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RKVMAVAAVLLTAATISGATASADTEMQPAGSVPIPDGPAQTWIVADLDTGQVLAGRDQNVTHPPASTIK VLLALVALDELNLNSTVVADEADTHVECNCVGVKAGHTYTARQLLDGLLLVSGNDAANTLAQLLGGQDAA VAKMNAKAAALGAMNTHAATPSGLDGPGGSGWSTAHDLAVIFRTAMANPVFAHITAEPSAMFPGEDGEHP IVNQDELLQRYPGAIGGKTGYTNAARKTFVGAAARNGRRLVIAMMYGLVKEGGPTYWDQAGSLFDWGFAL NPQSGIGSL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2045 | dacB | - | 100% (290) | D-alanyl-D-alanine carboxypeptidase DacB |
| M. ulcerans Agy99 | MUL_1445 | dacC | 5e-61 | 49.23% (260) | penicillin-binding protein DacC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2935 | dacB2 | 1e-137 | 83.51% (291) | D-alanyl-D-alanine carboxypeptidase |
| M. gilvum PYR-GCK | Mflv_4179 | - | 1e-108 | 66.32% (288) | Serine-type D-Ala-D-Ala carboxypeptidase |
| M. tuberculosis H37Rv | Rv2911 | dacB2 | 1e-137 | 83.51% (291) | D-alanyl-D-alanine carboxypeptidase |
| M. leprae Br4923 | MLBr_00691 | - | 2e-62 | 46.76% (278) | putative D-alanyl-D-alanine carboxypeptidase |
| M. abscessus ATCC 19977 | MAB_3234 | - | 1e-99 | 64.58% (288) | D-alanyl-D-alanine carboxypeptidase DacB |
| M. marinum M | MMAR_1797 | dacB | 1e-165 | 98.97% (290) | D-alanyl-D-alanine carboxypeptidase DacB |
| M. avium 104 | MAV_3766 | - | 1e-130 | 78.62% (290) | D-alanyl-D-alanine carboxypeptidase |
| M. smegmatis MC2 155 | MSMEG_2433 | - | 1e-108 | 65.85% (287) | D-alanyl-D-alanine carboxypeptidase |
| M. thermoresistible (build 8) | TH_2392 | - | 1e-105 | 64.81% (287) | D-alanyl-D-alanine carboxypeptidase |
| M. vanbaalenii PYR-1 | Mvan_2184 | - | 1e-109 | 66.78% (292) | Serine-type D-Ala-D-Ala carboxypeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2045|M.ulcerans_Agy99 -----------------------MRKVMAVAAVLLT-AATISGATASADT
MMAR_1797|M.marinum_M -----------------------MRKVMAVAAALLT-AATISGATASADT
Mb2935|M.bovis_AF2122/97 -----------------------MRKLMTATAALCACAVTVSAGAAWADA
Rv2911|M.tuberculosis_H37Rv -----------------------MRKLMTATAALCACAVTVSAGAAWADA
MAV_3766|M.avium_104 --------------MDRKLDFAAMRKLWTAAAALLL--VGACGAPTAAAD
Mflv_4179|M.gilvum_PYR-GCK MNTTGRAGRGWIDFPVMTRLLASLGAALCLILAGSGVVSPTASAVP-VTG
Mvan_2184|M.vanbaalenii_PYR-1 ----------------MTRLLACLGAVLCLVGS---VSVPHAAAVP-ATG
MSMEG_2433|M.smegmatis_MC2_155 ----------------MWRYA--FGLVVLVVSGLITGPGSLAVPVARADA
TH_2392|M.thermoresistible__bu ----------------MGRFAGAFALLLIAVLSVVAPGAPVTDPVAWADP
MAB_3234|M.abscessus_ATCC_1997 -------------------MSDPMSTLRIRALAVLSVLFLSTLPVGVARA
MLBr_00691|M.leprae_Br4923 --------------MSFLRSTACLAAAVFAIVGPVALDLPTAVPVGHAEP
: .
MUL_2045|M.ulcerans_Agy99 EMQP----------------------------------------------
MMAR_1797|M.marinum_M EMQP----------------------------------------------
Mb2935|M.bovis_AF2122/97 DVQP----------------------------------------------
Rv2911|M.tuberculosis_H37Rv DVQP----------------------------------------------
MAV_3766|M.avium_104 STQP----------------------------------------------
Mflv_4179|M.gilvum_PYR-GCK IVQP----------------------------------------------
Mvan_2184|M.vanbaalenii_PYR-1 IVQP----------------------------------------------
MSMEG_2433|M.smegmatis_MC2_155 DIQQ----------------------------------------------
TH_2392|M.thermoresistible__bu EIRP----------------------------------------------
MAB_3234|M.abscessus_ATCC_1997 DMA-----------------------------------------------
MLBr_00691|M.leprae_Br4923 NAGPNAGPATCPYQVSTPPAVDSSEVPQTGNPPMPLAVPPKPVGGAALNS
MUL_2045|M.ulcerans_Agy99 AGSVPIPDGP-------AQTWIVADLDTGQVLAGRDQNVTHPPASTIKVL
MMAR_1797|M.marinum_M AGSVPIPDGP-------AQTWIVADLDTGQVLAGRDQNVTHPPASTIKVL
Mb2935|M.bovis_AF2122/97 AGSVPIPDGP-------AQTWIVADLDSGQVLAGRDQNVAHPPASTIKVL
Rv2911|M.tuberculosis_H37Rv AGSVPIPDGP-------AQTWIVADLDSGQVLAGRDQNVAHPPASTIKVL
MAV_3766|M.avium_104 AGSIPIPDGP-------AQTWIIADLDSGQVLAGRDPNVAHPPASTIKTL
Mflv_4179|M.gilvum_PYR-GCK AGSVPVPDGP-------AQAWVLADMDTGAVLAARQENGRFAPASTIKIL
Mvan_2184|M.vanbaalenii_PYR-1 AGSMPIPDGP-------AQAWIVADMDTGAVLAARDEHGHFAPASTIKVL
MSMEG_2433|M.smegmatis_MC2_155 VGSVAPPEGP-------AETWVVADMDTGQILAGRGEYVRHAPASTIKTL
TH_2392|M.thermoresistible__bu VGSVPAPTGP-------AQAWIVADLDTGEVLAGRNENTRYAPASTIKTL
MAB_3234|M.abscessus_ATCC_1997 ---APPPEGP-------AQAWLVADLDSGQILAARDPYATHAPASTIKVL
MLBr_00691|M.leprae_Br4923 CGIVTAPDTPPVPGDLSAEAWLVADLNSGAVIAARDPHGRHRPASIIKVL
. * * *::*::**:::* ::*.* . *** ** *
MUL_2045|M.ulcerans_Agy99 LALVALDELNLNSTVVADEADTHVECNCVGVKAGHTYTARQLLDGLLLVS
MMAR_1797|M.marinum_M LALVALDELDLNSTVVADEADTHVECNCVGVKAGHTYTARQLLDGLLLVS
Mb2935|M.bovis_AF2122/97 LALVALDELDLNSTVVADVADTQAECNCVGVKPGRSYTARQLLDGLLLVS
Rv2911|M.tuberculosis_H37Rv LALVALDELDLNSTVVADVADTQAECNCVGVKPGRSYTARQLLDGLLLVS
MAV_3766|M.avium_104 LAQVVLDEVSLDATVVADAADTQVECNCVGIKPGRSYTARQLLDALLLVS
Mflv_4179|M.gilvum_PYR-GCK LAMVVLDELPLDATVVANEADTRVECNCAGVAPGTTYTTRQLLEGLLLVS
Mvan_2184|M.vanbaalenii_PYR-1 LAMVVLDELPLDATIVANEADTLVECNCAGVTPGRTYTTRQLLEALLLVS
MSMEG_2433|M.smegmatis_MC2_155 LALVVLDEVPLDSTIVADETDTDVECNCAGVAPGRTYTARQLLEAALLAS
TH_2392|M.thermoresistible__bu LAQVVLDEVPLDATIVATDEDTEVICNCAGVAPGHTYTTRQLLEGLLLAS
MAB_3234|M.abscessus_ATCC_1997 LALVALDEVPMDATVVADAADAKAECNCVGIKAGQTYTARELLDAALLES
MLBr_00691|M.leprae_Br4923 LAMASINTLNLNKSVAGTAEDAAAEGTKVGVHDGGTYTINQLLHGLLMQS
** . :: : :: ::.. *: . . .*: * :** .:**.. *: *
MUL_2045|M.ulcerans_Agy99 GNDAANTLAQLLGGQDAAVAKMNAKAAALGAMNTHAATPSGLDGPGGSGW
MMAR_1797|M.marinum_M GNDAANTLAQMLGGQDAAVAKMNAKAAALGAMNTHAATPSGLDGPGGSGW
Mb2935|M.bovis_AF2122/97 GNDAANTLAHMLGGQDVTVAKMNAKAATLGATSTHATTPSGLDGPGGSGA
Rv2911|M.tuberculosis_H37Rv GNDAANTLAHMLGGQDVTVAKMNAKAATLGATSTHATTPSGLDGPGGSGA
MAV_3766|M.avium_104 GNDAANTLAHMLGGPEATVAKMNAKAAALGATNTHASTPSGLDGPNGSGS
Mflv_4179|M.gilvum_PYR-GCK GNDAANTLATMLGGRDAAVAKMNAKAAGLGAHGTRAGSPSGIDGPGIDIW
Mvan_2184|M.vanbaalenii_PYR-1 GNDAANTLATMLGGRDVAVMKMNAKAATLGAYGTNAGSPSGIDGPGIDIW
MSMEG_2433|M.smegmatis_MC2_155 GNDAANTLARMLGGPEAAVAKMNAKAAQLGARDTNVVTPSGLDAPGMPFW
TH_2392|M.thermoresistible__bu GNDAANTLARMLGGEQAAVAKMNALAGRLGAHGTTVASTSGLDVPGVPFW
MAB_3234|M.abscessus_ATCC_1997 GNDAANTLAHLLGGRQATVDKMNAKAAALGATSTHTDSPSGLDAPGMDMR
MLBr_00691|M.leprae_Br4923 GNDAAHSLAMQLGGMQQALQKINVLAAKLGGQDTRVATPSGLDGPGMS--
*****::** *** : :: *:*. *. **. .* . :.**:* *.
MUL_2045|M.ulcerans_Agy99 STAHDLAVIFRTAMANPVFAHITAEPSAMFP--GEDGEHPIVNQDELLQR
MMAR_1797|M.marinum_M STAHDLAVIFRTAMANPVFAHITAEPSAMFP--GEDGEHPIVNQDELLQR
Mb2935|M.bovis_AF2122/97 STAHDLVVIFRAAMANPVFAQITAEPSAMFP--SDNGEQLIVNQDELLQR
Rv2911|M.tuberculosis_H37Rv STAHDLVVIFRAAMANPVFAQITAEPSAMFP--SDNGEQLIVNQDELLQR
MAV_3766|M.avium_104 STAHDLAVIFRAAMANPVFAQITAEPSAMFP--GDNGLQPITNQDELLQR
Mflv_4179|M.gilvum_PYR-GCK STPRDLAVLFRAAMAYPVFAQITAQPTAVFP--TKSGDVVLVNQDEMLHR
Mvan_2184|M.vanbaalenii_PYR-1 STPRDLAVIFRAAMADPVFAQIVAQPTAVFP--AKTGDVVLVNQDELLHR
MSMEG_2433|M.smegmatis_MC2_155 STPHDLAVIFRAAMADPVFAQITAMPSTVFP--AKTGDRVLVNQNELLHR
TH_2392|M.thermoresistible__bu STPHDLAVIFRAALNHPVFAEITAMPSAVFP--ARRGEMVLVNQNELLQR
MAB_3234|M.abscessus_ATCC_1997 TSPHDLAVIFRAALANPVFAEITAQPSAPFP--GRG----LHNQNELMYR
MLBr_00691|M.leprae_Br4923 TSAYDIGLFYRYAWQNPSFSNIVATRTFNFPGPGDHPGYQLENDNQLLYQ
::. *: :::* * * *:.*.* : ** : *::::: :
MUL_2045|M.ulcerans_Agy99 YPGAIGGKTGYTNAARKTFVGAAARNGRRLVIAMMYGLVKEGGPTYWDQA
MMAR_1797|M.marinum_M YPGAIGGKTGYTNAARKTFVGAAARNGRRLVIAMMYGLVKEGGPTYWDQA
Mb2935|M.bovis_AF2122/97 YPGAIGGKTGYTNAARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQA
Rv2911|M.tuberculosis_H37Rv YPGAIGGKTGYTNAARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQA
MAV_3766|M.avium_104 YPGAIGGKTGFTNAARKTFVGAAARGGRRLVIAMMYGLIKEGGPSYWDQA
Mflv_4179|M.gilvum_PYR-GCK YPGTFGGKTGYTDLARKTFVAGASRNGRHLVVAMMYGLVTEGGPTYWDQA
Mvan_2184|M.vanbaalenii_PYR-1 YPGTFGGKTGYTDLARKTFVGGAARNGRHLVVALMYGLVKEGGPTYWDQA
MSMEG_2433|M.smegmatis_MC2_155 YPGTLGGKTGFTDIARKTFVAAAQRDGRRLVIAMMYGLVKEGGPTYWDQA
TH_2392|M.thermoresistible__bu YPGALGGKTGYTDIARKTYVGAAQRDGRRLVVALMYGLVADGGPTYWDQA
MAB_3234|M.abscessus_ATCC_1997 YPGVIGGKTGFTDIARKTYVVAAERDGKRLVVSMMYGLVHEGGPTYWDQA
MLBr_00691|M.leprae_Br4923 YPGALGGKTGYTDDAGQTFVGAANRNGRRLMAVLLHGTRQPIAP--WEQA
***.:*****:*: * :*:* .* *.*::*: :::* .* *:**
MUL_2045|M.ulcerans_Agy99 GSLFDWGFALNPQSGIGSL-------------------------------
MMAR_1797|M.marinum_M GSLFDWGFALNPQSGIGSL-------------------------------
Mb2935|M.bovis_AF2122/97 ATLFDWGFALNPQASVGSL-------------------------------
Rv2911|M.tuberculosis_H37Rv ATLFDWGFALNPQASVGSL-------------------------------
MAV_3766|M.avium_104 ATLFDWGFAQSPQASIGSL-------------------------------
Mflv_4179|M.gilvum_PYR-GCK SALLDWGFALGPNAGVSRL-------------------------------
Mvan_2184|M.vanbaalenii_PYR-1 AALLDWGFALGPNSGVSRL-------------------------------
MSMEG_2433|M.smegmatis_MC2_155 AGLLDWGFAQDRSASIGAL-------------------------------
TH_2392|M.thermoresistible__bu TALLDWGFSQDTGTAIGVL-------------------------------
MAB_3234|M.abscessus_ATCC_1997 ASLFDWGFVNDGSSSVGSL-------------------------------
MLBr_00691|M.leprae_Br4923 AHLLDYGFSTAVGTQIGTLIEPDPTVAGNADRHGHGLQAAGIMSSNDTLP
*:*:** : :. *
MUL_2045|M.ulcerans_Agy99 -----------------------------
MMAR_1797|M.marinum_M -----------------------------
Mb2935|M.bovis_AF2122/97 -----------------------------
Rv2911|M.tuberculosis_H37Rv -----------------------------
MAV_3766|M.avium_104 -----------------------------
Mflv_4179|M.gilvum_PYR-GCK -----------------------------
Mvan_2184|M.vanbaalenii_PYR-1 -----------------------------
MSMEG_2433|M.smegmatis_MC2_155 -----------------------------
TH_2392|M.thermoresistible__bu -----------------------------
MAB_3234|M.abscessus_ATCC_1997 -----------------------------
MLBr_00691|M.leprae_Br4923 VRIGVAVVGTLIVFGLIMITRSLNRRPQH