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AERTSDPAANDRFYFRQLLSGRDFAGADPIAQQMRNFAYFIGDRETGEAVVVDPAYAADELAAALEADGM RLAGVLVTHHHPDHVGGSMMGFTLKGVAELLEHRSVPVHVNSHEADWVSQVTGIARSELSAHEHGDTISV GAIDIELLHTPGHTPGSQCFLVDGRLVAGDTLFLEGCGRTDFPGGNVDDMFRSLQALAKLPGDPTVYPGH WYSAEPSAPLEEVKRSNYVYRASNLDQWRMLMGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1334 | - | - | 100% (245) | metallo-beta-lactamase family protein |
| M. smegmatis MC2 155 | MSMEG_2975 | - | 4e-16 | 30.58% (206) | metallo-beta-lactamase family protein |
| M. smegmatis MC2 155 | MSMEG_5385 | - | 1e-13 | 28.82% (229) | metallo-beta-lactamase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0651c | - | 1e-109 | 78.39% (236) | glyoxalase II |
| M. gilvum PYR-GCK | Mflv_5123 | - | 1e-121 | 86.08% (237) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv0634c | - | 1e-109 | 78.39% (236) | glyoxalase II |
| M. leprae Br4923 | MLBr_01912 | - | 1e-104 | 75.97% (233) | putative glyoxylase II |
| M. abscessus ATCC 19977 | MAB_4755c | - | 1e-13 | 30.39% (181) | hypothetical protein MAB_4755c |
| M. marinum M | MMAR_0965 | gloB | 1e-109 | 79.57% (235) | glyoxalase II, GloB |
| M. avium 104 | MAV_4532 | - | 1e-112 | 79.66% (236) | metallo-beta-lactamase family protein |
| M. thermoresistible (build 8) | TH_1873 | - | 1e-118 | 83.76% (234) | POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX |
| M. ulcerans Agy99 | MUL_0715 | gloB | 1e-109 | 79.15% (235) | glyoxalase II, GloB |
| M. vanbaalenii PYR-1 | Mvan_1228 | - | 1e-119 | 83.12% (237) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1334|M.smegmatis_MC2_155 --------------------MAERTSDPAANDRFYFRQLLSGRDFAGADP
TH_1873|M.thermoresistible__bu ------------------------VSD---SDRLYFRQLLSGRDFAAGDM
Mflv_5123|M.gilvum_PYR-GCK ------------------------MAD---TDRLYFRQLLSGRDFAAGDM
Mvan_1228|M.vanbaalenii_PYR-1 MRPFDRQKDPCARIRRPPLHTLTGMAD---SDRLYFRQLLSGRDYAAGDM
MMAR_0965|M.marinum_M ------------------------MSDS---DRLYFRQLLAGRDFAVNDM
MUL_0715|M.ulcerans_Agy99 ------------------------MSDS---DRLYFRQLLSGRDFAVNDM
MLBr_01912|M.leprae_Br4923 ------------------------MSDS---DRLYFRQLLSGRDFAVDDV
Mb0651c|M.bovis_AF2122/97 ------------------------MSK----DRLYFRQLLSGRDFAVGDM
Rv0634c|M.tuberculosis_H37Rv ------------------------MSK----DRLYFRQLLSGRDFAVGDM
MAV_4532|M.avium_104 ------------------------MSD----DRLYFRQLLSGRDFAAGDM
MAB_4755c|M.abscessus_ATCC_199 ------------------------MSG--------IERVITRGTFEL-DG
: :.:::: : *
MSMEG_1334|M.smegmatis_MC2_155 IAQQMRNFAYFIGDRETGEAVVVDPAYAADELAAALEADGMRLAGVLVTH
TH_1873|M.thermoresistible__bu MAQQMRNFAYLIGDRETGECVVVDPAYAANDLVDAAEADGMRLTGVLVSH
Mflv_5123|M.gilvum_PYR-GCK IAQQMRNFAYLIGDRETGDAVVVDPAYAAGELVDALEADGMHLSGVLVTH
Mvan_1228|M.vanbaalenii_PYR-1 IAQQMRNFAYLIGDRETGDTVVVDPAYAAQDLVDALEADGMQLSGVLVTH
MMAR_0965|M.marinum_M IAAQMRNFAYLIGDRETGDCVVVDPAYAAGDLVNALEADDMHLSGVLVTH
MUL_0715|M.ulcerans_Agy99 IAAQMRNFAYLIGDRETGDCVVVDPAYAAGDLVNALEAGDMHLSGVLVTH
MLBr_01912|M.leprae_Br4923 VATQMRNFAYLIGDRQTGDCVVVDPAYAAGDLVDALEADGMRLSGVLVTH
Mb0651c|M.bovis_AF2122/97 FATQMRNFAYLIGDRTTGDCVVVDPAYAAGDLLDALESDDMQLSGVLVTH
Rv0634c|M.tuberculosis_H37Rv FATQMRNFAYLIGDRTTGDCVVVDPAYAAGDLLDALESDDMQLSGVLVTH
MAV_4532|M.avium_104 FATQMRNFAYLIGDRQTGDCVVVDPAYAASDLLDTLEADGMHLSGVLVTH
MAB_4755c|M.abscessus_ATCC_199 GSWEVDNNIWIVG--EGDDVVVFDAAHSAQPIIDAVG--GRNVVAVVCTH
: :: * :::* .: **.*.*::* : : . .: .*: :*
MSMEG_1334|M.smegmatis_MC2_155 HHPDHVGGSMMGFTLKGVAELLEHRSVPVHVNSHEADWVSQVTGIARSEL
TH_1873|M.thermoresistible__bu HHPDHVGGSMMGFTLKGVAELLERAEVPVHVNTHEADWVSRVTGIPLSDL
Mflv_5123|M.gilvum_PYR-GCK HHPDHVGGSMMGFTLKGLAELLERVSVPVHVNAHEADWVSKVTGIAPSEL
Mvan_1228|M.vanbaalenii_PYR-1 HHPDHIGGSMMGFELKGLAELLERVSVPIHVNAHEADWVSRTTGIARSEL
MMAR_0965|M.marinum_M HHPDHVGGSMMGFELKGLAELLERVSVPVHVNTHEAVWVSRVTGIPMSDL
MUL_0715|M.ulcerans_Agy99 HHPDHVGGSMMGFELKGLAELLERVSVPVHVNTHEAVWVSRVTGIPMSDL
MLBr_01912|M.leprae_Br4923 HHPDHVGGVMMGFQLKGLTELLERVTVPVHVNTHEALWISRVTGIDIGHL
Mb0651c|M.bovis_AF2122/97 HHPDHVGGSMMGFQLPGLAELLERASVPVHVNTHEALWVSRVTGIPVGDL
Rv0634c|M.tuberculosis_H37Rv HHPDHVGGSMMGFQLPGLAELLERASVPVHVNTHEALWVSRVTGIPVGDL
MAV_4532|M.avium_104 HHPDHVGGSMMGFTLAGLAELVERAPVPVHVNSHEALWVSRVTGISASDL
MAB_4755c|M.abscessus_ATCC_199 GHNDHIT---------VAPELSQALDAPVLL--HPADDVLWRMTHPDKDF
* **: .** : .*: : * * : .:
MSMEG_1334|M.smegmatis_MC2_155 SAHEHGDTISVGAIDIELLHTPGHTPGSQCFLVDGR--LVAGDTLFLEGC
TH_1873|M.thermoresistible__bu TAHDHGDKVTVGAVEIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
Mflv_5123|M.gilvum_PYR-GCK TTHQHGDTVSIGDIDIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
Mvan_1228|M.vanbaalenii_PYR-1 TAHQHGDKVSVGDIDIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
MMAR_0965|M.marinum_M TTHEHRDKVSVGDIEIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
MUL_0715|M.ulcerans_Agy99 TTHEHRDKVSVGDIEIELLHTPGHTPGSQCFLLDGQ--LVAGDTLFLEGC
MLBr_01912|M.leprae_Br4923 TTHEHRDKLSVGDIEIELLHTPGHTPGSQCFLLDGL--LVAGDTLFLEGC
Mb0651c|M.bovis_AF2122/97 ITHEHGDKVSVGDIDIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
Rv0634c|M.tuberculosis_H37Rv ITHEHGDKVSVGDIDIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
MAV_4532|M.avium_104 TAHENHDKVSIGDIEIELLHTPGHTPGSQCFLLDGR--LVAGDTLFLEGC
MAB_4755c|M.abscessus_ATCC_199 RAVEDDMVLPVGGLELHALHTPGHSPGSVCWYAPELRAVFSGDTLFQGGP
: :. :.:* :::. ******:*** *: :.:***** *
MSMEG_1334|M.smegmatis_MC2_155 GRTDFPGGNVDDMFRSLQ-ALAKLPGDPTVYPGHWYSAEPSAPLEEVKRS
TH_1873|M.thermoresistible__bu GRTDFPGGNVDDMFHSLQ-ALAKLPGDPTVYPGHWYAAEPSASLSEVRRT
Mflv_5123|M.gilvum_PYR-GCK GRTDFPGGDVDDMFRSLQ-ALAQLPGDPTVFPGHWYSAEPSAPLSDVRGS
Mvan_1228|M.vanbaalenii_PYR-1 GRTDFPGGNVDDMFRSLQ-ALAALPGDPTVFPGHWYSADPSAPLSDVRQT
MMAR_0965|M.marinum_M GRTDFPGGDSDEIFRSLQ-QLAALPGDPTVFPGHWYSAEPSASLSEVKRS
MUL_0715|M.ulcerans_Agy99 GRTDFPGGDSDEIFRSLQ-QLAALPGDPTVFPGHWYSAEPSASLSEVKRS
MLBr_01912|M.leprae_Br4923 GRTDFPGGNSDEMYRSLQ-QLAQLPGNPTVFPGHWYSTAPSATLSMVKCS
Mb0651c|M.bovis_AF2122/97 GRTDFPGGDSDEMYRSLR-QLAELPGDPTVFPGHWYSAEPSASLSEVKRS
Rv0634c|M.tuberculosis_H37Rv GRTDFPGGDSDEMYRSLR-QLAELPGDPTVFPGHWYSAEPSASLSEVKRS
MAV_4532|M.avium_104 GRTDFPGGDSDEMYRSLQ-RLAKLPGDPTVFPGHWYSAEPSASLSEVKRS
MAB_4755c|M.abscessus_ATCC_199 GATGRSFSDFPTILRSISGRLGPLPEDTVVYTGHGDTTTIGD--EIVHYD
* *. . .: : :*: *. ** :..*:.** :: . . *:
MSMEG_1334|M.smegmatis_MC2_155 NYVYRASNLDQWRMLMGG
TH_1873|M.thermoresistible__bu NYVYRASNLEQWRMLMGA
Mflv_5123|M.gilvum_PYR-GCK NYVYRASNLDQWRMLMGG
Mvan_1228|M.vanbaalenii_PYR-1 NYVYRASDLDQWRMLMGG
MMAR_0965|M.marinum_M NFVYRAADLAQWRMLMGG
MUL_0715|M.ulcerans_Agy99 NFVYRAADLAQWRMLMGG
MLBr_01912|M.leprae_Br4923 NYVYRAADLNQWRMLMDS
Mb0651c|M.bovis_AF2122/97 NYVYRPASLDQWRMLMGG
Rv0634c|M.tuberculosis_H37Rv NYVYRPASLDQWRMLMGG
MAV_4532|M.avium_104 NYVYRASDLDQWRMLMGG
MAB_4755c|M.abscessus_ATCC_199 DWVARGH-----------
::* *