYVS
MAV_0218|M.avium_104 DNRALETVQIEPYDGHVTLYMADRYHDDVIEFEPRYAIRQPDGGWGEYVA
MAB_0180|M.abscessus_ATCC_1997 DQRAIDTSTPVKFDGHMTLYMADRYHDDAITFEPAYATRQPDGGWGEFVS
*:* ::* :***:***********.* *** ** *:****** :*
Mflv_1169|M.gilvum_PYR-GCK DLEVVPIGGEHIQAIDEPYIAKVGAHMSEAINLIEAGN--D------
Mvan_5640|M.vanbaalenii_PYR-1 DLEVVPIGGEHIQAIDEPYIAKVGAHMSEAINAIEAES--EGK----
MSMEG_6392|M.smegmatis_MC2_155 DLEVVHIGGEHIQAIDEPYIAKVGAHMSEALNRIEAQA--SKEDGAK
TH_4178|M.thermoresistible__bu DLEIVHIGGEHIQVIDEPYIAKVGAHMSEAINRIEAEE--QVK----
MMAR_5364|M.marinum_M DLEVVPIGGEHIQAIDEPIIAKVGEHMSRAVDNIKAEP--TSEVGK-
MUL_4983|M.ulcerans_Agy99 DLEVVPIGGEHIQAIDEPIIAKVGEHMSRAVDNIKAEP--TSEVGK-
Mb3830c|M.bovis_AF2122/97 DLEVVPIGGEHIQAIDEPIIAKVGEHMSRALGQIEADR--TSEVGKQ
Rv3800c|M.tuberculosis_H37Rv DLEVVPIGGEHIQAIDEPIIAKVGEHMSRALGQIEADR--TSEVGKQ
MLBr_00101|M.leprae_Br4923 DLEVVPIGGEHIQAIDEPIIAKVGEHMSQALNKIEAEQ--KAPK---
MAV_0218|M.avium_104 DLEVVPIGGEHIQVIDEPIIGKVGAHLTDVLNKVEAQTSQTSEVGK-
MAB_0180|M.abscessus_ATCC_1997 DLEVVPVGGEHIQVIDEPIIAKVGAHMSQALRTINAQQAQQA-----
***:* :******.**** *.*** *:: .: ::*