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SFTWDAQAGAVLAPGAHGTVRVLGGPGTGKSSLLVDAAVAQIEAGVNPESVLLLTGSGRLPMAERSALTT ALLRSAGAGPAVREPLVRTVHGYAYAVLRRAAERAGEAPPRLVTSAEQDAIIRELLAGDLADGPRAATAW PAALRPALSTAGFATELRNLLARCAERGVDPQALERLGRRCRRPEWVAAGQFARQYEQVMLLRAAVGTAA PEATTPALGAAELVGAALEAFAVDAELLAAERGRIRVLLVDDAQQLDPQAARLVRVLAAGADLALIAGDP NQAVFGFRGGDPGSLLDGAAPAVTLTTSHRCAPAVARAVSGVAGRLPGSSAGRRIEGAGPGEGSVAVRLA ASAHAEAAAIADALRRAHLVDGVPWSQMAVIVRSVPRAGARLPRALAAAGVPVTAPAASGPLAEQPAVRA LLTVLLATADGLDGQRALALLTGPIGRVDPVSLRQLRRNLQRANAGRPPGDFAELLVEALTGTAPPPGAL FRALRRVRAVLDAAGRCHRDGQDPRYILWAAWHRSGLQRRWLSVSERGGPAAAQAGRDLDSVTALFDITD DYVSRTSGASLRGLVEHVAALQLPGAGPVPVATAEQVSVLSAHAALGREWDFVVIAGLQDGLWPNTVPRG GVLGTQRLLDVLDGVSADASVRAPLLAEERRLLVAAMGRARQRLLVTAVDSDTDGSDHEAALPSPFCYEI AQWAGEDVETAALQPVSAPRVLSAAALVGRLRGVVCAPDGAVDELDRRCAATQLARLAQAGVPGADPASW HGLIPVSTAEPLRGGGDVVTLTPSTMQTLTDCPLRWLAERHGGTDPRDLRSAIGSVVHALIAQPHRSPAE LVAELDRAWRHLPFAAQWHSDNELARHRAMLEAFAQWRANTRGALTEVGVEVEIDGTLSTGDGREVRLRG RVDRLERDAAGRLVIVDVKTGKTPVSKDDAQQHAQLALYQLAVAHGLLGAAGGDAEPGGARLVYVGKAAA SGVVEREQDPLTAAAADQWREALRRAADATAGPQFIARRNDGCTHCPLRPCCPAHADGSGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4148 | - | - | 100% (1042) | helicase, UvrD/Rep family protein |
| M. avium 104 | MAV_4147 | - | 1e-40 | 27.59% (1091) | superfamily protein I DNA and RNA helicases |
| M. avium 104 | MAV_4143 | - | 5e-18 | 28.69% (502) | ATP-dependent DNA helicase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3227c | - | 0.0 | 75.97% (1057) | ATP-dependent DNA helicase |
| M. gilvum PYR-GCK | Mflv_4666 | - | 0.0 | 65.23% (1024) | UvrD/REP helicase |
| M. tuberculosis H37Rv | Rv3202c | - | 0.0 | 75.97% (1057) | ATP-dependent DNA helicase |
| M. leprae Br4923 | MLBr_00637 | uvrD2 | 6e-14 | 25.92% (490) | putative ATP-dependent DNA helicase |
| M. abscessus ATCC 19977 | MAB_3516c | - | 0.0 | 53.77% (1049) | ATP-dependent DNA helicase |
| M. marinum M | MMAR_1358 | - | 0.0 | 74.72% (1060) | ATP-dependent DNA helicase |
| M. smegmatis MC2 155 | MSMEG_1941 | - | 0.0 | 64.40% (1042) | helicase, UvrD/Rep family protein |
| M. thermoresistible (build 8) | TH_3022 | - | 0.0 | 59.65% (622) | PUTATIVE acyl transferase domain protein |
| M. ulcerans Agy99 | MUL_2521 | - | 0.0 | 74.43% (1060) | ATP-dependent DNA helicase |
| M. vanbaalenii PYR-1 | Mvan_1801 | - | 0.0 | 66.93% (1025) | UvrD/REP helicase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4666|M.gilvum_PYR-GCK -------------MSAPQTELTTDALGRRDLRGTVRVLGGPGTGKSSLLV
Mvan_1801|M.vanbaalenii_PYR-1 -------------MSAPHTELSPEALSRRDVRGTVRVLGGPGTGKSSLLV
MSMEG_1941|M.smegmatis_MC2_155 ----------MTTRPAESAPQTASTLLEPGSNGVVRLLGGPGTGKSSLLV
MMAR_1358|M.marinum_M --------------MSLSWGAEARELLTPGSRGLVRVLGGPGTGKSALLV
MUL_2521|M.ulcerans_Agy99 --------------MSLSWGAEARELLTPGSRGLVRVLGGPGTGKSALLV
Mb3227c|M.bovis_AF2122/97 --------------MSHIWGVEAGAALAPGLRGPVLVLGGPGTGKSTLLV
Rv3202c|M.tuberculosis_H37Rv --------------MSHIWGVEAGAALAPGLRGPVLVLGGPGTGKSTLLV
MAV_4148|M.avium_104 --------------MSFTWDAQAGAVLAPGAHGTVRVLGGPGTGKSSLLV
MAB_3516c|M.abscessus_ATCC_199 --------MSAPPPSSRYWDGAAACLLDPDRTGRFVVVGGSGTGKTSLLV
TH_3022|M.thermoresistible__bu MTPITRANSWPDGRIPVLLSAHAEDLLRADARALLDYLDREPAAAVXXXX
MLBr_00637|M.leprae_Br4923 ---MDPMVMVVNPLTAGLDDEQREAVLAP--RGPVCVLAGAGTGKTRTIT
. . . : :.
Mflv_4666|M.gilvum_PYR-GCK DTAVAHIAAGCDPE-SVLLLTGSARLSVQVRASITSA---LLGAG----G
Mvan_1801|M.vanbaalenii_PYR-1 DTAAAHIAAGCDPE-SVLLLTGSSRLSAQARAAITTA---LLGAG----A
MSMEG_1941|M.smegmatis_MC2_155 DTAVQHILAGADPE-SVLLLTGSARLRTAARAAITAR---LLGAG----T
MMAR_1358|M.marinum_M QAAIAHIAAGADPE-SVLLLTGSGRMGMWARSSLTTA---LLRSHTTGTG
MUL_2521|M.ulcerans_Agy99 QAAIAHIAAGADPE-SVLLLTGSGRMGMRARSSLTTA---LLRSHTTGTG
Mb3227c|M.bovis_AF2122/97 EAAVAHIGAGTDPE-SVLLLTGSGRMGMRARSALTTA---LLRSRTNGPC
Rv3202c|M.tuberculosis_H37Rv EAAVAHIGAGTDPE-SVLLLTGSGRMGMRARSALTTA---LLRSRTNGPC
MAV_4148|M.avium_104 DAAVAQIEAGVNPE-SVLLLTGSGRLPMAERSALTTA---LLRSAGAGP-
MAB_3516c|M.abscessus_ATCC_199 DIVAAHTAAGVNPA-SVLVLTGSNRASAELRNRISAA---VFERCAG---
TH_3022|M.thermoresistible__bu RAVIRAADRTELAD-GLRAVADGAEHRLVARSDHSTAPRLAFVFPGQGSQ
MLBr_00637|M.leprae_Br4923 HRIAHLVGAGHVATGQVLAVTFTQRAAAEMRSRLRALG------------
. : :: . * :
Mflv_4666|M.gilvum_PYR-GCK RAAVREPLVRTVHSYAFGVLRLAAQRNGS---PPPRLITSAE--------
Mvan_1801|M.vanbaalenii_PYR-1 RSAVREPLVRTVHSYAFAVLRLAAQRNGS---PPPRLITSAE--------
MSMEG_1941|M.smegmatis_MC2_155 VGVVREPLVRTVHSYAFAVLRLAAQRNGD---PPPRLITSAE--------
MMAR_1358|M.marinum_M RAAVREPLVRSVHSYAYAVLRRAAERTGD---APPRLLTSAE--------
MUL_2521|M.ulcerans_Agy99 RAAVREPLVRSVHSYAYAVLRRAAERTGD---APPRLLTSAE--------
Mb3227c|M.bovis_AF2122/97 RAAIREPVVRTVHSYAYAVLRKAAQRAGD---ALPRLLTSAE--------
Rv3202c|M.tuberculosis_H37Rv RAAIREPVVRTVHSYAYAVLRKAAQRAGD---ALPRLLTSAE--------
MAV_4148|M.avium_104 --AVREPLVRTVHGYAYAVLRRAAERAGE---APPRLVTSAE--------
MAB_3516c|M.abscessus_ATCC_199 -VAIREPMVRTVHSYAFAVLAAHAACQGN---PPPRLITAAE--------
TH_3022|M.thermoresistible__bu WPGMGAAAYRQFAEYRAGVDACAAAFTAAGAPAPLRYLTTPDDPESFCET
MLBr_00637|M.leprae_Br4923 ---AAVQAVSDFGVVRVLTFHAAAHRQLR--YFWPRVIGDTG--------
. . * * : .
Mflv_4666|M.gilvum_PYR-GCK ------------------QDGIIRELLAG-DVEDGPASPVRWPEQLRPAL
Mvan_1801|M.vanbaalenii_PYR-1 ------------------QDGIIRELLAG-DVEDGDASPVRWPERLRPAL
MSMEG_1941|M.smegmatis_MC2_155 ------------------QDGIIRELLAG-DLEDGHRSPVGWPEQLWPAL
MMAR_1358|M.marinum_M ------------------QDAIIRELLAG-DLEDGPSARSAWPRHLLPAL
MUL_2521|M.ulcerans_Agy99 ------------------QDAIIRELLAG-DLEDGPSAGSAWPRHLLPAL
Mb3227c|M.bovis_AF2122/97 ------------------QDAIIRELLAG-DAEDGPAATTTWPAHLRPAL
Rv3202c|M.tuberculosis_H37Rv ------------------QDAIIRELLAG-DAEDGPAATTTWPAHLRPAL
MAV_4148|M.avium_104 ------------------QDAIIRELLAG-DLADGPRAATAWPAALRPAL
MAB_3516c|M.abscessus_ATCC_199 ------------------QDSIVRELLCG-NAEDNSGS---WPASLRPAL
TH_3022|M.thermoresistible__bu EVEGAQFTHAVALARMWRHHGVLPDITVGHSLGEVGAAYIAGAITLADAV
MLBr_00637|M.leprae_Br4923 ----------------------WQLLDSKFATVARAASSVRLHAGTDDVC
: : .
Mflv_4666|M.gilvum_PYR-GCK STVGFATELRDLMAR---CSERGIDPVALQRIGRHA---------GRPEW
Mvan_1801|M.vanbaalenii_PYR-1 STVGFATELRDLMAR---CSERGVDPLALQRIGRAA---------GRPEW
MSMEG_1941|M.smegmatis_MC2_155 TTAGFATELRDLMAR---CTERGVDPIALQRLGRTA---------KRPEW
MMAR_1358|M.marinum_M TTAGFATELRNLLAR---CAERGVDPMELERLGRRS---------GRPEW
MUL_2521|M.ulcerans_Agy99 TTAGFATELRNLLAR---CAERGVDPMELERLGRRS---------GRPEW
Mb3227c|M.bovis_AF2122/97 TTAGFATELRNLLAR---CAERGLDPLELQQLGRRR---------GRPEW
Rv3202c|M.tuberculosis_H37Rv TTAGFATELRNLLAR---CAERGLDPLELQQLGRRR---------GRPEW
MAV_4148|M.avium_104 STAGFATELRNLLAR---CAERGVDPQALERLGRRC---------RRPEW
MAB_3516c|M.abscessus_ATCC_199 ATAGFATGVRDLMAR---CTERGVDARELRAIGRRH---------NRPEW
TH_3022|M.thermoresistible__bu SVVIARAGVVDRLPGRYAVAVLGVDADAARDVIASTPGWLELSVVNAPSS
MLBr_00637|M.leprae_Br4923 DLAGEIEWAKASLIG------PEEYVAAVAAIGRDT---------PLDAA
. : :
Mflv_4666|M.gilvum_PYR-GCK QAAG-----------------RFAQAYEQ---------------------
Mvan_1801|M.vanbaalenii_PYR-1 QAAG-----------------RFAQAYEQ---------------------
MSMEG_1941|M.smegmatis_MC2_155 LAAG-----------------RFAQAYEQ---------------------
MMAR_1358|M.marinum_M AAAG-----------------RFARQYEQ---------------------
MUL_2521|M.ulcerans_Agy99 AAAG-----------------RFARQYEQ---------------------
Mb3227c|M.bovis_AF2122/97 IAAG-----------------QFAQRYEQ---------------------
Rv3202c|M.tuberculosis_H37Rv IAAG-----------------QFAQRYEQ---------------------
MAV_4148|M.avium_104 VAAG-----------------QFARQYEQ---------------------
MAB_3516c|M.abscessus_ATCC_199 IAVA-----------------GLAREYEE---------------------
TH_3022|M.thermoresistible__bu VAVSGDRDAVSAAVARVREQGRFAREITVGFPVHTSILEPLRDDLLRNLP
MLBr_00637|M.leprae_Br4923 QIAS------------------VYAAYEA---------------------
.. .
Mflv_4666|M.gilvum_PYR-GCK --------IMLLRSAVGMAAPQAT----------------VPALGAAELV
Mvan_1801|M.vanbaalenii_PYR-1 --------VMLLRAAVGMAAPQAT----------------VPALGAAELV
MSMEG_1941|M.smegmatis_MC2_155 --------IMLLRSAVGMAAPQAT----------------VPALGAAELV
MMAR_1358|M.marinum_M --------VMLLRAAVGTATPQAT----------------APALGAAELV
MUL_2521|M.ulcerans_Agy99 --------VMLLRAAVGTATPQAT----------------APALGVAELV
Mb3227c|M.bovis_AF2122/97 --------VMLLRGAVGLAAPQAT----------------APALSAAELV
Rv3202c|M.tuberculosis_H37Rv --------VMLLRGAVGLAAPQAT----------------APALSAAELV
MAV_4148|M.avium_104 --------VMLLRAAVGTAAPEAT----------------TPALGAAELV
MAB_3516c|M.abscessus_ATCC_199 --------VMLLRSAVGMAAPQAT----------------VPALGAAELV
TH_3022|M.thermoresistible__bu QAEFADSPVQFIGAATGDVVPAGTGFGPYWYGNLRHLVRFDRAFQTALRC
MLBr_00637|M.leprae_Br4923 ------------LKARGNGVPGVT----------------LLDFDDLLLH
* * .* * :
Mflv_4666|M.gilvum_PYR-GCK GA-ALEAFAMDADLLSAE---RSRVQLLLVDDAQHLDPQAARLVEVLAAG
Mvan_1801|M.vanbaalenii_PYR-1 GA-ALEAFATDADLLAAE---RARVQLLLVDDAQHLDPQAARLVEVLATG
MSMEG_1941|M.smegmatis_MC2_155 GA-ALEALGADDELLDTE---RNRIKLLLVDDAQHLDPQAARLVRALAAG
MMAR_1358|M.marinum_M GS-ALEAFASDPELLAAE---RARLRFLLVDDAQQLDPQAARLVEVLAAG
MUL_2521|M.ulcerans_Agy99 GS-ALEAFASDPELLAAE---RARLRFLLVDDAQQLDPQAARLVEVLAAG
Mb3227c|M.bovis_AF2122/97 GA-ALEAFAVDPELLAAE---RARVRTLLVDDAQQLDPQAARLVRMLAAG
Rv3202c|M.tuberculosis_H37Rv GA-ALEAFAVDPELLAAE---RARVRTLLVDDAQQLDPQAARLVRMLAAG
MAV_4148|M.avium_104 GA-ALEAFAVDAELLAAE---RGRIRVLLVDDAQQLDPQAARLVRVLAAG
MAB_3516c|M.abscessus_ATCC_199 GS-ALETFAVEPGMLAAE---RDRIELLLVDDAQHLDPQAALLVRLLAER
TH_3022|M.thermoresistible__bu GARTFVELSAHPSLLFAMSELLGDTPATLLGSTRRDEPIAETFTANLAAA
MLBr_00637|M.leprae_Br4923 TAAAIENDAAVAEEFRDR------YRCFVVDEYQDVTPLQQRVLSAWLGD
: :: . : ::.. : * .
Mflv_4666|M.gilvum_PYR-GCK --------------AELTVIAGDPHQ-----------------TVFGYRG
Mvan_1801|M.vanbaalenii_PYR-1 --------------AELAVIAGDPHQ-----------------TVFGYRG
MSMEG_1941|M.smegmatis_MC2_155 --------------TGLTVIAGDPDQ-----------------SVFGYRG
MMAR_1358|M.marinum_M --------------AEFALIAGDPNQ-----------------AVFGFRG
MUL_2521|M.ulcerans_Agy99 --------------AEFALIAGDPNQ-----------------AVFGFRG
Mb3227c|M.bovis_AF2122/97 --------------TELALIAGDPNQ-----------------AVFGFRG
Rv3202c|M.tuberculosis_H37Rv --------------TELALIAGDPNQ-----------------AVFGFRG
MAV_4148|M.avium_104 --------------ADLALIAGDPNQ-----------------AVFGFRG
MAB_3516c|M.abscessus_ATCC_199 --------------AGFCVIAGDPNQ-----------------TVFGFRG
TH_3022|M.thermoresistible__bu AVSDPGYDWRAVTPAGPDRLTGFPNAPMRAIPMWATAAPRRIGRAGGVRG
MLBr_00637|M.leprae_Br4923 --------------RDDLTVVGDANQ-----------------TIYSFTG
:.* .. . *
Mflv_4666|M.gilvum_PYR-GCK ADPALLRGD---------GPALILNRSHRCAAPLADAIAAITRR------
Mvan_1801|M.vanbaalenii_PYR-1 ADPALLRGE---------GPALTLTRSHRCANPVADAIGAVGRR------
MSMEG_1941|M.smegmatis_MC2_155 ADPVLLRDDT--------HPAITLTQSYRCAPEIASAITGLGQR------
MMAR_1358|M.marinum_M GEPAGLLGG--PLDGG---PAVTLTMSHRCAPAVARAVSGIARR------
MUL_2521|M.ulcerans_Agy99 GEPAGLLGG--PLDGG---PAVTLTMSHRCAPAVARAVSGIARR------
Mb3227c|M.bovis_AF2122/97 GEPTGLLADDPPPAGGAPIPSVTLTVSHRCAPAVARAVTGIARR------
Rv3202c|M.tuberculosis_H37Rv GEPTGLLADDPPPAGGAPIPSVTLTVSHRCAPAVARAVTGIARR------
MAV_4148|M.avium_104 GDPGSLLDG--------AAPAVTLTTSHRCAPAVARAVSGVAGR------
MAB_3516c|M.abscessus_ATCC_199 ADTQLLQVS-----ADSRTTMIELDGSHRCAAPIAELANSVARR------
TH_3022|M.thermoresistible__bu EEAPGLRIA-----AEVWEPVAAQPGPASAATPVPVALLELGDTGRLGGW
MLBr_00637|M.leprae_Br4923 ASPCFLLDFP---RRFPDATVVRLERDYRSTPQVVSLANQVIAA------
.. * . .: : :
Mflv_4666|M.gilvum_PYR-GCK ---LPGADASREFTG-RAEQGTLAVR---IAASPHAESALIADALRRAHL
Mvan_1801|M.vanbaalenii_PYR-1 ---LPGAEATREFTG-SDAPGSVTVQ---IAASPHAESALIADALRRAHL
MSMEG_1941|M.smegmatis_MC2_155 ---LPGVSDTRHWTGNPQREGTVTVR---LAASTHAEGTMIADALRRAHL
MMAR_1358|M.marinum_M ---LPGGSAGRHIDGTGTEDGSVTVR---LAATAHAEAAAIADALRRAHL
MUL_2521|M.ulcerans_Agy99 ---LPGGSAGRHIDGTGTEDGSVTVR---LAATAHAEAAAIADALRRAHL
Mb3227c|M.bovis_AF2122/97 ---LPGRSVGRRIEGTGTEVGSVTVR---LAGSAHAEAAMIADALRRAHL
Rv3202c|M.tuberculosis_H37Rv ---LPGRSVGRRIEGTGTEVGSVTVR---LAGSAHAEAAMIADALRRAHL
MAV_4148|M.avium_104 ---LPGSSAGRRIEGAGPGEGSVAVR---LAASAHAEAAAIADALRRAHL
MAB_3516c|M.abscessus_ATCC_199 ---LPGSSPARVIHGVENGPAAVRLA---AVPTETAEASLVVDLLRRSHL
TH_3022|M.thermoresistible__bu LRELLGNRPDVVLVGPEAAEVAVVAAPESDTAAPEAGVAAITELVRAGGL
MLBr_00637|M.leprae_Br4923 ---AHGRVADSKFQLSGQREPGPAAS-FHEYSDEPAEAAAVAASIARLIE
* * : :. :
Mflv_4666|M.gilvum_PYR-GCK VD----------------GVPWDRMAVIVRSVPRTGASLGRALAAAG--V
Mvan_1801|M.vanbaalenii_PYR-1 VD----------------GVPWSQMAVIVRSVPRMGAALGRALTAAG--V
MSMEG_1941|M.smegmatis_MC2_155 VD----------------GIPWSQMAVIVRSVPRVGTALARALTAAG--V
MMAR_1358|M.marinum_M VD----------------GVPWSQMAVIVRSVPRVAARLPRALAAAG--V
MUL_2521|M.ulcerans_Agy99 VD----------------GVPWSQMAVIVRSVPRVAARLPRALAAAG--V
Mb3227c|M.bovis_AF2122/97 ID----------------GVPWSQMAVIVRSVPR-AVRLPRALAAAG--V
Rv3202c|M.tuberculosis_H37Rv ID----------------GVPWSQMAVIVRSVPR-AVRLPRALAAAG--V
MAV_4148|M.avium_104 VD----------------GVPWSQMAVIVRSVPRAGARLPRALAAAG--V
MAB_3516c|M.abscessus_ATCC_199 ID----------------GVPWSRMAVIVRSVPRSGAALCRALQSAG--V
TH_3022|M.thermoresistible__bu RYPAAPGPHCRDVWLVTVGAEQVHPDDPVAPVPAAVAAMHRSLGLENPQI
MLBr_00637|M.leprae_Br4923 FG-----------------TSPSEIAVLYR-VNAQSEAYEEALTEVG--I
. * .:* . :
Mflv_4666|M.gilvum_PYR-GCK PVEDPHPDVPLA------NQPAVQALLT--VLEATAEK-LDGERALA---
Mvan_1801|M.vanbaalenii_PYR-1 PLDLPQPEVPLA------EQPAVRALLT--VLEATADG-LDGERALA---
MSMEG_1941|M.smegmatis_MC2_155 PVQDNGTDVPVG------RQPAAAALLT--VLDVTATGHLDADSAVA---
MMAR_1358|M.marinum_M PVSIPPIGGSLA------EEPAVGALLT--VLAATAEG-LNADQALA---
MUL_2521|M.ulcerans_Agy99 PVSIPPIGGSLA------EEPAVGALLT--VLAATAEG-LNADQALA---
Mb3227c|M.bovis_AF2122/97 PVAPPAVGGPLS------AEPAVRALLT--VLEATADG-LDGDQALL---
Rv3202c|M.tuberculosis_H37Rv PVAPPAVGGPLS------AEPAVRALLT--VLEATADG-LDGDQALL---
MAV_4148|M.avium_104 PVTAPAASGPLA------EQPAVRALLT--VLLATADG-LDGQRALA---
MAB_3516c|M.abscessus_ATCC_199 PVHAESYDGPVA------SVPAVHALLL--AVSAAQGG-VTHEDAVT---
TH_3022|M.thermoresistible__bu PFHHLDLEQGVGSDTARDTDPAVAALLMDAVLSATGGGGLAIRTTGAGAV
MLBr_00637|M.leprae_Br4923 AYQVRGGEGFFN------RQEIKQALLA----------------------
. . ***
Mflv_4666|M.gilvum_PYR-GCK ------------------------LVTGPIGRVDPVSLRQLRR-TLRRG-
Mvan_1801|M.vanbaalenii_PYR-1 ------------------------LVTGPIGRVDPISLRQLRR-ALRRA-
MSMEG_1941|M.smegmatis_MC2_155 ------------------------LLTGPIGRVDPVTLRQLRR-ALRRAD
MMAR_1358|M.marinum_M ------------------------LITGPIGRVDPVTLRQLRR-TLRRAV
MUL_2521|M.ulcerans_Agy99 ------------------------LITGPIGRVDPVRLRQLRR-TLRRAV
Mb3227c|M.bovis_AF2122/97 ------------------------LLTGPIGGVDPVSLRQLRR-TLQRAR
Rv3202c|M.tuberculosis_H37Rv ------------------------LLTGPIGGVDPVSLRQLRR-TLQRAR
MAV_4148|M.avium_104 ------------------------LLTGPIGRVDPVSLRQLRR-NLQRAN
MAB_3516c|M.abscessus_ATCC_199 ------------------------LATGPLGRVDPVALRRLRR-QLLRAE
TH_3022|M.thermoresistible__bu LYRRGLRDVPAPPPLDRPGLLDEVVITGGAGAIGLHYARQLARRGAKRIV
MLBr_00637|M.leprae_Br4923 ---------------------------------------------LQRSA
*
Mflv_4666|M.gilvum_PYR-GCK VTAPD-RGFGELLVEALER---------DVAALPDEHARALRRLRAVLTS
Mvan_1801|M.vanbaalenii_PYR-1 APESP-GGFSDLLVDALQR---------DTPALADGQARALRRVCAVLTA
MSMEG_1941|M.smegmatis_MC2_155 GSQPP-RDFGDLLVDAIER---------EPKGLSAEHARTLRRLRAVLTA
MMAR_1358|M.marinum_M AGRSP-EDFGDLLVATLSEDGRPAVGSAGSNQPPGPQFGPLRRVRAVLAA
MUL_2521|M.ulcerans_Agy99 AGRSP-EDFGDLLVATLSEDGRPAVGSAGSNQPPGPQFGPLRRVRAVLAA
Mb3227c|M.bovis_AF2122/97 PGQTS-RKFGDLLVEVLG----------GDAPPSGPGSRALRRVRAVLTA
Rv3202c|M.tuberculosis_H37Rv PGQTS-RKFGDLLVEVLG----------GDAPPSGPGSRALRRVRAVLTA
MAV_4148|M.avium_104 AGRPP-GDFAELLVEALT----------GTAPPPGALFRALRRVRAVLDA
MAB_3516c|M.abscessus_ATCC_199 EAAGGERGSAELLRAVLVEADET-----HLAALTDIQAAPLRRVRAVIGA
TH_3022|M.thermoresistible__bu LLSRRPVDPAELAALAAPTGAEVLS---VSCDLTDPDAVXXXXVRAVLTA
MLBr_00637|M.leprae_Br4923 ERSSQ----------------------------TEPNSPLSDVVRGVLEP
. : .*: .
Mflv_4666|M.gilvum_PYR-GCK ARRSAEQG----GDPRQTLWQAWNRSGLQKRWLAAAERGGPAAAQAERDL
Mvan_1801|M.vanbaalenii_PYR-1 ARRSAREG----SDPRHTLWQAWHRSGLQKRWLAASERGGPAGAQADRDL
MSMEG_1941|M.smegmatis_MC2_155 ARRSDASG----ADPRYTLWQAWHASGLQRRWLAASERGGSVGAQADRDL
MMAR_1358|M.marinum_M ATRCHRAG----QDPRYILWAAWHRSGLQNRWLAAIDRGGPAGVQATRNL
MUL_2521|M.ulcerans_Agy99 ATRCHRAG----QDPRYILWAAWHRSGLQNRWLAAIDRGGPAGVQATRNL
Mb3227c|M.bovis_AF2122/97 AARCHRSGSLGGQDPRHTLWAAWQRSGLQRRWLAASEHGGAAAVQATRDL
Rv3202c|M.tuberculosis_H37Rv AARCHRSGSLGGQDPRHTLWAAWQRSGLQRRWLAASEHGGAAAVQATRDL
MAV_4148|M.avium_104 AGRCHRDG----QDPRYILWAAWHRSGLQRRWLSVSERGGPAAAQAGRDL
MAB_3516c|M.abscessus_ATCC_199 AREATASG----ASVLDVLWAAWTRSGLQRRWDGLSQRGGPLGAQADRDL
TH_3022|M.thermoresistible__bu AERAHRHG----GDPREVLWQAWHRSGLQRRWLAASERGGVAGVQADRDL
MLBr_00637|M.leprae_Br4923 LGLTAEKP---------------------------------VGSRARDRW
. :*
Mflv_4666|M.gilvum_PYR-GCK DAVTALFDVAEQYVERTAGASLRGLIDHITGLSLPPARGD-ARSGDAVAL
Mvan_1801|M.vanbaalenii_PYR-1 DAVTAMFDVAEQYVARTAGASLRGLVDHITALALPPARRD-EAAPDAVAL
MSMEG_1941|M.smegmatis_MC2_155 DAVTTLFDVADQYVNRTAGASLRGLVDHVTRLGAAVARTEPETAAEAVAV
MMAR_1358|M.marinum_M EAVTALFDITDQYVSRTSGASLSGLLEHVAALQLPRVSEEPVAQNEQVRV
MUL_2521|M.ulcerans_Agy99 EAVTALFDITDQYVSRTSGASLSGLLEHVAALQLPRVSEEPVAQNEQVGV
Mb3227c|M.bovis_AF2122/97 ETVTALFDITDHYVSRTSGASLRGLVEHVTALQLPVVRPEPAAPTEQVMV
Rv3202c|M.tuberculosis_H37Rv ETVTALFDITDHYVSRTSGASLRGLVEHVTALQLPVVRPEPAAPTEQVMV
MAV_4148|M.avium_104 DSVTALFDITDDYVSRTSGASLRGLVEHVAALQLPGAGPVPVATAEQVSV
MAB_3516c|M.abscessus_ATCC_199 DAVSSLFDLASEHVARTPGIGVTGLIDHIRSLALVGQRTT-RLEPDAVAI
TH_3022|M.thermoresistible__bu DAVTAFFDAAEQYVARTAGATLRGLIDHLTTLGPAAPARDQSARRDAVAV
MLBr_00637|M.leprae_Br4923 EALTALAELADDEVAQHPRLDLPGLLAELR----LRADARHPPVVQGVTL
:::::: : :.. * : . : **: .: : * :
Mflv_4666|M.gilvum_PYR-GCK ISAHAALSGEWDFVVLAGLQEGLWPNVSPRGGVLATQHLVDVIDGVAAPG
Mvan_1801|M.vanbaalenii_PYR-1 LSAHSALGHEWEFVVLAGVQEGLWPNVSPRGGVLATQQLVDVIDGVCAPG
MSMEG_1941|M.smegmatis_MC2_155 LSVHGALAGEWDFVVIAGVQEGLWPNMIPRGGVLGTQHLVDVLDGVADMT
MMAR_1358|M.marinum_M LSAHAALGHEWDLVVIAGLQDGLWPNTIPRGGVLATQRLLDELDGVSG--
MUL_2521|M.ulcerans_Agy99 LSAHAALGHEWDLVVIAGLQDGSWPNTIPRGGVLATQRLLDELDGVSG--
Mb3227c|M.bovis_AF2122/97 LSAHAALGHEWDLVVIAGLQDGLWPNTVPRGGVLGTQRLLDELDGVTK--
Rv3202c|M.tuberculosis_H37Rv LSAHAALGHEWDLVVIAGLQDGLWPNTVPRGGVLGTQRLLDELDGVTK--
MAV_4148|M.avium_104 LSAHAALGREWDFVVIAGLQDGLWPNTVPRGGVLGTQRLLDVLDGVSA--
MAB_3516c|M.abscessus_ATCC_199 VSAHAAVGREWDVVAIPGVQEGLWPNTAVRGGVLRTQELMDVLAGIEH--
TH_3022|M.thermoresistible__bu LSAHAALDREWDLVVIAGLQDGLWPNTVPRGGVLATQQLVDVLDGVADGS
MLBr_00637|M.leprae_Br4923 ASLHAVKGLEWDAVFLVGLADG----TLPISRALAHGAESEPVE------
* *.. **: * : *: :* . .* : :
Mflv_4666|M.gilvum_PYR-GCK QR-LSSRAPLLAEERRLLIAAMGRARSRVLVTAVDSDS---GDEAALPSP
Mvan_1801|M.vanbaalenii_PYR-1 QHTLSSRAPLLAEEWRLLIAAMGRARSRLLVTAVDSDC---GDDAMLPSS
MSMEG_1941|M.smegmatis_MC2_155 DRTVSTRAPLVAEERRLLMAAMGRARTRVMITAVDSDT---GDESLLPSP
MMAR_1358|M.marinum_M --NASARAPLLAEERRLLLAAMGRARRQLLVTAVDGDTSGGGQQAALPSE
MUL_2521|M.ulcerans_Agy99 --NASARAPLLAEERRLLLAAMGRARRQLLVTAVDGDTSGGGQQAALPSE
Mb3227c|M.bovis_AF2122/97 --DASMRAPLLAEERRLLVTAMGRARRRLLVTAVDSDAGGGGHEAVLPSA
Rv3202c|M.tuberculosis_H37Rv --DASMRAPLLAEERRLLVTAMGRARRRLLVTAVDSDAGGGGHEAVLPSA
MAV_4148|M.avium_104 --DASVRAPLLAEERRLLVAAMGRARQRLLVTAVDSDTDGSDHEAALPSP
MAB_3516c|M.abscessus_ATCC_199 AAHVDGSAVALAEERRLLLLAVGRAARRVLITAVENENADMGGGPAMASR
TH_3022|M.thermoresistible__bu DPVVSRRAPLLAEERRLLIAAMGRARSRLLVTAVDSDD---GDESLLPSP
MLBr_00637|M.leprae_Br4923 ------------EERRLLYVGITRARVYLALSWALSRTPG-GRQSRKPSR
** *** .: ** : :: . . . . .*
Mflv_4666|M.gilvum_PYR-GCK FCHELAAMAT-EPVPEPALPIRAPRVLSPAAVVGRLRSVVCAGSDEVSED
Mvan_1801|M.vanbaalenii_PYR-1 FCHELAALAT-EPQSQPAPPVRAPRVLAPSALVGRLRSVVCAAPGAVDDV
MSMEG_1941|M.smegmatis_MC2_155 FCAEISAWAT-EPVAEP--PLVAPRVLAPSALVGRLRAVVCAPDGAVDDD
MMAR_1358|M.marinum_M FFFEIAQWANGDSQAVAAPPVSAPRVLSAAAVVGRLRGVVCAPDGAVDDA
MUL_2521|M.ulcerans_Agy99 FFFEIAQWANGDSQAVAAPPVSAPRVLSAAAVVGRLRGVVCAPDGAVDDA
Mb3227c|M.bovis_AF2122/97 FFFEIAQWADGDGEPVAMQPVSAPRVLSAAAVVGRLRAVVCAPACAVDDA
Rv3202c|M.tuberculosis_H37Rv FFFEIAQWADGDGEPVAMQPVSAPRVLSAAAVVGRLRVVVCAPACAVDDA
MAV_4148|M.avium_104 FCYEIAQWAGEDVETAALQPVSAPRVLSAAALVGRLRGVVCAPDGAVDEL
MAB_3516c|M.abscessus_ATCC_199 FLTELMAAHPEWVISEYRPGAAQSRVLTAANLVGELRAVVTAPVEAVTDA
TH_3022|M.thermoresistible__bu FCAELAALAT-EPEAATPAPLPAPRVLTAAALVGRLRSVVCAAPDTVDDE
MLBr_00637|M.leprae_Br4923 FLNDIAPQMGQNPASSR----------SRRNRTATLRCRICKN----DLT
* :: . : .. ** :
Mflv_4666|M.gilvum_PYR-GCK ERVCAAAQLARLATAGVHGADPSSWYGARELSSDEPLWDGDDHVVTLSPS
Mvan_1801|M.vanbaalenii_PYR-1 ERDCAAAQLARLAEAGVHGADPASWYGSRELSSAEPLWEDGEQVVTLSPS
MSMEG_1941|M.smegmatis_MC2_155 ARACAAAQLARLAAAGVPGADPSQWHAMTSLTTEEPLWSEPGHVVTLSPS
MMAR_1358|M.marinum_M ARQCAATQLARLAKAGVAGADPAGWHGLIPVSTTAALY-GAGDVVTLTPS
MUL_2521|M.ulcerans_Agy99 ARQCAATQLARLAKAGVAGADPAGWHGLIPVSTTAALY-GAGDVVTLTPS
Mb3227c|M.bovis_AF2122/97 DRDCAATQLARLAKAGVPGADPSEWHGLAPVSTSDPLC-DSDDLVTLTPS
Rv3202c|M.tuberculosis_H37Rv DRDCAATQLARLAKAGVPGADPSEWHGLAPVSTSDPLC-DSDDLVTLTPS
MAV_4148|M.avium_104 DRRCAATQLARLAQAGVPGADPASWHGLIPVSTAEPLR-GGGDVVTLTPS
MAB_3516c|M.abscessus_ATCC_199 RRRAAARQLARLAAAGVPGADPESWYGLGDVSDERPLWLAEDGPVRVSPS
TH_3022|M.thermoresistible__bu VRAGAATQLARLAAAGVPGADPAQWYAMTPLSTGEPLWDGPGQSVTLSPS
MLBr_00637|M.leprae_Br4923 TPAAVMLQRCQICAADVD--------------------------------
. * .::. *.*
Mflv_4666|M.gilvum_PYR-GCK TLQMLADCPLRWLLERHGGARGRDVRSTLGSLVHALVSESGTAESVLLDE
Mvan_1801|M.vanbaalenii_PYR-1 TLQMLSDCPLRWLLERHGGSRGRDVRSTLGSLVHALVSESGRTESQLLNG
MSMEG_1941|M.smegmatis_MC2_155 TLQMLTDCPLRWLLERHGGDDGRDVRSTVGSLVHALVSEPGKTESQLVNE
MMAR_1358|M.marinum_M TLQTLNDCPLRWLAERHGGTNPRDLRATIGSVLHALIAEPGASEEQLLAE
MUL_2521|M.ulcerans_Agy99 TLQTLNDCPLRWLAERHGGTNPRDLRATIGSVLHALIAEPGASEEQLLAE
Mb3227c|M.bovis_AF2122/97 TLQALNDCPLRWLAERHGGTNTRELPSAVGSVLHALFAEPGRSESQLLAE
Rv3202c|M.tuberculosis_H37Rv TLQALNDCPLRWLAERHGGTNTRELPSAVGSVLHALFAEPGRSESQLLAE
MAV_4148|M.avium_104 TMQTLTDCPLRWLAERHGGTDPRDLRSAIGSVVHALIAQPHRSPAELVAE
MAB_3516c|M.abscessus_ATCC_199 NVETLMACPLRWMLERHGGTDLTDPRRALGTLVHELVGVHAEDSDAMCRA
TH_3022|M.thermoresistible__bu TLQTLVDCPLRWLLERHGGTDGRDVRSTVGSLVHALAAGRYRTEGQLLAE
MLBr_00637|M.leprae_Br4923 --------------------------------------------------
Mflv_4666|M.gilvum_PYR-GCK LDKVWGKLPFDAQWHSDNERIRHLEMLATFLKWRSDTRGELTEVGTEIDV
Mvan_1801|M.vanbaalenii_PYR-1 LEKVWEELPFDAQWYSDNERVRHLEMLSTFLRWREGTRGELTEVGTEIEV
MSMEG_1941|M.smegmatis_MC2_155 LEKVWDDLPYDAKWYSDNELARHRAMLETFTRWREDTRRQLTEVATEIPV
MMAR_1358|M.marinum_M LARVWKLLPFEADWFSSNELARHRAMIQAFVEWRGQTRSELTEVGVEIDI
MUL_2521|M.ulcerans_Agy99 LARVWKLLPFEADWFSSNELARHRAMIQAFVEWRGQTRSELTEVGVEIDI
Mb3227c|M.bovis_AF2122/97 LDRVWGHLPFGAQWYSANELARHRAMIQAFVQWRAQSRSELTEVGVEVDI
Rv3202c|M.tuberculosis_H37Rv LDRVWGHLPFGAQWYSANELARHRAMIQAFVQWRAQSRSELTEVGVEVDI
MAV_4148|M.avium_104 LDRAWRHLPFAAQWHSDNELARHRAMLEAFAQWRANTRGALTEVGVEVEI
MAB_3516c|M.abscessus_ATCC_199 LDKAWESMPFESQWYARNELRRHHELLEAFTTWRASTRGELTEVGREIGV
TH_3022|M.thermoresistible__bu LERVWDQLPFESRWYADNELSRHRAMLQTFMRWRERTRRELTEVAAEIAV
MLBr_00637|M.leprae_Br4923 -----------------------EELLLQLKAWRLSTAKEQNVPAYVVLT
:: : ** : . . :
Mflv_4666|M.gilvum_PYR-GCK DGVVAGGEGDGPGVRVRGRLDRLERDSEGRLVVVDVKTGKSPVSKDDAQA
Mvan_1801|M.vanbaalenii_PYR-1 DGQIAAPDGELPAVRLRGRLDRLERDSEGRLVVIDLKTGKSPVSKDDAQS
MSMEG_1941|M.smegmatis_MC2_155 EGIVVEPGENTPGVRVRGRLDRLERDEAGRLVVVDLKTGKSPVTKDDAQN
MMAR_1358|M.marinum_M DGVLDAARDDGGAIRLRGRVDRLERDGAGRLVIVDIKTAKTPVSKDDAQQ
MUL_2521|M.ulcerans_Agy99 DGVLDAARDDGGAIRLRGRVDRLERDGAGRLVILDIKTAKTPVSKDDAQQ
Mb3227c|M.bovis_AF2122/97 DGALEDGSGQARKIRLRGRADRLERDPAGRLVIVDIKTGKTPVSKDDAQQ
Rv3202c|M.tuberculosis_H37Rv DGALEDGSGQARKIRLRGRADRLERDPAGRLVIVDIKTGKTPVSKDDAQQ
MAV_4148|M.avium_104 DGTLSTG--DGREVRLRGRVDRLERDAAGRLVIVDVKTGKTPVSKDDAQQ
MAB_3516c|M.abscessus_ATCC_199 DGVLSRAG--QPQVRLVGRIDRLERDAEGRPVVIDIKTGKSPATKDDAQQ
TH_3022|M.thermoresistible__bu DGVLVDGADTTPEIRVRGRLDRLERDADGRLVVVDLKTGKSPVTKNDAQR
MLBr_00637|M.leprae_Br4923 D------------NTLIAIAELLPADEAALIAVPGMSVRKIEQYGSDVLQ
: : . : * * . .: .:.. * .*.
Mflv_4666|M.gilvum_PYR-GCK HAQLAMYQLAVAAGLIADG---DEPGGGRLVYLGKT-TGGRATERHQDAV
Mvan_1801|M.vanbaalenii_PYR-1 HAQLAMYQLAVAAGLLADG---DEPGGGRLVYLGKT-TGGGATERHQDAL
MSMEG_1941|M.smegmatis_MC2_155 HAQLAMYQLAVAAGLLDDG---DEPGGGKLVYLGKA-GAAGATEREQDPL
MMAR_1358|M.marinum_M NAQLAMYQLAVAEGMVEAG---AEPGGARLVYPGKS-AAAGAAQRDQDPL
MUL_2521|M.ulcerans_Agy99 NAQLAMYQLAVAEGMVEAG---AEPGGARLVYPGKS-AAAGAAQRDQDPL
Mb3227c|M.bovis_AF2122/97 HAQLAMYQLAVAEGLVRAG---DEPGGARLVYVGKS-GAAGVAERKQDPL
Rv3202c|M.tuberculosis_H37Rv HAQLAMYQLAVAEGLVRAG---DEPGGARLVYVGKS-GAAGVAERKQDPL
MAV_4148|M.avium_104 HAQLALYQLAVAHGLLGAAGGDAEPGGARLVYVGKA-AASGVVEREQDPL
MAB_3516c|M.abscessus_ATCC_199 HAQLAAYQVAAAEGLIEGEP-AGAPGGGRLVYIAKPNLDDGATQRHQDPL
TH_3022|M.thermoresistible__bu HAQLAMYQLAVAAGLLPAG---DIPGGGRLVYLGRP-TGGGATEREQDPL
MLBr_00637|M.leprae_Br4923 LVRCRAVAVRTQT-------------------------------------
.: : .
Mflv_4666|M.gilvum_PYR-GCK TPEVRELWEARVHEAAAATQGPSFVARVNDGCAHCPVRATCPAQNSRSQP
Mvan_1801|M.vanbaalenii_PYR-1 TPDGRAEWDEQVHRAAAATQGPQFTARVNDGCAHCPVRAMCPAQN-RSDT
MSMEG_1941|M.smegmatis_MC2_155 TPDKRAEWLETVGEAAAATAGPRFVARVNNGCANCPVRSSCPAQANGDRP
MMAR_1358|M.marinum_M TPAARDQWRNLVRQAAEAAAGPHFIARRNDGCSHCPIRPSCPAHTDRSPR
MUL_2521|M.ulcerans_Agy99 TPAARDQWRNLVRQAAEAAAGPHFIARRNDGCSHCPIRPSCPAHTDRSPR
Mb3227c|M.bovis_AF2122/97 TPAARDEWRNLVRQLAAATAGPQFIARRNDGCTHCPLRPGCPAHVRGSAP
Rv3202c|M.tuberculosis_H37Rv TPAARDEWRNLVRQLAAATAGPQFIARRNDGCTHCPLRPGCPAHVRGSAP
MAV_4148|M.avium_104 TAAAADQWREALRRAADATAGPQFIARRNDGCTHCPLRPCCPAHADGSGR
MAB_3516c|M.abscessus_ATCC_199 TPAAQDAWRESIHNAAASTQGPIFVARVNDGCGHCPLRTCCPAQTDGQAV
TH_3022|M.thermoresistible__bu TPETAAGWRDTVAQAADATRGPRFAARINDGCAHCPVRFSCPAQAAQAGS
MLBr_00637|M.leprae_Br4923 --------------------------------------------------
Mflv_4666|M.gilvum_PYR-GCK ---
Mvan_1801|M.vanbaalenii_PYR-1 ---
MSMEG_1941|M.smegmatis_MC2_155 ---
MMAR_1358|M.marinum_M ---
MUL_2521|M.ulcerans_Agy99 ---
Mb3227c|M.bovis_AF2122/97 ---
Rv3202c|M.tuberculosis_H37Rv ---
MAV_4148|M.avium_104 ---
MAB_3516c|M.abscessus_ATCC_199 CQS
TH_3022|M.thermoresistible__bu ERP
MLBr_00637|M.leprae_Br4923 ---