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MSLSWGAEARELLTPGSRGLVRVLGGPGTGKSALLVQAAIAHIAAGADPESVLLLTGSGRMGMWARSSLT TALLRSHTTGTGRAAVREPLVRSVHSYAYAVLRRAAERTGDAPPRLLTSAEQDAIIRELLAGDLEDGPSA RSAWPRHLLPALTTAGFATELRNLLARCAERGVDPMELERLGRRSGRPEWAAAGRFARQYEQVMLLRAAV GTATPQATAPALGAAELVGSALEAFASDPELLAAERARLRFLLVDDAQQLDPQAARLVEVLAAGAEFALI AGDPNQAVFGFRGGEPAGLLGGPLDGGPAVTLTMSHRCAPAVARAVSGIARRLPGGSAGRHIDGTGTEDG SVTVRLAATAHAEAAAIADALRRAHLVDGVPWSQMAVIVRSVPRVAARLPRALAAAGVPVSIPPIGGSLA EEPAVGALLTVLAATAEGLNADQALALITGPIGRVDPVTLRQLRRTLRRAVAGRSPEDFGDLLVATLSED GRPAVGSAGSNQPPGPQFGPLRRVRAVLAAATRCHRAGQDPRYILWAAWHRSGLQNRWLAAIDRGGPAGV QATRNLEAVTALFDITDQYVSRTSGASLSGLLEHVAALQLPRVSEEPVAQNEQVRVLSAHAALGHEWDLV VIAGLQDGLWPNTIPRGGVLATQRLLDELDGVSGNASARAPLLAEERRLLLAAMGRARRQLLVTAVDGDT SGGGQQAALPSEFFFEIAQWANGDSQAVAAPPVSAPRVLSAAAVVGRLRGVVCAPDGAVDDAARQCAATQ LARLAKAGVAGADPAGWHGLIPVSTTAALYGAGDVVTLTPSTLQTLNDCPLRWLAERHGGTNPRDLRATI GSVLHALIAEPGASEEQLLAELARVWKLLPFEADWFSSNELARHRAMIQAFVEWRGQTRSELTEVGVEID IDGVLDAARDDGGAIRLRGRVDRLERDGAGRLVIVDIKTAKTPVSKDDAQQNAQLAMYQLAVAEGMVEAG AEPGGARLVYPGKSAAAGAAQRDQDPLTPAARDQWRNLVRQAAEAAAGPHFIARRNDGCSHCPIRPSCPA HTDRSPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1358 | - | - | 100% (1057) | ATP-dependent DNA helicase |
| M. marinum M | MMAR_1359 | - | 8e-27 | 24.32% (1073) | ATP-dependent DNA helicase |
| M. marinum M | MMAR_1364 | uvrD2 | 2e-11 | 34.52% (168) | ATP-dependent DNA helicase II UvrD2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3227c | - | 0.0 | 76.98% (1060) | ATP-dependent DNA helicase |
| M. gilvum PYR-GCK | Mflv_4666 | - | 0.0 | 61.80% (1042) | UvrD/REP helicase |
| M. tuberculosis H37Rv | Rv3202c | - | 0.0 | 76.98% (1060) | ATP-dependent DNA helicase |
| M. leprae Br4923 | MLBr_00153 | uvrD | 5e-11 | 22.15% (578) | putative ATP-dependent DNA helicase |
| M. abscessus ATCC 19977 | MAB_3516c | - | 0.0 | 51.13% (1064) | ATP-dependent DNA helicase |
| M. avium 104 | MAV_4148 | - | 0.0 | 74.72% (1060) | helicase, UvrD/Rep family protein |
| M. smegmatis MC2 155 | MSMEG_1941 | - | 0.0 | 61.47% (1051) | helicase, UvrD/Rep family protein |
| M. thermoresistible (build 8) | TH_3022 | - | 0.0 | 58.10% (611) | PUTATIVE acyl transferase domain protein |
| M. ulcerans Agy99 | MUL_2521 | - | 0.0 | 99.34% (1057) | ATP-dependent DNA helicase |
| M. vanbaalenii PYR-1 | Mvan_1801 | - | 0.0 | 63.91% (1039) | UvrD/REP helicase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4666|M.gilvum_PYR-GCK -------------MSAPQTELTTDALGRRDLRGTVRVLGGPGTGKSSLLV
Mvan_1801|M.vanbaalenii_PYR-1 -------------MSAPHTELSPEALSRRDVRGTVRVLGGPGTGKSSLLV
MSMEG_1941|M.smegmatis_MC2_155 ----------MTTRPAESAPQTASTLLEPGSNGVVRLLGGPGTGKSSLLV
MMAR_1358|M.marinum_M --------------MSLSWGAEARELLTPGSRGLVRVLGGPGTGKSALLV
MUL_2521|M.ulcerans_Agy99 --------------MSLSWGAEARELLTPGSRGLVRVLGGPGTGKSALLV
Mb3227c|M.bovis_AF2122/97 --------------MSHIWGVEAGAALAPGLRGPVLVLGGPGTGKSTLLV
Rv3202c|M.tuberculosis_H37Rv --------------MSHIWGVEAGAALAPGLRGPVLVLGGPGTGKSTLLV
MAV_4148|M.avium_104 --------------MSFTWDAQAGAVLAPGAHGTVRVLGGPGTGKSSLLV
MAB_3516c|M.abscessus_ATCC_199 --------MSAPPPSSRYWDGAAACLLDPDRTGRFVVVGGSGTGKTSLLV
TH_3022|M.thermoresistible__bu MTPITRANSWPDGRIPVLLSAHAEDLLRADARALLDYLDREPAAAVXXXX
MLBr_00153|M.leprae_Br4923 -------------------MSVHTTDAKPDSEVDRLLDGLNPQQRQAVVH
. .
Mflv_4666|M.gilvum_PYR-GCK DTAVAHIAAGCDPESVLLLTGSARLSVQVRASITSA---LLGAG----GR
Mvan_1801|M.vanbaalenii_PYR-1 DTAAAHIAAGCDPESVLLLTGSSRLSAQARAAITTA---LLGAG----AR
MSMEG_1941|M.smegmatis_MC2_155 DTAVQHILAGADPESVLLLTGSARLRTAARAAITAR---LLGAG----TV
MMAR_1358|M.marinum_M QAAIAHIAAGADPESVLLLTGSGRMGMWARSSLTTA---LLRSHTTGTGR
MUL_2521|M.ulcerans_Agy99 QAAIAHIAAGADPESVLLLTGSGRMGMRARSSLTTA---LLRSHTTGTGR
Mb3227c|M.bovis_AF2122/97 EAAVAHIGAGTDPESVLLLTGSGRMGMRARSALTTA---LLRSRTNGPCR
Rv3202c|M.tuberculosis_H37Rv EAAVAHIGAGTDPESVLLLTGSGRMGMRARSALTTA---LLRSRTNGPCR
MAV_4148|M.avium_104 DAAVAQIEAGVNPESVLLLTGSGRLPMAERSALTTA---LLRSAGAGP--
MAB_3516c|M.abscessus_ATCC_199 DIVAAHTAAGVNPASVLVLTGSNRASAELRNRISAA---VFERCAG----
TH_3022|M.thermoresistible__bu RAVIRAADRTELADGLRAVADGAEHRLVARSDHSTAPRLAFVFPGQGSQW
MLBr_00153|M.leprae_Br4923 EGSPLLIVAGAGSGKTTVLARRIAYLIAARSVGVSQ---ILAITFTNKAA
. :: * : :
Mflv_4666|M.gilvum_PYR-GCK AAVREPLVRTVHSYAFGVLRLAAQRNGS---PPPRLITSAE---------
Mvan_1801|M.vanbaalenii_PYR-1 SAVREPLVRTVHSYAFAVLRLAAQRNGS---PPPRLITSAE---------
MSMEG_1941|M.smegmatis_MC2_155 GVVREPLVRTVHSYAFAVLRLAAQRNGD---PPPRLITSAE---------
MMAR_1358|M.marinum_M AAVREPLVRSVHSYAYAVLRRAAERTGD---APPRLLTSAE---------
MUL_2521|M.ulcerans_Agy99 AAVREPLVRSVHSYAYAVLRRAAERTGD---APPRLLTSAE---------
Mb3227c|M.bovis_AF2122/97 AAIREPVVRTVHSYAYAVLRKAAQRAGD---ALPRLLTSAE---------
Rv3202c|M.tuberculosis_H37Rv AAIREPVVRTVHSYAYAVLRKAAQRAGD---ALPRLLTSAE---------
MAV_4148|M.avium_104 -AVREPLVRTVHGYAYAVLRRAAERAGE---APPRLVTSAE---------
MAB_3516c|M.abscessus_ATCC_199 VAIREPMVRTVHSYAFAVLAAHAACQGN---PPPRLITAAE---------
TH_3022|M.thermoresistible__bu PGMGAAAYRQFAEYRAGVDACAAAFTAAGAPAPLRYLTTPDDPESFCETE
MLBr_00153|M.leprae_Br4923 AEMRERVARLVGDHTGPSMWVSTFHSTC-----VRILRNQA---------
: * . : : * :
Mflv_4666|M.gilvum_PYR-GCK -----------------QDGIIRELLAG-DVEDGPASPVRWPEQLRPALS
Mvan_1801|M.vanbaalenii_PYR-1 -----------------QDGIIRELLAG-DVEDGDASPVRWPERLRPALS
MSMEG_1941|M.smegmatis_MC2_155 -----------------QDGIIRELLAG-DLEDGHRSPVGWPEQLWPALT
MMAR_1358|M.marinum_M -----------------QDAIIRELLAG-DLEDGPSARSAWPRHLLPALT
MUL_2521|M.ulcerans_Agy99 -----------------QDAIIRELLAG-DLEDGPSAGSAWPRHLLPALT
Mb3227c|M.bovis_AF2122/97 -----------------QDAIIRELLAG-DAEDGPAATTTWPAHLRPALT
Rv3202c|M.tuberculosis_H37Rv -----------------QDAIIRELLAG-DAEDGPAATTTWPAHLRPALT
MAV_4148|M.avium_104 -----------------QDAIIRELLAG-DLADGPRAATAWPAALRPALS
MAB_3516c|M.abscessus_ATCC_199 -----------------QDSIVRELLCG-NAEDNSGS---WPASLRPALA
TH_3022|M.thermoresistible__bu VEGAQFTHAVALARMWRHHGVLPDITVGHSLGEVGAAYIAGAITLADAVS
MLBr_00153|M.leprae_Br4923 -----------------------SLIGG--LNSNFSIYDVDDSRSLLQMI
.: * . :
Mflv_4666|M.gilvum_PYR-GCK TVGFATELRDLMAR---CSERGIDPVALQRIGRHA---------GRPEWQ
Mvan_1801|M.vanbaalenii_PYR-1 TVGFATELRDLMAR---CSERGVDPLALQRIGRAA---------GRPEWQ
MSMEG_1941|M.smegmatis_MC2_155 TAGFATELRDLMAR---CTERGVDPIALQRLGRTA---------KRPEWL
MMAR_1358|M.marinum_M TAGFATELRNLLAR---CAERGVDPMELERLGRRS---------GRPEWA
MUL_2521|M.ulcerans_Agy99 TAGFATELRNLLAR---CAERGVDPMELERLGRRS---------GRPEWA
Mb3227c|M.bovis_AF2122/97 TAGFATELRNLLAR---CAERGLDPLELQQLGRRR---------GRPEWI
Rv3202c|M.tuberculosis_H37Rv TAGFATELRNLLAR---CAERGLDPLELQQLGRRR---------GRPEWI
MAV_4148|M.avium_104 TAGFATELRNLLAR---CAERGVDPQALERLGRRC---------RRPEWV
MAB_3516c|M.abscessus_ATCC_199 TAGFATGVRDLMAR---CTERGVDARELRAIGRRH---------NRPEWI
TH_3022|M.thermoresistible__bu VVIARAGVVDRLPGRYAVAVLGVDADAARDVIASTPGWLELSVVNAPSSV
MLBr_00153|M.leprae_Br4923 GQDMGLDIKRYSPR---LMANAISNLKNELIDAES--------------A
: . .:. . :
Mflv_4666|M.gilvum_PYR-GCK AAG-----------------RFAQAYEQ----------------------
Mvan_1801|M.vanbaalenii_PYR-1 AAG-----------------RFAQAYEQ----------------------
MSMEG_1941|M.smegmatis_MC2_155 AAG-----------------RFAQAYEQ----------------------
MMAR_1358|M.marinum_M AAG-----------------RFARQYEQ----------------------
MUL_2521|M.ulcerans_Agy99 AAG-----------------RFARQYEQ----------------------
Mb3227c|M.bovis_AF2122/97 AAG-----------------QFAQRYEQ----------------------
Rv3202c|M.tuberculosis_H37Rv AAG-----------------QFAQRYEQ----------------------
MAV_4148|M.avium_104 AAG-----------------QFARQYEQ----------------------
MAB_3516c|M.abscessus_ATCC_199 AVA-----------------GLAREYEE----------------------
TH_3022|M.thermoresistible__bu AVSGDRDAVSAAVARVREQGRFAREITVGFPVHTSILEPLRDDLLRNLPQ
MLBr_00153|M.leprae_Br4923 VAN------------------LSSDTDD----------------------
.. ::
Mflv_4666|M.gilvum_PYR-GCK -------IMLLRSAVGMAAPQAT----------------VPALGAAELVG
Mvan_1801|M.vanbaalenii_PYR-1 -------VMLLRAAVGMAAPQAT----------------VPALGAAELVG
MSMEG_1941|M.smegmatis_MC2_155 -------IMLLRSAVGMAAPQAT----------------VPALGAAELVG
MMAR_1358|M.marinum_M -------VMLLRAAVGTATPQAT----------------APALGAAELVG
MUL_2521|M.ulcerans_Agy99 -------VMLLRAAVGTATPQAT----------------APALGVAELVG
Mb3227c|M.bovis_AF2122/97 -------VMLLRGAVGLAAPQAT----------------APALSAAELVG
Rv3202c|M.tuberculosis_H37Rv -------VMLLRGAVGLAAPQAT----------------APALSAAELVG
MAV_4148|M.avium_104 -------VMLLRAAVGTAAPEAT----------------TPALGAAELVG
MAB_3516c|M.abscessus_ATCC_199 -------VMLLRSAVGMAAPQAT----------------VPALGAAELVG
TH_3022|M.thermoresistible__bu AEFADSPVQFIGAATGDVVPAGTGFGPYWYGNLRHLVRFDRAFQTALRCG
MLBr_00153|M.leprae_Br4923 ------LARTVATVYGEYQRRLR---------------TANALDFDDLIG
: . * *: *
Mflv_4666|M.gilvum_PYR-GCK A-ALEAFAMDADLLSAE---RSRVQLLLVDDAQHLDPQAARLVEVLAAG-
Mvan_1801|M.vanbaalenii_PYR-1 A-ALEAFATDADLLAAE---RARVQLLLVDDAQHLDPQAARLVEVLATG-
MSMEG_1941|M.smegmatis_MC2_155 A-ALEALGADDELLDTE---RNRIKLLLVDDAQHLDPQAARLVRALAAG-
MMAR_1358|M.marinum_M S-ALEAFASDPELLAAE---RARLRFLLVDDAQQLDPQAARLVEVLAAG-
MUL_2521|M.ulcerans_Agy99 S-ALEAFASDPELLAAE---RARLRFLLVDDAQQLDPQAARLVEVLAAG-
Mb3227c|M.bovis_AF2122/97 A-ALEAFAVDPELLAAE---RARVRTLLVDDAQQLDPQAARLVRMLAAG-
Rv3202c|M.tuberculosis_H37Rv A-ALEAFAVDPELLAAE---RARVRTLLVDDAQQLDPQAARLVRMLAAG-
MAV_4148|M.avium_104 A-ALEAFAVDAELLAAE---RGRIRVLLVDDAQQLDPQAARLVRVLAAG-
MAB_3516c|M.abscessus_ATCC_199 S-ALETFAVEPGMLAAE---RDRIELLLVDDAQHLDPQAALLVRLLAER-
TH_3022|M.thermoresistible__bu ARTFVELSAHPSLLFAMSELLGDTPATLLGSTRRDEPIAETFTANLAAAA
MLBr_00153|M.leprae_Br4923 E-TVGILQAFPQIAEHY---RRRFRHVLVDEYQDTNHAQYVLVRELVGH-
:. : : *:.. : : :. *.
Mflv_4666|M.gilvum_PYR-GCK -------------AELTVIAGDPHQ-----------------TVFGYRGA
Mvan_1801|M.vanbaalenii_PYR-1 -------------AELAVIAGDPHQ-----------------TVFGYRGA
MSMEG_1941|M.smegmatis_MC2_155 -------------TGLTVIAGDPDQ-----------------SVFGYRGA
MMAR_1358|M.marinum_M -------------AEFALIAGDPNQ-----------------AVFGFRGG
MUL_2521|M.ulcerans_Agy99 -------------AEFALIAGDPNQ-----------------AVFGFRGG
Mb3227c|M.bovis_AF2122/97 -------------TELALIAGDPNQ-----------------AVFGFRGG
Rv3202c|M.tuberculosis_H37Rv -------------TELALIAGDPNQ-----------------AVFGFRGG
MAV_4148|M.avium_104 -------------ADLALIAGDPNQ-----------------AVFGFRGG
MAB_3516c|M.abscessus_ATCC_199 -------------AGFCVIAGDPNQ-----------------TVFGFRGA
TH_3022|M.thermoresistible__bu VSDPGYDWRAVTPAGPDRLTGFPNAPMRAIPMWATAAPRRIGRAGGVRGE
MLBr_00153|M.leprae_Br4923 -----------------GARNSPDD-------------------------
. *.
Mflv_4666|M.gilvum_PYR-GCK DPALLRGD---------GPALILNRSHRCAAPLADAIAAITRR-------
Mvan_1801|M.vanbaalenii_PYR-1 DPALLRGE---------GPALTLTRSHRCANPVADAIGAVGRR-------
MSMEG_1941|M.smegmatis_MC2_155 DPVLLRDDT--------HPAITLTQSYRCAPEIASAITGLGQR-------
MMAR_1358|M.marinum_M EPAGLLGG--PLDGG---PAVTLTMSHRCAPAVARAVSGIARR-------
MUL_2521|M.ulcerans_Agy99 EPAGLLGG--PLDGG---PAVTLTMSHRCAPAVARAVSGIARR-------
Mb3227c|M.bovis_AF2122/97 EPTGLLADDPPPAGGAPIPSVTLTVSHRCAPAVARAVTGIARR-------
Rv3202c|M.tuberculosis_H37Rv EPTGLLADDPPPAGGAPIPSVTLTVSHRCAPAVARAVTGIARR-------
MAV_4148|M.avium_104 DPGSLLDG--------AAPAVTLTTSHRCAPAVARAVSGVAGR-------
MAB_3516c|M.abscessus_ATCC_199 DTQLLQVS-----ADSRTTMIELDGSHRCAAPIAELANSVARR-------
TH_3022|M.thermoresistible__bu EAPGLRIA-----AEVWEPVAAQPGPASAATPVPVALLELGDTGRLGGWL
MLBr_00153|M.leprae_Br4923 --------------------------------------------------
Mflv_4666|M.gilvum_PYR-GCK --LPGADASREFTG-RAEQGTLAVR---IAASPHAESALIADALRRAHLV
Mvan_1801|M.vanbaalenii_PYR-1 --LPGAEATREFTG-SDAPGSVTVQ---IAASPHAESALIADALRRAHLV
MSMEG_1941|M.smegmatis_MC2_155 --LPGVSDTRHWTGNPQREGTVTVR---LAASTHAEGTMIADALRRAHLV
MMAR_1358|M.marinum_M --LPGGSAGRHIDGTGTEDGSVTVR---LAATAHAEAAAIADALRRAHLV
MUL_2521|M.ulcerans_Agy99 --LPGGSAGRHIDGTGTEDGSVTVR---LAATAHAEAAAIADALRRAHLV
Mb3227c|M.bovis_AF2122/97 --LPGRSVGRRIEGTGTEVGSVTVR---LAGSAHAEAAMIADALRRAHLI
Rv3202c|M.tuberculosis_H37Rv --LPGRSVGRRIEGTGTEVGSVTVR---LAGSAHAEAAMIADALRRAHLI
MAV_4148|M.avium_104 --LPGSSAGRRIEGAGPGEGSVAVR---LAASAHAEAAAIADALRRAHLV
MAB_3516c|M.abscessus_ATCC_199 --LPGSSPARVIHGVENGPAAVRLA---AVPTETAEASLVVDLLRRSHLI
TH_3022|M.thermoresistible__bu RELLGNRPDVVLVGPEAAEVAVVAAPESDTAAPEAGVAAITELVRAGGLR
MLBr_00153|M.leprae_Br4923 -------------------------------MPPGELCVVGDADQSIYAF
. : : :
Mflv_4666|M.gilvum_PYR-GCK D----------------GVPWDRMAVIVRSVPRTGASLGRA--------L
Mvan_1801|M.vanbaalenii_PYR-1 D----------------GVPWSQMAVIVRSVPRMGAALGRA--------L
MSMEG_1941|M.smegmatis_MC2_155 D----------------GIPWSQMAVIVRSVPRVGTALARA--------L
MMAR_1358|M.marinum_M D----------------GVPWSQMAVIVRSVPRVAARLPRA--------L
MUL_2521|M.ulcerans_Agy99 D----------------GVPWSQMAVIVRSVPRVAARLPRA--------L
Mb3227c|M.bovis_AF2122/97 D----------------GVPWSQMAVIVRSVPR-AVRLPRA--------L
Rv3202c|M.tuberculosis_H37Rv D----------------GVPWSQMAVIVRSVPR-AVRLPRA--------L
MAV_4148|M.avium_104 D----------------GVPWSQMAVIVRSVPRAGARLPRA--------L
MAB_3516c|M.abscessus_ATCC_199 D----------------GVPWSRMAVIVRSVPRSGAALCRA--------L
TH_3022|M.thermoresistible__bu YPAAPGPHCRDVWLVTVGAEQVHPDDPVAPVPAAVAAMHRS--------L
MLBr_00153|M.leprae_Br4923 R----------------GSTISNIEDFERDYPDTTTILLEQNYRSTQNIL
* . * . : . *
Mflv_4666|M.gilvum_PYR-GCK AAAG--VPVEDPHPDVPLA------NQPAVQALLT--VLEATAEK-LDGE
Mvan_1801|M.vanbaalenii_PYR-1 TAAG--VPLDLPQPEVPLA------EQPAVRALLT--VLEATADG-LDGE
MSMEG_1941|M.smegmatis_MC2_155 TAAG--VPVQDNGTDVPVG------RQPAAAALLT--VLDVTATGHLDAD
MMAR_1358|M.marinum_M AAAG--VPVSIPPIGGSLA------EEPAVGALLT--VLAATAEG-LNAD
MUL_2521|M.ulcerans_Agy99 AAAG--VPVSIPPIGGSLA------EEPAVGALLT--VLAATAEG-LNAD
Mb3227c|M.bovis_AF2122/97 AAAG--VPVAPPAVGGPLS------AEPAVRALLT--VLEATADG-LDGD
Rv3202c|M.tuberculosis_H37Rv AAAG--VPVAPPAVGGPLS------AEPAVRALLT--VLEATADG-LDGD
MAV_4148|M.avium_104 AAAG--VPVTAPAASGPLA------EQPAVRALLT--VLLATADG-LDGQ
MAB_3516c|M.abscessus_ATCC_199 QSAG--VPVHAESYDGPVA------SVPAVHALLL--AVSAAQGG-VTHE
TH_3022|M.thermoresistible__bu GLENPQIPFHHLDLEQGVGSDTARDTDPAVAALLMDAVLSATGGGGLAIR
MLBr_00153|M.leprae_Br4923 SAANS---------------------------------------------
.
Mflv_4666|M.gilvum_PYR-GCK RALA---------------------------LVTGPIGRVDPVSLRQLRR
Mvan_1801|M.vanbaalenii_PYR-1 RALA---------------------------LVTGPIGRVDPISLRQLRR
MSMEG_1941|M.smegmatis_MC2_155 SAVA---------------------------LLTGPIGRVDPVTLRQLRR
MMAR_1358|M.marinum_M QALA---------------------------LITGPIGRVDPVTLRQLRR
MUL_2521|M.ulcerans_Agy99 QALA---------------------------LITGPIGRVDPVRLRQLRR
Mb3227c|M.bovis_AF2122/97 QALL---------------------------LLTGPIGGVDPVSLRQLRR
Rv3202c|M.tuberculosis_H37Rv QALL---------------------------LLTGPIGGVDPVSLRQLRR
MAV_4148|M.avium_104 RALA---------------------------LLTGPIGRVDPVSLRQLRR
MAB_3516c|M.abscessus_ATCC_199 DAVT---------------------------LATGPLGRVDPVALRRLRR
TH_3022|M.thermoresistible__bu TTGAGAVLYRRGLRDVPAPPPLDRPGLLDEVVITGGAGAIGLHYARQLAR
MLBr_00153|M.leprae_Br4923 -------------------------------VIARNFGRRDKRLWTDAGK
: : * . :
Mflv_4666|M.gilvum_PYR-GCK -TLRRG-VTAPD-RGFGELLVEALER---------DVAALPDEHARALRR
Mvan_1801|M.vanbaalenii_PYR-1 -ALRRA-APESP-GGFSDLLVDALQR---------DTPALADGQARALRR
MSMEG_1941|M.smegmatis_MC2_155 -ALRRADGSQPP-RDFGDLLVDAIER---------EPKGLSAEHARTLRR
MMAR_1358|M.marinum_M -TLRRAVAGRSP-EDFGDLLVATLSEDGRPAVGSAGSNQPPGPQFGPLRR
MUL_2521|M.ulcerans_Agy99 -TLRRAVAGRSP-EDFGDLLVATLSEDGRPAVGSAGSNQPPGPQFGPLRR
Mb3227c|M.bovis_AF2122/97 -TLQRARPGQTS-RKFGDLLVEVLG----------GDAPPSGPGSRALRR
Rv3202c|M.tuberculosis_H37Rv -TLQRARPGQTS-RKFGDLLVEVLG----------GDAPPSGPGSRALRR
MAV_4148|M.avium_104 -NLQRANAGRPP-GDFAELLVEALT----------GTAPPPGALFRALRR
MAB_3516c|M.abscessus_ATCC_199 -QLLRAEEAAGGERGSAELLRAVLVEADET-----HLAALTDIQAAPLRR
TH_3022|M.thermoresistible__bu RGAKRIVLLSRRPVDPAELAALAAPTGAEVLS---VSCDLTDPDAVXXXX
MLBr_00153|M.leprae_Br4923 ----------------GELIVGYVSD------------NEHDEAKFIADE
.:*
Mflv_4666|M.gilvum_PYR-GCK LRAVLTSARRSAEQG----GDPRQTLWQAWNRSGLQKRWLAAAERGGPAA
Mvan_1801|M.vanbaalenii_PYR-1 VCAVLTAARRSAREG----SDPRHTLWQAWHRSGLQKRWLAASERGGPAG
MSMEG_1941|M.smegmatis_MC2_155 LRAVLTAARRSDASG----ADPRYTLWQAWHASGLQRRWLAASERGGSVG
MMAR_1358|M.marinum_M VRAVLAAATRCHRAG----QDPRYILWAAWHRSGLQNRWLAAIDRGGPAG
MUL_2521|M.ulcerans_Agy99 VRAVLAAATRCHRAG----QDPRYILWAAWHRSGLQNRWLAAIDRGGPAG
Mb3227c|M.bovis_AF2122/97 VRAVLTAAARCHRSGSLGGQDPRHTLWAAWQRSGLQRRWLAASEHGGAAA
Rv3202c|M.tuberculosis_H37Rv VRAVLTAAARCHRSGSLGGQDPRHTLWAAWQRSGLQRRWLAASEHGGAAA
MAV_4148|M.avium_104 VRAVLDAAGRCHRDG----QDPRYILWAAWHRSGLQRRWLSVSERGGPAA
MAB_3516c|M.abscessus_ATCC_199 VRAVIGAAREATASG----ASVLDVLWAAWTRSGLQRRWDGLSQRGGPLG
TH_3022|M.thermoresistible__bu VRAVLTAAERAHRHG----GDPREVLWQAWHRSGLQRRWLAASERGGVAG
MLBr_00153|M.leprae_Br4923 IDALVGGGE-------------------------ITYDDVAVLYRANNLS
: *:: .. : . :.. .
Mflv_4666|M.gilvum_PYR-GCK AQAERDLDAVTALFDVAEQYVERTAGASLRGLIDHITGLSLPPARGD-AR
Mvan_1801|M.vanbaalenii_PYR-1 AQADRDLDAVTAMFDVAEQYVARTAGASLRGLVDHITALALPPARRD-EA
MSMEG_1941|M.smegmatis_MC2_155 AQADRDLDAVTTLFDVADQYVNRTAGASLRGLVDHVTRLGAAVARTEPET
MMAR_1358|M.marinum_M VQATRNLEAVTALFDITDQYVSRTSGASLSGLLEHVAALQLPRVSEEPVA
MUL_2521|M.ulcerans_Agy99 VQATRNLEAVTALFDITDQYVSRTSGASLSGLLEHVAALQLPRVSEEPVA
Mb3227c|M.bovis_AF2122/97 VQATRDLETVTALFDITDHYVSRTSGASLRGLVEHVTALQLPVVRPEPAA
Rv3202c|M.tuberculosis_H37Rv VQATRDLETVTALFDITDHYVSRTSGASLRGLVEHVTALQLPVVRPEPAA
MAV_4148|M.avium_104 AQAGRDLDSVTALFDITDDYVSRTSGASLRGLVEHVAALQLPGAGPVPVA
MAB_3516c|M.abscessus_ATCC_199 AQADRDLDAVSSLFDLASEHVARTPGIGVTGLIDHIRSLALVGQRTT-RL
TH_3022|M.thermoresistible__bu VQADRDLDAVTAFFDAAEQYVARTAGATLRGLIDHLTTLGPAAPARDQSA
MLBr_00153|M.leprae_Br4923 RSLEEVFIPTGIPYKVVGGFCFYES-KEIRDLIAYLRVLDNPGDAVSMRR
. . : .. :. . . . : .*: :: *
Mflv_4666|M.gilvum_PYR-GCK SGDAVALISAHAALSGEWDFVVLAGLQEGLWPNVSPRGGVLATQHLVDVI
Mvan_1801|M.vanbaalenii_PYR-1 APDAVALLSAHSALGHEWEFVVLAGVQEGLWPNVSPRGGVLATQQLVDVI
MSMEG_1941|M.smegmatis_MC2_155 AAEAVAVLSVHGALAGEWDFVVIAGVQEGLWPNMIPRGGVLGTQHLVDVL
MMAR_1358|M.marinum_M QNEQVRVLSAHAALGHEWDLVVIAGLQDGLWPNTIPRGGVLATQRLLDEL
MUL_2521|M.ulcerans_Agy99 QNEQVGVLSAHAALGHEWDLVVIAGLQDGSWPNTIPRGGVLATQRLLDEL
Mb3227c|M.bovis_AF2122/97 PTEQVMVLSAHAALGHEWDLVVIAGLQDGLWPNTVPRGGVLGTQRLLDEL
Rv3202c|M.tuberculosis_H37Rv PTEQVMVLSAHAALGHEWDLVVIAGLQDGLWPNTVPRGGVLGTQRLLDEL
MAV_4148|M.avium_104 TAEQVSVLSAHAALGREWDFVVIAGLQDGLWPNTVPRGGVLGTQRLLDVL
MAB_3516c|M.abscessus_ATCC_199 EPDAVAIVSAHAAVGREWDVVAIPGVQEGLWPNTAVRGGVLRTQELMDVL
TH_3022|M.thermoresistible__bu RRDAVAVLSAHAALDREWDLVVIAGLQDGLWPNTVPRGGVLATQQLVDVL
MLBr_00153|M.leprae_Br4923 ILN-----TPRRGIGDRAEACVSVYAEN-------------TGTSFADAL
: : : .: . : . :: : * :
Mflv_4666|M.gilvum_PYR-GCK DGVAAPGQR-LSSRAPLLAEERRLLIAAMGRARSRVLVTAVDSDS---GD
Mvan_1801|M.vanbaalenii_PYR-1 DGVCAPGQHTLSSRAPLLAEEWRLLIAAMGRARSRLLVTAVDSDC---GD
MSMEG_1941|M.smegmatis_MC2_155 DGVADMTDRTVSTRAPLVAEERRLLMAAMGRARTRVMITAVDSDT---GD
MMAR_1358|M.marinum_M DGVSG----NASARAPLLAEERRLLLAAMGRARRQLLVTAVDGDTSGGGQ
MUL_2521|M.ulcerans_Agy99 DGVSG----NASARAPLLAEERRLLLAAMGRARRQLLVTAVDGDTSGGGQ
Mb3227c|M.bovis_AF2122/97 DGVTK----DASMRAPLLAEERRLLVTAMGRARRRLLVTAVDSDAGGGGH
Rv3202c|M.tuberculosis_H37Rv DGVTK----DASMRAPLLAEERRLLVTAMGRARRRLLVTAVDSDAGGGGH
MAV_4148|M.avium_104 DGVSA----DASVRAPLLAEERRLLVAAMGRARQRLLVTAVDSDTDGSDH
MAB_3516c|M.abscessus_ATCC_199 AGIEH--AAHVDGSAVALAEERRLLLLAVGRAARRVLITAVENENADMGG
TH_3022|M.thermoresistible__bu DGVADGSDPVVSRRAPLLAEERRLLIAAMGRARSRLLVTAVDSDD---GD
MLBr_00153|M.leprae_Br4923 QAVAEG-------KVPMLN-TRSVKAIAGFVALLDDLRCRVDDDLGELVE
.: . : : * * : *:.:
Mflv_4666|M.gilvum_PYR-GCK EAALPSPFCHELAAMAT-EPVPEPALPIRAPRVLSPAAVVGRLRSVVCAG
Mvan_1801|M.vanbaalenii_PYR-1 DAMLPSSFCHELAALAT-EPQSQPAPPVRAPRVLAPSALVGRLRSVVCAA
MSMEG_1941|M.smegmatis_MC2_155 ESLLPSPFCAEISAWAT-EPVAEP--PLVAPRVLAPSALVGRLRAVVCAP
MMAR_1358|M.marinum_M QAALPSEFFFEIAQWANGDSQAVAAPPVSAPRVLSAAAVVGRLRGVVCAP
MUL_2521|M.ulcerans_Agy99 QAALPSEFFFEIAQWANGDSQAVAAPPVSAPRVLSAAAVVGRLRGVVCAP
Mb3227c|M.bovis_AF2122/97 EAVLPSAFFFEIAQWADGDGEPVAMQPVSAPRVLSAAAVVGRLRAVVCAP
Rv3202c|M.tuberculosis_H37Rv EAVLPSAFFFEIAQWADGDGEPVAMQPVSAPRVLSAAAVVGRLRVVVCAP
MAV_4148|M.avium_104 EAALPSPFCYEIAQWAGEDVETAALQPVSAPRVLSAAALVGRLRGVVCAP
MAB_3516c|M.abscessus_ATCC_199 GPAMASRFLTELMAAHPEWVISEYRPGAAQSRVLTAANLVGELRAVVTAP
TH_3022|M.thermoresistible__bu ESLLPSPFCAELAALAT-EPEAATPAPLPAPRVLTAAALVGRLRSVVCAA
MLBr_00153|M.leprae_Br4923 SVLERSGYLRELESSTD-------------PQELARLDNLNELVSFAHEF
* : *: .: *: :..* ..
Mflv_4666|M.gilvum_PYR-GCK SDEVSEDERVCAAAQLARLATAGVHGADPSSWYGARELSSDEPLWDGDDH
Mvan_1801|M.vanbaalenii_PYR-1 PGAVDDVERDCAAAQLARLAEAGVHGADPASWYGSRELSSAEPLWEDGEQ
MSMEG_1941|M.smegmatis_MC2_155 DGAVDDDARACAAAQLARLAAAGVPGADPSQWHAMTSLTTEEPLWSEPGH
MMAR_1358|M.marinum_M DGAVDDAARQCAATQLARLAKAGVAGADPAGWHGLIPVSTTAALY-GAGD
MUL_2521|M.ulcerans_Agy99 DGAVDDAARQCAATQLARLAKAGVAGADPAGWHGLIPVSTTAALY-GAGD
Mb3227c|M.bovis_AF2122/97 ACAVDDADRDCAATQLARLAKAGVPGADPSEWHGLAPVSTSDPLC-DSDD
Rv3202c|M.tuberculosis_H37Rv ACAVDDADRDCAATQLARLAKAGVPGADPSEWHGLAPVSTSDPLC-DSDD
MAV_4148|M.avium_104 DGAVDELDRRCAATQLARLAQAGVPGADPASWHGLIPVSTAEPLR-GGGD
MAB_3516c|M.abscessus_ATCC_199 VEAVTDARRRAAARQLARLAAAGVPGADPESWYGLGDVSDERPLWLAEDG
TH_3022|M.thermoresistible__bu PDTVDDEVRAGAATQLARLAAAGVPGADPAQWYAMTPLSTGEPLWDGPGQ
MLBr_00153|M.leprae_Br4923 STEQANAAALAKSLHTPEDEDVPDTGALAAFLEKVSLMSDTDQIPENNSG
: : : .. . ** . :: :
Mflv_4666|M.gilvum_PYR-GCK VVTLSPSTLQMLADCPLRWLLERHGGARGRDVRSTLGSLVHALVSESGTA
Mvan_1801|M.vanbaalenii_PYR-1 VVTLSPSTLQMLSDCPLRWLLERHGGSRGRDVRSTLGSLVHALVSESGRT
MSMEG_1941|M.smegmatis_MC2_155 VVTLSPSTLQMLTDCPLRWLLERHGGDDGRDVRSTVGSLVHALVSEPGKT
MMAR_1358|M.marinum_M VVTLTPSTLQTLNDCPLRWLAERHGGTNPRDLRATIGSVLHALIAEPGAS
MUL_2521|M.ulcerans_Agy99 VVTLTPSTLQTLNDCPLRWLAERHGGTNPRDLRATIGSVLHALIAEPGAS
Mb3227c|M.bovis_AF2122/97 LVTLTPSTLQALNDCPLRWLAERHGGTNTRELPSAVGSVLHALFAEPGRS
Rv3202c|M.tuberculosis_H37Rv LVTLTPSTLQALNDCPLRWLAERHGGTNTRELPSAVGSVLHALFAEPGRS
MAV_4148|M.avium_104 VVTLTPSTMQTLTDCPLRWLAERHGGTDPRDLRSAIGSVVHALIAQPHRS
MAB_3516c|M.abscessus_ATCC_199 PVRVSPSNVETLMACPLRWMLERHGGTDLTDPRRALGTLVHELVGVHAED
TH_3022|M.thermoresistible__bu SVTLSPSTLQTLVDCPLRWLLERHGGTDGRDVRSTVGSLVHALAAGRYRT
MLBr_00153|M.leprae_Br4923 VVTLMTLHAAKGLEFPVVFVTGWEDG--MLPHMRTLG-DPTELSEERRLA
* : . *: :: ..* ::* *
Mflv_4666|M.gilvum_PYR-GCK ESVLLDELDKVWGKLPFDAQWHSDNERIRHLEMLATFLKWRSDTRGELTE
Mvan_1801|M.vanbaalenii_PYR-1 ESQLLNGLEKVWEELPFDAQWYSDNERVRHLEMLSTFLRWREGTRGELTE
MSMEG_1941|M.smegmatis_MC2_155 ESQLVNELEKVWDDLPYDAKWYSDNELARHRAMLETFTRWREDTRRQLTE
MMAR_1358|M.marinum_M EEQLLAELARVWKLLPFEADWFSSNELARHRAMIQAFVEWRGQTRSELTE
MUL_2521|M.ulcerans_Agy99 EEQLLAELARVWKLLPFEADWFSSNELARHRAMIQAFVEWRGQTRSELTE
Mb3227c|M.bovis_AF2122/97 ESQLLAELDRVWGHLPFGAQWYSANELARHRAMIQAFVQWRAQSRSELTE
Rv3202c|M.tuberculosis_H37Rv ESQLLAELDRVWGHLPFGAQWYSANELARHRAMIQAFVQWRAQSRSELTE
MAV_4148|M.avium_104 PAELVAELDRAWRHLPFAAQWHSDNELARHRAMLEAFAQWRANTRGALTE
MAB_3516c|M.abscessus_ATCC_199 SDAMCRALDKAWESMPFESQWYARNELRRHHELLEAFTTWRASTRGELTE
TH_3022|M.thermoresistible__bu EGQLLAELERVWDQLPFESRWYADNELSRHRAMLQTFMRWRERTRRELTE
MLBr_00153|M.leprae_Br4923 YVGITRARQRLYLSRAITRSSWG-------QPILNPESRFLREIPPELID
: : : . . :: . : * :
Mflv_4666|M.gilvum_PYR-GCK VGTEIDVDGVVAGGEGDGPGVRVRGRLDRLERDSEGRLVVVDVKTGKSPV
Mvan_1801|M.vanbaalenii_PYR-1 VGTEIEVDGQIAAPDGELPAVRLRGRLDRLERDSEGRLVVIDLKTGKSPV
MSMEG_1941|M.smegmatis_MC2_155 VATEIPVEGIVVEPGENTPGVRVRGRLDRLERDEAGRLVVVDLKTGKSPV
MMAR_1358|M.marinum_M VGVEIDIDGVLDAARDDGGAIRLRGRVDRLERDGAGRLVIVDIKTAKTPV
MUL_2521|M.ulcerans_Agy99 VGVEIDIDGVLDAARDDGGAIRLRGRVDRLERDGAGRLVILDIKTAKTPV
Mb3227c|M.bovis_AF2122/97 VGVEVDIDGALEDGSGQARKIRLRGRADRLERDPAGRLVIVDIKTGKTPV
Rv3202c|M.tuberculosis_H37Rv VGVEVDIDGALEDGSGQARKIRLRGRADRLERDPAGRLVIVDIKTGKTPV
MAV_4148|M.avium_104 VGVEVEIDGTLSTG--DGREVRLRGRVDRLERDAAGRLVIVDVKTGKTPV
MAB_3516c|M.abscessus_ATCC_199 VGREIGVDGVLSRAG--QPQVRLVGRIDRLERDAEGRPVVIDIKTGKSPA
TH_3022|M.thermoresistible__bu VAAEIAVDGVLVDGADTTPEIRVRGRLDRLERDADGRLVVVDLKTGKSPV
MLBr_00153|M.leprae_Br4923 WRRSILTDSYSTPASGASRFGRVR---PSSIRSGASKRALLVLAPG----
.: :. *: *. .: .:: : ..
Mflv_4666|M.gilvum_PYR-GCK SKDDAQAHAQLAMYQLAVAAGLIADG---DEPGGGRLVYLGKT-TGGRAT
Mvan_1801|M.vanbaalenii_PYR-1 SKDDAQSHAQLAMYQLAVAAGLLADG---DEPGGGRLVYLGKT-TGGGAT
MSMEG_1941|M.smegmatis_MC2_155 TKDDAQNHAQLAMYQLAVAAGLLDDG---DEPGGGKLVYLGKA-GAAGAT
MMAR_1358|M.marinum_M SKDDAQQNAQLAMYQLAVAEGMVEAG---AEPGGARLVYPGKS-AAAGAA
MUL_2521|M.ulcerans_Agy99 SKDDAQQNAQLAMYQLAVAEGMVEAG---AEPGGARLVYPGKS-AAAGAA
Mb3227c|M.bovis_AF2122/97 SKDDAQQHAQLAMYQLAVAEGLVRAG---DEPGGARLVYVGKS-GAAGVA
Rv3202c|M.tuberculosis_H37Rv SKDDAQQHAQLAMYQLAVAEGLVRAG---DEPGGARLVYVGKS-GAAGVA
MAV_4148|M.avium_104 SKDDAQQHAQLALYQLAVAHGLLGAAGGDAEPGGARLVYVGKA-AASGVV
MAB_3516c|M.abscessus_ATCC_199 TKDDAQQHAQLAAYQVAAAEGLIEGEP-AGAPGGGRLVYIAKPNLDDGAT
TH_3022|M.thermoresistible__bu TKNDAQRHAQLAMYQLAVAAGLLPAG---DIPGGGRLVYLGRP-TGGGAT
MLBr_00153|M.leprae_Br4923 ---DRVTHDKYGLGRVEEVSGVGESA--------ISLIDFGSS-------
* : : . :: . *: *: . .
Mflv_4666|M.gilvum_PYR-GCK ERHQDAVTPEVRELWEARVHEAAAATQGPSFVARVNDGCAHCPVRATCPA
Mvan_1801|M.vanbaalenii_PYR-1 ERHQDALTPDGRAEWDEQVHRAAAATQGPQFTARVNDGCAHCPVRAMCPA
MSMEG_1941|M.smegmatis_MC2_155 EREQDPLTPDKRAEWLETVGEAAAATAGPRFVARVNNGCANCPVRSSCPA
MMAR_1358|M.marinum_M QRDQDPLTPAARDQWRNLVRQAAEAAAGPHFIARRNDGCSHCPIRPSCPA
MUL_2521|M.ulcerans_Agy99 QRDQDPLTPAARDQWRNLVRQAAEAAAGPHFIARRNDGCSHCPIRPSCPA
Mb3227c|M.bovis_AF2122/97 ERKQDPLTPAARDEWRNLVRQLAAATAGPQFIARRNDGCTHCPLRPGCPA
Rv3202c|M.tuberculosis_H37Rv ERKQDPLTPAARDEWRNLVRQLAAATAGPQFIARRNDGCTHCPLRPGCPA
MAV_4148|M.avium_104 EREQDPLTAAAADQWREALRRAADATAGPQFIARRNDGCTHCPLRPCCPA
MAB_3516c|M.abscessus_ATCC_199 QRHQDPLTPAAQDAWRESIHNAAASTQGPIFVARVNDGCGHCPLRTCCPA
TH_3022|M.thermoresistible__bu EREQDPLTPETAAGWRDTVAQAADATRGPRFAARINDGCAHCPVRFSCPA
MLBr_00153|M.leprae_Br4923 --------------------------------GRIKLMHNHAPVTKL---
.* : :.*:
Mflv_4666|M.gilvum_PYR-GCK QNSRSQP---
Mvan_1801|M.vanbaalenii_PYR-1 QN-RSDT---
MSMEG_1941|M.smegmatis_MC2_155 QANGDRP---
MMAR_1358|M.marinum_M HTDRSPR---
MUL_2521|M.ulcerans_Agy99 HTDRSPR---
Mb3227c|M.bovis_AF2122/97 HVRGSAP---
Rv3202c|M.tuberculosis_H37Rv HVRGSAP---
MAV_4148|M.avium_104 HADGSGR---
MAB_3516c|M.abscessus_ATCC_199 QTDGQAVCQS
TH_3022|M.thermoresistible__bu QAAQAGSERP
MLBr_00153|M.leprae_Br4923 ----------