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M. thermoresistible (build 8) TH_1873 ()

annotation: POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II)
coordinates: 3659869 - 3660585
length: 239

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1873-100% (239)POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II)
M. thermoresistible (build 8)TH_1503-1e-1431.46% (178) CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_1234-1e-1429.22% (219) metallo-beta-lactamase family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0651c-1e-11581.55% (233) glyoxalase II
M. gilvum PYR-GCKMflv_5123-1e-12083.97% (237) beta-lactamase domain-containing protein
M. tuberculosis H37RvRv0634c-1e-11581.55% (233) glyoxalase II
M. leprae Br4923MLBr_01912-1e-11278.81% (236) putative glyoxylase II
M. abscessus ATCC 19977MAB_4755c-8e-1530.94% (181) hypothetical protein MAB_4755c
M. marinum MMMAR_0965gloB1e-11883.12% (237) glyoxalase II, GloB
M. avium 104MAV_4532-1e-11883.54% (237) metallo-beta-lactamase family protein
M. smegmatis MC2 155MSMEG_1334-1e-11883.76% (234) metallo-beta-lactamase family protein
M. ulcerans Agy99MUL_0715gloB1e-11782.70% (237) glyoxalase II, GloB
M. vanbaalenii PYR-1Mvan_1228-1e-12184.39% (237) beta-lactamase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


TH_1873|M.thermoresistible__bu      ------------------------VSD---SDRLYFRQLLSGRDFAAGDM
MSMEG_1334|M.smegmatis_MC2_155      --------------------MAERTSDPAANDRFYFRQLLSGRDFAGADP
Mflv_5123|M.gilvum_PYR-GCK          ------------------------MAD---TDRLYFRQLLSGRDFAAGDM
Mvan_1228|M.vanbaalenii_PYR-1       MRPFDRQKDPCARIRRPPLHTLTGMAD---SDRLYFRQLLSGRDYAAGDM
MMAR_0965|M.marinum_M               ------------------------MSDS---DRLYFRQLLAGRDFAVNDM
MUL_0715|M.ulcerans_Agy99           ------------------------MSDS---DRLYFRQLLSGRDFAVNDM
MLBr_01912|M.leprae_Br4923          ------------------------MSDS---DRLYFRQLLSGRDFAVDDV
Mb0651c|M.bovis_AF2122/97           ------------------------MSK----DRLYFRQLLSGRDFAVGDM
Rv0634c|M.tuberculosis_H37Rv        ------------------------MSK----DRLYFRQLLSGRDFAVGDM
MAV_4532|M.avium_104                ------------------------MSD----DRLYFRQLLSGRDFAAGDM
MAB_4755c|M.abscessus_ATCC_199      ------------------------MSG--------IERVITRGTFEL-DG
                                                             :         :.::::   :   * 

TH_1873|M.thermoresistible__bu      MAQQMRNFAYLIGDRETGECVVVDPAYAANDLVDAAEADGMRLTGVLVSH
MSMEG_1334|M.smegmatis_MC2_155      IAQQMRNFAYFIGDRETGEAVVVDPAYAADELAAALEADGMRLAGVLVTH
Mflv_5123|M.gilvum_PYR-GCK          IAQQMRNFAYLIGDRETGDAVVVDPAYAAGELVDALEADGMHLSGVLVTH
Mvan_1228|M.vanbaalenii_PYR-1       IAQQMRNFAYLIGDRETGDTVVVDPAYAAQDLVDALEADGMQLSGVLVTH
MMAR_0965|M.marinum_M               IAAQMRNFAYLIGDRETGDCVVVDPAYAAGDLVNALEADDMHLSGVLVTH
MUL_0715|M.ulcerans_Agy99           IAAQMRNFAYLIGDRETGDCVVVDPAYAAGDLVNALEAGDMHLSGVLVTH
MLBr_01912|M.leprae_Br4923          VATQMRNFAYLIGDRQTGDCVVVDPAYAAGDLVDALEADGMRLSGVLVTH
Mb0651c|M.bovis_AF2122/97           FATQMRNFAYLIGDRTTGDCVVVDPAYAAGDLLDALESDDMQLSGVLVTH
Rv0634c|M.tuberculosis_H37Rv        FATQMRNFAYLIGDRTTGDCVVVDPAYAAGDLLDALESDDMQLSGVLVTH
MAV_4532|M.avium_104                FATQMRNFAYLIGDRQTGDCVVVDPAYAASDLLDTLEADGMHLSGVLVTH
MAB_4755c|M.abscessus_ATCC_199      GSWEVDNNIWIVG--EGDDVVVFDAAHSAQPIIDAVG--GRNVVAVVCTH
                                     : :: *  :::*    .: **.*.*::*  :  :    . .: .*: :*

TH_1873|M.thermoresistible__bu      HHPDHVGGSMMGFTLKGVAELLERAEVPVHVNTHEADWVSRVTGIPLSDL
MSMEG_1334|M.smegmatis_MC2_155      HHPDHVGGSMMGFTLKGVAELLEHRSVPVHVNSHEADWVSQVTGIARSEL
Mflv_5123|M.gilvum_PYR-GCK          HHPDHVGGSMMGFTLKGLAELLERVSVPVHVNAHEADWVSKVTGIAPSEL
Mvan_1228|M.vanbaalenii_PYR-1       HHPDHIGGSMMGFELKGLAELLERVSVPIHVNAHEADWVSRTTGIARSEL
MMAR_0965|M.marinum_M               HHPDHVGGSMMGFELKGLAELLERVSVPVHVNTHEAVWVSRVTGIPMSDL
MUL_0715|M.ulcerans_Agy99           HHPDHVGGSMMGFELKGLAELLERVSVPVHVNTHEAVWVSRVTGIPMSDL
MLBr_01912|M.leprae_Br4923          HHPDHVGGVMMGFQLKGLTELLERVTVPVHVNTHEALWISRVTGIDIGHL
Mb0651c|M.bovis_AF2122/97           HHPDHVGGSMMGFQLPGLAELLERASVPVHVNTHEALWVSRVTGIPVGDL
Rv0634c|M.tuberculosis_H37Rv        HHPDHVGGSMMGFQLPGLAELLERASVPVHVNTHEALWVSRVTGIPVGDL
MAV_4532|M.avium_104                HHPDHVGGSMMGFTLAGLAELVERAPVPVHVNSHEALWVSRVTGISASDL
MAB_4755c|M.abscessus_ATCC_199      GHNDHIT---------VAPELSQALDAPVLL--HPADDVLWRMTHPDKDF
                                     * **:            .** :   .*: :  * *  :         .:

TH_1873|M.thermoresistible__bu      TAHDHGDKVTVGAVEIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
MSMEG_1334|M.smegmatis_MC2_155      SAHEHGDTISVGAIDIELLHTPGHTPGSQCFLVDGR--LVAGDTLFLEGC
Mflv_5123|M.gilvum_PYR-GCK          TTHQHGDTVSIGDIDIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
Mvan_1228|M.vanbaalenii_PYR-1       TAHQHGDKVSVGDIDIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
MMAR_0965|M.marinum_M               TTHEHRDKVSVGDIEIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
MUL_0715|M.ulcerans_Agy99           TTHEHRDKVSVGDIEIELLHTPGHTPGSQCFLLDGQ--LVAGDTLFLEGC
MLBr_01912|M.leprae_Br4923          TTHEHRDKLSVGDIEIELLHTPGHTPGSQCFLLDGL--LVAGDTLFLEGC
Mb0651c|M.bovis_AF2122/97           ITHEHGDKVSVGDIDIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
Rv0634c|M.tuberculosis_H37Rv        ITHEHGDKVSVGDIDIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
MAV_4532|M.avium_104                TAHENHDKVSIGDIEIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
MAB_4755c|M.abscessus_ATCC_199      RAVEDDMVLPVGGLELHALHTPGHSPGSVCWYAPELRAVFSGDTLFQGGP
                                     : :.   :.:* :::. ******:*** *:       :.:*****  * 

TH_1873|M.thermoresistible__bu      GRTDFPGGNVDDMFHSLQ-ALAKLPGDPTVYPGHWYAAEPSASLSEVRRT
MSMEG_1334|M.smegmatis_MC2_155      GRTDFPGGNVDDMFRSLQ-ALAKLPGDPTVYPGHWYSAEPSAPLEEVKRS
Mflv_5123|M.gilvum_PYR-GCK          GRTDFPGGDVDDMFRSLQ-ALAQLPGDPTVFPGHWYSAEPSAPLSDVRGS
Mvan_1228|M.vanbaalenii_PYR-1       GRTDFPGGNVDDMFRSLQ-ALAALPGDPTVFPGHWYSADPSAPLSDVRQT
MMAR_0965|M.marinum_M               GRTDFPGGDSDEIFRSLQ-QLAALPGDPTVFPGHWYSAEPSASLSEVKRS
MUL_0715|M.ulcerans_Agy99           GRTDFPGGDSDEIFRSLQ-QLAALPGDPTVFPGHWYSAEPSASLSEVKRS
MLBr_01912|M.leprae_Br4923          GRTDFPGGNSDEMYRSLQ-QLAQLPGNPTVFPGHWYSTAPSATLSMVKCS
Mb0651c|M.bovis_AF2122/97           GRTDFPGGDSDEMYRSLR-QLAELPGDPTVFPGHWYSAEPSASLSEVKRS
Rv0634c|M.tuberculosis_H37Rv        GRTDFPGGDSDEMYRSLR-QLAELPGDPTVFPGHWYSAEPSASLSEVKRS
MAV_4532|M.avium_104                GRTDFPGGDSDEMYRSLQ-RLAKLPGDPTVFPGHWYSAEPSASLSEVKRS
MAB_4755c|M.abscessus_ATCC_199      GATGRSFSDFPTILRSISGRLGPLPEDTVVYTGHGDTTTIGD--EIVHYD
                                    * *. . .:   : :*:   *. ** :..*:.**  ::  .   . *:  

TH_1873|M.thermoresistible__bu      NYVYRASNLEQWRMLMGA
MSMEG_1334|M.smegmatis_MC2_155      NYVYRASNLDQWRMLMGG
Mflv_5123|M.gilvum_PYR-GCK          NYVYRASNLDQWRMLMGG
Mvan_1228|M.vanbaalenii_PYR-1       NYVYRASDLDQWRMLMGG
MMAR_0965|M.marinum_M               NFVYRAADLAQWRMLMGG
MUL_0715|M.ulcerans_Agy99           NFVYRAADLAQWRMLMGG
MLBr_01912|M.leprae_Br4923          NYVYRAADLNQWRMLMDS
Mb0651c|M.bovis_AF2122/97           NYVYRPASLDQWRMLMGG
Rv0634c|M.tuberculosis_H37Rv        NYVYRPASLDQWRMLMGG
MAV_4532|M.avium_104                NYVYRASDLDQWRMLMGG
MAB_4755c|M.abscessus_ATCC_199      DWVARGH-----------
                                    ::* *