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ADVSSAPHVRAADVIVVGAGLAGLVAACELADRGRSVLIVDQENSANIGGQAYWSFGGLFFVDSPEQRRV GIRDSHELALQDWLGTAGFDRPEDHWPRQWAHAYVDFAAGEKRSWLRDRGLQIFPLVGWAERGGYGANGH GNSVPRFHITWGTGPALVDIFARRLIGNPRVRFAHRHRVDELIVDDGAVVGVRGAVLEPSSAVRGAESSR NVVGDFEFRAQAVIVASGGIGGNHELVRKCWPKRMGRVPEQLLSGVPAHVDGRMLEISATAGASVINSDR MWHYTEGITNYDPIWPRHGIRILPGPSSLWLDAAGKRLPVPLYPGFDTLGTLEYIAQTGQDYTWFVLNSR IIAKEFGLSGQEQNPDLTDRSIRAVLERGRKGPAPVHAFVDKGVDFVTATSLRELVTKMNAVPDVVPLDF DVVEAEVTARDREVTNRFTKDGQITAIRAARAYLPDRISRVVAPHRLTDPKAGPLIAVKLHILTRKSLGG LQTDLDSRVLHDDGTVLPGLYAAGEAAGFGGGGVHGYRSLEGTFLGGCVFSGRAAGRHAASAVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5132 | - | - | 100% (555) | putative FAD-binding dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5210 | - | 9e-10 | 23.91% (552) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0284 | sdhA | 3e-09 | 21.81% (564) | succinate dehydrogenase flavoprotein subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0808 | - | 1e-166 | 77.66% (367) | hypothetical protein Mb0808 |
| M. gilvum PYR-GCK | Mflv_1621 | - | 0.0 | 95.21% (543) | putative FAD-binding dehydrogenase |
| M. tuberculosis H37Rv | Rv0785 | - | 0.0 | 79.60% (544) | putative FAD-binding dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0695 | - | 0.0 | 77.74% (548) | putative FAD-binding dehydrogenase |
| M. marinum M | MMAR_4632 | - | 0.0 | 60.29% (554) | hypothetical protein MMAR_4632 |
| M. avium 104 | MAV_0732 | - | 0.0 | 81.12% (556) | putative FAD-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5835 | - | 0.0 | 82.32% (543) | putative FAD-binding dehydrogenase |
| M. thermoresistible (build 8) | TH_0564 | - | 0.0 | 81.58% (543) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0247 | - | 1e-121 | 49.47% (469) | hypothetical protein MUL_0247 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0808|M.bovis_AF2122/97 --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv MALTCTDMSDAVAGSDAEGLTADAIVVGAGLAGLVAACELADRGLRVLIL
MAV_0732|M.avium_104 -----------MSDSSVAAFGADAIVVGAGLAGLVAACELVDRGLRVLVL
Mvan_5132|M.vanbaalenii_PYR-1 ---------MADVSSAPHVRAADVIVVGAGLAGLVAACELADRGRSVLIV
Mflv_1621|M.gilvum_PYR-GCK -------------------MTADVIVVGAGLAGLVAACELAERGRSVLIV
TH_0564|M.thermoresistible__bu ------------------MADADVIVVGAGLAGLVAACELVDRGRRVLIV
MSMEG_5835|M.smegmatis_MC2_155 ------------------MADADVIVVGAGLAGLVAACELVERGHSVIIV
MAB_0695|M.abscessus_ATCC_1997 ----------------MGDTSTDVIVVGAGLAGLVAACELVDRGKRVVIV
MMAR_4632|M.marinum_M -------------------MDADVIVVGAGLAGLVATHELTRRGKKVAVV
MUL_0247|M.ulcerans_Agy99 --------------------------------------------------
Mb0808|M.bovis_AF2122/97 --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv DQENRANVGGQAFWSFGGLFLVNSPEQRRLGIRDSHELALQDWLGTAAFD
MAV_0732|M.avium_104 DQENSANLGGQAFWSFGGLFFVDSPEQRRLGIRDSHELALQDWLGTAAFD
Mvan_5132|M.vanbaalenii_PYR-1 DQENSANIGGQAYWSFGGLFFVDSPEQRRVGIRDSHELALQDWLGTAGFD
Mflv_1621|M.gilvum_PYR-GCK DQENSANVGGQAYWSFGGLFFVDSPEQRRLGIRDSHELALQDWLGTAGFD
TH_0564|M.thermoresistible__bu DQENAANLGGQAYWSFGGLFFVDSPEQRRLGIRDSYELAWQDWLGTAGFD
MSMEG_5835|M.smegmatis_MC2_155 DQENAANIGGQAFWSFGGLFFVNSPEQRRLGIRDSQELALQDWLGTAGFD
MAB_0695|M.abscessus_ATCC_1997 EQENAANLGGQAYWSFGGLFFVNSPEQRRLGIKDSHELALQDWLGTAGFD
MMAR_4632|M.marinum_M DQENEKNLGGQAFWSFGGLFLVDSPEQRHLGIKDSLELAWNDWSGSAAFD
MUL_0247|M.ulcerans_Agy99 --------------------------------------------------
Mb0808|M.bovis_AF2122/97 --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv RP--EDYWPEQWAHAYVDFAAGEKRSWLRARGLKIFPLVGWAERGGYDAQ
MAV_0732|M.avium_104 RP--EDFWPRQWAHAYVDFAAGEKRSWLRARGLKLFPLVGWAERGGYDAQ
Mvan_5132|M.vanbaalenii_PYR-1 RP--EDHWPRQWAHAYVDFAAGEKRSWLRDRGLQIFPLVGWAERGGYGAN
Mflv_1621|M.gilvum_PYR-GCK RA--EDHWPRQWAHAYVDFAAGEKRSWLRDRGLQIFPLVGWAERGGYDAN
TH_0564|M.thermoresistible__bu RP--EDYWPRKWAEAYVNFATYEKRTWLRARGLQTFPVVGWAERGGYDAR
MSMEG_5835|M.smegmatis_MC2_155 RP--EDHWPREWAHAYVDFAAGEKRSWLRARGLQTFPLVGWAERGGYDAL
MAB_0695|M.abscessus_ATCC_1997 RP--EDHWPRQWAHAYVDFAAGEKRSWLRARGLQTFPVVAWAERGGKDAL
MMAR_4632|M.marinum_M RPDDEDFWATKWARAYVEFAAGEKRSYLTDLGIRFMPTVGWAERGDLRAE
MUL_0247|M.ulcerans_Agy99 ----------------MEFAAGEKRSYLTDLGIRFMPTVGWAERGDLRAE
Mb0808|M.bovis_AF2122/97 --------------------------------------------------
Rv0785|M.tuberculosis_H37Rv GHGNSVPRFHITWGTGPALVDIFVRQLRDRP---TVRFAHRHQVDKLIVE
MAV_0732|M.avium_104 GHGNSVPRFHITWGTGPALVEIFARRLRDRS---TVRFAHRHRVDELIVE
Mvan_5132|M.vanbaalenii_PYR-1 GHGNSVPRFHITWGTGPALVDIFARRLIGNP---RVRFAHRHRVDELIVD
Mflv_1621|M.gilvum_PYR-GCK GHGNSVPRFHITWGTGPALVDIFARRLIGNP---RVRFAHRHRVDELIVD
TH_0564|M.thermoresistible__bu GHGNSVPRFHITWGTGPAIVDIFARRLHAAAERSQVRFAFRHRVDELIVE
MSMEG_5835|M.smegmatis_MC2_155 GHGNSVPRFHITWGTGPALVEIFARRIRDSV---RVRFAHRHRVDELIVN
MAB_0695|M.abscessus_ATCC_1997 GPGNSVPRFHITWGTGPGLVEIFARRVLAAVDRGQVRIAYRHQVDELVVD
MMAR_4632|M.marinum_M GHGNSVPRFHIAWGTGTGVVEPFVDSALQSAKDKLVTFYHRHRVDELVIT
MUL_0247|M.ulcerans_Agy99 GHGNSVPRFHIAWGTGTGVVEPFVDSALQSAKDKLVTFYHRHRVDELVIT
Mb0808|M.bovis_AF2122/97 ---MTGVRGTVLEPSDEPRGAPSSRKSVGKFEFRASAVIVASGGIGGNHE
Rv0785|M.tuberculosis_H37Rv GNAVTGVRGTVLEPSDEPRGAPSSRKSVGKFEFRASAVIVASGGIGGNHE
MAV_0732|M.avium_104 GGAVTGVRGSVLEPSAAPRGVASSRNTIAQFEFRADAVIVTSGGIGGNHE
Mvan_5132|M.vanbaalenii_PYR-1 DGAVVGVRGAVLEPSSAVRGAESSRNVVGDFEFRAQAVIVASGGIGGNHE
Mflv_1621|M.gilvum_PYR-GCK DGSVIGVRGAVLEPSDAVRGAPSSRNVVGDFEFRGQAVIVASGGIGGNHE
TH_0564|M.thermoresistible__bu DGVVVGVRGSVLEPSQAPRGFASSRKVVGDFEFRDAAVIVASGGIGGNHD
MSMEG_5835|M.smegmatis_MC2_155 AGLVAGVRGSILEPSNAPRGVASSRKVVGDFEFRASAVIVASGGIGGNLE
MAB_0695|M.abscessus_ATCC_1997 QGAVVGVRGTVLEPSTAARGIASSRIKLGEFEFRAQAVIVTSGGIGGNHD
MMAR_4632|M.marinum_M DGVATGIKGTVLAPDDAERATSSNRDEVGEFELSAQAVIITTGGIGGNHD
MUL_0247|M.ulcerans_Agy99 DGVATGIKGTVLAPDDAERATPSNRDEVGEFELSAQAVIITTGGIGGNHD
*::*::* *. *. *.* :..**: ***:::****** :
Mb0808|M.bovis_AF2122/97 LVRKNWPRRMGRIPKQLLSGVPAHVDGRMIGIAQKAGAAVINPDRMWHYT
Rv0785|M.tuberculosis_H37Rv LVRKNWPRRMGRIPKQLLSGVPAHVDGRMIGIAQKAGAAVINPDRMWHYT
MAV_0732|M.avium_104 LVRKNWPKRMGRVPEQLLSGVPAHVDGRMIEITQRAGARVINPDRMWHYT
Mvan_5132|M.vanbaalenii_PYR-1 LVRKCWPKRMGRVPEQLLSGVPAHVDGRMLEISATAGASVINSDRMWHYT
Mflv_1621|M.gilvum_PYR-GCK LVRKYWPERMGRVPEQLLSGVPAHVDGRMLEISATAGASVINSDRMWHYT
TH_0564|M.thermoresistible__bu LVRQNWPPRMGRVPEQMLSGVPAYVDGRMMEIAEEAGANVINSDRMWHYT
MSMEG_5835|M.smegmatis_MC2_155 LVRKNWPARLGRVPDQLISGVPAHVDGRMIGIAESAGAHVINNDRMWHYT
MAB_0695|M.abscessus_ATCC_1997 LVRENWPERLGRVPSQLLTGVPAHVDGRMLGISVAAGAHLINRDRMWHYT
MMAR_4632|M.marinum_M MVRRYWPDRMGTPPASMITGVPAYVDGRMLDIANDSGVRLVNRDRMWHYT
MUL_0247|M.ulcerans_Agy99 MVRRYWPDRMGTPPASMITGVPAYVDGRMLDIANDSEVRLVNRDRMWHYT
:**. ** *:* * .:::****:*****: *: : . ::* *******
Mb0808|M.bovis_AF2122/97 EGITNYDPIWPRHGIRIIPGPSSLWLDAAGKRLPVPLFPGFDTLGTLEYI
Rv0785|M.tuberculosis_H37Rv EGITNYDPIWPRHGIRIIPGPSSLWLDAAGKRLPVPLFPGFDTLGTLEYI
MAV_0732|M.avium_104 EGITNYEPIWPRHGIRIIPGPSSLWLDANGKRLPVPLYPGFDTLGTLEYI
Mvan_5132|M.vanbaalenii_PYR-1 EGITNYDPIWPRHGIRILPGPSSLWLDAAGKRLPVPLYPGFDTLGTLEYI
Mflv_1621|M.gilvum_PYR-GCK EGITNYDPIWPRHGIRILPGPSSLWLDATGKRLPVPLYPGFDTLGTLEHI
TH_0564|M.thermoresistible__bu EGITNYDPIWPLHGIRILPGPSSLWLDAHGKRLPAPLYPGFDTLGTLEYI
MSMEG_5835|M.smegmatis_MC2_155 EGITNYDPVWPNHGIRILPGPSSLWLDANGDRLPVPLYPGYDTLGTLEHI
MAB_0695|M.abscessus_ATCC_1997 EGITNHNPIWPGHGIRILPGPSSLWLDANGSRIPAPLFPGFDTLGTLEHI
MMAR_4632|M.marinum_M EGVNNWDPIWPKHAIRIIPGPSSMWFDALGRRLPAPYLPGYDTLGTLRHL
MUL_0247|M.ulcerans_Agy99 EGVNNWDPIWPKHAIRIIPGPSSMWFDALGRRLPAP-LP--ARLRHLRHP
**:.* :*:** *.***:*****:*:** * *:*.* * * *.:
Mb0808|M.bovis_AF2122/97 TKSGHD----YTWFVLN--------AKIIEKEFALSGQEQNPDLTGRRLG
Rv0785|M.tuberculosis_H37Rv TKSGHD----YTWFVLN--------AKIIEKEFALSGQEQNPDLTGRRLG
MAV_0732|M.avium_104 TKSGFD----YTWFVLN--------AKIIEKEFALSGQEQNPDLTGQSVR
Mvan_5132|M.vanbaalenii_PYR-1 AQTGQD----YTWFVLN--------SRIIAKEFGLSGQEQNPDLTDRSIR
Mflv_1621|M.gilvum_PYR-GCK AQTGQD----YTWFVLN--------SRIIDKEFGLSGQEQNPDLTGRSIR
TH_0564|M.thermoresistible__bu TQTGQD----YTWFILN--------ARIIAKEFALSGQEQNPDLTGRSVR
MSMEG_5835|M.smegmatis_MC2_155 CRSGQD----YTWFILN--------ARIIAKEFALSGQEQNPDLTSRNVR
MAB_0695|M.abscessus_ATCC_1997 CRSGQD----YSWFILN--------ARIIAKEFALSGQEQNPDLTGKDVR
MMAR_4632|M.marinum_M RTTPEIAKYDHSWFILN--------QKIIKKEFALSGSEQNPDITGKSRK
MUL_0247|M.ulcerans_Agy99 APPAHHRRDRQVRPLLVHLEPEDHQERVRPLGFRAEPRHHRQEPQSRSAR
. :* :: * . .:. : .:
Mb0808|M.bovis_AF2122/97 QLLRS--RAHAGPPGPVQAFIDRGVDFVHANSLRELVAAMNELPDVV-PL
Rv0785|M.tuberculosis_H37Rv QLLRS--RAHAGPPGPVQAFIDRGVDCVHANSLRELVAAMNELPDVV-PL
MAV_0732|M.avium_104 ELLRN--RARSGPPGPVQAFVDRGVDFVSANSLRELVTAMNKLPDVA-PL
Mvan_5132|M.vanbaalenii_PYR-1 AVLE---RGRKG-PAPVHAFVDKGVDFVTATSLRELVTKMNAVPDVV-PL
Mflv_1621|M.gilvum_PYR-GCK AVLE---RSRKG-PAPVHAFVDKGVDFVTATSLRELVTRMNAIPGVV-PL
TH_0564|M.thermoresistible__bu DVLA---RIRPGAPEPVQAFVDRGADFVSANSLQGLVAAMNELPDVL-PL
MSMEG_5835|M.smegmatis_MC2_155 DLLS---RVKPGAPAPVQAFVDHGVDFVSATSLRDLVAGMNDLPDVV-PL
MAB_0695|M.abscessus_ATCC_1997 GVLR---RGKAGAPAPVQAFVDNGVDFVTATNLPDLVAKMNALPDVS-PL
MMAR_4632|M.marinum_M AVLQERFLNKDATG-PVEAFKRHGADFVVANSLEELVEKMNGLTDEP-LL
MUL_0247|M.ulcerans_Agy99 TVFKQ---GRDRSGRGVQAPRRRLRGRQQPGRTRREDERPDRRTAAGSGR
:: : *.* . . . : .
Mb0808|M.bovis_AF2122/97 DYETVAAAVTARDREVVNKYSKDGQITAIRAARRYRGDRFGRVVAPHRLT
Rv0785|M.tuberculosis_H37Rv DYETVAAAVTARDREVVNKYSKDGQITAIRAARRYRGDRFGRVVAPHRLT
MAV_0732|M.avium_104 DYATVEAEVTARDREVANRFSKDGQITAIRAARGYLGDRLGRVVAPHRLT
Mvan_5132|M.vanbaalenii_PYR-1 DFDVVEAEVTARDREVTNRFTKDGQITAIRAARAYLPDRISRVVAPHRLT
Mflv_1621|M.gilvum_PYR-GCK EFGVVEAEVTARDREVTNRFTKDGQVTAIRAARAYLPDRISRVVAPHRLT
TH_0564|M.thermoresistible__bu DYATVAAEVAARDREVVNKFTKDTQVMAIRAARGYLGDRVSRVVAPHRLT
MSMEG_5835|M.smegmatis_MC2_155 DYAKVAAEVTARDREVANRFTKDGQITAIRAARNYLGDRFTRVVAPHRLT
MAB_0695|M.abscessus_ATCC_1997 DYATIAQQVTARDREVANPFGKDPQIAAIRAARAYLADRVARVVAPHRLT
MMAR_4632|M.marinum_M DPAAIRRQIEARDLQVANPFCKDVQVQGIRNARRALGDRLGRVAAPHRIL
MUL_0247|M.ulcerans_Agy99 DPQAD----EARDLQVANPFCKDVQVQGIRNARRALGDRLGRVAAPHRIL
: *** :*.* : ** *: .** ** **. **.****:
Mb0808|M.bovis_AF2122/97 DPKAGPLIAVKLHILTRKTLGGIETDLDARVLKADGTPLAGLYAAGEVAG
Rv0785|M.tuberculosis_H37Rv DPKAGPLIAVKLHILTRKTLGGIETDLDARVLKADGTPLAGLYAAGEVAG
MAV_0732|M.avium_104 DPKAGPLIAVKLHILTRKTLGGIETDLASRVLGADGTPLTGLYAAGEAAG
Mvan_5132|M.vanbaalenii_PYR-1 DPKAGPLIAVKLHILTRKSLGGLQTDLDSRVLHDDGTVLPGLYAAGEAAG
Mflv_1621|M.gilvum_PYR-GCK DPKAGPLIAVKLHILTRKSLGGLQTDLDSRVLRADGTVLPGLYAAGEAAG
TH_0564|M.thermoresistible__bu DSKAGPLIAVKLHILTRKTLGGLETDLDSRVLRGDGEVFDGLYAAGEAAG
MSMEG_5835|M.smegmatis_MC2_155 DPKAGPLIAVKLHILTRKTLGGLETDLDSRVLKEDGTTFGGLYAAGEAAG
MAB_0695|M.abscessus_ATCC_1997 DPKAGPLIAVKLHILTRKTLGGLETDLDSRVLRADGSCFEGLYAAGEVAG
MMAR_4632|M.marinum_M DPKAGPLIATKLHILTRKTLGGIQTDLSSRAIGSNGEPIAGLYAAGEVAG
MUL_0247|M.ulcerans_Agy99 DPKAGPLIATKLHILTRKTLGGIQTDLSSRAIGSNGEPIAGLYAAGEVAG
*.*******.********:***::*** :*.: :* : *******.**
Mb0808|M.bovis_AF2122/97 FGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIR
Rv0785|M.tuberculosis_H37Rv FGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIR
MAV_0732|M.avium_104 FGGGGVHGYRALEGTFLGGCIFSGRAAGRGVADDIT
Mvan_5132|M.vanbaalenii_PYR-1 FGGGGVHGYRSLEGTFLGGCVFSGRAAGRHAASAVG
Mflv_1621|M.gilvum_PYR-GCK FGGGGVHGYRSLEGTFLGGCVFSGRAAGRHAAVAVG
TH_0564|M.thermoresistible__bu FGGGGVHGYRSLEGTFLGGCIFSGRAAGRAAARDTA
MSMEG_5835|M.smegmatis_MC2_155 FGGGGVHGYRSLEGTFLGGCIFSGRAAGRGAAADIA
MAB_0695|M.abscessus_ATCC_1997 FGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIG
MMAR_4632|M.marinum_M FGGGGVHGYNALEGTFLGGCIFSGRAAGRAAADAV-
MUL_0247|M.ulcerans_Agy99 FGGGGVHGYNALEGTFLGGSIFSGRAAGRAAADAV-
*********.:********.:******** .*