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VVREAGEVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLDSGVVDTVVVAVPADRTDEARQIL GHRAMIVAGGSNRTDTVNLALAVLSGTAEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVLPLSD TIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSLDLPAAEYTDDASLVEHIGGQVQVVDGD PLAFKITTKLDLLLAQAIVRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3613c | ispD | - | 100% (231) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2529 | - | 4e-15 | 31.20% (234) | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase |
| M. tuberculosis H37Rv | Rv3582c | ispD | 1e-124 | 99.57% (231) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. leprae Br4923 | MLBr_00321 | ispD | 1e-80 | 67.37% (236) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. abscessus ATCC 19977 | MAB_0569 | - | 1e-55 | 52.86% (210) | putative 2-C-methyl-D-erythritol 4-phosphate |
| M. marinum M | MMAR_5082 | ispD | 2e-91 | 76.34% (224) | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD |
| M. avium 104 | MAV_0571 | ispD | 7e-87 | 72.57% (226) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. smegmatis MC2 155 | MSMEG_6076 | ispD | 4e-69 | 62.61% (222) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. thermoresistible (build 8) | TH_2770 | - | 2e-28 | 37.78% (225) | PUTATIVE putative 4-diphosphocytidyl-2C-methyl-D-erythritol |
| M. ulcerans Agy99 | MUL_4158 | ispD | 7e-91 | 75.45% (224) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4130 | - | 3e-17 | 31.03% (232) | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3613c|M.bovis_AF2122/97 MVREAG---EVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLD
Rv3582c|M.tuberculosis_H37Rv MVREAG---EVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLD
MMAR_5082|M.marinum_M MAGGTQ---GVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLLE
MUL_4158|M.ulcerans_Agy99 MAGGTQ---GVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLFE
MLBr_00321|M.leprae_Br4923 MAVATG---TVVAVVPAAGAGKRLAAGIPKAFCELDGRTLVERAVVGLLE
MAV_0571|M.avium_104 MAPETGSSGAVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLD
MSMEG_6076|M.smegmatis_MC2_155 MA--------TVAVVPAAGSGERLRAGRPKAFVTLGGTPLLEHALSGLRA
MAB_0569|M.abscessus_ATCC_1997 ---------------------MRLGANTPKAFVSVGGRTMLQRCVDGLLA
TH_2770|M.thermoresistible__bu -----------MTYAAIVPLAATVP--RTDVFTPLAGMPALVRAVRMLAE
Mvan_4130|M.vanbaalenii_PYR-1 -----------MTVTAILPVPESYVQRREAVFAPVAGESPLVRIVRALAA
Mflv_2529|M.gilvum_PYR-GCK --------MDAVGVVLAAGLGTRVGADGNKAYLPLAGRSMLAWSLDTLTR
.: : * . : : *
Mb3613c|M.bovis_AF2122/97 SGVVDTVVVAVPADRTDEARQILGH--------RAMIVAGG---SNRTDT
Rv3582c|M.tuberculosis_H37Rv SGVVDTVVVAVPADRTDEARQILGH--------RAMIVAGG---SNRTDT
MMAR_5082|M.marinum_M SGVVDTVVVAVPPDRTDEAKLILGR--------EATIVAGG---ADRTES
MUL_4158|M.ulcerans_Agy99 SGVVDTVVVAVPPDRTDEAKLILGR--------EATIVAGG---ADRTES
MLBr_00321|M.leprae_Br4923 SGVVDHVVVAVPADRIAQTQWVLSQRLANSAGQHATVVAGG---ADRTKS
MAV_0571|M.avium_104 SKVVDHVVVAVPADRVDEAKRLLAA--------QATVVAGG---ADRTAS
MSMEG_6076|M.smegmatis_MC2_155 SGVIDRIVIAVPPALTDESKLVFGG-------EDSVIVSGG---VDRTES
MAB_0569|M.abscessus_ATCC_1997 SGAVDEVVVVVGADQLERAAALVGS--------GATVVQGG---AERTDS
TH_2770|M.thermoresistible__bu EAGADVVLVAVAAALADEARAALSG-----VAGTEVVSVDG--AGRRLDC
Mvan_4130|M.vanbaalenii_PYR-1 VG---DVVVAAAQSLADEVRETLAA-----QALPAVRTVGARSPGARADC
Mflv_2529|M.gilvum_PYR-GCK LPDVARTILVFRRGEFALAHDTVRHELG---DRPIEFVEGG---ETRHGS
::. . .. *
Mb3613c|M.bovis_AF2122/97 VNLALAVLSGT---AEPEFVLVHDAARALTPPALVARVVEALRDGYAAVV
Rv3582c|M.tuberculosis_H37Rv VNLALTVLSGT---AEPEFVLVHDAARALTPPALVARVVEALRDGYAAVV
MMAR_5082|M.marinum_M VSRALSALSAG---VSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVV
MUL_4158|M.ulcerans_Agy99 VSRALSALSAG---VSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVV
MLBr_00321|M.leprae_Br4923 VCQALATLPAPSRVGAPEFILVHDAARALTPARLIVRVVDALRAGHTAVV
MAV_0571|M.avium_104 VRLALAAVP-----GNPAFVLVHDAARALTPPALIARVVQALRDGHRAVV
MSMEG_6076|M.smegmatis_MC2_155 VALALEAAG------DAEFVLVHDAARALTPPALIARVVAALKEGHSAVV
MAB_0569|M.abscessus_ATCC_1997 VRAGLAAVD------AADWILVHDAARPLTPPDMIARIVAELRTGRGAVI
TH_2770|M.thermoresistible__bu LHAGLDAVRNR--STPPHHVLVHDCRRPLTPPAVVRRVRAALADGAEAVI
Mvan_4130|M.vanbaalenii_PYR-1 IAAGLAALGDG--DGP---VLLHDLTWPLIADATLDAVLSAVHGGADAVL
Mflv_2529|M.gilvum_PYR-GCK ETNMLRHLADDIDAGTVDVVAIHDAARPLAGPEMFGRAIALARQ-YGGAL
* : :** .* . ..:
Mb3613c|M.bovis_AF2122/97 PVLPLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSL
Rv3582c|M.tuberculosis_H37Rv PVLPLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSL
MMAR_5082|M.marinum_M PVLPLTDTIKAVDANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAG-
MUL_4158|M.ulcerans_Agy99 PVLPLTDTIKAVDANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAG-
MLBr_00321|M.leprae_Br4923 PALPLSDTIKAVDANGMVLGTPARVGLRAVQTPQGFATELLWCAYQRGP-
MAV_0571|M.avium_104 PALPLHDTVKAVDANGVVLGTPERDGLRAVQTPQGFATDLLLRAYAAG--
MSMEG_6076|M.smegmatis_MC2_155 PGLAPADTIKAVDANGAVLGTPERAGLRAVQTPQGFHADVLRRAYARAT-
MAB_0569|M.abscessus_ATCC_1997 PAVAVADTIKSIDVHGDVIGTPDRAGLRAVQTPQGFAADVLRRAYAAAG-
TH_2770|M.thermoresistible__bu PALPFTDSAKTVDASGSITATLDRATLRTAQHPRGFPVDRLAQLLDGAD-
Mvan_4130|M.vanbaalenii_PYR-1 PIRPVTDSVKAVDARGAVTATLDRSPLRTVQFPRGFDAAVLERLLADGA-
Mflv_2529|M.gilvum_PYR-GCK PALPTRDLAEMRDD--ILQPVARRGELVRVQTPQAFRARDLLHAYRCAE-
* . * : * : . * * .* *:.* . * .
Mb3613c|M.bovis_AF2122/97 DLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG--
Rv3582c|M.tuberculosis_H37Rv DLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG--
MMAR_5082|M.marinum_M ---VAAFTDDASLVEHVGGQVHVVAGDPLAFKITNRLDLLLAHAVVRG--
MUL_4158|M.ulcerans_Agy99 ---VSAFTDDASLVEHVGGQVHVVGGDPLAFKITNRLDLLLAHAVVRG--
MLBr_00321|M.leprae_Br4923 HLDAVDFTDDASLVEHLGGQVQVVAGDPLAFKITTQLDLLLAKKILRR--
MAV_0571|M.avium_104 -AGTAGFTDDASLVEHVGGQVQVVDGDPLAFKITTQLDLLLAETIVRR--
MSMEG_6076|M.smegmatis_MC2_155 ---AGGVTDDASLVEQLGTPVQIVDGDPLAFKITTPLDLVLAEAVLARGA
MAB_0569|M.abscessus_ATCC_1997 ----DIATDDAALVEQIGERVHVVEGDRLAFKITTTLDMTLAEAILGATE
TH_2770|M.thermoresistible__bu -----SAADELLEAQRVGLTLTLVDGDPDGFVVRLPDAASLVEAVITARA
Mvan_4130|M.vanbaalenii_PYR-1 -----ADFDELGAALSVGTPLTLVEGDTDTMSFDLPADSAFLAAVIAGR-
Mflv_2529|M.gilvum_PYR-GCK RDGFEGTDTSSCVERYTDVQVRIFDGRATNLKVTYARDVAVAQHLLNPPG
. . : :. * : . . ::
Mb3613c|M.bovis_AF2122/97 -----
Rv3582c|M.tuberculosis_H37Rv -----
MMAR_5082|M.marinum_M -----
MUL_4158|M.ulcerans_Agy99 -----
MLBr_00321|M.leprae_Br4923 -----
MAV_0571|M.avium_104 -----
MSMEG_6076|M.smegmatis_MC2_155 -----
MAB_0569|M.abscessus_ATCC_1997 GVQ--
TH_2770|M.thermoresistible__bu GRI--
Mvan_4130|M.vanbaalenii_PYR-1 -----
Mflv_2529|M.gilvum_PYR-GCK QSPGS