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TEMETAHEGRTVVLLLGAGERTRELAPAFEHLGAQVVTADAAADAQTLTALIEQHAARYVVADLDTAEAT NVATTGALHAIADRDDVEVFPTLRSIRFALDGEALRRLAADELGLPTAPFWFAGTVEELTAIGQHAGFPL VVKPVSGAPGEGESVLLRPEDVEPAWQRAVAAGAPTRRRVIAESVVEVDVEVTLLTVRTAGPAGPTVSFC EPIGHHQSPEGSLESWQPQQLSPVALDSAKSIAARIVNSLGGRGVFAVELLVRGDEVYFSDVRPRLQDSG LVTLRSQRLSQFELHARAVLGLPVDTIMISPGAAEVTCSADADARLVLGEALAVAESDVRVLRSEPPVRV SLATAPDPIVARDRARRVASALRRSV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0222 | - | - | 100% (377) | ATP-dependent carboxylate-amine ligase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2039 | purT | 6e-72 | 41.60% (387) | phosphoribosylglycinamide formyltransferase 2 |
| M. gilvum PYR-GCK | Mflv_4747 | - | 7e-15 | 29.30% (314) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0395 | purT | 1e-89 | 48.85% (393) | phosphoribosylglycinamide formyltransferase 2 |
| M. tuberculosis H37Rv | Rv0389 | purT | 5e-90 | 48.85% (393) | phosphoribosylglycinamide formyltransferase 2 |
| M. leprae Br4923 | MLBr_00735 | purK | 2e-10 | 28.71% (310) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
| M. abscessus ATCC 19977 | MAB_4245c | - | 2e-92 | 47.73% (396) | phosphoribosylglycinamide formyltransferase 2 |
| M. marinum M | MMAR_0686 | purT | 3e-88 | 50.77% (392) | formate-dependent phosphoribosylglycinamide |
| M. avium 104 | MAV_4775 | purT | 3e-92 | 52.39% (376) | phosphoribosylglycinamide formyltransferase 2 |
| M. smegmatis MC2 155 | MSMEG_0766 | purT | 1e-121 | 61.11% (396) | phosphoribosylglycinamide formyltransferase 2 |
| M. thermoresistible (build 8) | TH_1415 | purT | 1e-124 | 61.43% (407) | PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT |
| M. ulcerans Agy99 | MUL_2628 | purK | 1e-10 | 28.88% (322) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
| M. vanbaalenii PYR-1 | Mvan_0685 | - | 1e-142 | 72.68% (377) | ATP-dependent carboxylate-amine ligase domain-containing |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0395|M.bovis_AF2122/97 --------------------------------------------------
Rv0389|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0686|M.marinum_M --------------------------------------------------
MAV_4775|M.avium_104 --------------------------------------------------
Mflv_0222|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0685|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0766|M.smegmatis_MC2_155 ------------------------------------MSESIEGALTDDAA
TH_1415|M.thermoresistible__bu --------------------------------------------------
MAB_4245c|M.abscessus_ATCC_199 MNGIVVTQEGSPPSEQGTATSADIVEPVPAAAAPVTEEAVRATNGAKSGS
MLBr_00735|M.leprae_Br4923 --------------------------------------------------
MUL_2628|M.ulcerans_Agy99 --------------------------------------------------
Mb0395|M.bovis_AF2122/97 ----------------------------MIDGWTEGQHEPTVRHERPAAP
Rv0389|M.tuberculosis_H37Rv ----------------------------MIDGWTEEQHEPTVRHERPAAP
MMAR_0686|M.marinum_M ----------------------------MTDGLTEGHDEAIGKHQRPATE
MAV_4775|M.avium_104 ----------------------------MTDGRDDETTALAVPRPAPAEG
Mflv_0222|M.gilvum_PYR-GCK --------------------------------------------MTEMET
Mvan_0685|M.vanbaalenii_PYR-1 --------------------------------------------MSDTN-
MSMEG_0766|M.smegmatis_MC2_155 ADESAGAGPDDTDVTDDSVADTAPEDTAPDPDDTEPGDRAAADQETDTDP
TH_1415|M.thermoresistible__bu -------------VTDPATDPTAEQATDPVAEAAGPGGEPKLQAGAPVDD
MAB_4245c|M.abscessus_ATCC_199 KTAKAATPVEAVGKTVEAGAPAPEAVADLAEGHTEDRTGQAVPQPPEAPA
MLBr_00735|M.leprae_Br4923 ------------------------------------------MMAVPSRC
MUL_2628|M.ulcerans_Agy99 ----------------------MIHNDLVLQPPNTPVMGHDTMMAVPS--
Mb0395|M.bovis_AF2122/97 ---------------------------QDVR-RVMLLGSAEPSRELAIAL
Rv0389|M.tuberculosis_H37Rv ---------------------------QDVR-RVMLLGSAEPSRELAIAL
MMAR_0686|M.marinum_M GANAPEGDKTTTIAVPPVGTPRRAEADVHVRPRVVLLGGGEQGRELTIAL
MAV_4775|M.avium_104 GPAPADG----------------GPAPADGRPAVMLLGSGDISRELAIAL
Mflv_0222|M.gilvum_PYR-GCK --------------------------AHEGRTVVLLLGAGERTRELAPAF
Mvan_0685|M.vanbaalenii_PYR-1 ------------------------------GETVLLLGAGERSSELALAF
MSMEG_0766|M.smegmatis_MC2_155 EPQPVVGPD-----------------AADHRPTVMLLGGGALSRELALAF
TH_1415|M.thermoresistible__bu EPAAQAEP------------------ARPARPTVMLLGAGELSRELVLAF
MAB_4245c|M.abscessus_ATCC_199 PADLPADEAEP---------------PAGNRTTVMLLGSGELAKELAISF
MLBr_00735|M.leprae_Br4923 --------------------------SLGVAPLVAMVGGGQLARMTHQAA
MUL_2628|M.ulcerans_Agy99 ----------------------------SRTPQVAMVGGGQLARMTHQAA
* ::*.. :
Mb0395|M.bovis_AF2122/97 QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVT
Rv0389|M.tuberculosis_H37Rv QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVT
MMAR_0686|M.marinum_M QGLGAEVIAVDTDADAPAHRVADQALVVAMTDADELKVVFTRLRPDFVVP
MAV_4775|M.avium_104 GRLGARVIAVDAHPQAPAHAVADQALVLPLTDAGELSAAIHRLRPDVVVS
Mflv_0222|M.gilvum_PYR-GCK EHLGAQVVTADAA-----------------ADAQTLTALIEQHAARYVVA
Mvan_0685|M.vanbaalenii_PYR-1 RHLGADVVTVSDH-----------------GETQALTALIDERRPRYVVA
MSMEG_0766|M.smegmatis_MC2_155 QNLGGVVVAVDRY-DAPAHGVADRTAVVDLNDADELSAVIAREKPQYVVA
TH_1415|M.thermoresistible__bu QRLGAEVVAVDRYADAPAYPVADRSVVATMSDADALTAVIEREAPQYVVA
MAB_4245c|M.abscessus_ATCC_199 QRLGAEVIVVDTGKGGPAQGVADRAVLAPIGESERLYELIEKERPRFVVP
MLBr_00735|M.leprae_Br4923 IALGQTLRVLATAADEPAAQVTPDVVIGSHTDLEDLRRVALGADALTFDH
MUL_2628|M.ulcerans_Agy99 IALGQNLRVLVNSADDPAAQVTPNVVIGSHTDLDDLRRIAAGADVVTFDH
** : . : * .
Mb0395|M.bovis_AF2122/97 VTA-----AVSVD-ALDAVEQ---ADGECTELVPNARAVRCTADREGLR-
Rv0389|M.tuberculosis_H37Rv VTA-----AVSVD-ALDAVEQ---ADGECTELVPNARAVRCTADREGLR-
MMAR_0686|M.marinum_M LTD-----AVSVA-ALDALADRAPSEGGSIGLVPSARCVRLAGDREALR-
MAV_4775|M.avium_104 TTD-----AVAVP-ALEALDG------TGAEPVPSARAVRLAADREGLR-
Mflv_0222|M.gilvum_PYR-GCK DLDTAEATNVATTGALHAIAD-----RDDVEVFPTLRSIRFALDGEALR-
Mvan_0685|M.vanbaalenii_PYR-1 D-----AATVATD-ALIAVAE-----RDDVEVFPTPRATRLSLDGEGLR-
MSMEG_0766|M.smegmatis_MC2_155 AESG----VIAAD-ALIAAAE-----RGDSEVLPTPRSIRLSQNREGLR-
TH_1415|M.thermoresistible__bu EST-----AVAVD-ALIAVAE-----RGSVEVFPTPRAIRLSYDREGLR-
MAB_4245c|M.abscessus_ATCC_199 LVE------AASREALDKLAEG-----EVTQVIPTAKAVRLAGDREGMR-
MLBr_00735|M.leprae_Br4923 EH-------VPTELLDKLVAEG-------INVAPSPQALVHAQDKLVMRR
MUL_2628|M.ulcerans_Agy99 EH-------VPAELLDKLVAEG-------VVLAPPPQALVHAQDKLVMRR
. * :. : : :*
Mb0395|M.bovis_AF2122/97 RLAADQLGLP-TAPFWFVGSLGELQAVAVHAG----FPLLVSPVAGVAGQ
Rv0389|M.tuberculosis_H37Rv RLAADQLGLP-TAPFWFVGSLGELQAVAVHAG----FPLLVSPVAGVAGQ
MMAR_0686|M.marinum_M KLAADQLGLP-TAPFWFVGSLGELEAVAAHVG----YPLLVKPVAGADVP
MAV_4775|M.avium_104 RLAADELGLP-TAPFWFAGSLGELEAVGAHAG----YPLLVKPVVGAVGP
Mflv_0222|M.gilvum_PYR-GCK RLAADELGLP-TAPFWFAGTVEELTAIGQHAG----FPLVVKPVSGAPGE
Mvan_0685|M.vanbaalenii_PYR-1 RLAADELGLP-TAPFWFAGSVEELTAIVAHAG----FPMVVKPVAAAPGE
MSMEG_0766|M.smegmatis_MC2_155 RLASDELGLP-TVPFWFAGSVEELTAVAEHAG----YPLVVKPVTGSLRD
TH_1415|M.thermoresistible__bu RLAADELGLP-TAPFWFAGSVEELTAVAQHAG----FPLVVRPVTGPAGS
MAB_4245c|M.abscessus_ATCC_199 RMAAEELGLP-TPTYWFANSVEELRTVLETSG----FPAVVRPVAAAYGQ
MLBr_00735|M.leprae_Br4923 RLAALGAAMPRFMALDSVDDLAEIDAFAQRLTGSKDAPMVVKAVRGGYDG
MUL_2628|M.ulcerans_Agy99 RLQALDVPVPRYLGIHQLEELGELDAFARQL----DAPLVVKAVRGGYDG
:: : :* : *: :. * :* .* .
Mb0395|M.bovis_AF2122/97 GSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIEFLVTMIV
Rv0389|M.tuberculosis_H37Rv GSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIEFLVTMIV
MMAR_0686|M.marinum_M RRSLVRGPDEVEAAWARAVAG----GPAGAPPRVWAETQVEVEFLVTLIA
MAV_4775|M.avium_104 RQSVVAGREDIAAAWHRAVDG----QPG---ARVLAETVVEVQFHVMLLA
Mflv_0222|M.gilvum_PYR-GCK GESVLLRPEDVEPAWQRAVAAGAP-----TRRRVIAESVVEVDVEVTLLT
Mvan_0685|M.vanbaalenii_PYR-1 GESVLLRPDDVEPAWRHATAAGN-------LKRVIAETVVEVDFEVTLLT
MSMEG_0766|M.smegmatis_MC2_155 GQSVLLRPDDIEPAWKRATTAGHF-----AHSRVLAESVVEVDFEVTMLT
TH_1415|M.thermoresistible__bu GQSVLLREDDVEPAWHRAIAAGHF-----AQNRVMAETVVEIDYEVTMLT
MAB_4245c|M.abscessus_ATCC_199 GQSVVLRDGDVTPAWEQAIAANIG-----GGQRVMVETAVDIDYEITLLT
MLBr_00735|M.leprae_Br4923 RGVQMVR--DSAHAREVASGYLVD------GMPVLVEERVELRRELSALV
MUL_2628|M.ulcerans_Agy99 RGVQMAR--DLADARDIASGYLAG------GVPVLVEERVQLRRELSALV
: : * * * .* *:: : :.
Mb0395|M.bovis_AF2122/97 VCSQGPNGPL-IEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAAR
Rv0389|M.tuberculosis_H37Rv VCSQGPNGPL-IEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAAR
MMAR_0686|M.marinum_M VCSQGPQGPR-IDFCAPIGH-GGDGGDQESWQPQKVSVAALDAAKSIAAR
MAV_4775|M.avium_104 VRSEGAAGPA-IEFCSPIGHRGAGGRVLESWQPQKMSPAAMDAAKSIAAR
Mflv_0222|M.gilvum_PYR-GCK VRTAGPAGPT-VSFCEPIGHHQSPEGSLESWQPQQLSPVALDSAKSIAAR
Mvan_0685|M.vanbaalenii_PYR-1 VRTTGAAGPT-VHFCEPIGHHQNDDDALESWQPQQLSPTALDSAKSIAAR
MSMEG_0766|M.smegmatis_MC2_155 IRTTGPTGPG-VQFCEPIGHRRSDNGVLESWQPQQMPPAALDSAKSIAAR
TH_1415|M.thermoresistible__bu VRTTGPAGPT-IRFCEPIGHHHRNGEVLELWQPQQMSPVALDAAKSIAAR
MAB_4245c|M.abscessus_ATCC_199 VRTAGIGGATRLYFCEPIAHRQSGTDAMQMWQPQPLSQAALELARSIAAR
MLBr_00735|M.leprae_Br4923 ARSPFGQGAA---WPVVETVQRDGICVLVVAPALALADDLASAAQQLALR
MUL_2628|M.ulcerans_Agy99 ARSPFGQGAA---WPVVETVQQDGICVAVIAPAPALSAQAGADAQQLALR
: *. : . :. *:.:* *
Mb0395|M.bovis_AF2122/97 IVKALGGRGVFGVELMINGD-EVYFADVTVCPAGSAWVTVRSQRLSVFEL
Rv0389|M.tuberculosis_H37Rv IVKALGGRGVFGVELMINGD-EVYFADVTVCPAGSAWVTVRSQRLSVFEL
MMAR_0686|M.marinum_M IVKALGGCGVFGVELMVNGD-EVYFADVQPFPRDTAWVTLRSQRLSVFEL
MAV_4775|M.avium_104 IVKALGGRGVFGVELMVNDD-EVYFADVTAHPGDSAWVTVRSQRLSAFEL
Mflv_0222|M.gilvum_PYR-GCK IVNSLGGRGVFAVELLVRGD-EVYFSDVRPRLQDSGLVTLRSQRLSQFEL
Mvan_0685|M.vanbaalenii_PYR-1 IVNSLGGRGVFAVELLVRGD-EVYFSDVRPRLQDSGLVTLRSQRLSQFEL
MSMEG_0766|M.smegmatis_MC2_155 IVNSLGGRGVFGVELLVQGE-DVYFSDVRVRPHDSGLVTLRSQRLSEFEL
TH_1415|M.thermoresistible__bu IVNSLGGRGVYGVELLVRDD-EVYFSDVRVRPQDTGLVTLRSQRLSHFEL
MAB_4245c|M.abscessus_ATCC_199 AVNALGGHGVYGVELFVRGD-EVYFCDVSARPYDSGLVTVRSQRLSEYDM
MLBr_00735|M.leprae_Br4923 LAAELGVVGVFAVELFETADGALLVNELAMRPHNSGHWTMDGARTSQFEQ
MUL_2628|M.ulcerans_Agy99 LAAELGVVGVLAVELFETTDGALVVNELAMRPHNSGHWTMDGSRTSQFEQ
. ** ** .***: : : . :: .:. *: . * * ::
Mb0395|M.bovis_AF2122/97 QARATLGLAVDTLMISPGAARVINPDHTAGRAAV-GAAPPADALTGALGV
Rv0389|M.tuberculosis_H37Rv QARAILGLAVDTLMISPGAARVINPDHTAGRAAV-GAAPPADALTGALGV
MMAR_0686|M.marinum_M QARAILGFAVDTLMVSPGAARLI------GAATV-GPVPGADALAAALAV
MAV_4775|M.avium_104 QARTILGLPVDTMMVSPAAARVVD------SADP-GDR---AALSGALGV
Mflv_0222|M.gilvum_PYR-GCK HARAVLGLPVDTIMISPGAAEVTCS----------ADADARLVLGEALAV
Mvan_0685|M.vanbaalenii_PYR-1 HARAVLGLPVDTIMISPGAVEVSYPDGEGRAV---PDREIRAVLADALAV
MSMEG_0766|M.smegmatis_MC2_155 HARAILGLACDTIMISPGAAEVTYAGAEAAPS-----VDVTAVLGEALAT
TH_1415|M.thermoresistible__bu HARAILGLAVDTIMISPAAAEVHYGGSEAAWPGGTGGAELTAVLREALSV
MAB_4245c|M.abscessus_ATCC_199 HARAVLGAPVDTILVSPAAAEVVYGD---------GDGPSPRQLDQALQT
MLBr_00735|M.leprae_Br4923 HLRAVLDYPLGETDAVAPVTVMVNVLGAPQPPTLSVVTMDERLHHLFARM
MUL_2628|M.ulcerans_Agy99 HLRAVLDYPLGDTEAIAPVTVMTNVLGAAAQPAMS---LDERLHHLFARM
: *: *. . . . .. :
Mb0395|M.bovis_AF2122/97 PESDVVIFGRG----------LGVALAT-APEVAIARERAREVASRLNVP
Rv0389|M.tuberculosis_H37Rv PESDVVIFGRG----------LGVALAT-APEVAIARERAREVASRLNVP
MMAR_0686|M.marinum_M PESDVRVFGRPRA----GSSVLGVALAT-APDVAVARDRAREVVDRLNVR
MAV_4775|M.avium_104 PESDLRVCGRG-----------FRALAT-APEVAAARERAGQVAARLTAG
Mflv_0222|M.gilvum_PYR-GCK AESDVRVLRSEPP--------VRVSLAT-APDPIVARDRARRVASALRRS
Mvan_0685|M.vanbaalenii_PYR-1 AESDVRLFPATAAGDDDDVPWLSWSTAT-AQDPIVARDRARRVATAVRRL
MSMEG_0766|M.smegmatis_MC2_155 SESDVRLFG-RAE-ESDDGRRLGVALAT-APDVIVARDRARRVGTALRRL
TH_1415|M.thermoresistible__bu PESDVRLFG-GPDDETDAPHRLGVALAT-APDATAARRQVRQVSTALRRL
MAB_4245c|M.abscessus_ATCC_199 PESDLRVFGHTEAHR---RRRVAVALAT-APNTALALNRAQQVARHLR--
MLBr_00735|M.leprae_Br4923 PDARVHLYDKVERPGRKVGHINFRGTDKDRKNPTKLRERAELAAHWLSHG
MUL_2628|M.ulcerans_Agy99 PDARVHLYGKDERPGRKVGHINFLGFDP--AAVAGLRERAELAAHWLSHG
.:: : : . :. . :
Mb0395|M.bovis_AF2122/97 DSRE----------------------------
Rv0389|M.tuberculosis_H37Rv DSRE----------------------------
MMAR_0686|M.marinum_M DSRG----------------------------
MAV_4775|M.avium_104 AGGVGGAGG-----------------------
Mflv_0222|M.gilvum_PYR-GCK V-------------------------------
Mvan_0685|M.vanbaalenii_PYR-1 R-------------------------------
MSMEG_0766|M.smegmatis_MC2_155 W-------------------------------
TH_1415|M.thermoresistible__bu W-------------------------------
MAB_4245c|M.abscessus_ATCC_199 --------------------------------
MLBr_00735|M.leprae_Br4923 QWTDGWDPHRAGDDVVEISLACGGRNDAQRQR
MUL_2628|M.ulcerans_Agy99 QWTDGWDPHG----------------------