For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VRHPEKSPIPHVVIAGAGIAGMAAAMILAEAGVRVTVCEAAPEAGGKAKSLRRPDGHPTEHSLRVYLDYY QTLLTLFLRIPTESGKTVLDNLVGVNAVRVYRHRTFGRAAAPAPARRRRTTFALLARVFEPLAQFSRMVV RSALVIVGMASRGVSPIDAIRYLHAHVRLLWMCPERLTAELADVAYEDYLQLGKKAPRAQAFFSALPRIF VAARPNAEAAAIAPIILKGLFHFTSRPAALNGITAPSIMMMNGPTSERMVDPWIRHLQTLGVDLKFDTRI DDLEFRDGRVTALVSADGRRFGCDFAVLALPYLTLRRLAERDCVSRHLPHLTQQHAIALESSNGLQFFLR DIPPTWPAHVRPGVVGTHFESEWALVSVLQGEGFWADVALPAGTKYVLSITWSDVDTPGPVFGRPASECT PDEIATECLAQCGLDRSHIAGWHIDDELKHLSEADYQSLASDLPPHLASAPARGQRMVNLSPLTILLPGA RDRSPRIRTEVGNLFLAGEASYSPELTFLVPTMEKAASSGYLAAHNILGVGAADAAPELRIDFNDPVPFA GLRRVDRWFWNRRRPPESPCDPPGAACPSENGVPHGCPTPVPHPESAPRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2963 | - | - | 100% (610) | oxidoreductase |
| M. marinum M | MMAR_1580 | - | 4e-05 | 55.26% (38) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3754 | - | 0.0 | 68.78% (583) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4235 | - | 1e-05 | 44.23% (52) | hypothetical protein Mflv_4235 |
| M. tuberculosis H37Rv | Rv3727 | - | 0.0 | 68.95% (583) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | MAV_4796 | - | 1e-13 | 24.79% (609) | FAD dependent oxidoreductase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2347 | - | 1e-05 | 53.66% (41) | phytoene dehydrogenase |
| M. thermoresistible (build 8) | TH_1483 | - | 1e-07 | 35.92% (142) | dehydrogenase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4388 | - | 3e-05 | 56.76% (37) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3754|M.bovis_AF2122/97 ------------------------MKPSPAD--THVVIAGAGIAGLAAAM
Rv3727|M.tuberculosis_H37Rv ------------------------MKPSPAD--THVVIAGAGIAGLAAAM
MMAR_2963|M.marinum_M ------------------------MRHPEKSPIPHVVIAGAGIAGMAAAM
MAV_4796|M.avium_104 -------------------MSEHIRTPASQARRPTVAVLGAGIAGLTAAH
TH_1483|M.thermoresistible__bu ---------LTDPRRVHHHAPPGLPDARGLARRPHVVVVGAGIAGLAAAT
MSMEG_2347|M.smegmatis_MC2_155 ------------------------MSRAIPGPTDHVVVVGAGLSGLSAAL
Mflv_4235|M.gilvum_PYR-GCK ---------------------------MGSNGQVELTVVGSGPNGLAAAV
Mvan_4388|M.vanbaalenii_PYR-1 MLALTRRQFTLGLGAVAATPLLTSCGGGGDTTRGHVVVVGAGMSGLAAAR
:.: *:* *::**
Mb3754|M.bovis_AF2122/97 ILAEAGVRVTLCEAASEAG--------GKAKSLRLADGHPTEHSLRVYTD
Rv3727|M.tuberculosis_H37Rv ILAEAGVRVTLCEAASEAG--------GKAKSLRLADGHPTEHSLRVYTD
MMAR_2963|M.marinum_M ILAEAGVRVTVCEAAPEAG--------GKAKSLRRPDGHPTEHSLRVYLD
MAV_4796|M.avium_104 ELAERGFVVTVYEAQQDERNGLGSAPAGTYPPVKLGGLAASQYSTVGTHD
TH_1483|M.thermoresistible__bu GLAERGVTVDVVEQAGYLG--------GRVGGWT-EDIGPDVPGGAAMNR
MSMEG_2347|M.smegmatis_MC2_155 HLAGRGRRVTVVEREPWPG--------GRAGRIDTGGYRIDTGPTVLTMP
Mflv_4235|M.gilvum_PYR-GCK ICARAGVSVRVVEAQPTAG--------GGARTLPDPEFSGVSHDICSAVH
Mvan_4388|M.vanbaalenii_PYR-1 RLTDAGVPVTVVEARSRIG----------GRTWTDTSLGLPVDLGAAWIH
: * * : *
Mb3754|M.bovis_AF2122/97 TYQTLLTLFSRIPTEHDR--TMLDNLVGVSMVSATAQGVIGRIAAPVALQ
Rv3727|M.tuberculosis_H37Rv TYQTLLTLFSRIPTEHDR--TVLDNLVGVSMVSATAQGVIGRIAAPVALQ
MMAR_2963|M.marinum_M YYQTLLTLFLRIPTESGK--TVLDNLVGVNAVRVYRHRTFGRAAAPAPAR
MAV_4796|M.avium_104 GSHAELRPFPGRPSRPTDPGRAVAGEHGFRFFPAYYLHIWDLFQRIPVYE
TH_1483|M.thermoresistible__bu GFHAFFRQYYNLRTLLRR----IDPGLGMLTPVDDYPLVDAHGRRDTFRG
MSMEG_2347|M.smegmatis_MC2_155 DILDDVFAAVGESVGDRLQLLPVDPAYRAQFADGSALEVHSDADRMAAAI
Mflv_4235|M.gilvum_PYR-GCK PLALASPFFAAFDLRARGVTLEVPEVSYGNPLPGRRAAIGYLDIDRTCAE
Mvan_4388|M.vanbaalenii_PYR-1 GSQGNPLTGLAAQAGARTVETNFDDVVVLDGGRAVDPAAVEEVSRDWMGV
.
Mb3754|M.bovis_AF2122/97 RRRP-TFARIIGKVVE---------------PPRQLVRILLRGPMVIVG-
Rv3727|M.tuberculosis_H37Rv RRRP-TFARIIGKVVE---------------PPRQLVRILLRGPMVIVG-
MMAR_2963|M.marinum_M RRRT-TFA-LLARVFE---------------PLAQFSRMVVRSALVIVG-
MAV_4796|M.avium_104 LRNPGGWAPTARTVYDNVRRVITQGVTIDGKPSLVFPRELPRSGAEFLGI
TH_1483|M.thermoresistible__bu LPKT---------------------------PPFNAMAFALRSPTFRLR-
MSMEG_2347|M.smegmatis_MC2_155 ADLA--------------------------GPSEAAGYRRLRDWLTRLYR
Mflv_4235|M.gilvum_PYR-GCK LEDG--------------------------EPWRRLLGPLAADCDGVVG-
Mvan_4388|M.vanbaalenii_PYR-1 LDEIEP------------------------MTADAAPDVSLADGLVWAG-
. .
Mb3754|M.bovis_AF2122/97 ---LAQRGVPATDVLHYLYAHLRLLWMCRER-LLAELGDISYADYLQLGC
Rv3727|M.tuberculosis_H37Rv ---LAQRGVPATDVLHYLYAHLRLLWMCRER-LLAELGDISYADYLQLGC
MMAR_2963|M.marinum_M ---MASRGVSPIDAIRYLHAHVRLLWMCPER-LTAELADVAYEDYLQLGK
MAV_4796|M.avium_104 LGQLATVGLTFGDVATFQGRMLRYLVTSPLR-RARELQNMSAYDFFVGHD
TH_1483|M.thermoresistible__bu ------------DLIRLNARAAAPLAAVELPGIYRHLDDTDAESFLRAIN
MSMEG_2347|M.smegmatis_MC2_155 -----------IEIDGFIGANFDSPLSLLTPQLAQLAAIGGFGKWDHMVR
Mflv_4235|M.gilvum_PYR-GCK -------------LLLGDKRSIPPSIPAALR-VAPRLLAQGTPAWGTLLG
Mvan_4388|M.vanbaalenii_PYR-1 --------------ADLEDPLMQWMVSAAIGAEYAADPEELALRWFGHEG
:
Mb3754|M.bovis_AF2122/97 KSAQAQEFFSAVPRIYVAARTSAEAAAIAPIVLKGLFRLKSNCPSALNDA
Rv3727|M.tuberculosis_H37Rv KSAQAQEFFSAVPRIYVAARTSAEAAAIAPIVLKGLFRLKSNCPSALNDA
MMAR_2963|M.marinum_M KAPRAQAFFSALPRIFVAARPNAEAAAIAPIILKGLFHFTS-RPAALNGI
MAV_4796|M.avium_104 RRTGLNQYSYTPRCDALLRQMPKVLVAFDSRWGDARTNISTYLQLYLNMD
TH_1483|M.thermoresistible__bu FPPAARHLAFEVFSRSFFAQPSQLSAAELATMFH-IYFLGSSEGLVFD--
MSMEG_2347|M.smegmatis_MC2_155 RHLRDPRLQRVFTFQSLYAGVSPQRALAAYAVIAYMDTISG---------
Mflv_4235|M.gilvum_PYR-GCK EDAR---ALFTGVAAHTISRMPSLVASGAGLMLSTLAHAVG---------
Mvan_4388|M.vanbaalenii_PYR-1 EFDGPDLILPGGYRQLIDHLARDLDIRLDAEVTRIAYDDVG---------
Mb3754|M.bovis_AF2122/97 KLP--AIMMMDGPTSERMVDPWIRHLTRLGVDIH--FNTRVGDLEFDDGR
Rv3727|M.tuberculosis_H37Rv KLP--AIMMMDGPTSERMVDPWIRHLTRLGVDIH--FNTRVGDLEFDDGR
MMAR_2963|M.marinum_M TAP--SIMMMNGPTSERMVDPWIRHLQTLGVDLK--FDTRIDDLEFRDGR
MAV_4796|M.avium_104 RRDDKADGVLNGPTTESWFDHWYRHLVALGVRFVRAAATRLDPVPVDPSR
TH_1483|M.thermoresistible__bu --------VVNANFDVALWNPLRDQLESRGVRFH----TGVGVRAVDAGA
MSMEG_2347|M.smegmatis_MC2_155 -------VFFPKGGVRAVPDALAAAGADAGVRFH--YGATVNCLERSADR
Mflv_4235|M.gilvum_PYR-GCK -------WPIPVGGSQAIPDALIADLRAHGGELV------VGEEVSTP--
Mvan_4388|M.vanbaalenii_PYR-1 ------------VTVETAQEVLRADRVIVTVPLG----------------
: :
Mb3754|M.bovis_AF2122/97 VTALIS------SDGRRFACDYALLAVPYLTLRELAKSAHVKRYLPQLT-
Rv3727|M.tuberculosis_H37Rv VTALIS------SDGRRFACDYALLAVPYLTLRELAKSAHVKRYLPQLT-
MMAR_2963|M.marinum_M VTALVS------ADGRRFGCDFAVLALPYLTLRRLAERDCVSRHLPHLT-
MAV_4796|M.avium_104 PPHLRPRVQITLTDGTRVTPDYIVVAVDAPGAEFLTAPMRAAGTGGTVAG
TH_1483|M.thermoresistible__bu RFRVSCD------SGDELTADGVVLATDVTGLQRIVAASPGLGDAGWRD-
MSMEG_2347|M.smegmatis_MC2_155 VTAVHTD------TGERIPCDAVVLTTELPRTYELLGRTPRRPRPWRAS-
Mflv_4235|M.gilvum_PYR-GCK ------------------PSGVVLYDTAPTALLDIYGDRLPSRYARTLR-
Mvan_4388|M.vanbaalenii_PYR-1 ----------------VLKAGVIVFDPPLPQAKRAAVERLGFG-------
. :
Mb3754|M.bovis_AF2122/97 -QQHALALEASNGIQCFLRDLP--------------ATWPPFIRPGVVTT
Rv3727|M.tuberculosis_H37Rv -QQHALALEASNGIQCFLRDLP--------------ATWPPFIRPGVVTT
MMAR_2963|M.marinum_M -QQHAIALESSNGLQFFLRDIP--------------PTWPAHVRPGVVGT
MAV_4796|M.avium_104 LDGFATSVPPPDGPLQPQSTRPRHRRDPYAMDELGRVPWDRFQTLCGIQY
TH_1483|M.thermoresistible__bu ---------------------------------------------RIAGL
MSMEG_2347|M.smegmatis_MC2_155 ---------------------------------------PSAVVVHVGCR
Mflv_4235|M.gilvum_PYR-GCK -------------------------------------------RYRYGPG
Mvan_4388|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3754|M.bovis_AF2122/97 HLQSQWSLVC-------------VLQGEGFWKNVRLP--EGTRYVLSITW
Rv3727|M.tuberculosis_H37Rv HLQSQWSLVC-------------VLQGEGFWKNVRLP--EGTRYVLSITW
MMAR_2963|M.marinum_M HFESEWALVS-------------VLQGEGFWADVALP--AGTKYVLSITW
MAV_4796|M.avium_104 YFDTEFQLLRGHLLYAGTEWALSSINQTGMWERPPILDRDGHVSVLSVDI
TH_1483|M.thermoresistible__bu HTAPPFVVHR-------------------LWLDRPVAP-DRPPFLGTGGW
MSMEG_2347|M.smegmatis_MC2_155 RIDRPVAHHN--------------ILFGDAWHDTFTDIIDDGRLMRDPSL
Mflv_4235|M.gilvum_PYR-GCK VAKVDFVLSG-----------------EIPWRDKRLASAPTLHMGGDRAT
Mvan_4388|M.vanbaalenii_PYR-1 LLDKVVLVFD-----------------EPFWTEAFDIHSDMLGIAGGAQP
*
Mb3754|M.bovis_AF2122/97 SDVETPG------PVFDRPLSECTPDEILTECLTQCGLDKSNVLGWRIDH
Rv3727|M.tuberculosis_H37Rv SDVETPG------PVFDRPLSECTPDEILTECLTQCGLDKSNVLGWRIDH
MMAR_2963|M.marinum_M SDVDTPG------PVFGRPASECTPDEIATECLAQCGLDRSHIAGWHIDD
MAV_4796|M.avium_104 GDFNAASSHLVDESGRGKAARDCTPDEIATEVWRQIVAALTSSTG---PA
TH_1483|M.thermoresistible__bu SPLDNVS-------------VLETYEHQARDWARCTGGSVVELHSYAVTE
MSMEG_2347|M.smegmatis_MC2_155 LVTRPTRG----DPALAPAGRDLLYLLAPTPNLSSTAIDWETEGPAYAQR
Mflv_4235|M.gilvum_PYR-GCK MALAEKD---------IAEGRHAQWPMVLASLPHLADPGRIDAAGRRPLW
Mvan_4388|M.vanbaalenii_PYR-1 VSDLVNG---------------LRFTDVPLLVGLRGGANARAREADSDQQ
Mb3754|M.bovis_AF2122/97 ELKHLDEAEYEKVASELPPHLVSAPARGQRMVNFSPLTVLMPGARHRSPG
Rv3727|M.tuberculosis_H37Rv ELKHLDEAEYEKVASELPPHLVSAPARGQRMVNFSPLTVLMPGARHRSPG
MMAR_2963|M.marinum_M ELKHLSEADYQSLASDLPPHLASAPARGQRMVNLSPLTILLPGARDRSPR
MAV_4796|M.avium_104 GEEFMPRPVWYALDRGLIMESGPGQGRGRAVRNATPYLVPIVGDWDNRPS
TH_1483|M.thermoresistible__bu PTDGLRDALLDRLH-ALYPETADAGIVAERVLCRQDCPRFAPGDHAGRPG
MSMEG_2347|M.smegmatis_MC2_155 VVDTVAERLLPELRDDAQVLQVVTPADWARQGMVAGTPFALAHTFSQTGP
Mflv_4235|M.gilvum_PYR-GCK TYAHVPAGSTVDMAETITG-VFERFAPGFRDLVVGVRSVPAARLADHNAN
Mvan_4388|M.vanbaalenii_PYR-1 TVGEVLAALRAPDPVGVFVTRWAADPYARGSYSFLAVGSSPADQQALAEP
:
Mb3754|M.bovis_AF2122/97 ------------------------ICTSVPNLLLAGEVIYSPDLTLF---
Rv3727|M.tuberculosis_H37Rv ------------------------ICTSVPNLLLAGEVIYSPDLTLF---
MMAR_2963|M.marinum_M ------------------------IRTEVGNLFLAGEASYSPELTFL---
MAV_4796|M.avium_104 SDPWNPHGTSWSSVPPEDWWLEDLWRRNVWQARHGGYQVHNNAVVFAGTW
TH_1483|M.thermoresistible__bu ------------------------VAGPHPALALAGDGIR---IDLP---
MSMEG_2347|M.smegmatis_MC2_155 -------------------------FRPGNTVRGVANAVLAGSSTVPG--
Mflv_4235|M.gilvum_PYR-GCK --------------------------LVGGDIGVGGNNMFSALTGPALR-
Mvan_4388|M.vanbaalenii_PYR-1 ---------------------------VADRVAFAGEATHPEFFATVHG-
.
Mb3754|M.bovis_AF2122/97 ------VPTMEKAACSGYLAARQIMN------------------------
Rv3727|M.tuberculosis_H37Rv ------VPTMEKAACSGYLAARQIMN------------------------
MMAR_2963|M.marinum_M ------VPTMEKAASSGYLAAHNILG------------------------
MAV_4796|M.avium_104 NKTFTRLTSMEAACESGRHAVNAILDHYIWVQSGGLDRREKTMLSWEFPF
TH_1483|M.thermoresistible__bu ------VALMERAATTGWSAANRLLT------------------------
MSMEG_2347|M.smegmatis_MC2_155 -------VGVPTALLSGRLAADRVTG------------------------
Mflv_4235|M.gilvum_PYR-GCK ------WNPWATPIPRTYLCSSATPP------------------------
Mvan_4388|M.vanbaalenii_PYR-1 ------------AYLSGLREADRILR------------------------
.
Mb3754|M.bovis_AF2122/97 --------------MVASHAAP-LRIDFRDPAPFAVLRRVDRWFWSRRRR
Rv3727|M.tuberculosis_H37Rv --------------MVASHAAP-LRIDFRDPAPFAVLRRVDRWFWSRRRR
MMAR_2963|M.marinum_M --------------VGAADAAPELRIDFNDPVPFAGLRRVDRWFWNRRRP
MAV_4796|M.avium_104 GFLDQGLSSPIRMPTPAGDYCYVFDIENREPADTRALRILDSKFCERSLP
TH_1483|M.thermoresistible__bu --------------HFGLAGHPLYTVPTRGRS--AALRRLARREVRQVR-
MSMEG_2347|M.smegmatis_MC2_155 --------------------------TVRRTRTHHDINSVTAATADRKAR
Mflv_4235|M.gilvum_PYR-GCK ------------------------GGGVHGMAGYYAARTVLRREFGIREM
Mvan_4388|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3754|M.bovis_AF2122/97 PP---DRSTFATPPTA----------------------------------
Rv3727|M.tuberculosis_H37Rv PP---DRSTFATPPTA----------------------------------
MMAR_2963|M.marinum_M PESPCDPPGAACPSEN----------------------------------
MAV_4796|M.avium_104 HPLDVGAPTSFIPPPAGGQEMFGPTTDYNQQLLAYLQAWRELLERWTAMC
TH_1483|M.thermoresistible__bu --------------------------------------------------
MSMEG_2347|M.smegmatis_MC2_155 MP------------------------------------------------
Mflv_4235|M.gilvum_PYR-GCK PPLAP---------------------------------------------
Mvan_4388|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3754|M.bovis_AF2122/97 --------------MPAPSHLTDVDRSAS---------------------
Rv3727|M.tuberculosis_H37Rv --------------MPAPSHLTDVDRSAS---------------------
MMAR_2963|M.marinum_M --------------GVPHGCPTPVPHPESAPRR-----------------
MAV_4796|M.avium_104 AATPSPAAPFTPPFMPPAAAPAPMPPAPADYSQQLFGYLQAWRQYLEQMA
TH_1483|M.thermoresistible__bu --------------------------------------------------
MSMEG_2347|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4235|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4388|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3754|M.bovis_AF2122/97 --------------------------------------------------
Rv3727|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2963|M.marinum_M --------------------------------------------------
MAV_4796|M.avium_104 GASSGSAQQPTAPTTMPPTMPPPTPPTAPPPSMPSTGGQAFGAAPPGQPG
TH_1483|M.thermoresistible__bu --------------------------------------------------
MSMEG_2347|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4235|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4388|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3754|M.bovis_AF2122/97 --------------------------------------------------
Rv3727|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2963|M.marinum_M --------------------------------------------------
MAV_4796|M.avium_104 TSGDPTPGGSTPVSATAKGSTLTWPPPLLGLEPSSYVGTQDPPVSRFLPP
TH_1483|M.thermoresistible__bu --------------------------------------------------
MSMEG_2347|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4235|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4388|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3754|M.bovis_AF2122/97 --------------------------------------------------
Rv3727|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2963|M.marinum_M --------------------------------------------------
MAV_4796|M.avium_104 NLVNRVEDRREVLLRPNDEYGYLHDLFSLNPGLARAISSTGPAPVASGSS
TH_1483|M.thermoresistible__bu --------------------------------------------------
MSMEG_2347|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4235|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4388|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3754|M.bovis_AF2122/97 ------------------------------------------
Rv3727|M.tuberculosis_H37Rv ------------------------------------------
MMAR_2963|M.marinum_M ------------------------------------------
MAV_4796|M.avium_104 FLGAMNRVGPDVSARVTPRSLFSSRAARAPSAGAITPGSRTG
TH_1483|M.thermoresistible__bu ------------------------------------------
MSMEG_2347|M.smegmatis_MC2_155 ------------------------------------------
Mflv_4235|M.gilvum_PYR-GCK ------------------------------------------
Mvan_4388|M.vanbaalenii_PYR-1 ------------------------------------------