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DFTTTEAAHDLGNLVDTIVDSVCTPEHQRELDGLDQRFDRDLWAKLIDAGILSSASATSLGGDGFGALEQ IAILVALGHQLAAVPYLESVVLGAGALARFGTEELQQGWGVPAVSGEKTLTVALDPEMGEGPVQAVSAGA GYRLTGTRTQVGFGPVADAFLVPAETDSGTAVFLVAADDPGVTVTALETTGLGSVGHLALDGTQVDGTRQ VGGAEVAAWLGTLGTLGRAAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVSQRLADGYIDVKGLRLT LTQAAWRVSEDLPAEVDVATAAFWAADAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKQAEFALGGATG QLRRIGRELAETPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0651 | - | - | 100% (365) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1336 | - | 5e-68 | 40.54% (370) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_0617 | - | 2e-35 | 29.29% (338) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3535 | fadE27 | 1e-179 | 83.91% (373) | acyl-CoA dehydrogenase FADE27 |
| M. gilvum PYR-GCK | Mflv_1550 | - | 1e-154 | 74.25% (369) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3505 | fadE27 | 1e-179 | 84.18% (373) | acyl-CoA dehydrogenase FADE27 |
| M. leprae Br4923 | MLBr_00661 | fadE24 | 3e-16 | 28.50% (207) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4159 | - | 1e-137 | 67.67% (365) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4993 | fadE27 | 1e-180 | 84.93% (365) | acyl-CoA dehydrogenase FadE27 |
| M. smegmatis MC2 155 | MSMEG_5907 | - | 1e-153 | 73.90% (364) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3575 | - | 4e-94 | 68.08% (260) | PUTATIVE acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4068 | fadE27 | 1e-180 | 84.93% (365) | acyl-CoA dehydrogenase FadE27 |
| M. vanbaalenii PYR-1 | Mvan_5207 | - | 1e-152 | 73.71% (369) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3535|M.bovis_AF2122/97 -------------------------------------MDFTTTEAAQDLG
Rv3505|M.tuberculosis_H37Rv -------------------------------------MDFTTTEAAQDLG
MMAR_4993|M.marinum_M -------------------------------------MDFSTTEAAQDLG
MUL_4068|M.ulcerans_Agy99 -------------------------------------MDFSTTEAAQDLG
MAV_0651|M.avium_104 -------------------------------------MDFTTTEAAHDLG
Mflv_1550|M.gilvum_PYR-GCK -------------------------------------MDFTTTEASEDLG
Mvan_5207|M.vanbaalenii_PYR-1 -------------------------------------MDFKTTEASEDLG
MSMEG_5907|M.smegmatis_MC2_155 -------------------------------------MDFTTTEAAADLG
MAB_4159|M.abscessus_ATCC_1997 -------------------------------------MDFSLTEAQTDLA
TH_3575|M.thermoresistible__bu -------------------------------------MDFTSTEAAEELG
MLBr_00661|M.leprae_Br4923 MTDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLVGQDFL
: : . . ::
Mb3535|M.bovis_AF2122/97 ---------------GLVDTIVDAVCTPEHQRELDKLE------------
Rv3505|M.tuberculosis_H37Rv ---------------GLVDTIVDAVCTPEHQRELDKLE------------
MMAR_4993|M.marinum_M ---------------GLVDTIVDAVCTPEHQRQLDRLE------------
MUL_4068|M.ulcerans_Agy99 ---------------GLVATIVDAVCTPEHQRQLDGLE------------
MAV_0651|M.avium_104 ---------------NLVDTIVDSVCTPEHQRELDGLD------------
Mflv_1550|M.gilvum_PYR-GCK ---------------GLVRTITESVCTPEHQRELDGLGP-----------
Mvan_5207|M.vanbaalenii_PYR-1 ---------------GLVRTITESVCTPEHQRELDGLRP-----------
MSMEG_5907|M.smegmatis_MC2_155 ---------------GLVRTITESVCTPEHQRELDGLP------------
MAB_4159|M.abscessus_ATCC_1997 ---------------GLTRTIASTISTPERQKELDKQD------------
TH_3575|M.thermoresistible__bu ---------------GLVRTITESVCTHEHQRELDKLE------------
MLBr_00661|M.leprae_Br4923 DKYHLRYPLNRALRYGVKATFSTAAATSRQFKRVQNLRGGATRLQPSGRN
.: *: : .* .: :.::
Mb3535|M.bovis_AF2122/97 -----------------------------------QRFDRELWRKLIDAG
Rv3505|M.tuberculosis_H37Rv -----------------------------------QRFDRELWRKLIDAG
MMAR_4993|M.marinum_M -----------------------------------QRFDRELWRKLIDSD
MUL_4068|M.ulcerans_Agy99 -----------------------------------QRFDRELWRKLIDSD
MAV_0651|M.avium_104 -----------------------------------QRFDRDLWAKLIDAG
Mflv_1550|M.gilvum_PYR-GCK --------------------------------DAGGRFDKTLWSKLIDAD
Mvan_5207|M.vanbaalenii_PYR-1 --------------------------------EAGGRFDRDLWGKLIDAD
MSMEG_5907|M.smegmatis_MC2_155 -----------------------------------ERFDRDLWAKLVEAD
MAB_4159|M.abscessus_ATCC_1997 -----------------------------------SRFDRQLWTKLAEAD
TH_3575|M.thermoresistible__bu -----------------------------------QRFDTELWAKLIDAD
MLBr_00661|M.leprae_Br4923 YFDLTPDDNQKLIVETIDEFSAEILRPAAHDADEAAAYPPDLIAKAAKLG
: * * . .
Mb3535|M.bovis_AF2122/97 ILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLA---AGAL
Rv3505|M.tuberculosis_H37Rv ILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLA---AGAL
MMAR_4993|M.marinum_M ILSSAAATQVGGDGFGVLEQVAILVALGHQLAAVPYLESVVLA---AGAL
MUL_4068|M.ulcerans_Agy99 ILSSAAATQVGGDGFGVLEQVAILVALGHQLAAVPYLESVVLA---AGAL
MAV_0651|M.avium_104 ILSSASATSLGGDGFGALEQIAILVALGHQLAAVPYLESVVLG---AGAL
Mflv_1550|M.gilvum_PYR-GCK VLSTTAPESLGGGGFGVLEEVAVLVALGRQLAAVPYLESVVLG---AGAL
Mvan_5207|M.vanbaalenii_PYR-1 ILSTTSPESLGGGGFGVLEEVAVLVALGRQLAAVPYLESVMLA---AGAL
MSMEG_5907|M.smegmatis_MC2_155 ILSAAAPESVGGGGFGVLEQTSVLTALGRQLAAVPYLESVVAA---AGAI
MAB_4159|M.abscessus_ATCC_1997 ILSTAAPESVGGAGFGVLEQSSILVELGRELAAVPYLESVVLA---AGAL
TH_3575|M.thermoresistible__bu VLSTAAPESIGGGGFGVLEQVAVLVALGRQLGAVPYLESVVLG---AGAL
MLBr_00661|M.leprae_Br4923 ITTINIPEYFDGIAERRSSVTNVLVAEALAYGDMGLTLPILAPGGVAATL
: : . ..* . . :*. . . : .:: *.::
Mb3535|M.bovis_AF2122/97 ARFGSPELQQGWGVSAVSG--DRILTVALDGEMGEGPVQAAGTGH----G
Rv3505|M.tuberculosis_H37Rv ARFGSPELQQGWGVSAVSG--DRILTVALDGEMGEGPVQAAGTGH----G
MMAR_4993|M.marinum_M ARFGSEELQQSWGAAAVGG--EKILAVALDAEMGEGPVQAARSGA----G
MUL_4068|M.ulcerans_Agy99 ARFGSEELQQSWGAAAVGG--EKILAVALDAEMGEGPVQAARSGA----G
MAV_0651|M.avium_104 ARFGTEELQQGWGVPAVSG--EKTLTVALDPEMGEGPVQAVSAGA----G
Mflv_1550|M.gilvum_PYR-GCK ARFGDDGLQQQWAAPAVTG--DKVLTVALDGEMGEGPVRATTTAD----G
Mvan_5207|M.vanbaalenii_PYR-1 ATFGSASLQQDWAAQAIKG--EKVLAVAFDGEMGEGPVLAQGSGD----G
MSMEG_5907|M.smegmatis_MC2_155 AEFGSDAQRAEWGAPAVAG--SKILTVALDGEMGQGPVQAQADGD----D
MAB_4159|M.abscessus_ATCC_1997 AAFGSEAMRNDWAAPAVAG--KKVLTIALEGEPGEGPVAARTEGT----G
TH_3575|M.thermoresistible__bu AEFGSDAQREQWAAPAVGG--QRILTAALEGETGEGPVRAEVNADS---G
MLBr_00661|M.leprae_Br4923 TYWGSADQQATYLKEFTGENVPQACVAIAEPQPLFDPTRLKTIAVRTPSG
: :* : : : . : : .*. . .
Mb3535|M.bovis_AF2122/97 YRLTGTRTQVGYGPVADAFLVPAETDSGAAVFLVAAGDPGVAVTALATTG
Rv3505|M.tuberculosis_H37Rv YRLTGTRTQVGYGPVADAFLVPAETDSGAAVFLVAAGDPGVAVTALATTG
MMAR_4993|M.marinum_M FRLTGTRTQVGYGPVADAFLVPAETDSGTVVFLVAADDPGVSVTALQTTG
MUL_4068|M.ulcerans_Agy99 FRLTGTRTQVGYGPVADAFLVPAETDSGTVVFLVAADDPGVSVTALQTTG
MAV_0651|M.avium_104 YRLTGTRTQVGFGPVADAFLVPAETDSGTAVFLVAADDPGVTVTALETTG
Mflv_1550|M.gilvum_PYR-GCK VTLTGTRTQVPFAVGADAFLVPAETDSGVAVFLVAAADAGVTVTPLDTTG
Mvan_5207|M.vanbaalenii_PYR-1 YTLTGSRTQVAFGVNADAFLVPAETDSGTAVFLVGSADDGVAVTALDTTG
MSMEG_5907|M.smegmatis_MC2_155 HRLTGSRTLVSYGPVADAYLVPAETGSGVSVFIVAADDAGVTETSLNTTG
MAB_4159|M.abscessus_ATCC_1997 YVLTGNRVLVPFGVEADAYLVPAETETGTAVFLVSADDAGVTQQALHTTG
TH_3575|M.thermoresistible__bu HTLTGTRTLVRFGPVADGFLVPAETDSGTRVFLVAADDPGVTVTALNTTG
MLBr_00661|M.leprae_Br4923 YRLDGVKSLVPAAASAELFIIGAQLNGKPALFIVESSTKGLTVKADPSMG
* * : * . *: ::: *: :*:* : *:: . : *
Mb3535|M.bovis_AF2122/97 L--GSVGHLELNGAKVDAARRVG---GTD-VVVWLGTLSTLSRTAFQLGV
Rv3505|M.tuberculosis_H37Rv L--GSVGHLELNGAKVDAARRVG---GTD-VAVWLGTLSTLSRTAFQLGV
MMAR_4993|M.marinum_M L--GSVGHLALDGTEVDAARGIG---GSD-VTAWLRTINTLGRSAFQLGV
MUL_4068|M.ulcerans_Agy99 L--GSVGHLALDGTEVDAARGIG---GSD-VTAWLRTINTLGRSAFQLGV
MAV_0651|M.avium_104 L--GSVGHLALDGTQVDGTRQVG---GAE-VAAWLGTLGTLGRAAFQLGV
Mflv_1550|M.gilvum_PYR-GCK H--GSVAALDLQGVGITGDRRVG---GSE-VLDWLVTRNALARSAYQLGV
Mvan_5207|M.vanbaalenii_PYR-1 H--GSVAGLQLQGVAIGSDRRVG---GPE-VLDWLVTRHALGRSAYQLGV
MSMEG_5907|M.smegmatis_MC2_155 K--GSVAHLDLQDVAVGADRVLG---GTQ-VAEWLTTRVTLGRTAYQLGV
MAB_4159|M.abscessus_ATCC_1997 K--DSSAELILSEVPVPAERKVG---GAE-VVEWLRLRESLGHSAYQLGV
TH_3575|M.thermoresistible__bu R--GSVGRLELAGTVLPPDRTVG---ADEAALRWIKIRNILGHSAFQLGV
MLBr_00661|M.leprae_Br4923 IRAAALGQVELCGVSAPLDARLGEDDATDNDYSEAIALARLGWAALAVGT
: . : * . :* . : *. :* :*.
Mb3535|M.bovis_AF2122/97 LERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAA
Rv3505|M.tuberculosis_H37Rv LERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAA
MMAR_4993|M.marinum_M LERGLRMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAA
MUL_4068|M.ulcerans_Agy99 LERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAA
MAV_0651|M.avium_104 LERGLQMTAEYARTREQFDRPIGSFQAVSQRLADGYIDVKGLRLTLTQAA
Mflv_1550|M.gilvum_PYR-GCK VERALELTAQYAREREQFDRPIGSFQAVSSRLADGYIDIKGLRLTVTQAA
Mvan_5207|M.vanbaalenii_PYR-1 LERALELTASYAREREQFDRPIGSFQAVSSRLADGYIDIKGLRLTLTQAA
MSMEG_5907|M.smegmatis_MC2_155 LERALELTASYAREREQFDRPIGSFQAVSSRLADGYIDVKGLRLTLTQAA
MAB_4159|M.abscessus_ATCC_1997 LERALELTADYARTREQFGKPIGGFQAVAQRLADGYIDVKGLCLTLWQAA
TH_3575|M.thermoresistible__bu LERALEMTAAYAREREQFDRPLX---XXAGGCAGGGVPAG----------
MLBr_00661|M.leprae_Br4923 SHAVLDYVMPYVKEREAFGEPIARRQAVAFMCANIAIELDGLRLITWRGA
. * . *.: ** *..*: . *. :
Mb3535|M.bovis_AF2122/97 WRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDT
Rv3505|M.tuberculosis_H37Rv WRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDT
MMAR_4993|M.marinum_M WRVSED--------LPAEIDVASAGFWAAEAGHRVAHTIVHVHGGVGVDT
MUL_4068|M.ulcerans_Agy99 WRVSED--------LPAEIDVASAGFCAAEAGHRVAHTIVHVHGGVGVDT
MAV_0651|M.avium_104 WRVSED--------LPAEVDVATAAFWAADAGHRVAHTIVHVHGGVGVDT
Mflv_1550|M.gilvum_PYR-GCK WRVSED--------LPADVDVASAAFWAAEAGHRVAHTAVHVHGGVGIDI
Mvan_5207|M.vanbaalenii_PYR-1 WRLSED--------LPADLDVASAAFWAAEAGHRVAHTTVHVHGGVGIDI
MSMEG_5907|M.smegmatis_MC2_155 WRLSED--------LPADVDVASAAFWAAEAGHRVAHTAVHVHGGVGIDM
MAB_4159|M.abscessus_ATCC_1997 WRVSED--------LPSDVDVATAKFWAADAGHRVAHTAVHVHGGVGIDE
TH_3575|M.thermoresistible__bu --------------RPGHRGAAVGGGRAGPSG-RTAHPGRPGH-------
MLBr_00661|M.leprae_Br4923 SRAEQG--------LSFAREAALAKRLGSDKAMQIGLDGVQLLGGHGFIK
. .* . .. . : .
Mb3535|M.bovis_AF2122/97 DHPVHRYFLAAKQTEFALGGATGQLRRIGRELAETPA
Rv3505|M.tuberculosis_H37Rv DHPVHRYFLAAKQTEFALGGATGQLRRIGRELAETPA
MMAR_4993|M.marinum_M DHPVHRYFLAAKEAEFALGGATTALRQIGRELAETPA
MUL_4068|M.ulcerans_Agy99 DHPVHRYFLAAKEAEFALGGATTALRQIGRELAETPA
MAV_0651|M.avium_104 DHPVHRYFLAAKQAEFALGGATGQLRRIGRELAETPA
Mflv_1550|M.gilvum_PYR-GCK DHPVHRYFLAAKQTEFAVGGATGQLLRIGRELADTPA
Mvan_5207|M.vanbaalenii_PYR-1 DHPVHRYFLAAKQTEFAVGGATGQLLRIGRELADTPA
MSMEG_5907|M.smegmatis_MC2_155 DHPVHRYFLAAKQSEFALGSATGQLLRIGRELADTPV
MAB_4159|M.abscessus_ATCC_1997 DHPVHRYFLAAKRGEFASGSATEQLRRIGRELADTPA
TH_3575|M.thermoresistible__bu ---LRRRARDGVQDAAGRCADGGGARRW---------
MLBr_00661|M.leprae_Br4923 EHPVERWYRDLR----AIGVAEGVVVI----------
:.* .