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M. thermoresistible (build 8) TH_0564 ()

annotation: CONSERVED HYPOTHETICAL PROTEIN
coordinates: 1207730 - 1209382
length: 551

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0564-100% (551)CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_4191-5e-1425.25% (590) PUTATIVE 3-ketosteroid-delta4
M. thermoresistible (build 8)TH_4085-8e-0823.22% (590) PUTATIVE fumarate reductase/succinate dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0808-1e-16978.96% (366) hypothetical protein Mb0808
M. gilvum PYR-GCKMflv_1621-0.081.22% (543) putative FAD-binding dehydrogenase
M. tuberculosis H37RvRv0785-0.078.57% (546) putative FAD-binding dehydrogenase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0695-0.079.60% (544) putative FAD-binding dehydrogenase
M. marinum MMMAR_4632-0.062.50% (552) hypothetical protein MMAR_4632
M. avium 104MAV_0732-0.081.32% (546) putative FAD-binding dehydrogenase
M. smegmatis MC2 155MSMEG_5835-0.082.36% (550) putative FAD-binding dehydrogenase
M. ulcerans Agy99MUL_0247-1e-12250.87% (460) hypothetical protein MUL_0247
M. vanbaalenii PYR-1Mvan_5132-0.081.58% (543) putative FAD-binding dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0808|M.bovis_AF2122/97            --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv         MALTCTDMSDAVAGSDAEGLTADAIVVGAGLAGLVAACELADRGLRVLIL
MAV_0732|M.avium_104                -----------MSDSSVAAFGADAIVVGAGLAGLVAACELVDRGLRVLVL
Mflv_1621|M.gilvum_PYR-GCK          -------------------MTADVIVVGAGLAGLVAACELAERGRSVLIV
Mvan_5132|M.vanbaalenii_PYR-1       ---------MADVSSAPHVRAADVIVVGAGLAGLVAACELADRGRSVLIV
TH_0564|M.thermoresistible__bu      ------------------MADADVIVVGAGLAGLVAACELVDRGRRVLIV
MSMEG_5835|M.smegmatis_MC2_155      ------------------MADADVIVVGAGLAGLVAACELVERGHSVIIV
MAB_0695|M.abscessus_ATCC_1997      ----------------MGDTSTDVIVVGAGLAGLVAACELVDRGKRVVIV
MMAR_4632|M.marinum_M               -------------------MDADVIVVGAGLAGLVATHELTRRGKKVAVV
MUL_0247|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

Mb0808|M.bovis_AF2122/97            --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv         DQENRANVGGQAFWSFGGLFLVNSPEQRRLGIRDSHELALQDWLGTAAFD
MAV_0732|M.avium_104                DQENSANLGGQAFWSFGGLFFVDSPEQRRLGIRDSHELALQDWLGTAAFD
Mflv_1621|M.gilvum_PYR-GCK          DQENSANVGGQAYWSFGGLFFVDSPEQRRLGIRDSHELALQDWLGTAGFD
Mvan_5132|M.vanbaalenii_PYR-1       DQENSANIGGQAYWSFGGLFFVDSPEQRRVGIRDSHELALQDWLGTAGFD
TH_0564|M.thermoresistible__bu      DQENAANLGGQAYWSFGGLFFVDSPEQRRLGIRDSYELAWQDWLGTAGFD
MSMEG_5835|M.smegmatis_MC2_155      DQENAANIGGQAFWSFGGLFFVNSPEQRRLGIRDSQELALQDWLGTAGFD
MAB_0695|M.abscessus_ATCC_1997      EQENAANLGGQAYWSFGGLFFVNSPEQRRLGIKDSHELALQDWLGTAGFD
MMAR_4632|M.marinum_M               DQENEKNLGGQAFWSFGGLFLVDSPEQRHLGIKDSLELAWNDWSGSAAFD
MUL_0247|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

Mb0808|M.bovis_AF2122/97            --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv         RP--EDYWPEQWAHAYVDFAAGEKRSWLRARGLKIFPLVGWAERGGYDAQ
MAV_0732|M.avium_104                RP--EDFWPRQWAHAYVDFAAGEKRSWLRARGLKLFPLVGWAERGGYDAQ
Mflv_1621|M.gilvum_PYR-GCK          RA--EDHWPRQWAHAYVDFAAGEKRSWLRDRGLQIFPLVGWAERGGYDAN
Mvan_5132|M.vanbaalenii_PYR-1       RP--EDHWPRQWAHAYVDFAAGEKRSWLRDRGLQIFPLVGWAERGGYGAN
TH_0564|M.thermoresistible__bu      RP--EDYWPRKWAEAYVNFATYEKRTWLRARGLQTFPVVGWAERGGYDAR
MSMEG_5835|M.smegmatis_MC2_155      RP--EDHWPREWAHAYVDFAAGEKRSWLRARGLQTFPLVGWAERGGYDAL
MAB_0695|M.abscessus_ATCC_1997      RP--EDHWPRQWAHAYVDFAAGEKRSWLRARGLQTFPVVAWAERGGKDAL
MMAR_4632|M.marinum_M               RPDDEDFWATKWARAYVEFAAGEKRSYLTDLGIRFMPTVGWAERGDLRAE
MUL_0247|M.ulcerans_Agy99           ----------------MEFAAGEKRSYLTDLGIRFMPTVGWAERGDLRAE
                                                                                      

Mb0808|M.bovis_AF2122/97            --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv         GHGNSVPRFHITWGTGPALVDIFVRQLRDRP---TVRFAHRHQVDKLIVE
MAV_0732|M.avium_104                GHGNSVPRFHITWGTGPALVEIFARRLRDRS---TVRFAHRHRVDELIVE
Mflv_1621|M.gilvum_PYR-GCK          GHGNSVPRFHITWGTGPALVDIFARRLIGNP---RVRFAHRHRVDELIVD
Mvan_5132|M.vanbaalenii_PYR-1       GHGNSVPRFHITWGTGPALVDIFARRLIGNP---RVRFAHRHRVDELIVD
TH_0564|M.thermoresistible__bu      GHGNSVPRFHITWGTGPAIVDIFARRLHAAAERSQVRFAFRHRVDELIVE
MSMEG_5835|M.smegmatis_MC2_155      GHGNSVPRFHITWGTGPALVEIFARRIRDSV---RVRFAHRHRVDELIVN
MAB_0695|M.abscessus_ATCC_1997      GPGNSVPRFHITWGTGPGLVEIFARRVLAAVDRGQVRIAYRHQVDELVVD
MMAR_4632|M.marinum_M               GHGNSVPRFHIAWGTGTGVVEPFVDSALQSAKDKLVTFYHRHRVDELVIT
MUL_0247|M.ulcerans_Agy99           GHGNSVPRFHIAWGTGTGVVEPFVDSALQSAKDKLVTFYHRHRVDELVIT
                                                                                      

Mb0808|M.bovis_AF2122/97            ---MTGVRGTVLEPSDEPRGAPSSRKSVGKFEFRASAVIVASGGIGGNHE
Rv0785|M.tuberculosis_H37Rv         GNAVTGVRGTVLEPSDEPRGAPSSRKSVGKFEFRASAVIVASGGIGGNHE
MAV_0732|M.avium_104                GGAVTGVRGSVLEPSAAPRGVASSRNTIAQFEFRADAVIVTSGGIGGNHE
Mflv_1621|M.gilvum_PYR-GCK          DGSVIGVRGAVLEPSDAVRGAPSSRNVVGDFEFRGQAVIVASGGIGGNHE
Mvan_5132|M.vanbaalenii_PYR-1       DGAVVGVRGAVLEPSSAVRGAESSRNVVGDFEFRAQAVIVASGGIGGNHE
TH_0564|M.thermoresistible__bu      DGVVVGVRGSVLEPSQAPRGFASSRKVVGDFEFRDAAVIVASGGIGGNHD
MSMEG_5835|M.smegmatis_MC2_155      AGLVAGVRGSILEPSNAPRGVASSRKVVGDFEFRASAVIVASGGIGGNLE
MAB_0695|M.abscessus_ATCC_1997      QGAVVGVRGTVLEPSTAARGIASSRIKLGEFEFRAQAVIVTSGGIGGNHD
MMAR_4632|M.marinum_M               DGVATGIKGTVLAPDDAERATSSNRDEVGEFELSAQAVIITTGGIGGNHD
MUL_0247|M.ulcerans_Agy99           DGVATGIKGTVLAPDDAERATPSNRDEVGEFELSAQAVIITTGGIGGNHD
                                         *::*::* *.   *.  *.*  :..**:   ***:::****** :

Mb0808|M.bovis_AF2122/97            LVRKNWPRRMGRIPKQLLSGVPAHVDGRMIGIAQKAGAAVINPDRMWHYT
Rv0785|M.tuberculosis_H37Rv         LVRKNWPRRMGRIPKQLLSGVPAHVDGRMIGIAQKAGAAVINPDRMWHYT
MAV_0732|M.avium_104                LVRKNWPKRMGRVPEQLLSGVPAHVDGRMIEITQRAGARVINPDRMWHYT
Mflv_1621|M.gilvum_PYR-GCK          LVRKYWPERMGRVPEQLLSGVPAHVDGRMLEISATAGASVINSDRMWHYT
Mvan_5132|M.vanbaalenii_PYR-1       LVRKCWPKRMGRVPEQLLSGVPAHVDGRMLEISATAGASVINSDRMWHYT
TH_0564|M.thermoresistible__bu      LVRQNWPPRMGRVPEQMLSGVPAYVDGRMMEIAEEAGANVINSDRMWHYT
MSMEG_5835|M.smegmatis_MC2_155      LVRKNWPARLGRVPDQLISGVPAHVDGRMIGIAESAGAHVINNDRMWHYT
MAB_0695|M.abscessus_ATCC_1997      LVRENWPERLGRVPSQLLTGVPAHVDGRMLGISVAAGAHLINRDRMWHYT
MMAR_4632|M.marinum_M               MVRRYWPDRMGTPPASMITGVPAYVDGRMLDIANDSGVRLVNRDRMWHYT
MUL_0247|M.ulcerans_Agy99           MVRRYWPDRMGTPPASMITGVPAYVDGRMLDIANDSEVRLVNRDRMWHYT
                                    :**. ** *:*  * .:::****:*****: *:  : . ::* *******

Mb0808|M.bovis_AF2122/97            EGITNYDPIWPRHGIRIIPGPSSLWLDAAGKRLPVPLFPGFDTLGTLEYI
Rv0785|M.tuberculosis_H37Rv         EGITNYDPIWPRHGIRIIPGPSSLWLDAAGKRLPVPLFPGFDTLGTLEYI
MAV_0732|M.avium_104                EGITNYEPIWPRHGIRIIPGPSSLWLDANGKRLPVPLYPGFDTLGTLEYI
Mflv_1621|M.gilvum_PYR-GCK          EGITNYDPIWPRHGIRILPGPSSLWLDATGKRLPVPLYPGFDTLGTLEHI
Mvan_5132|M.vanbaalenii_PYR-1       EGITNYDPIWPRHGIRILPGPSSLWLDAAGKRLPVPLYPGFDTLGTLEYI
TH_0564|M.thermoresistible__bu      EGITNYDPIWPLHGIRILPGPSSLWLDAHGKRLPAPLYPGFDTLGTLEYI
MSMEG_5835|M.smegmatis_MC2_155      EGITNYDPVWPNHGIRILPGPSSLWLDANGDRLPVPLYPGYDTLGTLEHI
MAB_0695|M.abscessus_ATCC_1997      EGITNHNPIWPGHGIRILPGPSSLWLDANGSRIPAPLFPGFDTLGTLEHI
MMAR_4632|M.marinum_M               EGVNNWDPIWPKHAIRIIPGPSSMWFDALGRRLPAPYLPGYDTLGTLRHL
MUL_0247|M.ulcerans_Agy99           EGVNNWDPIWPKHAIRIIPGPSSMWFDALGRRLPAP-LP--ARLRHLRHP
                                    **:.* :*:** *.***:*****:*:** * *:*.*  *    *  *.: 

Mb0808|M.bovis_AF2122/97            TKSGHD----YTWFVLN--------AKIIEKEFALSGQEQNPDLTGRRLG
Rv0785|M.tuberculosis_H37Rv         TKSGHD----YTWFVLN--------AKIIEKEFALSGQEQNPDLTGRRLG
MAV_0732|M.avium_104                TKSGFD----YTWFVLN--------AKIIEKEFALSGQEQNPDLTGQSVR
Mflv_1621|M.gilvum_PYR-GCK          AQTGQD----YTWFVLN--------SRIIDKEFGLSGQEQNPDLTGRSIR
Mvan_5132|M.vanbaalenii_PYR-1       AQTGQD----YTWFVLN--------SRIIAKEFGLSGQEQNPDLTDRSIR
TH_0564|M.thermoresistible__bu      TQTGQD----YTWFILN--------ARIIAKEFALSGQEQNPDLTGRSVR
MSMEG_5835|M.smegmatis_MC2_155      CRSGQD----YTWFILN--------ARIIAKEFALSGQEQNPDLTSRNVR
MAB_0695|M.abscessus_ATCC_1997      CRSGQD----YSWFILN--------ARIIAKEFALSGQEQNPDLTGKDVR
MMAR_4632|M.marinum_M               RTTPEIAKYDHSWFILN--------QKIIKKEFALSGSEQNPDITGKSRK
MUL_0247|M.ulcerans_Agy99           APPAHHRRDRQVRPLLVHLEPEDHQERVRPLGFRAEPRHHRQEPQSRSAR
                                      .           :*          ::    *  .  .:. :  .:   

Mb0808|M.bovis_AF2122/97            QLLRS--RAHAGPPGPVQAFIDRGVDFVHANSLRELVAAMNELPDVV-PL
Rv0785|M.tuberculosis_H37Rv         QLLRS--RAHAGPPGPVQAFIDRGVDCVHANSLRELVAAMNELPDVV-PL
MAV_0732|M.avium_104                ELLRN--RARSGPPGPVQAFVDRGVDFVSANSLRELVTAMNKLPDVA-PL
Mflv_1621|M.gilvum_PYR-GCK          AVLE---RSRKG-PAPVHAFVDKGVDFVTATSLRELVTRMNAIPGVV-PL
Mvan_5132|M.vanbaalenii_PYR-1       AVLE---RGRKG-PAPVHAFVDKGVDFVTATSLRELVTKMNAVPDVV-PL
TH_0564|M.thermoresistible__bu      DVLA---RIRPGAPEPVQAFVDRGADFVSANSLQGLVAAMNELPDVL-PL
MSMEG_5835|M.smegmatis_MC2_155      DLLS---RVKPGAPAPVQAFVDHGVDFVSATSLRDLVAGMNDLPDVV-PL
MAB_0695|M.abscessus_ATCC_1997      GVLR---RGKAGAPAPVQAFVDNGVDFVTATNLPDLVAKMNALPDVS-PL
MMAR_4632|M.marinum_M               AVLQERFLNKDATG-PVEAFKRHGADFVVANSLEELVEKMNGLTDEP-LL
MUL_0247|M.ulcerans_Agy99           TVFKQ---GRDRSGRGVQAPRRRLRGRQQPGRTRREDERPDRRTAAGSGR
                                     ::      :      *.*   .  .   .          :  .      

Mb0808|M.bovis_AF2122/97            DYETVAAAVTARDREVVNKYSKDGQITAIRAARRYRGDRFGRVVAPHRLT
Rv0785|M.tuberculosis_H37Rv         DYETVAAAVTARDREVVNKYSKDGQITAIRAARRYRGDRFGRVVAPHRLT
MAV_0732|M.avium_104                DYATVEAEVTARDREVANRFSKDGQITAIRAARGYLGDRLGRVVAPHRLT
Mflv_1621|M.gilvum_PYR-GCK          EFGVVEAEVTARDREVTNRFTKDGQVTAIRAARAYLPDRISRVVAPHRLT
Mvan_5132|M.vanbaalenii_PYR-1       DFDVVEAEVTARDREVTNRFTKDGQITAIRAARAYLPDRISRVVAPHRLT
TH_0564|M.thermoresistible__bu      DYATVAAEVAARDREVVNKFTKDTQVMAIRAARGYLGDRVSRVVAPHRLT
MSMEG_5835|M.smegmatis_MC2_155      DYAKVAAEVTARDREVANRFTKDGQITAIRAARNYLGDRFTRVVAPHRLT
MAB_0695|M.abscessus_ATCC_1997      DYATIAQQVTARDREVANPFGKDPQIAAIRAARAYLADRVARVVAPHRLT
MMAR_4632|M.marinum_M               DPAAIRRQIEARDLQVANPFCKDVQVQGIRNARRALGDRLGRVAAPHRIL
MUL_0247|M.ulcerans_Agy99           DPQAD----EARDLQVANPFCKDVQVQGIRNARRALGDRLGRVAAPHRIL
                                    :         *** :*.* : ** *: .** **    **. **.****: 

Mb0808|M.bovis_AF2122/97            DPKAGPLIAVKLHILTRKTLGGIETDLDARVLKADGTPLAGLYAAGEVAG
Rv0785|M.tuberculosis_H37Rv         DPKAGPLIAVKLHILTRKTLGGIETDLDARVLKADGTPLAGLYAAGEVAG
MAV_0732|M.avium_104                DPKAGPLIAVKLHILTRKTLGGIETDLASRVLGADGTPLTGLYAAGEAAG
Mflv_1621|M.gilvum_PYR-GCK          DPKAGPLIAVKLHILTRKSLGGLQTDLDSRVLRADGTVLPGLYAAGEAAG
Mvan_5132|M.vanbaalenii_PYR-1       DPKAGPLIAVKLHILTRKSLGGLQTDLDSRVLHDDGTVLPGLYAAGEAAG
TH_0564|M.thermoresistible__bu      DSKAGPLIAVKLHILTRKTLGGLETDLDSRVLRGDGEVFDGLYAAGEAAG
MSMEG_5835|M.smegmatis_MC2_155      DPKAGPLIAVKLHILTRKTLGGLETDLDSRVLKEDGTTFGGLYAAGEAAG
MAB_0695|M.abscessus_ATCC_1997      DPKAGPLIAVKLHILTRKTLGGLETDLDSRVLRADGSCFEGLYAAGEVAG
MMAR_4632|M.marinum_M               DPKAGPLIATKLHILTRKTLGGIQTDLSSRAIGSNGEPIAGLYAAGEVAG
MUL_0247|M.ulcerans_Agy99           DPKAGPLIATKLHILTRKTLGGIQTDLSSRAIGSNGEPIAGLYAAGEVAG
                                    *.*******.********:***::*** :*.:  :*  : *******.**

Mb0808|M.bovis_AF2122/97            FGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIR
Rv0785|M.tuberculosis_H37Rv         FGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIR
MAV_0732|M.avium_104                FGGGGVHGYRALEGTFLGGCIFSGRAAGRGVADDIT
Mflv_1621|M.gilvum_PYR-GCK          FGGGGVHGYRSLEGTFLGGCVFSGRAAGRHAAVAVG
Mvan_5132|M.vanbaalenii_PYR-1       FGGGGVHGYRSLEGTFLGGCVFSGRAAGRHAASAVG
TH_0564|M.thermoresistible__bu      FGGGGVHGYRSLEGTFLGGCIFSGRAAGRAAARDTA
MSMEG_5835|M.smegmatis_MC2_155      FGGGGVHGYRSLEGTFLGGCIFSGRAAGRGAAADIA
MAB_0695|M.abscessus_ATCC_1997      FGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIG
MMAR_4632|M.marinum_M               FGGGGVHGYNALEGTFLGGCIFSGRAAGRAAADAV-
MUL_0247|M.ulcerans_Agy99           FGGGGVHGYNALEGTFLGGSIFSGRAAGRAAADAV-
                                    *********.:********.:******** .*