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M. thermoresistible (build 8) TH_2393 (-)

annotation: D-alanyl-D-alanine carboxypeptidase
coordinates: 4676026 - 4676925
length: 300

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2393--100% (300)D-alanyl-D-alanine carboxypeptidase
M. thermoresistible (build 8)TH_2392-2e-8556.99% (279) D-alanyl-D-alanine carboxypeptidase
M. thermoresistible (build 8)TH_1977-8e-5647.72% (241) PROBABLE PENICILLIN-BINDING PROTEIN DACB1 (D-ALANYL-D-ALANINE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2935dacB23e-8859.85% (274) D-alanyl-D-alanine carboxypeptidase
M. gilvum PYR-GCKMflv_4179-7e-8756.06% (289) Serine-type D-Ala-D-Ala carboxypeptidase
M. tuberculosis H37RvRv2911dacB23e-8859.85% (274) D-alanyl-D-alanine carboxypeptidase
M. leprae Br4923MLBr_00691-9e-5445.49% (255) putative D-alanyl-D-alanine carboxypeptidase
M. abscessus ATCC 19977MAB_3234-4e-8559.06% (276) D-alanyl-D-alanine carboxypeptidase DacB
M. marinum MMMAR_1797dacB3e-8557.09% (275) D-alanyl-D-alanine carboxypeptidase DacB
M. avium 104MAV_3766-4e-8657.76% (277) D-alanyl-D-alanine carboxypeptidase
M. smegmatis MC2 155MSMEG_2433-2e-8657.30% (281) D-alanyl-D-alanine carboxypeptidase
M. ulcerans Agy99MUL_2045dacB3e-8556.73% (275) D-alanyl-D-alanine carboxypeptidase DacB
M. vanbaalenii PYR-1Mvan_2184-1e-8857.65% (281) Serine-type D-Ala-D-Ala carboxypeptidase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4179|M.gilvum_PYR-GCK          ------------------------------MNTTGRAGRGWIDFPVMTRL
Mvan_2184|M.vanbaalenii_PYR-1       ----------------------------------------------MTRL
MSMEG_2433|M.smegmatis_MC2_155      ----------------------------------------------MWR-
Mb2935|M.bovis_AF2122/97            --------------------------------------------------
Rv2911|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_1797|M.marinum_M               --------------------------------------------------
MUL_2045|M.ulcerans_Agy99           --------------------------------------------------
MAV_3766|M.avium_104                ----------------------------------------------MDRK
MAB_3234|M.abscessus_ATCC_1997      --------------------------------------------------
TH_2393|M.thermoresistible__bu      -------------------------------------VRATTDRPRRPRL
MLBr_00691|M.leprae_Br4923          MSFLRSTACLAAAVFAIVGPVALDLPTAVPVGHAEPNAGPNAGPATCPYQ
                                                                                      

Mflv_4179|M.gilvum_PYR-GCK          LASLGAALCLILAGSGVVSPTASAVPVT---GIVQPAGSVPVPDGP----
Mvan_2184|M.vanbaalenii_PYR-1       LACLGAVLCLVGS---VSVPHAAAVPAT---GIVQPAGSMPIPDGP----
MSMEG_2433|M.smegmatis_MC2_155      -YAFGLVVLVVSG--LITGPGSLAVPVARADADIQQVGSVAPPEGP----
Mb2935|M.bovis_AF2122/97            -----MRKLMTATAALCACAVTVSAGAAWADADVQPAGSVPIPDGP----
Rv2911|M.tuberculosis_H37Rv         -----MRKLMTATAALCACAVTVSAGAAWADADVQPAGSVPIPDGP----
MMAR_1797|M.marinum_M               -----MRKVMAVAAALLT-AATISGATASADTEMQPAGSVPIPDGP----
MUL_2045|M.ulcerans_Agy99           -----MRKVMAVAAVLLT-AATISGATASADTEMQPAGSVPIPDGP----
MAV_3766|M.avium_104                LDFAAMRKLWTAAAALLL--VGACGAPTAAADSTQPAGSIPIPDGP----
MAB_3234|M.abscessus_ATCC_1997      -MSDPMSTLRIRALAVLSVLFLSTLPVG----VARADMAAPPPEGP----
TH_2393|M.thermoresistible__bu      RSRPSRNALLATLFAIALSVSGIAAPESS--AQPEPVRAMSVPDGP----
MLBr_00691|M.leprae_Br4923          VSTPPAVDSSEVPQTGNPPMPLAVPPKPVGGAALNSCGIVTAPDTPPVPG
                                                                      .     . *: *    

Mflv_4179|M.gilvum_PYR-GCK          ---AQAWVLADMDTGAVLAARQENGRFAPASTIKILLAMVVLDELPLDAT
Mvan_2184|M.vanbaalenii_PYR-1       ---AQAWIVADMDTGAVLAARDEHGHFAPASTIKVLLAMVVLDELPLDAT
MSMEG_2433|M.smegmatis_MC2_155      ---AETWVVADMDTGQILAGRGEYVRHAPASTIKTLLALVVLDEVPLDST
Mb2935|M.bovis_AF2122/97            ---AQTWIVADLDSGQVLAGRDQNVAHPPASTIKVLLALVALDELDLNST
Rv2911|M.tuberculosis_H37Rv         ---AQTWIVADLDSGQVLAGRDQNVAHPPASTIKVLLALVALDELDLNST
MMAR_1797|M.marinum_M               ---AQTWIVADLDTGQVLAGRDQNVTHPPASTIKVLLALVALDELDLNST
MUL_2045|M.ulcerans_Agy99           ---AQTWIVADLDTGQVLAGRDQNVTHPPASTIKVLLALVALDELNLNST
MAV_3766|M.avium_104                ---AQTWIIADLDSGQVLAGRDPNVAHPPASTIKTLLAQVVLDEVSLDAT
MAB_3234|M.abscessus_ATCC_1997      ---AQAWLVADLDSGQILAARDPYATHAPASTIKVLLALVALDEVPMDAT
TH_2393|M.thermoresistible__bu      ---APAWLLADLDTGQVLAAREPHVHRAPASTIKVLLAIVALDQLPLNAT
MLBr_00691|M.leprae_Br4923          DLSAEAWLVADLNSGAVIAARDPHGRHRPASIIKVLLAMASINTLNLNKS
                                       * :*::**:::* ::*.*       *** ** *** . :: : :: :

Mflv_4179|M.gilvum_PYR-GCK          VVANEADTRVECNCAGVAPGTTYTTRQLLEGLLLVSGNDAANTLATMLGG
Mvan_2184|M.vanbaalenii_PYR-1       IVANEADTLVECNCAGVTPGRTYTTRQLLEALLLVSGNDAANTLATMLGG
MSMEG_2433|M.smegmatis_MC2_155      IVADETDTDVECNCAGVAPGRTYTARQLLEAALLASGNDAANTLARMLGG
Mb2935|M.bovis_AF2122/97            VVADVADTQAECNCVGVKPGRSYTARQLLDGLLLVSGNDAANTLAHMLGG
Rv2911|M.tuberculosis_H37Rv         VVADVADTQAECNCVGVKPGRSYTARQLLDGLLLVSGNDAANTLAHMLGG
MMAR_1797|M.marinum_M               VVADEADTHVECNCVGVKAGHTYTARQLLDGLLLVSGNDAANTLAQMLGG
MUL_2045|M.ulcerans_Agy99           VVADEADTHVECNCVGVKAGHTYTARQLLDGLLLVSGNDAANTLAQLLGG
MAV_3766|M.avium_104                VVADAADTQVECNCVGIKPGRSYTARQLLDALLLVSGNDAANTLAHMLGG
MAB_3234|M.abscessus_ATCC_1997      VVADAADAKAECNCVGIKAGQTYTARELLDAALLESGNDAANTLAHLLGG
TH_2393|M.thermoresistible__bu      VRAGAAAADEVCSCAGIRPGRVYSTRQLLDAVLLISGNDAANTLADMLGG
MLBr_00691|M.leprae_Br4923          VAGTAEDAAAEGTKVGVHDGGTYTINQLLHGLLMQSGNDAAHSLAMQLGG
                                    : .    :    . .*:  *  *: .:**.. *: ******::**  ***

Mflv_4179|M.gilvum_PYR-GCK          RDAAVAKMNAKAAGLGAHGTRAGSPSGIDGPGIDIWSTPRDLAVLFRAAM
Mvan_2184|M.vanbaalenii_PYR-1       RDVAVMKMNAKAATLGAYGTNAGSPSGIDGPGIDIWSTPRDLAVIFRAAM
MSMEG_2433|M.smegmatis_MC2_155      PEAAVAKMNAKAAQLGARDTNVVTPSGLDAPGMPFWSTPHDLAVIFRAAM
Mb2935|M.bovis_AF2122/97            QDVTVAKMNAKAATLGATSTHATTPSGLDGPGGSGASTAHDLVVIFRAAM
Rv2911|M.tuberculosis_H37Rv         QDVTVAKMNAKAATLGATSTHATTPSGLDGPGGSGASTAHDLVVIFRAAM
MMAR_1797|M.marinum_M               QDAAVAKMNAKAAALGAMNTHAATPSGLDGPGGSGWSTAHDLAVIFRTAM
MUL_2045|M.ulcerans_Agy99           QDAAVAKMNAKAAALGAMNTHAATPSGLDGPGGSGWSTAHDLAVIFRTAM
MAV_3766|M.avium_104                PEATVAKMNAKAAALGATNTHASTPSGLDGPNGSGSSTAHDLAVIFRAAM
MAB_3234|M.abscessus_ATCC_1997      RQATVDKMNAKAAALGATSTHTDSPSGLDAPGMDMRTSPHDLAVIFRAAL
TH_2393|M.thermoresistible__bu      RQVTVAKMNAKAYQIGARNTRVTSPSGLDVPGVDMVTTPHDLALIFRTAL
MLBr_00691|M.leprae_Br4923          MQQALQKINVLAAKLGGQDTRVATPSGLDGPGMS--TSAYDIGLFYRYAW
                                     : :: *:*. *  :*. .*.. :***:* *.    ::. *: :::* * 

Mflv_4179|M.gilvum_PYR-GCK          AYPVFAQITAQPTAVFP--TKSGDVVLVNQDEMLHRYPGTFGGKTGYTDL
Mvan_2184|M.vanbaalenii_PYR-1       ADPVFAQIVAQPTAVFP--AKTGDVVLVNQDELLHRYPGTFGGKTGYTDL
MSMEG_2433|M.smegmatis_MC2_155      ADPVFAQITAMPSTVFP--AKTGDRVLVNQNELLHRYPGTLGGKTGFTDI
Mb2935|M.bovis_AF2122/97            ANPVFAQITAEPSAMFP--SDNGEQLIVNQDELLQRYPGAIGGKTGYTNA
Rv2911|M.tuberculosis_H37Rv         ANPVFAQITAEPSAMFP--SDNGEQLIVNQDELLQRYPGAIGGKTGYTNA
MMAR_1797|M.marinum_M               ANPVFAHITAEPSAMFP--GEDGEHPIVNQDELLQRYPGAIGGKTGYTNA
MUL_2045|M.ulcerans_Agy99           ANPVFAHITAEPSAMFP--GEDGEHPIVNQDELLQRYPGAIGGKTGYTNA
MAV_3766|M.avium_104                ANPVFAQITAEPSAMFP--GDNGLQPITNQDELLQRYPGAIGGKTGFTNA
MAB_3234|M.abscessus_ATCC_1997      ANPVFAEITAQPSAPFP--GRG----LHNQNELMYRYPGVIGGKTGFTDI
TH_2393|M.thermoresistible__bu      RYPAFVNIISQPWTMFP--SDNGFRQIVNQNELLKRYPGTIGGKTGYTKI
MLBr_00691|M.leprae_Br4923          QNPSFSNIVATRTFNFPGPGDHPGYQLENDNQLLYQYPGALGGKTGYTDD
                                      * * .* :     **         : *::::: :***.:*****:*. 

Mflv_4179|M.gilvum_PYR-GCK          ARKTFVAGASRNGRHLVVAMMYGLVTEGGPTYWDQASALLDWGFALGPNA
Mvan_2184|M.vanbaalenii_PYR-1       ARKTFVGGAARNGRHLVVALMYGLVKEGGPTYWDQAAALLDWGFALGPNS
MSMEG_2433|M.smegmatis_MC2_155      ARKTFVAAAQRDGRRLVIAMMYGLVKEGGPTYWDQAAGLLDWGFAQDRSA
Mb2935|M.bovis_AF2122/97            ARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQAATLFDWGFALNPQA
Rv2911|M.tuberculosis_H37Rv         ARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQAATLFDWGFALNPQA
MMAR_1797|M.marinum_M               ARKTFVGAAARNGRRLVIAMMYGLVKEGGPTYWDQAGSLFDWGFALNPQS
MUL_2045|M.ulcerans_Agy99           ARKTFVGAAARNGRRLVIAMMYGLVKEGGPTYWDQAGSLFDWGFALNPQS
MAV_3766|M.avium_104                ARKTFVGAAARGGRRLVIAMMYGLIKEGGPSYWDQAATLFDWGFAQSPQA
MAB_3234|M.abscessus_ATCC_1997      ARKTYVVAAERDGKRLVVSMMYGLVHEGGPTYWDQAASLFDWGFVNDGSS
TH_2393|M.thermoresistible__bu      ARKTYVGAAQRNGRRLVIVQMGGMDQPGR-TYWDQAVDLFNWGFSQYR--
MLBr_00691|M.leprae_Br4923          AGQTFVGAANRNGRRLMAVLLHGT--RQPIAPWEQAAHLLDYGFSTAVGT
                                    * :*:* .* *.*::*:   : *       : *:**  *:::**      

Mflv_4179|M.gilvum_PYR-GCK          GVSRL---------------------------------------------
Mvan_2184|M.vanbaalenii_PYR-1       GVSRL---------------------------------------------
MSMEG_2433|M.smegmatis_MC2_155      SIGAL---------------------------------------------
Mb2935|M.bovis_AF2122/97            SVGSL---------------------------------------------
Rv2911|M.tuberculosis_H37Rv         SVGSL---------------------------------------------
MMAR_1797|M.marinum_M               GIGSL---------------------------------------------
MUL_2045|M.ulcerans_Agy99           GIGSL---------------------------------------------
MAV_3766|M.avium_104                SIGSL---------------------------------------------
MAB_3234|M.abscessus_ATCC_1997      SVGSL---------------------------------------------
TH_2393|M.thermoresistible__bu      --------------------------------------------------
MLBr_00691|M.leprae_Br4923          QIGTLIEPDPTVAGNADRHGHGLQAAGIMSSNDTLPVRIGVAVVGTLIVF
                                                                                      

Mflv_4179|M.gilvum_PYR-GCK          ---------------
Mvan_2184|M.vanbaalenii_PYR-1       ---------------
MSMEG_2433|M.smegmatis_MC2_155      ---------------
Mb2935|M.bovis_AF2122/97            ---------------
Rv2911|M.tuberculosis_H37Rv         ---------------
MMAR_1797|M.marinum_M               ---------------
MUL_2045|M.ulcerans_Agy99           ---------------
MAV_3766|M.avium_104                ---------------
MAB_3234|M.abscessus_ATCC_1997      ---------------
TH_2393|M.thermoresistible__bu      ---------------
MLBr_00691|M.leprae_Br4923          GLIMITRSLNRRPQH