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DLMMPNDSMFLFIESREHPMHVGGLSLFEPPQGAGPEFVREFTERLVANDEFQPMFRKHPATIGGGIARV AWAYDDDIDIDYHVRRSALPSPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHAL IDGVSAMKLAQRTLSADPDDAEVRAIWNLPPRPRTRPPSDGSSLLDALFKMAGSVVGLAPSTLKLARAAL LEQQLTLPFAAPHSMFNVKVGGARRCAAQSWSLDRIKSVKQAAGVTVNDAVLAMCAGALRYYLIERNALP DRPLIAMVPVSLRSKEDADAGGNLVGSVLCNLATHVDDPAQRIQTISASMDGNKKVLSELPQLQVLALSA LNMAPLTLAGVPGFLSAVPPPFNIVISNVPGPVDPLYYGTARLDGSYPLSNIPDGQALNITLVNNAGNLD FGLVGCRRSVPHLQRLLAHLESSLKDLEQAVGI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3734c | - | - | 100% (454) | hypothetical protein Rv3734c |
| M. tuberculosis H37Rv | Rv3740c | - | e-162 | 61.42% (451) | hypothetical protein Rv3740c |
| M. tuberculosis H37Rv | Rv0895 | - | 3e-91 | 40.94% (469) | hypothetical protein Rv0895 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3761c | - | 0.0 | 100.00% (454) | hypothetical protein Mb3761c |
| M. gilvum PYR-GCK | Mflv_1058 | - | 2e-88 | 40.17% (463) | hypothetical protein Mflv_1058 |
| M. leprae Br4923 | MLBr_01244 | - | 2e-26 | 27.10% (369) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_4544c | - | 1e-129 | 51.31% (458) | hypothetical protein MAB_4544c |
| M. marinum M | MMAR_5271 | - | 0.0 | 85.46% (454) | hypothetical protein MMAR_5271 |
| M. avium 104 | MAV_0355 | - | 0.0 | 73.73% (453) | bifunctional wax ester synthase/acyl-coadiacylglycerol |
| M. smegmatis MC2 155 | MSMEG_6322 | - | 1e-178 | 67.62% (454) | bifunctional wax ester synthase/acyl-CoA diacylglycerol |
| M. thermoresistible (build 8) | TH_2030 | - | 1e-169 | 66.08% (454) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1193 | - | 1e-172 | 65.86% (454) | hypothetical protein MUL_1193 |
| M. vanbaalenii PYR-1 | Mvan_5773 | - | 3e-86 | 39.05% (461) | hypothetical protein Mvan_5773 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1058|M.gilvum_PYR-GCK MSANSVRLGLQDLM----FIYGETSSSKMHVGGLLPFTPP-ADAPRDYLR
Mvan_5773|M.vanbaalenii_PYR-1 -------------M----FIYGETSSSKMHVAGLLPFTPP-ADAPRDYLR
Rv3734c|M.tuberculosis_H37Rv ----MDLMMPNDSM----FLFIESREHPMHVGGLSLFEPP-QGAGPEFVR
Mb3761c|M.bovis_AF2122/97 ----MDLMMPNDSM----FLFIESREHPMHVGGLSLFEPP-QGAGPEFVR
MMAR_5271|M.marinum_M ----MELMMPTDSM----FLFVESREHPMHVGGLSLFEPP-EGAGPDFVR
MAV_0355|M.avium_104 ----MELIMPTDAV----FLLGESREHPMHVGGLQLYQPP-EGAGRNFVR
MSMEG_6322|M.smegmatis_MC2_155 -MNRMQLMSPTDSM----FLIAESREHPMHVGGLALYDPP-DDAGPEFVR
TH_2030|M.thermoresistible__bu ----MRLISPADSM----FLLAESREHPMHVAGLQLFEPPPGTAGPEFLQ
MUL_1193|M.ulcerans_Agy99 ----MELMMPTDAS----FLFTESREHPMHVAGLQLFDPP-DAAGPGFVD
MAB_4544c|M.abscessus_ATCC_199 ----MPFMPVSDSM----FLIGETREHPFHVGGLQLFKPP-VDAGPDYAE
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELL--DTTPDWNR
:: . .*: : :
Mflv_1058|M.gilvum_PYR-GCK GMIDEARRQEVVAPWNRRLAYPRLQFSPLHSWVTDEDFDFDYHVRRSALA
Mvan_5773|M.vanbaalenii_PYR-1 RMVDDARRQEVMPPWNRKLAYPRLQFSPLHTWVTDTEFDFDYHVRRSALA
Rv3734c|M.tuberculosis_H37Rv EFTERLVANDEFQPMFRKHPATIGGGIARVAWAYDDDIDIDYHVRRSALP
Mb3761c|M.bovis_AF2122/97 EFTERLVANDEFQPMFRKHPATIGGGIARVAWAYDDDIDIDYHVRRSALP
MMAR_5271|M.marinum_M NFYEALVANHEFQPTFRKHPATIGGGIARVAWAYDDDLDVDYHVRRSALP
MAV_0355|M.avium_104 DFYKQLVAQPDFQPTFRKHPAKFVGGIANLGWSYDADVDVDYHVRRSALP
MSMEG_6322|M.smegmatis_MC2_155 ELYEEMVRHTDFQPVFRKHPATLLGGIANVGWTLDDEVDLDYHLRRSALP
TH_2030|M.thermoresistible__bu GLHQRLAAGRELHPTFRKHPATLFGGIAHLGWAVDDDVDFDYHLRRSALP
MUL_1193|M.ulcerans_Agy99 EIYRCLAANREGQPAFRKHPATLLGGITNLGWQYDNEIDTDYHVRRSVLP
MAB_4544c|M.abscessus_ATCC_199 VFYEQLMSTTEVSSDFRKRPGQPLAVMGNLTWIVDDEVDWEYHVRRSALP
MLBr_01244|M.leprae_Br4923 -FRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHVRRVRVP
: *: * * :.: ::*:** :.
Mflv_1058|M.gilvum_PYR-GCK SPGDERELGVLVSRLHSNHLDLTRPPWELHVIEGLEGGRFALYMKIHHAL
Mvan_5773|M.vanbaalenii_PYR-1 SPGDERELGILVSRLHSNHLDLTRPPWELHVIEGLEGGRFALYMKIHHAL
Rv3734c|M.tuberculosis_H37Rv SPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHAL
Mb3761c|M.bovis_AF2122/97 SPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHAL
MMAR_5271|M.marinum_M SPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLSDGRFAMYAKMHHAL
MAV_0355|M.avium_104 SPRRVRELLELTSRWHSSLLDRHRPLWETHIVEGLKDGRFAIYTKVHHAL
MSMEG_6322|M.smegmatis_MC2_155 SPGRPRELLELTSRVHGTLLDRHRPLWEAYLIEGMADGRFAVYTKVHHSL
TH_2030|M.thermoresistible__bu GPGRIRELLDLTSRWHGTLLDRHRPLWEVHLVEGLADGRVAIYFKVHHAL
MUL_1193|M.ulcerans_Agy99 YPGRVRELLQLVSQLHSHLLDRHYPLWEMHVVDGLADGRFAIYSKFHHAL
MAB_4544c|M.abscessus_ATCC_199 RPARVRELLTVTSRWHSSPLDRHRPLWEMHVVEGLSDGRLAVYTKMHHAV
MLBr_01244|M.leprae_Br4923 DPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLLQISHAI
* *:: :.. : :* * * :::*: ** *: :. *::
Mflv_1058|M.gilvum_PYR-GCK VDGYSAMRMLGRSLSTDPASRDTRMFFNVPSPTRSRRDPGAAESSNPLTA
Mvan_5773|M.vanbaalenii_PYR-1 VDGYTAMRMLGRSLSTDPETRDARMFFNVPIPKRSRPTGAGAQSSNPVTA
Rv3734c|M.tuberculosis_H37Rv IDGVSAMKLAQRTLSADPDDAEVRAIWNLPPRPRTRPPS-------DGSS
Mb3761c|M.bovis_AF2122/97 IDGVSAMKLAQRTLSADPDDAEVRAIWNLPPRPRTRPPS-------DGSS
MMAR_5271|M.marinum_M IDGVSAAKLMQRTMSADPSDTEVRAMWNLPRPPRPESNG-------GGSS
MAV_0355|M.avium_104 IDGVSAQKLMQRALSSDPDDPEIRAPWTLPKRSRKAGP----------SS
MSMEG_6322|M.smegmatis_MC2_155 IDGVSAMKLVERTLSEDPSDTTVRVPWNLP-RRESSRRA-------GSSS
TH_2030|M.thermoresistible__bu IDGVAVMKLMQRTLSTDPGDD-ARVPWNLP-PPRRNP-A-------GPVS
MUL_1193|M.ulcerans_Agy99 LDGASALMLLQRALSDDPRDTEVRAPWNLPPQPDHAVG----------SS
MAB_4544c|M.abscessus_ATCC_199 IDGVGALRMMMRSLSDDPDARDCQAVWAPAKRRAKSSIVSTTNT--SAID
MLBr_01244|M.leprae_Br4923 TDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQGINHLPVA
** : . . :
Mflv_1058|M.gilvum_PYR-GCK TLRALGGVSSAVTGGVSSAVDLTNALVNTQIRRDGENAHIAGSVSAPHSI
Mvan_5773|M.vanbaalenii_PYR-1 TLRALGAVGSTVSDGVGSAVDLASALVNTQIRRDGDFGRISGSASAPHSI
Rv3734c|M.tuberculosis_H37Rv LLDALFKMAGSVVGLAPSTLKLARAALLEQQ--------LTLPFAAPHSM
Mb3761c|M.bovis_AF2122/97 LLDALFKMAGSVVGLAPSTLKLARAALLEQQ--------LTLPFAAPHSM
MMAR_5271|M.marinum_M LVGSLVKMAGSVAGLAPSTLKLARAALFEQQ--------LTLPFAAPHTM
MAV_0355|M.avium_104 RLSSLVHAAGSVAALAPSTVSLARAALVEQQ--------LTLPFGAPRTM
MSMEG_6322|M.smegmatis_MC2_155 LARTATGAATSLAALAPSTIRLARAALLEQQ--------LTLPFGAPRTM
TH_2030|M.thermoresistible__bu RLRSATGAVGSVAALAPSTLSLARAALLEQR--------LTLPFGAPRTM
MUL_1193|M.ulcerans_Agy99 RLGSLANTAGSLMALGPSTVSLIRAALVEQQ--------LTLPFGAPRTL
MAB_4544c|M.abscessus_ATCC_199 LVKGAAGAVRQVVSIPPGLLKYGRHALSDPQ--------LVKPLSAPHTM
MLBr_01244|M.leprae_Br4923 LAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQAAEPSPL
: : : : . * .:
Mflv_1058|M.gilvum_PYR-GCK LNARISRNRRFATQQYEFDRLKKLSSQHGATLNDVALAIIGGGLRKFLSD
Mvan_5773|M.vanbaalenii_PYR-1 LNARISRNRRFATQQYEFDRLKKLSSQHGATINDVALAIIGGGLRKFLAD
Rv3734c|M.tuberculosis_H37Rv FNVKVGGARRCAAQSWSLDRIKSVKQAAGVTVNDAVLAMCAGALRYYLIE
Mb3761c|M.bovis_AF2122/97 FNVKVGGARRCAAQSWSLDRIKSVKQAAGVTVNDAVLAMCAGALRYYLIE
MMAR_5271|M.marinum_M FNVKVGGARRCAAQSWSLERIRAVKQAAGVTVNDAVLAMCAGALRYYLIE
MAV_0355|M.avium_104 LNVKIGGARRCAAQSWPLERIKNVKNAAGVTVNDVVLAMCSGALRYYLLE
MSMEG_6322|M.smegmatis_MC2_155 FNVKIGGARRVAAQSWPLERLRRIKAVTGATINDIVLAMCAGALRAYLAE
TH_2030|M.thermoresistible__bu FNVRIGGARRVAAQSWPLQRIRRIRQAAGXTLNDVALAMCAGALRQYLLE
MUL_1193|M.ulcerans_Agy99 FNVKVGGARRCAAQSWSLDRFRAVAKCAGVTINDVVLAMCAGALRQYLLE
MAB_4544c|M.abscessus_ATCC_199 LNVSIGGARRFAAQTWSMARIKEAGKALGGTVNDVVLAMCGGALRTYLEE
MLBr_01244|M.leprae_Br4923 LRQRS-LATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALRRYH-E
:. * : : :: . ::** ** *.** : :
Mflv_1058|M.gilvum_PYR-GCK FDKLPDRSLIAFLPVNVRPKGD-EGGGNAVGAILAPMGTDIEDPVERLDT
Mvan_5773|M.vanbaalenii_PYR-1 LGELPDRSLIAFLPVNVRPKGD-EGGGNAVGAILAPMGTDIEDPVERLAV
Rv3734c|M.tuberculosis_H37Rv RNALPDRPLIAMVPVSLRSKEDADAGGNLVGSVLCNLATHVDDPAQRIQT
Mb3761c|M.bovis_AF2122/97 RNALPDRPLIAMVPVSLRSKEDADAGGNLVGSVLCNLATHVDDPAQRIQT
MMAR_5271|M.marinum_M QDALPDAPLIAMVPVSLRSKEQADSGGNMVGSVLCNLGTNVEDPAQRIEI
MAV_0355|M.avium_104 QNALPDTPLIAMVPVSLRTEEEADAGGNLVGAILCNLATDSDDPAQRLLT
MSMEG_6322|M.smegmatis_MC2_155 QDALPDRPLIAMVPVSMRSEHEADAGGNMVGSILCSLGTDVEDPADRLAV
TH_2030|M.thermoresistible__bu HDALPATPLVAMVPVSLRSADESAGGGNRTGLVLCNLATDSDDPAERLDR
MUL_1193|M.ulcerans_Agy99 QNALPDAPLVALVPVSLRSQTD-DSGDTMVGTVLCGLATDTTDPAKRLEM
MAB_4544c|M.abscessus_ATCC_199 QNALPDKPLVAMCPVSIRAEGDQNAGNSIT-ALLANLATDKPDPLERFSA
MLBr_01244|M.leprae_Br4923 ALGVSISTLPMAVPVNVRTEADVVGSNRFVGVTLAAPLG-TNDPAARMQK
:. .* **.:*. : ... . *. ** *:
Mflv_1058|M.gilvum_PYR-GCK ITTATRAAKGQLQSMSPAAIIAYSAALLAPAGSQIAGALTGVQPPWPYTF
Mvan_5773|M.vanbaalenii_PYR-1 ITAATRASKAQLQSMSPAAIIAYSAALLAPAGGQIAGALTGVNPPWPHTF
Rv3734c|M.tuberculosis_H37Rv ISASMDGNKKVLSELPQLQVLALSALNMAPL--TLA-GVPGFLSAVPPPF
Mb3761c|M.bovis_AF2122/97 ISASMDGNKKVLSELPQLQVLALSALNMAPL--TLA-GVPGFLSAVPPPF
MMAR_5271|M.marinum_M ISASMRANKKVLADLPRLQVLALSGLNMAPL--TLA-GVPGFLSTVPPPF
MAV_0355|M.avium_104 ISESMRSNKKVFSQLPRFQALALSAANLSSL--ALA-AVPGWVSATSPPF
MSMEG_6322|M.smegmatis_MC2_155 IRRSITDNKRVFSELPRLQALALSALLIAPL--GLTTAFPGFVDATAPPF
TH_2030|M.thermoresistible__bu ISSSMRSNKRVFSQLPRVQAMALSAAMIAPL--GLG-AVPGVVSSAPPPF
MUL_1193|M.ulcerans_Agy99 ISQSMRRNKKAFSELSPLQAKALWAFNMAPL--TLT-AVPGFVPWTKPSF
MAB_4544c|M.abscessus_ATCC_199 IRDSVQAAKSVLSEMTPLQRMLVGALNGAPV--LTG-AVPGLVDRTAPAF
MLBr_01244|M.leprae_Br4923 IRSQMTQRR----DEPAMNIIGS----LAPLMTVLPASVLDFIVDSVASS
* : . . :. .. . .
Mflv_1058|M.gilvum_PYR-GCK NLCVSNVPGPREPLYFNGSRLEATYPVSIPIHGMALNITLQSYADTMNLG
Mvan_5773|M.vanbaalenii_PYR-1 NLCVSNVPGPREPLYFNGSRLEATFPVSIPIHGMALNITLQSYADTMNLG
Rv3734c|M.tuberculosis_H37Rv NIVISNVPGPVDPLYYGTARLDGSYPLSNIPDGQALNITLVNNAGNLDFG
Mb3761c|M.bovis_AF2122/97 NIVISNVPGPVDPLYYGTARLDGSYPLSNIPDGQALNITLVNNAGNLDFG
MMAR_5271|M.marinum_M NIVISNVPGGAQPLYYGGARLDGSYPLSNIPDGQALNITLVNNADRLDFG
MAV_0355|M.avium_104 NIVISNVPGPTAPLYYGGARLDGNYPLSIVLDGQALNITLASNAGNLDFG
MSMEG_6322|M.smegmatis_MC2_155 NLVISNVPGPKKPLYWRGARLAGNYPLSIALDGQALNMTVVSNAHNLDFG
TH_2030|M.thermoresistible__bu NLVISNVPGAPEPRYWMGARLAGNYPLSIVLDGQALNITLVTNADNLDFG
MUL_1193|M.ulcerans_Agy99 NVIVSNLPGPTKPMYWHGARLDSIYPLSIAHDGQALSITLLSNAGTLEFG
MAB_4544c|M.abscessus_ATCC_199 NVIISNVPGPRTDMFWNGFEMDGCYPASIPIDGVALNITCTSSGSSMHFG
MLBr_01244|M.leprae_Br4923 DVNASNIPAYPGDTYFAGAKILRQYGIGPRP-GVAMMAVLMSRGGFCTVT
:: **:*. :: .: : . * *: . . . .
Mflv_1058|M.gilvum_PYR-GCK FVGCRDRLPHLQRLAVYTGDALAELEAASQI-------------------
Mvan_5773|M.vanbaalenii_PYR-1 FVGCRDRLPRLQRLAVYTGDALGELEAASS--------------------
Rv3734c|M.tuberculosis_H37Rv LVGCRRSVPHLQRLLAHLESSLKDLEQAVGI-------------------
Mb3761c|M.bovis_AF2122/97 LVGCRRSVPHLQRLLAHLESSLKDLEQAVGI-------------------
MMAR_5271|M.marinum_M LVGCRRSVPSLQRLLGHLETSLKDLEQAVGV-------------------
MAV_0355|M.avium_104 LVGCRRSVPHLQRLLMHLESSLKDLERAVGE-------------------
MSMEG_6322|M.smegmatis_MC2_155 LVGCRRSVPHLQRLLGHLETSLKDLETATGA-------------------
TH_2030|M.thermoresistible__bu LVGARGSVPHLQRLLGHLEDSLQQLERAVGG-------------------
MUL_1193|M.ulcerans_Agy99 LVGCRRSVPHLQRLLLHLETSLYGLEQAVGL-------------------
MAB_4544c|M.abscessus_ATCC_199 LTGCRTSVPHLQRILAHLEDALTQLEESVA--------------------
MLBr_01244|M.leprae_Br4923 VRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAARSSGSPA
. * : : .: :
Mflv_1058|M.gilvum_PYR-GCK ------
Mvan_5773|M.vanbaalenii_PYR-1 ------
Rv3734c|M.tuberculosis_H37Rv ------
Mb3761c|M.bovis_AF2122/97 ------
MMAR_5271|M.marinum_M ------
MAV_0355|M.avium_104 ------
MSMEG_6322|M.smegmatis_MC2_155 ------
TH_2030|M.thermoresistible__bu ------
MUL_1193|M.ulcerans_Agy99 ------
MAB_4544c|M.abscessus_ATCC_199 ------
MLBr_01244|M.leprae_Br4923 GWLSSS