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VEFAAGEKRSYLTDLGIRFMPTVGWAERGDLRAEGHGNSVPRFHIAWGTGTGVVEPFVDSALQSAKDKLV TFYHRHRVDELVITDGVATGIKGTVLAPDDAERATPSNRDEVGEFELSAQAVIITTGGIGGNHDMVRRYW PDRMGTPPASMITGVPAYVDGRMLDIANDSEVRLVNRDRMWHYTEGVNNWDPIWPKHAIRIIPGPSSMWF DALGRRLPAPLPARLRHLRHPAPPAHHRRDRQVRPLLVHLEPEDHQERVRPLGFRAEPRHHRQEPQSRSA RTVFKQGRDRSGRGVQAPRRRLRGRQQPGRTRREDERPDRRTAAGSGRDPQADEARDLQVANPFCKDVQV QGIRNARRALGDRLGRVAAPHRILDPKAGPLIATKLHILTRKTLGGIQTDLSSRAIGSNGEPIAGLYAAG EVAGFGGGGVHGYNALEGTFLGGSIFSGRAAGRAAADAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0247 | - | - | 100% (459) | hypothetical protein MUL_0247 |
| M. ulcerans Agy99 | MUL_3063 | - | 8e-06 | 44.78% (67) | flavoprotein |
| M. ulcerans Agy99 | MUL_1172 | sdhA | 5e-05 | 40.91% (66) | succinate dehydrogenase flavoprotein subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0808 | - | 3e-97 | 50.66% (381) | hypothetical protein Mb0808 |
| M. gilvum PYR-GCK | Mflv_1621 | - | 1e-124 | 51.29% (466) | putative FAD-binding dehydrogenase |
| M. tuberculosis H37Rv | Rv0785 | - | 1e-125 | 51.06% (470) | putative FAD-binding dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0695 | - | 1e-122 | 50.76% (463) | putative FAD-binding dehydrogenase |
| M. marinum M | MMAR_4632 | - | 0.0 | 77.12% (472) | hypothetical protein MMAR_4632 |
| M. avium 104 | MAV_0732 | - | 1e-76 | 57.47% (221) | putative FAD-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5835 | - | 1e-94 | 44.59% (471) | putative FAD-binding dehydrogenase |
| M. thermoresistible (build 8) | TH_0564 | - | 1e-122 | 50.87% (460) | CONSERVED HYPOTHETICAL PROTEIN |
| M. vanbaalenii PYR-1 | Mvan_5132 | - | 1e-121 | 49.47% (469) | putative FAD-binding dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1621|M.gilvum_PYR-GCK -------------------MTADVIVVGAGLAGLVAACELAERGRSVLIV
Mvan_5132|M.vanbaalenii_PYR-1 ---------MADVSSAPHVRAADVIVVGAGLAGLVAACELADRGRSVLIV
TH_0564|M.thermoresistible__bu ------------------MADADVIVVGAGLAGLVAACELVDRGRRVLIV
MSMEG_5835|M.smegmatis_MC2_155 ------------------MADADVIVVGAGLAGLVAACELVERGHSVIIV
Mb0808|M.bovis_AF2122/97 --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv MALTCTDMSDAVAGSDAEGLTADAIVVGAGLAGLVAACELADRGLRVLIL
MAV_0732|M.avium_104 -----------MSDSSVAAFGADAIVVGAGLAGLVAACELVDRGLRVLVL
MAB_0695|M.abscessus_ATCC_1997 ----------------MGDTSTDVIVVGAGLAGLVAACELVDRGKRVVIV
MUL_0247|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4632|M.marinum_M -------------------MDADVIVVGAGLAGLVATHELTRRGKKVAVV
Mflv_1621|M.gilvum_PYR-GCK DQENSANVGGQAYWSFGGLFFVDSPEQRRLGIRDSHELALQDWLGTAGFD
Mvan_5132|M.vanbaalenii_PYR-1 DQENSANIGGQAYWSFGGLFFVDSPEQRRVGIRDSHELALQDWLGTAGFD
TH_0564|M.thermoresistible__bu DQENAANLGGQAYWSFGGLFFVDSPEQRRLGIRDSYELAWQDWLGTAGFD
MSMEG_5835|M.smegmatis_MC2_155 DQENAANIGGQAFWSFGGLFFVNSPEQRRLGIRDSQELALQDWLGTAGFD
Mb0808|M.bovis_AF2122/97 --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv DQENRANVGGQAFWSFGGLFLVNSPEQRRLGIRDSHELALQDWLGTAAFD
MAV_0732|M.avium_104 DQENSANLGGQAFWSFGGLFFVDSPEQRRLGIRDSHELALQDWLGTAAFD
MAB_0695|M.abscessus_ATCC_1997 EQENAANLGGQAYWSFGGLFFVNSPEQRRLGIKDSHELALQDWLGTAGFD
MUL_0247|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4632|M.marinum_M DQENEKNLGGQAFWSFGGLFLVDSPEQRHLGIKDSLELAWNDWSGSAAFD
Mflv_1621|M.gilvum_PYR-GCK RA--EDHWPRQWAHAYVDFAAGEKRSWLRDRGLQIFPLVGWAERGGYDAN
Mvan_5132|M.vanbaalenii_PYR-1 RP--EDHWPRQWAHAYVDFAAGEKRSWLRDRGLQIFPLVGWAERGGYGAN
TH_0564|M.thermoresistible__bu RP--EDYWPRKWAEAYVNFATYEKRTWLRARGLQTFPVVGWAERGGYDAR
MSMEG_5835|M.smegmatis_MC2_155 RP--EDHWPREWAHAYVDFAAGEKRSWLRARGLQTFPLVGWAERGGYDAL
Mb0808|M.bovis_AF2122/97 --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv RP--EDYWPEQWAHAYVDFAAGEKRSWLRARGLKIFPLVGWAERGGYDAQ
MAV_0732|M.avium_104 RP--EDFWPRQWAHAYVDFAAGEKRSWLRARGLKLFPLVGWAERGGYDAQ
MAB_0695|M.abscessus_ATCC_1997 RP--EDHWPRQWAHAYVDFAAGEKRSWLRARGLQTFPVVAWAERGGKDAL
MUL_0247|M.ulcerans_Agy99 ----------------MEFAAGEKRSYLTDLGIRFMPTVGWAERGDLRAE
MMAR_4632|M.marinum_M RPDDEDFWATKWARAYVEFAAGEKRSYLTDLGIRFMPTVGWAERGDLRAE
Mflv_1621|M.gilvum_PYR-GCK GHGNSVPRFHITWGTGPALVDIFARRLIGNP---RVRFAHRHRVDELIVD
Mvan_5132|M.vanbaalenii_PYR-1 GHGNSVPRFHITWGTGPALVDIFARRLIGNP---RVRFAHRHRVDELIVD
TH_0564|M.thermoresistible__bu GHGNSVPRFHITWGTGPAIVDIFARRLHAAAERSQVRFAFRHRVDELIVE
MSMEG_5835|M.smegmatis_MC2_155 GHGNSVPRFHITWGTGPALVEIFARRIRDSV---RVRFAHRHRVDELIVN
Mb0808|M.bovis_AF2122/97 --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv GHGNSVPRFHITWGTGPALVDIFVRQLRDRP---TVRFAHRHQVDKLIVE
MAV_0732|M.avium_104 GHGNSVPRFHITWGTGPALVEIFARRLRDRS---TVRFAHRHRVDELIVE
MAB_0695|M.abscessus_ATCC_1997 GPGNSVPRFHITWGTGPGLVEIFARRVLAAVDRGQVRIAYRHQVDELVVD
MUL_0247|M.ulcerans_Agy99 GHGNSVPRFHIAWGTGTGVVEPFVDSALQSAKDKLVTFYHRHRVDELVIT
MMAR_4632|M.marinum_M GHGNSVPRFHIAWGTGTGVVEPFVDSALQSAKDKLVTFYHRHRVDELVIT
Mflv_1621|M.gilvum_PYR-GCK DGSVIGVRGAVLEPSDAVRGAPSSRNVVGDFEFRGQAVIVASGGIGGNHE
Mvan_5132|M.vanbaalenii_PYR-1 DGAVVGVRGAVLEPSSAVRGAESSRNVVGDFEFRAQAVIVASGGIGGNHE
TH_0564|M.thermoresistible__bu DGVVVGVRGSVLEPSQAPRGFASSRKVVGDFEFRDAAVIVASGGIGGNHD
MSMEG_5835|M.smegmatis_MC2_155 AGLVAGVRGSILEPSNAPRGVASSRKVVGDFEFRASAVIVASGGIGGNLE
Mb0808|M.bovis_AF2122/97 ---MTGVRGTVLEPSDEPRGAPSSRKSVGKFEFRASAVIVASGGIGGNHE
Rv0785|M.tuberculosis_H37Rv GNAVTGVRGTVLEPSDEPRGAPSSRKSVGKFEFRASAVIVASGGIGGNHE
MAV_0732|M.avium_104 GGAVTGVRGSVLEPSAAPRGVASSRNTIAQFEFRADAVIVTSGGIGGNHE
MAB_0695|M.abscessus_ATCC_1997 QGAVVGVRGTVLEPSTAARGIASSRIKLGEFEFRAQAVIVTSGGIGGNHD
MUL_0247|M.ulcerans_Agy99 DGVATGIKGTVLAPDDAERATPSNRDEVGEFELSAQAVIITTGGIGGNHD
MMAR_4632|M.marinum_M DGVATGIKGTVLAPDDAERATSSNRDEVGEFELSAQAVIITTGGIGGNHD
*::*::* *. *. *.* :..**: ***:::****** :
Mflv_1621|M.gilvum_PYR-GCK LVRKYWPERMGRVPEQLLSGVPAHVDGRMLEISATAGASVINSDRMWHYT
Mvan_5132|M.vanbaalenii_PYR-1 LVRKCWPKRMGRVPEQLLSGVPAHVDGRMLEISATAGASVINSDRMWHYT
TH_0564|M.thermoresistible__bu LVRQNWPPRMGRVPEQMLSGVPAYVDGRMMEIAEEAGANVINSDRMWHYT
MSMEG_5835|M.smegmatis_MC2_155 LVRKNWPARLGRVPDQLISGVPAHVDGRMIGIAESAGAHVINNDRMWHYT
Mb0808|M.bovis_AF2122/97 LVRKNWPRRMGRIPKQLLSGVPAHVDGRMIGIAQKAGAAVINPDRMWHYT
Rv0785|M.tuberculosis_H37Rv LVRKNWPRRMGRIPKQLLSGVPAHVDGRMIGIAQKAGAAVINPDRMWHYT
MAV_0732|M.avium_104 LVRKNWPKRMGRVPEQLLSGVPAHVDGRMIEITQRAGARVINPDRMWHYT
MAB_0695|M.abscessus_ATCC_1997 LVRENWPERLGRVPSQLLTGVPAHVDGRMLGISVAAGAHLINRDRMWHYT
MUL_0247|M.ulcerans_Agy99 MVRRYWPDRMGTPPASMITGVPAYVDGRMLDIANDSEVRLVNRDRMWHYT
MMAR_4632|M.marinum_M MVRRYWPDRMGTPPASMITGVPAYVDGRMLDIANDSGVRLVNRDRMWHYT
:**. ** *:* * .:::****:*****: *: : . ::* *******
Mflv_1621|M.gilvum_PYR-GCK EGITNYDPIWPRHGIRILPGPSSLWLDATGKRLPVPLYPGFDTLGTLEHI
Mvan_5132|M.vanbaalenii_PYR-1 EGITNYDPIWPRHGIRILPGPSSLWLDAAGKRLPVPLYPGFDTLGTLEYI
TH_0564|M.thermoresistible__bu EGITNYDPIWPLHGIRILPGPSSLWLDAHGKRLPAPLYPGFDTLGTLEYI
MSMEG_5835|M.smegmatis_MC2_155 EGITNYDPVWPNHGIRILPGPSSLWLDANGDRLPVPLYPGYDTLGTLEHI
Mb0808|M.bovis_AF2122/97 EGITNYDPIWPRHGIRIIPGPSSLWLDAAGKRLPVPLFPGFDTLGTLEYI
Rv0785|M.tuberculosis_H37Rv EGITNYDPIWPRHGIRIIPGPSSLWLDAAGKRLPVPLFPGFDTLGTLEYI
MAV_0732|M.avium_104 EGITNYEPIWPRHGIRIIPGPSSLWLDANGKRLPVPLYPGFDTLGTLEYI
MAB_0695|M.abscessus_ATCC_1997 EGITNHNPIWPGHGIRILPGPSSLWLDANGSRIPAPLFPGFDTLGTLEHI
MUL_0247|M.ulcerans_Agy99 EGVNNWDPIWPKHAIRIIPGPSSMWFDALGRRLPAP-LP--ARLRHLRHP
MMAR_4632|M.marinum_M EGVNNWDPIWPKHAIRIIPGPSSMWFDALGRRLPAPYLPGYDTLGTLRHL
**:.* :*:** *.***:*****:*:** * *:*.* * * *.:
Mflv_1621|M.gilvum_PYR-GCK AQTGQD----YTWFVLN--------SRIIDKEFGLSGQEQNPDLTGRSIR
Mvan_5132|M.vanbaalenii_PYR-1 AQTGQD----YTWFVLN--------SRIIAKEFGLSGQEQNPDLTDRSIR
TH_0564|M.thermoresistible__bu TQTGQD----YTWFILN--------ARIIAKEFALSGQEQNPDLTGRSVR
MSMEG_5835|M.smegmatis_MC2_155 CRSGQD----YTWFILN--------ARIIAKEFALSGQEQNPDLTSRNVR
Mb0808|M.bovis_AF2122/97 TKSGHD----YTWFVLN--------AKIIEKEFALSGQEQNPDLTGRRLG
Rv0785|M.tuberculosis_H37Rv TKSGHD----YTWFVLN--------AKIIEKEFALSGQEQNPDLTGRRLG
MAV_0732|M.avium_104 TKSGFD----YTWFVLN--------AKIIEKEFALSGQEQNPDLTGQSVR
MAB_0695|M.abscessus_ATCC_1997 CRSGQD----YSWFILN--------ARIIAKEFALSGQEQNPDLTGKDVR
MUL_0247|M.ulcerans_Agy99 APPAHHRRDRQVRPLLVHLEPEDHQERVRPLGFRAEPRHHRQEPQSRSAR
MMAR_4632|M.marinum_M RTTPEIAKYDHSWFILN--------QKIIKKEFALSGSEQNPDITGKSRK
. :* :: * . .:. : .:
Mflv_1621|M.gilvum_PYR-GCK AVLE---RSRKG-PAPVHAFVDKGVDFVTATSLRELVTRMNAIPGVV-PL
Mvan_5132|M.vanbaalenii_PYR-1 AVLE---RGRKG-PAPVHAFVDKGVDFVTATSLRELVTKMNAVPDVV-PL
TH_0564|M.thermoresistible__bu DVLA---RIRPGAPEPVQAFVDRGADFVSANSLQGLVAAMNELPDVL-PL
MSMEG_5835|M.smegmatis_MC2_155 DLLS---RVKPGAPAPVQAFVDHGVDFVSATSLRDLVAGMNDLPDVV-PL
Mb0808|M.bovis_AF2122/97 QLLRS--RAHAGPPGPVQAFIDRGVDFVHANSLRELVAAMNELPDVV-PL
Rv0785|M.tuberculosis_H37Rv QLLRS--RAHAGPPGPVQAFIDRGVDCVHANSLRELVAAMNELPDVV-PL
MAV_0732|M.avium_104 ELLRN--RARSGPPGPVQAFVDRGVDFVSANSLRELVTAMNKLPDVA-PL
MAB_0695|M.abscessus_ATCC_1997 GVLR---RGKAGAPAPVQAFVDNGVDFVTATNLPDLVAKMNALPDVS-PL
MUL_0247|M.ulcerans_Agy99 TVFKQ---GRDRSGRGVQAPRRRLRGRQQPGRTRREDERPDRRTAAGSGR
MMAR_4632|M.marinum_M AVLQERFLNKDATG-PVEAFKRHGADFVVANSLEELVEKMNGLTDEP-LL
:: : *.* . . . : .
Mflv_1621|M.gilvum_PYR-GCK EFGVVEAEVTARDREVTNRFTKDGQVTAIRAARAYLPDRISRVVAPHRLT
Mvan_5132|M.vanbaalenii_PYR-1 DFDVVEAEVTARDREVTNRFTKDGQITAIRAARAYLPDRISRVVAPHRLT
TH_0564|M.thermoresistible__bu DYATVAAEVAARDREVVNKFTKDTQVMAIRAARGYLGDRVSRVVAPHRLT
MSMEG_5835|M.smegmatis_MC2_155 DYAKVAAEVTARDREVANRFTKDGQITAIRAARNYLGDRFTRVVAPHRLT
Mb0808|M.bovis_AF2122/97 DYETVAAAVTARDREVVNKYSKDGQITAIRAARRYRGDRFGRVVAPHRLT
Rv0785|M.tuberculosis_H37Rv DYETVAAAVTARDREVVNKYSKDGQITAIRAARRYRGDRFGRVVAPHRLT
MAV_0732|M.avium_104 DYATVEAEVTARDREVANRFSKDGQITAIRAARGYLGDRLGRVVAPHRLT
MAB_0695|M.abscessus_ATCC_1997 DYATIAQQVTARDREVANPFGKDPQIAAIRAARAYLADRVARVVAPHRLT
MUL_0247|M.ulcerans_Agy99 DPQAD----EARDLQVANPFCKDVQVQGIRNARRALGDRLGRVAAPHRIL
MMAR_4632|M.marinum_M DPAAIRRQIEARDLQVANPFCKDVQVQGIRNARRALGDRLGRVAAPHRIL
: *** :*.* : ** *: .** ** **. **.****:
Mflv_1621|M.gilvum_PYR-GCK DPKAGPLIAVKLHILTRKSLGGLQTDLDSRVLRADGTVLPGLYAAGEAAG
Mvan_5132|M.vanbaalenii_PYR-1 DPKAGPLIAVKLHILTRKSLGGLQTDLDSRVLHDDGTVLPGLYAAGEAAG
TH_0564|M.thermoresistible__bu DSKAGPLIAVKLHILTRKTLGGLETDLDSRVLRGDGEVFDGLYAAGEAAG
MSMEG_5835|M.smegmatis_MC2_155 DPKAGPLIAVKLHILTRKTLGGLETDLDSRVLKEDGTTFGGLYAAGEAAG
Mb0808|M.bovis_AF2122/97 DPKAGPLIAVKLHILTRKTLGGIETDLDARVLKADGTPLAGLYAAGEVAG
Rv0785|M.tuberculosis_H37Rv DPKAGPLIAVKLHILTRKTLGGIETDLDARVLKADGTPLAGLYAAGEVAG
MAV_0732|M.avium_104 DPKAGPLIAVKLHILTRKTLGGIETDLASRVLGADGTPLTGLYAAGEAAG
MAB_0695|M.abscessus_ATCC_1997 DPKAGPLIAVKLHILTRKTLGGLETDLDSRVLRADGSCFEGLYAAGEVAG
MUL_0247|M.ulcerans_Agy99 DPKAGPLIATKLHILTRKTLGGIQTDLSSRAIGSNGEPIAGLYAAGEVAG
MMAR_4632|M.marinum_M DPKAGPLIATKLHILTRKTLGGIQTDLSSRAIGSNGEPIAGLYAAGEVAG
*.*******.********:***::*** :*.: :* : *******.**
Mflv_1621|M.gilvum_PYR-GCK FGGGGVHGYRSLEGTFLGGCVFSGRAAGRHAAVAVG
Mvan_5132|M.vanbaalenii_PYR-1 FGGGGVHGYRSLEGTFLGGCVFSGRAAGRHAASAVG
TH_0564|M.thermoresistible__bu FGGGGVHGYRSLEGTFLGGCIFSGRAAGRAAARDTA
MSMEG_5835|M.smegmatis_MC2_155 FGGGGVHGYRSLEGTFLGGCIFSGRAAGRGAAADIA
Mb0808|M.bovis_AF2122/97 FGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIR
Rv0785|M.tuberculosis_H37Rv FGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIR
MAV_0732|M.avium_104 FGGGGVHGYRALEGTFLGGCIFSGRAAGRGVADDIT
MAB_0695|M.abscessus_ATCC_1997 FGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIG
MUL_0247|M.ulcerans_Agy99 FGGGGVHGYNALEGTFLGGSIFSGRAAGRAAADAV-
MMAR_4632|M.marinum_M FGGGGVHGYNALEGTFLGGCIFSGRAAGRAAADAV-
*********.:********.:******** .*