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VTDGLTEGHDEAIGKHQRPATEGANAPEGDKTTTIAVPPVGTPRRAEADVHVRPRVVLLGGGEQGRELTI ALQGLGAEVIAVDTDADAPAHRVADQALVVAMTDADELKVVFTRLRPDFVVPLTDAVSVAALDALADRAP SEGGSIGLVPSARCVRLAGDREALRKLAADQLGLPTAPFWFVGSLGELEAVAAHVGYPLLVKPVAGADVP RRSLVRGPDEVEAAWARAVAGGPAGAPPRVWAETQVEVEFLVTLIAVCSQGPQGPRIDFCAPIGHGGDGG DQESWQPQKVSVAALDAAKSIAARIVKALGGCGVFGVELMVNGDEVYFADVQPFPRDTAWVTLRSQRLSV FELQARAILGFAVDTLMVSPGAARLIGAATVGPVPGADALAAALAVPESDVRVFGRPRAGSSVLGVALAT APDVAVARDRAREVVDRLNVRDSRG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_0686 | purT | - | 100% (445) | formate-dependent phosphoribosylglycinamide formyltransferase PurT |
M. marinum M | MMAR_1260 | purK | 5e-14 | 26.41% (390) | phosphoribosylaminoimidazole carboxylase ATPase subunit PurK |
M. marinum M | MMAR_3848 | accA1 | 7e-06 | 29.19% (185) | acetyl-/propionyl-coenzyme A carboxylase alpha chain AccA1 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0395 | purT | 1e-142 | 62.64% (455) | phosphoribosylglycinamide formyltransferase 2 |
M. gilvum PYR-GCK | Mflv_0222 | - | 3e-88 | 50.77% (392) | ATP-dependent carboxylate-amine ligase domain-containing |
M. tuberculosis H37Rv | Rv0389 | purT | 1e-141 | 62.64% (455) | phosphoribosylglycinamide formyltransferase 2 |
M. leprae Br4923 | MLBr_00735 | purK | 8e-13 | 27.35% (340) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
M. abscessus ATCC 19977 | MAB_4245c | - | 8e-89 | 45.54% (437) | phosphoribosylglycinamide formyltransferase 2 |
M. avium 104 | MAV_4775 | purT | 1e-125 | 62.11% (417) | phosphoribosylglycinamide formyltransferase 2 |
M. smegmatis MC2 155 | MSMEG_0766 | purT | 1e-105 | 53.70% (419) | phosphoribosylglycinamide formyltransferase 2 |
M. thermoresistible (build 8) | TH_1415 | purT | 1e-107 | 52.24% (446) | PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT |
M. ulcerans Agy99 | MUL_2628 | purK | 1e-14 | 25.93% (428) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
M. vanbaalenii PYR-1 | Mvan_0685 | - | 9e-85 | 49.48% (388) | ATP-dependent carboxylate-amine ligase domain-containing |
CLUSTAL 2.0.9 multiple sequence alignment Mb0395|M.bovis_AF2122/97 -------------------------------------------------- Rv0389|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0686|M.marinum_M -------------------------------------------------- MAV_4775|M.avium_104 -------------------------------------------------- MSMEG_0766|M.smegmatis_MC2_155 ------------------------------------MSESIEGALTDDAA TH_1415|M.thermoresistible__bu -------------------------------------------------- Mflv_0222|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0685|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4245c|M.abscessus_ATCC_199 MNGIVVTQEGSPPSEQGTATSADIVEPVPAAAAPVTEEAVRATNGAKSGS MLBr_00735|M.leprae_Br4923 -------------------------------------------------- MUL_2628|M.ulcerans_Agy99 -------------------------------------------------- Mb0395|M.bovis_AF2122/97 ----------------------------MIDGWTEGQHEPTVRHERPAAP Rv0389|M.tuberculosis_H37Rv ----------------------------MIDGWTEEQHEPTVRHERPAAP MMAR_0686|M.marinum_M ----------------------------MTDGLTEGHDEAIGKHQRPATE MAV_4775|M.avium_104 ----------------------------MTDGRDDETTALAVPRPAPAEG MSMEG_0766|M.smegmatis_MC2_155 ADESAGAGPDDTDVTDDSVADTAPEDTAPDPDDTEPGDRAAADQETDTDP TH_1415|M.thermoresistible__bu -------------VTDPATDPTAEQATDPVAEAAGPGGEPKLQAGAPVDD Mflv_0222|M.gilvum_PYR-GCK --------------------------------------------MTEMET Mvan_0685|M.vanbaalenii_PYR-1 --------------------------------------------MSDTN- MAB_4245c|M.abscessus_ATCC_199 KTAKAATPVEAVGKTVEAGAPAPEAVADLAEGHTEDRTGQAVPQPPEAPA MLBr_00735|M.leprae_Br4923 ------------------------------------------MMAVPSRC MUL_2628|M.ulcerans_Agy99 ----------------------MIHNDLVLQPPNTPVMGHDTMMAVPS-- Mb0395|M.bovis_AF2122/97 ---------------------------QDVR-RVMLLGSAEPSRELAIAL Rv0389|M.tuberculosis_H37Rv ---------------------------QDVR-RVMLLGSAEPSRELAIAL MMAR_0686|M.marinum_M GANAPEGDKTTTIAVPPVGTPRRAEADVHVRPRVVLLGGGEQGRELTIAL MAV_4775|M.avium_104 GPAPADG----------------GPAPADGRPAVMLLGSGDISRELAIAL MSMEG_0766|M.smegmatis_MC2_155 EPQPVVGPD-----------------AADHRPTVMLLGGGALSRELALAF TH_1415|M.thermoresistible__bu EPAAQAEP------------------ARPARPTVMLLGAGELSRELVLAF Mflv_0222|M.gilvum_PYR-GCK --------------------------AHEGRTVVLLLGAGERTRELAPAF Mvan_0685|M.vanbaalenii_PYR-1 ------------------------------GETVLLLGAGERSSELALAF MAB_4245c|M.abscessus_ATCC_199 PADLPADEAEP---------------PAGNRTTVMLLGSGELAKELAISF MLBr_00735|M.leprae_Br4923 --------------------------SLGVAPLVAMVGGGQLARMTHQAA MUL_2628|M.ulcerans_Agy99 ----------------------------SRTPQVAMVGGGQLARMTHQAA * ::*.. : Mb0395|M.bovis_AF2122/97 QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVT Rv0389|M.tuberculosis_H37Rv QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVT MMAR_0686|M.marinum_M QGLGAEVIAVDTDADAPAHRVADQALVVAMTDADELKVVFTRLRPDFVVP MAV_4775|M.avium_104 GRLGARVIAVDAHPQAPAHAVADQALVLPLTDAGELSAAIHRLRPDVVVS MSMEG_0766|M.smegmatis_MC2_155 QNLGGVVVAVDRY-DAPAHGVADRTAVVDLNDADELSAVIAREKPQYVVA TH_1415|M.thermoresistible__bu QRLGAEVVAVDRYADAPAYPVADRSVVATMSDADALTAVIEREAPQYVVA Mflv_0222|M.gilvum_PYR-GCK EHLGAQVVTADAA-----------------ADAQTLTALIEQHAARYVVA Mvan_0685|M.vanbaalenii_PYR-1 RHLGADVVTVSDH-----------------GETQALTALIDERRPRYVVA MAB_4245c|M.abscessus_ATCC_199 QRLGAEVIVVDTGKGGPAQGVADRAVLAPIGESERLYELIEKERPRFVVP MLBr_00735|M.leprae_Br4923 IALGQTLRVLATAADEPAAQVTPDVVIGSHTDLEDLRRVALGADALTFDH MUL_2628|M.ulcerans_Agy99 IALGQNLRVLVNSADDPAAQVTPNVVIGSHTDLDDLRRIAAGADVVTFDH ** : . : * . Mb0395|M.bovis_AF2122/97 VTA------AVSVDALDAVEQ---ADGECTELVPNARAVRCTADREGLR- Rv0389|M.tuberculosis_H37Rv VTA------AVSVDALDAVEQ---ADGECTELVPNARAVRCTADREGLR- MMAR_0686|M.marinum_M LTD------AVSVAALDALADRAPSEGGSIGLVPSARCVRLAGDREALR- MAV_4775|M.avium_104 TTD------AVAVPALEALDG------TGAEPVPSARAVRLAADREGLR- MSMEG_0766|M.smegmatis_MC2_155 AESG-----VIAADALIAAAE-----RGDSEVLPTPRSIRLSQNREGLR- TH_1415|M.thermoresistible__bu EST------AVAVDALIAVAE-----RGSVEVFPTPRAIRLSYDREGLR- Mflv_0222|M.gilvum_PYR-GCK DLDTAEATNVATTGALHAIAD-----RDDVEVFPTLRSIRFALDGEALR- Mvan_0685|M.vanbaalenii_PYR-1 D-----AATVATD-ALIAVAE-----RDDVEVFPTPRATRLSLDGEGLR- MAB_4245c|M.abscessus_ATCC_199 LVE------AASREALDKLAEG-----EVTQVIPTAKAVRLAGDREGMR- MLBr_00735|M.leprae_Br4923 EH--------VPTELLDKLVA------EGINVAPSPQALVHAQDKLVMRR MUL_2628|M.ulcerans_Agy99 EH--------VPAELLDKLVA------EGVVLAPPPQALVHAQDKLVMRR . * * :. : : :* Mb0395|M.bovis_AF2122/97 RLAADQLGLP-TAPFWFVGSLGELQAVAVHAG----FPLLVSPVAGVAGQ Rv0389|M.tuberculosis_H37Rv RLAADQLGLP-TAPFWFVGSLGELQAVAVHAG----FPLLVSPVAGVAGQ MMAR_0686|M.marinum_M KLAADQLGLP-TAPFWFVGSLGELEAVAAHVG----YPLLVKPVAGADVP MAV_4775|M.avium_104 RLAADELGLP-TAPFWFAGSLGELEAVGAHAG----YPLLVKPVVGAVGP MSMEG_0766|M.smegmatis_MC2_155 RLASDELGLP-TVPFWFAGSVEELTAVAEHAG----YPLVVKPVTGSLRD TH_1415|M.thermoresistible__bu RLAADELGLP-TAPFWFAGSVEELTAVAQHAG----FPLVVRPVTGPAGS Mflv_0222|M.gilvum_PYR-GCK RLAADELGLP-TAPFWFAGTVEELTAIGQHAG----FPLVVKPVSGAPGE Mvan_0685|M.vanbaalenii_PYR-1 RLAADELGLP-TAPFWFAGSVEELTAIVAHAG----FPMVVKPVAAAPGE MAB_4245c|M.abscessus_ATCC_199 RMAAEELGLP-TPTYWFANSVEELRTVLETSG----FPAVVRPVAAAYGQ MLBr_00735|M.leprae_Br4923 RLAALGAAMPRFMALDSVDDLAEIDAFAQRLTGSKDAPMVVKAVRGGYDG MUL_2628|M.ulcerans_Agy99 RLQALDVPVPRYLGIHQLEELGELDAFARQL----DAPLVVKAVRGGYDG :: : :* : *: :. * :* .* . Mb0395|M.bovis_AF2122/97 GSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIEFLVTMIV Rv0389|M.tuberculosis_H37Rv GSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIEFLVTMIV MMAR_0686|M.marinum_M RRSLVRGPDEVEAAWARAVAG----GPAGAPPRVWAETQVEVEFLVTLIA MAV_4775|M.avium_104 RQSVVAGREDIAAAWHRAVDG----QPG---ARVLAETVVEVQFHVMLLA MSMEG_0766|M.smegmatis_MC2_155 GQSVLLRPDDIEPAWKRATTAGHF-----AHSRVLAESVVEVDFEVTMLT TH_1415|M.thermoresistible__bu GQSVLLREDDVEPAWHRAIAAGHF-----AQNRVMAETVVEIDYEVTMLT Mflv_0222|M.gilvum_PYR-GCK GESVLLRPEDVEPAWQRAVAAGAP-----TRRRVIAESVVEVDVEVTLLT Mvan_0685|M.vanbaalenii_PYR-1 GESVLLRPDDVEPAWRHATAAGN-------LKRVIAETVVEVDFEVTLLT MAB_4245c|M.abscessus_ATCC_199 GQSVVLRDGDVTPAWEQAIAANIG-----GGQRVMVETAVDIDYEITLLT MLBr_00735|M.leprae_Br4923 RGVQMVR--DSAHAREVASGYLVD------GMPVLVEERVELRRELSALV MUL_2628|M.ulcerans_Agy99 RGVQMAR--DLADARDIASGYLAG------GVPVLVEERVQLRRELSALV : : * * * .* *:: : :. Mb0395|M.bovis_AF2122/97 VCSQGPNGPL-IEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAAR Rv0389|M.tuberculosis_H37Rv VCSQGPNGPL-IEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAAR MMAR_0686|M.marinum_M VCSQGPQGPR-IDFCAPIGH-GGDGGDQESWQPQKVSVAALDAAKSIAAR MAV_4775|M.avium_104 VRSEGAAGPA-IEFCSPIGHRGAGGRVLESWQPQKMSPAAMDAAKSIAAR MSMEG_0766|M.smegmatis_MC2_155 IRTTGPTGPG-VQFCEPIGHRRSDNGVLESWQPQQMPPAALDSAKSIAAR TH_1415|M.thermoresistible__bu VRTTGPAGPT-IRFCEPIGHHHRNGEVLELWQPQQMSPVALDAAKSIAAR Mflv_0222|M.gilvum_PYR-GCK VRTAGPAGPT-VSFCEPIGHHQSPEGSLESWQPQQLSPVALDSAKSIAAR Mvan_0685|M.vanbaalenii_PYR-1 VRTTGAAGPT-VHFCEPIGHHQNDDDALESWQPQQLSPTALDSAKSIAAR MAB_4245c|M.abscessus_ATCC_199 VRTAGIGGATRLYFCEPIAHRQSGTDAMQMWQPQPLSQAALELARSIAAR MLBr_00735|M.leprae_Br4923 ARSPFGQGAA---WPVVETVQRDGICVLVVAPALALADDLASAAQQLALR MUL_2628|M.ulcerans_Agy99 ARSPFGQGAA---WPVVETVQQDGICVAVIAPAPALSAQAGADAQQLALR : *. : . :. *:.:* * Mb0395|M.bovis_AF2122/97 IVKALGGRGVFGVELMINGD-EVYFADVTVCPAGSAWVTVRSQRLSVFEL Rv0389|M.tuberculosis_H37Rv IVKALGGRGVFGVELMINGD-EVYFADVTVCPAGSAWVTVRSQRLSVFEL MMAR_0686|M.marinum_M IVKALGGCGVFGVELMVNGD-EVYFADVQPFPRDTAWVTLRSQRLSVFEL MAV_4775|M.avium_104 IVKALGGRGVFGVELMVNDD-EVYFADVTAHPGDSAWVTVRSQRLSAFEL MSMEG_0766|M.smegmatis_MC2_155 IVNSLGGRGVFGVELLVQGE-DVYFSDVRVRPHDSGLVTLRSQRLSEFEL TH_1415|M.thermoresistible__bu IVNSLGGRGVYGVELLVRDD-EVYFSDVRVRPQDTGLVTLRSQRLSHFEL Mflv_0222|M.gilvum_PYR-GCK IVNSLGGRGVFAVELLVRGD-EVYFSDVRPRLQDSGLVTLRSQRLSQFEL Mvan_0685|M.vanbaalenii_PYR-1 IVNSLGGRGVFAVELLVRGD-EVYFSDVRPRLQDSGLVTLRSQRLSQFEL MAB_4245c|M.abscessus_ATCC_199 AVNALGGHGVYGVELFVRGD-EVYFCDVSARPYDSGLVTVRSQRLSEYDM MLBr_00735|M.leprae_Br4923 LAAELGVVGVFAVELFETADGALLVNELAMRPHNSGHWTMDGARTSQFEQ MUL_2628|M.ulcerans_Agy99 LAAELGVVGVLAVELFETTDGALVVNELAMRPHNSGHWTMDGSRTSQFEQ . ** ** .***: : : . :: .:. *: . * * :: Mb0395|M.bovis_AF2122/97 QARATLGLAVDTLMISPGAARVINPDHTAGRAAV-GAAPPADALTGALGV Rv0389|M.tuberculosis_H37Rv QARAILGLAVDTLMISPGAARVINPDHTAGRAAV-GAAPPADALTGALGV MMAR_0686|M.marinum_M QARAILGFAVDTLMVSPGAARLI------GAATV-GPVPGADALAAALAV MAV_4775|M.avium_104 QARTILGLPVDTMMVSPAAARVVD------SADP-GDR---AALSGALGV MSMEG_0766|M.smegmatis_MC2_155 HARAILGLACDTIMISPGAAEVTYAGAEAAPS-----VDVTAVLGEALAT TH_1415|M.thermoresistible__bu HARAILGLAVDTIMISPAAAEVHYGGSEAAWPGGTGGAELTAVLREALSV Mflv_0222|M.gilvum_PYR-GCK HARAVLGLPVDTIMISPGAAEVTCS----------ADADARLVLGEALAV Mvan_0685|M.vanbaalenii_PYR-1 HARAVLGLPVDTIMISPGAVEVSYPDGEGRAV---PDREIRAVLADALAV MAB_4245c|M.abscessus_ATCC_199 HARAVLGAPVDTILVSPAAAEVVYGD---------GDGPSPRQLDQALQT MLBr_00735|M.leprae_Br4923 HLRAVLDYPLGETDAVAPVTVMVNVLGAPQPPTLSVVTMDERLHHLFARM MUL_2628|M.ulcerans_Agy99 HLRAVLDYPLGDTEAIAPVTVMTNVLGAAAQPAMS---LDERLHHLFARM : *: *. . . . .. : Mb0395|M.bovis_AF2122/97 PESDVVIFGRG----------LGVALAT-APEVAIARERAREVASRLNVP Rv0389|M.tuberculosis_H37Rv PESDVVIFGRG----------LGVALAT-APEVAIARERAREVASRLNVP MMAR_0686|M.marinum_M PESDVRVFGRPRA----GSSVLGVALAT-APDVAVARDRAREVVDRLNVR MAV_4775|M.avium_104 PESDLRVCGRG-----------FRALAT-APEVAAARERAGQVAARLTAG MSMEG_0766|M.smegmatis_MC2_155 SESDVRLFG-RAE-ESDDGRRLGVALAT-APDVIVARDRARRVGTALRRL TH_1415|M.thermoresistible__bu PESDVRLFG-GPDDETDAPHRLGVALAT-APDATAARRQVRQVSTALRRL Mflv_0222|M.gilvum_PYR-GCK AESDVRVLRSEPP--------VRVSLAT-APDPIVARDRARRVASALRRS Mvan_0685|M.vanbaalenii_PYR-1 AESDVRLFPATAAGDDDDVPWLSWSTAT-AQDPIVARDRARRVATAVRRL MAB_4245c|M.abscessus_ATCC_199 PESDLRVFGHTEAHR---RRRVAVALAT-APNTALALNRAQQVARHLR-- MLBr_00735|M.leprae_Br4923 PDARVHLYDKVERPGRKVGHINFRGTDKDRKNPTKLRERAELAAHWLSHG MUL_2628|M.ulcerans_Agy99 PDARVHLYGKDERPGRKVGHINFLGFDP--AAVAGLRERAELAAHWLSHG .:: : : . :. . : Mb0395|M.bovis_AF2122/97 DSRE---------------------------- Rv0389|M.tuberculosis_H37Rv DSRE---------------------------- MMAR_0686|M.marinum_M DSRG---------------------------- MAV_4775|M.avium_104 AGGVGGAGG----------------------- MSMEG_0766|M.smegmatis_MC2_155 W------------------------------- TH_1415|M.thermoresistible__bu W------------------------------- Mflv_0222|M.gilvum_PYR-GCK V------------------------------- Mvan_0685|M.vanbaalenii_PYR-1 R------------------------------- MAB_4245c|M.abscessus_ATCC_199 -------------------------------- MLBr_00735|M.leprae_Br4923 QWTDGWDPHRAGDDVVEISLACGGRNDAQRQR MUL_2628|M.ulcerans_Agy99 QWTDGWDPHG----------------------