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MAVATGTVVAVVPAAGAGKRLAAGIPKAFCELDGRTLVERAVVGLLESGVVDHVVVAVPADRIAQTQWVL SQRLANSAGQHATVVAGGADRTKSVCQALATLPAPSRVGAPEFILVHDAARALTPARLIVRVVDALRAGH TAVVPALPLSDTIKAVDANGMVLGTPARVGLRAVQTPQGFATELLWCAYQRGPHLDAVDFTDDASLVEHL GGQVQVVAGDPLAFKITTQLDLLLAKKILRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00321 | ispD | - | 100% (241) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3613c | ispD | 3e-80 | 67.37% (236) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. gilvum PYR-GCK | Mflv_2529 | - | 8e-13 | 30.04% (233) | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase |
| M. tuberculosis H37Rv | Rv3582c | ispD | 8e-80 | 66.95% (236) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. abscessus ATCC 19977 | MAB_0569 | - | 2e-51 | 52.73% (220) | putative 2-C-methyl-D-erythritol 4-phosphate |
| M. marinum M | MMAR_5082 | ispD | 8e-81 | 67.92% (240) | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD |
| M. avium 104 | MAV_0571 | ispD | 1e-81 | 68.91% (238) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. smegmatis MC2 155 | MSMEG_6076 | ispD | 9e-62 | 57.51% (233) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. thermoresistible (build 8) | TH_2770 | - | 1e-19 | 34.53% (223) | PUTATIVE putative 4-diphosphocytidyl-2C-methyl-D-erythritol |
| M. ulcerans Agy99 | MUL_4158 | ispD | 8e-80 | 67.08% (240) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4129 | - | 5e-11 | 26.72% (232) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3613c|M.bovis_AF2122/97 MVREAG---EVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLD
Rv3582c|M.tuberculosis_H37Rv MVREAG---EVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLD
MMAR_5082|M.marinum_M MAGGTQ---GVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLLE
MUL_4158|M.ulcerans_Agy99 MAGGTQ---GVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLFE
MLBr_00321|M.leprae_Br4923 MAVATG---TVVAVVPAAGAGKRLAAGIPKAFCELDGRTLVERAVVGLLE
MAV_0571|M.avium_104 MAPETGSSGAVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLD
MSMEG_6076|M.smegmatis_MC2_155 MA--------TVAVVPAAGSGERLRAGRPKAFVTLGGTPLLEHALSGLRA
MAB_0569|M.abscessus_ATCC_1997 ---------------------MRLGANTPKAFVSVGGRTMLQRCVDGLLA
TH_2770|M.thermoresistible__bu -------------MTYAAIVPLAATVPRTDVFTPLAGMPALVRAVRMLAE
Mflv_2529|M.gilvum_PYR-GCK --------MDAVGVVLAAGLGTRVGADGNKAYLPLAGRSMLAWSLDTLTR
Mvan_4129|M.vanbaalenii_PYR-1 --------MDAVGVVLAAGLGTRVGADGNKAYLPLAGRSMLAWSLDTLTR
. ..: : * . : .: *
Mb3613c|M.bovis_AF2122/97 SGVVDTVVVAVPADRTDEARQILGH--------RAMIVAGGSNRTDTVNL
Rv3582c|M.tuberculosis_H37Rv SGVVDTVVVAVPADRTDEARQILGH--------RAMIVAGGSNRTDTVNL
MMAR_5082|M.marinum_M SGVVDTVVVAVPPDRTDEAKLILGR--------EATIVAGGADRTESVSR
MUL_4158|M.ulcerans_Agy99 SGVVDTVVVAVPPDRTDEAKLILGR--------EATIVAGGADRTESVSR
MLBr_00321|M.leprae_Br4923 SGVVDHVVVAVPADRIAQTQWVLSQRLANSAGQHATVVAGGADRTKSVCQ
MAV_0571|M.avium_104 SKVVDHVVVAVPADRVDEAKRLLAA--------QATVVAGGADRTASVRL
MSMEG_6076|M.smegmatis_MC2_155 SGVIDRIVIAVPPALTDESKLVFGG-------EDSVIVSGGVDRTESVAL
MAB_0569|M.abscessus_ATCC_1997 SGAVDEVVVVVGADQLERAAALVGS--------GATVVQGGAERTDSVRA
TH_2770|M.thermoresistible__bu EAGADVVLVAVAAALADEARAALSG----VAGTEVVSVDGAGRRLDCLHA
Mflv_2529|M.gilvum_PYR-GCK LPDVARTILVFRRGEFALAHDTVRHELG---DRPIEFVEGGETRHGSETN
Mvan_4129|M.vanbaalenii_PYR-1 LPDIARTILVYRRGEATLARDTVQSELD---SDAVEFVEGGDTRHGSETN
::. : . * *. *
Mb3613c|M.bovis_AF2122/97 ALAVLSGT---AEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVL
Rv3582c|M.tuberculosis_H37Rv ALTVLSGT---AEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVL
MMAR_5082|M.marinum_M ALSALSAG---VSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVVPVL
MUL_4158|M.ulcerans_Agy99 ALSALSAG---VSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVVPVL
MLBr_00321|M.leprae_Br4923 ALATLPAPSRVGAPEFILVHDAARALTPARLIVRVVDALRAGHTAVVPAL
MAV_0571|M.avium_104 ALAAVP-----GNPAFVLVHDAARALTPPALIARVVQALRDGHRAVVPAL
MSMEG_6076|M.smegmatis_MC2_155 ALEAAG------DAEFVLVHDAARALTPPALIARVVAALKEGHSAVVPGL
MAB_0569|M.abscessus_ATCC_1997 GLAAVD------AADWILVHDAARPLTPPDMIARIVAELRTGRGAVIPAV
TH_2770|M.thermoresistible__bu GLDAVRNRS--TPPHHVLVHDCRRPLTPPAVVRRVRAALADGAEAVIPAL
Mflv_2529|M.gilvum_PYR-GCK MLRHLADDIDAGTVDVVAIHDAARPLAGPEMFGRAIALARQ-YGGALPAL
Mvan_4129|M.vanbaalenii_PYR-1 VLRYLADDIESGAVDVVAIHDAARPLAGPDMFVEAITLARR-FGGALPTL
* : :**. *.*: . :. . ..:* :
Mb3613c|M.bovis_AF2122/97 PLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSLDLP
Rv3582c|M.tuberculosis_H37Rv PLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSLDLP
MMAR_5082|M.marinum_M PLTDTIKAVDANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAG----
MUL_4158|M.ulcerans_Agy99 PLTDTIKAVDANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAG----
MLBr_00321|M.leprae_Br4923 PLSDTIKAVDANGMVLGTPARVGLRAVQTPQGFATELLWCAYQRGP-HLD
MAV_0571|M.avium_104 PLHDTVKAVDANGVVLGTPERDGLRAVQTPQGFATDLLLRAYAAG---AG
MSMEG_6076|M.smegmatis_MC2_155 APADTIKAVDANGAVLGTPERAGLRAVQTPQGFHADVLRRAYARAT----
MAB_0569|M.abscessus_ATCC_1997 AVADTIKSIDVHGDVIGTPDRAGLRAVQTPQGFAADVLRRAYAAAG----
TH_2770|M.thermoresistible__bu PFTDSAKTVDASGSITATLDRATLRTAQHPRGFPVDRLAQLLDGAD----
Mflv_2529|M.gilvum_PYR-GCK PTRDLAEMRDDI--LQPVARRGELVRVQTPQAFRARDLLHAYRCAE-RDG
Mvan_4129|M.vanbaalenii_PYR-1 PIRDLARQGAKG--LECIADPSTLVRVQTPQAFRARDLLHAYLRAE-RDG
. * . : * .* *:.* . * .
Mb3613c|M.bovis_AF2122/97 AAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG-----
Rv3582c|M.tuberculosis_H37Rv AAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG-----
MMAR_5082|M.marinum_M VAAFTDDASLVEHVGGQVHVVAGDPLAFKITNRLDLLLAHAVVRG-----
MUL_4158|M.ulcerans_Agy99 VSAFTDDASLVEHVGGQVHVVGGDPLAFKITNRLDLLLAHAVVRG-----
MLBr_00321|M.leprae_Br4923 AVDFTDDASLVEHLGGQVQVVAGDPLAFKITTQLDLLLAKKILRR-----
MAV_0571|M.avium_104 TAGFTDDASLVEHVGGQVQVVDGDPLAFKITTQLDLLLAETIVRR-----
MSMEG_6076|M.smegmatis_MC2_155 AGGVTDDASLVEQLGTPVQIVDGDPLAFKITTPLDLVLAEAVLARGA---
MAB_0569|M.abscessus_ATCC_1997 -DIATDDAALVEQIGERVHVVEGDRLAFKITTTLDMTLAEAILGATEGVQ
TH_2770|M.thermoresistible__bu --SAADELLEAQRVGLTLTLVDGDPDGFVVRLPDAASLVEAVITARAGRI
Mflv_2529|M.gilvum_PYR-GCK FEGTDTSSCVERYTDVQVRIFDGRATNLKVTYARDVAVAQHLLNPPGQSP
Mvan_4129|M.vanbaalenii_PYR-1 FEGTDTSSCIERYTDLEVRTFPGRAANLKVTYARDAAVAQHLLAQAGGPT
. . . : . * : : :.. ::
Mb3613c|M.bovis_AF2122/97 ---
Rv3582c|M.tuberculosis_H37Rv ---
MMAR_5082|M.marinum_M ---
MUL_4158|M.ulcerans_Agy99 ---
MLBr_00321|M.leprae_Br4923 ---
MAV_0571|M.avium_104 ---
MSMEG_6076|M.smegmatis_MC2_155 ---
MAB_0569|M.abscessus_ATCC_1997 ---
TH_2770|M.thermoresistible__bu ---
Mflv_2529|M.gilvum_PYR-GCK GS-
Mvan_4129|M.vanbaalenii_PYR-1 ALR