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TYPYPPGAPYQQVPTCFRHPDRQTYVRCTRCNRFICPECMHDAAVGHQCPDCVGEGARSVRPVTNAVGAR PARSTTPVVTYALIGLNLLMFALQMASPDLDRALGLWPPAAADGELYRLLTSAFLHFSVTHIAFNMLALY FVGAPLEFALGRLRFVALYLFSALGGSVLVYLLTFNALTAGASGAVFGLFGATFVVGKRLNMDVRSVVMI IGLNLAFTFLIPLFTSQNISWQGHIGGLVTGAVVAAAFVYAPRQQRNLVQAGAAVALLVLFVALVAWRTV ELRTMLGLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5753 | - | - | 100% (290) | rhomboid family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0114 | - | 3e-80 | 61.04% (249) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_1071 | - | 1e-130 | 78.97% (290) | rhomboid family protein |
| M. tuberculosis H37Rv | Rv0110 | - | 3e-80 | 61.04% (249) | integral membrane protein |
| M. leprae Br4923 | MLBr_01171 | - | 4e-06 | 25.65% (230) | hypothetical protein MLBr_01171 |
| M. abscessus ATCC 19977 | MAB_0026 | - | 2e-46 | 40.16% (249) | rhomboid family protein |
| M. marinum M | MMAR_0300 | - | 6e-95 | 59.72% (283) | serine protease |
| M. avium 104 | MAV_1554 | - | 3e-05 | 25.73% (206) | rhomboid family protein |
| M. smegmatis MC2 155 | MSMEG_5036 | - | 4e-72 | 56.75% (252) | rhomboid family protein |
| M. thermoresistible (build 8) | TH_2145 | - | 1e-88 | 59.64% (280) | PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_4822 | - | 6e-80 | 59.44% (249) | serine protease |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5753|M.vanbaalenii_PYR-1 MTYPYPPGAPYQQVPTCFRHPDRQTYVRCTRCNRFICPECMHDAAVGHQC
Mflv_1071|M.gilvum_PYR-GCK MSSPYP--YPAQQIPTCYRHPDRQTYVRCTRCNRFICPECMRDAAVGHQC
Mb0114|M.bovis_AF2122/97 ----------------------------------------MRVGPVGHQC
Rv0110|M.tuberculosis_H37Rv ----------------------------------------MRVGPVGHQC
MMAR_0300|M.marinum_M MSGPSA-PESPA----CYRHPGRPTYVRCTRCDRYICGDCMRSGAVGHQC
MUL_4822|M.ulcerans_Agy99 ----------------------------------------MRSGAVGHQC
MSMEG_5036|M.smegmatis_MC2_155 ----------------------------------------MRTAAVGHQC
TH_2145|M.thermoresistible__bu MSMPST-PHVPAGTPTCYRHPDRTTYVRCTRCGRYICPECMRAAAVGHQC
MAB_0026|M.abscessus_ATCC_1997 -----MAHPGQVPVYGCAWHPDRATAVRCVRCGRPVCPACMRSAPVGQQC
MLBr_01171|M.leprae_Br4923 ----------------------------------------MGAPSACGGG
MAV_1554|M.avium_104 ----------------------------------------MG--------
*
Mvan_5753|M.vanbaalenii_PYR-1 PDCVGEGARSVRPVTNAVGARPARSTTPVVTYALIGLNLLMFALQMASPD
Mflv_1071|M.gilvum_PYR-GCK IDCVGEGMRSVRPVK---------TLTPVVTYALIGINLLAFALQMASPG
Mb0114|M.bovis_AF2122/97 AECVREGARAVRQPRTPFGGR-QRSATPVVTYTLISLNALVFVMQVTVMG
Rv0110|M.tuberculosis_H37Rv AECVREGARAVRQPRTPFGGR-QRSATPVVTYTLISLNALVFVMQVTVMG
MMAR_0300|M.marinum_M VECVRADARTVRQPRTQFGGR-QRSVTPVVTFSLIAVSVLVFVLQLVVAG
MUL_4822|M.ulcerans_Agy99 VECVRADARTVRQPRTQFGGR-QRSVTPVVTFSLIAVSVLVFVLQLVVAG
MSMEG_5036|M.smegmatis_MC2_155 VDCVNAAARTVPEPRTRFGGK-VREGAPVLTYTLIAVNVLMFVLQIAGGD
TH_2145|M.thermoresistible__bu VECVAAAARTVRRPTTPFGGR-ISTGPPVLTYTLIAVNVLMYVLQRASTG
MAB_0026|M.abscessus_ATCC_1997 VECVQQGAKSVRQVKPLQQVR------AWITWALIAVNVLVYTATVSDGV
MLBr_01171|M.leprae_Br4923 SALMTLPEKNLGYKPETETNR--RLRWMVGGVTILTFMALLYLVELIDQL
MAV_1554|M.avium_104 --------KTTGRAPAAQTKK--RSTAVAGATTIVTFVALLYLVELIDQL
: ::: . * :
Mvan_5753|M.vanbaalenii_PYR-1 --------LDRALGLWPPAAADG-ELYRLLTSAFLHFSVTHIAFNMLALY
Mflv_1071|M.gilvum_PYR-GCK --------LQRAFGLWSPAVADG-EMYRLLTSAFLHFGLTHLAFNMLALY
Mb0114|M.bovis_AF2122/97 --------LERQLALWPPAVASG-QTYRLVTSAFLHYGAMHLLLNMWALY
Rv0110|M.tuberculosis_H37Rv --------LERQLALWPPAVASG-QTYRLVTSAFLHYGAMHLLLNMWALY
MMAR_0300|M.marinum_M --------LGPHLALWPPAVADG-QLYRLVTSAFMHYGTLHLVFNMWALY
MUL_4822|M.ulcerans_Agy99 --------LGPHLALWPPAVADG-QLYRLVTSAFMHYGRLHLVFNMWALY
MSMEG_5036|M.smegmatis_MC2_155 --------LESRLTLWPPALALHDEYYRLVTSMFLHYGAMHLLFNMWALY
TH_2145|M.thermoresistible__bu --------FTEAFVLWAPAVAAG-EYYRLVTSAFLHFGLMHLLFNMFALY
MAB_0026|M.abscessus_ATCC_1997 GGDVTGSQLFRELVLYLPWVAQG-ELWRTVTTGFLHLGLMHIAVNMLSLA
MLBr_01171|M.leprae_Br4923 --------TRHSLDNNGIRLLKTDVLWGISFAPVLHANWQHLVANTIPLL
MAV_1554|M.avium_104 --------TRHALDVHGIRPQRLDGLWGILFAPVLHESWQHLMANTVPLL
: : : .:* . *: * .*
Mvan_5753|M.vanbaalenii_PYR-1 FVGAPLEFALGRLRFVALYLFSALGGSVLVYLLT-FNA-----LTAGASG
Mflv_1071|M.gilvum_PYR-GCK FVGPPLEAALGRARFITLYLVSALGGSVLVYLLT-LNA-----LTAGASG
Mb0114|M.bovis_AF2122/97 VVGPPLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNT-----ATAGASG
Rv0110|M.tuberculosis_H37Rv VVGPPLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNT-----ATAGASG
MMAR_0300|M.marinum_M IVGPPLEMWLGRLRFGGLYALSALGGSVLVYLIAPLNT-----ATAGASG
MUL_4822|M.ulcerans_Agy99 VVGPPLEMWLGRLRFGGLYALSALGGSVLVYLIAPLNT-----ATAGASG
MSMEG_5036|M.smegmatis_MC2_155 VVGPPLEKWLGLTRFGVLYALSGLGGSVLVYMLSPLNS-----ATAGASG
TH_2145|M.thermoresistible__bu VIGGPLEAALGRLRFGLLYALSALGGSVLVYLLA-MN------PTAGASG
MAB_0026|M.abscessus_ATCC_1997 MIGPGLERAFGGQRYAAIYGTALLGSSAAAMWLS-PNA-----VVAGASG
MLBr_01171|M.leprae_Br4923 VLG-FLIALAGLSRFIWVTAMVWIFGGSATWLIGNMGSSFGPTDHIGVSG
MAV_1554|M.avium_104 VLG-FLMTLAGLARFVWATVIIWIVGGFGTWLIGNVGSSCGPTDHIGASG
.:* * * *: : .. . : . *.**
Mvan_5753|M.vanbaalenii_PYR-1 AVFGLFGATFVVGKRLNMDVRSVVMIIGLNLAFTFLIPLFTSQ----NIS
Mflv_1071|M.gilvum_PYR-GCK AVFGLFGATFVVGRKLNMDVRSVMAIIVLNLAFTFLIPLFTSQ----NIS
Mb0114|M.bovis_AF2122/97 AVFGLFGATFMVARRLHLDVRWVVALIVINLAFTFLAPAI---------S
Rv0110|M.tuberculosis_H37Rv AVFGLFGATFMVARRLHLDVRWVVALIVINLAFTFLAPAI---------S
MMAR_0300|M.marinum_M AIFGLFGATFVVAKRLNLDIRWVVALIAINLAITFVAPAVGSQ----LIS
MUL_4822|M.ulcerans_Agy99 AIFGLFGATFVVAKRLNLDIRWVVALIAINLAITFVAPAVGSQ----LIS
MSMEG_5036|M.smegmatis_MC2_155 AIFGLFGAIFVVARHLNLDVRAIGVIVVINLVFTFVGPALG-T----AIS
TH_2145|M.thermoresistible__bu AVFGLFAATYVVAKRLNLDVRFVTGLIVVNLVITFVVPGI---------S
MAB_0026|M.abscessus_ATCC_1997 AIYGLLGAALVLSLRERLNPQTIIIVLLLNIGLSISLPGIS---------
MLBr_01171|M.leprae_Br4923 LIFGWLAFLLVFGLFVRRGWD-IIGCMVLFAYGGVLLGVMPVLGRCGGVS
MAV_1554|M.avium_104 LIFGWLAFLLVFGIFVRRVRDIIIGLAVMFAYGGVLLGAMPVLGLCGGVS
::* :. :.. . : : . .
Mvan_5753|M.vanbaalenii_PYR-1 WQGHIGGLVTGAVVAAAFVYAPRQQRNLVQAGAAVALLVLFVALVAWRTV
Mflv_1071|M.gilvum_PYR-GCK WQGHIGGLVTGALVAAAFAYAPRAQRTLIQAGAVGAILVVFVGLIVWRTA
Mb0114|M.bovis_AF2122/97 WQGHVGGLVTGALVAATYVYAPRERRNLIQATVTITVLVAFVVLIGWRTV
Rv0110|M.tuberculosis_H37Rv WQGHVGGLVTGALVAATYVYAPRERRNLIQATVTITVLVAFVVLIGWRTV
MMAR_0300|M.marinum_M WQGHVGGLITGALVAAAYVYAPRERRNFIQGAVTLTVAVAFVVLIWWRTS
MUL_4822|M.ulcerans_Agy99 WQGHVGGLITGALVAAAYVYAPRERRNFIQGAVTLTVAVAFVVLIWWRTS
MSMEG_5036|M.smegmatis_MC2_155 WQGHIGGLVTGALVASAFVYAPRERRTATAAGVTVAFAMLFAALIFWRTD
TH_2145|M.thermoresistible__bu WQGHLGGLLTGALVAAAFAYPPPARRNAVQAATVVTLVLLFAVLIWVRTD
MAB_0026|M.abscessus_ATCC_1997 LAGHMGGLLFGVLSAGALLYYREVCRGIGMPDLARKASTPWVLAAVVAAL
MLBr_01171|M.leprae_Br4923 WQGHLCGAISGVVAAYLLSAPERKTRALKEAGTDSPRLKT----------
MAV_1554|M.avium_104 WQGHLCGAIAGVLAAYLLSEPERKGRSGRKTGAVAPRPKT----------
**: * : *.: * *
Mvan_5753|M.vanbaalenii_PYR-1 ELRTMLGLG-----
Mflv_1071|M.gilvum_PYR-GCK ELRTLMGLG-----
Mb0114|M.bovis_AF2122/97 DLLALFGGRLNLS-
Rv0110|M.tuberculosis_H37Rv DLLALFGGRLNLS-
MMAR_0300|M.marinum_M ELLAMFGGHLNLG-
MUL_4822|M.ulcerans_Agy99 ELLAMFGGHLNLG-
MSMEG_5036|M.smegmatis_MC2_155 RLLFLLGAG-----
TH_2145|M.thermoresistible__bu VLLATWMTHF----
MAB_0026|M.abscessus_ATCC_1997 SVALIMAKVLAYAG
MLBr_01171|M.leprae_Br4923 --------------
MAV_1554|M.avium_104 --------------