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DFDPTAEQQAVADVVTSVLERDISWEALVCGGVTALPVPERLGGDGVGLFEVGALLTEVGRHGAVTPALA TLGLGVVPLLELASAEQQDRFLAGVAKGGVLTAALNEPGAALPDRPATSFVGGRLSGTKVGVGYAEQADW MLVTADNAVVVVSPTADGVRMVRTPTSNGSDEYVMTMDGVAVADCDILADVAAHRVNQLALAVMGAYADG LVAGALRLTADYVANRKQFGKPLSTFQTVAAQLAEVYIASRTIDLVAKSVIWRLAEDLDAGDDLGVLGYW VTSQAPPAMQICHHLHGGMGMDVTYPMHRYYSTIKDLTRLLGGPSHRLELLGARCSLT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3544c | fadE28 | - | 100% (339) | PROBABLE ACYL-CoA DEHYDROGENASE FADE28 |
| M. tuberculosis H37Rv | Rv3505 | fadE27 | 6e-36 | 30.09% (349) | acyl-CoA dehydrogenase FADE27 |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 8e-15 | 25.40% (315) | acyl-CoA dehydrogenase FADE18 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3574c | fadE28 | 0.0 | 100.00% (339) | acyl-CoA dehydrogenase FADE28 |
| M. gilvum PYR-GCK | Mflv_1509 | - | 1e-135 | 70.36% (334) | acyl-CoA dehydrogenase domain-containing protein |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-10 | 22.54% (346) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0614 | - | 1e-107 | 56.13% (351) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_5031 | fadE28 | 1e-155 | 80.47% (343) | acyl-CoA dehydrogenase FadE28 |
| M. avium 104 | MAV_0617 | - | 1e-158 | 82.53% (332) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5994 | - | 1e-140 | 72.75% (334) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0363 | fadE28 | 1e-136 | 71.51% (337) | PROBABLE ACYL-CoA DEHYDROGENASE FADE28 |
| M. ulcerans Agy99 | MUL_4105 | fadE28 | 1e-155 | 80.17% (343) | acyl-CoA dehydrogenase FadE28 |
| M. vanbaalenii PYR-1 | Mvan_5257 | - | 1e-137 | 71.26% (334) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1509|M.gilvum_PYR-GCK ----------MDFSPDEGQQAVADVVTSVLER----------------DN
Mvan_5257|M.vanbaalenii_PYR-1 ----------MDFSPDEGQQAVADVVTSVLER----------------DN
MSMEG_5994|M.smegmatis_MC2_155 ----------MDFTPNPEQQAVADVVTSVLER----------------DN
Rv3544c|M.tuberculosis_H37Rv ----------MDFDPTAEQQAVADVVTSVLER----------------DI
Mb3574c|M.bovis_AF2122/97 ----------MDFDPTAEQQAVADVVTSVLER----------------DI
MMAR_5031|M.marinum_M ----------MDFEPTAEQQAVADVVTSVLAR----------------DL
MUL_4105|M.ulcerans_Agy99 ----------MDFEPTAEQQAVADVVTSVLAR----------------DL
MAV_0617|M.avium_104 ----MASETTMDFDPSPTQQAVADVVTSVLDR----------------EL
TH_0363|M.thermoresistible__bu ----------VDFSPNEGQQAVADVVTSVLSR----------------ET
MAB_0614|M.abscessus_ATCC_1997 ----------MDFAFAEEQQAVSDVVEAVLADREFVGVVPEIG---YDEA
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
* :: : .: :: :
Mflv_1509|M.gilvum_PYR-GCK TWDALVSGGVTALAVPERLGGDGVGLAEIATALTEIGRHGTVSPALVTLG
Mvan_5257|M.vanbaalenii_PYR-1 TWDALVSGGVTALGVPERLGGDGVGFAEMATALTEIGRHGTISPALVTLG
MSMEG_5994|M.smegmatis_MC2_155 SWDALVSGGVTALAVPERLGGDGLGLAEVATALTEIGRRGTVSPALATLG
Rv3544c|M.tuberculosis_H37Rv SWEALVCGGVTALPVPERLGGDGVGLFEVGALLTEVGRHGAVTPALATLG
Mb3574c|M.bovis_AF2122/97 SWEALVCGGVTALPVPERLGGDGVGLFEVGALLTEVGRHGAVTPALATLG
MMAR_5031|M.marinum_M TWTALVDGGVTALAVPERLGGDGVGLLEVSTVLAEVGRHGAVTPALATLG
MUL_4105|M.ulcerans_Agy99 TWTALVDGGVTALAVPERLGGDGVGLLEVSTVLAEVGRHGAVTPALATLG
MAV_0617|M.avium_104 SWEALVDGGVTALPVPERLGGDGVGLPEVATVLTEVGRRGAITPALATLG
TH_0363|M.thermoresistible__bu SWDALVSGGVAALPVPERLGGDGVGLAEVATALTEIGRHGAVGPALATLG
MAB_0614|M.abscessus_ATCC_1997 AWRALAANGVLSLALPERLGGDGLGLAEVSVALRVLGKHGALTPALATLG
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
: ** .*. :: :**. **:* . : :.: .: . : ::.
Mflv_1509|M.gilvum_PYR-GCK -ATAV-LLDLAADTQQNRYLAG-VAKGSVVTLALNEPGVSLPDHPGVTLA
Mvan_5257|M.vanbaalenii_PYR-1 -TTAV-LLDLASEAQQDRYLGG-VAKGSVLTLALNEPGAQLPDRPAVALA
MSMEG_5994|M.smegmatis_MC2_155 -LGLVPLLDLASEAQQDRYLAQ-VDKGAVLSAALSEPGRHLPQQPATTFA
Rv3544c|M.tuberculosis_H37Rv -LGVVPLLELASAEQQDRFLAG-VAKGGVLTAALNEPGAALPDRPATSFV
Mb3574c|M.bovis_AF2122/97 -LGVVPLLELASAEQQDRFLAG-VAKGGVLTAALNEPGAALPDRPATSFV
MMAR_5031|M.marinum_M -LGVVPLLALASEAQQDRILAG-VAKGAVLSAALNEPGVALPDRPATRFA
MUL_4105|M.ulcerans_Agy99 -LGVVPLLALASEAQQDRILAG-VAKGAVLSAALNEPGVALPDRPATRFA
MAV_0617|M.avium_104 -FAVLPLLELASEEQQDRFLAG-VARGGVLTAALNEPGTPLPDRPATTFA
TH_0363|M.thermoresistible__bu -LAVTPLLELASEEQQDRYLAG-VAEGAILTAALNEPGAALPDRPATSLR
MAB_0614|M.abscessus_ATCC_1997 -FGVVPLVELASGEQQDRYLAG-VGDGAILTAALDEPGRAVPSAPAVSAV
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
*: .: :.: * . *.: : **.* .
Mflv_1509|M.gilvum_PYR-GCK --GGR---LNGTKIAVGYAAQADWLVVTTDS---------GVVVVPGDAD
Mvan_5257|M.vanbaalenii_PYR-1 --AGK---LNGTKVGVGYAAQADWIVVTTDN---------GVVVVPGKAD
MSMEG_5994|M.smegmatis_MC2_155 --GGV---LNGTKIGVPYAGSAQWLVVTADT---------AVVVVSPTAA
Rv3544c|M.tuberculosis_H37Rv --GGR---LSGTKVGVGYAEQADWMLVTADN---------AVVVVSPTAD
Mb3574c|M.bovis_AF2122/97 --GGR---LSGTKVGVGYAEQADWMLVTADN---------AVVVVSPTAD
MMAR_5031|M.marinum_M --NGR---LSGTKLGVAYAGQADWLIVTADG---------AVVVVSPKAD
MUL_4105|M.ulcerans_Agy99 --NGR---LSGTKLGVAYAGQADWLIVTADG---------AVVVVSSKAD
MAV_0617|M.avium_104 --DGR---LSGTKIGVGYAAQADWMIVTADS---------AVVVVSPKAD
TH_0363|M.thermoresistible__bu --GGK---LNGTKVAVGYAAQAQWMVVSTDA---------GVVVVSPNAA
MAB_0614|M.abscessus_ATCC_1997 R-DGSSLVLNGRKIGVLHAAEAHWILVTTDN---------GVVVVAPNTP
MLBr_00737|M.leprae_Br4923 KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDE
* *.* * : . .: * * : ...:*
Mflv_1509|M.gilvum_PYR-GCK GIAVTVTPTAN---GGEEAAVTFTDVAVSDDDVLAGA-----EVSRVNQL
Mvan_5257|M.vanbaalenii_PYR-1 GLTVTKTPTSN---GSDEYVLAFADVAVADADVLEGA-----TPHRVNQL
MSMEG_5994|M.smegmatis_MC2_155 GVTLTKTPTAN---GSDEYAVTFADVAVSDDDVLAGA-----TATRVNQL
Rv3544c|M.tuberculosis_H37Rv GVRMVRTPTSN---GSDEYVMTMDGVAVADCDILADV-----AAHRVNQL
Mb3574c|M.bovis_AF2122/97 GVRMVRTPTSN---GSDEYVMTMDGVAVADCDILADV-----AAHRVNQL
MMAR_5031|M.marinum_M GVQLVQTPTSN---GSVEYTVSFHDVVVSESDVLAGA-----TAPRVNQL
MUL_4105|M.ulcerans_Agy99 GVQLVQTPTSN---GSVEYTVSFHDVVVSESDVLAGA-----TAPRVNQL
MAV_0617|M.avium_104 GVQVVQTPTSN---GSDEYTVSFTGVAVADSDVLAGA-----TAARVNQL
TH_0363|M.thermoresistible__bu GVQITKSPTAN---GTDEYSVTFTDVEVPDADVLDGA-----TVARLNQY
MAB_0614|M.abscessus_ATCC_1997 GVTITRTPTAS---KAAEYAVTFSDVSVPAADQLSG------SVQRLNEL
MLBr_00737|M.leprae_Br4923 GFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDH
*. : . . : : :. : :
Mflv_1509|M.gilvum_PYR-GCK SLAAIGAFAAGLVAGALRLTADYVANREQFGRPLSTFQTVAAQLSEVYIA
Mvan_5257|M.vanbaalenii_PYR-1 VLAAVGAFSAGLVAGALRLTADYVATREQFGRPLSTFQTVAAQLSEVYIA
MSMEG_5994|M.smegmatis_MC2_155 ALAAIGAFGAGLVAGALRLTADYVATREQFGRPLSTFQTVAAQLSEVYIA
Rv3544c|M.tuberculosis_H37Rv ALAVMGAYADGLVAGALRLTADYVANRKQFGKPLSTFQTVAAQLAEVYIA
Mb3574c|M.bovis_AF2122/97 ALAVMGAYADGLVAGALRLTADYVANRKQFGKPLSTFQTVAAQLAEVYIA
MMAR_5031|M.marinum_M ALAMLGAYADGLVAGALRLTADYVANRKQFGKPLSTFQTVAAQLAEVYIA
MUL_4105|M.ulcerans_Agy99 ALAMLGAYADGLVAGALRLTADYVANRKQFGKPLSTFQTVAAQLAEVYIA
MAV_0617|M.avium_104 ALAAVGAYADGLVSGALRLTADYVANRKQFGKPLSTFQTVAAQLAEVYIA
TH_0363|M.thermoresistible__bu ALAAIGAYAAGLVAGALRLTADYVANREQFGKPLSTFQTVAAHLAEVYIA
MAB_0614|M.abscessus_ATCC_1997 ALAAIGSYADGLVSGALRLTADHVSNRVQFGKPLATFQAVSQQLADVYVV
MLBr_00737|M.leprae_Br4923 TRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMK
. :*: . *:. *** : :. * ***..::***:: *::: :
Mflv_1509|M.gilvum_PYR-GCK SRTIDLVSNSVVWRLSE----GLDAEDDLAILGYWLTSQAPPAMRLCHHL
Mvan_5257|M.vanbaalenii_PYR-1 SRTISLLSTSVAWQLTE----GRDAADDLAILGYWLASQAPPAMRLCHHL
MSMEG_5994|M.smegmatis_MC2_155 SRTIDLVSTSVVWRLSE----GLDAEEDLAILGFWLTTQAPPAMRLCHHL
Rv3544c|M.tuberculosis_H37Rv SRTIDLVAKSVIWRLAE----DLDAGDDLGVLGYWVTSQAPPAMQICHHL
Mb3574c|M.bovis_AF2122/97 SRTIDLVAKSVIWRLAE----DLDAGDDLGVLGYWVTSQAPPAMQICHHL
MMAR_5031|M.marinum_M SRTIDLAAKSVIWRLAAGRENDPQTGDDLDVLGYWVTSQAPPVMQICHHL
MUL_4105|M.ulcerans_Agy99 SRTIDLAAKSVIWRLAAGRENDPQTGDDLDVLGYWVTSQAPPVMQICHHL
MAV_0617|M.avium_104 SRTIDLVAKSVVWGLSE----GRDVDHDLGVLGYWVASQAPPAMQLCHHL
TH_0363|M.thermoresistible__bu SRTLDLASTSVIWRLSEGPADDPQTREDLAVLGYWLAAEAPPVMQLCHHL
MAB_0614|M.abscessus_ATCC_1997 SRTLNLGVTSAVWRLCE----GLDATEDLDIVSFWMAAEAQRVMQICHHL
MLBr_00737|M.leprae_Br4923 VEAARLIVYAAAARAERG---EPDLGFISAASKCFASDIAMEVTTDAVQL
.: * :. : : : * . . :*
Mflv_1509|M.gilvum_PYR-GCK HGGMGMDITYPMDRYYSSIKDLTRLLGGPTHRLDLVGA------------
Mvan_5257|M.vanbaalenii_PYR-1 HGGMGMDITYPMDRYYSSIKDLTRLLGGPSHRLDLVGA------------
MSMEG_5994|M.smegmatis_MC2_155 HGGMGMDITYPMDRYFSSIKDLTRLLGGPAHRLDLVGA------------
Rv3544c|M.tuberculosis_H37Rv HGGMGMDVTYPMHRYYSTIKDLTRLLGGPSHRLELLGARCSLT-------
Mb3574c|M.bovis_AF2122/97 HGGMGMDVTYPMHRYYSTIKDLTRLLGGPSHRLELLGARCSLT-------
MMAR_5031|M.marinum_M HGGMGMDVTYPMHRYYSTIKDLSRLLGGPAHRLDLVGAQCSST-------
MUL_4105|M.ulcerans_Agy99 HGGMGMDVTYPMHRYYSTIKDLSRLLGGPAHRLDLVGAQCSST-------
MAV_0617|M.avium_104 HGGMGMDITYPMHRYYSTIKDLTRLLGGPSHRLDLVAIASTAQPGAAGRH
TH_0363|M.thermoresistible__bu HGGMGMDIDYPMDRYYSTIKDLTRLVGGPSRCLDRLGGLDLADAAVGGRG
MAB_0614|M.abscessus_ATCC_1997 HGGLGVDITYPMNRYYSTIKDLSRLVGGSSERLDVLAAAQG---------
MLBr_00737|M.leprae_Br4923 FGGAGYTSDFPVERFMRDAK-ITQIYEGTNQIQRVVMSRALLR-------
.** * :*:.*: * :::: *. . :
Mflv_1509|M.gilvum_PYR-GCK ----------
Mvan_5257|M.vanbaalenii_PYR-1 ----------
MSMEG_5994|M.smegmatis_MC2_155 ----------
Rv3544c|M.tuberculosis_H37Rv ----------
Mb3574c|M.bovis_AF2122/97 ----------
MMAR_5031|M.marinum_M ----------
MUL_4105|M.ulcerans_Agy99 ----------
MAV_0617|M.avium_104 ADDLVGAQCS
TH_0363|M.thermoresistible__bu PGDDGN----
MAB_0614|M.abscessus_ATCC_1997 ----------
MLBr_00737|M.leprae_Br4923 ----------