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M. thermoresistible (build 8) TH_1415 (purT)

annotation: PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT (GART 2) (GAR TRANSFORMYLASE 2) (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE 2) (FORMATE-DEPENDENT GAR TRANSFORMYLASE)
coordinates: 2668428 - 2669762
length: 445

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1415purT-100% (445)PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT (GART 2) (GAR TRANSFORMYLASE 2) (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE 2) (FORMATE-DEPENDENT GAR TRANSFORMYLASE)
M. thermoresistible (build 8)TH_0889purK5e-1627.83% (327) PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE
M. thermoresistible (build 8)TH_3286-3e-1225.06% (403) PUTATIVE acetyl-/propionyl-coenzyme A carboxylase alpha chain

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0395purT1e-11256.25% (416) phosphoribosylglycinamide formyltransferase 2
M. gilvum PYR-GCKMflv_0222-1e-12461.43% (407) ATP-dependent carboxylate-amine ligase domain-containing
M. tuberculosis H37RvRv0389purT1e-11356.49% (416) phosphoribosylglycinamide formyltransferase 2
M. leprae Br4923MLBr_00735purK7e-1726.65% (334) phosphoribosylaminoimidazole carboxylase ATPase subunit
M. abscessus ATCC 19977MAB_4245c-1e-11551.25% (439) phosphoribosylglycinamide formyltransferase 2
M. marinum MMMAR_0686purT1e-10752.24% (446) formate-dependent phosphoribosylglycinamide
M. avium 104MAV_4775purT1e-11253.86% (440) phosphoribosylglycinamide formyltransferase 2
M. smegmatis MC2 155MSMEG_0766purT1e-15967.49% (446) phosphoribosylglycinamide formyltransferase 2
M. ulcerans Agy99MUL_2628purK1e-1627.15% (361) phosphoribosylaminoimidazole carboxylase ATPase subunit
M. vanbaalenii PYR-1Mvan_0685-1e-13164.32% (398) ATP-dependent carboxylate-amine ligase domain-containing

CLUSTAL 2.0.9 multiple sequence alignment


Mb0395|M.bovis_AF2122/97            --------------------------------------------------
Rv0389|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0686|M.marinum_M               --------------------------------------------------
MAV_4775|M.avium_104                --------------------------------------------------
TH_1415|M.thermoresistible__bu      --------------------------------------------------
MSMEG_0766|M.smegmatis_MC2_155      ------------------------------------MSESIEGALTDDAA
Mflv_0222|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0685|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4245c|M.abscessus_ATCC_199      MNGIVVTQEGSPPSEQGTATSADIVEPVPAAAAPVTEEAVRATNGAKSGS
MLBr_00735|M.leprae_Br4923          --------------------------------------------------
MUL_2628|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

Mb0395|M.bovis_AF2122/97            ----------------------------MIDGWTEGQHEPTVRHERPAAP
Rv0389|M.tuberculosis_H37Rv         ----------------------------MIDGWTEEQHEPTVRHERPAAP
MMAR_0686|M.marinum_M               ----------------------------MTDGLTEGHDEAIGKHQRPATE
MAV_4775|M.avium_104                ----------------------------MTDGRDDETTALAVPRPAPAEG
TH_1415|M.thermoresistible__bu      -------------VTDPATDPTAEQATDPVAEAAGPGGEPKLQAGAPVDD
MSMEG_0766|M.smegmatis_MC2_155      ADESAGAGPDDTDVTDDSVADTAPEDTAPDPDDTEPGDRAAADQETDTDP
Mflv_0222|M.gilvum_PYR-GCK          --------------------------------------------MTEMET
Mvan_0685|M.vanbaalenii_PYR-1       --------------------------------------------MSDTN-
MAB_4245c|M.abscessus_ATCC_199      KTAKAATPVEAVGKTVEAGAPAPEAVADLAEGHTEDRTGQAVPQPPEAPA
MLBr_00735|M.leprae_Br4923          ------------------------------------------MMAVPSRC
MUL_2628|M.ulcerans_Agy99           ----------------------MIHNDLVLQPPNTPVMGHDTMMAVPS--
                                                                                      

Mb0395|M.bovis_AF2122/97            ---------------------------QDVR-RVMLLGSAEPSRELAIAL
Rv0389|M.tuberculosis_H37Rv         ---------------------------QDVR-RVMLLGSAEPSRELAIAL
MMAR_0686|M.marinum_M               GANAPEGDKTTTIAVPPVGTPRRAEADVHVRPRVVLLGGGEQGRELTIAL
MAV_4775|M.avium_104                GPAPADG----------------GPAPADGRPAVMLLGSGDISRELAIAL
TH_1415|M.thermoresistible__bu      EPAAQAEP------------------ARPARPTVMLLGAGELSRELVLAF
MSMEG_0766|M.smegmatis_MC2_155      EPQPVVGPD-----------------AADHRPTVMLLGGGALSRELALAF
Mflv_0222|M.gilvum_PYR-GCK          --------------------------AHEGRTVVLLLGAGERTRELAPAF
Mvan_0685|M.vanbaalenii_PYR-1       ------------------------------GETVLLLGAGERSSELALAF
MAB_4245c|M.abscessus_ATCC_199      PADLPADEAEP---------------PAGNRTTVMLLGSGELAKELAISF
MLBr_00735|M.leprae_Br4923          --------------------------SLGVAPLVAMVGGGQLARMTHQAA
MUL_2628|M.ulcerans_Agy99           ----------------------------SRTPQVAMVGGGQLARMTHQAA
                                                                     * ::*..        : 

Mb0395|M.bovis_AF2122/97            QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVT
Rv0389|M.tuberculosis_H37Rv         QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVT
MMAR_0686|M.marinum_M               QGLGAEVIAVDTDADAPAHRVADQALVVAMTDADELKVVFTRLRPDFVVP
MAV_4775|M.avium_104                GRLGARVIAVDAHPQAPAHAVADQALVLPLTDAGELSAAIHRLRPDVVVS
TH_1415|M.thermoresistible__bu      QRLGAEVVAVDRYADAPAYPVADRSVVATMSDADALTAVIEREAPQYVVA
MSMEG_0766|M.smegmatis_MC2_155      QNLGGVVVAVDRY-DAPAHGVADRTAVVDLNDADELSAVIAREKPQYVVA
Mflv_0222|M.gilvum_PYR-GCK          EHLGAQVVTADAA-----------------ADAQTLTALIEQHAARYVVA
Mvan_0685|M.vanbaalenii_PYR-1       RHLGADVVTVSDH-----------------GETQALTALIDERRPRYVVA
MAB_4245c|M.abscessus_ATCC_199      QRLGAEVIVVDTGKGGPAQGVADRAVLAPIGESERLYELIEKERPRFVVP
MLBr_00735|M.leprae_Br4923          IALGQTLRVLATAADEPAAQVTPDVVIGSHTDLEDLRRVALGADALTFDH
MUL_2628|M.ulcerans_Agy99           IALGQNLRVLVNSADDPAAQVTPNVVIGSHTDLDDLRRIAAGADVVTFDH
                                      **  : .                      :   *           .  

Mb0395|M.bovis_AF2122/97            VTA------AVSVDALDAVEQ---ADGECTELVPNARAVRCTADREGLR-
Rv0389|M.tuberculosis_H37Rv         VTA------AVSVDALDAVEQ---ADGECTELVPNARAVRCTADREGLR-
MMAR_0686|M.marinum_M               LTD------AVSVAALDALADRAPSEGGSIGLVPSARCVRLAGDREALR-
MAV_4775|M.avium_104                TTD------AVAVPALEALDG------TGAEPVPSARAVRLAADREGLR-
TH_1415|M.thermoresistible__bu      EST------AVAVDALIAVAE-----RGSVEVFPTPRAIRLSYDREGLR-
MSMEG_0766|M.smegmatis_MC2_155      AESG-----VIAADALIAAAE-----RGDSEVLPTPRSIRLSQNREGLR-
Mflv_0222|M.gilvum_PYR-GCK          DLDTAEATNVATTGALHAIAD-----RDDVEVFPTLRSIRFALDGEALR-
Mvan_0685|M.vanbaalenii_PYR-1       D-----AATVATD-ALIAVAE-----RDDVEVFPTPRATRLSLDGEGLR-
MAB_4245c|M.abscessus_ATCC_199      LVE------AASREALDKLAEG-----EVTQVIPTAKAVRLAGDREGMR-
MLBr_00735|M.leprae_Br4923          EH--------VPTELLDKLVA------EGINVAPSPQALVHAQDKLVMRR
MUL_2628|M.ulcerans_Agy99           EH--------VPAELLDKLVA------EGVVLAPPPQALVHAQDKLVMRR
                                               .   *                 *  :.   : :   :* 

Mb0395|M.bovis_AF2122/97            RLAADQLGLP-TAPFWFVGSLGELQAVAVHAG----FPLLVSPVAGVAGQ
Rv0389|M.tuberculosis_H37Rv         RLAADQLGLP-TAPFWFVGSLGELQAVAVHAG----FPLLVSPVAGVAGQ
MMAR_0686|M.marinum_M               KLAADQLGLP-TAPFWFVGSLGELEAVAAHVG----YPLLVKPVAGADVP
MAV_4775|M.avium_104                RLAADELGLP-TAPFWFAGSLGELEAVGAHAG----YPLLVKPVVGAVGP
TH_1415|M.thermoresistible__bu      RLAADELGLP-TAPFWFAGSVEELTAVAQHAG----FPLVVRPVTGPAGS
MSMEG_0766|M.smegmatis_MC2_155      RLASDELGLP-TVPFWFAGSVEELTAVAEHAG----YPLVVKPVTGSLRD
Mflv_0222|M.gilvum_PYR-GCK          RLAADELGLP-TAPFWFAGTVEELTAIGQHAG----FPLVVKPVSGAPGE
Mvan_0685|M.vanbaalenii_PYR-1       RLAADELGLP-TAPFWFAGSVEELTAIVAHAG----FPMVVKPVAAAPGE
MAB_4245c|M.abscessus_ATCC_199      RMAAEELGLP-TPTYWFANSVEELRTVLETSG----FPAVVRPVAAAYGQ
MLBr_00735|M.leprae_Br4923          RLAALGAAMPRFMALDSVDDLAEIDAFAQRLTGSKDAPMVVKAVRGGYDG
MUL_2628|M.ulcerans_Agy99           RLQALDVPVPRYLGIHQLEELGELDAFARQL----DAPLVVKAVRGGYDG
                                    :: :    :*          : *: :.          * :* .* .    

Mb0395|M.bovis_AF2122/97            GSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIEFLVTMIV
Rv0389|M.tuberculosis_H37Rv         GSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIEFLVTMIV
MMAR_0686|M.marinum_M               RRSLVRGPDEVEAAWARAVAG----GPAGAPPRVWAETQVEVEFLVTLIA
MAV_4775|M.avium_104                RQSVVAGREDIAAAWHRAVDG----QPG---ARVLAETVVEVQFHVMLLA
TH_1415|M.thermoresistible__bu      GQSVLLREDDVEPAWHRAIAAGHF-----AQNRVMAETVVEIDYEVTMLT
MSMEG_0766|M.smegmatis_MC2_155      GQSVLLRPDDIEPAWKRATTAGHF-----AHSRVLAESVVEVDFEVTMLT
Mflv_0222|M.gilvum_PYR-GCK          GESVLLRPEDVEPAWQRAVAAGAP-----TRRRVIAESVVEVDVEVTLLT
Mvan_0685|M.vanbaalenii_PYR-1       GESVLLRPDDVEPAWRHATAAGN-------LKRVIAETVVEVDFEVTLLT
MAB_4245c|M.abscessus_ATCC_199      GQSVVLRDGDVTPAWEQAIAANIG-----GGQRVMVETAVDIDYEITLLT
MLBr_00735|M.leprae_Br4923          RGVQMVR--DSAHAREVASGYLVD------GMPVLVEERVELRRELSALV
MUL_2628|M.ulcerans_Agy99           RGVQMAR--DLADARDIASGYLAG------GVPVLVEERVQLRRELSALV
                                        :    :   *   *               * .*  *::   :  :.

Mb0395|M.bovis_AF2122/97            VCSQGPNGPL-IEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAAR
Rv0389|M.tuberculosis_H37Rv         VCSQGPNGPL-IEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAAR
MMAR_0686|M.marinum_M               VCSQGPQGPR-IDFCAPIGH-GGDGGDQESWQPQKVSVAALDAAKSIAAR
MAV_4775|M.avium_104                VRSEGAAGPA-IEFCSPIGHRGAGGRVLESWQPQKMSPAAMDAAKSIAAR
TH_1415|M.thermoresistible__bu      VRTTGPAGPT-IRFCEPIGHHHRNGEVLELWQPQQMSPVALDAAKSIAAR
MSMEG_0766|M.smegmatis_MC2_155      IRTTGPTGPG-VQFCEPIGHRRSDNGVLESWQPQQMPPAALDSAKSIAAR
Mflv_0222|M.gilvum_PYR-GCK          VRTAGPAGPT-VSFCEPIGHHQSPEGSLESWQPQQLSPVALDSAKSIAAR
Mvan_0685|M.vanbaalenii_PYR-1       VRTTGAAGPT-VHFCEPIGHHQNDDDALESWQPQQLSPTALDSAKSIAAR
MAB_4245c|M.abscessus_ATCC_199      VRTAGIGGATRLYFCEPIAHRQSGTDAMQMWQPQPLSQAALELARSIAAR
MLBr_00735|M.leprae_Br4923          ARSPFGQGAA---WPVVETVQRDGICVLVVAPALALADDLASAAQQLALR
MUL_2628|M.ulcerans_Agy99           ARSPFGQGAA---WPVVETVQQDGICVAVIAPAPALSAQAGADAQQLALR
                                      :    *.    :                  .  :.      *:.:* *

Mb0395|M.bovis_AF2122/97            IVKALGGRGVFGVELMINGD-EVYFADVTVCPAGSAWVTVRSQRLSVFEL
Rv0389|M.tuberculosis_H37Rv         IVKALGGRGVFGVELMINGD-EVYFADVTVCPAGSAWVTVRSQRLSVFEL
MMAR_0686|M.marinum_M               IVKALGGCGVFGVELMVNGD-EVYFADVQPFPRDTAWVTLRSQRLSVFEL
MAV_4775|M.avium_104                IVKALGGRGVFGVELMVNDD-EVYFADVTAHPGDSAWVTVRSQRLSAFEL
TH_1415|M.thermoresistible__bu      IVNSLGGRGVYGVELLVRDD-EVYFSDVRVRPQDTGLVTLRSQRLSHFEL
MSMEG_0766|M.smegmatis_MC2_155      IVNSLGGRGVFGVELLVQGE-DVYFSDVRVRPHDSGLVTLRSQRLSEFEL
Mflv_0222|M.gilvum_PYR-GCK          IVNSLGGRGVFAVELLVRGD-EVYFSDVRPRLQDSGLVTLRSQRLSQFEL
Mvan_0685|M.vanbaalenii_PYR-1       IVNSLGGRGVFAVELLVRGD-EVYFSDVRPRLQDSGLVTLRSQRLSQFEL
MAB_4245c|M.abscessus_ATCC_199      AVNALGGHGVYGVELFVRGD-EVYFCDVSARPYDSGLVTVRSQRLSEYDM
MLBr_00735|M.leprae_Br4923          LAAELGVVGVFAVELFETADGALLVNELAMRPHNSGHWTMDGARTSQFEQ
MUL_2628|M.ulcerans_Agy99           LAAELGVVGVLAVELFETTDGALVVNELAMRPHNSGHWTMDGSRTSQFEQ
                                     .  **  ** .***:   :  : . ::     .:.  *: . * * :: 

Mb0395|M.bovis_AF2122/97            QARATLGLAVDTLMISPGAARVINPDHTAGRAAV-GAAPPADALTGALGV
Rv0389|M.tuberculosis_H37Rv         QARAILGLAVDTLMISPGAARVINPDHTAGRAAV-GAAPPADALTGALGV
MMAR_0686|M.marinum_M               QARAILGFAVDTLMVSPGAARLI------GAATV-GPVPGADALAAALAV
MAV_4775|M.avium_104                QARTILGLPVDTMMVSPAAARVVD------SADP-GDR---AALSGALGV
TH_1415|M.thermoresistible__bu      HARAILGLAVDTIMISPAAAEVHYGGSEAAWPGGTGGAELTAVLREALSV
MSMEG_0766|M.smegmatis_MC2_155      HARAILGLACDTIMISPGAAEVTYAGAEAAPS-----VDVTAVLGEALAT
Mflv_0222|M.gilvum_PYR-GCK          HARAVLGLPVDTIMISPGAAEVTCS----------ADADARLVLGEALAV
Mvan_0685|M.vanbaalenii_PYR-1       HARAVLGLPVDTIMISPGAVEVSYPDGEGRAV---PDREIRAVLADALAV
MAB_4245c|M.abscessus_ATCC_199      HARAVLGAPVDTILVSPAAAEVVYGD---------GDGPSPRQLDQALQT
MLBr_00735|M.leprae_Br4923          HLRAVLDYPLGETDAVAPVTVMVNVLGAPQPPTLSVVTMDERLHHLFARM
MUL_2628|M.ulcerans_Agy99           HLRAVLDYPLGDTEAIAPVTVMTNVLGAAAQPAMS---LDERLHHLFARM
                                    : *: *. . .     . .. :                            

Mb0395|M.bovis_AF2122/97            PESDVVIFGRG----------LGVALAT-APEVAIARERAREVASRLNVP
Rv0389|M.tuberculosis_H37Rv         PESDVVIFGRG----------LGVALAT-APEVAIARERAREVASRLNVP
MMAR_0686|M.marinum_M               PESDVRVFGRPRA----GSSVLGVALAT-APDVAVARDRAREVVDRLNVR
MAV_4775|M.avium_104                PESDLRVCGRG-----------FRALAT-APEVAAARERAGQVAARLTAG
TH_1415|M.thermoresistible__bu      PESDVRLFG-GPDDETDAPHRLGVALAT-APDATAARRQVRQVSTALRRL
MSMEG_0766|M.smegmatis_MC2_155      SESDVRLFG-RAE-ESDDGRRLGVALAT-APDVIVARDRARRVGTALRRL
Mflv_0222|M.gilvum_PYR-GCK          AESDVRVLRSEPP--------VRVSLAT-APDPIVARDRARRVASALRRS
Mvan_0685|M.vanbaalenii_PYR-1       AESDVRLFPATAAGDDDDVPWLSWSTAT-AQDPIVARDRARRVATAVRRL
MAB_4245c|M.abscessus_ATCC_199      PESDLRVFGHTEAHR---RRRVAVALAT-APNTALALNRAQQVARHLR--
MLBr_00735|M.leprae_Br4923          PDARVHLYDKVERPGRKVGHINFRGTDKDRKNPTKLRERAELAAHWLSHG
MUL_2628|M.ulcerans_Agy99           PDARVHLYGKDERPGRKVGHINFLGFDP--AAVAGLRERAELAAHWLSHG
                                    .:: : :                 .             :.  .   :   

Mb0395|M.bovis_AF2122/97            DSRE----------------------------
Rv0389|M.tuberculosis_H37Rv         DSRE----------------------------
MMAR_0686|M.marinum_M               DSRG----------------------------
MAV_4775|M.avium_104                AGGVGGAGG-----------------------
TH_1415|M.thermoresistible__bu      W-------------------------------
MSMEG_0766|M.smegmatis_MC2_155      W-------------------------------
Mflv_0222|M.gilvum_PYR-GCK          V-------------------------------
Mvan_0685|M.vanbaalenii_PYR-1       R-------------------------------
MAB_4245c|M.abscessus_ATCC_199      --------------------------------
MLBr_00735|M.leprae_Br4923          QWTDGWDPHRAGDDVVEISLACGGRNDAQRQR
MUL_2628|M.ulcerans_Agy99           QWTDGWDPHG----------------------