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RIGPVELSAVKDWDPAPGVLVSWHPTPASCAKALAAPVSAVPPSYVQARQIRSFSEQAARGLDHSRLLIA SVEVFGHCDLRAMTYVINAHLRRHDTYRSWFELRDTDHIVRHSIADPADIEFVPTTHGEMTSADLRQHIV ATPDSLHWDCFSFGVIQRADSFTFYASIDHLHADGQFVGVGLMEFQSMYTALIMGEPPIGLSEAGSYVDF CVRQHEYTSALTVDSPEVRAWIDFAEINNGTFPEFPLPLGDPSVRCGGDLLSMMLMDEQQTQRFESACMA ANARFIGGMLACIAIAIHELTGADTYFGITPKDIRTPADLMTQGWFTGQIPVTVPVAGLSFNEIARIAQT SFDTGADLAKVPFERVVELSPSLRRPQPLFSLVNFFDAQVGPLSAVTKLFEGLNVGTYSDGRVTYPLSTM VGRFDETAASVLFPDNPVARESVTAYLRAIRSVCMRIANGGTAERVGNVVALSPGRRNNIERMTWRSCRA GDFIDICNLKVANVTVDREA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3824c | papA1 | - | 100% (511) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA1 |
| M. tuberculosis H37Rv | Rv1182 | papA3 | e-157 | 55.96% (470) | polyketide synthase associated protein PapA3 |
| M. tuberculosis H37Rv | Rv3820c | papA2 | e-138 | 53.68% (462) | polyketide synthase associated protein PapA2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3854c | papA1 | 0.0 | 100.00% (511) | polyketide synthase associated protein |
| M. gilvum PYR-GCK | Mflv_0404 | - | 1e-135 | 49.58% (472) | condensation domain-containing protein |
| M. leprae Br4923 | MLBr_01230 | papA3 | 1e-159 | 55.48% (465) | PKS-associated protein, unknown function |
| M. abscessus ATCC 19977 | MAB_0938c | - | 1e-143 | 50.21% (472) | polyketide synthase associated protein PapA3 |
| M. marinum M | MMAR_2343 | - | 1e-139 | 51.68% (476) | hypothetical protein MMAR_2343 |
| M. avium 104 | MAV_1762 | - | 1e-150 | 53.39% (472) | condensation domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0409 | - | 1e-138 | 51.27% (472) | condensation domain-containing protein |
| M. thermoresistible (build 8) | TH_2204 | papA1 | 1e-149 | 55.20% (471) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN |
| M. ulcerans Agy99 | MUL_1531 | papA3 | 1e-132 | 49.59% (486) | polyketide synthase associated protein PapA3 |
| M. vanbaalenii PYR-1 | Mvan_0270 | - | 1e-134 | 50.21% (468) | condensation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3824c|M.tuberculosis_H37Rv -------------MRIGPVELSAVKDWDPAPGVLVSWHPTPASCAKALAA
Mb3854c|M.bovis_AF2122/97 -------------MRIGPVELSAVKDWDPAPGVLVSWHPTPASCAKALAA
Mflv_0404|M.gilvum_PYR-GCK -------------MRIGKITVGALEEWSLSPGKVISWHPTAASIEKARQA
Mvan_0270|M.vanbaalenii_PYR-1 -------------MRIGKITVGALDEWSLNPGSVTSWHPTAAAVETARRA
MSMEG_0409|M.smegmatis_MC2_155 -------------MRIGKITVGPLDEWSLKPGTVTSWQPTAAAREVARQA
MAB_0938c|M.abscessus_ATCC_199 MPERGRPSERDGVLRIGTITVGALDEWTLNAGTVTSWHPTPAATEKARQA
MAV_1762|M.avium_104 -------------MRIGKITIGSLGDWTPTPGPVTSWHPTAAAAEKVRQA
MLBr_01230|M.leprae_Br4923 -------------MQVGPLTLGTLLDWAPRAGKTISWQPTPATCEKVSQA
MMAR_2343|M.marinum_M ----------MKLVVLGNVGLETVSNWVPAPGLVWRWQPSSATLEKVRQA
TH_2204|M.thermoresistible__bu ------------MVALGNVAVETVREWRPDPGRVVSWDPSPAALEKARQA
MUL_1531|M.ulcerans_Agy99 ------------MVRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKA
: :* : .: :* .* *.*: .: . *
Rv3824c|M.tuberculosis_H37Rv PVSAVPPSYVQARQIRSFSEQAARGLDHSRLLIASVEVFGHCDLRAMTYV
Mb3854c|M.bovis_AF2122/97 PVSAVPPSYVQARQIRSFSEQAARGLDHSRLLIASVEVFGHCDLRAMTYV
Mflv_0404|M.gilvum_PYR-GCK PVSSVPVSYMQGQHLRNYCDRTTEGLNFSRQIIASCDVAGVCDIEAMDHA
Mvan_0270|M.vanbaalenii_PYR-1 QVSSVPVSYMQGQHLRNYWERTTAGLNFSRQIIASCEVPGQCDIAAMDHA
MSMEG_0409|M.smegmatis_MC2_155 PVSSVPVSYMQEQHLRNFCERTAAGLNFSRQIIASCEVPGQCDISAMDHA
MAB_0938c|M.abscessus_ATCC_199 PVSSVPVSYMQTQHLRNYYERNNAGLNFSRQIIASCDVPGNCDIAAMNHA
MAV_1762|M.avium_104 PASPVPVSYMQGQHLRNYHERTAAGLDFSRQIIATCDVPGRCDISAMNYA
MLBr_01230|M.leprae_Br4923 PVSSVPVAYMQAQHIRGYVEQKAKGLDYSRLMIVSCDQLGQCDIRAINYI
MMAR_2343|M.marinum_M PVSAVPPSHIQARHLRGFAEQTARGHDMSRLVVAAMDIPGECDIRAMTYV
TH_2204|M.thermoresistible__bu PVSSVPVSYMQAQHLRGFVEHAARGQEMSRLCIAAFDIPGRCDLRAMTYV
MUL_1531|M.ulcerans_Agy99 PISPVPPSYMQAHHLRNFRSYRERGLEMSRLLISSWDIPGICDIRTMTHV
*.** :::* :::*.: . * : ** : : : * **: :: :
Rv3824c|M.tuberculosis_H37Rv INAHLRRHDTYRSWFELRDTDHIVRHSIADPADIEFVPTTHGEMTSA-DL
Mb3854c|M.bovis_AF2122/97 INAHLRRHDTYRSWFELRDTDHIVRHSIADPADIEFVPTTHGEMTSA-DL
Mflv_0404|M.gilvum_PYR-GCK VNAYLRRHDTFRSWFEHSGDGEFVRRALVDPEDIEFVPVEHGHMGVD-EI
Mvan_0270|M.vanbaalenii_PYR-1 VNAYLRRHDTFRSWFERTEEGEFLRRAIADPADIEFVPIEHGDMTVD-EI
MSMEG_0409|M.smegmatis_MC2_155 VNSYLRRHDTFRSWFEDAGDGKFIRHSIENPDDIEFVPVEHGAMSID-EI
MAB_0938c|M.abscessus_ATCC_199 LNAYLRRHDTFRSWFERTDDGEFIRHSISDPADIEFAPVTQGHMSVD-EI
MAV_1762|M.avium_104 VNAYLRRHDTFRSWFHHSGDGEFVRHTVSNPADIEFAPIHHGEMTAE-EI
MLBr_01230|M.leprae_Br4923 VNAHLRRHDTYRSWFEYTDEGEIIRHTLCDPADIEFVPIEHGQLSLA-QI
MMAR_2343|M.marinum_M INSHLRRHDTYRSWFEFTESNRIARHTLTDPNDIELTPIEHGEMSPK-QW
TH_2204|M.thermoresistible__bu INAHMRRHDTYRSWFEYHDFHHIVRHTITDPADIELVPTRHGAMTPE-QW
MUL_1531|M.ulcerans_Agy99 VNAHMRRHDTFRSWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQW
:*:::*****:****. .: *::: * **::.. :* : :
Rv3824c|M.tuberculosis_H37Rv RQHIVATPDSLHWDCFSFGVIQRADSFTFYASIDHLHADGQFVGVGLMEF
Mb3854c|M.bovis_AF2122/97 RQHIVATPDSLHWDCFSFGVIQRADSFTFYASIDHLHADGQFVGVGLMEF
Mflv_0404|M.gilvum_PYR-GCK HAHVVAIPSPLEWGCFTFGVIQNDDHFSFFASMDHVHGDATLIGTTMMEA
Mvan_0270|M.vanbaalenii_PYR-1 FAHVVDIPSPLEWGCFTFGVIQHDGHFTFFASMDHVHGDATLIGTTMMEA
MSMEG_0409|M.smegmatis_MC2_155 HAHVTDIPTPLEWACFTFGVIQSEDHFTFFAAMDHVHGDATLIGTTMLEA
MAB_0938c|M.abscessus_ATCC_199 RSHVIDIPSPLEWGCFTFGIIQSENHFTFFAAMDHVHGDATLIGTTMMEA
MAV_1762|M.avium_104 RAHVVAIPNPLEWGCFTFGVVQNEEYFTFFAAMDHVHGDATLIGTTMLEA
MLBr_01230|M.leprae_Br4923 RELAVSTPDPLEWGCFQFGVIQAEEHFTFYASIDHVHVDAMIVGVTLMEF
MMAR_2343|M.marinum_M QDYILATPGPLEWDCFRFAIIQRDDHFTFCVSVDHLNVDAMFISAVFWEI
TH_2204|M.thermoresistible__bu QQHLLSTPDPLQWNCFRFSIIQRSDHFTFCVCMDHVHIDAMFMGAVFMEI
MUL_1531|M.ulcerans_Agy99 RERLLATPSPLEWGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEI
* .*.* *. *.::* *:* ..:**:: *. ::.. : *
Rv3824c|M.tuberculosis_H37Rv QSMYTALIMGEPPIGLSEAGSYVDFCVRQHEYTSALTVDSPEVRAWIDFA
Mb3854c|M.bovis_AF2122/97 QSMYTALIMGEPPIGLSEAGSYVDFCVRQHEYTSALTVDSPEVRAWIDFA
Mflv_0404|M.gilvum_PYR-GCK NGMYSALSSGGAALALPDAGSFDDFCVREREYTAELTEDSPGVRAWIEFA
Mvan_0270|M.vanbaalenii_PYR-1 NGMYSALSGGGAALTLPDAGSFDEFCVRERAHTSELTEDSPEVRAWIEFA
MSMEG_0409|M.smegmatis_MC2_155 NGMYSALSGGGEALVLPEAGSFDDFCIRERERTADLTVDSPEVRAWIEFA
MAB_0938c|M.abscessus_ATCC_199 NGMYSALSSGGAALTLPDAGSFDDFCTREREFTSALTLDSPGVQAWIDFA
MAV_1762|M.avium_104 NGMYAAASAGSEPLELPDAGSFDDFCAREREYTSALTVDSPEVRAWIDFA
MLBr_01230|M.leprae_Br4923 HMMYSALVSGAGPLELPEAGSYDDFCRRQHRFTSMLTAESPQIRSWTQFA
MMAR_2343|M.marinum_M EAMYNTLADGGAPISLPEAGSYGEYCLRERAYTSALTLESPEVRQWIDFF
TH_2204|M.thermoresistible__bu HMQYAALVGGGAPIPL-QAGSYDDFCVRQRQYTESLTADSPEVRAWVDFA
MUL_1531|M.ulcerans_Agy99 HLMYLALVSGGAPLRLAEPGSYDNYCNRQREHISGLTLDSPVMSKWTEFF
. * : * .: * :.**: ::* *:: ** :** : * :*
Rv3824c|M.tuberculosis_H37Rv EINNGTFPEFPLPLGDPSVRCGGDLLSMMLMDEQQTQRFESACMAANARF
Mb3854c|M.bovis_AF2122/97 EINNGTFPEFPLPLGDPSVRCGGDLLSMMLMDEQQTQRFESACMAANARF
Mflv_0404|M.gilvum_PYR-GCK ENNSDGFPEFPLPLGNPKDSTRSVMTSAVLMDTAQTERFDAAATAAGARF
Mvan_0270|M.vanbaalenii_PYR-1 ENSGGGFPEFPLPLGNPAESTRSCMTSEILMDTAQTERFESACTAAGARF
MSMEG_0409|M.smegmatis_MC2_155 EDNNGGFPEFPLPLGNPKKSTSSDMTSEILLDPAQTERFESACNAAGARF
MAB_0938c|M.abscessus_ATCC_199 ENNNGTFPEFPLPLGNPAEATNSTMTSLLLLNPEQTDRFDAACGTAGARF
MAV_1762|M.avium_104 ENNNGSFPEFPLPLGNPSEATASAMVSELVMDAEQTERFESACTAVGVRF
MLBr_01230|M.leprae_Br4923 EPNEGSFPDFPLPLGDPLEPTQADIVTITMLDEQQTDRFEAACTVAGARF
MMAR_2343|M.marinum_M ESNDGALPSFPLPLGDLSLVDTGELLSLQLMDAGQTARFEAACTSAGARF
TH_2204|M.thermoresistible__bu GQMGGTLPNFPLPLGDRTKPWPGELMVVKLLDGRQTDRFEAACVSAGARF
MUL_1531|M.ulcerans_Agy99 DNNDGSLPKFPLPLGDTS--AQCEMMGVRLMDERQTLALEAACMSAGARF
. :*.******: : ::: ** :::*. ...**
Rv3824c|M.tuberculosis_H37Rv IGGMLACIAIAIHELTGADTYFGITPKDIR-TPADLMTQGWFTGQIPVTV
Mb3854c|M.bovis_AF2122/97 IGGMLACIAIAIHELTGADTYFGITPKDIR-TPADLMTQGWFTGQIPVTV
Mflv_0404|M.gilvum_PYR-GCK VGGLFACLAQVEHELTGALTYYGLTPRDSRSGSDNFMTQGWFTGLIPITV
Mvan_0270|M.vanbaalenii_PYR-1 VGGLFACLAQVEHELTGALTYYGLTPRDSRSASDNFMTQGWFTGLIPITV
MSMEG_0409|M.smegmatis_MC2_155 VGGLFACLAQVEHELTGALTYYGLTPRDSRNATDNFMTQGWFTGLIPITV
MAB_0938c|M.abscessus_ATCC_199 VGGLFACLGLVEHEFTGAVTYYGLTPRDSRTASDNFMTQGWFTGLIPITV
MAV_1762|M.avium_104 IGGLFACIALVEHELTGALTYYGLTPRDTRRTTDNFMTQGWFTGLVPITV
MLBr_01230|M.leprae_Br4923 VGGVLACCGLAEYELTGADTYYGLTPRDTRRIPTDVLTQGWFTGLVPITV
MMAR_2343|M.marinum_M SGGVFACAALAEYELTGSRTYYAVTPTSTRSTPAEFMTTGWFVGHIPFTV
TH_2204|M.thermoresistible__bu VGGVFACAALTENELAGVETFHAITPTDTRSTPADFMTTGWFTGMVPITV
MUL_1531|M.ulcerans_Agy99 CGGVFAISAVVQHELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITV
**::* . . *::* :..:.* . * :.:* ***.* :*.**
Rv3824c|M.tuberculosis_H37Rv PVAGLSFNEIARIAQTSFDTGADLAKVPFERVVELSPSLRRPQPLF--SL
Mb3854c|M.bovis_AF2122/97 PVAGLSFNEIARIAQTSFDTGADLAKVPFERVVELSPSLRRPQPLF--SL
Mflv_0404|M.gilvum_PYR-GCK PIGAASFGEAAWAAQSSFDSGLNMAKVPYYRVLELAPWLGWPRPNF--PV
Mvan_0270|M.vanbaalenii_PYR-1 PIGATSFADAAWAAQASFDSNLFMAKVPYYRVLELAPWLSWPRPNF--PV
MSMEG_0409|M.smegmatis_MC2_155 PIGAASFTEAAGSAQRSFDANLNMAKVPYYRVLELAPSLRWPQPNF--PV
MAB_0938c|M.abscessus_ATCC_199 PIAATSFNDAAYAAQTAFDSSLDMARVPYYRVLELAPWLKWPEPNF--PV
MAV_1762|M.avium_104 PIAAASFADAAWTAQTSFDSGQQLAKVPYYRVLELAPWLKWPQPNF--PV
MLBr_01230|M.leprae_Br4923 PIAGSSFGDAARAAQNCFDTDVHLAEVPYDRVVELAPTVHKPRPNF--PV
MMAR_2343|M.marinum_M AVA-SSFDETVRGAQANFDASAHLANVPFERVLELAPWLKKPPPRGGFPM
TH_2204|M.thermoresistible__bu PAAGVSFGEAARAAQQSFDSGIGLGHVPYDRVLELVPSLRRAETCS--PM
MUL_1531|M.ulcerans_Agy99 PTVGSSFGEIVKAAQGSFDSGRDLAEVPLDCVMELVLWLREGQWGA--PL
. ** : . ** **:. :..** *:** : .:
Rv3824c|M.tuberculosis_H37Rv VNFFDAQVGPLSAVTKLFEG---LNVGTYSDGRVTYPLSTMVGRFDE-TA
Mb3854c|M.bovis_AF2122/97 VNFFDAQVGPLSAVTKLFEG---LNVGTYSDGRVTYPLSTMVGRFDE-TA
Mflv_0404|M.gilvum_PYR-GCK SNFFHGGAAPLNAILAASEMGLADNIGIYPDGRFSYQLTIYIFRYGQGTE
Mvan_0270|M.vanbaalenii_PYR-1 SNFFHGGAAPLNAILAAADMGLANNIGIYPDGRFSYQLTIYIFRYGEGTV
MSMEG_0409|M.smegmatis_MC2_155 SNFFHGGAAPLNAVLAAADMGLANNIGIYPDGRYSYQLTIYIFRYGEGTA
MAB_0938c|M.abscessus_ATCC_199 SNFFHGGAAPLNAILAAGELGLADNIGIYPDGRFSYQLTIYIFRYGEGTA
MAV_1762|M.avium_104 SNFFHAGAAPLNAVLAAADLGYANNIGIYSDGRYSYQLTIYVFRYGEGTA
MLBr_01230|M.leprae_Br4923 INFLDAGTAPLSVLLTAGLDGLN--IGVYSDGRYSYQMSIYVIRVEQETA
MMAR_2343|M.marinum_M VSFLDGGVPPLSGVVAMQLDR--INARAFSDGRVAARVCIWVNKFQEETT
TH_2204|M.thermoresistible__bu MSFLDAGVPPLSALVASQLDG--LNARVYGDGKVPAQLCMWVNRMDNETS
MUL_1531|M.ulcerans_Agy99 LFYLDAGIPPLSAMANSHVEG--LRARLCHDGGMMGQIDIRVNRLEKETQ
::.. **. : ** : : : : *
Rv3824c|M.tuberculosis_H37Rv ASVLFPDNPVARESVTAYLRAIRSVCMRIANGGTAERVGNVVALSPGRRN
Mb3854c|M.bovis_AF2122/97 ASVLFPDNPVARESVTAYLRAIRSVCMRIANGGTAERVGNVVALSPGRRN
Mflv_0404|M.gilvum_PYR-GCK MAIMHPDNPVAKRSVERYMQTMSSVASLVADTGHWGRVA-----------
Mvan_0270|M.vanbaalenii_PYR-1 MAIMHPDNPVAKKSVTRYMKVMKSVAGLVADSGTWGLVA-----------
MSMEG_0409|M.smegmatis_MC2_155 MAIMHPDNSVARKSATRYMETMRSVAGQVADSGNWGRVA-----------
MAB_0938c|M.abscessus_ATCC_199 MAIMHPDNPIAEKSALRYMEAMKSVCARVADTGHWGRVA-----------
MAV_1762|M.avium_104 MAMMYPDNPVAHKSVARYTETMRSVCGRVADTGHWGRVA-----------
MLBr_01230|M.leprae_Br4923 VAVMFPDNPEAQESVARYLETLKSVFECVAESGHWRNVA-----------
MMAR_2343|M.marinum_M VTASFPNNPIAYDSVARYLDTMKSVYLRIAEG------ARWDAIAQVL--
TH_2204|M.thermoresistible__bu VTVFFPDNPVARASVEKYVATLRSIYVAVAEGRADRLGARRSGELQRQPA
MUL_1531|M.ulcerans_Agy99 LTVLFPNNPVARESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLAY
: .*:*. * *. * .: * :*:
Rv3824c|M.tuberculosis_H37Rv NIERMTWRSCRAGDFIDICNLKVANVTVDREA
Mb3854c|M.bovis_AF2122/97 NIERMTWRSCRAGDFIDICNLKVANVTVDREA
Mflv_0404|M.gilvum_PYR-GCK --------------------------------
Mvan_0270|M.vanbaalenii_PYR-1 --------------------------------
MSMEG_0409|M.smegmatis_MC2_155 --------------------------------
MAB_0938c|M.abscessus_ATCC_199 --------------------------------
MAV_1762|M.avium_104 --------------------------------
MLBr_01230|M.leprae_Br4923 --------------------------------
MMAR_2343|M.marinum_M --------------------------------
TH_2204|M.thermoresistible__bu --------------------------------
MUL_1531|M.ulcerans_Agy99 SRRTYEPPATVSPLTSWRTG------------