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NGIVVTQEGSPPSEQGTATSADIVEPVPAAAAPVTEEAVRATNGAKSGSKTAKAATPVEAVGKTVEAGAP APEAVADLAEGHTEDRTGQAVPQPPEAPAPADLPADEAEPPAGNRTTVMLLGSGELAKELAISFQRLGAE VIVVDTGKGGPAQGVADRAVLAPIGESERLYELIEKERPRFVVPLVEAASREALDKLAEGEVTQVIPTAK AVRLAGDREGMRRMAAEELGLPTPTYWFANSVEELRTVLETSGFPAVVRPVAAAYGQGQSVVLRDGDVTP AWEQAIAANIGGGQRVMVETAVDIDYEITLLTVRTAGIGGATRLYFCEPIAHRQSGTDAMQMWQPQPLSQ AALELARSIAARAVNALGGHGVYGVELFVRGDEVYFCDVSARPYDSGLVTVRSQRLSEYDMHARAVLGAP VDTILVSPAAAEVVYGDGDGPSPRQLDQALQTPESDLRVFGHTEAHRRRRVAVALATAPNTALALNRAQQ VARHLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4245c | - | - | 100% (497) | phosphoribosylglycinamide formyltransferase 2 |
| M. abscessus ATCC 19977 | MAB_1191c | purT | 7e-91 | 45.04% (393) | phosphoribosylglycinamide formyltransferase 2 |
| M. abscessus ATCC 19977 | MAB_3620c | - | 3e-14 | 25.14% (362) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0395 | purT | 1e-90 | 45.97% (409) | phosphoribosylglycinamide formyltransferase 2 |
| M. gilvum PYR-GCK | Mflv_2039 | purT | 2e-96 | 49.35% (387) | phosphoribosylglycinamide formyltransferase 2 |
| M. tuberculosis H37Rv | Rv0389 | purT | 5e-91 | 45.97% (409) | phosphoribosylglycinamide formyltransferase 2 |
| M. leprae Br4923 | MLBr_00735 | purK | 1e-14 | 27.96% (329) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
| M. marinum M | MMAR_0686 | purT | 1e-88 | 45.54% (437) | formate-dependent phosphoribosylglycinamide |
| M. avium 104 | MAV_4775 | purT | 5e-97 | 48.57% (420) | phosphoribosylglycinamide formyltransferase 2 |
| M. smegmatis MC2 155 | MSMEG_0766 | purT | 1e-102 | 45.63% (458) | phosphoribosylglycinamide formyltransferase 2 |
| M. thermoresistible (build 8) | TH_1415 | purT | 1e-115 | 51.25% (439) | PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT |
| M. ulcerans Agy99 | MUL_2628 | purK | 2e-16 | 28.10% (420) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
| M. vanbaalenii PYR-1 | Mvan_0685 | - | 2e-97 | 50.26% (392) | ATP-dependent carboxylate-amine ligase domain-containing |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0395|M.bovis_AF2122/97 -----------------------------------------MIDGWTEG-
Rv0389|M.tuberculosis_H37Rv -----------------------------------------MIDGWTEE-
MMAR_0686|M.marinum_M -----------------------------------------MTDGLTEG-
MAV_4775|M.avium_104 -----------------------------------------MTDGRDDE-
MSMEG_0766|M.smegmatis_MC2_155 --------------------------------MSESIEGALTDDAAADES
Mvan_0685|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1415|M.thermoresistible__bu -----------------------------------------VTDPATDPT
MAB_4245c|M.abscessus_ATCC_199 MNGIVVTQEGSPPSEQGTATSADIVEPVPAAAAPVTEEAVRATNGAKSGS
Mflv_2039|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_00735|M.leprae_Br4923 --------------------------------------------------
MUL_2628|M.ulcerans_Agy99 ---------------------------------------------MIHND
Mb0395|M.bovis_AF2122/97 --------------QHEPTVRHERPAAP----------------------
Rv0389|M.tuberculosis_H37Rv --------------QHEPTVRHERPAAP----------------------
MMAR_0686|M.marinum_M --------------HDEAIGKHQRPATEGANAPEGDKTTTIAVPPVGT-P
MAV_4775|M.avium_104 --------------TTALAVPRPAPAEGGPAPADG---------------
MSMEG_0766|M.smegmatis_MC2_155 AGAGPDDTDVTDDSVADTAPEDTAPDPDDTEPGDRAAADQETDTDPEPQP
Mvan_0685|M.vanbaalenii_PYR-1 ----------------------------------------MSDTN-----
TH_1415|M.thermoresistible__bu AEQATDP-------VAEAAGPGGEPKLQAGAPVDDEPAAQAEPARP----
MAB_4245c|M.abscessus_ATCC_199 KTAKAATPVEAVGKTVEAGAPAPEAVADLAEGHTEDRTGQAVPQPPEAPA
Mflv_2039|M.gilvum_PYR-GCK ---------------MTTIGTPLSPRAT----------------------
MLBr_00735|M.leprae_Br4923 ---------------MMAVPSRCS--------------------------
MUL_2628|M.ulcerans_Agy99 LVLQPPNTPVMGHDTMMAVPS-----------------------------
Mb0395|M.bovis_AF2122/97 ------------QDVR-RVMLLGSAEPSRELAIALQGLGAEVIAVDGYVG
Rv0389|M.tuberculosis_H37Rv ------------QDVR-RVMLLGSAEPSRELAIALQGLGAEVIAVDGYVG
MMAR_0686|M.marinum_M ------RRAEADVHVRPRVVLLGGGEQGRELTIALQGLGAEVIAVDTDAD
MAV_4775|M.avium_104 --------GPAPADGRPAVMLLGSGDISRELAIALGRLGARVIAVDAHPQ
MSMEG_0766|M.smegmatis_MC2_155 ------VVGPDAADHRPTVMLLGGGALSRELALAFQNLGGVVVAVDRY-D
Mvan_0685|M.vanbaalenii_PYR-1 ---------------GETVLLLGAGERSSELALAFRHLG-----------
TH_1415|M.thermoresistible__bu --------------ARPTVMLLGAGELSRELVLAFQRLGAEVVAVDRYAD
MAB_4245c|M.abscessus_ATCC_199 PADLPADEAEPPAGNRTTVMLLGSGELAKELAISFQRLGAEVIVVDTGKG
Mflv_2039|M.gilvum_PYR-GCK -----------------KVMLLGSGELGREVLIALQRLGVETIAVDRYDN
MLBr_00735|M.leprae_Br4923 ------------LGVAPLVAMVGGGQLARMTHQAAIALGQTLRVLATAAD
MUL_2628|M.ulcerans_Agy99 -------------SRTPQVAMVGGGQLARMTHQAAIALGQNLRVLVNSAD
* ::*.. . : **
Mb0395|M.bovis_AF2122/97 APAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVTVTA-AVSVDALDAVE
Rv0389|M.tuberculosis_H37Rv APAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVTVTA-AVSVDALDAVE
MMAR_0686|M.marinum_M APAHRVADQALVVAMTDADELKVVFTRLRPDFVVPLTD-AVSVAALDALA
MAV_4775|M.avium_104 APAHAVADQALVLPLTDAGELSAAIHRLRPDVVVSTTD-AVAVPALEALD
MSMEG_0766|M.smegmatis_MC2_155 APAHGVADRTAVVDLNDADELSAVIAREKPQYVVAAESGVIAADALIAAA
Mvan_0685|M.vanbaalenii_PYR-1 ------ADVVTVSDHGETQALTALIDERRPRYVVADAA-TVATDALIAVA
TH_1415|M.thermoresistible__bu APAYPVADRSVVATMSDADALTAVIEREAPQYVVAEST-AVAVDALIAVA
MAB_4245c|M.abscessus_ATCC_199 GPAQGVADRAVLAPIGESERLYELIEKERPRFVVPLVE-AASREALDKLA
Mflv_2039|M.gilvum_PYR-GCK APGQQVAHHARTIAMTDPEQLRALIEAERPDLVVPEIE-AIATPALEALE
MLBr_00735|M.leprae_Br4923 EPAAQVTPDVVIGSHTDLEDLRRVALG---ADALTFDHEHVPTELLDKLV
MUL_2628|M.ulcerans_Agy99 DPAAQVTPNVVIGSHTDLDDLRRIAAG---ADVVTFDHEHVPAELLDKLV
: : * :. . *
Mb0395|M.bovis_AF2122/97 Q---ADGECTELVPNARAVRCTADREGLRRLAADQLGLPTAPFWFVGSLG
Rv0389|M.tuberculosis_H37Rv Q---ADGECTELVPNARAVRCTADREGLRRLAADQLGLPTAPFWFVGSLG
MMAR_0686|M.marinum_M DRAPSEGGSIGLVPSARCVRLAGDREALRKLAADQLGLPTAPFWFVGSLG
MAV_4775|M.avium_104 G------TGAEPVPSARAVRLAADREGLRRLAADELGLPTAPFWFAGSLG
MSMEG_0766|M.smegmatis_MC2_155 E-----RGDSEVLPTPRSIRLSQNREGLRRLASDELGLPTVPFWFAGSVE
Mvan_0685|M.vanbaalenii_PYR-1 E-----RDDVEVFPTPRATRLSLDGEGLRRLAADELGLPTAPFWFAGSVE
TH_1415|M.thermoresistible__bu E-----RGSVEVFPTPRAIRLSYDREGLRRLAADELGLPTAPFWFAGSVE
MAB_4245c|M.abscessus_ATCC_199 EG-----EVTQVIPTAKAVRLAGDREGMRRMAAEELGLPTPTYWFANSVE
Mflv_2039|M.gilvum_PYR-GCK A-----EGVVTVIPTARAARLTMDREGIRRLAAETLGLPTSPYRFCDSLE
MLBr_00735|M.leprae_Br4923 A------EGINVAPSPQALVHAQDKLVMRR-RLAALGAAMPRFMALDSVD
MUL_2628|M.ulcerans_Agy99 A------EGVVLAPPPQALVHAQDKLVMRR-RLQALDVPVPRYLGIHQLE
* .:. : : :*: *. . : .:
Mb0395|M.bovis_AF2122/97 ELQAVAV-------HAGFPLLVSPVAGVA-GQGSSVVAGPNEVEPAWQRA
Rv0389|M.tuberculosis_H37Rv ELQAVAV-------HAGFPLLVSPVAGVA-GQGSSVVAGPNEVEPAWQRA
MMAR_0686|M.marinum_M ELEAVAA-------HVGYPLLVKPVAGAD-VPRRSLVRGPDEVEAAWARA
MAV_4775|M.avium_104 ELEAVGA-------HAGYPLLVKPVVGAV-GPRQSVVAGREDIAAAWHRA
MSMEG_0766|M.smegmatis_MC2_155 ELTAVAE-------HAGYPLVVKPVTGSL-RDGQSVLLRPDDIEPAWKRA
Mvan_0685|M.vanbaalenii_PYR-1 ELTAIVA-------HAGFPMVVKPVAAAP-GEGESVLLRPDDVEPAWRHA
TH_1415|M.thermoresistible__bu ELTAVAQ-------HAGFPLVVRPVTGPA-GSGQSVLLREDDVEPAWHRA
MAB_4245c|M.abscessus_ATCC_199 ELRTVLE-------TSGFPAVVRPVAAAY-GQGQSVVLRDGDVTPAWEQA
Mflv_2039|M.gilvum_PYR-GCK ELRAAIDG------TVGYPCVVKPVMSSS-GKGQSKIDGPEDVAPAWEYA
MLBr_00735|M.leprae_Br4923 DLAEIDAFAQRLTGSKDAPMVVKAVRGGYDGRGVQMVRDSAHAREVASGY
MUL_2628|M.ulcerans_Agy99 ELGELDAFARQL----DAPLVVKAVRGGYDGRGVQMARDLADARDIASGY
:* . * :* .* . . .
Mb0395|M.bovis_AF2122/97 AGHQVQPQTGGVSPRVCAESVVEIEFLVTMIVVCSQGPNGPL-IEFCAPI
Rv0389|M.tuberculosis_H37Rv AGHQVQPQTGGVSPRVCAESVVEIEFLVTMIVVCSQGPNGPL-IEFCAPI
MMAR_0686|M.marinum_M VAG----GPAGAPPRVWAETQVEVEFLVTLIAVCSQGPQGPR-IDFCAPI
MAV_4775|M.avium_104 VDG----QPG---ARVLAETVVEVQFHVMLLAVRSEGAAGPA-IEFCSPI
MSMEG_0766|M.smegmatis_MC2_155 TTAG-----HFAHSRVLAESVVEVDFEVTMLTIRTTGPTGPG-VQFCEPI
Mvan_0685|M.vanbaalenii_PYR-1 TAAG-----NLK--RVIAETVVEVDFEVTLLTVRTTGAAGPT-VHFCEPI
TH_1415|M.thermoresistible__bu IAAG-----HFAQNRVMAETVVEIDYEVTMLTVRTTGPAGPT-IRFCEPI
MAB_4245c|M.abscessus_ATCC_199 IAAN-----IGGGQRVMVETAVDIDYEITLLTVRTAGIGGATRLYFCEPI
Mflv_2039|M.gilvum_PYR-GCK MSGS-----RVSNTRIIVEGFVDFDYEITLLTVRARGASGEVQTQFCEPI
MLBr_00735|M.leprae_Br4923 LVDG---------MPVLVEERVELRRELSALVARSPFGQGAA----WPVV
MUL_2628|M.ulcerans_Agy99 LAGG---------VPVLVEERVQLRRELSALVARSPFGQGAA----WPVV
: .* *:. : :. : * :
Mb0395|M.bovis_AF2122/97 GHRDADAGELESWQPQ-KLSTAALDAAKSIAARIVKALGGRGVFGVELMI
Rv0389|M.tuberculosis_H37Rv GHRDADAGELESWQPQ-KLSTAALDAAKSIAARIVKALGGRGVFGVELMI
MMAR_0686|M.marinum_M GH-GGDGGDQESWQPQ-KVSVAALDAAKSIAARIVKALGGCGVFGVELMV
MAV_4775|M.avium_104 GHRGAGGRVLESWQPQ-KMSPAAMDAAKSIAARIVKALGGRGVFGVELMV
MSMEG_0766|M.smegmatis_MC2_155 GHRRSDNGVLESWQPQ-QMPPAALDSAKSIAARIVNSLGGRGVFGVELLV
Mvan_0685|M.vanbaalenii_PYR-1 GHHQNDDDALESWQPQ-QLSPTALDSAKSIAARIVNSLGGRGVFAVELLV
TH_1415|M.thermoresistible__bu GHHHRNGEVLELWQPQ-QMSPVALDAAKSIAARIVNSLGGRGVYGVELLV
MAB_4245c|M.abscessus_ATCC_199 AHRQSGTDAMQMWQPQ-PLSQAALELARSIAARAVNALGGHGVYGVELFV
Mflv_2039|M.gilvum_PYR-GCK GHRQVSGDYVESWQPH-PMPSTALDRSRQIAKAVTENLGGQGIFGVELFV
MLBr_00735|M.leprae_Br4923 ETVQRDGICVLVVAPALALADDLASAAQQLALRLAAELGVVGVFAVELFE
MUL_2628|M.ulcerans_Agy99 ETVQQDGICVAVIAPAPALSAQAGADAQQLALRLAAELGVVGVLAVELFE
. * :. ::.:* . ** *: .***:
Mb0395|M.bovis_AF2122/97 NGD-EVYFADVTVCPAGSAWVTVRSQRLSVFELQARATLGLAV-DTLMIS
Rv0389|M.tuberculosis_H37Rv NGD-EVYFADVTVCPAGSAWVTVRSQRLSVFELQARAILGLAV-DTLMIS
MMAR_0686|M.marinum_M NGD-EVYFADVQPFPRDTAWVTLRSQRLSVFELQARAILGFAV-DTLMVS
MAV_4775|M.avium_104 NDD-EVYFADVTAHPGDSAWVTVRSQRLSAFELQARTILGLPV-DTMMVS
MSMEG_0766|M.smegmatis_MC2_155 QGE-DVYFSDVRVRPHDSGLVTLRSQRLSEFELHARAILGLAC-DTIMIS
Mvan_0685|M.vanbaalenii_PYR-1 RGD-EVYFSDVRPRLQDSGLVTLRSQRLSQFELHARAVLGLPV-DTIMIS
TH_1415|M.thermoresistible__bu RDD-EVYFSDVRVRPQDTGLVTLRSQRLSHFELHARAILGLAV-DTIMIS
MAB_4245c|M.abscessus_ATCC_199 RGD-EVYFCDVSARPYDSGLVTVRSQRLSEYDMHARAVLGAPV-DTILVS
Mflv_2039|M.gilvum_PYR-GCK KGD-DVWFSEVSPRPHDTGMVTMVTQWQNEFELHARAILGLPV-DTTLKS
MLBr_00735|M.leprae_Br4923 TADGALLVNELAMRPHNSGHWTMDGARTSQFEQHLRAVLDYPLGETDAVA
MUL_2628|M.ulcerans_Agy99 TTDGALVVNELAMRPHNSGHWTMDGSRTSQFEQHLRAVLDYPLGDTEAIA
: : . :: .:. *: . :: : *: *. . :* :
Mb0395|M.bovis_AF2122/97 PGAARVINPD-HTAGRAAVGAAPPADALTGALG-VPESDVVIFGRG----
Rv0389|M.tuberculosis_H37Rv PGAARVINPD-HTAGRAAVGAAPPADALTGALG-VPESDVVIFGRG----
MMAR_0686|M.marinum_M PGAARLI-------GAATVGPVPGADALAAALA-VPESDVRVFGRPRAGS
MAV_4775|M.avium_104 PAAARVVD-------SADPGDR---AALSGALG-VPESDLRVCGRG----
MSMEG_0766|M.smegmatis_MC2_155 PGAAEVTYAG--AEAAPSV---DVTAVLGEALA-TSESDVRLFGR--AEE
Mvan_0685|M.vanbaalenii_PYR-1 PGAVEVSYPDGEGRAVPDR---EIRAVLADALA-VAESDVRLFPATAAGD
TH_1415|M.thermoresistible__bu PAAAEVHYGGSEAAWPGGTGGAELTAVLREALS-VPESDVRLFGG-PDDE
MAB_4245c|M.abscessus_ATCC_199 PAAAEVVYGD---------GDGPSPRQLDQALQ-TPESDLRVFGHTEAHR
Mflv_2039|M.gilvum_PYR-GCK PGASAVIYGG-------VDAEGVVFDGVDRALA-VPHTDIRLFGKPESFV
MLBr_00735|M.leprae_Br4923 PVTVMVNVLG--APQPPTLSVVTMDERLHHLFARMPDARVHLYDKVERPG
MUL_2628|M.ulcerans_Agy99 PVTVMTNVLG--AAAQPAMS---LDERLHHLFARMPDARVHLYGKDERPG
* : : : ..: : :
Mb0395|M.bovis_AF2122/97 ------LGVALAT-APEVAIARERAREVASRLNVPDSRE-----------
Rv0389|M.tuberculosis_H37Rv ------LGVALAT-APEVAIARERAREVASRLNVPDSRE-----------
MMAR_0686|M.marinum_M S----VLGVALAT-APDVAVARDRAREVVDRLNVRDSRG-----------
MAV_4775|M.avium_104 -------FRALAT-APEVAAARERAGQVAARLTAGAGGVGGAGG------
MSMEG_0766|M.smegmatis_MC2_155 SDDGRRLGVALAT-APDVIVARDRARRVGTALRRLW--------------
Mvan_0685|M.vanbaalenii_PYR-1 DDDVPWLSWSTAT-AQDPIVARDRARRVATAVRRLR--------------
TH_1415|M.thermoresistible__bu TDAPHRLGVALAT-APDATAARRQVRQVSTALRRLW--------------
MAB_4245c|M.abscessus_ATCC_199 R---RRVAVALAT-APNTALALNRAQQVARHLR-----------------
Mflv_2039|M.gilvum_PYR-GCK N---RRMGVALAF-ADDVDTARRNAAEAASRVTPRAV-------------
MLBr_00735|M.leprae_Br4923 RKVGHINFRGTDKDRKNPTKLRERAELAAHWLSHGQWTDGWDPHRAGDDV
MUL_2628|M.ulcerans_Agy99 RKVGHINFLGFDP--AAVAGLRERAELAAHWLSHGQWTDGWDPHG-----
. .. . :
Mb0395|M.bovis_AF2122/97 -----------------
Rv0389|M.tuberculosis_H37Rv -----------------
MMAR_0686|M.marinum_M -----------------
MAV_4775|M.avium_104 -----------------
MSMEG_0766|M.smegmatis_MC2_155 -----------------
Mvan_0685|M.vanbaalenii_PYR-1 -----------------
TH_1415|M.thermoresistible__bu -----------------
MAB_4245c|M.abscessus_ATCC_199 -----------------
Mflv_2039|M.gilvum_PYR-GCK -----------------
MLBr_00735|M.leprae_Br4923 VEISLACGGRNDAQRQR
MUL_2628|M.ulcerans_Agy99 -----------------