For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TDGRDDETTALAVPRPAPAEGGPAPADGGPAPADGRPAVMLLGSGDISRELAIALGRLGARVIAVDAHPQ APAHAVADQALVLPLTDAGELSAAIHRLRPDVVVSTTDAVAVPALEALDGTGAEPVPSARAVRLAADREG LRRLAADELGLPTAPFWFAGSLGELEAVGAHAGYPLLVKPVVGAVGPRQSVVAGREDIAAAWHRAVDGQP GARVLAETVVEVQFHVMLLAVRSEGAAGPAIEFCSPIGHRGAGGRVLESWQPQKMSPAAMDAAKSIAARI VKALGGRGVFGVELMVNDDEVYFADVTAHPGDSAWVTVRSQRLSAFELQARTILGLPVDTMMVSPAAARV VDSADPGDRAALSGALGVPESDLRVCGRGFRALATAPEVAAARERAGQVAARLTAGAGGVGGAGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4775 | purT | - | 100% (416) | phosphoribosylglycinamide formyltransferase 2 |
| M. avium 104 | MAV_4245 | purK | 4e-15 | 29.84% (315) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
| M. avium 104 | MAV_3389 | carB | 7e-10 | 22.86% (398) | carbamoyl phosphate synthase large subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0395 | purT | 1e-126 | 64.12% (393) | phosphoribosylglycinamide formyltransferase 2 |
| M. gilvum PYR-GCK | Mflv_0222 | - | 4e-92 | 52.39% (376) | ATP-dependent carboxylate-amine ligase domain-containing |
| M. tuberculosis H37Rv | Rv0389 | purT | 1e-127 | 64.38% (393) | phosphoribosylglycinamide formyltransferase 2 |
| M. leprae Br4923 | MLBr_00735 | purK | 6e-15 | 28.83% (333) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
| M. abscessus ATCC 19977 | MAB_4245c | - | 4e-97 | 48.57% (420) | phosphoribosylglycinamide formyltransferase 2 |
| M. marinum M | MMAR_0686 | purT | 1e-125 | 62.11% (417) | formate-dependent phosphoribosylglycinamide |
| M. smegmatis MC2 155 | MSMEG_0766 | purT | 1e-105 | 51.60% (438) | phosphoribosylglycinamide formyltransferase 2 |
| M. thermoresistible (build 8) | TH_1415 | purT | 1e-112 | 53.86% (440) | PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT |
| M. ulcerans Agy99 | MUL_2628 | purK | 4e-14 | 30.15% (335) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
| M. vanbaalenii PYR-1 | Mvan_0685 | - | 2e-87 | 49.87% (381) | ATP-dependent carboxylate-amine ligase domain-containing |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0395|M.bovis_AF2122/97 --------------------------------------------------
Rv0389|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0686|M.marinum_M --------------------------------------------------
MAV_4775|M.avium_104 --------------------------------------------------
MSMEG_0766|M.smegmatis_MC2_155 ------------------------------------MSESIEGALTDDAA
TH_1415|M.thermoresistible__bu --------------------------------------------------
Mflv_0222|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0685|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4245c|M.abscessus_ATCC_199 MNGIVVTQEGSPPSEQGTATSADIVEPVPAAAAPVTEEAVRATNGAKSGS
MLBr_00735|M.leprae_Br4923 --------------------------------------------------
MUL_2628|M.ulcerans_Agy99 --------------------------------------------------
Mb0395|M.bovis_AF2122/97 ----------------------------MIDGWTEGQHEPTVRHERPAAP
Rv0389|M.tuberculosis_H37Rv ----------------------------MIDGWTEEQHEPTVRHERPAAP
MMAR_0686|M.marinum_M ----------------------------MTDGLTEGHDEAIGKHQRPATE
MAV_4775|M.avium_104 ----------------------------MTDGRDDETTALAVPRPAPAEG
MSMEG_0766|M.smegmatis_MC2_155 ADESAGAGPDDTDVTDDSVADTAPEDTAPDPDDTEPGDRAAADQETDTDP
TH_1415|M.thermoresistible__bu -------------VTDPATDPTAEQATDPVAEAAGPGGEPKLQAGAPVDD
Mflv_0222|M.gilvum_PYR-GCK --------------------------------------------MTEMET
Mvan_0685|M.vanbaalenii_PYR-1 --------------------------------------------MSDTN-
MAB_4245c|M.abscessus_ATCC_199 KTAKAATPVEAVGKTVEAGAPAPEAVADLAEGHTEDRTGQAVPQPPEAPA
MLBr_00735|M.leprae_Br4923 ------------------------------------------MMAVPSRC
MUL_2628|M.ulcerans_Agy99 ----------------------MIHNDLVLQPPNTPVMGHDTMMAVPS--
Mb0395|M.bovis_AF2122/97 ---------------------------QDVR-RVMLLGSAEPSRELAIAL
Rv0389|M.tuberculosis_H37Rv ---------------------------QDVR-RVMLLGSAEPSRELAIAL
MMAR_0686|M.marinum_M GANAPEGDKTTTIAVPPVGTPRRAEADVHVRPRVVLLGGGEQGRELTIAL
MAV_4775|M.avium_104 GPAPADG----------------GPAPADGRPAVMLLGSGDISRELAIAL
MSMEG_0766|M.smegmatis_MC2_155 EPQPVVGPD-----------------AADHRPTVMLLGGGALSRELALAF
TH_1415|M.thermoresistible__bu EPAAQAEP------------------ARPARPTVMLLGAGELSRELVLAF
Mflv_0222|M.gilvum_PYR-GCK --------------------------AHEGRTVVLLLGAGERTRELAPAF
Mvan_0685|M.vanbaalenii_PYR-1 ------------------------------GETVLLLGAGERSSELALAF
MAB_4245c|M.abscessus_ATCC_199 PADLPADEAEP---------------PAGNRTTVMLLGSGELAKELAISF
MLBr_00735|M.leprae_Br4923 --------------------------SLGVAPLVAMVGGGQLARMTHQAA
MUL_2628|M.ulcerans_Agy99 ----------------------------SRTPQVAMVGGGQLARMTHQAA
* ::*.. :
Mb0395|M.bovis_AF2122/97 QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVT
Rv0389|M.tuberculosis_H37Rv QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVT
MMAR_0686|M.marinum_M QGLGAEVIAVDTDADAPAHRVADQALVVAMTDADELKVVFTRLRPDFVVP
MAV_4775|M.avium_104 GRLGARVIAVDAHPQAPAHAVADQALVLPLTDAGELSAAIHRLRPDVVVS
MSMEG_0766|M.smegmatis_MC2_155 QNLGGVVVAVDRY-DAPAHGVADRTAVVDLNDADELSAVIAREKPQYVVA
TH_1415|M.thermoresistible__bu QRLGAEVVAVDRYADAPAYPVADRSVVATMSDADALTAVIEREAPQYVVA
Mflv_0222|M.gilvum_PYR-GCK EHLGAQVVTADAA-----------------ADAQTLTALIEQHAARYVVA
Mvan_0685|M.vanbaalenii_PYR-1 RHLGADVVTVSDH-----------------GETQALTALIDERRPRYVVA
MAB_4245c|M.abscessus_ATCC_199 QRLGAEVIVVDTGKGGPAQGVADRAVLAPIGESERLYELIEKERPRFVVP
MLBr_00735|M.leprae_Br4923 IALGQTLRVLATAADEPAAQVTPDVVIGSHTDLEDLRRVALGADALTFDH
MUL_2628|M.ulcerans_Agy99 IALGQNLRVLVNSADDPAAQVTPNVVIGSHTDLDDLRRIAAGADVVTFDH
** : . : * .
Mb0395|M.bovis_AF2122/97 VTA------AVSVDALDAVEQ---ADGECTELVPNARAVRCTADREGLR-
Rv0389|M.tuberculosis_H37Rv VTA------AVSVDALDAVEQ---ADGECTELVPNARAVRCTADREGLR-
MMAR_0686|M.marinum_M LTD------AVSVAALDALADRAPSEGGSIGLVPSARCVRLAGDREALR-
MAV_4775|M.avium_104 TTD------AVAVPALEALDG------TGAEPVPSARAVRLAADREGLR-
MSMEG_0766|M.smegmatis_MC2_155 AESG-----VIAADALIAAAE-----RGDSEVLPTPRSIRLSQNREGLR-
TH_1415|M.thermoresistible__bu EST------AVAVDALIAVAE-----RGSVEVFPTPRAIRLSYDREGLR-
Mflv_0222|M.gilvum_PYR-GCK DLDTAEATNVATTGALHAIAD-----RDDVEVFPTLRSIRFALDGEALR-
Mvan_0685|M.vanbaalenii_PYR-1 D-----AATVATD-ALIAVAE-----RDDVEVFPTPRATRLSLDGEGLR-
MAB_4245c|M.abscessus_ATCC_199 LVE------AASREALDKLAEG-----EVTQVIPTAKAVRLAGDREGMR-
MLBr_00735|M.leprae_Br4923 EH--------VPTELLDKLVA------EGINVAPSPQALVHAQDKLVMRR
MUL_2628|M.ulcerans_Agy99 EH--------VPAELLDKLVA------EGVVLAPPPQALVHAQDKLVMRR
. * * :. : : :*
Mb0395|M.bovis_AF2122/97 RLAADQLGLP-TAPFWFVGSLGELQAVAVHAG----FPLLVSPVAGVAGQ
Rv0389|M.tuberculosis_H37Rv RLAADQLGLP-TAPFWFVGSLGELQAVAVHAG----FPLLVSPVAGVAGQ
MMAR_0686|M.marinum_M KLAADQLGLP-TAPFWFVGSLGELEAVAAHVG----YPLLVKPVAGADVP
MAV_4775|M.avium_104 RLAADELGLP-TAPFWFAGSLGELEAVGAHAG----YPLLVKPVVGAVGP
MSMEG_0766|M.smegmatis_MC2_155 RLASDELGLP-TVPFWFAGSVEELTAVAEHAG----YPLVVKPVTGSLRD
TH_1415|M.thermoresistible__bu RLAADELGLP-TAPFWFAGSVEELTAVAQHAG----FPLVVRPVTGPAGS
Mflv_0222|M.gilvum_PYR-GCK RLAADELGLP-TAPFWFAGTVEELTAIGQHAG----FPLVVKPVSGAPGE
Mvan_0685|M.vanbaalenii_PYR-1 RLAADELGLP-TAPFWFAGSVEELTAIVAHAG----FPMVVKPVAAAPGE
MAB_4245c|M.abscessus_ATCC_199 RMAAEELGLP-TPTYWFANSVEELRTVLETSG----FPAVVRPVAAAYGQ
MLBr_00735|M.leprae_Br4923 RLAALGAAMPRFMALDSVDDLAEIDAFAQRLTGSKDAPMVVKAVRGGYDG
MUL_2628|M.ulcerans_Agy99 RLQALDVPVPRYLGIHQLEELGELDAFARQL----DAPLVVKAVRGGYDG
:: : :* : *: :. * :* .* .
Mb0395|M.bovis_AF2122/97 GSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIEFLVTMIV
Rv0389|M.tuberculosis_H37Rv GSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIEFLVTMIV
MMAR_0686|M.marinum_M RRSLVRGPDEVEAAWARAVAG----GPAGAPPRVWAETQVEVEFLVTLIA
MAV_4775|M.avium_104 RQSVVAGREDIAAAWHRAVDG----QPG---ARVLAETVVEVQFHVMLLA
MSMEG_0766|M.smegmatis_MC2_155 GQSVLLRPDDIEPAWKRATTAGHF-----AHSRVLAESVVEVDFEVTMLT
TH_1415|M.thermoresistible__bu GQSVLLREDDVEPAWHRAIAAGHF-----AQNRVMAETVVEIDYEVTMLT
Mflv_0222|M.gilvum_PYR-GCK GESVLLRPEDVEPAWQRAVAAGAP-----TRRRVIAESVVEVDVEVTLLT
Mvan_0685|M.vanbaalenii_PYR-1 GESVLLRPDDVEPAWRHATAAGN-------LKRVIAETVVEVDFEVTLLT
MAB_4245c|M.abscessus_ATCC_199 GQSVVLRDGDVTPAWEQAIAANIG-----GGQRVMVETAVDIDYEITLLT
MLBr_00735|M.leprae_Br4923 RGVQMVR--DSAHAREVASGYLVD------GMPVLVEERVELRRELSALV
MUL_2628|M.ulcerans_Agy99 RGVQMAR--DLADARDIASGYLAG------GVPVLVEERVQLRRELSALV
: : * * * .* *:: : :.
Mb0395|M.bovis_AF2122/97 VCSQGPNGPL-IEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAAR
Rv0389|M.tuberculosis_H37Rv VCSQGPNGPL-IEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAAR
MMAR_0686|M.marinum_M VCSQGPQGPR-IDFCAPIGH-GGDGGDQESWQPQKVSVAALDAAKSIAAR
MAV_4775|M.avium_104 VRSEGAAGPA-IEFCSPIGHRGAGGRVLESWQPQKMSPAAMDAAKSIAAR
MSMEG_0766|M.smegmatis_MC2_155 IRTTGPTGPG-VQFCEPIGHRRSDNGVLESWQPQQMPPAALDSAKSIAAR
TH_1415|M.thermoresistible__bu VRTTGPAGPT-IRFCEPIGHHHRNGEVLELWQPQQMSPVALDAAKSIAAR
Mflv_0222|M.gilvum_PYR-GCK VRTAGPAGPT-VSFCEPIGHHQSPEGSLESWQPQQLSPVALDSAKSIAAR
Mvan_0685|M.vanbaalenii_PYR-1 VRTTGAAGPT-VHFCEPIGHHQNDDDALESWQPQQLSPTALDSAKSIAAR
MAB_4245c|M.abscessus_ATCC_199 VRTAGIGGATRLYFCEPIAHRQSGTDAMQMWQPQPLSQAALELARSIAAR
MLBr_00735|M.leprae_Br4923 ARSPFGQGAA---WPVVETVQRDGICVLVVAPALALADDLASAAQQLALR
MUL_2628|M.ulcerans_Agy99 ARSPFGQGAA---WPVVETVQQDGICVAVIAPAPALSAQAGADAQQLALR
: *. : . :. *:.:* *
Mb0395|M.bovis_AF2122/97 IVKALGGRGVFGVELMINGD-EVYFADVTVCPAGSAWVTVRSQRLSVFEL
Rv0389|M.tuberculosis_H37Rv IVKALGGRGVFGVELMINGD-EVYFADVTVCPAGSAWVTVRSQRLSVFEL
MMAR_0686|M.marinum_M IVKALGGCGVFGVELMVNGD-EVYFADVQPFPRDTAWVTLRSQRLSVFEL
MAV_4775|M.avium_104 IVKALGGRGVFGVELMVNDD-EVYFADVTAHPGDSAWVTVRSQRLSAFEL
MSMEG_0766|M.smegmatis_MC2_155 IVNSLGGRGVFGVELLVQGE-DVYFSDVRVRPHDSGLVTLRSQRLSEFEL
TH_1415|M.thermoresistible__bu IVNSLGGRGVYGVELLVRDD-EVYFSDVRVRPQDTGLVTLRSQRLSHFEL
Mflv_0222|M.gilvum_PYR-GCK IVNSLGGRGVFAVELLVRGD-EVYFSDVRPRLQDSGLVTLRSQRLSQFEL
Mvan_0685|M.vanbaalenii_PYR-1 IVNSLGGRGVFAVELLVRGD-EVYFSDVRPRLQDSGLVTLRSQRLSQFEL
MAB_4245c|M.abscessus_ATCC_199 AVNALGGHGVYGVELFVRGD-EVYFCDVSARPYDSGLVTVRSQRLSEYDM
MLBr_00735|M.leprae_Br4923 LAAELGVVGVFAVELFETADGALLVNELAMRPHNSGHWTMDGARTSQFEQ
MUL_2628|M.ulcerans_Agy99 LAAELGVVGVLAVELFETTDGALVVNELAMRPHNSGHWTMDGSRTSQFEQ
. ** ** .***: : : . :: .:. *: . * * ::
Mb0395|M.bovis_AF2122/97 QARATLGLAVDTLMISPGAARVINPDHTAGRAAV-GAAPPADALTGALGV
Rv0389|M.tuberculosis_H37Rv QARAILGLAVDTLMISPGAARVINPDHTAGRAAV-GAAPPADALTGALGV
MMAR_0686|M.marinum_M QARAILGFAVDTLMVSPGAARLI------GAATV-GPVPGADALAAALAV
MAV_4775|M.avium_104 QARTILGLPVDTMMVSPAAARVVD------SADP-GDR---AALSGALGV
MSMEG_0766|M.smegmatis_MC2_155 HARAILGLACDTIMISPGAAEVTYAGAEAAPS-----VDVTAVLGEALAT
TH_1415|M.thermoresistible__bu HARAILGLAVDTIMISPAAAEVHYGGSEAAWPGGTGGAELTAVLREALSV
Mflv_0222|M.gilvum_PYR-GCK HARAVLGLPVDTIMISPGAAEVTCS----------ADADARLVLGEALAV
Mvan_0685|M.vanbaalenii_PYR-1 HARAVLGLPVDTIMISPGAVEVSYPDGEGRAV---PDREIRAVLADALAV
MAB_4245c|M.abscessus_ATCC_199 HARAVLGAPVDTILVSPAAAEVVYGD---------GDGPSPRQLDQALQT
MLBr_00735|M.leprae_Br4923 HLRAVLDYPLGETDAVAPVTVMVNVLGAPQPPTLSVVTMDERLHHLFARM
MUL_2628|M.ulcerans_Agy99 HLRAVLDYPLGDTEAIAPVTVMTNVLGAAAQPAMS---LDERLHHLFARM
: *: *. . . . .. :
Mb0395|M.bovis_AF2122/97 PESDVVIFGRG----------LGVALAT-APEVAIARERAREVASRLNVP
Rv0389|M.tuberculosis_H37Rv PESDVVIFGRG----------LGVALAT-APEVAIARERAREVASRLNVP
MMAR_0686|M.marinum_M PESDVRVFGRPRA----GSSVLGVALAT-APDVAVARDRAREVVDRLNVR
MAV_4775|M.avium_104 PESDLRVCGRG-----------FRALAT-APEVAAARERAGQVAARLTAG
MSMEG_0766|M.smegmatis_MC2_155 SESDVRLFG-RAE-ESDDGRRLGVALAT-APDVIVARDRARRVGTALRRL
TH_1415|M.thermoresistible__bu PESDVRLFG-GPDDETDAPHRLGVALAT-APDATAARRQVRQVSTALRRL
Mflv_0222|M.gilvum_PYR-GCK AESDVRVLRSEPP--------VRVSLAT-APDPIVARDRARRVASALRRS
Mvan_0685|M.vanbaalenii_PYR-1 AESDVRLFPATAAGDDDDVPWLSWSTAT-AQDPIVARDRARRVATAVRRL
MAB_4245c|M.abscessus_ATCC_199 PESDLRVFGHTEAHR---RRRVAVALAT-APNTALALNRAQQVARHLR--
MLBr_00735|M.leprae_Br4923 PDARVHLYDKVERPGRKVGHINFRGTDKDRKNPTKLRERAELAAHWLSHG
MUL_2628|M.ulcerans_Agy99 PDARVHLYGKDERPGRKVGHINFLGFDP--AAVAGLRERAELAAHWLSHG
.:: : : . :. . :
Mb0395|M.bovis_AF2122/97 DSRE----------------------------
Rv0389|M.tuberculosis_H37Rv DSRE----------------------------
MMAR_0686|M.marinum_M DSRG----------------------------
MAV_4775|M.avium_104 AGGVGGAGG-----------------------
MSMEG_0766|M.smegmatis_MC2_155 W-------------------------------
TH_1415|M.thermoresistible__bu W-------------------------------
Mflv_0222|M.gilvum_PYR-GCK V-------------------------------
Mvan_0685|M.vanbaalenii_PYR-1 R-------------------------------
MAB_4245c|M.abscessus_ATCC_199 --------------------------------
MLBr_00735|M.leprae_Br4923 QWTDGWDPHRAGDDVVEISLACGGRNDAQRQR
MUL_2628|M.ulcerans_Agy99 QWTDGWDPHG----------------------