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M. avium 104 MAV_0571 (ispD)

annotation: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
coordinates: 553445 - 554134
length: 229

LAPETGSSGAVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLDSKVVDHVVVAVPADRVDEAK
RLLAAQATVVAGGADRTASVRLALAAVPGNPAFVLVHDAARALTPPALIARVVQALRDGHRAVVPALPLH
DTVKAVDANGVVLGTPERDGLRAVQTPQGFATDLLLRAYAAGAGTAGFTDDASLVEHVGGQVQVVDGDPL
AFKITTQLDLLLAETIVRR

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. avium 104 MAV_0571 ispD - 100% (229) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3613c ispD 6e-87 72.57% (226) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
M. gilvum PYR-GCK Mflv_2528 - 4e-16 31.25% (224) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
M. tuberculosis H37Rv Rv3582c ispD 2e-86 72.12% (226) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
M. leprae Br4923 MLBr_00321 ispD 3e-82 68.91% (238) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
M. abscessus ATCC 19977 MAB_0569 - 5e-58 58.54% (205) putative 2-C-methyl-D-erythritol 4-phosphate
M. marinum M MMAR_5082 ispD 9e-84 71.56% (225) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD
M. smegmatis MC2 155 MSMEG_6076 ispD 8e-70 64.25% (221) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
M. thermoresistible (build 8) TH_2770 - 1e-26 38.22% (225) PUTATIVE putative 4-diphosphocytidyl-2C-methyl-D-erythritol
M. ulcerans Agy99 MUL_4158 ispD 3e-83 70.67% (225) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
M. vanbaalenii PYR-1 Mvan_4130 - 5e-18 36.27% (204) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase

CLUSTAL 2.0.9 multiple sequence alignment


Mb3613c|M.bovis_AF2122/97           MVREAG---EVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLD
Rv3582c|M.tuberculosis_H37Rv        MVREAG---EVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLD
MMAR_5082|M.marinum_M               MAGGTQ---GVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLLE
MUL_4158|M.ulcerans_Agy99           MAGGTQ---GVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLFE
MAV_0571|M.avium_104                MAPETGSSGAVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLD
MLBr_00321|M.leprae_Br4923          MAVATG---TVVAVVPAAGAGKRLAAGIPKAFCELDGRTLVERAVVGLLE
MSMEG_6076|M.smegmatis_MC2_155      MA--------TVAVVPAAGSGERLRAGRPKAFVTLGGTPLLEHALSGLRA
MAB_0569|M.abscessus_ATCC_1997      ---------------------MRLGANTPKAFVSVGGRTMLQRCVDGLLA
Mflv_2528|M.gilvum_PYR-GCK          -----------MTITALLPVPADLARQPETVFAPVAGQSSLERIVRSLAA
Mvan_4130|M.vanbaalenii_PYR-1       -----------MTVTAILPVPESYVQRREAVFAPVAGESPLVRIVRALAA
TH_2770|M.thermoresistible__bu      -----------MTYAAIVPLAATVPR--TDVFTPLAGMPALVRAVRMLAE
                                                                  .*  : * . : : :  *  

Mb3613c|M.bovis_AF2122/97           SGVVDTVVVAVPADRTDEARQILGH--------RAMIVAGGSNRTDTVNL
Rv3582c|M.tuberculosis_H37Rv        SGVVDTVVVAVPADRTDEARQILGH--------RAMIVAGGSNRTDTVNL
MMAR_5082|M.marinum_M               SGVVDTVVVAVPPDRTDEAKLILGR--------EATIVAGGADRTESVSR
MUL_4158|M.ulcerans_Agy99           SGVVDTVVVAVPPDRTDEAKLILGR--------EATIVAGGADRTESVSR
MAV_0571|M.avium_104                SKVVDHVVVAVPADRVDEAKRLLAA--------QATVVAGGADRTASVRL
MLBr_00321|M.leprae_Br4923          SGVVDHVVVAVPADRIAQTQWVLSQRLANSAGQHATVVAGGADRTKSVCQ
MSMEG_6076|M.smegmatis_MC2_155      SGVIDRIVIAVPPALTDESKLVFGG-------EDSVIVSGGVDRTESVAL
MAB_0569|M.abscessus_ATCC_1997      SGAVDEVVVVVGADQLERAAALVGS--------GATVVQGGAERTDSVRA
Mflv_2528|M.gilvum_PYR-GCK          VC---DVVVAVAEEMSDDVAAVLSAP--DVQAVRLTVAAAPGRRRECLAA
Mvan_4130|M.vanbaalenii_PYR-1       VG---DVVVAAAQSLADEVRETLAAQ--ALPAVRTVGARSPGARADCIAA
TH_2770|M.thermoresistible__bu      EAGADVVLVAVAAALADEARAALSG----VAGTEVVSVDGAGRRLDCLHA
                                          :::..           ..             . .   *   :  

Mb3613c|M.bovis_AF2122/97           ALAVLSGT---AEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVL
Rv3582c|M.tuberculosis_H37Rv        ALTVLSGT---AEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVL
MMAR_5082|M.marinum_M               ALSALSAG---VSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVVPVL
MUL_4158|M.ulcerans_Agy99           ALSALSAG---VSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVVPVL
MAV_0571|M.avium_104                ALAAVP-----GNPAFVLVHDAARALTPPALIARVVQALRDGHRAVVPAL
MLBr_00321|M.leprae_Br4923          ALATLPAPSRVGAPEFILVHDAARALTPARLIVRVVDALRAGHTAVVPAL
MSMEG_6076|M.smegmatis_MC2_155      ALEAAG------DAEFVLVHDAARALTPPALIARVVAALKEGHSAVVPGL
MAB_0569|M.abscessus_ATCC_1997      GLAAVD------AADWILVHDAARPLTPPDMIARIVAELRTGRGAVIPAV
Mflv_2528|M.gilvum_PYR-GCK          GLAGLHDG-------PVLVHDIGWPIFSQQTLEGVLGALHRGADAVLPIC
Mvan_4130|M.vanbaalenii_PYR-1       GLAALGDGD--G---PVLLHDLTWPLIADATLDAVLSAVHGGADAVLPIR
TH_2770|M.thermoresistible__bu      GLDAVRNRS--TPPHHVLVHDCRRPLTPPAVVRRVRAALADGAEAVIPAL
                                    .*              :*:**   .: .   :  :   :  *  **:*  

Mb3613c|M.bovis_AF2122/97           PLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSLDLP
Rv3582c|M.tuberculosis_H37Rv        PLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSLDLP
MMAR_5082|M.marinum_M               PLTDTIKAVDANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAG----
MUL_4158|M.ulcerans_Agy99           PLTDTIKAVDANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAG----
MAV_0571|M.avium_104                PLHDTVKAVDANGVVLGTPERDGLRAVQTPQGFATDLLLRAYAAG---AG
MLBr_00321|M.leprae_Br4923          PLSDTIKAVDANGMVLGTPARVGLRAVQTPQGFATELLWCAYQRGP-HLD
MSMEG_6076|M.smegmatis_MC2_155      APADTIKAVDANGAVLGTPERAGLRAVQTPQGFHADVLRRAYARAT----
MAB_0569|M.abscessus_ATCC_1997      AVADTIKSIDVHGDVIGTPDRAGLRAVQTPQGFAADVLRRAYAAAG----
Mflv_2528|M.gilvum_PYR-GCK          AVTDSIKAVDGRGVITATVDRAPLRTVQYPRGFSAAMLAQLIGTSD----
Mvan_4130|M.vanbaalenii_PYR-1       PVTDSVKAVDARGAVTATLDRSPLRTVQFPRGFDAAVLERLLADGA----
TH_2770|M.thermoresistible__bu      PFTDSAKTVDASGSITATLDRATLRTAQHPRGFPVDRLAQLLDGAD----
                                    .  *: *::*  * : .*  *  **:.* *:** .  *      .     

Mb3613c|M.bovis_AF2122/97           AAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG-----
Rv3582c|M.tuberculosis_H37Rv        AAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG-----
MMAR_5082|M.marinum_M               VAAFTDDASLVEHVGGQVHVVAGDPLAFKITNRLDLLLAHAVVRG-----
MUL_4158|M.ulcerans_Agy99           VSAFTDDASLVEHVGGQVHVVGGDPLAFKITNRLDLLLAHAVVRG-----
MAV_0571|M.avium_104                TAGFTDDASLVEHVGGQVQVVDGDPLAFKITTQLDLLLAETIVRR-----
MLBr_00321|M.leprae_Br4923          AVDFTDDASLVEHLGGQVQVVAGDPLAFKITTQLDLLLAKKILRR-----
MSMEG_6076|M.smegmatis_MC2_155      AGGVTDDASLVEQLGTPVQIVDGDPLAFKITTPLDLVLAEAVLARGA---
MAB_0569|M.abscessus_ATCC_1997      -DIATDDAALVEQIGERVHVVEGDRLAFKITTTLDMTLAEAILGATEGVQ
Mflv_2528|M.gilvum_PYR-GCK          --FDDDELETVLTGGDGTVLIDGDTAISRIELPCDAAYLDALLTSRDSDP
Mvan_4130|M.vanbaalenii_PYR-1       --ADFDELGAALSVGTPLTLVEGDTDTMSFDLPADSAFLAAVIAGR----
TH_2770|M.thermoresistible__bu      --SAADELLEAQRVGLTLTLVDGDPDGFVVRLPDAASLVEAVITARAGRI
                                         *:   .   *    :: **     .           ::       

Mb3613c|M.bovis_AF2122/97           --
Rv3582c|M.tuberculosis_H37Rv        --
MMAR_5082|M.marinum_M               --
MUL_4158|M.ulcerans_Agy99           --
MAV_0571|M.avium_104                --
MLBr_00321|M.leprae_Br4923          --
MSMEG_6076|M.smegmatis_MC2_155      --
MAB_0569|M.abscessus_ATCC_1997      --
Mflv_2528|M.gilvum_PYR-GCK          AG
Mvan_4130|M.vanbaalenii_PYR-1       --
TH_2770|M.thermoresistible__bu      --

species	id	gene	e-value	identity (len)	annotation
M. avium 104	MAV_0571	ispD	-	100% (229)	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase