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EFPVLPPEINSVLMYSGAGSSPLLAAAAAWDGLAEELGSAAVSFGQVTSGLTAGVWQGAAAAAMAAAAAP YAGWLGSVAAAAEAVAGQARVVVGVFEAALAATVDPALVAANRARLVALAVSNLLGQNTPAIAAAEAEYE LMWAADVAAMAGYHSGASAAAAALPAFSPPAQALGGGVGAFLTALFASPAKALSLNAGLGNVGNYNVGLG NVGVFNLGAGNVGGQNLGFGNAGGTNVGFGNLGNGNVGFGNSGLGAGLAGLGNIGLGNAGSSNYGFANLG VGNIGFGNTGTNNVGVGLTGNHLTGIGGLNSGTGNIGLFNSGTGNVGFFNSGTGNFGVFNSGNYNTGVGN AGTASTGLFNAGNFNTGVVNVGSYNTGSFNAGDTNTGGFNPGGVNTGWLNTGNTNTGIANSGNVNTGAFI SGNFNNGVLWVGDYQGLFGVSAGSSIPAIPIGLVLNGDIGPITIQPIPILPTIPLSIHQTVNLGPLVVPD IVIPAFGGGIGIPINIGPLTITPITLFAQQTFVNQLPFPTFSLGKITIPQIQTFDSNGQLVSFIGPIVID TTIPGPTNPQIDLTIRWDTPPITLFPNGISAPDNPLGLLVSVSISNPGFTIPGFSVPAQPLPLSIDIEGQ IDGFSTPPITIDRIPLTVGGGVTIGPITIQGLHIPAAPGVGNTTTAPSSGFFNSGAGGVSGFGNVGAGSS GWWNQAPSALLGAGSGVGNVGTLGSGVLNLGSGISGFYNTSVLPFGTPAAVSGIGNLGQQLSGVSAAGTT LRSMLAGNLGLANVGNFNTGFGNVGDVNLGAANIGGHNLGLGNVGDGNLGLGNIGHGNLGFANLGLTAGA AGVGNVGFGNAGINNYGLANMGVGNIGFANTGTGNIGIGLVGDHRTGIGGLNSGIGNIGLFNSGTGNVGF FNSGTGNFGIGNSGRFNTGIGNSGTASTGLFNAGSFSTGIANTGDYNTGSFNAGDTNTGGFNPGGINTGW FNTGHANTGLANAGTFGTGAFMTGDYSNGLLWRGGYEGLVGVRVGPTISQFPVTVHAIGGVGPLHVAPVP VPAVHVEITDATVGLGPFTVPPISIPSLPIASITGSVDLAANTISPIRALDPLAGSIGLFLEPFRLSDPF ITIDAFQVVAGVLFLENIIVPGLTVSGQILVTPTPIPLTLNLDTTPWTLFPNGFTIPAQTPVTVGMEVAN DGFTFFPGGLTFPRASAGVTGLSVGLDAFTLLPDGFTLDTVPATFDGTILIGDIPIPIIDVPAVPGFGNT TTAPSSGFFNTGGGGGSGFANVGAGTSGWWNQGHDVLAGAGSGVANAGTLSSGVLNVGSGISGWYNTSTL GAGTPAVVSGIGNLGQQLSGFLANGTVLNRSPIVNIGWADVGAFNTGLGNVGDLNWGAANIGAQNLGLGN LGSGNVGFGNIGAGNVGFANSGPAVGLAGLGNVGLSNAGSNNWGLANLGVGNIGLANTGTGNIGIGLVGD YQTGIGGLNSGSGNIGLFNSGTGNVGFFNTGTGNFGLFNSGSFNTGIGNSGTGSTGLFNAGNFNTGIANP GSYNTGSFNVGDTNTGGFNPGDINTGWFNTGIMNTGTRNTGALMSGTDSNGMLWRGDHEGLFGLSYGITI PQFPIRITTTGGIGPIVIPDTTILPPLHLQITGDADYSFTVPDIPIPAIHIGINGVVTVGFTAPEATLLS ALKNNGSFISFGPITLSNIDIPPMDFTLGLPVLGPITGQLGPIHLEPIVVAGIGVPLEIEPIPLDAISLS ESIPIRIPVDIPASVIDGISMSEVVPIDASVDIPAVTITGTTISAIPLGFDIRTSAGPLNIPIIDIPAAP GFGNSTQMPSSGFFNTGAGGGSGIGNLGAGVSGLLNQAGAGSLVGTLSGLGNAGTLASGVLNSGTAISGL FNVSTLDATTPAVISGFSNLGDHMSGVSIDGLIAILTFPPAESVFDQIIDAAIAELQHLDIGNALALGNV GGVNLGLANVGEFNLGAGNVGNINVGAGNLGGSNLGLGNVGTGNLGFGNIGAGNFGFGNAGLTAGAGGLG NVGLGNAGSGSWGLANVGVGNIGLANTGTGNIGIGLTGDYRTGIGGLNSGTGNLGLFNSGTGNIGFFNTG TGNFGLFNSGSYSTGVGNAGTASTGLFNAGNFNTGLANAGSYNTGSLNVGSFNTGGVNPGTVNTGWFNTG HTNTGLFNTGNVNTGAFNSGSFNNGALWTGDYHGLVGFSFSIDIAGSTLLDLNETLNLGPIHIEQIDIPG MSLFDVHEIVEIGPFTIPQVDVPAIPLEIHESIHMDPIVLVPATTIPAQTRTIPLDIPASPGSTMTLPLI SMRFEGEDWILGSTAAIPNFGDPFPAPTQGITIHTGPGPGTTGELKISIPGFEIPQIATTRFLLDVNISG GLPAFTLFAGGLTIPTNAIPLTIDASGALDPITIFPGGYTIDPLPLHLALNLTVPDSSIPIIDVPPTPGF GNTTATPSSGFFNSGAGGVSGFGNVGSNLSGWWNQAASALAGSGSGVLNVGTLGSGVLNVGSGVSGIYNT SVLPLGTPAVLSGLGNVGHQLSGVSAAGTALNQIPILNIGLADVGNFNVGFGNVGDVNLGAANLGAQNLG LGNVGTGNLGFANVGHGNIGFGNSGLTAGAAGLGNTGFGNAGSANYGFANQGVRNIGLANTGTGNIGIGL VGDNLTGIGGLNSGAGNIGLFNSGTGNIGFFNSGTGNFGIGNSGSFNTGIGNSGTGSTGLFNAGSFNTGV ANAGSYNTGSFNAGDTNTGGFNPGTINTGWFNTGHTNTGIANSGNVGTGAFMSGNFSNGLLWRGDHEGLF SLFYSLDVPRITIVDAHLDGGFGPVVLPPIPVPAVNAHLTGNVAMGAFTIPQIDIPALTPNITGSAAFRI VVGSVRIPPVSVIVEQIINASVGAEMRIDPFEMWTQGTNGLGITFYSFGSADGSPYATGPLVFGAGTSDG SHLTISASSGAFTTPQLETGPITLGFQVPGSVNAITLFPGGLTFPATSLLNLDVTAGAGGVDIPAITWPE IAASADGSVYVLASSIPLINIPPTPGIGNSTITPSSGFFNAGAGGGSGFGNFGAGTSGWWNQAHTALAGA GSGFANVGTLHSGVLNLGSGVSGIYNTSTLGVGTPALVSGLGNVGHQLSGLLSGGSAVNPVTVLNIGLAN VGSHNAGFGNVGEVNLGAANLGAHNLGFGNIGAGNLGFGNIGHGNVGVGNSGLTAGVPGLGNVGLGNAGG NNWGLANVGVGNIGLANTGTGNIGIGLTGDYQTGIGGLNSGAGNLGLFNSGAGNVGFFNTGTGNFGLFNS GSFNTGVGNSGTGSTGLFNAGSFNTGVANAGSYNTGSFNVGDTNTGGFNPGSINTGWLNAGNANTGVANA GNVNTGAFVTGNFSNGILWRGDYQGLAGFAVGYTLPLFPAVGADVSGGIGPITVLPPIHIPPIPVGFAAV GGIGPIAIPDISVPSIHLGLDPAVHVGSITVNPITVRTPPVLVSYSQGAVTSTSGPTSEIWVKPSFFPGI RIAPSSGGGATSTQGAYFVGPISIPSGTVTFPGFTIPLDPIDIGLPVSLTIPGFTIPGGTLIPTLPLGLA LSNGIPPVDIPAIVLDRILLDLHADTTIGPINVPIAGFGGAPGFGNSTTLPSSGFFNTGAGGGSGFSNTG AGMSGLLNAMSDPLLGSASGFANFGTQLSGILNRGAGISGVYNTGALGVVTAAVVSGFGNVGQQLSGLLF TGVGP*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv3350c | PPE56 | - | 100% (3716) | PPE FAMILY PROTEIN |
M. tuberculosis H37Rv | Rv3347c | PPE55 | 0.0 | 67.17% (3019) | PPE family protein |
M. tuberculosis H37Rv | Rv3343c | PPE54 | 0.0 | 44.62% (2530) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3380c | PPE55a | 0.0 | 64.35% (1902) | hypothetical protein Mb3380c |
M. gilvum PYR-GCK | Mflv_0325 | - | 4e-26 | 36.08% (194) | PPE protein |
M. leprae Br4923 | MLBr_01182 | - | 3e-32 | 44.71% (170) | PPE-family protein |
M. abscessus ATCC 19977 | MAB_0669 | - | 1e-25 | 36.05% (172) | PPE-family protein |
M. marinum M | MMAR_4621 | - | 0.0 | 37.64% (3746) | PPE family protein |
M. avium 104 | MAV_4704 | - | 7e-54 | 57.21% (201) | PPE family protein |
M. smegmatis MC2 155 | MSMEG_0868 | - | 2e-28 | 28.27% (902) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3113 | - | 1e-29 | 40.41% (193) | PUTATIVE PPE protein |
M. ulcerans Agy99 | MUL_0782 | - | 1e-136 | 55.39% (464) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-27 | 36.32% (201) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGP---------------G Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGP---------------G MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGP---------------G TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGP---------------G MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGS---------------S Rv3350c|M.tuberculosis_H37Rv -------------MEFPVLPPEINSVLMYSGAGS---------------S Mb3380c|M.bovis_AF2122/97 -------------MNFPVLPPEINSVLMYSGAGS---------------S MAV_4704|M.avium_104 ----------MTNPHFAWLPPEVNSALIYSGPGP---------------G MMAR_4621|M.marinum_M -------------MSFSVSPPEINSARIFSGAGS---------------G MUL_0782|M.ulcerans_Agy99 -------------MNFSVLPPEVNSALIFTGPGA---------------E MSMEG_0868|M.smegmatis_MC2_155 -----------MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRK . ... . *. Mflv_0325|M.gilvum_PYR-GCK SLLAAGVAWQSLSAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPY Mvan_0415|M.vanbaalenii_PYR-1 SMLAAAATWQSLSAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPY MAB_0669|M.abscessus_ATCC_1997 AVLAAAVQWQEIGNNYANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPY TH_3113|M.thermoresistible__bu ALSAAADAWRMLSDEYRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPY MLBr_01182|M.leprae_Br4923 PILTAAAAWVVLAKELTAAAQGLQSAVEALLT-TFEGESAAALAERVTPY Rv3350c|M.tuberculosis_H37Rv PLLAAAAAWDGLAEELGSAAVSFGQVTSGLTAGVWQGAAAAAMAAAAAPY Mb3380c|M.bovis_AF2122/97 PLLAAAAAWDGLAEELGSAAVSFGQVTSGLTAGVWQGAAAAAMAAAAAPY MAV_4704|M.avium_104 PLLAAAAAWDGLAEELASSAQSFSSVTSDLASGSWQGASSAAMMTVANQY MMAR_4621|M.marinum_M PLLSAAAAWDGLAGELGSAAATFSSVTSALTGSSWQGPASAAMANVASGY MUL_0782|M.ulcerans_Agy99 PMRTAATAWGGMAVELESAADSFASVTSGLVGGAWQGASSVAMGTAAASY MSMEG_0868|M.smegmatis_MC2_155 PKFPAALAPESPLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQ . .*. : : . Mflv_0325|M.gilvum_PYR-GCK LAWLAQQSAVSAATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVG Mvan_0415|M.vanbaalenii_PYR-1 LAWLAQQSAAGAAAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVA MAB_0669|M.abscessus_ATCC_1997 LAWLEQAAAESSVIAAQHETTAAAYNSALAAMPTLAELAANHITHGVLVG TH_3113|M.thermoresistible__bu LFWLTDTAAAAAAAGAQLEAAAAAHASALAAMPTMAELTANRTTHAALVA MLBr_01182|M.leprae_Br4923 EKWLTQNAASAELTATQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIM Rv3350c|M.tuberculosis_H37Rv AGWLGSVAAAAEAVAGQARVVVGVFEAALAATVDPALVAANRARLVALAV Mb3380c|M.bovis_AF2122/97 AGWLGSVAAQAVAVAGQARAAVAAFEAALAATVDPAAVAVNRMAMRALAM MAV_4704|M.avium_104 VSWLSAAAAQAEEVSHQASAIATAFEVALAATVQPAVVAANRALVQALAA MMAR_4621|M.marinum_M LGWLASTGVQAGQAASQARIAAAAFEATVAATVHPVAVLANRTQLVSLVT MUL_0782|M.ulcerans_Agy99 LGWLNAAAAHAEQAAAQAEALVAEFAAAQSAMVQPFLLAANRSSLVSLVL MSMEG_0868|M.smegmatis_MC2_155 ATSTNTTDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSV . : * Mflv_0325|M.gilvum_PYR-GCK TNFLGINTIPIALNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAP Mvan_0415|M.vanbaalenii_PYR-1 TNFLGINTIPIAMTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAP MAB_0669|M.abscessus_ATCC_1997 TNFFGINTIPIALNEADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPP TH_3113|M.thermoresistible__bu TNFFGVNTIPIAVNEADYARMWIQAATTMATYEAVASAAVSATPRTVAPP MLBr_01182|M.leprae_Br4923 SNIFGQNSTAIAEKEAEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPP Rv3350c|M.tuberculosis_H37Rv SNLLGQNTPAIAAAEAEYELMWAADVAAMAGYHSGASAAAAALPAFSPPA Mb3380c|M.bovis_AF2122/97 SNLLGQNAAAIAAVEAEYELMWAADVAAMAGYHSGASAAAAALPAFSPPA MAV_4704|M.avium_104 TNWLGQNTPAIADIEAAYEQMWASDVAAMFGYHADASAAVAKLPPWNEVL MMAR_4621|M.marinum_M SNLLGFNAPAIATVEAEYEQMWAQDVAAMFGYHTGASAAVAALTPFTQVL MUL_0782|M.ulcerans_Agy99 SNLFGQNAPAIEAVEAEYEQMWALDVSTMATYHAGASAAAASLTPLAQPL MSMEG_0868|M.smegmatis_MC2_155 VTLGTTLIPNAPTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLP . * :* . : Mflv_0325|M.gilvum_PYR-GCK SVLLPGVGEAGRAAADMSAFAAQPMAAQAGAAFDVSNI------------ Mvan_0415|M.vanbaalenii_PYR-1 FVLAPGVGEAGRAAADVTAFAAQAQAAEAGSALDLSNI------------ MAB_0669|M.abscessus_ATCC_1997 AILSPG-GEARSDQSDVPGSPDQIMKMLQG-------------------- TH_3113|M.thermoresistible__bu PILGAGTGESATAAITGAHVTAELRAAESRTLLDEIN------------- MLBr_01182|M.leprae_Br4923 LGVNEVGLAQEVVEEVVEEVVEEVVEAEQA-------------------- Rv3350c|M.tuberculosis_H37Rv QALGGGVGAFLTALFASPAKALSLNAGLGNVGNYNVGLGNVGVFNLGAGN Mb3380c|M.bovis_AF2122/97 QALGGGVGAFLNAIFAGPAKMLRLNAGLGNVGNYNVGLGNVGIFNLGAAN MAV_4704|M.avium_104 QNLG----------FSNASTAVTRPAGSGAVARGYTSR-IAGFLAPRAPQ MMAR_4621|M.marinum_M QSPAAAAAAVQTAIIDFPGRTNIFNAGLGNLGVGNVGFASVGDGNVGGGN MUL_0782|M.ulcerans_Agy99 QN-----------LSELPGR------------------------------ MSMEG_0868|M.smegmatis_MC2_155 VPTVASAVLDPTQIVNWLIYQPLHAAGQQFWVVSPIGS------------ Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv VGGQNLGFGNAGGTNVGFGNLGNGNVG---FGNSGLGAGLAGLGNIGLGN Mb3380c|M.bovis_AF2122/97 VGAQNLGAANAGSGNFGFGNIGNANFG---FGNSGLGL-PPGMGNIGLGN MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M LGDGNVGFGNVGGLNFGSGNWGGFNLGSGNIGSYNFGPGNLGSYNIGFGN MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv AGSSNYGFANLGVGNIGFGNTGTNNVGVGLTGNHLTGIGGLNSGTGNIGL Mb3380c|M.bovis_AF2122/97 AGSSNYGLANLGVGNIGFANTGSNNIGIGLTGDNLTGIGGLNSGTGNLGL MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M AGDYNVGFGNSGLGNIGFGNSGSNNLGIGLTGSGQVGFGGWNSGSGNVGL MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv FNSGTGNVGFFNSGTGNFGVFNSGNYNTGVGNAGTASTGLFNAGNFNTGV Mb3380c|M.bovis_AF2122/97 FNSGTGNIGFFNSGTGNFGVFNSGSYNTGVGNAGTASTGLFNVGGFNTGV MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M FNSGVGNVGLFNSGTGNWGVGNSGEFDTGLFNAGRYNTGVFNSGVLNTGV MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK ----------------------------------------IADIIRLYGE Mvan_0415|M.vanbaalenii_PYR-1 ----------------------------------------IADLIRAYGE MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------E MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv VNVGSYNTGSFNAGDTNTGGFNPGGVNTGWLNTGNTNTGIANSGNVNTGA Mb3380c|M.bovis_AF2122/97 ANVGSYNTGSFNAGNTNTGGFNPGNVNTGWLNTGNTNTGIANSGNVNTGA MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GNAGDYNSGSFNTGASNTGDLNAGDTNTGWANTGNLNTGFGNSGHLNTGG MUL_0782|M.ulcerans_Agy99 -----------------------------------VIAAFGN-------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK VLRFLFEPIFNFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAV Mvan_0415|M.vanbaalenii_PYR-1 LLRFLFEPIFDFLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAV MAB_0669|M.abscessus_ATCC_1997 -FQQWFEKMG--FNPATSAVLAVIMLFLYD-----LLWYPYYAS------ TH_3113|M.thermoresistible__bu LIDRLFAPLFP-PGFADALPDGLLGTLLAPLLPGATGDGPPMATIMSFLL MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv FISGNFNNGVLWVGDYQGLFGVSAGSSIPAIPIGLVLNGDIGPITIQPIP Mb3380c|M.bovis_AF2122/97 FISGNFSNGVLWRGDYEGLWGLSGGSTIPAIPIGLELNGGVGPITVLPIQ MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M FNQGSQNNGFFWRGDAQGQIGFDYTITIPEIGLGLNVDVPLNIPLRGTIG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 --------------TLGGVINTISGQYLIGNGINGTADNPNGGTG----- Mflv_0325|M.gilvum_PYR-GCK SWVGASILYPSLFLLPLLATTLAIVAGVG--------------------- Mvan_0415|M.vanbaalenii_PYR-1 SWVGASILYPSLLLLPLVATTLAIVLGVG--------------------- MAB_0669|M.abscessus_ATCC_1997 ------------YLLPFLIPALSGLSGL---------------------- TH_3113|M.thermoresistible__bu MGLSNPAYLFPVLVYLLFTGVVHTTVAVS--------------------- MLBr_01182|M.leprae_Br4923 -----------------ISQAALDQAVNE--------------------- Rv3350c|M.tuberculosis_H37Rv ILPTIPLSIHQTVNLGPLVVPDIVIPAFG-GGIGIPINIGPLTITPITLF Mb3380c|M.bovis_AF2122/97 ILPTIPLNIHQTFSLGPLVVPDIVIPAFG-GGTAIPISVGPITISPITLF MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M TL---------IDGEPIISVPGFTIPALHLDGTALSGTIGPIVVDPITIT MUL_0782|M.ulcerans_Agy99 -------------GAPATTVT-AAVTALR--------------------- MSMEG_0868|M.smegmatis_MC2_155 ----------------GLLFGDGGHGYDG--------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv AQQTFVNQLPF-PTFSLGKITIPQIQTFDSNGQLVSFIGPIVIDTTIPGP Mb3380c|M.bovis_AF2122/97 PAQNFNTTFPVGPFFGLGVVNISGIEIKDLAGNVTLQLGNLNIDTRIN-- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GPQVDLMVGGPGESLQL--------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv TNPQIDLTIRWDTPPITLFPNGISAPDNPLGLLVSVSISNPGFTIPGFSV Mb3380c|M.bovis_AF2122/97 --QSFPVTVNWSTPAVTIFPNGISIPNNPLALLASASIGTLGFTIPGFTI MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv PAQPLPLSIDIEGQIDGFSTPPITIDRIPLTVGGGVTIGPITIQGLHIPA Mb3380c|M.bovis_AF2122/97 PAAPLPLTIDIDGQIDGFSTPPITIDRIPLNLGASVTVGPILINGVNIPA MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -------------------------------ALSGPGVGPVVIPVAHVPA MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv APGVGNTTTAPSSGFFNSGAGGVSGFGNVGAGSSGWWNQAPSALLGAGSG Mb3380c|M.bovis_AF2122/97 TPGFGNTTTAPSSGFFNSGDGGVSGFGNFGAGSSGWWNQAQTEVAGAGSG MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M VAGFGNTTSAPSSGFFNSGTGSSSGFGNV-GGGSGWWNFASGGVG--YSG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------QHLLSLLNTPPAEEAAEEP Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------AYLLENLPAPAEDAPAEEP MAB_0669|M.abscessus_ATCC_1997 -------------------------------AALMHLRPAAPGPVPAAAL TH_3113|M.thermoresistible__bu -------------------------------GMLAQLVPLMPALLPVAVA MLBr_01182|M.leprae_Br4923 -------------------------------GMEATVVPQVDQQVNVDVA Rv3350c|M.tuberculosis_H37Rv VGNVGTLGSGVLNLGSGISGFYNTSVLPFGTPAAVSGIGNLGQQLSGVSA Mb3380c|M.bovis_AF2122/97 FANFGSLGSGVLNFGSGVSGLYNTGGLPPGTPAVVSGIGNVGEQLSGLSS MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M VGNVGALGSGVFNLGDGVSGWVNT------IPSMGSGVGNVGDGLAGLFS MUL_0782|M.ulcerans_Agy99 ------------------------------LPADASTVN----------- MSMEG_0868|M.smegmatis_MC2_155 --------------------------------SAAGLAGGNGGNAGLFGN Mflv_0325|M.gilvum_PYR-GCK APAQSAPSRPDQQSFPATMSAPPPPSGAPIAAN-TVSAGSPPAPG---AP Mvan_0415|M.vanbaalenii_PYR-1 AASSPAPTRADQPSPAIAVSAPPPPSSAAATVG-TVATGTAPAPG---AP MAB_0669|M.abscessus_ATCC_1997 SPGDRPIRRPTQHVEPNLAALPLPTSSVVPSGGSSVPVSTPTAPAHTVSS TH_3113|M.thermoresistible__bu ALGGLAGVWAGLSGLAGLAGLTAVPAADGGASAAPVPAGGPSLPSG--SS MLBr_01182|M.leprae_Br4923 TPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAG----- Rv3350c|M.tuberculosis_H37Rv AGTTLRSMLAGNLGLANVGNFNTGFGNVGDVNLGAANIGGHNLGLGNVGD Mb3380c|M.bovis_AF2122/97 AGTALNQSLIINLGLADVGSVNVGFGNVGDFNLGAANIGDLNVGLGNVGG MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M QGADK--ISVFGLGVANHGGLNVGSANVGDANLGSANVGSANVGGGNVGG MUL_0782|M.ulcerans_Agy99 ------------FGLANIGSGNVGNANNGIGNLGSGNLGNFNLGSGNLGS MSMEG_0868|M.smegmatis_MC2_155 GGNGGVGWAGLDGGNGGSGGLLMGIGGAGGAGGVGADGTSAHVDGGTGGT Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRDP-Y-------------EGFSPTVRDSTGAKAPAG Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRDP-G-------------TGFSPTVRDSTSAKAPAS MAB_0669|M.abscessus_ATCC_1997 VPAPSAAISYAIPGLVPPG-------------VSFGPKSTEKSSESAVDT TH_3113|M.thermoresistible__bu APPAPTGSAAPTTGTAPGG-------------AGSPPPAG-HSVPPAPHS MLBr_01182|M.leprae_Br4923 -LSLVNGMGSAMKSLAP------------------TTTKAAESAFKAMGS Rv3350c|M.tuberculosis_H37Rv GNLGLGNIGHGNLGFANLG---LTAGAAGVGNVGFGNAGINNYGLANMGV Mb3380c|M.bovis_AF2122/97 GNVGFGNIGDANFGLGNAG---LAAGLAGVGNIGLGNAGSGNVGFGNMGV MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GNVGVANVGDGNVGGANVGGANVGGANTGDGNWGWGNTGGGNIGWGNTGV MUL_0782|M.ulcerans_Agy99 SNAGWANLGSNNIGGANSGGNNLG----------WGNLGGLNTGFANAGS MSMEG_0868|M.smegmatis_MC2_155 GGTGGGTGGTGGIGGTGGGLFGLLG--------HSGSTGAAGAAGNGGDG Mflv_0325|M.gilvum_PYR-GCK TIPAAASG-----IAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDD Mvan_0415|M.vanbaalenii_PYR-1 GIPAAASG-----VAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDD MAB_0669|M.abscessus_ATCC_1997 VAAVAAAR-----GAVAAQARRRLRGKNKAEAGGR--RHEYLEETAGMG- TH_3113|M.thermoresistible__bu APPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAAARES MLBr_01182|M.leprae_Br4923 AVQSTGRG----LLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTA Rv3350c|M.tuberculosis_H37Rv GNIGFANTGTGNIGIGLVGDHRTGIGGLNSGIGNIGLFNSGTGNVGFFNS Mb3380c|M.bovis_AF2122/97 GNIGFGNTGTNNLGIGLTGDNQTGIGGLNSGAGNIGLFNSGTGNVGLFNS MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GNFGFGNQGSGNIGIGLSGDHQVGFGGWNSGSGNVGLFNSGDGNIGFFNS MUL_0782|M.ulcerans_Agy99 GNFRFANTGNNNIGIGLTGDNQVGIGGLNSGVGNFGLFNSGTGNVGLFNS MSMEG_0868|M.smegmatis_MC2_155 GNGGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGG Mflv_0325|M.gilvum_PYR-GCK GPPEQPAPRVTASTRGAGPMGFAGTVSRGD-EQAGGLTTLAGDSFGGGPR Mvan_0415|M.vanbaalenii_PYR-1 EPPVRQEPRIAATERGAGPMGFAGTVSRDA-AQAGGLTTLPGDPFGGGPK MAB_0669|M.abscessus_ATCC_1997 ATATADVPAYAATGRGTGPLGFAGTAPAAASTHVAATVRLSSD--EARQV TH_3113|M.thermoresistible__bu APIRRRRGQKDGLHGHRHEHQQPASMSAATAPSAAGIRVLGGAGRISRTR MLBr_01182|M.leprae_Br4923 ATRALSPARVAVATESESAPLLGGGLPMAP-MVPGGGSGTGGVNTALRLQ Rv3350c|M.tuberculosis_H37Rv GTGNFGIGNSGRFNTGIGNSGTASTGLFNAGSFSTGIANTGDYNTGSFNA Mb3380c|M.bovis_AF2122/97 GTGNFGLFNSGGYNTGIGNGGTGSTGLFNAGNFNTGVANPGSYNTGSFNV MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GSGNFGIANSGSFNTGIANAGLTNTGWFNSGLANTGWGNAGAYNSGGFNA MUL_0782|M.ulcerans_Agy99 GTGNFGIGNSGAYGTGLFNSGQANT------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGAILIGANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGT Mflv_0325|M.gilvum_PYR-GCK EPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP----------------- Mvan_0415|M.vanbaalenii_PYR-1 APMLPGTWDPDTEPD------ERHNHHDGKDSQ----------------- MAB_0669|M.abscessus_ATCC_1997 IPMLPSTWDADGGDQN---------------------------------- TH_3113|M.thermoresistible__bu GSVPHAEITPGDPTEPSSPTDRAHRPAEPN-------------------- MLBr_01182|M.leprae_Br4923 PRAFVMPRNPAAG------------------------------------- Rv3350c|M.tuberculosis_H37Rv GDTNTGGFNPGGINTGWFNTGHANTGLANAGTFGTGAFMTGDYSNGLLWR Mb3380c|M.bovis_AF2122/97 GDTNTGGFNPGSINTGWFNTGNANTGVANSGTVNTGAFIT---------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GAYNTGSFNPGHVNTGWFNTGDTNTGLGNSGNINTGAFVSGDMNNGFFWR MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSG--------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GGYEGLVGVRVGPTISQFPVTVHAIGGVGPLHVAPVPVPAVHVEITDATV Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GTGQGLIGADYTITIPQIPLTIGGGGILNIPITGAITGLTVQPFTVHG-- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GLGPFTVPPISIPSLPIASITGSVDLAANTISPIRALDPLAGSIGLFLEP Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv FRLSDPFITIDAFQVVAGVLFLENIIVPGLTVSGQILVTPTPIPLTLNLD Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -----------------------------------VGTSTTGIPLDLQVT MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv TTPWTLFPNGFTIPAQTPVTVGMEVANDGFTFFPGGLTFPRASAGVTGLS Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M ILGADTNEIGVDVHIPKPIDKDVTVPIPSIPVLNLGVTIDNEIGAIVAPE MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv VGLDAFTLLPDGFTLDTVPATFDGTILIGDIPIPIIDVPAVPGFGNTTTA Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M IAINPINFNKFMIGNEDSPLTVHIGGGAGPVTIPVFHLSPTPGFGNSGGA MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv PSSGFFNTGGGGGSGFANVGAGTSGWWNQGHDVLAGAGSGVANAGTLSSG Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M PSSGFFNSGDGVS------GFGNFGATVSGWGNVASHASGFENFGTGLSG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv VLNVGSGISGWYNTSTLGAGTPAVVSGIGNLGQQLSGFLANGTVLNRSPI Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M FTNVGDALSGLKNTNSSGLGTSGVGNVGDSLS------------------ MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv VNIGWADVGAFNTGLGNVGDLNWGAANIGAQNLGLGNLGSGNVGFGNIGA Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GNVGFANSGPAVGLAGLGNVGLSNAGSNNWGLANLGVGNIGLANTGTGNI Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GIGLVGDYQTGIGGLNSGSGNIGLFNSGTGNVGFFNTGTGNFGLFNSGSF Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M ------------GLFYAGPDRMSIFNAGLGNLGVGNVGFASVGDGNVGGG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv NTGIGNSGTGSTGLFNAGNFNTGIANPGSYNTGSFNVGDTNTGGFNPGDI Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M NLGDGNVGFGNVGGLNFGSGNWGGFNLGSGNIGSYNFGPGNLGSYNIGFG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv NTGWFNTGIMNTGTRNTGALMSGTDSNGMLWRGDHEGLFG------LSYG Mb3380c|M.bovis_AF2122/97 ----------------------GNDSNGILWRGNFEGLFG------LNVG MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M NAGDYNVGFGNSGLGNIGFGNSGSNNLGIGLTGSGQVGFGGWNSGSGNVG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv ITIPQFPIRITTTGGIGPIVIPDTTILPPLHLQITGDADYSFTVPDIPIP Mb3380c|M.bovis_AF2122/97 ITIPEFPIHWTSTGGIGPIIIPDTTILPPIHLGLTGQANYGFAVPDIPIP MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M LFNSGVGNVGLFNSGTGNWGVGNSGEFDTGLFNAGRYNTGVFNSGVLNTG MUL_0782|M.ulcerans_Agy99 -----------------------------GLLNAGSFNTGLLDVGNANTG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------TATGGRGGDGIDGGTGGAG Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv AIHIGINGVVTVGFTAPEATLLSALKNNGSFISFGPITLSNIDIPPMDFT Mb3380c|M.bovis_AF2122/97 AIHIDFDGAADAGFTASATTLLSALGITGQFR-FGPITVSNVQLNPFNVN MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M VGNAGDYNSGSFNTGASNTGDLNAGDTNTGWANTGNLNTGFGNSG--HLN MUL_0782|M.ulcerans_Agy99 SLNTGSFNMGSFNPGPSNTGALNTGTANTGWFNTGSLNTGPFNIG--DMN MSMEG_0868|M.smegmatis_MC2_155 GMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGG Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv LGLPVLG----------PITGQLG-PIHLEPIVVAGIGVPLE--IEPIPL Mb3380c|M.bovis_AF2122/97 LKLQFLHDAFPNEFPDPTISVQIQVAIPLTSATLGGLALPLQQTIDAIEL MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M TGGFNQGSQNNGFFWRGDAQGQIGFDYTLTVPEIG-LNIDANIPINIPVA MUL_0782|M.ulcerans_Agy99 NGLFNTGEMNNGIFYRGVGQG--NFYFSITTPDL---------------- MSMEG_0868|M.smegmatis_MC2_155 KASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAA Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv DAISLSESIPIRIP-VDIPASVIDGISMSEVVPIDASVDIPAVTITGTTI Mb3380c|M.bovis_AF2122/97 PAISFSQSIPIDIPPIDIPASTINGISMSEVVPIDVSVDIPAVTITGTRI MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M ATLGVIKVGTFTIPTLYLNGNNLTGT-IGPIVVDPITITGPQVDLMVGGP MUL_0782|M.ulcerans_Agy99 -TLPPLEIPGITIPNLSLP---------------PITMRR---------- MSMEG_0868|M.smegmatis_MC2_155 SANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNG---------G Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv SAIPLGFDIRTSAGPLNIPIIDIPAAPGFGNSTQMPSSGFFNTGAGGGSG Mb3380c|M.bovis_AF2122/97 DPIPLNFDVLSSAGPINISIIDIPALPGFGNSTELPSSGFFNTGGGGGSG MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GESLQLALSGPGVGPVVIPVAHVPAVAGFGNTTSAPSSGFFNSGTGSSSG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 NGGNGWVQAYDPNGPAGTTIDKGKAAGGNG------GDGGFNGTGGATGG Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv IGNLGAGVSGLLNQAGAGSLVGTLSGLGNAGTLASGVLNSGTAISGLFNV Mb3380c|M.bovis_AF2122/97 IANFGAGVSGLLNQASS-PMVGTLSGLGNAGSLASGVLNSGVDISGMFNV MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M FGNVGGGSGWWN----FASGGVGYSGVGNVGALGSGVFNLGDGVSGWVNT MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 RGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGG Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv STLDATTPAVISGFSNLGDHMSGVSIDGLIAILTFP-PAESVFDQIIDAA Mb3380c|M.bovis_AF2122/97 STLGS-APAVISGFGNLGNHVSGVSIDGLLAMLTSGGSGGSGQPSIIDAA MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M ------IPSMGSGVGNVGDGLAGLFSQGADKISVFG-------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 AGGVSEGEGGTGGHGGDGGRGGDGALGG---------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv IAELQHLDIGNALALGNVGGVNLGLANVGEFNLGAGNVGNINVGAGNLGG Mb3380c|M.bovis_AF2122/97 IAELRHLNPLNIVNLGNVGSYNLGFANVGDVNLGAGNLGNLNLGGGNLGG MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M ------------LGVANHGGLNVGSANVGDANLGSANVGSANVGGGNVGD MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ---------------------NGGTGGVGLGNGGKGGNGGNGGNGGTYVD Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv SNLGLGNVGTGNLGFGNIGAGNFGFGNAGLTAGAGGLGNVGLGNAGSGSW Mb3380c|M.bovis_AF2122/97 QNLGLGNLGDGNVGFGNLGHGNVGFGNSGLGALPG-IGNIGLGNAGSNNV MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GNVGVANVGDGNVGGANVGGANVGGANTGD-------GNWGWGNTGGGNI MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKG Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GLANVGVGNIGLANTGTGNIGIGLTGDYRTGIGGLNSGTGNLGLFNSGTG Mb3380c|M.bovis_AF2122/97 GFGNMGLGNIGFGNTGTNNLGIGLTGDNQTGFGGLNSGAGNLGLFNSGTG MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GWGNTGVGNFGFGNQGSGNIGIGLSGDHQVGFGGWNSGSGNVGLFNSGDG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVV Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv NIGFFNTGTGNFGLFNSGSYSTGVGNAGTASTGLFNAGNFNTGLANAGSY Mb3380c|M.bovis_AF2122/97 NIGFFNTGTGNWGLFNSGSYNTGIGNSGTGSTGLFNAGSFNTGLANAGSY MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M NIGFFNSGSGNFGIANSGSFNTGIANAGLTNTGWFNSGLANTGWGNAGAY MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 QANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIG-AGGN Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv NTGSLNVGSFNTGGVNPGTVNTGWFNTGHTNTGLFNTGNVNTGAFNSGSF Mb3380c|M.bovis_AF2122/97 NTGSLNAGNTNTGGFNPGNVNTGWFNAGHTNTGGFNTGNVNTAAFNSGSF MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M NSGGFNAGAYNTGSFNPGHVNTGWFNTGDTNTGLGNSGNINTGAFVSGDM MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGG Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv NNGALWTGDYHGLVGFSFSIDIAGSTLLDLNETLNLGPIHIEQIDIPGMS Mb3380c|M.bovis_AF2122/97 NNGALWTGDHHGLVGFSYSIEITGSTLVDINETLNLGPVHIDQIDIPGMS MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M NNGFFWRGTGQGLIGADYTITIP------------HIPITVGGGGILKLP MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 NGGPSWVQSGYG--------------------------------STLGGN Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv LFDVHEIVEIGPFTIPQVDVPAIPLEIHESIHMDPIVLVPATTIPAQTRT Mb3380c|M.bovis_AF2122/97 LFDIHELVNIGPFRIEPIDVPAVVLDIHETMVIPPIVFLPSMTIGGQTYT MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M LTGEISNLKVEPFGLRGEGGGGIPLIAHFTLLG----------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ATGTATAGKGGEASNGGVAGNGG--------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv IPLDIPASPGS-TMTLPLISMRFEGEDWILGSTAAIPNFGDPFPAPTQGI Mb3380c|M.bovis_AF2122/97 IPLDTPPAPAPPPFRLPLLFVNALGDNWIVGASNSTGMSGGFVTAPTQGI MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv TIHTGPGPGTTGELKISIPGFEIPQIATTRFLLDVNISGGLPAFTLFAGG Mb3380c|M.bovis_AF2122/97 LIHTGPSSATTGSLALTLPTVTIPTITTSPIPLKIDVSGGLPAFTLFPGG MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -----DTKATTIDIPGTSLSFELPSLP---VAIKVDIN------------ MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv LTIPTNAIPLTIDASGALDPITIFPGGYTIDPLPLHLALNLTVPDSSIPI Mb3380c|M.bovis_AF2122/97 LNIPQNAIPLTIDASGVLDPITIFPGGFTIDPLPLSLALNISVPDSSVPI MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -----DELSVISTPEITINPITFNEFVIGSDETPFDVSIDGGIEPLTVTV MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------------NALVMAAGTTGVATGNTATGGDGGAATTAGAT Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv IDVPPTPGFGNTTATPSSGFFNSGAGGVSGFGNVGSNLSGWWNQAASALA Mb3380c|M.bovis_AF2122/97 IIVPPTPGFGNATATPSSGFFNSGAGGVSGFGNFGAGSSGWWNQAHAALA MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M FHLSPTPGFGNSGGAPSSGFFNSGDG-VSGFGNFGATVSGWG-----NVA MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGP Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GSGSGVLNVGTLGSGVLNVGSGVSGIYNTSVLPLGTPAVLSGLGNVGHQL Mb3380c|M.bovis_AF2122/97 GAGSGVLNVGTLNSGVLNVGSGISGLYNTAIVGLGTPALVSGAGNVGQQL MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M SHASGFENFGSGLSGFTNVGDVLSGLKNTNSSGLGT----SGVGNVGDSL MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 VGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGE Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv SGVSAAGTALNQIPILNIGLADVGNFNVGFGNVGDVNLGAANLGAQNLGL Mb3380c|M.bovis_AF2122/97 SGVLAAGTALTQSPIINLGLADVGNYNLGLGNVGDFNLGAANLGDLNLGL MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M SGLFYA--GPDRMSIFNAGLGNLGVGNVGFASVGDGNVGGGNLGDGNVGF MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 HNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGG Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GNVGTGNLGFANVGHGNIGFGNSG---LTAGAAGLGNTGFGNAGSANYGF Mb3380c|M.bovis_AF2122/97 GNIGNANVGFGNIGHGNVGFGNSG---LGR-----------RSASAISGW MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GNVGGLNFGSGNWGGFNLGSGNIGSYNFGPGNLGSYNIGFGNAGDYNVGF MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 NGGADGTPGTAGTTGANNP------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv ANQGVRNIGLANTGTGNIGIGLVGDNLTGIGGLNSGAGNIGLFNSGTGNI Mb3380c|M.bovis_AF2122/97 AMRAAPTLAWP--------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GNSGLGNIGFGNSGSNNLGIGLTGSGQVGFGGWNSGSGNVGLFNSGDGNV MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GFFNSGTGNFGIGNSGSFNTGIGNSGTGSTGLFNAGSFNTGVANAGSYNT Mb3380c|M.bovis_AF2122/97 --------TWVWATSGSPTPAPTTSGLGWP-------ATTRPASAA---- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GLFNSGTGNWGVGNSGEFDTGLFNAGRYNTGVFNSGVLNTGVGNAGDYNS MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GSFNAGDTNTGGFNPGTINTGWFNTGHTNTGIANSGNVGTGAFMSGNFSN Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GSFNTGASNTGDLNAGDTNTGWANTGNLNTGFGNSGHLNTGGFNQGSQNN MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GLLWRGDHEGLFSLFYSLDVPRITIVDAHLDGGFGPVVLPPIPVPAVNAH Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GFFWRGDAQGQIGFDYTITIPEIAVG-----------FNVQVPLDIPLSG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv LTGNVAMGAFTIPQIDIPALTPNITGSAAFRIVVGSVRIPPVSVIVEQII Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M HLGEIRLSEFMLPPIHLNPVDGNSLTGTIGPIVVDPITITGP-------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv NASVGAEMRIDPFEMWTQGTNGLGITFYSFGSADGSPYATGPLVFGAGTS Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv DGSHLTISASSGAFTTPQLETGPITLGFQVPGSVNAITLFPGGLTFPATS Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv LLNLDVTAGAGGVDIPAITWPEIAASADGSVYVLASSIPLINIPPTPGIG Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M -----------QVDLMVGGPGESLQLALSGPGVGPVVIPVAHVPAVAGFG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv NSTITPSSGFFNAGAGGGSGFGNFGAGTSGWWNQAHTALAGAGSGFANVG Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M NTTSAPSSGFFNSGTGSSSGFGNVGGGSGWWN---FASGGVGYSGVGNVG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv TLHSGVLNLGSGVSGIYNTSTLGVGTPALVSGLGNVGHQLSGLLSGGSAV Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M ALGSGVFNLGDGVSGWVNT------IPSMGSGVGNVGDGLAGLFSQGADK MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv NPVTVLNIGLANVGSHNAGFGNVGEVNLGAANLGAHNLGFGNIGAGNLGF Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M --ISVFGLGVANHGGLNVGSANVGDANLGSANVGSANVGGGNVGDGNVGV MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GNIGHGNVG---VGNSGLTAGVPGLGNVGLGNAGGNNWGLANVGVGNIGL Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M ANVGDGNVGGANVGGANVGGANTGDGNWGWGNTGGGNIGWGNTGVGNFGF MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv ANTGTGNIGIGLTGDYQTGIGGLNSGAGNLGLFNSGAGNVGFFNTGTGNF Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GNQGSGNIGIGLSGDHQVGFGGWNSGSGNVGLFNSGDGNIGFFNSGSGNF MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GLFNSGSFNTGVGNSGTGSTGLFNAGSFNTGVANAGSYNTGSFNVGDTNT Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GIANSGSFNTGIANAGLTNTGWFNSGLANTGWGNAGAYNSGGFNAGAYNT MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv GGFNPGSINTGWLNAGNANTGVANAGNVNTGAFVTGNFSNGILWRGDYQG Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M GSFNPGHVNTGWFNTGDINTGLGNSGNINTGAFVSGDMNNGFFWRGTGQG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv LAGFAVGYTLPLFPAVGADVSGGIGPITVLPPIHIPPIPVGFAAVGGIGP Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M LIGADYTITIPQIPLT----------------------------IGGGGI MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv IAIPDISVPSIHLGLDPAVHVGSITVNPITVRTPPVLVSYSQGAVTSTSG Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M LNIPITGAITGLTVQSFTVHGVGSAATPIPVNLHLNVDGESGGATVSVHI MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv PTSEIWVKPSFFPGIRIAPSSGGGATSTQGAYFVGPISIPSGTVTFPGFT Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M PN----------------------------------------------TD MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv IPLDPIDIGLPVSLTIPGFTIPGGTLIPTLPLGLALSNGIPPVDIPAIVL Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M VSFDVHVDGLPITLDLPLDSEVRPIVVPDIPISRIP-------IVLSLGS MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv DRILLDLHADTTIGPINVPIAGFGGAPGFGNSTTLPSSGFFNTGAGGGSG Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M DSTSLNTAIGAGIGPISIPILDLPTAPGFGNATDSPSSGFFNSGPGGVSG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Rv3350c|M.tuberculosis_H37Rv FSNTGAGMSGLLNAMSDPLLGSASGFANFG-TQLSGILNRGAGISGVYNT Mb3380c|M.bovis_AF2122/97 -------------------------------------------------- MAV_4704|M.avium_104 -------------------------------------------------- MMAR_4621|M.marinum_M FGNVGDTLSGVWNFG-----SYASGLQNYGGSLLSGITNLGGATSGVGNT MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK ------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 ------------------------------- MAB_0669|M.abscessus_ATCC_1997 ------------------------------- TH_3113|M.thermoresistible__bu ------------------------------- MLBr_01182|M.leprae_Br4923 ------------------------------- Rv3350c|M.tuberculosis_H37Rv GALGVVTAAVVSGFGNVGQQLSGLLFTGVGP Mb3380c|M.bovis_AF2122/97 ------------------------------- MAV_4704|M.avium_104 ------------------------------- MMAR_4621|M.marinum_M SDLGLAIAGVISGIGNVGSQLSGLFLEGSVP MUL_0782|M.ulcerans_Agy99 ------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------