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DAVGVVLAAGLGTRVGADGNKAYLPLAGRSMLAWSLDTLTRLPDVARTILVFRRGEFALAHDTVRHELGD RPIEFVEGGETRHGSETNMLRHLADDIDAGTVDVVAIHDAARPLAGPEMFGRAIALARQYGGALPALPTR DLAEMRDDILQPVARRGELVRVQTPQAFRARDLLHAYRCAERDGFEGTDTSSCVERYTDVQVRIFDGRAT NLKVTYARDVAVAQHLLNPPGQSPGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2529 | - | - | 100% (237) | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3613c | ispD | 3e-15 | 30.60% (232) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. tuberculosis H37Rv | Rv3582c | ispD | 2e-15 | 31.20% (234) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. leprae Br4923 | MLBr_00321 | ispD | 3e-13 | 30.04% (233) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. abscessus ATCC 19977 | MAB_0569 | - | 2e-14 | 31.65% (218) | putative 2-C-methyl-D-erythritol 4-phosphate |
| M. marinum M | MMAR_5082 | ispD | 6e-12 | 30.63% (222) | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD |
| M. avium 104 | MAV_0571 | ispD | 2e-12 | 32.31% (229) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. smegmatis MC2 155 | MSMEG_6076 | ispD | 1e-13 | 30.26% (228) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. thermoresistible (build 8) | TH_3073 | - | 8e-71 | 58.77% (228) | PUTATIVE 2-C-methyl-D-erythritol 4-phosphate |
| M. ulcerans Agy99 | MUL_4158 | ispD | 2e-12 | 30.63% (222) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4129 | - | 3e-99 | 78.02% (232) | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00321|M.leprae_Br4923 MAVATG---TVVAVVPAAGAGKRLAAGIPKAFCELDGRTLVERAVVGLLE
MAV_0571|M.avium_104 MAPETGSSGAVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLD
Mb3613c|M.bovis_AF2122/97 MVREAG---EVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLD
Rv3582c|M.tuberculosis_H37Rv MVREAG---EVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLD
MMAR_5082|M.marinum_M MAGGTQ---GVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLLE
MUL_4158|M.ulcerans_Agy99 MAGGTQ---GVAAIVPAAGSGQRLAAGVPKAFYQLEGQTLVERAVRGLFE
MSMEG_6076|M.smegmatis_MC2_155 MA--------TVAVVPAAGSGERLRAGRPKAFVTLGGTPLLEHALSGLRA
MAB_0569|M.abscessus_ATCC_1997 ---------------------MRLGANTPKAFVSVGGRTMLQRCVDGLLA
Mflv_2529|M.gilvum_PYR-GCK --------MDAVGVVLAAGLGTRVGADGNKAYLPLAGRSMLAWSLDTLTR
Mvan_4129|M.vanbaalenii_PYR-1 --------MDAVGVVLAAGLGTRVGADGNKAYLPLAGRSMLAWSLDTLTR
TH_3073|M.thermoresistible__bu -------------VVLAAGMGTRVGADGNKAYLPLAGRSMVSWSVAAVAA
*: .. **: : * .:: .: :
MLBr_00321|M.leprae_Br4923 SGVVDHVVVAVPADRIAQTQWVLSQRLANSAGQHATVVAGGADRTKSVCQ
MAV_0571|M.avium_104 SKVVDHVVVAVPADRVDEAKRLLAA--------QATVVAGGADRTASVRL
Mb3613c|M.bovis_AF2122/97 SGVVDTVVVAVPADRTDEARQILGH--------RAMIVAGGSNRTDTVNL
Rv3582c|M.tuberculosis_H37Rv SGVVDTVVVAVPADRTDEARQILGH--------RAMIVAGGSNRTDTVNL
MMAR_5082|M.marinum_M SGVVDTVVVAVPPDRTDEAKLILGR--------EATIVAGGADRTESVSR
MUL_4158|M.ulcerans_Agy99 SGVVDTVVVAVPPDRTDEAKLILGR--------EATIVAGGADRTESVSR
MSMEG_6076|M.smegmatis_MC2_155 SGVIDRIVIAVPPALTDESKLVFGG-------EDSVIVSGGVDRTESVAL
MAB_0569|M.abscessus_ATCC_1997 SGAVDEVVVVVGADQLERAAALVGS--------GATVVQGGAERTDSVRA
Mflv_2529|M.gilvum_PYR-GCK LPDVARTILVFRRGEFALAHDTVRHELG---DRPIEFVEGGETRHGSETN
Mvan_4129|M.vanbaalenii_PYR-1 LPDIARTILVYRRGEATLARDTVQSELD---SDAVEFVEGGDTRHGSETN
TH_3073|M.thermoresistible__bu APSIDRTVLVFRRGERDVAERTIAEELP---GTAVEFVEGGDSRHGSESN
: ::. : . .* ** * :
MLBr_00321|M.leprae_Br4923 ALATLPAPSRVGAPEFILVHDAARALTPARLIVRVVDALRAGHTAVVPAL
MAV_0571|M.avium_104 ALAAVP-----GNPAFVLVHDAARALTPPALIARVVQALRDGHRAVVPAL
Mb3613c|M.bovis_AF2122/97 ALAVLSGT---AEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVL
Rv3582c|M.tuberculosis_H37Rv ALTVLSGT---AEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVL
MMAR_5082|M.marinum_M ALSALSAG---VSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVVPVL
MUL_4158|M.ulcerans_Agy99 ALSALSAG---VSPEFVLVHDAARALTPPALVVRLVDMLRAGHAAVVPVL
MSMEG_6076|M.smegmatis_MC2_155 ALEAAG------DAEFVLVHDAARALTPPALIARVVAALKEGHSAVVPGL
MAB_0569|M.abscessus_ATCC_1997 GLAAVD------AADWILVHDAARPLTPPDMIARIVAELRTGRGAVIPAV
Mflv_2529|M.gilvum_PYR-GCK MLRHLADDIDAGTVDVVAIHDAARPLAGPEMFGRAIALARQ-YGGALPAL
Mvan_4129|M.vanbaalenii_PYR-1 VLRYLADDIESGAVDVVAIHDAARPLAGPDMFVEAITLARR-FGGALPTL
TH_3073|M.thermoresistible__bu ALRHLSGDIEAGAVDVVAVHDAARPLAGADLVDAAVTVARR-HGGAVPAL
* : :*****.*: . :. : : ..:* :
MLBr_00321|M.leprae_Br4923 PLSDTIKAVD---ANGMVLGTPARVGLRAVQTPQGFATELLWCAYQRGP-
MAV_0571|M.avium_104 PLHDTVKAVD---ANGVVLGTPERDGLRAVQTPQGFATDLLLRAYAAG--
Mb3613c|M.bovis_AF2122/97 PLSDTIKAVD---ANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSL
Rv3582c|M.tuberculosis_H37Rv PLSDTIKAVD---ANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSL
MMAR_5082|M.marinum_M PLTDTIKAVD---ANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAG-
MUL_4158|M.ulcerans_Agy99 PLTDTIKAVD---ANGVVLGTPERAGLRAVQTPQGFSTELLLRAYRHAG-
MSMEG_6076|M.smegmatis_MC2_155 APADTIKAVD---ANGAVLGTPERAGLRAVQTPQGFHADVLRRAYARAT-
MAB_0569|M.abscessus_ATCC_1997 AVADTIKSID---VHGDVIGTPDRAGLRAVQTPQGFAADVLRRAYAAAG-
Mflv_2529|M.gilvum_PYR-GCK PTRDLAEMR----DDILQPVARRGE-LVRVQTPQAFRARDLLHAYRCAE-
Mvan_4129|M.vanbaalenii_PYR-1 PIRDLARQG----AKGLECIADPST-LVRVQTPQAFRARDLLHAYLRAE-
TH_3073|M.thermoresistible__bu AAPDVLRVDPSGTAEYLAPQLPDGAGVVRVQTPQAFRALPLLQAYRAAE-
. * . . : *****.* : * :* .
MLBr_00321|M.leprae_Br4923 HLDAVDFTDDASLVEHLGGQVQVVAGDPLAFKITTQLDLLLAKKILRR--
MAV_0571|M.avium_104 -AGTAGFTDDASLVEHVGGQVQVVDGDPLAFKITTQLDLLLAETIVRR--
Mb3613c|M.bovis_AF2122/97 DLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG--
Rv3582c|M.tuberculosis_H37Rv DLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG--
MMAR_5082|M.marinum_M ---VAAFTDDASLVEHVGGQVHVVAGDPLAFKITNRLDLLLAHAVVRG--
MUL_4158|M.ulcerans_Agy99 ---VSAFTDDASLVEHVGGQVHVVGGDPLAFKITNRLDLLLAHAVVRG--
MSMEG_6076|M.smegmatis_MC2_155 ---AGGVTDDASLVEQLGTPVQIVDGDPLAFKITTPLDLVLAEAVLARGA
MAB_0569|M.abscessus_ATCC_1997 ----DIATDDAALVEQIGERVHVVEGDRLAFKITTTLDMTLAEAILGATE
Mflv_2529|M.gilvum_PYR-GCK RDGFEGTDTSSCVERYTDVQVRIFDGRATNLKVTYARDVAVAQHLLNPPG
Mvan_4129|M.vanbaalenii_PYR-1 RDGFEGTDTSSCIERYTDLEVRTFPGRAANLKVTYARDAAVAQHLLAQAG
TH_3073|M.thermoresistible__bu RTGFEGTDTSSCVERFTELDIRTFPGAEHNLKVTFPADLDIADRLLRARV
.:.: . :: . * :*:* * :*. ::
MLBr_00321|M.leprae_Br4923 -------
MAV_0571|M.avium_104 -------
Mb3613c|M.bovis_AF2122/97 -------
Rv3582c|M.tuberculosis_H37Rv -------
MMAR_5082|M.marinum_M -------
MUL_4158|M.ulcerans_Agy99 -------
MSMEG_6076|M.smegmatis_MC2_155 -------
MAB_0569|M.abscessus_ATCC_1997 GVQ----
Mflv_2529|M.gilvum_PYR-GCK QSPGS--
Mvan_4129|M.vanbaalenii_PYR-1 GPTALR-
TH_3073|M.thermoresistible__bu RSVPRGR