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MDFSTTEAAQDLGGLVATIVDAVCTPEHQRQLDGLEQRFDRELWRKLIDSDILSSAAATQVGGDGFGVLE QVAILVALGHQLAAVPYLESVVLAAGALARFGSEELQQSWGAAAVGGEKILAVALDAEMGEGPVQAARSG AGFRLTGTRTQVGYGPVADAFLVPAETDSGTVVFLVAADDPGVSVTALQTTGLGSVGHLALDGTEVDAAR GIGGSDVTAWLRTINTLGRSAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRL TLTQAAWRVSEDLPAEIDVASAGFCAAEAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKEAEFALGGAT TALRQIGRELAETPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4068 | fadE27 | - | 100% (365) | acyl-CoA dehydrogenase FadE27 |
| M. ulcerans Agy99 | MUL_2893 | fadE18 | 1e-31 | 30.51% (354) | acyl-CoA dehydrogenase FadE18 |
| M. ulcerans Agy99 | MUL_4105 | fadE28 | 2e-30 | 29.80% (349) | acyl-CoA dehydrogenase FadE28 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3535 | fadE27 | 1e-176 | 83.65% (373) | acyl-CoA dehydrogenase FADE27 |
| M. gilvum PYR-GCK | Mflv_1550 | - | 1e-147 | 71.00% (369) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3505 | fadE27 | 1e-176 | 83.65% (373) | acyl-CoA dehydrogenase FADE27 |
| M. leprae Br4923 | MLBr_00661 | fadE24 | 4e-15 | 26.57% (207) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4159 | - | 1e-134 | 65.75% (365) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4993 | fadE27 | 0.0 | 98.90% (365) | acyl-CoA dehydrogenase FadE27 |
| M. avium 104 | MAV_0651 | - | 1e-179 | 84.93% (365) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5907 | - | 1e-149 | 72.25% (364) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3575 | - | 1e-93 | 66.92% (260) | PUTATIVE acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5207 | - | 1e-149 | 71.82% (369) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4068|M.ulcerans_Agy99 -------------------------------------MDFSTTEAAQDLG
MMAR_4993|M.marinum_M -------------------------------------MDFSTTEAAQDLG
Mb3535|M.bovis_AF2122/97 -------------------------------------MDFTTTEAAQDLG
Rv3505|M.tuberculosis_H37Rv -------------------------------------MDFTTTEAAQDLG
MAV_0651|M.avium_104 -------------------------------------MDFTTTEAAHDLG
Mflv_1550|M.gilvum_PYR-GCK -------------------------------------MDFTTTEASEDLG
Mvan_5207|M.vanbaalenii_PYR-1 -------------------------------------MDFKTTEASEDLG
MSMEG_5907|M.smegmatis_MC2_155 -------------------------------------MDFTTTEAAADLG
MAB_4159|M.abscessus_ATCC_1997 -------------------------------------MDFSLTEAQTDLA
TH_3575|M.thermoresistible__bu -------------------------------------MDFTSTEAAEELG
MLBr_00661|M.leprae_Br4923 MTDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLVGQDFL
: : . . ::
MUL_4068|M.ulcerans_Agy99 ---------------GLVATIVDAVCTPEHQRQLDGLE------------
MMAR_4993|M.marinum_M ---------------GLVDTIVDAVCTPEHQRQLDRLE------------
Mb3535|M.bovis_AF2122/97 ---------------GLVDTIVDAVCTPEHQRELDKLE------------
Rv3505|M.tuberculosis_H37Rv ---------------GLVDTIVDAVCTPEHQRELDKLE------------
MAV_0651|M.avium_104 ---------------NLVDTIVDSVCTPEHQRELDGLD------------
Mflv_1550|M.gilvum_PYR-GCK ---------------GLVRTITESVCTPEHQRELDGLGP-----------
Mvan_5207|M.vanbaalenii_PYR-1 ---------------GLVRTITESVCTPEHQRELDGLRP-----------
MSMEG_5907|M.smegmatis_MC2_155 ---------------GLVRTITESVCTPEHQRELDGLP------------
MAB_4159|M.abscessus_ATCC_1997 ---------------GLTRTIASTISTPERQKELDKQD------------
TH_3575|M.thermoresistible__bu ---------------GLVRTITESVCTHEHQRELDKLE------------
MLBr_00661|M.leprae_Br4923 DKYHLRYPLNRALRYGVKATFSTAAATSRQFKRVQNLRGGATRLQPSGRN
.: *: : .* .: :.::
MUL_4068|M.ulcerans_Agy99 -----------------------------------QRFDRELWRKLIDSD
MMAR_4993|M.marinum_M -----------------------------------QRFDRELWRKLIDSD
Mb3535|M.bovis_AF2122/97 -----------------------------------QRFDRELWRKLIDAG
Rv3505|M.tuberculosis_H37Rv -----------------------------------QRFDRELWRKLIDAG
MAV_0651|M.avium_104 -----------------------------------QRFDRDLWAKLIDAG
Mflv_1550|M.gilvum_PYR-GCK --------------------------------DAGGRFDKTLWSKLIDAD
Mvan_5207|M.vanbaalenii_PYR-1 --------------------------------EAGGRFDRDLWGKLIDAD
MSMEG_5907|M.smegmatis_MC2_155 -----------------------------------ERFDRDLWAKLVEAD
MAB_4159|M.abscessus_ATCC_1997 -----------------------------------SRFDRQLWTKLAEAD
TH_3575|M.thermoresistible__bu -----------------------------------QRFDTELWAKLIDAD
MLBr_00661|M.leprae_Br4923 YFDLTPDDNQKLIVETIDEFSAEILRPAAHDADEAAAYPPDLIAKAAKLG
: * * . .
MUL_4068|M.ulcerans_Agy99 ILSSAAATQVGGDGFGVLEQVAILVALGHQLAAVPYLESVVLA---AGAL
MMAR_4993|M.marinum_M ILSSAAATQVGGDGFGVLEQVAILVALGHQLAAVPYLESVVLA---AGAL
Mb3535|M.bovis_AF2122/97 ILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLA---AGAL
Rv3505|M.tuberculosis_H37Rv ILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLA---AGAL
MAV_0651|M.avium_104 ILSSASATSLGGDGFGALEQIAILVALGHQLAAVPYLESVVLG---AGAL
Mflv_1550|M.gilvum_PYR-GCK VLSTTAPESLGGGGFGVLEEVAVLVALGRQLAAVPYLESVVLG---AGAL
Mvan_5207|M.vanbaalenii_PYR-1 ILSTTSPESLGGGGFGVLEEVAVLVALGRQLAAVPYLESVMLA---AGAL
MSMEG_5907|M.smegmatis_MC2_155 ILSAAAPESVGGGGFGVLEQTSVLTALGRQLAAVPYLESVVAA---AGAI
MAB_4159|M.abscessus_ATCC_1997 ILSTAAPESVGGAGFGVLEQSSILVELGRELAAVPYLESVVLA---AGAL
TH_3575|M.thermoresistible__bu VLSTAAPESIGGGGFGVLEQVAVLVALGRQLGAVPYLESVVLG---AGAL
MLBr_00661|M.leprae_Br4923 ITTINIPEYFDGIAERRSSVTNVLVAEALAYGDMGLTLPILAPGGVAATL
: : . ..* . . :*. . . : .:: *.::
MUL_4068|M.ulcerans_Agy99 ARFGSEELQQSWGAAAVGG--EKILAVALDAEMGEGPVQAARSGA----G
MMAR_4993|M.marinum_M ARFGSEELQQSWGAAAVGG--EKILAVALDAEMGEGPVQAARSGA----G
Mb3535|M.bovis_AF2122/97 ARFGSPELQQGWGVSAVSG--DRILTVALDGEMGEGPVQAAGTGH----G
Rv3505|M.tuberculosis_H37Rv ARFGSPELQQGWGVSAVSG--DRILTVALDGEMGEGPVQAAGTGH----G
MAV_0651|M.avium_104 ARFGTEELQQGWGVPAVSG--EKTLTVALDPEMGEGPVQAVSAGA----G
Mflv_1550|M.gilvum_PYR-GCK ARFGDDGLQQQWAAPAVTG--DKVLTVALDGEMGEGPVRATTTAD----G
Mvan_5207|M.vanbaalenii_PYR-1 ATFGSASLQQDWAAQAIKG--EKVLAVAFDGEMGEGPVLAQGSGD----G
MSMEG_5907|M.smegmatis_MC2_155 AEFGSDAQRAEWGAPAVAG--SKILTVALDGEMGQGPVQAQADGD----D
MAB_4159|M.abscessus_ATCC_1997 AAFGSEAMRNDWAAPAVAG--KKVLTIALEGEPGEGPVAARTEGT----G
TH_3575|M.thermoresistible__bu AEFGSDAQREQWAAPAVGG--QRILTAALEGETGEGPVRAEVNADS---G
MLBr_00661|M.leprae_Br4923 TYWGSADQQATYLKEFTGENVPQACVAIAEPQPLFDPTRLKTIAVRTPSG
: :* : : : . : : .*. . .
MUL_4068|M.ulcerans_Agy99 FRLTGTRTQVGYGPVADAFLVPAETDSGTVVFLVAADDPGVSVTALQTTG
MMAR_4993|M.marinum_M FRLTGTRTQVGYGPVADAFLVPAETDSGTVVFLVAADDPGVSVTALQTTG
Mb3535|M.bovis_AF2122/97 YRLTGTRTQVGYGPVADAFLVPAETDSGAAVFLVAAGDPGVAVTALATTG
Rv3505|M.tuberculosis_H37Rv YRLTGTRTQVGYGPVADAFLVPAETDSGAAVFLVAAGDPGVAVTALATTG
MAV_0651|M.avium_104 YRLTGTRTQVGFGPVADAFLVPAETDSGTAVFLVAADDPGVTVTALETTG
Mflv_1550|M.gilvum_PYR-GCK VTLTGTRTQVPFAVGADAFLVPAETDSGVAVFLVAAADAGVTVTPLDTTG
Mvan_5207|M.vanbaalenii_PYR-1 YTLTGSRTQVAFGVNADAFLVPAETDSGTAVFLVGSADDGVAVTALDTTG
MSMEG_5907|M.smegmatis_MC2_155 HRLTGSRTLVSYGPVADAYLVPAETGSGVSVFIVAADDAGVTETSLNTTG
MAB_4159|M.abscessus_ATCC_1997 YVLTGNRVLVPFGVEADAYLVPAETETGTAVFLVSADDAGVTQQALHTTG
TH_3575|M.thermoresistible__bu HTLTGTRTLVRFGPVADGFLVPAETDSGTRVFLVAADDPGVTVTALNTTG
MLBr_00661|M.leprae_Br4923 YRLDGVKSLVPAAASAELFIIGAQLNGKPALFIVESSTKGLTVKADPSMG
* * : * . *: ::: *: :*:* : *:: . : *
MUL_4068|M.ulcerans_Agy99 L--GSVGHLALDGTEVDAARGIG---GSD-VTAWLRTINTLGRSAFQLGV
MMAR_4993|M.marinum_M L--GSVGHLALDGTEVDAARGIG---GSD-VTAWLRTINTLGRSAFQLGV
Mb3535|M.bovis_AF2122/97 L--GSVGHLELNGAKVDAARRVG---GTD-VVVWLGTLSTLSRTAFQLGV
Rv3505|M.tuberculosis_H37Rv L--GSVGHLELNGAKVDAARRVG---GTD-VAVWLGTLSTLSRTAFQLGV
MAV_0651|M.avium_104 L--GSVGHLALDGTQVDGTRQVG---GAE-VAAWLGTLGTLGRAAFQLGV
Mflv_1550|M.gilvum_PYR-GCK H--GSVAALDLQGVGITGDRRVG---GSE-VLDWLVTRNALARSAYQLGV
Mvan_5207|M.vanbaalenii_PYR-1 H--GSVAGLQLQGVAIGSDRRVG---GPE-VLDWLVTRHALGRSAYQLGV
MSMEG_5907|M.smegmatis_MC2_155 K--GSVAHLDLQDVAVGADRVLG---GTQ-VAEWLTTRVTLGRTAYQLGV
MAB_4159|M.abscessus_ATCC_1997 K--DSSAELILSEVPVPAERKVG---GAE-VVEWLRLRESLGHSAYQLGV
TH_3575|M.thermoresistible__bu R--GSVGRLELAGTVLPPDRTVG---ADEAALRWIKIRNILGHSAFQLGV
MLBr_00661|M.leprae_Br4923 IRAAALGQVELCGVSAPLDARLGEDDATDNDYSEAIALARLGWAALAVGT
: . : * . :* . : *. :* :*.
MUL_4068|M.ulcerans_Agy99 LERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAA
MMAR_4993|M.marinum_M LERGLRMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAA
Mb3535|M.bovis_AF2122/97 LERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAA
Rv3505|M.tuberculosis_H37Rv LERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAA
MAV_0651|M.avium_104 LERGLQMTAEYARTREQFDRPIGSFQAVSQRLADGYIDVKGLRLTLTQAA
Mflv_1550|M.gilvum_PYR-GCK VERALELTAQYAREREQFDRPIGSFQAVSSRLADGYIDIKGLRLTVTQAA
Mvan_5207|M.vanbaalenii_PYR-1 LERALELTASYAREREQFDRPIGSFQAVSSRLADGYIDIKGLRLTLTQAA
MSMEG_5907|M.smegmatis_MC2_155 LERALELTASYAREREQFDRPIGSFQAVSSRLADGYIDVKGLRLTLTQAA
MAB_4159|M.abscessus_ATCC_1997 LERALELTADYARTREQFGKPIGGFQAVAQRLADGYIDVKGLCLTLWQAA
TH_3575|M.thermoresistible__bu LERALEMTAAYAREREQFDRPLX---XXAGGCAGGGVPAG----------
MLBr_00661|M.leprae_Br4923 SHAVLDYVMPYVKEREAFGEPIARRQAVAFMCANIAIELDGLRLITWRGA
. * . *.: ** *..*: . *. :
MUL_4068|M.ulcerans_Agy99 WRVSED--------LPAEIDVASAGFCAAEAGHRVAHTIVHVHGGVGVDT
MMAR_4993|M.marinum_M WRVSED--------LPAEIDVASAGFWAAEAGHRVAHTIVHVHGGVGVDT
Mb3535|M.bovis_AF2122/97 WRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDT
Rv3505|M.tuberculosis_H37Rv WRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDT
MAV_0651|M.avium_104 WRVSED--------LPAEVDVATAAFWAADAGHRVAHTIVHVHGGVGVDT
Mflv_1550|M.gilvum_PYR-GCK WRVSED--------LPADVDVASAAFWAAEAGHRVAHTAVHVHGGVGIDI
Mvan_5207|M.vanbaalenii_PYR-1 WRLSED--------LPADLDVASAAFWAAEAGHRVAHTTVHVHGGVGIDI
MSMEG_5907|M.smegmatis_MC2_155 WRLSED--------LPADVDVASAAFWAAEAGHRVAHTAVHVHGGVGIDM
MAB_4159|M.abscessus_ATCC_1997 WRVSED--------LPSDVDVATAKFWAADAGHRVAHTAVHVHGGVGIDE
TH_3575|M.thermoresistible__bu --------------RPGHRGAAVGGGRAGPSG-RTAHPGRPGH-------
MLBr_00661|M.leprae_Br4923 SRAEQG--------LSFAREAALAKRLGSDKAMQIGLDGVQLLGGHGFIK
. .* . .. . : .
MUL_4068|M.ulcerans_Agy99 DHPVHRYFLAAKEAEFALGGATTALRQIGRELAETPA
MMAR_4993|M.marinum_M DHPVHRYFLAAKEAEFALGGATTALRQIGRELAETPA
Mb3535|M.bovis_AF2122/97 DHPVHRYFLAAKQTEFALGGATGQLRRIGRELAETPA
Rv3505|M.tuberculosis_H37Rv DHPVHRYFLAAKQTEFALGGATGQLRRIGRELAETPA
MAV_0651|M.avium_104 DHPVHRYFLAAKQAEFALGGATGQLRRIGRELAETPA
Mflv_1550|M.gilvum_PYR-GCK DHPVHRYFLAAKQTEFAVGGATGQLLRIGRELADTPA
Mvan_5207|M.vanbaalenii_PYR-1 DHPVHRYFLAAKQTEFAVGGATGQLLRIGRELADTPA
MSMEG_5907|M.smegmatis_MC2_155 DHPVHRYFLAAKQSEFALGSATGQLLRIGRELADTPV
MAB_4159|M.abscessus_ATCC_1997 DHPVHRYFLAAKRGEFASGSATEQLRRIGRELADTPA
TH_3575|M.thermoresistible__bu ---LRRRARDGVQDAAGRCADGGGARRW---------
MLBr_00661|M.leprae_Br4923 EHPVERWYRDLR----AIGVAEGVVVI----------
:.* .