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M. tuberculosis H37Rv Rv3582c (ispD)

annotation: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
coordinates: 4024344 - 4025039
length: 231

VREAGEVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLDSGVVDTVVVAVPADRTDEARQILG
HRAMIVAGGSNRTDTVNLALTVLSGTAEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVLPLSDT
IKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSLDLPAAEYTDDASLVEHIGGQVQVVDGDP
LAFKITTKLDLLLAQAIVRG*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv3582c ispD - 100% (231) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3613c ispD 1e-124 99.57% (231) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
M. gilvum PYR-GCK Mflv_2529 - 3e-15 31.20% (234) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
M. leprae Br4923 MLBr_00321 ispD 3e-80 66.95% (236) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
M. abscessus ATCC 19977 MAB_0569 - 3e-55 52.38% (210) putative 2-C-methyl-D-erythritol 4-phosphate
M. marinum M MMAR_5082 ispD 2e-91 76.34% (224) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD
M. avium 104 MAV_0571 ispD 2e-86 72.12% (226) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
M. smegmatis MC2 155 MSMEG_6076 ispD 4e-69 62.61% (222) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
M. thermoresistible (build 8) TH_2770 - 5e-28 37.33% (225) PUTATIVE putative 4-diphosphocytidyl-2C-methyl-D-erythritol
M. ulcerans Agy99 MUL_4158 ispD 7e-91 75.45% (224) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
M. vanbaalenii PYR-1 Mvan_4130 - 8e-17 30.60% (232) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase

CLUSTAL 2.0.9 multiple sequence alignment


Rv3582c|M.tuberculosis_H37Rv        MVREAG---EVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLD
Mb3613c|M.bovis_AF2122/97           MVREAG---EVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLD
MMAR_5082|M.marinum_M               MAGGTQ---GVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLLE
MUL_4158|M.ulcerans_Agy99           MAGGTQ---GVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLFE
MLBr_00321|M.leprae_Br4923          MAVATG---TVVAVVPAAGAGKRLAAGIPKAFCELDGRTLVERAVVGLLE
MAV_0571|M.avium_104                MAPETGSSGAVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLD
MSMEG_6076|M.smegmatis_MC2_155      MA--------TVAVVPAAGSGERLRAGRPKAFVTLGGTPLLEHALSGLRA
MAB_0569|M.abscessus_ATCC_1997      ---------------------MRLGANTPKAFVSVGGRTMLQRCVDGLLA
TH_2770|M.thermoresistible__bu      -----------MTYAAIVPLAATVP--RTDVFTPLAGMPALVRAVRMLAE
Mvan_4130|M.vanbaalenii_PYR-1       -----------MTVTAILPVPESYVQRREAVFAPVAGESPLVRIVRALAA
Mflv_2529|M.gilvum_PYR-GCK          --------MDAVGVVLAAGLGTRVGADGNKAYLPLAGRSMLAWSLDTLTR
                                                                  .:  : * . :   :  *  

Rv3582c|M.tuberculosis_H37Rv        SGVVDTVVVAVPADRTDEARQILGH--------RAMIVAGG---SNRTDT
Mb3613c|M.bovis_AF2122/97           SGVVDTVVVAVPADRTDEARQILGH--------RAMIVAGG---SNRTDT
MMAR_5082|M.marinum_M               SGVVDTVVVAVPPDRTDEAKLILGR--------EATIVAGG---ADRTES
MUL_4158|M.ulcerans_Agy99           SGVVDTVVVAVPPDRTDEAKLILGR--------EATIVAGG---ADRTES
MLBr_00321|M.leprae_Br4923          SGVVDHVVVAVPADRIAQTQWVLSQRLANSAGQHATVVAGG---ADRTKS
MAV_0571|M.avium_104                SKVVDHVVVAVPADRVDEAKRLLAA--------QATVVAGG---ADRTAS
MSMEG_6076|M.smegmatis_MC2_155      SGVIDRIVIAVPPALTDESKLVFGG-------EDSVIVSGG---VDRTES
MAB_0569|M.abscessus_ATCC_1997      SGAVDEVVVVVGADQLERAAALVGS--------GATVVQGG---AERTDS
TH_2770|M.thermoresistible__bu      EAGADVVLVAVAAALADEARAALSG-----VAGTEVVSVDG--AGRRLDC
Mvan_4130|M.vanbaalenii_PYR-1       VG---DVVVAAAQSLADEVRETLAA-----QALPAVRTVGARSPGARADC
Mflv_2529|M.gilvum_PYR-GCK          LPDVARTILVFRRGEFALAHDTVRHELG---DRPIEFVEGG---ETRHGS
                                           ::.            .                ..     *   

Rv3582c|M.tuberculosis_H37Rv        VNLALTVLSGT---AEPEFVLVHDAARALTPPALVARVVEALRDGYAAVV
Mb3613c|M.bovis_AF2122/97           VNLALAVLSGT---AEPEFVLVHDAARALTPPALVARVVEALRDGYAAVV
MMAR_5082|M.marinum_M               VSRALSALSAG---VSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVV
MUL_4158|M.ulcerans_Agy99           VSRALSALSAG---VSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVV
MLBr_00321|M.leprae_Br4923          VCQALATLPAPSRVGAPEFILVHDAARALTPARLIVRVVDALRAGHTAVV
MAV_0571|M.avium_104                VRLALAAVP-----GNPAFVLVHDAARALTPPALIARVVQALRDGHRAVV
MSMEG_6076|M.smegmatis_MC2_155      VALALEAAG------DAEFVLVHDAARALTPPALIARVVAALKEGHSAVV
MAB_0569|M.abscessus_ATCC_1997      VRAGLAAVD------AADWILVHDAARPLTPPDMIARIVAELRTGRGAVI
TH_2770|M.thermoresistible__bu      LHAGLDAVRNR--STPPHHVLVHDCRRPLTPPAVVRRVRAALADGAEAVI
Mvan_4130|M.vanbaalenii_PYR-1       IAAGLAALGDG--DGP---VLLHDLTWPLIADATLDAVLSAVHGGADAVL
Mflv_2529|M.gilvum_PYR-GCK          ETNMLRHLADDIDAGTVDVVAIHDAARPLAGPEMFGRAIALARQ-YGGAL
                                        *              : :**   .*     .            ..:

Rv3582c|M.tuberculosis_H37Rv        PVLPLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSL
Mb3613c|M.bovis_AF2122/97           PVLPLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSL
MMAR_5082|M.marinum_M               PVLPLTDTIKAVDANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAG-
MUL_4158|M.ulcerans_Agy99           PVLPLTDTIKAVDANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAG-
MLBr_00321|M.leprae_Br4923          PALPLSDTIKAVDANGMVLGTPARVGLRAVQTPQGFATELLWCAYQRGP-
MAV_0571|M.avium_104                PALPLHDTVKAVDANGVVLGTPERDGLRAVQTPQGFATDLLLRAYAAG--
MSMEG_6076|M.smegmatis_MC2_155      PGLAPADTIKAVDANGAVLGTPERAGLRAVQTPQGFHADVLRRAYARAT-
MAB_0569|M.abscessus_ATCC_1997      PAVAVADTIKSIDVHGDVIGTPDRAGLRAVQTPQGFAADVLRRAYAAAG-
TH_2770|M.thermoresistible__bu      PALPFTDSAKTVDASGSITATLDRATLRTAQHPRGFPVDRLAQLLDGAD-
Mvan_4130|M.vanbaalenii_PYR-1       PIRPVTDSVKAVDARGAVTATLDRSPLRTVQFPRGFDAAVLERLLADGA-
Mflv_2529|M.gilvum_PYR-GCK          PALPTRDLAEMRDD--ILQPVARRGELVRVQTPQAFRARDLLHAYRCAE-
                                    *  .  *  :  *    :  .  *  *  .* *:.* .  *      .  

Rv3582c|M.tuberculosis_H37Rv        DLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG--
Mb3613c|M.bovis_AF2122/97           DLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG--
MMAR_5082|M.marinum_M               ---VAAFTDDASLVEHVGGQVHVVAGDPLAFKITNRLDLLLAHAVVRG--
MUL_4158|M.ulcerans_Agy99           ---VSAFTDDASLVEHVGGQVHVVGGDPLAFKITNRLDLLLAHAVVRG--
MLBr_00321|M.leprae_Br4923          HLDAVDFTDDASLVEHLGGQVQVVAGDPLAFKITTQLDLLLAKKILRR--
MAV_0571|M.avium_104                -AGTAGFTDDASLVEHVGGQVQVVDGDPLAFKITTQLDLLLAETIVRR--
MSMEG_6076|M.smegmatis_MC2_155      ---AGGVTDDASLVEQLGTPVQIVDGDPLAFKITTPLDLVLAEAVLARGA
MAB_0569|M.abscessus_ATCC_1997      ----DIATDDAALVEQIGERVHVVEGDRLAFKITTTLDMTLAEAILGATE
TH_2770|M.thermoresistible__bu      -----SAADELLEAQRVGLTLTLVDGDPDGFVVRLPDAASLVEAVITARA
Mvan_4130|M.vanbaalenii_PYR-1       -----ADFDELGAALSVGTPLTLVEGDTDTMSFDLPADSAFLAAVIAGR-
Mflv_2529|M.gilvum_PYR-GCK          RDGFEGTDTSSCVERYTDVQVRIFDGRATNLKVTYARDVAVAQHLLNPPG
                                             .       .  : :. *    : .       .   ::    

Rv3582c|M.tuberculosis_H37Rv        -----
Mb3613c|M.bovis_AF2122/97           -----
MMAR_5082|M.marinum_M               -----
MUL_4158|M.ulcerans_Agy99           -----
MLBr_00321|M.leprae_Br4923          -----
MAV_0571|M.avium_104                -----
MSMEG_6076|M.smegmatis_MC2_155      -----
MAB_0569|M.abscessus_ATCC_1997      GVQ--
TH_2770|M.thermoresistible__bu      GRI--
Mvan_4130|M.vanbaalenii_PYR-1       -----
Mflv_2529|M.gilvum_PYR-GCK          QSPGS

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv3582c	ispD	-	100% (231)	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase