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M. thermoresistible (build 8) TH_0889 (purK)

annotation: PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT PURK (AIR CARBOXYLASE) (AIRC)
coordinates: 1794700 - 1795866
length: 389

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0889purK-100% (389)PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT PURK (AIR CARBOXYLASE) (AIRC)
M. thermoresistible (build 8)TH_1415purT4e-1627.83% (327) PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT
M. thermoresistible (build 8)TH_3435-9e-0725.61% (285) PUTATIVE putative acetyl-/propionyl-coenzyme A carboxylase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3304cpurK1e-17175.39% (386) phosphoribosylaminoimidazole carboxylase ATPase subunit
M. gilvum PYR-GCKMflv_4747-1e-17677.95% (390) phosphoribosylaminoimidazole carboxylase ATPase subunit
M. tuberculosis H37RvRv3276cpurK1e-17175.39% (386) phosphoribosylaminoimidazole carboxylase ATPase subunit
M. leprae Br4923MLBr_00735purK1e-16874.31% (401) phosphoribosylaminoimidazole carboxylase ATPase subunit
M. abscessus ATCC 19977MAB_3620c-1e-16070.63% (395) phosphoribosylaminoimidazole carboxylase ATPase subunit
M. marinum MMMAR_1260purK1e-16975.00% (392) phosphoribosylaminoimidazole carboxylase ATPase subunit PurK
M. avium 104MAV_4245purK1e-17174.94% (391) phosphoribosylaminoimidazole carboxylase ATPase subunit
M. smegmatis MC2 155MSMEG_1819purK1e-17173.78% (389) phosphoribosylaminoimidazole carboxylase ATPase subunit
M. ulcerans Agy99MUL_2628purK1e-16975.00% (392) phosphoribosylaminoimidazole carboxylase ATPase subunit
M. vanbaalenii PYR-1Mvan_1713-1e-17376.61% (389) phosphoribosylaminoimidazole carboxylase ATPase subunit

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4747|M.gilvum_PYR-GCK          --MPHPAVTAGQRCGVGHDTMYAVSRRPSSP------PVVAMIGGGQLAR
Mvan_1713|M.vanbaalenii_PYR-1       --------------------MYAVSRTPASP------PVVAMIGGGQLAR
Mb3304c|M.bovis_AF2122/97           --------------------MMAVASSRTPAVTSFIAPLVAMVGGGQLAR
Rv3276c|M.tuberculosis_H37Rv        --------------------MMAVASSRTPAVTSFIAPLVAMVGGGQLAR
MMAR_1260|M.marinum_M               --------------------MMAVPSSRT--------PQVAMVGGGQLAR
MUL_2628|M.ulcerans_Agy99           MIHNDLVLQPPNTPVMGHDTMMAVPSSRT--------PQVAMVGGGQLAR
MAV_4245|M.avium_104                -----------------------------------------MVGGGQLAR
MLBr_00735|M.leprae_Br4923          --------------------MMAVPSRCSLG----VAPLVAMVGGGQLAR
TH_0889|M.thermoresistible__bu      ---------------------------------------VAMVGGGQLAR
MSMEG_1819|M.smegmatis_MC2_155      --------------------MPRASQTNSSA-----VPVVAMIGGGQLAR
MAB_3620c|M.abscessus_ATCC_199      --------------------MSAT-------------PVVTMIGGGQLAR
                                                                             *:*******

Mflv_4747|M.gilvum_PYR-GCK          MTAQAAIALGQTLRVLAVRSDESAAQVTPDVVLGSHTDLDALRRVADGAT
Mvan_1713|M.vanbaalenii_PYR-1       MTAQAAIALGQTLRVLAVRSDESAAQVTPDVVLGSHTDLDALRRVADGAT
Mb3304c|M.bovis_AF2122/97           MTHQAAIALGQNLRVLVTSADDPAAQVTPNVVIGSHTDLAALRRVAAGAD
Rv3276c|M.tuberculosis_H37Rv        MTHQAAIALGQNLRVLVTSADDPAAQVTPNVVIGSHTDLAALRRVAAGAD
MMAR_1260|M.marinum_M               MTHQAAIALGQNLRVLVNSADDPAAQVTPNVVIGSHTDLDDLRRIAAGAD
MUL_2628|M.ulcerans_Agy99           MTHQAAIALGQNLRVLVNSADDPAAQVTPNVVIGSHTDLDDLRRIAAGAD
MAV_4245|M.avium_104                MTHQAAIALGQSLRVLATAADESAALVASDVVIGSHTDLEDLRRVAAGAD
MLBr_00735|M.leprae_Br4923          MTHQAAIALGQTLRVLATAADEPAAQVTPDVVIGSHTDLEDLRRVALGAD
TH_0889|M.thermoresistible__bu      MTHQAAIALGQTLRVLAVDSDESAAQVTPDVVLGSHTDIDALRRAAAGAQ
MSMEG_1819|M.smegmatis_MC2_155      MTHQAAIALGQTLRVLAVDPNDPAAQVSPDIVLGSHTDYDALVKVAQGAT
MAB_3620c|M.abscessus_ATCC_199      MTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLRRAAKDAT
                                    ** **:*****.****.  .::.** *:.::*:****:   * : * .* 

Mflv_4747|M.gilvum_PYR-GCK          AFTFDHEHVPTEHLDVLIAEGVNVAPPPEALIHAQDKLLMRRRLSELGAP
Mvan_1713|M.vanbaalenii_PYR-1       AFTFDHEHVPPALLEQLVADGVNVLPPPSALVHAQDKLLMRERLSSLGVP
Mb3304c|M.bovis_AF2122/97           VLTFDHEHVPNELLEKLVADGVNVAPSPQALVHAQDKLVMRQRLAAAGVA
Rv3276c|M.tuberculosis_H37Rv        VLTFDHEHVPNELLEKLVADGVNVAPSPQALVHAQDKLVMRQRLAAAGVA
MMAR_1260|M.marinum_M               VVTFDHEHVPAELLDKLVAEGVVLAPPPQALVHAQDKLVMRRRLQALDVP
MUL_2628|M.ulcerans_Agy99           VVTFDHEHVPAELLDKLVAEGVVLAPPPQALVHAQDKLVMRRRLQALDVP
MAV_4245|M.avium_104                VLTFDHEHVPGELLDKLVAEGVNVAPPPQALVHAQDKLVMRRRLESLGVP
MLBr_00735|M.leprae_Br4923          ALTFDHEHVPTELLDKLVAEGINVAPSPQALVHAQDKLVMRRRLAALGAA
TH_0889|M.thermoresistible__bu      VLTFDHEHVPTELLEKLQAEGVNVAPPPQALIHAQDKLVMRRRLEALGAP
MSMEG_1819|M.smegmatis_MC2_155      VVTFDHEHVPTEHLDRLVADGVTVAPPPEALVHAQDKLVMRRRLADLGAP
MAB_3620c|M.abscessus_ATCC_199      VVTFDHEHVPTAFLETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAP
                                    ..********   *: * .:*: : *.*.**::**** :**.:*   ...

Mflv_4747|M.gilvum_PYR-GCK          VPRFSAVS---SVEDAVAFSEQV----GGPAVIKTVRGGYDGRGVVIASD
Mvan_1713|M.vanbaalenii_PYR-1       VPRYTAVG---SVDDAVAFCTEL----GGPVVIKTVRGGYDGRGVIMASS
Mb3304c|M.bovis_AF2122/97           VPRYAGIK---DPDEIDVFAARV----DAPIVVKAVRGGYDGRGVRMARD
Rv3276c|M.tuberculosis_H37Rv        VPRYAGIK---DPDEIDVFAARV----DAPIVVKAVRGGYDGRGVRMARD
MMAR_1260|M.marinum_M               VPRYLGIHQLEELGELDAFAREL----DAPLVVKAVRGGYDGRGVQMARD
MUL_2628|M.ulcerans_Agy99           VPRYLGIHQLEELGELDAFARQL----DAPLVVKAVRGGYDGRGVQMARD
MAV_4245|M.avium_104                VPRYAEIN---SLDELDAFARRV----GGPVVVKAVRGGYDGRGVRMARD
MLBr_00735|M.leprae_Br4923          MPRFMALDSVDDLAEIDAFAQRLTGSKDAPMVVKAVRGGYDGRGVQMVRD
TH_0889|M.thermoresistible__bu      VPRFAAVD---DVDDLDDFARRV----DAPLVLKTIRGGYDGRGVILTTD
MSMEG_1819|M.smegmatis_MC2_155      IPQFAEVT---AADEAQEFSREV----GGAAVIKTIRGGYDGRGVVLLDT
MAB_3620c|M.abscessus_ATCC_199      VPGFADIR---AVSDVERFAAET----GSHVVLKAVRGGYDGRGVWITDT
                                    :* :  :       :   *. .     ..  *:*::********* :   

Mflv_4747|M.gilvum_PYR-GCK          TDEVRSAVEGYLADGVPVMIEERVAMRRELAALVARSPFGQGAAWPVVET
Mvan_1713|M.vanbaalenii_PYR-1       VAEVRSVVSQYLDDGVPVLIEERVAMRRELAALVARSPFGQGAAWPVVET
Mb3304c|M.bovis_AF2122/97           VADARDFARECLADGVAVLVEERVDLRRELSALVARSPFGQGAAWPVVQT
Rv3276c|M.tuberculosis_H37Rv        VADARDFARECLADGVAVLVEERVDLRRELSALVARSPFGQGAAWPVVQT
MMAR_1260|M.marinum_M               LADARDIASGYLAGGVPVLVEERVQLRRELSALVARSPFGQGAAWPVVET
MUL_2628|M.ulcerans_Agy99           LADARDIASGYLAGGVPVLVEERVQLRRELSALVARSPFGQGAAWPVVET
MAV_4245|M.avium_104                PVHAREIAAAFLADGVPVLAEEQVSLRRELSALVARSPFGQGAAWPVVET
MLBr_00735|M.leprae_Br4923          SAHAREVASGYLVDGMPVLVEERVELRRELSALVARSPFGQGAAWPVVET
TH_0889|M.thermoresistible__bu      LPEAREAARRYLADGVPVLVEERVAMRRELTALVARSPFGQGAAWPVVET
MSMEG_1819|M.smegmatis_MC2_155      PEQAREVAAKYLTDGVPILIEERVAMRRELSALVARSAFGQGSAWPVVQT
MAB_3620c|M.abscessus_ATCC_199      LDEARTVAAEQLAAGVELLAEERVDMRRELSAMVARSPFGQGAAWPVVET
                                      ..*  .   *  *: :: **:* :****:*:****.****:*****:*

Mflv_4747|M.gilvum_PYR-GCK          VQRDGICVTVLAPAPDISDELGSAASELALHIASSLGVVGVLAVELFETV
Mvan_1713|M.vanbaalenii_PYR-1       VQRDGICVTVLAPAPGLSDELGSAASELALSVASSLGVVGVLAVELFETV
Mb3304c|M.bovis_AF2122/97           VQRDGTCVLVIAPAPALPDDLATAAQRLALQLADELGVVGVLAVELFETT
Rv3276c|M.tuberculosis_H37Rv        VQRDGTCVLVIAPAPALPDDLATAAQRLALQLADELGVVGVLAVELFETT
MMAR_1260|M.marinum_M               VQQDGICVAVIAPAPALSAQAGADAQQLALRLAAELGVVGVLAVELFETT
MUL_2628|M.ulcerans_Agy99           VQQDGICVAVIAPAPALSAQAGADAQQLALRLAAELGVVGVLAVELFETT
MAV_4245|M.avium_104                VQRDGICVQVIAPAPGLGEDLAADAQRLALRLAGELGVVGVLAVELFETT
MLBr_00735|M.leprae_Br4923          VQRDGICVLVVAPALALADDLASAAQQLALRLAAELGVVGVFAVELFETA
TH_0889|M.thermoresistible__bu      VQRDGICVEVLAPAPGLPDEVGAAAQELALRLAGELGVVGLLAVELFETA
MSMEG_1819|M.smegmatis_MC2_155      VQRDGICVEVIAPAPDLPDDLAASAQQLGLRLAAELGVIGVLAVELFETV
MAB_3620c|M.abscessus_ATCC_199      VQREGICAVVIAPAPQLPEELALQAEQLALRIANELGVTGCLAVELFETN
                                    **::* *. *:***  :  : .  *..*.* :* .*** * :******* 

Mflv_4747|M.gilvum_PYR-GCK          DGGLLVNELAMRPHNSGHWTMDGARTSQFEQHLRAVLDYPLGDTSALAP-
Mvan_1713|M.vanbaalenii_PYR-1       SGGLLVNELAMRPHNSGHWTMDGARTSQFEQHLRAVLDYPLGDTSALAP-
Mb3304c|M.bovis_AF2122/97           DGALLVNELAMRPHNSGHWTIDGARTSQFEQHLRAVLDYPLGDSDAVVPV
Rv3276c|M.tuberculosis_H37Rv        DGALLVNELAMRPHNSGHWTIDGARTSQFEQHLRAVLDYPLGDSDAVVPV
MMAR_1260|M.marinum_M               DGALVVNELAMRPHNSGHWTMDGSRTSQFEQHLRAVLDYPLGDTEAIAPV
MUL_2628|M.ulcerans_Agy99           DGALVVNELAMRPHNSGHWTMDGSRTSQFEQHLRAVLDYPLGDTEAIAPV
MAV_4245|M.avium_104                DGALLVNELAMRPHNSGHWTMDGSRTGQFEQHLRAVLDYPLGDTDALAPV
MLBr_00735|M.leprae_Br4923          DGALLVNELAMRPHNSGHWTMDGARTSQFEQHLRAVLDYPLGETDAVAPV
TH_0889|M.thermoresistible__bu      EGGLMVNELAMRPHNSGHWTMNGAVTSQFEQHLRAVLDYPLGDTSAIAPV
MSMEG_1819|M.smegmatis_MC2_155      DGRILVNELAMRPHNSGHWTMDGAVTSQFEQHLRAVLDYPLGETSARAEI
MAB_3620c|M.abscessus_ATCC_199      DGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYPLGSTEPLAPV
                                    .* ::**************:::*: *.***************.:.. .  

Mflv_4747|M.gilvum_PYR-GCK          TVMGNVLGAPETPAMS---MDERVHHLFARMPDAKVHLYGKEERPGRKIG
Mvan_1713|M.vanbaalenii_PYR-1       TAMGNVLGAPVTPAMS---MDERVHHLFARMPDAKVHLYGKEERPGRKIG
Mb3304c|M.bovis_AF2122/97           TVMANVLGAAQPPAMS---VDERLHHLFARMPDARVHLYGKAERPGRKVG
Rv3276c|M.tuberculosis_H37Rv        TVMANVLGAAQPPAMS---VDERLHHLFARMPDARVHLYGKAERPGRKVG
MMAR_1260|M.marinum_M               TVMTNVLGAAAQPAMS---LDERLHHLFARMPDARVHLYGKDERPGRKVG
MUL_2628|M.ulcerans_Agy99           TVMTNVLGAAAQPAMS---LDERLHHLFARMPDARVHLYGKDERPGRKVG
MAV_4245|M.avium_104                TVMANVLGARERPRMS---VDERLHHLFARMPDARVHLYGKGERPGRKVG
MLBr_00735|M.leprae_Br4923          TVMVNVLGAPQPPTLSVVTMDERLHHLFARMPDARVHLYDKVERPGRKVG
TH_0889|M.thermoresistible__bu      TVMANVLGAPQTPAMS---MDERLHHLFGRIPDARVHLYGKQERPGRKLG
MSMEG_1819|M.smegmatis_MC2_155      VVMSNVLGAPETPAMS---LDERIHHLFARMPDAKVHMYGKGERPGRKLG
MAB_3620c|M.abscessus_ATCC_199      TVMANVLGAPQTPAMS---LDERMHHLMGRIPEAKVHLYGKGERPGRKLG
                                    ..* *****   * :*   :***:***:.*:*:*:**:*.* ******:*

Mflv_4747|M.gilvum_PYR-GCK          HVNIVGGP------SEPVESLRERAERAAHWLSHAQWTDGWDSHA-----
Mvan_1713|M.vanbaalenii_PYR-1       HVNIVGG-------TESVESLRERAERAAHWLSHAEWTDGWDPHA-----
Mb3304c|M.bovis_AF2122/97           HINFLG------SD---VAQLCERAELAAHWLSHGRWTDGWDPHRASDDA
Rv3276c|M.tuberculosis_H37Rv        HINFLG------SD---VAQLCERAELAAHWLSHGRWTDGWDPHRASDDA
MMAR_1260|M.marinum_M               HINFLG------FDPAAVAGLRERAELAAHWLSHGQWTDGWDPHG-----
MUL_2628|M.ulcerans_Agy99           HINFLG------FDPAAVAGLRERAELAAHWLSHGQWTDGWDPHG-----
MAV_4245|M.avium_104                HINFLGDFPA--ADTAGLAALRRRAELAAHWLSHGQWTDGWDPHEQERHQ
MLBr_00735|M.leprae_Br4923          HINFRG--TD--KDRKNPTKLRERAELAAHWLSHGQWTDGWDPHRAGDDV
TH_0889|M.thermoresistible__bu      HVNVVG---------SDLAVVRERAGRAAHWLAHAQWTDGWDGHAD----
MSMEG_1819|M.smegmatis_MC2_155      HVNLVG------KPGEDVAAVRERANRASHWLSHAQWTDNWNEHGTDTE-
MAB_3620c|M.abscessus_ATCC_199      HVNIQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEGH------
                                    *:*. *              : .**  *:***:*. ***.*: *      

Mflv_4747|M.gilvum_PYR-GCK          ------------------
Mvan_1713|M.vanbaalenii_PYR-1       ------------------
Mb3304c|M.bovis_AF2122/97           VGVPPACGGRSDEEERRL
Rv3276c|M.tuberculosis_H37Rv        VGVPPACGGRSDEEERRL
MMAR_1260|M.marinum_M               ------------------
MUL_2628|M.ulcerans_Agy99           ------------------
MAV_4245|M.avium_104                ------------------
MLBr_00735|M.leprae_Br4923          VEISLACGGRNDAQRQR-
TH_0889|M.thermoresistible__bu      ------------------
MSMEG_1819|M.smegmatis_MC2_155      ------------------
MAB_3620c|M.abscessus_ATCC_199      ------------------