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M. tuberculosis H37Rv Rv2911 (dacB2)

annotation: PROBABLE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACB2 (PENICILLIN-BINDING PROTEIN) (DD-PEPTIDASE) (DD-CARBOXYPEPTIDASE) (PBP) (DD-TRANSPEPTIDASE) (SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE) (D-AMINO ACID HYDROLASE)
coordinates: 3218339 - 3219214
length: 291

MRKLMTATAALCACAVTVSAGAAWADADVQPAGSVPIPDGPAQTWIVADLDSGQVLAGRDQNVAHPPAST
IKVLLALVALDELDLNSTVVADVADTQAECNCVGVKPGRSYTARQLLDGLLLVSGNDAANTLAHMLGGQD
VTVAKMNAKAATLGATSTHATTPSGLDGPGGSGASTAHDLVVIFRAAMANPVFAQITAEPSAMFPSDNGE
QLIVNQDELLQRYPGAIGGKTGYTNAARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQAATLFDWGF
ALNPQASVGSL

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv2911 dacB2 - 100% (291) PROBABLE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACB2 (PENICILLIN-BINDING PROTEIN) (DD-PEPTIDASE) (DD-CARBOXYPEPTIDASE) (PBP) (DD-TRANSPEPTIDASE) (SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE) (D-AMINO ACID HYDROLASE)
M. tuberculosis H37Rv Rv3330 dacB1 1e-58 45.07% (284) penicillin-binding protein DacB1

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2935 dacB2 1e-166 100.00% (291) D-alanyl-D-alanine carboxypeptidase
M. gilvum PYR-GCK Mflv_4179 - 1e-106 64.75% (295) Serine-type D-Ala-D-Ala carboxypeptidase
M. leprae Br4923 MLBr_00691 - 9e-59 45.62% (274) putative D-alanyl-D-alanine carboxypeptidase
M. abscessus ATCC 19977 MAB_3234 - 1e-100 65.82% (275) D-alanyl-D-alanine carboxypeptidase DacB
M. marinum M MMAR_1797 dacB 1e-138 84.19% (291) D-alanyl-D-alanine carboxypeptidase DacB
M. avium 104 MAV_3766 - 1e-137 83.22% (292) D-alanyl-D-alanine carboxypeptidase
M. smegmatis MC2 155 MSMEG_2433 - 1e-107 68.36% (275) D-alanyl-D-alanine carboxypeptidase
M. thermoresistible (build 8) TH_2392 - 1e-101 62.15% (288) D-alanyl-D-alanine carboxypeptidase
M. ulcerans Agy99 MUL_2045 dacB 1e-137 83.51% (291) D-alanyl-D-alanine carboxypeptidase DacB
M. vanbaalenii PYR-1 Mvan_2184 - 1e-108 66.67% (294) Serine-type D-Ala-D-Ala carboxypeptidase

CLUSTAL 2.0.9 multiple sequence alignment


Rv2911|M.tuberculosis_H37Rv         -----------------------MRKLMTATAALCACAVTVSAGAAWADA
Mb2935|M.bovis_AF2122/97            -----------------------MRKLMTATAALCACAVTVSAGAAWADA
MMAR_1797|M.marinum_M               -----------------------MRKVMAVAAALLT-AATISGATASADT
MUL_2045|M.ulcerans_Agy99           -----------------------MRKVMAVAAVLLT-AATISGATASADT
MAV_3766|M.avium_104                --------------MDRKLDFAAMRKLWTAAAALLL--VGACGAPTAAAD
Mflv_4179|M.gilvum_PYR-GCK          MNTTGRAGRGWIDFPVMTRLLASLGAALCLILAGSGVVSPTASAVP-VTG
Mvan_2184|M.vanbaalenii_PYR-1       ----------------MTRLLACLGAVLCLVGS---VSVPHAAAVP-ATG
MSMEG_2433|M.smegmatis_MC2_155      ----------------MWRYA--FGLVVLVVSGLITGPGSLAVPVARADA
TH_2392|M.thermoresistible__bu      ----------------MGRFAGAFALLLIAVLSVVAPGAPVTDPVAWADP
MAB_3234|M.abscessus_ATCC_1997      -------------------MSDPMSTLRIRALAVLSVLFLSTLPVGVARA
MLBr_00691|M.leprae_Br4923          --------------MSFLRSTACLAAAVFAIVGPVALDLPTAVPVGHAEP
                                                           :                       .  

Rv2911|M.tuberculosis_H37Rv         DVQP----------------------------------------------
Mb2935|M.bovis_AF2122/97            DVQP----------------------------------------------
MMAR_1797|M.marinum_M               EMQP----------------------------------------------
MUL_2045|M.ulcerans_Agy99           EMQP----------------------------------------------
MAV_3766|M.avium_104                STQP----------------------------------------------
Mflv_4179|M.gilvum_PYR-GCK          IVQP----------------------------------------------
Mvan_2184|M.vanbaalenii_PYR-1       IVQP----------------------------------------------
MSMEG_2433|M.smegmatis_MC2_155      DIQQ----------------------------------------------
TH_2392|M.thermoresistible__bu      EIRP----------------------------------------------
MAB_3234|M.abscessus_ATCC_1997      DMA-----------------------------------------------
MLBr_00691|M.leprae_Br4923          NAGPNAGPATCPYQVSTPPAVDSSEVPQTGNPPMPLAVPPKPVGGAALNS
                                                                                      

Rv2911|M.tuberculosis_H37Rv         AGSVPIPDGP-------AQTWIVADLDSGQVLAGRDQNVAHPPASTIKVL
Mb2935|M.bovis_AF2122/97            AGSVPIPDGP-------AQTWIVADLDSGQVLAGRDQNVAHPPASTIKVL
MMAR_1797|M.marinum_M               AGSVPIPDGP-------AQTWIVADLDTGQVLAGRDQNVTHPPASTIKVL
MUL_2045|M.ulcerans_Agy99           AGSVPIPDGP-------AQTWIVADLDTGQVLAGRDQNVTHPPASTIKVL
MAV_3766|M.avium_104                AGSIPIPDGP-------AQTWIIADLDSGQVLAGRDPNVAHPPASTIKTL
Mflv_4179|M.gilvum_PYR-GCK          AGSVPVPDGP-------AQAWVLADMDTGAVLAARQENGRFAPASTIKIL
Mvan_2184|M.vanbaalenii_PYR-1       AGSMPIPDGP-------AQAWIVADMDTGAVLAARDEHGHFAPASTIKVL
MSMEG_2433|M.smegmatis_MC2_155      VGSVAPPEGP-------AETWVVADMDTGQILAGRGEYVRHAPASTIKTL
TH_2392|M.thermoresistible__bu      VGSVPAPTGP-------AQAWIVADLDTGEVLAGRNENTRYAPASTIKTL
MAB_3234|M.abscessus_ATCC_1997      ---APPPEGP-------AQAWLVADLDSGQILAARDPYATHAPASTIKVL
MLBr_00691|M.leprae_Br4923          CGIVTAPDTPPVPGDLSAEAWLVADLNSGAVIAARDPHGRHRPASIIKVL
                                        . *  *       *::*::**:::* ::*.*     . *** ** *

Rv2911|M.tuberculosis_H37Rv         LALVALDELDLNSTVVADVADTQAECNCVGVKPGRSYTARQLLDGLLLVS
Mb2935|M.bovis_AF2122/97            LALVALDELDLNSTVVADVADTQAECNCVGVKPGRSYTARQLLDGLLLVS
MMAR_1797|M.marinum_M               LALVALDELDLNSTVVADEADTHVECNCVGVKAGHTYTARQLLDGLLLVS
MUL_2045|M.ulcerans_Agy99           LALVALDELNLNSTVVADEADTHVECNCVGVKAGHTYTARQLLDGLLLVS
MAV_3766|M.avium_104                LAQVVLDEVSLDATVVADAADTQVECNCVGIKPGRSYTARQLLDALLLVS
Mflv_4179|M.gilvum_PYR-GCK          LAMVVLDELPLDATVVANEADTRVECNCAGVAPGTTYTTRQLLEGLLLVS
Mvan_2184|M.vanbaalenii_PYR-1       LAMVVLDELPLDATIVANEADTLVECNCAGVTPGRTYTTRQLLEALLLVS
MSMEG_2433|M.smegmatis_MC2_155      LALVVLDEVPLDSTIVADETDTDVECNCAGVAPGRTYTARQLLEAALLAS
TH_2392|M.thermoresistible__bu      LAQVVLDEVPLDATIVATDEDTEVICNCAGVAPGHTYTTRQLLEGLLLAS
MAB_3234|M.abscessus_ATCC_1997      LALVALDEVPMDATVVADAADAKAECNCVGIKAGQTYTARELLDAALLES
MLBr_00691|M.leprae_Br4923          LAMASINTLNLNKSVAGTAEDAAAEGTKVGVHDGGTYTINQLLHGLLMQS
                                    ** . :: : :: ::..   *: .  . .*:  * :** .:**.. *: *

Rv2911|M.tuberculosis_H37Rv         GNDAANTLAHMLGGQDVTVAKMNAKAATLGATSTHATTPSGLDGPGGSGA
Mb2935|M.bovis_AF2122/97            GNDAANTLAHMLGGQDVTVAKMNAKAATLGATSTHATTPSGLDGPGGSGA
MMAR_1797|M.marinum_M               GNDAANTLAQMLGGQDAAVAKMNAKAAALGAMNTHAATPSGLDGPGGSGW
MUL_2045|M.ulcerans_Agy99           GNDAANTLAQLLGGQDAAVAKMNAKAAALGAMNTHAATPSGLDGPGGSGW
MAV_3766|M.avium_104                GNDAANTLAHMLGGPEATVAKMNAKAAALGATNTHASTPSGLDGPNGSGS
Mflv_4179|M.gilvum_PYR-GCK          GNDAANTLATMLGGRDAAVAKMNAKAAGLGAHGTRAGSPSGIDGPGIDIW
Mvan_2184|M.vanbaalenii_PYR-1       GNDAANTLATMLGGRDVAVMKMNAKAATLGAYGTNAGSPSGIDGPGIDIW
MSMEG_2433|M.smegmatis_MC2_155      GNDAANTLARMLGGPEAAVAKMNAKAAQLGARDTNVVTPSGLDAPGMPFW
TH_2392|M.thermoresistible__bu      GNDAANTLARMLGGEQAAVAKMNALAGRLGAHGTTVASTSGLDVPGVPFW
MAB_3234|M.abscessus_ATCC_1997      GNDAANTLAHLLGGRQATVDKMNAKAAALGATSTHTDSPSGLDAPGMDMR
MLBr_00691|M.leprae_Br4923          GNDAAHSLAMQLGGMQQALQKINVLAAKLGGQDTRVATPSGLDGPGMS--
                                    *****::**  *** : :: *:*. *. **. .* . :.**:* *.    

Rv2911|M.tuberculosis_H37Rv         STAHDLVVIFRAAMANPVFAQITAEPSAMFP--SDNGEQLIVNQDELLQR
Mb2935|M.bovis_AF2122/97            STAHDLVVIFRAAMANPVFAQITAEPSAMFP--SDNGEQLIVNQDELLQR
MMAR_1797|M.marinum_M               STAHDLAVIFRTAMANPVFAHITAEPSAMFP--GEDGEHPIVNQDELLQR
MUL_2045|M.ulcerans_Agy99           STAHDLAVIFRTAMANPVFAHITAEPSAMFP--GEDGEHPIVNQDELLQR
MAV_3766|M.avium_104                STAHDLAVIFRAAMANPVFAQITAEPSAMFP--GDNGLQPITNQDELLQR
Mflv_4179|M.gilvum_PYR-GCK          STPRDLAVLFRAAMAYPVFAQITAQPTAVFP--TKSGDVVLVNQDEMLHR
Mvan_2184|M.vanbaalenii_PYR-1       STPRDLAVIFRAAMADPVFAQIVAQPTAVFP--AKTGDVVLVNQDELLHR
MSMEG_2433|M.smegmatis_MC2_155      STPHDLAVIFRAAMADPVFAQITAMPSTVFP--AKTGDRVLVNQNELLHR
TH_2392|M.thermoresistible__bu      STPHDLAVIFRAALNHPVFAEITAMPSAVFP--ARRGEMVLVNQNELLQR
MAB_3234|M.abscessus_ATCC_1997      TSPHDLAVIFRAALANPVFAEITAQPSAPFP--GRG----LHNQNELMYR
MLBr_00691|M.leprae_Br4923          TSAYDIGLFYRYAWQNPSFSNIVATRTFNFPGPGDHPGYQLENDNQLLYQ
                                    ::. *: :::* *   * *:.*.*  :  **         : *::::: :

Rv2911|M.tuberculosis_H37Rv         YPGAIGGKTGYTNAARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQA
Mb2935|M.bovis_AF2122/97            YPGAIGGKTGYTNAARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQA
MMAR_1797|M.marinum_M               YPGAIGGKTGYTNAARKTFVGAAARNGRRLVIAMMYGLVKEGGPTYWDQA
MUL_2045|M.ulcerans_Agy99           YPGAIGGKTGYTNAARKTFVGAAARNGRRLVIAMMYGLVKEGGPTYWDQA
MAV_3766|M.avium_104                YPGAIGGKTGFTNAARKTFVGAAARGGRRLVIAMMYGLIKEGGPSYWDQA
Mflv_4179|M.gilvum_PYR-GCK          YPGTFGGKTGYTDLARKTFVAGASRNGRHLVVAMMYGLVTEGGPTYWDQA
Mvan_2184|M.vanbaalenii_PYR-1       YPGTFGGKTGYTDLARKTFVGGAARNGRHLVVALMYGLVKEGGPTYWDQA
MSMEG_2433|M.smegmatis_MC2_155      YPGTLGGKTGFTDIARKTFVAAAQRDGRRLVIAMMYGLVKEGGPTYWDQA
TH_2392|M.thermoresistible__bu      YPGALGGKTGYTDIARKTYVGAAQRDGRRLVVALMYGLVADGGPTYWDQA
MAB_3234|M.abscessus_ATCC_1997      YPGVIGGKTGFTDIARKTYVVAAERDGKRLVVSMMYGLVHEGGPTYWDQA
MLBr_00691|M.leprae_Br4923          YPGALGGKTGYTDDAGQTFVGAANRNGRRLMAVLLHGTRQPIAP--WEQA
                                    ***.:*****:*: * :*:* .* *.*::*:  :::*     .*  *:**

Rv2911|M.tuberculosis_H37Rv         ATLFDWGFALNPQASVGSL-------------------------------
Mb2935|M.bovis_AF2122/97            ATLFDWGFALNPQASVGSL-------------------------------
MMAR_1797|M.marinum_M               GSLFDWGFALNPQSGIGSL-------------------------------
MUL_2045|M.ulcerans_Agy99           GSLFDWGFALNPQSGIGSL-------------------------------
MAV_3766|M.avium_104                ATLFDWGFAQSPQASIGSL-------------------------------
Mflv_4179|M.gilvum_PYR-GCK          SALLDWGFALGPNAGVSRL-------------------------------
Mvan_2184|M.vanbaalenii_PYR-1       AALLDWGFALGPNSGVSRL-------------------------------
MSMEG_2433|M.smegmatis_MC2_155      AGLLDWGFAQDRSASIGAL-------------------------------
TH_2392|M.thermoresistible__bu      TALLDWGFSQDTGTAIGVL-------------------------------
MAB_3234|M.abscessus_ATCC_1997      ASLFDWGFVNDGSSSVGSL-------------------------------
MLBr_00691|M.leprae_Br4923          AHLLDYGFSTAVGTQIGTLIEPDPTVAGNADRHGHGLQAAGIMSSNDTLP
                                      *:*:**     : :. *                               

Rv2911|M.tuberculosis_H37Rv         -----------------------------
Mb2935|M.bovis_AF2122/97            -----------------------------
MMAR_1797|M.marinum_M               -----------------------------
MUL_2045|M.ulcerans_Agy99           -----------------------------
MAV_3766|M.avium_104                -----------------------------
Mflv_4179|M.gilvum_PYR-GCK          -----------------------------
Mvan_2184|M.vanbaalenii_PYR-1       -----------------------------
MSMEG_2433|M.smegmatis_MC2_155      -----------------------------
TH_2392|M.thermoresistible__bu      -----------------------------
MAB_3234|M.abscessus_ATCC_1997      -----------------------------
MLBr_00691|M.leprae_Br4923          VRIGVAVVGTLIVFGLIMITRSLNRRPQH

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv2911	dacB2	-	100% (291)	PROBABLE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACB2 (PENICILLIN-BINDING PROTEIN) (DD-PEPTIDASE) (DD-CARBOXYPEPTIDASE) (PBP) (DD-TRANSPEPTIDASE) (SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE) (D-AMINO ACID HYDROLASE)
M. tuberculosis H37Rv	Rv3330	dacB1	1e-58	45.07% (284)	penicillin-binding protein DacB1