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APKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELA EGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSP LPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVA VVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSG HFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFD RAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADP GYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHRHLAVL DLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGAR CQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGF GETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRA ADQATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFA AKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQA PKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLDSRQFERYEGPT DPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDG LVAKLEDADERSHTAQKVDISRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2381c | mbtD | - | 100% (1004) | POLYKETIDE SYNTHETASE MBTD (POLYKETIDE SYNTHASE) |
| M. tuberculosis H37Rv | Rv2932 | ppsB | 7e-61 | 25.41% (1047) | phenolpthiocerol synthesis type-I polyketide synthase PPSB |
| M. tuberculosis H37Rv | Rv1661 | pks7 | 2e-56 | 33.02% (421) | polyketide synthase pks7 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2402c | mbtD | 0.0 | 100.00% (1004) | polyketide synthetase MBTD (polyketide synthase) |
| M. gilvum PYR-GCK | Mflv_2695 | - | 0.0 | 48.28% (990) | acyl transferase region |
| M. leprae Br4923 | MLBr_02356 | - | 4e-56 | 24.81% (1028) | polyketide synthase |
| M. abscessus ATCC 19977 | MAB_2119c | - | 1e-121 | 31.38% (1023) | putative polyketide synthase MbtD |
| M. marinum M | MMAR_3695 | mbtD | 1e-137 | 32.63% (1039) | polyketide synthase MbtD |
| M. avium 104 | MAV_2012 | - | 0.0 | 47.11% (1002) | MbtD protein |
| M. smegmatis MC2 155 | MSMEG_4512 | - | 0.0 | 49.36% (1017) | polyketide synthetase mbtd |
| M. thermoresistible (build 8) | TH_3022 | - | 0.0 | 53.36% (744) | PUTATIVE acyl transferase domain protein |
| M. ulcerans Agy99 | MUL_3638 | mbtD | 1e-133 | 32.24% (1039) | polyketide synthase MbtD |
| M. vanbaalenii PYR-1 | Mvan_3846 | - | 0.0 | 52.01% (994) | acyl transferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2381c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2402c|M.bovis_AF2122/97 --------------------------------------------------
TH_3022|M.thermoresistible__bu --------------------------------------------------
MSMEG_4512|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2695|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2012|M.avium_104 --------------------------------------------------
MMAR_3695|M.marinum_M --------------------------------------------------
MUL_3638|M.ulcerans_Agy99 --------------------------------------------------
MAB_2119c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02356|M.leprae_Br4923 MRTAFSRISGMTTQQRAALIEEFTKLSRIAVAEPIAVVGIGCRFPGDVTG
Rv2381c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2402c|M.bovis_AF2122/97 --------------------------------------------------
TH_3022|M.thermoresistible__bu --------------------------------------------------
MSMEG_4512|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2695|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2012|M.avium_104 --------------------------------------------------
MMAR_3695|M.marinum_M --------------------------------------------------
MUL_3638|M.ulcerans_Agy99 --------------------------------------------------
MAB_2119c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02356|M.leprae_Br4923 PDSFWDLLIDGRNAISRVPADRWDADAFYDPDPLTPGRMTTKWGGFVSDI
Rv2381c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2402c|M.bovis_AF2122/97 --------------------------------------------------
TH_3022|M.thermoresistible__bu --------------------------------------------------
MSMEG_4512|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2695|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2012|M.avium_104 --------------------------------------------------
MMAR_3695|M.marinum_M --------------------------------------------------
MUL_3638|M.ulcerans_Agy99 --------------------------------------------------
MAB_2119c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02356|M.leprae_Br4923 AGFDAAFFGITPREAAAMDPQQRILLEVAWEALENAGIPPDSLGNSRTGV
Rv2381c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2402c|M.bovis_AF2122/97 --------------------------------------------------
TH_3022|M.thermoresistible__bu --------------------------------------------------
MSMEG_4512|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2695|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2012|M.avium_104 --------------------------------------------------
MMAR_3695|M.marinum_M --------------------------------------------------
MUL_3638|M.ulcerans_Agy99 --------------------------------------------------
MAB_2119c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02356|M.leprae_Br4923 MIGVYFNEYQSMLASSLENVDAYSGTGNAHSITVGRISYLLGLRGPSLAV
Rv2381c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2402c|M.bovis_AF2122/97 --------------------------------------------------
TH_3022|M.thermoresistible__bu --------------------------------------------------
MSMEG_4512|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2695|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2012|M.avium_104 --------------------------------------------------
MMAR_3695|M.marinum_M --------------------------------------------------
MUL_3638|M.ulcerans_Agy99 --------------------------------------------------
MAB_2119c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02356|M.leprae_Br4923 DTACSSSLVAVHLACQSLRLRETDLVLAGGVSITLRPETQIAISAWGLLS
Rv2381c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2402c|M.bovis_AF2122/97 --------------------------------------------------
TH_3022|M.thermoresistible__bu --------------------------------------------------
MSMEG_4512|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2695|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2012|M.avium_104 --------------------------------------------------
MMAR_3695|M.marinum_M --------------------------------------------------
MUL_3638|M.ulcerans_Agy99 --------------------------------------------------
MAB_2119c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02356|M.leprae_Br4923 PHGRCAAFDAAADGFVRGEGAGVVVLKRLTDAVRDGDLVLAVVRGSAVNQ
Rv2381c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2402c|M.bovis_AF2122/97 --------------------------------------------------
TH_3022|M.thermoresistible__bu --------------------------------------------------
MSMEG_4512|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2695|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2012|M.avium_104 --------------------------------------------------
MMAR_3695|M.marinum_M --------------------------------------------------
MUL_3638|M.ulcerans_Agy99 --------------------------------------------------
MAB_2119c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02356|M.leprae_Br4923 DGRSNGVTAPNTAAQCDVITDALRSSDVAPESVNYVESHGTGTVLGDPIE
Rv2381c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2402c|M.bovis_AF2122/97 --------------------------------------------------
TH_3022|M.thermoresistible__bu --------------------------------------------------
MSMEG_4512|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2695|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2012|M.avium_104 --------------------------------------------------
MMAR_3695|M.marinum_M --------------------------------------------------
MUL_3638|M.ulcerans_Agy99 --------------------------------------------------
MAB_2119c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02356|M.leprae_Br4923 FEALAATYGRGESACALGAVKTNLGHLEAAAGIAGFIKTVLAVQRGQIPP
Rv2381c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2402c|M.bovis_AF2122/97 --------------------------------------------------
TH_3022|M.thermoresistible__bu --------------------------------------------------
MSMEG_4512|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2695|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2012|M.avium_104 --------------------------------------------------
MMAR_3695|M.marinum_M --------------------------------------------------
MUL_3638|M.ulcerans_Agy99 --------------------------------------------------
MAB_2119c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02356|M.leprae_Br4923 NLHFSQWNPAIDAASTRFFVPTENSSWPISDGQAGPRRAAVSSFGLGGTN
Rv2381c|M.tuberculosis_H37Rv -------------MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERF
Mb2402c|M.bovis_AF2122/97 -------------MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERF
TH_3022|M.thermoresistible__bu ---------MTPITRANSWPDGRIPVLLSAHAEDLLRADARALLDYLDRE
MSMEG_4512|M.smegmatis_MC2_155 ------------MMTDGTLCDHRVPVVLSAHAEDLIAHDATAILRYLDGR
Mvan_3846|M.vanbaalenii_PYR-1 -------------MSAGRLPDGRVAVPLSAHHEALVSATARDILGHLQ-R
Mflv_2695|M.gilvum_PYR-GCK -----------------MLPDGRIPVLLSAHAEELIGEDARRLLGFLD--
MAV_2012|M.avium_104 ------------MMPTHGLPDGRIPVLLSSHDPELIRRDAAAILEYLDRI
MMAR_3695|M.marinum_M -----------MSAAAYRLPDGTIPVLLSADTPELLDSEATALRDHVAAH
MUL_3638|M.ulcerans_Agy99 -----------MSAAAYRLPDGTIPVLLSADTPELLDSEATALRDHVAAH
MAB_2119c|M.abscessus_ATCC_199 ----------------------------------MLRREASALLAYVADH
MLBr_02356|M.leprae_Br4923 AHVVIEQGPELTPVTECSSNTAVSTLVVTGKTASRVAAMAGMLADWVEGP
: * : :
Rv2381c|M.tuberculosis_H37Rv --PATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEGLRALAAGREHPL
Mb2402c|M.bovis_AF2122/97 --PATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEGLRALAAGREHPL
TH_3022|M.thermoresistible__bu --PAAAVXXXX------------RAVIRAADRTELADGLRAVADGAEHRL
MSMEG_4512|M.smegmatis_MC2_155 --TDTAPSDVAYTLLRTRRLRRHRAVIRAGGLDELTAGLRALADGDDHPL
Mvan_3846|M.vanbaalenii_PYR-1 --NPSEPGQVAAQLVRTRRLRRHRAIVRAGDRDELAAGLQAVADDRDHPL
Mflv_2695|M.gilvum_PYR-GCK --SAPEVDAVAATLLRVRRRNRHRAVVRAADRSELADALSALAAGQEHPL
MAV_2012|M.avium_104 GESTEATGAVAATLLRLRRVRRHRALLRAADRAELAAGLAAIARGEEHAL
MMAR_3695|M.marinum_M --PDLTPGPISAMLFRTRAARRHRALAMVRTRAELIDALQAMIDRYEHPA
MUL_3638|M.ulcerans_Agy99 --PDLTPGPISAMLFRTRAARRHRALAMVRTRAELIDALQAMIDRYEHPA
MAB_2119c|M.abscessus_ATCC_199 --PRIAPNRIAGMIFRTRVARRYRALATVENHDQLVAALRTVVAGTEHPL
MLBr_02356|M.leprae_Br4923 G-AEVALADVAHTLNHHRSRHAKFGTVVARDRIQAVAGLRALAAGKQAPG
. . : .* :: :
Rv2381c|M.tuberculosis_H37Rv IARSSL---GSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAA
Mb2402c|M.bovis_AF2122/97 IARSSL---GSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAA
TH_3022|M.thermoresistible__bu VARSDH---STAPRLAFVFPGQGSQWPGMGAAAYRQFAEYRAGVDACAAA
MSMEG_4512|M.smegmatis_MC2_155 VTRAAAPQPGSRRRVAFVFPGQGSQWPSMGVEAYR-LDDYRAEVDRCAAA
Mvan_3846|M.vanbaalenii_PYR-1 VARSAG-RAGAR--TAFVFPGQGSQWPGMGGEAYRLLPVYRAEADRLTEA
Mflv_2695|M.gilvum_PYR-GCK VSRSAEP---DAHRRAFVYPGQGNQWPAMGAEAYRTLRDYRQAADVCAAA
MAV_2012|M.avium_104 ITRSAR---TTPPRIAFVFPGQGNQWQAMGADAYRRLPAYREAADRCAQA
MMAR_3695|M.marinum_M LIRTDPA--AIRRRIGYVFPGQGGQRPGMGQLFYESVPAFRAEVDRCAQA
MUL_3638|M.ulcerans_Agy99 LIRTDPA--AIRRRIGYVFPGQGGQRPGMGQLFYESVPAFRAEVDRCAQA
MAB_2119c|M.abscessus_ATCC_199 VVRNSEP--ATARRHGFVFPGQGGQRPGMGRLFYDAFPSFRAEVERCADL
MLBr_02356|M.leprae_Br4923 VVGQQDG--TPGSGTVFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPV
: :*:.*:*.: .** : .
Rv2381c|M.tuberculosis_H37Rv FAAAGVDSPLPYLIAPPGT-DERQAFCEIEIEGAQFVHAVALAEVWRSCG
Mb2402c|M.bovis_AF2122/97 FAAAGVDSPLPYLIAPPGT-DERQAFCEIEIEGAQFVHAVALAEVWRSCG
TH_3022|M.thermoresistible__bu FTAAGAPAPLRYLTTP----DDPESFCETEVEGAQFTHAVALARMWRHHG
MSMEG_4512|M.smegmatis_MC2_155 FEAAGAASPLDYLLAHPDSGVSTNDFSQVQIQGAQFVHGVALARVWRSHG
Mvan_3846|M.vanbaalenii_PYR-1 FLAAGLTSPLPFLTADTDG----EPVSQYDLQAAQFVHSVALAAVWRSCG
Mflv_2695|M.gilvum_PYR-GCK FTAAGAPSPLRYLTDAAAV-----TGSQVEAQAAQFTHAVALTAVWRAHG
MAV_2012|M.avium_104 FVAAGFPSPLPYLVSPDEQ-----SWTRPEIQGAQFTHAVALAEAWRCFG
MMAR_3695|M.marinum_M FEAQSCGSPRNYLLDKNFQ----DDGSAGIVQPALFTQMAALAAMWRSFG
MUL_3638|M.ulcerans_Agy99 FEAQACGSPRNYLLDKNFQ----DDGSAGIVQPALFTQMAALAAMWRSFD
MAB_2119c|M.abscessus_ATCC_199 FDKQFGRSPLSYLLDDQLP----TNDSATVVQPALFTQMVGLAALWRTVG
MLBr_02356|M.leprae_Br4923 FVVHAGFSLHDVLANGKEL------VGIEQIQLGLIGMQLTLTELWRSYG
* : * : . : *: ** .
Rv2381c|M.tuberculosis_H37Rv VLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGR-YAVA
Mb2402c|M.bovis_AF2122/97 VLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGR-YAVA
TH_3022|M.thermoresistible__bu VLPDITVGHSLGEVGAAYIAGAITLADAVSVVIARAGVVDRLPGR-YAVA
MSMEG_4512|M.smegmatis_MC2_155 VVPDITVGHSLGEIGAAYVAGAITLPEAVAIVIARATVLDRLTGP-YRVA
Mvan_3846|M.vanbaalenii_PYR-1 IVPDLTVGHSLGEVAAAYVAETVTLVDAVTVLAARAAAIEAIPGD-NGVA
Mflv_2695|M.gilvum_PYR-GCK VAPDMTVGHSLGEVAAAHVAGAITLAEAAAVVIARATVLEGLADG-YRMA
MAV_2012|M.avium_104 VLPEMAIGHSLGEVAAAYVAEAISLPDAVALVVARATVVDRLTGR-YAMA
MMAR_3695|M.marinum_M IAPNVTIGHSQGEVAAAYVSGTITLEDAVRVIGIRAHAADEFAAADYAMA
MUL_3638|M.ulcerans_Agy99 IPPNVTIGHSQGEVAAAYVSGTITLEDAVRVIGIRAHAADEFAAADYAMA
MAB_2119c|M.abscessus_ATCC_199 VTPRAVVGHSQGEIAGAYVSGVMSLDDAVTVVGTRAGIADEFPADDYAMA
MLBr_02356|M.leprae_Br4923 VQPDLVIGHSLGEVAAAVVAGALTAAEGLRVTATRSRLMAPLSGQ-GGMA
: * .:*** **:..* :: :: :. : *: :. :*
Rv2381c|M.tuberculosis_H37Rv ALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSS
Mb2402c|M.bovis_AF2122/97 ALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSS
TH_3022|M.thermoresistible__bu VLGVDADAARDVIASTPGWLELSVVNAPSSVAVSGDRDAVSAAVARVREQ
MSMEG_4512|M.smegmatis_MC2_155 VLGITPEQAAEVIAETPGWLELSVVNSPSSVAVSGETGAVAAAVRTVAAR
Mvan_3846|M.vanbaalenii_PYR-1 VLGVDATEAAELIAATGGWLELSAVNAQNSVAVSGERSAVAAIAAAARAR
Mflv_2695|M.gilvum_PYR-GCK VLGLTPEDAQSLIESVPGWLELAVVNAASSVGVSGERDAVDALLAQASSR
MAV_2012|M.avium_104 VLGAGAADAESLLATTPGWVEVSAVNGPASTVVAGDHDAVAAAVRLAQQR
MMAR_3695|M.marinum_M IVAADRETCEDLLARCSGWAQLSVVNSPRMVGISGERETVQGIVDTLTEG
MUL_3638|M.ulcerans_Agy99 IVAADREACEDLLARCSGWAQLSVVNSPRMVGISGERETVQGIVDTLTEG
MAB_2119c|M.abscessus_ATCC_199 VIATDRDTCEELLARNSGWAELSVINSPSMVGISGQRETVHQIVEHLIED
MLBr_02356|M.leprae_Br4923 LLELDAVETEALIVDYS-QVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQ
: :: :: *. . ::* :
Rv2381c|M.tuberculosis_H37Rv GHFARGITVGFPVHTSVLES----LRDELCEQLPDSEFMEAPVQFIGGTT
Mb2402c|M.bovis_AF2122/97 GHFARGITVGFPVHTSVLES----LRDELCEQLPDSEFMEAPVQFIGGTT
TH_3022|M.thermoresistible__bu GRFAREITVGFPVHTSILEP----LRDDLLRNLPQAEFADSPVQFIGAAT
MSMEG_4512|M.smegmatis_MC2_155 GAFAKEIEMWFPAHTTALDG----VRADLDALLPAGRFAETPVQFIGSAT
Mvan_3846|M.vanbaalenii_PYR-1 GRFAKELAMSFPAHTTAMET----QREQLVRRLPTSVFADSPVQFVGSAT
Mflv_2695|M.gilvum_PYR-GCK GVFARSVTMAFPAHTSLLDG----LRADFVRLLAPARFQQTAIPFLGSAT
MAV_2012|M.avium_104 EIFAHQLFVDYPGHTSALRP----LRAALAELTPQSAFRDSPIRFIGSTR
MMAR_3695|M.marinum_M GTFARVIRVRYPAHTSLIHDGADKLRAAIQDQLQHPSFVDTDIDCLGATL
MUL_3638|M.ulcerans_Agy99 GTFARVIRVRYPAHTSLIHDGADKLRAAIQDQLQHPSFVDTDIDCLGATL
MAB_2119c|M.abscessus_ATCC_199 GVFARVIPVRYPAHTSMIASIGAQIRHALTENLDAGEFTVSEIDCIGATL
MLBr_02356|M.leprae_Br4923 NRFASRVNIEVAPHNPAMDA----LQPQMRSELADVAPRTPTIPILSTTY
** : : . *.. : : : . : :. :
Rv2381c|M.tuberculosis_H37Rv GDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLF
Mb2402c|M.bovis_AF2122/97 GDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLF
TH_3022|M.thermoresistible__bu GDVVPAGTGFGPYWYGNLRHLVRFDRAFQTALRCGARTFVELSAHPSLLF
MSMEG_4512|M.smegmatis_MC2_155 ADVVTTGTDFADYWYTNLRTTVRFDQAVARAARRGARIFVELSAHPALLF
Mvan_3846|M.vanbaalenii_PYR-1 GQLVRAGTEFGAYWYANLRNTIRFDQAVQTAIGLGAGVYVELSAHPSLLF
Mflv_2695|M.gilvum_PYR-GCK GEAVPPETDFADYWFANLRNTVRFDRAAAAAVRAGANLFVEMSAHPALLF
MAV_2012|M.avium_104 GAEVAATTDYASYWYENLCSTVRFDLAVQCARSCGADAFVELSAHPSLLY
MMAR_3695|M.marinum_M GAPITSELPVGDYWFWNLRNIVRFDKAIAAAVQRDVETFVELAEHPTLQL
MUL_3638|M.ulcerans_Agy99 GAPITSELPVGDYCFWNLRNIVRFDKAIAAAVQRDVETFVELAEHPTLQL
MAB_2119c|M.abscessus_ATCC_199 GTAISPEMPVDQYWFWNLRNAVRFDRAVATAAAAHVDTFVELAEHPTLQL
MLBr_02356|M.leprae_Br4923 ADLGSCPVFDAQHWATNMRNPVHFQQAIMTAG-TDHRTFIEISAHPLLTQ
. : *: ::*: * * ::*:: ** *
Rv2381c|M.tuberculosis_H37Rv AIGQNCEGAANLP-DGPAVLVGSARRGERFVDALSANIVSAAVADPGYPW
Mb2402c|M.bovis_AF2122/97 AIGQNCEGAANLP-DGPAVLVGSARRGERFVDALSANIVSAAVADPGYPW
TH_3022|M.thermoresistible__bu AMSELLG-------DTPATLLGSTRRDEPIAETFTANLAAAAVSDPGYDW
MSMEG_4512|M.smegmatis_MC2_155 NMGELLEST------RGVVLVGSGRRDEPLPERLADNVITVALADAGYRW
Mvan_3846|M.vanbaalenii_PYR-1 AVEDGIERVG----AAAAVLVGSGHRDESVPDRLSANIVTAAAADPAYRW
Mflv_2695|M.gilvum_PYR-GCK SLGQSAG---------DALTVGSGRRDAPLVETLSAGIATVAAHDAEFPW
MAV_2012|M.avium_104 PLSGIID-------DESAVIVGSGHRDRPITESLSASMAAVATADPGYRW
MMAR_3695|M.marinum_M AIHENLAALRDEADDRPAMVVGTSERTATDLGEFTRNLAQLAVHDLNYPW
MUL_3638|M.ulcerans_Agy99 AIHENLAALRDEADDRPAMVVGTSERTATDLGEFTRNLAQLAVHDLNYPW
MAB_2119c|M.abscessus_ATCC_199 ALRENLAALGSE---RTACVVGTSHRNATDLGEFTANLAKIAVHDLDYNW
MLBr_02356|M.leprae_Br4923 AITDTLHG-------TRCISIGTLQRDADDTVTFHTNLNNVHTVHPPHTP
: :*: .* : .: . .
Rv2381c|M.tuberculosis_H37Rv GDLGGDPLDGD---VDLSGFPNAPMRAVPMWAHPEPLPP-----------
Mb2402c|M.bovis_AF2122/97 GDLGGDPLDGD---VDLSGFPNAPMRAVPMWAHPEPLPP-----------
TH_3022|M.thermoresistible__bu RAVTPAGPD------RLTGFPNAPMRAIPMWATAAPRRIGRAGG------
MSMEG_4512|M.smegmatis_MC2_155 RDQLGDCHA------VLPDFPFAPMRAEHLWAQPDPLPP-----------
Mvan_3846|M.vanbaalenii_PYR-1 GDLLTGEPE------PLFGFPGAPMRAEHLWAEPEPLPV-----------
Mflv_2695|M.gilvum_PYR-GCK HDVIDTTRP------ALRGFPNAPMRSVHLWALPQPLPA-----------
MAV_2012|M.avium_104 SETVPTRNQ-----PALHGFPNAPMRATHLWAAPDRVTEAAP--------
MMAR_3695|M.marinum_M ECLRAEPDGAQA--LPLLDFPNTRMNEIRLWLPYDEVLPRRQPP--SVSV
MUL_3638|M.ulcerans_Agy99 ECLRAEPDGAQA--LPMLDFPNTRMNEIRLWLPYDEVLPRRQPP--SVSV
MAB_2119c|M.abscessus_ATCC_199 DALRTEAPDRVS--LPLRDFPNVQNNDIPLWLSYRADTSGVAVPKQPIVT
MLBr_02356|M.leprae_Br4923 HPAEPHVTIPSTPWQHTRHWITTPLASTTALQHLDRNRVTTHATG-IGNT
: .
Rv2381c|M.tuberculosis_H37Rv -------------VSGLTIAVERWERMVP--STPVAGRHRHLAVLDLGA-
Mb2402c|M.bovis_AF2122/97 -------------VSGLTIAVERWERMVP--STPVAGRHRHLAVLDLGA-
TH_3022|M.thermoresistible__bu --------VRGEEAPGLRIAAEVWEPVAAQPGPASAATPVPVALLELGD-
MSMEG_4512|M.smegmatis_MC2_155 -------------VTGLTVAAEQWHQVAV--PEVSG--HHRIAVVGLDS-
Mvan_3846|M.vanbaalenii_PYR-1 -------------APGLTVTTETWRQRRP--RRVSAKVSRRVAVIESGS-
Mflv_2695|M.gilvum_PYR-GCK -------------PPSLTLATEAWEPHRP---AERGLALRRTAVLDLAGP
MAV_2012|M.avium_104 -------------RPRLTVAVEDWRHTTS-------PTTPTAADLGFAG-
MMAR_3695|M.marinum_M APAAPSVPDATADTTPARLLVEEWVRLSQ----RSLTPPRVVGIVDPTGA
MUL_3638|M.ulcerans_Agy99 APAAPSVPDATADTTPARLLVEEWVRLSQ----RSLTPPRVVGIVDPTGA
MAB_2119c|M.abscessus_ATCC_199 PEAERRVEMGNDSRAYPRLLREAWAKVTR----RSMMPPRSYAFIDGTGD
MLBr_02356|M.leprae_Br4923 ELDDWIYQLDWPTRPLTSEPGATWASSGSWLVVSDAGLSDELARLVVLAD
. * . :
Rv2381c|M.tuberculosis_H37Rv HRALAQTLCAAIDSH-------PDTELSAARDAELILVIAPDFEHTDAVR
Mb2402c|M.bovis_AF2122/97 HRALAQTLCAAIDSH-------PDTELSAARDAELILVIAPDFEHTDAVR
TH_3022|M.thermoresistible__bu TGRLGGWLRELLGNR-------PDVVLVGPEAAEVAVVAAPESDTAAPEA
MSMEG_4512|M.smegmatis_MC2_155 ECAVAGHLRDAAERI-------EGVEVVAPAAADTLLVVAPMISENDPVL
Mvan_3846|M.vanbaalenii_PYR-1 GTAISRSLRQAIDRR-------ADLSVAGAADADLAIVVAPTFAGADAAG
Mflv_2695|M.gilvum_PYR-GCK RGGLGDLLRDAVDHH-------PGMVSTPVHDADLVLAVAPNLGDPDVRE
MAV_2012|M.avium_104 AHPMTRRLADAAAAQ-------GGCRVVAPGEAEIVAIVAPELDQLDAVA
MMAR_3695|M.marinum_M CAQLATAMTAAAHQAGATARVVNGENDGTGADVNTLVILLPETPKLDGRA
MUL_3638|M.ulcerans_Agy99 CAQLATAMTAAAHQAGATARVVNGENDGTGADVNTLVILLPETPKLDGRA
MAB_2119c|M.abscessus_ATCC_199 AGALVEALRDSAPNFGSSARIVTGTDESGIGDADTVVIVLPSPALLDDHE
MLBr_02356|M.leprae_Br4923 PASRVEYLAPSALDHDVS---TLHDLHNALRGVDNVLYAPSVSTESVDPV
: .: .
Rv2381c|M.tuberculosis_H37Rv AAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAA
Mb2402c|M.bovis_AF2122/97 AAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAA
TH_3022|M.thermoresistible__bu GVAAITELVRAGGLRYPAAPGPHCRDVWLVTVGAEQVHPDDPVAPV-PAA
MSMEG_4512|M.smegmatis_MC2_155 AGEELGRRIDEGLLRYPDLLTETTRDVWLVTGRGEHVPVDRDGSLPVGAA
Mvan_3846|M.vanbaalenii_PYR-1 CVNELSGAIDTGLLGYADTFGPRCRDVWLVTVGAENVTAEDPAPDLGQAG
Mflv_2695|M.gilvum_PYR-GCK SVAALTALIDDGLLRYPDDVGTDCRDLWLVTTAAEQLTG-DPTPRPAQAA
MAV_2012|M.avium_104 AVEQIGAREDAGLPDYRGLIGPRCRAVWLLTVRAEHVDGDDDQACVAQAA
MMAR_3695|M.marinum_M AAAEVGGFFSN--RAWWPGVDTGVTDCWLVTVGGEAATAADGPPDPVHAA
MUL_3638|M.ulcerans_Agy99 AAAEVGGFFSN--RAWWPGVDTGVTDCWLVTVGGEAATAADGPPDPVHAA
MAB_2119c|M.abscessus_ATCC_199 AADAVARFFGN--RTWWPRLSSTVTGCWLVTVGGEQAIADDGPAHPVHAA
MLBr_02356|M.leprae_Br4923 DPESGYRLFHAVRRLAAAMVAGTSKPKLVVVTRNAQPVAVGERANPAHAV
::. . *
Rv2381c|M.tuberculosis_H37Rv LAAMHRSIGFEHPEQTFSHLDLPS-------WDLDPVLGVSVITAVLRGF
Mb2402c|M.bovis_AF2122/97 LAAMHRSIGFEHPEQTFSHLDLPS-------WDLDPVLGVSVITAVLRGF
TH_3022|M.thermoresistible__bu VAAMHRSLGLENPQIPFHHLDLEQGVGSDTARDTDPAVAALLMDAVLSAT
MSMEG_4512|M.smegmatis_MC2_155 VAAMHRSIAFEHPDQNFRQLDVPMGL--------DTEAAVTAVAAMVTGT
Mvan_3846|M.vanbaalenii_PYR-1 VAALHRCIGFEHPDQSFHHLDLPAG----------ATDALGAVDVMVDGA
Mflv_2695|M.gilvum_PYR-GCK LAAMHRSIGFEYPDRAFRHLDLPPVV-------LDEAAASAALDAVLGGG
MAV_2012|M.avium_104 LAAMHRSIGFEFPDQAFGHVDLPHR-------DVDAATAYAIIEVLLAEP
MMAR_3695|M.marinum_M ASAGFRSIGAEHPGVGFRHLDLPAG--------ATAQDWAHPIVAALHTA
MUL_3638|M.ulcerans_Agy99 ASAGFRSIGAEHPDVGFRHLDLPAG--------ATAQDWAHPIVAALHTA
MAB_2119c|M.abscessus_ATCC_199 IAAGFRCMGTEHPGIAFRHLDLTSD--------IASPDKADNILAALQSA
MLBr_02356|M.leprae_Br4923 LWGFGRTLALEHPEIWGSVIDLDASMP----PELAARCILDEVASQDEKD
. * :. * * :*: :
Rv2381c|M.tuberculosis_H37Rv G--ETALRGSVN---GYTLFERTLADAPAVPNWSLDS-GVLDDVVVTGGA
Mb2402c|M.bovis_AF2122/97 G--ETALRGSVN---GYTLFERTLADAPAVPNWSLDS-GVLDDVVVTGGA
TH_3022|M.thermoresistible__bu GGGGLAIRTTGA---GAVLYRRGLRDVPAPP--PLDRPGLLDEVVITGGA
MSMEG_4512|M.smegmatis_MC2_155 T--DLALRCDVADGPGTTLWRRGMRDASAAAAPWP--TGVLDDVVITGGT
Mvan_3846|M.vanbaalenii_PYR-1 G--ELALRRDGQ------VYERTLGDDTSTAPPWDLSSGTLDNVVITGGS
Mflv_2695|M.gilvum_PYR-GCK D--DLALRDIDG---MPAVFARTEHETVTTPESWADDPGALDHVVITGGS
MAV_2012|M.avium_104 A--EVALRGEQS----PRRHVRTFRAHHESADRPLDD-AALEHVVITGGS
MMAR_3695|M.marinum_M NEPELAYRDGAF-------YAKRIVAG-EGAVVHGAG-ACPEHVLIIGGT
MUL_3638|M.ulcerans_Agy99 NEPELAYRDGAF-------YAKRIVAG-EGAVVHGAG-ACPEHVLIIGGT
MAB_2119c|M.abscessus_ATCC_199 GESELALRADGM-------YAKRVLDIDQDGDESSRV-VAPAHVVITGGT
MLBr_02356|M.leprae_Br4923 REDQVVYRACLR------RAPRLQRRTASAVSSVKLSSGQDTTQLVIGAT
. * : :: *.:
Rv2381c|M.tuberculosis_H37Rv GAIGMHYARYLAEHGARRIVLLSRRA---ADQATVAMLRKQHGTVIVSPP
Mb2402c|M.bovis_AF2122/97 GAIGMHYARYLAEHGARRIVLLSRRA---ADQATVAMLRKQHGTVIVSPP
TH_3022|M.thermoresistible__bu GAIGLHYARQLARRGAKRIVLLSRRP---VDPAELAALAAPTGAEVLSVS
MSMEG_4512|M.smegmatis_MC2_155 GAVGLQFARRLAALGARRIVLLSRNG---IEGNRVDEL--PLGVEIVAPR
Mvan_3846|M.vanbaalenii_PYR-1 GAIGLSFARFLAARGARRIVLLSRRG---AGPAPLDN----LGAEIIAPA
Mflv_2695|M.gilvum_PYR-GCK GTVGQHYARHLAERGARRITLLSRHG---AKGS------AAGGPGVQTVC
MAV_2012|M.avium_104 GAIGLHYARYCLQRGARNLTLLSRNG---IEAAVLRELTGSHDARVSAPR
MMAR_3695|M.marinum_M GNLGLEFCDHFAHRGARRITLVSRSGESAAVAERLAQLRSATAAQIAVTR
MUL_3638|M.ulcerans_Agy99 GNLGLESCDHFAHRGARRITLVSRSGESAAVAERLAQLRSATAAQIAVTR
MAB_2119c|M.abscessus_ATCC_199 GKLGQEFCEHYARMGTRQITLISRSGETDAVTGRLDAIRRSTGAKVRALP
MLBr_02356|M.leprae_Br4923 GNIGPHLIRQLAAMGATTIVAVSRNP--STRLLELDKNLAATGTNLISVA
* :* *: :. :** :
Rv2381c|M.tuberculosis_H37Rv CDITDPTQLS--------------------------------------AI
Mb2402c|M.bovis_AF2122/97 CDITDPTQLS--------------------------------------AI
TH_3022|M.thermoresistible__bu CDLTDPDAVXXXXVRAVLTAAERAHRHGGDPREVLWQAWHRSGLQRRWLA
MSMEG_4512|M.smegmatis_MC2_155 CDLTDIPRVR--------------------------------------DV
Mvan_3846|M.vanbaalenii_PYR-1 CDLRDPRQLA--------------------------------------AT
Mflv_2695|M.gilvum_PYR-GCK CDVTDPVALA--------------------------------------VA
MAV_2012|M.avium_104 CDITDRAAVT--------------------------------------EA
MMAR_3695|M.marinum_M CDVGDPAAVS--------------------------------------RL
MUL_3638|M.ulcerans_Agy99 CDVGDPAAVS--------------------------------------RL
MAB_2119c|M.abscessus_ATCC_199 CDVTDTAAVT--------------------------------------AL
MLBr_02356|M.leprae_Br4923 ADATDPTAMT--------------------------------------AL
.* * :
Rv2381c|M.tuberculosis_H37Rv AAEYGGVG------------------ASLIVHAAGSVISG----------
Mb2402c|M.bovis_AF2122/97 AAEYGGVG------------------ASLIVHAAGSVISG----------
TH_3022|M.thermoresistible__bu ASERGGVAGVQADRDLDAVTAFFDAAEQYVARTAGATLRGLIDHLTTLGP
MSMEG_4512|M.smegmatis_MC2_155 AAEFGGQG------------------ASLIVHAAATATIA----------
Mvan_3846|M.vanbaalenii_PYR-1 VAEFAGGP------------------ASLIIHAAGTATFA----------
Mflv_2695|M.gilvum_PYR-GCK AAEFGGDG------------------ATLVIHAAGTAQFA----------
MAV_2012|M.avium_104 AARYAGSG------------------ATLLIHTAGIAQAR----------
MMAR_3695|M.marinum_M AAQHRSTP------------------ADLIIHAAVAYASV----------
MUL_3638|M.ulcerans_Agy99 AAQHRSTP------------------ADLIIHAAVAYASV----------
MAB_2119c|M.abscessus_ATCC_199 ADQLRDTP------------------ADLIVHAAVDYSDT----------
MLBr_02356|M.leprae_Br4923 FDRFGVDLP-----------------PLEGIYLAAFAGRP---------V
. *
Rv2381c|M.tuberculosis_H37Rv TAPGVTSAAVVDNFAAK-------------------------------VL
Mb2402c|M.bovis_AF2122/97 TAPGVTSAAVVDNFAAK-------------------------------VL
TH_3022|M.thermoresistible__bu AAPARDQSARRDAVAVLSAHAALDREWDLVVIAGLQDGLWPNTVPRGGVL
MSMEG_4512|M.smegmatis_MC2_155 AGSALTGAAAQATFTAK-------------------------------LA
Mvan_3846|M.vanbaalenii_PYR-1 NRADITGAALADMAGAK-------------------------------II
Mflv_2695|M.gilvum_PYR-GCK EHDTLSAAAFADTAAAK-------------------------------VE
MAV_2012|M.avium_104 SRTDLTGADVAAVCAAK-------------------------------VR
MMAR_3695|M.marinum_M EFSDITTDDADNALYAK-------------------------------VV
MUL_3638|M.ulcerans_Agy99 EFSDITTDDADNALYAK-------------------------------VV
MAB_2119c|M.abscessus_ATCC_199 PLSEVTTNKFQDALRAK-------------------------------VI
MLBr_02356|M.leprae_Br4923 LLSDMTDNDVVAMFRPK--------------------------------L
Rv2381c|M.tuberculosis_H37Rv GLAQMIELWP---------------LRPDVRTLLCSSVMGVWGGHGVVAY
Mb2402c|M.bovis_AF2122/97 GLAQMIELWP---------------LRPDVRTLLCSSVMGVWGGHGVVAY
TH_3022|M.thermoresistible__bu ATQQLVDVLDGVADGSDPVVSRRAPLLAEERRLLIAAMGRARSRLLVTAV
MSMEG_4512|M.smegmatis_MC2_155 GIENVLAAWP---------------VRPDARILLCSSVSGLWGGHGHAAY
Mvan_3846|M.vanbaalenii_PYR-1 GLEALTRTWP---------------IRDDARILLCSSVTGVWGGKGVGGY
Mflv_2695|M.gilvum_PYR-GCK GLFRIAEAWP---------------RRPGARMLVCSSVSGLWGGRGHAAY
MAV_2012|M.avium_104 GLALMADVWP---------------LRPDCRILACSSVFGVWGGYHHAAY
MMAR_3695|M.marinum_M GIGQVLDAFP---------------RTDGCRIVLCSSARATIGGRGQVMY
MUL_3638|M.ulcerans_Agy99 GIGQVLDAFP---------------RTDGCRIVLCSSARATIGGRGQVMY
MAB_2119c|M.abscessus_ATCC_199 GISNVLDTVP---------------RTDSCRVMLCSSLAATIGGKGQLMY
MLBr_02356|M.leprae_Br4923 DVASLLHRLS--------------LKQPVKYFLLFSSISGLIGSRWLAHY
: : :: .
Rv2381c|M.tuberculosis_H37Rv SAAN----RLLDVMAAQLRAQGRHCVAVKWG-------------------
Mb2402c|M.bovis_AF2122/97 SAAN----RLLDVMAAQLRAQGRHCVAVKWG-------------------
TH_3022|M.thermoresistible__bu DSDDGDESLLPSPFCAELAALATEPEAATPAPLPAPRVLTAAALVGRLRS
MSMEG_4512|M.smegmatis_MC2_155 AAAN----RLLDVMAERLRSEGRRCTAVRWG-------------------
Mvan_3846|M.vanbaalenii_PYR-1 AAAN----RMLDVMAARLGADGRNCTAVRFG-------------------
Mflv_2695|M.gilvum_PYR-GCK AAAN----RLVDVTAAQMRAEGIRCAAVRFG-------------------
MAV_2012|M.avium_104 AASN----RMLDVLATQLRARGLDCTAIRWG-------------------
MMAR_3695|M.marinum_M AAAN----RMLDAMAHRLRAEGLDCVSVQWG-------------------
MUL_3638|M.ulcerans_Agy99 AAAN----RMLDAMAHRLRAEGLDCVSVQWG-------------------
MAB_2119c|M.abscessus_ATCC_199 AAGN----RMLDVLASTRRASGLDCTSIQWG-------------------
MLBr_02356|M.leprae_Br4923 TATS----AFLDILGYARRLVGLPATVVAWG-------------------
: . : . . .
Rv2381c|M.tuberculosis_H37Rv -LWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF-----
Mb2402c|M.bovis_AF2122/97 -LWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF-----
TH_3022|M.thermoresistible__bu VVCAAPDTVDDEVRAGAATQLARLAAAGVPGADPAQWYAMTPLSTGEPLW
MSMEG_4512|M.smegmatis_MC2_155 -LWPG-------AGIIDADEITRVERSGLRAMAPDRAVDTALQDFA----
Mvan_3846|M.vanbaalenii_PYR-1 -LWEG-------SGIVDAAEIARVERTGLRQMKPELAVEASLCDFP----
Mflv_2695|M.gilvum_PYR-GCK -LFGT--------GIVDEESVNLIGRSGLVPLDPDDAVAASLRDLP----
MAV_2012|M.avium_104 -LWQD-------AGVVAGSEIARTERSGLVAMDPRRALQASLHRYE----
MMAR_3695|M.marinum_M -QWTVH-------FDLDASSMAQLAAIGVIPMPPAEAIALGMQRLG----
MUL_3638|M.ulcerans_Agy99 -QWTVH-------FDLDASSMAQLAAIGVIPMPPAEAIALGMQRLG----
MAB_2119c|M.abscessus_ATCC_199 -QWTVH-------LDLGDAGIAKLAAAGVHPMRPADALAVGMGHHH----
MLBr_02356|M.leprae_Br4923 -LWKS-------LADAQQDATQVSAESGLQPMTDDVAIGALPLVMSP---
*:
Rv2381c|M.tuberculosis_H37Rv ---------------------------------------TVDPLVFAADA
Mb2402c|M.bovis_AF2122/97 ---------------------------------------TVDPLVFAADA
TH_3022|M.thermoresistible__bu DGPGQSVTLSPSTLQTLVDCPLRWLLERHGGTDGRDVRSTVGSLVHALAA
MSMEG_4512|M.smegmatis_MC2_155 ----------------------------------------GDPLVFSADA
Mvan_3846|M.vanbaalenii_PYR-1 ----------------------------------------RDPLVLAADR
Mflv_2695|M.gilvum_PYR-GCK ----------------------------------------GDPIVYSADR
MAV_2012|M.avium_104 ----------------------------------------SDPLIFDADF
MMAR_3695|M.marinum_M ----------------------------------------RNAIVAAFDF
MUL_3638|M.ulcerans_Agy99 ----------------------------------------RNAIVAAFNF
MAB_2119c|M.abscessus_ATCC_199 ----------------------------------------GNTLVGAFDL
MLBr_02356|M.leprae_Br4923 -------------------------------------DAPVHSVVAAADW
.::
Rv2381c|M.tuberculosis_H37Rv AR------------------------------------LQMLLDSRQ---
Mb2402c|M.bovis_AF2122/97 AR------------------------------------LQMLLDSRQ---
TH_3022|M.thermoresistible__bu GRYRTEGQLLAELERVWDQLPFESRWYADNELSRHRAMLQTFMRWRERTR
MSMEG_4512|M.smegmatis_MC2_155 QR------------------------------------LALFLGTDA---
Mvan_3846|M.vanbaalenii_PYR-1 DR------------------------------------MRMFFGEKP---
Mflv_2695|M.gilvum_PYR-GCK AR------------------------------------LQIFRDDPAP--
MAV_2012|M.avium_104 ER------------------------------------LQVFFESQG---
MMAR_3695|M.marinum_M DRAR--------------------------------PVLETFGYGPLVS-
MUL_3638|M.ulcerans_Agy99 DRAR--------------------------------PVLETFGYGPLVS-
MAB_2119c|M.abscessus_ATCC_199 TQAR--------------------------------AMLGVFGYGPLLS-
MLBr_02356|M.leprae_Br4923 PLLAAAYQTRG--------------------------VLRMVDDLLPAPG
: .
Rv2381c|M.tuberculosis_H37Rv -------------------------------FERYEGPTDPNLTIVDAVR
Mb2402c|M.bovis_AF2122/97 -------------------------------FERYEGPTDPNLTIVDAVR
TH_3022|M.thermoresistible__bu RELTEVAAEIAVDGVLVDGADTTPEIRVRGRLDRLERDADGRLVVVDLKT
MSMEG_4512|M.smegmatis_MC2_155 -------------------------------DTGTGREATHAAQHRDAGP
Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------VEKPGEADTGAGPASMAPP
Mflv_2695|M.gilvum_PYR-GCK --------------------------------PTATSPASGGDTTAVVLA
MAV_2012|M.avium_104 -------------------------------MPMPFSDTPTRDDEAAAAP
MMAR_3695|M.marinum_M ------------------------------ELLS---PVS----ETAAPA
MUL_3638|M.ulcerans_Agy99 ------------------------------ELLS---PVS----ETAAPA
MAB_2119c|M.abscessus_ATCC_199 ------------------------------ELEDNGGPVAPAETTRPAPV
MLBr_02356|M.leprae_Br4923 ------------------------------EVLMQESEFRKALRTCQAER
Rv2381c|M.tuberculosis_H37Rv ------------------TQLAAVLGIPQAGEVNLQESLFDLGVDSMLAL
Mb2402c|M.bovis_AF2122/97 ------------------TQLAAVLGIPQAGEVNLQESLFDLGVDSMLAL
TH_3022|M.thermoresistible__bu GKSPVTKNDAQRHAQLAMYQLAVAAGLLPAGDIPGGGRLVYLGRPTGGGA
MSMEG_4512|M.smegmatis_MC2_155 P----ADAEHHDTGAAVRIALAAVLKLADTTGLDLDASLLDLGVDSLLAL
Mvan_3846|M.vanbaalenii_PYR-1 --------------DAVRTQLAAVLD-VDAAALDLDSPLFDLGVDSLLAL
Mflv_2695|M.gilvum_PYR-GCK -------------------ELTSVLGIEPAG-VDLDASLLDMGVDSLLAL
MAV_2012|M.avium_104 AG--------KPLAEVVRAELAATLHLGDSVSIDPSASLIDLGVDSLLAL
MMAR_3695|M.marinum_M EP--------ADLPGRLSNLLAAAIGAERAERIDTSVPMVALGLDSLQAL
MUL_3638|M.ulcerans_Agy99 EP--------ADLPGRLSNLLAAAIGAERAERIDTSVPMVALGLDSLQAL
MAB_2119c|M.abscessus_ATCC_199 VS--------ENRSGHLVQLLAEVIGADHADSIDTAMPMVAMGLDSLQAL
MLBr_02356|M.leprae_Br4923 RHN--------MLFDHVSALVAKAMGLLPAETLDPSAGFFQLGMDSLMSV
:: . : : :. :* : .
Rv2381c|M.tuberculosis_H37Rv DLRNR----LKRSIGATVSLATLMGDITGDGLVAKLEDADER-----SHT
Mb2402c|M.bovis_AF2122/97 DLRNR----LKRSIGATVSLATLMGDITGDGLVAKLEDADER-----SHT
TH_3022|M.thermoresistible__bu TEREQDPLTPETAAGWRDTVAQAADATRGPRFAARINDGCAHCPVRFSCP
MSMEG_4512|M.smegmatis_MC2_155 DLRKK----LKKTTGRSVPLATLLGGVTATELIEHLER------------
Mvan_3846|M.vanbaalenii_PYR-1 DLRKR----LKRLTGHTVPLATLLGGITGADLIAGLS-------------
Mflv_2695|M.gilvum_PYR-GCK DLRKR----LRRATGRSVPLAAMLGGMTGAELITGLDD-----------E
MAV_2012|M.avium_104 DLRKR----LRRTVGNSVPVARMLGGITVAELVDALRADATGGPVVPPTI
MMAR_3695|M.marinum_M ELRRR----VKAEFDHELEVSDLLGGASIADVLAQLGSR-----------
MUL_3638|M.ulcerans_Agy99 ELRRR----VKAEFDHELEVSDLLGGASIADVLAQLGSR-----------
MAB_2119c|M.abscessus_ATCC_199 EFRRR----VQAELDFELPVQDLLGGASVDHVIDALTAQSR---------
MLBr_02356|M.leprae_Br4923 TLQRA----LSDSLGEFLPASVVFDYPTVYSLTDYLATILPEFLEPEAPS
:. . . . :
Rv2381c|M.tuberculosis_H37Rv AQKVDISRD-------------------
Mb2402c|M.bovis_AF2122/97 AQKVDISRD-------------------
TH_3022|M.thermoresistible__bu AQAAQAGSERP-----------------
MSMEG_4512|M.smegmatis_MC2_155 PEKETFSRD-------------------
Mvan_3846|M.vanbaalenii_PYR-1 -EKVNTSSD-------------------
Mflv_2695|M.gilvum_PYR-GCK PQRNEIPA--------------------
MAV_2012|M.avium_104 QRTGAVSGAHPSKLAMLERLDS------
MMAR_3695|M.marinum_M ----------------------------
MUL_3638|M.ulcerans_Agy99 ----------------------------
MAB_2119c|M.abscessus_ATCC_199 ----------------------------
MLBr_02356|M.leprae_Br4923 GRTTADAYDEFTESELLDQLSERLRGTQ