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RTAAVGHQCVDCVNAAARTVPEPRTRFGGKVREGAPVLTYTLIAVNVLMFVLQIAGGDLESRLTLWPPAL ALHDEYYRLVTSMFLHYGAMHLLFNMWALYVVGPPLEKWLGLTRFGVLYALSGLGGSVLVYMLSPLNSAT AGASGAIFGLFGAIFVVARHLNLDVRAIGVIVVINLVFTFVGPALGTAISWQGHIGGLVTGALVASAFVY APRERRTATAAGVTVAFAMLFAALIFWRTDRLLFLLGAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5036 | - | - | 100% (250) | rhomboid family protein |
| M. smegmatis MC2 155 | MSMEG_4904 | - | 5e-06 | 28.50% (193) | rhomboid family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0114 | - | 2e-88 | 64.11% (248) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_1071 | - | 2e-71 | 56.97% (251) | rhomboid family protein |
| M. tuberculosis H37Rv | Rv0110 | - | 2e-88 | 64.11% (248) | integral membrane protein |
| M. leprae Br4923 | MLBr_01171 | - | 2e-07 | 29.58% (142) | hypothetical protein MLBr_01171 |
| M. abscessus ATCC 19977 | MAB_0026 | - | 2e-31 | 37.44% (219) | rhomboid family protein |
| M. marinum M | MMAR_0300 | - | 7e-91 | 64.26% (249) | serine protease |
| M. avium 104 | MAV_1554 | - | 6e-07 | 25.93% (162) | rhomboid family protein |
| M. thermoresistible (build 8) | TH_2145 | - | 3e-80 | 63.93% (244) | PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_4822 | - | 5e-91 | 64.66% (249) | serine protease |
| M. vanbaalenii PYR-1 | Mvan_5753 | - | 3e-72 | 56.75% (252) | rhomboid family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1071|M.gilvum_PYR-GCK MSSPYP--YPAQQIPTCYRHPDRQTYVRCTRCNRFICPECMRDAAVGHQC
Mvan_5753|M.vanbaalenii_PYR-1 MTYPYPPGAPYQQVPTCFRHPDRQTYVRCTRCNRFICPECMHDAAVGHQC
Mb0114|M.bovis_AF2122/97 ----------------------------------------MRVGPVGHQC
Rv0110|M.tuberculosis_H37Rv ----------------------------------------MRVGPVGHQC
MMAR_0300|M.marinum_M MSGPSA-PESPA----CYRHPGRPTYVRCTRCDRYICGDCMRSGAVGHQC
MUL_4822|M.ulcerans_Agy99 ----------------------------------------MRSGAVGHQC
MSMEG_5036|M.smegmatis_MC2_155 ----------------------------------------MRTAAVGHQC
TH_2145|M.thermoresistible__bu MSMPST-PHVPAGTPTCYRHPDRTTYVRCTRCGRYICPECMRAAAVGHQC
MAB_0026|M.abscessus_ATCC_1997 -----MAHPGQVPVYGCAWHPDRATAVRCVRCGRPVCPACMRSAPVGQQC
MLBr_01171|M.leprae_Br4923 ----------------------------------------MGAPSACGGG
MAV_1554|M.avium_104 ----------------------------------------MG--------
*
Mflv_1071|M.gilvum_PYR-GCK IDCVGEGMRSVRPVK---------TLTPVVTYALIGINLLAFALQMASPG
Mvan_5753|M.vanbaalenii_PYR-1 PDCVGEGARSVRPVTNAVGARPARSTTPVVTYALIGLNLLMFALQMASPD
Mb0114|M.bovis_AF2122/97 AECVREGARAVRQPRTPFGGR-QRSATPVVTYTLISLNALVFVMQVTVMG
Rv0110|M.tuberculosis_H37Rv AECVREGARAVRQPRTPFGGR-QRSATPVVTYTLISLNALVFVMQVTVMG
MMAR_0300|M.marinum_M VECVRADARTVRQPRTQFGGR-QRSVTPVVTFSLIAVSVLVFVLQLVVAG
MUL_4822|M.ulcerans_Agy99 VECVRADARTVRQPRTQFGGR-QRSVTPVVTFSLIAVSVLVFVLQLVVAG
MSMEG_5036|M.smegmatis_MC2_155 VDCVNAAARTVPEPRTRFGGK-VREGAPVLTYTLIAVNVLMFVLQIAGGD
TH_2145|M.thermoresistible__bu VECVAAAARTVRRPTTPFGGR-ISTGPPVLTYTLIAVNVLMYVLQRASTG
MAB_0026|M.abscessus_ATCC_1997 VECVQQGAKSVRQVKPLQQVR------AWITWALIAVNVLVYTATVSDGV
MLBr_01171|M.leprae_Br4923 SALMTLPEKNLGYKPETETNR--RLRWMVGGVTILTFMALLYLVELIDQL
MAV_1554|M.avium_104 --------KTTGRAPAAQTKK--RSTAVAGATTIVTFVALLYLVELIDQL
: ::: . * :
Mflv_1071|M.gilvum_PYR-GCK --------LQRAFGLWSPAVADG-EMYRLLTSAFLHFGLTHLAFNMLALY
Mvan_5753|M.vanbaalenii_PYR-1 --------LDRALGLWPPAAADG-ELYRLLTSAFLHFSVTHIAFNMLALY
Mb0114|M.bovis_AF2122/97 --------LERQLALWPPAVASG-QTYRLVTSAFLHYGAMHLLLNMWALY
Rv0110|M.tuberculosis_H37Rv --------LERQLALWPPAVASG-QTYRLVTSAFLHYGAMHLLLNMWALY
MMAR_0300|M.marinum_M --------LGPHLALWPPAVADG-QLYRLVTSAFMHYGTLHLVFNMWALY
MUL_4822|M.ulcerans_Agy99 --------LGPHLALWPPAVADG-QLYRLVTSAFMHYGRLHLVFNMWALY
MSMEG_5036|M.smegmatis_MC2_155 --------LESRLTLWPPALALHDEYYRLVTSMFLHYGAMHLLFNMWALY
TH_2145|M.thermoresistible__bu --------FTEAFVLWAPAVAAG-EYYRLVTSAFLHFGLMHLLFNMFALY
MAB_0026|M.abscessus_ATCC_1997 GGDVTGSQLFRELVLYLPWVAQG-ELWRTVTTGFLHLGLMHIAVNMLSLA
MLBr_01171|M.leprae_Br4923 --------TRHSLDNNGIRLLKTDVLWGISFAPVLHANWQHLVANTIPLL
MAV_1554|M.avium_104 --------TRHALDVHGIRPQRLDGLWGILFAPVLHESWQHLMANTVPLL
: : : .:* . *: * .*
Mflv_1071|M.gilvum_PYR-GCK FVGPPLEAALGRARFITLYLVSALGGSVLVYLLT-LNA-----LTAGASG
Mvan_5753|M.vanbaalenii_PYR-1 FVGAPLEFALGRLRFVALYLFSALGGSVLVYLLT-FNA-----LTAGASG
Mb0114|M.bovis_AF2122/97 VVGPPLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNT-----ATAGASG
Rv0110|M.tuberculosis_H37Rv VVGPPLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNT-----ATAGASG
MMAR_0300|M.marinum_M IVGPPLEMWLGRLRFGGLYALSALGGSVLVYLIAPLNT-----ATAGASG
MUL_4822|M.ulcerans_Agy99 VVGPPLEMWLGRLRFGGLYALSALGGSVLVYLIAPLNT-----ATAGASG
MSMEG_5036|M.smegmatis_MC2_155 VVGPPLEKWLGLTRFGVLYALSGLGGSVLVYMLSPLNS-----ATAGASG
TH_2145|M.thermoresistible__bu VIGGPLEAALGRLRFGLLYALSALGGSVLVYLLA-MN------PTAGASG
MAB_0026|M.abscessus_ATCC_1997 MIGPGLERAFGGQRYAAIYGTALLGSSAAAMWLS-PNA-----VVAGASG
MLBr_01171|M.leprae_Br4923 VLG-FLIALAGLSRFIWVTAMVWIFGGSATWLIGNMGSSFGPTDHIGVSG
MAV_1554|M.avium_104 VLG-FLMTLAGLARFVWATVIIWIVGGFGTWLIGNVGSSCGPTDHIGASG
.:* * * *: : .. . : . *.**
Mflv_1071|M.gilvum_PYR-GCK AVFGLFGATFVVGRKLNMDVRSVMAIIVLNLAFTFLIPLFTSQ----NIS
Mvan_5753|M.vanbaalenii_PYR-1 AVFGLFGATFVVGKRLNMDVRSVVMIIGLNLAFTFLIPLFTSQ----NIS
Mb0114|M.bovis_AF2122/97 AVFGLFGATFMVARRLHLDVRWVVALIVINLAFTFLAPAI---------S
Rv0110|M.tuberculosis_H37Rv AVFGLFGATFMVARRLHLDVRWVVALIVINLAFTFLAPAI---------S
MMAR_0300|M.marinum_M AIFGLFGATFVVAKRLNLDIRWVVALIAINLAITFVAPAVGSQ----LIS
MUL_4822|M.ulcerans_Agy99 AIFGLFGATFVVAKRLNLDIRWVVALIAINLAITFVAPAVGSQ----LIS
MSMEG_5036|M.smegmatis_MC2_155 AIFGLFGAIFVVARHLNLDVRAIGVIVVINLVFTFVGPALG-T----AIS
TH_2145|M.thermoresistible__bu AVFGLFAATYVVAKRLNLDVRFVTGLIVVNLVITFVVPGI---------S
MAB_0026|M.abscessus_ATCC_1997 AIYGLLGAALVLSLRERLNPQTIIIVLLLNIGLSISLPGIS---------
MLBr_01171|M.leprae_Br4923 LIFGWLAFLLVFGLFVRRGWD-IIGCMVLFAYGGVLLGVMPVLGRCGGVS
MAV_1554|M.avium_104 LIFGWLAFLLVFGIFVRRVRDIIIGLAVMFAYGGVLLGAMPVLGLCGGVS
::* :. :.. . : : . .
Mflv_1071|M.gilvum_PYR-GCK WQGHIGGLVTGALVAAAFAYAPRAQRTLIQAGAVGAILVVFVGLIVWRTA
Mvan_5753|M.vanbaalenii_PYR-1 WQGHIGGLVTGAVVAAAFVYAPRQQRNLVQAGAAVALLVLFVALVAWRTV
Mb0114|M.bovis_AF2122/97 WQGHVGGLVTGALVAATYVYAPRERRNLIQATVTITVLVAFVVLIGWRTV
Rv0110|M.tuberculosis_H37Rv WQGHVGGLVTGALVAATYVYAPRERRNLIQATVTITVLVAFVVLIGWRTV
MMAR_0300|M.marinum_M WQGHVGGLITGALVAAAYVYAPRERRNFIQGAVTLTVAVAFVVLIWWRTS
MUL_4822|M.ulcerans_Agy99 WQGHVGGLITGALVAAAYVYAPRERRNFIQGAVTLTVAVAFVVLIWWRTS
MSMEG_5036|M.smegmatis_MC2_155 WQGHIGGLVTGALVASAFVYAPRERRTATAAGVTVAFAMLFAALIFWRTD
TH_2145|M.thermoresistible__bu WQGHLGGLLTGALVAAAFAYPPPARRNAVQAATVVTLVLLFAVLIWVRTD
MAB_0026|M.abscessus_ATCC_1997 LAGHMGGLLFGVLSAGALLYYREVCRGIGMPDLARKASTPWVLAAVVAAL
MLBr_01171|M.leprae_Br4923 WQGHLCGAISGVVAAYLLSAPERKTRALKEAGTDSPRLKT----------
MAV_1554|M.avium_104 WQGHLCGAIAGVLAAYLLSEPERKGRSGRKTGAVAPRPKT----------
**: * : *.: * *
Mflv_1071|M.gilvum_PYR-GCK ELRTLMGLG-----
Mvan_5753|M.vanbaalenii_PYR-1 ELRTMLGLG-----
Mb0114|M.bovis_AF2122/97 DLLALFGGRLNLS-
Rv0110|M.tuberculosis_H37Rv DLLALFGGRLNLS-
MMAR_0300|M.marinum_M ELLAMFGGHLNLG-
MUL_4822|M.ulcerans_Agy99 ELLAMFGGHLNLG-
MSMEG_5036|M.smegmatis_MC2_155 RLLFLLGAG-----
TH_2145|M.thermoresistible__bu VLLATWMTHF----
MAB_0026|M.abscessus_ATCC_1997 SVALIMAKVLAYAG
MLBr_01171|M.leprae_Br4923 --------------
MAV_1554|M.avium_104 --------------