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M. thermoresistible (build 8) TH_2145 ()

annotation: PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN
coordinates: 4220976 - 4221827
length: 284

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2145-100% (284)PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN
M. thermoresistible (build 8)TH_1018-1e-0529.93% (147) PROBABLE INTEGRAL MEMBRANE PROTEIN

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0114-3e-8262.92% (240) integral membrane protein
M. gilvum PYR-GCKMflv_1071-4e-9161.76% (272) rhomboid family protein
M. tuberculosis H37RvRv0110-3e-8262.92% (240) integral membrane protein
M. leprae Br4923MLBr_01171-6e-0729.73% (148) hypothetical protein MLBr_01171
M. abscessus ATCC 19977MAB_0026-6e-4643.04% (237) rhomboid family protein
M. marinum MMMAR_0300-1e-10063.67% (289) serine protease
M. avium 104MAV_1554-2e-0528.67% (150) rhomboid family protein
M. smegmatis MC2 155MSMEG_5036-5e-8063.93% (244) rhomboid family protein
M. ulcerans Agy99MUL_4822-3e-8463.60% (250) serine protease
M. vanbaalenii PYR-1Mvan_5753-2e-8859.64% (280) rhomboid family protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1071|M.gilvum_PYR-GCK          MSSPYP--YPAQQIPTCYRHPDRQTYVRCTRCNRFICPECMRDAAVGHQC
Mvan_5753|M.vanbaalenii_PYR-1       MTYPYPPGAPYQQVPTCFRHPDRQTYVRCTRCNRFICPECMHDAAVGHQC
Mb0114|M.bovis_AF2122/97            ----------------------------------------MRVGPVGHQC
Rv0110|M.tuberculosis_H37Rv         ----------------------------------------MRVGPVGHQC
MMAR_0300|M.marinum_M               MSGPSA-PESPA----CYRHPGRPTYVRCTRCDRYICGDCMRSGAVGHQC
MUL_4822|M.ulcerans_Agy99           ----------------------------------------MRSGAVGHQC
MSMEG_5036|M.smegmatis_MC2_155      ----------------------------------------MRTAAVGHQC
TH_2145|M.thermoresistible__bu      MSMPST-PHVPAGTPTCYRHPDRTTYVRCTRCGRYICPECMRAAAVGHQC
MAB_0026|M.abscessus_ATCC_1997      -----MAHPGQVPVYGCAWHPDRATAVRCVRCGRPVCPACMRSAPVGQQC
MLBr_01171|M.leprae_Br4923          ----------------------------------------MGAPSACGGG
MAV_1554|M.avium_104                ----------------------------------------MG--------
                                                                            *         

Mflv_1071|M.gilvum_PYR-GCK          IDCVGEGMRSVRPVK---------TLTPVVTYALIGINLLAFALQMASPG
Mvan_5753|M.vanbaalenii_PYR-1       PDCVGEGARSVRPVTNAVGARPARSTTPVVTYALIGLNLLMFALQMASPD
Mb0114|M.bovis_AF2122/97            AECVREGARAVRQPRTPFGGR-QRSATPVVTYTLISLNALVFVMQVTVMG
Rv0110|M.tuberculosis_H37Rv         AECVREGARAVRQPRTPFGGR-QRSATPVVTYTLISLNALVFVMQVTVMG
MMAR_0300|M.marinum_M               VECVRADARTVRQPRTQFGGR-QRSVTPVVTFSLIAVSVLVFVLQLVVAG
MUL_4822|M.ulcerans_Agy99           VECVRADARTVRQPRTQFGGR-QRSVTPVVTFSLIAVSVLVFVLQLVVAG
MSMEG_5036|M.smegmatis_MC2_155      VDCVNAAARTVPEPRTRFGGK-VREGAPVLTYTLIAVNVLMFVLQIAGGD
TH_2145|M.thermoresistible__bu      VECVAAAARTVRRPTTPFGGR-ISTGPPVLTYTLIAVNVLMYVLQRASTG
MAB_0026|M.abscessus_ATCC_1997      VECVQQGAKSVRQVKPLQQVR------AWITWALIAVNVLVYTATVSDGV
MLBr_01171|M.leprae_Br4923          SALMTLPEKNLGYKPETETNR--RLRWMVGGVTILTFMALLYLVELIDQL
MAV_1554|M.avium_104                --------KTTGRAPAAQTKK--RSTAVAGATTIVTFVALLYLVELIDQL
                                            :                       ::: .  * :        

Mflv_1071|M.gilvum_PYR-GCK          --------LQRAFGLWSPAVADG-EMYRLLTSAFLHFGLTHLAFNMLALY
Mvan_5753|M.vanbaalenii_PYR-1       --------LDRALGLWPPAAADG-ELYRLLTSAFLHFSVTHIAFNMLALY
Mb0114|M.bovis_AF2122/97            --------LERQLALWPPAVASG-QTYRLVTSAFLHYGAMHLLLNMWALY
Rv0110|M.tuberculosis_H37Rv         --------LERQLALWPPAVASG-QTYRLVTSAFLHYGAMHLLLNMWALY
MMAR_0300|M.marinum_M               --------LGPHLALWPPAVADG-QLYRLVTSAFMHYGTLHLVFNMWALY
MUL_4822|M.ulcerans_Agy99           --------LGPHLALWPPAVADG-QLYRLVTSAFMHYGRLHLVFNMWALY
MSMEG_5036|M.smegmatis_MC2_155      --------LESRLTLWPPALALHDEYYRLVTSMFLHYGAMHLLFNMWALY
TH_2145|M.thermoresistible__bu      --------FTEAFVLWAPAVAAG-EYYRLVTSAFLHFGLMHLLFNMFALY
MAB_0026|M.abscessus_ATCC_1997      GGDVTGSQLFRELVLYLPWVAQG-ELWRTVTTGFLHLGLMHIAVNMLSLA
MLBr_01171|M.leprae_Br4923          --------TRHSLDNNGIRLLKTDVLWGISFAPVLHANWQHLVANTIPLL
MAV_1554|M.avium_104                --------TRHALDVHGIRPQRLDGLWGILFAPVLHESWQHLMANTVPLL
                                                :             :    : .:* .  *:  *  .* 

Mflv_1071|M.gilvum_PYR-GCK          FVGPPLEAALGRARFITLYLVSALGGSVLVYLLT-LNA-----LTAGASG
Mvan_5753|M.vanbaalenii_PYR-1       FVGAPLEFALGRLRFVALYLFSALGGSVLVYLLT-FNA-----LTAGASG
Mb0114|M.bovis_AF2122/97            VVGPPLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNT-----ATAGASG
Rv0110|M.tuberculosis_H37Rv         VVGPPLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNT-----ATAGASG
MMAR_0300|M.marinum_M               IVGPPLEMWLGRLRFGGLYALSALGGSVLVYLIAPLNT-----ATAGASG
MUL_4822|M.ulcerans_Agy99           VVGPPLEMWLGRLRFGGLYALSALGGSVLVYLIAPLNT-----ATAGASG
MSMEG_5036|M.smegmatis_MC2_155      VVGPPLEKWLGLTRFGVLYALSGLGGSVLVYMLSPLNS-----ATAGASG
TH_2145|M.thermoresistible__bu      VIGGPLEAALGRLRFGLLYALSALGGSVLVYLLA-MN------PTAGASG
MAB_0026|M.abscessus_ATCC_1997      MIGPGLERAFGGQRYAAIYGTALLGSSAAAMWLS-PNA-----VVAGASG
MLBr_01171|M.leprae_Br4923          VLG-FLIALAGLSRFIWVTAMVWIFGGSATWLIGNMGSSFGPTDHIGVSG
MAV_1554|M.avium_104                VLG-FLMTLAGLARFVWATVIIWIVGGFGTWLIGNVGSSCGPTDHIGASG
                                    .:*  *    *  *:        : ..  .  :   .         *.**

Mflv_1071|M.gilvum_PYR-GCK          AVFGLFGATFVVGRKLNMDVRSVMAIIVLNLAFTFLIPLFTSQ----NIS
Mvan_5753|M.vanbaalenii_PYR-1       AVFGLFGATFVVGKRLNMDVRSVVMIIGLNLAFTFLIPLFTSQ----NIS
Mb0114|M.bovis_AF2122/97            AVFGLFGATFMVARRLHLDVRWVVALIVINLAFTFLAPAI---------S
Rv0110|M.tuberculosis_H37Rv         AVFGLFGATFMVARRLHLDVRWVVALIVINLAFTFLAPAI---------S
MMAR_0300|M.marinum_M               AIFGLFGATFVVAKRLNLDIRWVVALIAINLAITFVAPAVGSQ----LIS
MUL_4822|M.ulcerans_Agy99           AIFGLFGATFVVAKRLNLDIRWVVALIAINLAITFVAPAVGSQ----LIS
MSMEG_5036|M.smegmatis_MC2_155      AIFGLFGAIFVVARHLNLDVRAIGVIVVINLVFTFVGPALG-T----AIS
TH_2145|M.thermoresistible__bu      AVFGLFAATYVVAKRLNLDVRFVTGLIVVNLVITFVVPGI---------S
MAB_0026|M.abscessus_ATCC_1997      AIYGLLGAALVLSLRERLNPQTIIIVLLLNIGLSISLPGIS---------
MLBr_01171|M.leprae_Br4923          LIFGWLAFLLVFGLFVRRGWD-IIGCMVLFAYGGVLLGVMPVLGRCGGVS
MAV_1554|M.avium_104                LIFGWLAFLLVFGIFVRRVRDIIIGLAVMFAYGGVLLGAMPVLGLCGGVS
                                     ::* :.   :..   .     :     :     .    .          

Mflv_1071|M.gilvum_PYR-GCK          WQGHIGGLVTGALVAAAFAYAPRAQRTLIQAGAVGAILVVFVGLIVWRTA
Mvan_5753|M.vanbaalenii_PYR-1       WQGHIGGLVTGAVVAAAFVYAPRQQRNLVQAGAAVALLVLFVALVAWRTV
Mb0114|M.bovis_AF2122/97            WQGHVGGLVTGALVAATYVYAPRERRNLIQATVTITVLVAFVVLIGWRTV
Rv0110|M.tuberculosis_H37Rv         WQGHVGGLVTGALVAATYVYAPRERRNLIQATVTITVLVAFVVLIGWRTV
MMAR_0300|M.marinum_M               WQGHVGGLITGALVAAAYVYAPRERRNFIQGAVTLTVAVAFVVLIWWRTS
MUL_4822|M.ulcerans_Agy99           WQGHVGGLITGALVAAAYVYAPRERRNFIQGAVTLTVAVAFVVLIWWRTS
MSMEG_5036|M.smegmatis_MC2_155      WQGHIGGLVTGALVASAFVYAPRERRTATAAGVTVAFAMLFAALIFWRTD
TH_2145|M.thermoresistible__bu      WQGHLGGLLTGALVAAAFAYPPPARRNAVQAATVVTLVLLFAVLIWVRTD
MAB_0026|M.abscessus_ATCC_1997      LAGHMGGLLFGVLSAGALLYYREVCRGIGMPDLARKASTPWVLAAVVAAL
MLBr_01171|M.leprae_Br4923          WQGHLCGAISGVVAAYLLSAPERKTRALKEAGTDSPRLKT----------
MAV_1554|M.avium_104                WQGHLCGAIAGVLAAYLLSEPERKGRSGRKTGAVAPRPKT----------
                                      **: * : *.: *          *                        

Mflv_1071|M.gilvum_PYR-GCK          ELRTLMGLG-----
Mvan_5753|M.vanbaalenii_PYR-1       ELRTMLGLG-----
Mb0114|M.bovis_AF2122/97            DLLALFGGRLNLS-
Rv0110|M.tuberculosis_H37Rv         DLLALFGGRLNLS-
MMAR_0300|M.marinum_M               ELLAMFGGHLNLG-
MUL_4822|M.ulcerans_Agy99           ELLAMFGGHLNLG-
MSMEG_5036|M.smegmatis_MC2_155      RLLFLLGAG-----
TH_2145|M.thermoresistible__bu      VLLATWMTHF----
MAB_0026|M.abscessus_ATCC_1997      SVALIMAKVLAYAG
MLBr_01171|M.leprae_Br4923          --------------
MAV_1554|M.avium_104                --------------