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REFGNPLGDRPPLDELARTDLLLDALAEREEVDFADPRDDALAALLGQWRDDLRWPPASALVSQDEAVAA LRAGVAQRRRARRSLAAVGSVAAALLVLSGFGAVVADARPGDLLYGLHAMMFNRSRVSDDQIVLSAKANL AKVEQMIAQGQWAEAQDELAEVSSTVQAVTDGSRRQDLINEVNLLNTKVETRDPNATLRPGSPSNPAAPG SVGNSWTPLAPVVEPPTPPTPASAAEPSMSAGVSESPMPNSTSTVAASPSTPSSKPEPGSIDPSLEPADE ATNPAGQPAPETPVSPTH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3413c | - | - | 100% (299) | HYPOTHETICAL ALANINE AND PROLINE RICH PROTEIN |
| M. tuberculosis H37Rv | Rv3879c | - | 1e-07 | 30.36% (112) | hypothetical protein Rv3879c |
| M. tuberculosis H37Rv | Rv3903c | - | 3e-06 | 31.54% (130) | hypothetical protein Rv3903c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3447c | - | 1e-169 | 100.00% (299) | hypothetical protein Mb3447c |
| M. gilvum PYR-GCK | Mflv_4911 | - | 1e-46 | 38.71% (310) | hypothetical protein Mflv_4911 |
| M. leprae Br4923 | MLBr_01506 | - | 3e-05 | 31.73% (104) | hypothetical protein MLBr_01506 |
| M. abscessus ATCC 19977 | MAB_3723c | - | 7e-32 | 31.25% (288) | hypothetical protein MAB_3723c |
| M. marinum M | MMAR_1135 | - | 9e-91 | 58.22% (304) | hypothetical protein MMAR_1135 |
| M. avium 104 | MAV_4358 | - | 1e-64 | 49.14% (291) | hypothetical protein MAV_4358 |
| M. smegmatis MC2 155 | MSMEG_1600 | - | 2e-47 | 36.87% (339) | hypothetical protein MSMEG_1600 |
| M. thermoresistible (build 8) | TH_3373 | - | 1e-47 | 39.19% (296) | PUTATIVE hypothetical protein Mjls_1192 |
| M. ulcerans Agy99 | MUL_0898 | - | 1e-91 | 57.56% (311) | hypothetical protein MUL_0898 |
| M. vanbaalenii PYR-1 | Mvan_1509 | - | 2e-48 | 38.41% (302) | hypothetical protein Mvan_1509 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3413c|M.tuberculosis_H37Rv -------MREFGNPL-------GDRPPLDELARTDLLLDALAEREEVD--
Mb3447c|M.bovis_AF2122/97 -------MREFGNPL-------GDRPPLDELARTDLLLDALAEREEVD--
MMAR_1135|M.marinum_M -------MPESGFAL-------GDQPGLDEVARTDLLLDALAGRERFS--
MUL_0898|M.ulcerans_Agy99 -------MPESGFTL-------GDQPGLDEVARTDLLLDALAGRERFS--
MAV_4358|M.avium_104 --------------M-------TVPESLDEFARTDLLLDALAQRRPVPRG
Mflv_4911|M.gilvum_PYR-GCK -------MPDFGRRD-----PGGGDPSLTDINRTDQFLDALAAQQQPF--
Mvan_1509|M.vanbaalenii_PYR-1 -------MPDHGRWN-----SGG-DPSLNEINRTDQFLDALASQQPVY--
TH_3373|M.thermoresistible__bu -------MADFGRWNPNWNPDDGGQPSLQDIHRSEQFIEALSTGRPVY--
MSMEG_1600|M.smegmatis_MC2_155 -------MPDFGRWT-----SNGGDPSLNEINRTDRFIEALSLEQPVY--
MAB_3723c|M.abscessus_ATCC_199 MADGRGWFPGQGGWQ-----ENEGPEDLAALRRTNRMIDAIAADLPVA--
MLBr_01506|M.leprae_Br4923 -------MKTGGFVTS----AWNLPKGLVAVVTASTAAFGLCQNAAAD--
* . :. .:.
Rv3413c|M.tuberculosis_H37Rv -FADPRD---DALAALLGQWRDDLRWPPASALVS--QDEAVAALRAGVAQ
Mb3447c|M.bovis_AF2122/97 -FADPRD---DALAALLGQWRDDLRWPPASALVS--QDEAVAALRAGVAQ
MMAR_1135|M.marinum_M -LNDPDD---DALAALMGEWRDDLRWPPASALVS--QNEAVDALILGLSE
MUL_0898|M.ulcerans_Agy99 -LNDPDD---DALAALMGEWRDDLRWPPASALVS--QNEAVDALILGLSE
MAV_4358|M.avium_104 QVEDPDDPDFQMLTTLLEDWRDNLRWPPASALVT--PEEAVNALRAGLAE
Mflv_4911|M.gilvum_PYR-GCK -VTDRDD---VELAQLLAGWRDDIRETPMGHVVT--PLQAEAALDR-VTR
Mvan_1509|M.vanbaalenii_PYR-1 -ATDRGE---AELAHLLAGWRDDVRETPMGHVMT--AEDAAIALGR-VTK
TH_3373|M.thermoresistible__bu -ANDPGE---DELAYLMAGWRDRARNAPMRATIT--EQDAVAALQRGLPR
MSMEG_1600|M.smegmatis_MC2_155 -STDPEE---AELAFLLAGWRDDVRQAPMTGIIN--PREAVVALDRAVAR
MAB_3723c|M.abscessus_ATCC_199 -TSDSDE---YAVAMMLAAWREDVGREPMPAKPT--LGQARNALRDRGGR
MLBr_01506|M.leprae_Br4923 -PANPYG-TPPNPTQQLPGLPALAQLSPIVQQAANNPQQATQLLMEAVSA
: : : * :* *
Rv3413c|M.tuberculosis_H37Rv RR------RARRSLAAVGSVAAALLVLSGFGAVVADARPGDLLYGLHAMM
Mb3447c|M.bovis_AF2122/97 RR------RARRSLAAVGSVAAALLVLSGFGAVVADARPGDLLYGLHAMM
MMAR_1135|M.marinum_M RR------RSRRAWAAIGSVAATLLALSGLGAVVADARPGDLLYGLHAML
MUL_0898|M.ulcerans_Agy99 RR------RSRRAWAAIGSVAATLLALSGLGAVVADARPGDLLYGLHAML
MAV_4358|M.avium_104 RR------RGHRGLAVVGSVAATLMLLSGFGAMVVEARPGSTLYGLHAMF
Mflv_4911|M.gilvum_PYR-GCK PAA----PRRRFSLAVVGSAAAAVLAIGGFGAVVAGSGPGDALYGLRTML
Mvan_1509|M.vanbaalenii_PYR-1 P------PRRRLSLAVIGSAAAAVLAIGGVGAVVAGSGPGDALYGLRTML
TH_3373|M.thermoresistible__bu PRGGAPRPGRRFSLTVVGSAAAAVICLGGFGALVAGAGPGDPLYGLRTML
MSMEG_1600|M.smegmatis_MC2_155 N-------RPRLPLALVGSAAAAVLCLGGFGAAVYGSSPGDALYGLRGMI
MAB_3723c|M.abscessus_ATCC_199 SR---------MLATTVGSAAAVTLLFGGFGAAVYQSHPGDALYGLRTSL
MLBr_01506|M.leprae_Br4923 LT---------QNPTAPIASKNLATSVSQFMQEPNNPNPGASALDIPTSG
: : .. . . ** .:
Rv3413c|M.tuberculosis_H37Rv FNRSRVSD-DQIVLSAKANLAKVEQMIAQGQWAEAQDELAEVSSTVQAVT
Mb3447c|M.bovis_AF2122/97 FNRSRVSD-DQIVLSAKANLAKVEQMIAQGQWAEAQDELAEVSSTVQAVT
MMAR_1135|M.marinum_M FNEPRVSE-DQIMLSAKADLAKAEQMIAQGQWDQAESQLAEVSSTLQTVN
MUL_0898|M.ulcerans_Agy99 FNEPRVSE-DQIMLSAKADLAKAEQMIAQGQWDQAESQLAEVSSTLQTVN
MAV_4358|M.avium_104 FDQPRVNEKDQVMLAAKADLAKVAESIDKGQWDQARTQLTEVSSLVASID
Mflv_4911|M.gilvum_PYR-GCK FGEQVQMRDDAVILAAQTEMQQVQQLIEQGDWQQAQAKLEAVTTTVATVD
Mvan_1509|M.vanbaalenii_PYR-1 FGEQAQTRDDAVILAAQTEMQQVQQLIEQGDWAGAQAKLEAVTTTVATVA
TH_3373|M.thermoresistible__bu FGD--VVRDDPVVLAAQTQLAEVEQLIAQGDWEAAQERLQAVTTTVATVG
MSMEG_1600|M.smegmatis_MC2_155 FGEQ-ATRDVQVELAS-TELEQVQQLIEQGDWQAAQQKLQTLTTTVATVN
MAB_3723c|M.abscessus_ATCC_199 FGAPPAVRTDPVVLSAQTELAQVEKLISQGDWEEAQQQLGVAAARVNEVG
MLBr_01506|M.leprae_Br4923 VPAPAANGITPLDVVLVPHLPSAG--AEPGAQAHLPTGIDPVHAAGPATA
. : : ..: .. * : :
Rv3413c|M.tuberculosis_H37Rv DGSRRQDLINEVNLLNTKVETRDPNATLR----PGSPSNPAA--------
Mb3447c|M.bovis_AF2122/97 DGSRRQDLINEVNLLNTKVETRDPNATLR----PGSPSNPAA--------
MMAR_1135|M.marinum_M DGSRRQHLLNELNQLNTKVEKRDPNATLP----AGGPPQSGP--------
MUL_0898|M.ulcerans_Agy99 DGSRRQHLLNELNQLNTKVEKRDPNATLP----AGGPPQSGP--------
MAV_4358|M.avium_104 DPATKQDLMTQLNLLNAKVDTRNPNATLP----AAAPS------------
Mflv_4911|M.gilvum_PYR-GCK DVAQKEELIAQWQELTVKVEAQDPVATVP----PGAPLPTFPELPAAVLD
Mvan_1509|M.vanbaalenii_PYR-1 DVERKQELVTQWQELTVKVEAQDPVATVP----PGSPLPTFPDVPVAVLD
TH_3373|M.thermoresistible__bu DETRKQELVAEWQELSVKVESRNPDATVP----PDAPPVTLP-----VID
MSMEG_1600|M.smegmatis_MC2_155 DEAQKQQLVTQWQQLSVKVENQDPNATVA----PDAPPPVFPEVTITPPA
MAB_3723c|M.abscessus_ATCC_199 DAQQKAELASRVQQAEVRIDAKDPQATVPPEMVTETPRIMLSPPSIAPIT
MLBr_01506|M.leprae_Br4923 ATPTPGSPTNRTAAPPTPVASPAPTTPELPATTPGFGPDAPP--------
. . : * :. .
Rv3413c|M.tuberculosis_H37Rv --------------------------------PGSVG------NSWTPLA
Mb3447c|M.bovis_AF2122/97 --------------------------------PGSVG------NSWTPLA
MMAR_1135|M.marinum_M --------------------------------TGVLAPQVPPGNSLTPLV
MUL_0898|M.ulcerans_Agy99 --------------------------------TGVLAPQVPPGNSLTPLA
MAV_4358|M.avium_104 ------------------------------------------------MA
Mflv_4911|M.gilvum_PYR-GCK QATTSSETTAGTTSDTTAPSSETTAPSSETTGPSSETTTAP--SETTGPA
Mvan_1509|M.vanbaalenii_PYR-1 PGTSSETTSTAPSSETTSPTS-PSETTSPTSPSETTSPTSP--SETTSPA
TH_3373|M.thermoresistible__bu PATSTEPTEPGTPSTEPAEPGEPTEPGDPDMPVDGTEPTSPGTEPTAGPD
MSMEG_1600|M.smegmatis_MC2_155 P-TDTSAVETTPGSATPSEPTSPGESATPSDTSDTSEPSSE-TTVPSSPT
MAB_3723c|M.abscessus_ATCC_199 STTTTSTTSTTSASTTTSDSTSASTSTTETSGSASPSTSSSTSTSATAST
MLBr_01506|M.leprae_Br4923 -------------------------------TQDFIYPSISTNCLADGSS
Rv3413c|M.tuberculosis_H37Rv PVVEPPTPP--------TPASAAEPSMSAGVSESPMPNSTSTVAASPSTP
Mb3447c|M.bovis_AF2122/97 PVVEPPTPP--------TPASAAEPSMSAGVSESPMPNSTSTVAASPSTP
MMAR_1135|M.marinum_M PETVSPVPPNESGAPESAPAPSASPTTTGAKPSASLPPAGATATSPAPTS
MUL_0898|M.ulcerans_Agy99 PETVSPVPPNESGAPESAPAPSASPTTTGAKPSASLPPAGATATSPAPTS
MAV_4358|M.avium_104 PSVAVPAAP--------PPAASIAP--TPAAPPAPLSP------APVSTP
Mflv_4911|M.gilvum_PYR-GCK PTTTAPTSAPTTT--APAPSTTP-TTSVGQTR-SSAAPSTPPSSAPTSTT
Mvan_1509|M.vanbaalenii_PYR-1 PSSETTSAPTSSP--SPTPSTAPTTTSVGAAPPSSSAPATTTPTSTTATR
TH_3373|M.thermoresistible__bu QPTVPPTVGPTSEPATSEPAMTAPTTTVPTSAPGSAVRTTTSAPTTATTT
MSMEG_1600|M.smegmatis_MC2_155 PSTAPSSSVPTAT--SQTPTSTQVPTSTPTSSAAVQLPSPVEEEEPAEPQ
MAB_3723c|M.abscessus_ATCC_199 SVTSVPTSTPTTVTITTTPPSSAATITSTPASATETTTAPSVSTAPTTSV
MLBr_01506|M.leprae_Br4923 SIATALSVAGPAKIPLPGPGPGQAAYVFTAVGTPGPADVQKLPLNVTWVN
* .
Rv3413c|M.tuberculosis_H37Rv SSKPEPGSIDPSLEPADEATNPAGQPAPETPVSPTH--------------
Mb3447c|M.bovis_AF2122/97 SSKPEPGSIDPSLEPADEATNPAGQPAPETPVSPTH--------------
MMAR_1135|M.marinum_M VPTPPVSAVVPGETPADTSVVAPGSPAAAGVAATGAG-------------
MUL_0898|M.ulcerans_Agy99 VPTPPVSAVVPGETPADTSVVAPGSPAAAGVAAPGPAKLAAPGDATNPGS
MAV_4358|M.avium_104 SPSPSVG-----------KHHHHGQPPAVAPVNPNQ--------------
Mflv_4911|M.gilvum_PYR-GCK VVLQSTTTSAAAPTTSAAPTTAAPTTAAPTTAVPTTPSAVETTPAVEEET
Mvan_1509|M.vanbaalenii_PYR-1 APSATSTTVVQSATTTSAPLSTSSSVAAPPTPTPSPSPTPTPAPTVDEES
TH_3373|M.thermoresistible__bu SGSTTAGPTAGGPTSSGPATGPTSVPREPGAGAGTTEPTAPAARAGEDGV
MSMEG_1600|M.smegmatis_MC2_155 PTSVPQAPTS-APAVPAEPSGPSGDPARPPVTATTTVTLPTQAGPAQGPN
MAB_3723c|M.abscessus_ATCC_199 PGVTASTTVPPTASIVTVPTTPEGVTIVTTRPGVVNTPVITAPTTIEAPV
MLBr_01506|M.leprae_Br4923 LTTGKSGSATLKPRPDINPEGPTTLTVIADTGSGSIMSTIFG--------
Rv3413c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3447c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1135|M.marinum_M --------------------------------------------------
MUL_0898|M.ulcerans_Agy99 PVVQTSGQPEPVEPAPAGPVS-----------------------------
MAV_4358|M.avium_104 --------------------------------------------------
Mflv_4911|M.gilvum_PYR-GCK ------------PPSPVAPVTTTTP----VLPLPGE--------------
Mvan_1509|M.vanbaalenii_PYR-1 ------------VPSPTAPALPTTTTPIILLPVPGEAG------------
TH_3373|M.thermoresistible__bu GGDGTVGGDGAFAEETVGEVPQLTATTTVVLPQSGAADAAGD--------
MSMEG_1600|M.smegmatis_MC2_155 GRGNGPGNGAKPAEPAQPKAPEQPAVQIPLLPGMGGN-------------
MAB_3723c|M.abscessus_ATCC_199 PITRTPDNPAPAYQAPVNSPGSGNLHGYPGSGGNAGSGSDGPSRHMPAMT
MLBr_01506|M.leprae_Br4923 -----------QVTTKEKQCQFMPTIGSTVVP------------------
Rv3413c|M.tuberculosis_H37Rv --------------------------
Mb3447c|M.bovis_AF2122/97 --------------------------
MMAR_1135|M.marinum_M --------------------------
MUL_0898|M.ulcerans_Agy99 --------------------------
MAV_4358|M.avium_104 --------------------------
Mflv_4911|M.gilvum_PYR-GCK --------------------------
Mvan_1509|M.vanbaalenii_PYR-1 --------------------------
TH_3373|M.thermoresistible__bu --------------------------
MSMEG_1600|M.smegmatis_MC2_155 --------------------------
MAB_3723c|M.abscessus_ATCC_199 SVPVAPANPGSGSANQGSGSGSHTDE
MLBr_01506|M.leprae_Br4923 --------------------------