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M. thermoresistible (build 8) TH_1977 (-)

annotation: PROBABLE PENICILLIN-BINDING PROTEIN DACB1 (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE) (DD-PEPTIDASE) (DD-CARBOXYPEPTIDASE) (PBP) (DD-TRANSPEPTIDASE) (SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE) (D-AMINO ACID HYDROLASE)
coordinates: 3829850 - 3831085
length: 412

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_1977 - - 100% (412) PROBABLE PENICILLIN-BINDING PROTEIN DACB1 (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE) (DD-PEPTIDASE) (DD-CARBOXYPEPTIDASE) (PBP) (DD-TRANSPEPTIDASE) (SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE) (D-AMINO ACID HYDROLASE)
M. thermoresistible (build 8) TH_2392 - 8e-63 48.47% (262) D-alanyl-D-alanine carboxypeptidase
M. thermoresistible (build 8) TH_2393 - 1e-55 47.72% (241) D-alanyl-D-alanine carboxypeptidase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3363 dacB1 1e-151 67.51% (394) penicillin-binding protein DacB1
M. gilvum PYR-GCK Mflv_4869 - 1e-158 69.42% (399) Serine-type D-Ala-D-Ala carboxypeptidase
M. tuberculosis H37Rv Rv3330 dacB1 1e-151 67.51% (394) penicillin-binding protein DacB1
M. leprae Br4923 MLBr_00691 - 1e-144 62.41% (415) putative D-alanyl-D-alanine carboxypeptidase
M. abscessus ATCC 19977 MAB_3681 - 1e-134 59.23% (417) penicillin-binding protein DacB1
M. marinum M MMAR_1192 dacC 1e-148 64.93% (402) penicillin-binding protein DacC
M. avium 104 MAV_4305 - 1e-152 65.48% (420) D-alanyl-D-alanine carboxypeptidase
M. smegmatis MC2 155 MSMEG_1661 - 1e-161 69.65% (402) D-alanyl-D-alanine carboxypeptidase
M. ulcerans Agy99 MUL_1445 dacC 1e-148 64.93% (402) penicillin-binding protein DacC
M. vanbaalenii PYR-1 Mvan_1562 - 1e-163 69.63% (405) Serine-type D-Ala-D-Ala carboxypeptidase

CLUSTAL 2.0.9 multiple sequence alignment


TH_1977|M.thermoresistible__bu      ------MAIFSSVTRRLVAVGAAIAVLAMPAISSLPTAAADPVAEA----
MSMEG_1661|M.smegmatis_MC2_155      ------------MTRRAVTAVGALALLTAPLMT-----AGVAGAEP----
Mflv_4869|M.gilvum_PYR-GCK          ----------MATLRTTLLRASALVTASMLALAP---AAAAQPAPA----
Mvan_1562|M.vanbaalenii_PYR-1       ----------MATLRTLLTRSSALVTAAMLILAP---VAAAQPPAE----
MLBr_00691|M.leprae_Br4923          ------MS----FLRSTACLAAAVFAIVGPVALDLPTAVPVGHAEPNAGP
MAV_4305|M.avium_104                ------MSTSGALVRSASCLAAALFLAAAPAVSG--TASPLGRAEPGAEP
Mb3363|M.bovis_AF2122/97            ------MA----FLRSVSCLAAAVFA------VGTGIGLPTAAGEPNAAP
Rv3330|M.tuberculosis_H37Rv         ------MA----FLRSVSCLAAAVFA------VGTGIGLPTAAGEPNAAP
MMAR_1192|M.marinum_M               ------MY----LLRAASCLAAAVFMAAGPAVVGMPAALPSASAEPNAEA
MUL_1445|M.ulcerans_Agy99           ------MY----LLRAASCLAAAVFMAAGPAVVGMPAALPSASAEPNAEA
MAB_3681|M.abscessus_ATCC_1997      MTTWTPAPDRRPSPRTAVTRLAAATAAGLIVAVLPLCAPPLASAEPGFTP
                                                  *      .*                           

TH_1977|M.thermoresistible__bu      ---GDPCPYRETTPPAISASEVPKPGEDPPAPLPVPATAVGGDALSGCGV
MSMEG_1661|M.smegmatis_MC2_155      ---GVDCPYRETTPPAVDASEVPKPGEAAPGPLPVPPKAIGGEALSGCGV
Mflv_4869|M.gilvum_PYR-GCK          ---ADPCPYRVTTPPAVDASEVPKPGDPTPGPLPVPAKPMGGDALSGCGV
Mvan_1562|M.vanbaalenii_PYR-1       ---ANTCPYRVTTPPAVDASEVPKPGDPTPGPLPVPAKPMGGDALSGCGV
MLBr_00691|M.leprae_Br4923          NAGPATCPYQVSTPPAVDSSEVPQTGN-PPMPLAVPPKPVGGAALNSCGI
MAV_4305|M.avium_104                NAAPTNCPYKVNTPPAVDSSEVPTAGD-PPMPLAVPAKPVGGDALGSCGI
Mb3363|M.bovis_AF2122/97            ----AACPYKVSTPPAVDSSEVPAAGE-PPLPLVVPPTPVGGNALGGCGI
Rv3330|M.tuberculosis_H37Rv         ----AACPYKVSTPPAVDSSEVPAAGE-PPLPLVVPPTPVGGNALGGCGI
MMAR_1192|M.marinum_M               NSGAQECPYRVTTPPAVDSSEVPQAGE-PPLPLAVPSAPVGGNALGGCGI
MUL_1445|M.ulcerans_Agy99           NSGAQECPYRVTTPPAVDSSEVPQAGE-PPLPLAVPSAPVGGNALGGCGI
MAB_3681|M.abscessus_ATCC_1997      -PDTSGCPYKVVTPPAVDTSEVPKAGGDPPAPLPVPAKPIGGEMLGRCDV
                                          ***:  ****:.:**** .*  .* ** **. .:**  *. *.:

TH_1977|M.thermoresistible__bu      IVAPGTPPLPTEISAEAWLVADLDTGDVIAAKDPHGRHRPASVIKALTAM
MSMEG_1661|M.smegmatis_MC2_155      ITAPNTPPVPEDVSAEAWIVADMDTGDVIAARDPHGRHRPASIIKVLTAT
Mflv_4869|M.gilvum_PYR-GCK          ITAPGTPPVPGDVSAEAWLVADLDSGDVIAARDPHGRHRPASIIKVLTAM
Mvan_1562|M.vanbaalenii_PYR-1       ITAPGTPPVPADVSAEAWLVADLDSGDVIAARDPHGRHRPASIIKVLTAM
MLBr_00691|M.leprae_Br4923          VTAPDTPPVPGDLSAEAWLVADLNSGAVIAARDPHGRHRPASIIKVLLAM
MAV_4305|M.avium_104                VAAPNTPPLPGDVSAEAWLVADLDSGAVIAAKDPHGRHRPASIIKVLVAM
Mb3363|M.bovis_AF2122/97            ITAPGSAPAPGDVSAEAWLVADLDSGAVIAARDPHGRHRPASVIKVLVAM
Rv3330|M.tuberculosis_H37Rv         ITAPGSAPAPGDVSAEAWLVADLDSGAVIAARDPHGRHRPASVIKVLVAM
MMAR_1192|M.marinum_M               IAAPDTPPVPGDVSAEAWLVGDLDSGAIIAARDPHARHRPASIIKVLVAM
MUL_1445|M.ulcerans_Agy99           IAAPDTPPVPGDVSAEAWLVGDLDSGAIIAARDPHGRHRPASIIKVLVVM
MAB_3681|M.abscessus_ATCC_1997      ITPDGAGPVPNDISAESWLIADLNTGNVVAAKDPHARHRPASVIKVLVAM
                                    :.. .: * * ::***:*::.*:::* ::**:***.******:**.* . 

TH_1977|M.thermoresistible__bu      AAINELPLNRQVHGTAQDSAIEGTKVGVGPGGVYTVRDLLHGLMMYSGND
MSMEG_1661|M.smegmatis_MC2_155      AALNELNLNKRVAGTQDDANAEGTRVGVGPGGQYTINDLLHGLLMYSGND
Mflv_4869|M.gilvum_PYR-GCK          QALRDLPLMKTVPGTPEDAAQEGTKVGVGEGGVYTVNDLLHGLLMYSGND
Mvan_1562|M.vanbaalenii_PYR-1       QAINDLPLHKVIPGTEEDAAQEGTKVGVGPGGFYSINDLLHGLLMYSGND
MLBr_00691|M.leprae_Br4923          ASINTLNLNKSVAGTAEDAAAEGTKVGVHDGGTYTINQLLHGLLMQSGND
MAV_4305|M.avium_104                AAINTLNLNKAVPGTADDAAAEGTKVGVEEGGVFTVNQLLHGLLMHSGND
Mb3363|M.bovis_AF2122/97            ASINTLTLNKSVAGTADDAAVEGTKVGVNTGGTYTVNQLLHGLLMHSGND
Rv3330|M.tuberculosis_H37Rv         ASINTLTLNKSVAGTADDAAVEGTKVGVNTGGTYTVNQLLHGLLMHSGND
MMAR_1192|M.marinum_M               VSIKELNQNKAVPGTNDDSAAEGTKVGVNAGGMYTVNQLLHGLLMHSGND
MUL_1445|M.ulcerans_Agy99           VSIKELNQNKAVPGTNDDSAAEGTKVGVNAGGMYTVNQLLHGLLMHSGND
MAB_3681|M.abscessus_ATCC_1997      EAINNLNLNQAVVGTQEDANSEGTRVGVDVGGTYTVRQLLTGLLMNSGND
                                     ::. *   : : ** :*:  ***:***  ** :::.:** **:* ****

TH_1977|M.thermoresistible__bu      AANALANQMGGVDVALDKLNALAAKLGAQDTRAASPSGLDGPGMSTSAYD
MSMEG_1661|M.smegmatis_MC2_155      AAHALAMQLGGWDPALQKLNTLAAKLGGRDTRAATPSGLDGPGMSTSAYD
Mflv_4869|M.gilvum_PYR-GCK          AAHALAMQMGGMDTALNKINVLAQKLGARDTRVATPSGLDGPGMSTSVYD
Mvan_1562|M.vanbaalenii_PYR-1       AAHALAMQMGGMQTALNKINALAGKLGARDTRVATPSGLDGPGMSTSAYD
MLBr_00691|M.leprae_Br4923          AAHSLAMQLGGMQQALQKINVLAAKLGGQDTRVATPSGLDGPGMSTSAYD
MAV_4305|M.avium_104                AAHALAMQLGGMQQALEKINVLAAKLGGQDTRVATPSGLDAPGMSTSAYD
Mb3363|M.bovis_AF2122/97            AAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGLDGPGMSTSAYD
Rv3330|M.tuberculosis_H37Rv         AAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGLDGPGMSTSAYD
MMAR_1192|M.marinum_M               AAHALAIQLGGMQTALEKINMLAAKLGGRDTRVATPSGLDGPGMSTSAYD
MUL_1445|M.ulcerans_Agy99           AAHALAIQLGGMQTALEKINMLAAKLGGRDTRVATPSGLDGPGMSTSAYD
MAB_3681|M.abscessus_ATCC_1997      AAHALAVQLGGMDETVAKINDMAQKLGARDTRAATPSGLDGPGMSTSAYD
                                    ** :** *:**   :: *:* :* ***.:***.*:*****.******.**

TH_1977|M.thermoresistible__bu      IALIYRYAWQDPTFSQIVATRSYHFPGR-------EGSPPYEILNDNQLL
MSMEG_1661|M.smegmatis_MC2_155      IALFYRYAWQNPVFADIVHTQSYQFPGR-------DGGS-YPIENDNKLL
Mflv_4869|M.gilvum_PYR-GCK          MGLFYRYAWHNPVFADIVATRATQFPGR-------EGAG-YPIENDNKLL
Mvan_1562|M.vanbaalenii_PYR-1       IGLFYRYAWQNPVFTDIVATRSSNFPGR-------DGAG-YPIENDNKLL
MLBr_00691|M.leprae_Br4923          IGLFYRYAWQNPSFSNIVATRTFNFPGP-------GDHPGYQLENDNQLL
MAV_4305|M.avium_104                IGLFYRYAWQNPTFADIVATRTFDFPGH-------GDHPGYELENDNQLL
Mb3363|M.bovis_AF2122/97            IGLFYRYAWQNPVFADIVATRTFDFPGH-------GDHPGYELENDNQLL
Rv3330|M.tuberculosis_H37Rv         IGLFYRYAWQNPVFADIVATRTFDFPGH-------GDHPGYELENDNQLL
MMAR_1192|M.marinum_M               IGLFYRYAWQNPIFADIVATRTFDFPGH-------GEHPGYELENDNHLL
MUL_1445|M.ulcerans_Agy99           IGLFYRYAWQNPIFADIVATRTFDFPGH-------GEHPGYELENDNHLL
MAB_3681|M.abscessus_ATCC_1997      LGLFYKYAFADPTFADLVSAPKATFPGHPAKPGERDDHPAYEMTNDNKLL
                                    :.*:*:**: :* *:::* :    ***             * : ***:**

TH_1977|M.thermoresistible__bu      MNYPGALGGKTGFTDDAGQTFVGAAERDGRRLVAVLLRGTRQPIPPWQQA
MSMEG_1661|M.smegmatis_MC2_155      ANYPGALGGKTGYTDDAGQTFVGAAERDGRRLIAVLLKGTRVPIAPWEQA
Mflv_4869|M.gilvum_PYR-GCK          ANYPGALGGKTGYTDDAGQTFVGAAERDGRRLVAVLMRGTRQPIAPWEQA
Mvan_1562|M.vanbaalenii_PYR-1       ANYPGALGGKTGFTDDAGQTFVGAATRDGRRLVAVLLRGTRQPIAPWEQA
MLBr_00691|M.leprae_Br4923          YQYPGALGGKTGYTDDAGQTFVGAANRNGRRLMAVLLHGTRQPIAPWEQA
MAV_4305|M.avium_104                YKYPGALGGKTGYTDDAGQTFVGAANHDGRRLVAVLLHGTRQPIAPWEQA
Mb3363|M.bovis_AF2122/97            YNYPGALGGKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQA
Rv3330|M.tuberculosis_H37Rv         YNYPGALGGKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQA
MMAR_1192|M.marinum_M               YNYPGALGGKTGYTDDAGQTFVGAANHNGRRLFAVLLHGTRQPIAPWEQA
MUL_1445|M.ulcerans_Agy99           YNYPGALGGKTGYTDDAGQTFVGAANHNGRRLFAVLLHGTRQPIAPWEQA
MAB_3681|M.abscessus_ATCC_1997      YNYPGALGGKTGYTDDAQQTFVGAAERDGRRLVVTMLRGTRLPIAPWEQA
                                     :**********:**** ******* ::****...:::*** **.**:**

TH_1977|M.thermoresistible__bu      AQLLDYGFATAPGTRVGTLVDPDPSVSRQKINTSGEADTAA----APILL
MSMEG_1661|M.smegmatis_MC2_155      ARLLDYGFATPPGTKVGTLVDPDPSLAPKQAEEP--SPAQA----ASVLP
Mflv_4869|M.gilvum_PYR-GCK          ARLLDYGFATAPGTKVGTLIEPDPSLGVDRADPAVAALTKTNANANAVLP
Mvan_1562|M.vanbaalenii_PYR-1       ARLLDYGFATAPGTKVGSLIEPDPSLGVTRADPAAATTTT----ANAVLP
MLBr_00691|M.leprae_Br4923          AHLLDYGFSTAVGTQIGTLIEPDPTVA-----GNADRHGHG-LQAAGIMS
MAV_4305|M.avium_104                AHLLDYGFATPQGTQVGSLIAPDPSLAPAKRDGAADRLAGN-TAAAGMIS
Mb3363|M.bovis_AF2122/97            AHLLDYGFNTPAGTQIGTLIEPDPSLMSTDR-NPADRQRVD-PQAAARIS
Rv3330|M.tuberculosis_H37Rv         AHLLDYGFNTPAGTQIGTLIEPDPSLMSTDR-NPADRQRVD-PQAAARIS
MMAR_1192|M.marinum_M               AHLLDYGFSTAQGTQIGSLIEPDPSLVAPKE-TPEARRLAD-AQAAGLVS
MUL_1445|M.ulcerans_Agy99           AHLLDYGFSTAQGTQIGSLIEPDPSLVAPKE-TPEARRLAD-AQAAGLVS
MAB_3681|M.abscessus_ATCC_1997      AHLLDYGFSTPRDASIGKLVDPDPSLLTKPHADDTPSAQAA----GLPAE
                                    *:****** *. .: :*.*: ***::                        

TH_1977|M.thermoresistible__bu      PADAVPVRVGVAVIGTIIVFGLIMAARSMNRRSHR-
MSMEG_1661|M.smegmatis_MC2_155      PADAMPVRVGVAVVGAIIVFMLILGARQLNQRPQH-
Mflv_4869|M.gilvum_PYR-GCK          DVDAMPVRIGVGVIGAVIVLTLIMGARALNSRPAR-
Mvan_1562|M.vanbaalenii_PYR-1       DVDAMPVRIGVGVIGAVIVFSLIMGARALNRRPAR-
MLBr_00691|M.leprae_Br4923          SNDTLPVRIGVAVVGTLIVFGLIMITRSLNRRPQH-
MAV_4305|M.avium_104                SADALPVRVGVAVIGTIVVFTLIMMARSMNRRPQHR
Mb3363|M.bovis_AF2122/97            AADALPVRVGVAVIGALIVFGLIMVARAMNRRPQH-
Rv3330|M.tuberculosis_H37Rv         AADALPVRVGVAVIGALIVFGLIMVARAMNRRPQH-
MMAR_1192|M.marinum_M               SADALPVRVGVAVIGAIIVFGLMLVARSLNNRPQH-
MUL_1445|M.ulcerans_Agy99           SADALPVRVGVAVIGAIIVFGLMLVARSLNNRPQH-
MAB_3681|M.abscessus_ATCC_1997      AINSVPVRVGVTIIGAMIVFGLILAARSLNRRQA--
                                      :::***:** ::*:::*: *:: :* :* *

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_1977	-	-	100% (412)	PROBABLE PENICILLIN-BINDING PROTEIN DACB1 (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE) (DD-PEPTIDASE) (DD-CARBOXYPEPTIDASE) (PBP) (DD-TRANSPEPTIDASE) (SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE) (D-AMINO ACID HYDROLASE)
M. thermoresistible (build 8)	TH_2392	-	8e-63	48.47% (262)	D-alanyl-D-alanine carboxypeptidase
M. thermoresistible (build 8)	TH_2393	-	1e-55	47.72% (241)	D-alanyl-D-alanine carboxypeptidase