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M. tuberculosis H37Rv Rv3347c (PPE55)

annotation: PPE FAMILY PROTEIN
coordinates: 3743711 - 3753184
length: 3157

NFPVLPPEINSVLMYSGAGSSPLLAAAAAWDGLAEELGSAAVSFGQVTSGLTAGVWQGAAAAAMAAAAAP
YAGWLGSVAAQAVAVAGQARAAVAAFEAALAATVDPAAVAVNRMAMRALAMSNLLGQNAAAIAAVEAEYE
LMWAADVAAMAGYHSGASAAAAALPAFSPPAQALGGGVGAFLNALFAGPAKMLRLNAGLGNVGNYNVGLG
NVGIFNLGAANVGAQNLGAANAGSGNFGFGNIGNANFGFGNSGLGLPPGMGNIGLGNAGSSNYGLANLGV
GNIGFANTGSNNIGIGLTGDNLTGIGGLNSGTGNLGLFNSGTGNIGFFNSGTGNFGVFNSGSYNTGVGNA
GTASTGLFNVGGFNTGVANVGSYNTGSFNAGNTNTGGFNPGNVNTGWLNTGNTNTGIANSGNVNTGAFIS
GNFSNGVLWRGDYEGLWGLSGGSTIPAIPIGLELNGGVGPITVLPIQILPTIPLNIHQTFSLGPLVVPDI
VIPAFGGGTAIPISVGPITISPITLFPAQNFNTTFPVGPFFGLGVVNISGIEIKDLAGNVTLQLGNLNID
TRINQSFPVTVNWSTPAVTIFPNGISIPNNPLALLASASIGTLGFTIPGFTIPAAPLPLTIDIDGQIDGF
STPPITIDRIPLNLGASVTVGPILINGVNIPATPGFGNTTTAPSSGFFNSGDGGVSGFGNFGAGSSGWWN
QAQTEVAGAGSGFANFGSLGSGVLNFGSGVSGLYNTGGLPPGTPAVVSGIGNVGEQLSGLSSAGTALNQS
LIINLGLADVGSVNVGFGNVGDFNLGAANIGDLNVGLGNVGGGNVGFGNIGDANFGLGNAGLAAGLAGVG
NIGLGNAGSGNVGFGNMGVGNIGFGNTGTNNLGIGLTGDNQTGIGGLNSGAGNIGLFNSGTGNVGLFNSG
TGNFGLFNSGSFNTGIGNGGTGSTGLFNAGNFNTGVANPGSYNTGSFNVGDTNTGGFNPGSINTGWFNTG
NANTGVANSGNVDTGALMSGNFSNGILWRGNFEGLFGLNVGITIPEFPIHWTSTGGIGPIIIPDTTILPP
IHLGLTGQANYGFAVPDIPIPAIHIDFDGAADAGFTAPATTLLSALGITGQFRFGPITVSNVQLNPFNVN
LKLQFLHDAFPNEFPDPTISVQIQVAIPLTSATLGGLALPLQQTIDAIELPAISFSQSIPIDIPPIDIPA
STINGISMSEVVPIDVSVDIPAVTITGTRIDPIPLNFDVLSSAGPINISIIDIPALPGFGNSTELPSSGF
FNTGGGGGSGIANFGAGVSGLLNQASSPMVGTLSGLGNAGSLASGVLNSGVDISGMFNVSTLGSAPAVIS
GFGNLGNHVSGVSIDGLLAMLTSGGSGGSGQPSIIDAAIAELRHLNPLNIVNLGNVGSYNLGFANVGDVN
LGAGNLGNLNLGGGNLGGQNLGLGNLGDGNVGFGNLGHGNVGFGNSGLGALPGIGNIGLGNAGSNNVGFG
NMGLGNIGFGNTGTNNLGIGLTGDNQTGFGGLNSGAGNLGLFNSGTGNIGFFNTGTGNWGLFNSGSYNTG
IGNSGTGSTGLFNAGSFNTGLANAGSYNTGSLNAGNTNTGGFNPGNVNTGWFNAGHTNTGGFNTGNVNTG
AFNSGSFNNGALWTGDHHGLVGFSYSIEITGSTLVDINETLNLGPVHIDQIDIPGMSLFDIHELVNIGPF
RIEPIDVPAVVLDIHETMVIPPIVFLPSMTIGGQTYTIPLDTPPAPAPPPFRLPLLFVNALGDNWIVGAS
NSTGMSGGFVTAPTQGILIHTGPSSATTGSLALTLPTVTIPTITTSPIPLKIDVSGGLPAFTLFPGGLNI
PQNAIPLTIDASGVLDPITIFPGGFTIDPLPLSLALNISVPDSSVPIIIVPPTPGFGNATATPSSGFFNS
GAGGVSGFGNFGAGSSGWWNQAHAALAGAGSGVLNVGTLNSGVLNVGSGISGLYNTAIVGLGTPALVSGA
GNVGQQLSGVLAAGTALTQSPIINLGLADVGNYNLGLGNVGDFNLGAANLGDLNLGLGNIGNANVGFGNI
GHGNVGFGNSGLGAALGIGNIGLGNAGSTNVGLANMGVGNIGFANTGTNNLGIGLTGDNQTGIGGLNSGA
GNIGLFNSGTGNIGFFNSGTGNWGLFNSGSFNTGIGNSGTGSTGLFNAGGFTTGLANAGSYNTGSFNVGD
TNTGGFNPGSINTGWFNTGNANTGIANSGNVDTGALMSGNFSNGILWRGNYEGLFSYSYSLDVPRITILD
AHFTGAFGPVVVPPIPVLAINAHLTGNAAMGAFTIPQIDIPALNPNVTGSVGFGPIAVPSVTIPALTAAR
AVLDMAASVGATSEIEPFIVWTSSGAIGPTWYSVGRIYNAGDLFVGGNIISGIPTLSTTGPVHAVFNAAS
QAFNTPALNIHQIPLGFQVPGSIDAITLFPGGLTFPANSLLNLDVFVGTPGATIPAITFPEIPANADGEL
YVIAGDIPLINIPPTPGIGNTTTVPSSGFFNTGAGGGSGFGNFGANMSGWWNQAHTALAGAGSGIANVGT
LHSGVLNLGSGLSGIYNTSTLPLGTPALVSGLGNVGDHLSGLLASNVGQNPITIVNIGLANVGNGNVGLG
NIGNLNLGAANIGDVNLGFGNIGDVNLGFGNIGGGNVGFGNIGDANFGFGNSGLAAGLAGMGNIGLGNAG
SGNVGWANMGLGNIGFGNTGTNNLGIGLTGDNQSGIGGLNSGTGNIGLFNSGTGNIGFFNSGTANFGLFN
SGSYNTGIGNSGVASTGLVNAGGFNTGVANAGSYNTGSFNAGDTNTGGFNPGSTNTGWFNTGNANTGVAN
AGNVNTGALITGNFSNGILWRGNYEGLAGFSFGYPIPLFPAVGADVTGDIGPATIIPPIHIPSIPLGFAA
IGHIGPISIPNIAIPSIHLGIDPTFDVGPITVDPITLTIPGLSLDAAVSEIRMTSGSSSGFKVRPSFSFF
AVGPDGMPGGEVSILQPFTVAPINLNPTTLHFPGFTIPTGPIHIGLPLSLTIPGFTIPGGTLIPQLPLGL
GLSGGTPPFDLPTVVIDRIPVELHASTTIGPVSLPIFGFGGAPGFGNDTTAPSSGFFNTGGGGGSGFSNS
GSGMSGVLNAISDPLLGSASGFANFGTQLSGILNRGAGISGVYNTGTLGLVTSAFVSGFMNVGQQLSGLL
FAGTGP*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv3347cPPE55-100% (3157)PPE FAMILY PROTEIN
M. tuberculosis H37RvRv3350cPPE560.067.17% (3019) PPE family protein
M. tuberculosis H37RvRv3343cPPE540.046.38% (2721) PPE family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3380cPPE55a0.099.46% (2044) hypothetical protein Mb3380c
M. gilvum PYR-GCKMflv_0325-3e-2738.29% (175) PPE protein
M. leprae Br4923MLBr_01182-4e-3145.29% (170) PPE-family protein
M. abscessus ATCC 19977MAB_0669-1e-2636.05% (172) PPE-family protein
M. marinum MMMAR_0642-0.035.78% (3027) PPE family protein
M. avium 104MAV_4704-3e-5261.14% (175) PPE family protein
M. smegmatis MC2 155MSMEG_0619-2e-2739.43% (175) PPE family protein
M. thermoresistible (build 8)TH_3113-2e-3040.93% (193) PUTATIVE PPE protein
M. ulcerans Agy99MUL_0965-1e-13436.63% (991) PPE family protein
M. vanbaalenii PYR-1Mvan_0415-1e-2838.29% (175) PPE protein

CLUSTAL 2.0.9 multiple sequence alignment


Rv3347c|M.tuberculosis_H37Rv        ----------MN---FPVLPPEINSVLMYSGAGSSPLLAAAAAWDGLAEE
Mb3380c|M.bovis_AF2122/97           ----------MN---FPVLPPEINSVLMYSGAGSSPLLAAAAAWDGLAEE
MMAR_0642|M.marinum_M               ----------MN---FAVLPPEINSARLTIGAGLGPMLEAANAWQGLAGE
MUL_0965|M.ulcerans_Agy99           ----------MN---FIMLPPEINSARIFAGAGVGPTLAAAAAWDALAAD
MAV_4704|M.avium_104                ----------MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEE
MLBr_01182|M.leprae_Br4923          ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK          MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1       ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155      ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0669|M.abscessus_ATCC_1997      ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
TH_3113|M.thermoresistible__bu      ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
                                                       .** :*  :  *.* ..   *.  *  :. :

Rv3347c|M.tuberculosis_H37Rv        LGSAAVSFGQVTSGLTAGVWQGAAAAAMAAAAAPYAGWLGSVAAQAVAVA
Mb3380c|M.bovis_AF2122/97           LGSAAVSFGQVTSGLTAGVWQGAAAAAMAAAAAPYAGWLGSVAAQAVAVA
MMAR_0642|M.marinum_M               LGSAASAFSSVTTDLVSGGWQGAASTAMASAAAPYLKWLTTAAAQAGQAA
MUL_0965|M.ulcerans_Agy99           LASAAQSFAAITVGLVGEAWQGAAATAMAAAARPYASWLGTAAARAAVTA
MAV_4704|M.avium_104                LASSAQSFSSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVS
MLBr_01182|M.leprae_Br4923          LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK          YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1       YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155      YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0669|M.abscessus_ATCC_1997      YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
TH_3113|M.thermoresistible__bu      YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
                                       :*  :           ::* .:         *  **   :* .   .

Rv3347c|M.tuberculosis_H37Rv        GQARAAVAAFEAALAATVDPAAVAVNRMAMRALAMSNLLGQNAAAIAAVE
Mb3380c|M.bovis_AF2122/97           GQARAAVAAFEAALAATVDPAAVAVNRMAMRALAMSNLLGQNAAAIAAVE
MMAR_0642|M.marinum_M               TQVRLAAAAFEAALAATVHPAAISANRSQFVSLVVSNLLGQNAPAIAAAE
MUL_0965|M.ulcerans_Agy99           AQANAAAAVFEAAQAATAHPELVAANRNQLVSLVVSNLFGQNAPAIASTE
MAV_4704|M.avium_104                HQASAIATAFEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIE
MLBr_01182|M.leprae_Br4923          TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK          VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1       AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155      VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997      AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu      AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
                                     *    . ..  * :       :  *:     *  :* :* *: .**  *

Rv3347c|M.tuberculosis_H37Rv        AEYELMWAADVAAMAGYHSGASAAAAALPAFSPPAQALGGGVGAFLNALF
Mb3380c|M.bovis_AF2122/97           AEYELMWAADVAAMAGYHSGASAAAAALPAFSPPAQALGGGVGAFLNAIF
MMAR_0642|M.marinum_M               AAYEQMWAQDVAAMFGYRSGAESIAAALTPFPL-----------------
MUL_0965|M.ulcerans_Agy99           AAYDQLWAQDVAAMAGYHSGASAVAAQLAPW-------------------
MAV_4704|M.avium_104                AAYEQMWASDVAAMFGYHADASAAVAKLPPW-------------------
MLBr_01182|M.leprae_Br4923          AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAP----------------
Mflv_0325|M.gilvum_PYR-GCK          ADYVRMWIQAATTMATYQSVSGAALAATPTSAP-----------------
Mvan_0415|M.vanbaalenii_PYR-1       ADYVRMWIQAATTMATYQAVSGAALAATPTATP-----------------
MSMEG_0619|M.smegmatis_MC2_155      ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAP-----------------
MAB_0669|M.abscessus_ATCC_1997      ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQ-----------------
TH_3113|M.thermoresistible__bu      ADYARMWIQAATTMATYEAVASAAVSATPRTVA-----------------
                                    * *  :*   .::*  *.:      .                        

Rv3347c|M.tuberculosis_H37Rv        AGPAKMLRLNAGLGNVGNYNVGLGNVGIFNLGAANVGAQNLGAANAGSGN
Mb3380c|M.bovis_AF2122/97           AGPAKMLRLNAGLGNVGNYNVGLGNVGIFNLGAANVGAQNLGAANAGSGN
MMAR_0642|M.marinum_M               ----------QAAGSVVTANLGFANVGFRNFGNGNVGDYNLGSGNLGSEN
MUL_0965|M.ulcerans_Agy99           ------------------------QQALRTLQN-----------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        FGFGNIGNANFGFGNSGLGLPPGMGNIGLGNAGSSNYGLANLGVGNIGFA
Mb3380c|M.bovis_AF2122/97           FGFGNIGNANFGFGNSGLGLPPGMGNIGLGNAGSSNYGLANLGVGNIGFA
MMAR_0642|M.marinum_M               VGSSNIGSGNIGFGNSGPALTAALNNIGFGNTGSNNIGFGNTGNNNIGFG
MUL_0965|M.ulcerans_Agy99           ----RVAGATTALPPPGPAAAAALP-------GAAAVGFP----------
MAV_4704|M.avium_104                ----NEVLQNLGFSNASTAVTRPAG------SGAVARGYT----------
MLBr_01182|M.leprae_Br4923          --PLGVNEVGLAQEVVEEVVEEVVEEVVEAEQAISQAALD----------
Mflv_0325|M.gilvum_PYR-GCK          ----APSVLLPGVGEAGRAAADMSAFAAQPMAAQAGAAFD----------
Mvan_0415|M.vanbaalenii_PYR-1       ----APFVLAPGVGEAGRAAADVTAFAAQAQAAEAGSALD----------
MSMEG_0619|M.smegmatis_MC2_155      ----APFLLKPGVGEAGSASASVQQMSAQATAAESGSSLD----------
MAB_0669|M.abscessus_ATCC_1997      ----PPAILSPG-GEARSDQSDVPGSPDQIMKMLQG--------------
TH_3113|M.thermoresistible__bu      ----PPPILGAGTGESATAAITGAHVTAELRAAESRTLLD----------
                                               .                                      

Rv3347c|M.tuberculosis_H37Rv        NTGSNNIGIGLTGDNLTGIGGLNSGTGNLGLFNSGTGNIGFFNSGTGNFG
Mb3380c|M.bovis_AF2122/97           NTGSNNIGIGLTGDNLTGIGGLNSGTGNLGLFNSGTGNIGFFNSGTGNFG
MMAR_0642|M.marinum_M               NTGDNNRGIGLTGTGQFGLGGLNSGSGNIGLFNSGTGNFGIGNSGTGNWG
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        VFNSG-SYNTGVGNAGTASTGLFNVGGFNTGVANVGSYNTGSFNAGNTNT
Mb3380c|M.bovis_AF2122/97           VFNSG-SYNTGVGNAGTASTGLFNVGGFNTGVANVGSYNTGSFNAGNTNT
MMAR_0642|M.marinum_M               IGNSGNSYNTGIGNSGDANTGFFNAGVANTGIGNVGSYNTGGFNPGDANT
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        GGFNPGNVNTGWLNTGNTNTGIANSGNVNTGAFISGNFSNGVLWRGDYEG
Mb3380c|M.bovis_AF2122/97           GGFNPGNVNTGWLNTGNTNTGIANSGNVNTGAFISGNFSNGVLWRGDYEG
MMAR_0642|M.marinum_M               GGFNTGSYNTGYLNRGDYNTGVANFGNVNTGALNTGDYNNGFLWRGDNQG
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        -LWGLSGGSTIPAIPIGLELNGGVGPITVLPIQILPTIPLNIHQTFSLGP
Mb3380c|M.bovis_AF2122/97           -LWGLSGGSTIPAIPIGLELNGGVGPITVLPIQILPTIPLNIHQTFSLGP
MMAR_0642|M.marinum_M               LIFGEPGFGNSTTVPSSGFFNSGEGSASGFFNSGANNSGFFNDSSGPIGN
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        LVVPDIVIPAFGGGTAIPISVGPITISPITLFPAQNFNTTFPVG------
Mb3380c|M.bovis_AF2122/97           LVVPDIVIPAFGGGTAIPISVGPITISPITLFPAQNFNTTFPVG------
MMAR_0642|M.marinum_M               SGFANTGVLQSGLVNSGNTISGLLNSSLVPITTPAYISGVLNTGSNLAGF
MUL_0965|M.ulcerans_Agy99           ---------------------------------------VLHIG------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        ----PFFGLGVVNISGIEIKDLAGNVTLQLG--------------NLNID
Mb3380c|M.bovis_AF2122/97           ----PFFGLGVVNISGIEIKDLAGNVTLQLG--------------NLNID
MMAR_0642|M.marinum_M               LLGPTLFNIGFANDGVGNILAHANVGNYNIGGNGNVGDYNIFGSGNAGSY
MUL_0965|M.ulcerans_Agy99           -------NIGFANLSVG------NIGDYNLG-------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        TRINQSFPVTVNWSTP-------------AVTIFPNGISIPNNPLALLAS
Mb3380c|M.bovis_AF2122/97           TRINQSFPVTVNWSTP-------------AVTIFPNGISIPNNPLALLAS
MMAR_0642|M.marinum_M               NIFGSGNIGSLNLGSGNFGGTNFGSGNIGSLNLGSANIGSYNIGSASLGS
MUL_0965|M.ulcerans_Agy99           ----SGNTGSFNLGSG-------------------------NIGDASLGS
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        --ASIGTLGFTIPGFTIPAAPLPLTIDIDGQIDGFSTPPITIDRIPLNLG
Mb3380c|M.bovis_AF2122/97           --ASIGTLGFTIPGFTIPAAPLPLTIDIDGQIDGFSTPPITIDRIPLNLG
MMAR_0642|M.marinum_M               YNVGFGNLGDYNTGFGNAGSYNQGLANTGSNNAGFANTGNGNIGIGLTGD
MUL_0965|M.ulcerans_Agy99           -----GNAGDSNVGFG----------NFGSNNVGIGNNGNNNIGIGLNGD
MAV_4704|M.avium_104                -----------------------------SRIAGFLAPRAPQ--------
MLBr_01182|M.leprae_Br4923          ----------------------------QAVNEGMEATVVPQVDQQVNVD
Mflv_0325|M.gilvum_PYR-GCK          ---------VSNIIADIIRLYGEVLRFLFEPIFNFLRDPIGNTFALITDF
Mvan_0415|M.vanbaalenii_PYR-1       ---------LSNIIADLIRAYGELLRFLFEPIFDFLRDPLGNTIKLITDF
MSMEG_0619|M.smegmatis_MC2_155      ---------LSSIISDLLNQYLQGVPGG-QAILDFLKDPLGNLGRLLTDF
MAB_0669|M.abscessus_ATCC_1997      --------------------------------FQQWFEKMG--------F
TH_3113|M.thermoresistible__bu      ---------EINELIDRLFAPLFPPGFADALPDGLLGTLLAPLLPGATGD
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        ASVTVGPILINGVNIPATPGFGNTTTAPSSGFFNSGDGGVSGFGNFGAGS
Mb3380c|M.bovis_AF2122/97           ASVTVGPILINGVNIPATPGFGNTTTAPSSGFFNSGDGGVSGFGNFGAGS
MMAR_0642|M.marinum_M               GQIGIGALNSG----IGNAGLFNSGTD-NVGLFNSGSGNIG-IGNSGSGN
MUL_0965|M.ulcerans_Agy99           DLIGIGALNSG----AGNLGFGNSGTN-NIGFFNSGDNNIG-FFNSGSG-
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          VATPQTAVPDS---------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          LTNPVQALITWGP-------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       LTNPAQALITWGP-------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      MTNPAGALATWWP-------------------------------------
MAB_0669|M.abscessus_ATCC_1997      NPATSAVLAVIML-------------------------------------
TH_3113|M.thermoresistible__bu      GPPMATIMSFLLMG------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        SG-------------------------WWNQAQTEVAGAGSGFANFGSLG
Mb3380c|M.bovis_AF2122/97           SG-------------------------WWNQAQTEVAGAGSGFANFGSLG
MMAR_0642|M.marinum_M               TGLLNAGVANWGLENPGTANTGIGNAGQYNTGLHNVGAANTGFYNNGSYN
MUL_0965|M.ulcerans_Agy99           -----------------------------NFGFENAGDINTGFWNGRDTN
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        SGVLNFGSGVSGLYNTGGLPPG----------------------------
Mb3380c|M.bovis_AF2122/97           SGVLNFGSGVSGLYNTGGLPPG----------------------------
MMAR_0642|M.marinum_M               TGGFNVGSTNTGSFDAGSANTGNFNPGDTNTGSYNPGNVNTGFFDTGNYN
MUL_0965|M.ulcerans_Agy99           TG------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               NGFFVTSDNQGQIAINLSVTTPHIPIDVQSIVPVNQVYTLGGNTIQVSEA
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               GSVFPRTYYLGGLFFLGPINLGASTLTIPTVTIALGGPSTNIPISIVGAV
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               ESRTITFLDIPAAPGFGNTTAGPSSGFFNAGTGGNSGFANFGAASSGLWN
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        ---TPAVVSGIGNVGEQLSGLSSAGTALN---------------------
Mb3380c|M.bovis_AF2122/97           ---TPAVVSGIGNVGEQLSGLSSAGTALN---------------------
MMAR_0642|M.marinum_M               SGVAAAGNSGVQNFGSLASGWANLGNTLSGFYNTSTANLAAPANLSGLFN
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        ------------QSLIINLGLADVGSVNVGFGNVGDFNLGAANIGDLNVG
Mb3380c|M.bovis_AF2122/97           ------------QSLIINLGLADVGSVNVGFGNVGDFNLGAANIGDLNVG
MMAR_0642|M.marinum_M               VGTDLAGVLRDANGTILNLGLADLGHLNVGSGNVGDFNVGSANIGSANFG
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        LGNVGGGNVGFGNIGDANFGLGNAGLAAGLAGVGNIGLGNAGSGNVGFGN
Mb3380c|M.bovis_AF2122/97           LGNVGGGNVGFGNIGDANFGLGNAGLAAGLAGVGNIGLGNAGSGNVGFGN
MMAR_0642|M.marinum_M               FGNVGSDNLGSGNIGSGNIGFGNAGARLTDA-FNNIGFGNTGDNNIGFGN
MUL_0965|M.ulcerans_Agy99           -----------------------------------------------FGN
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        MGVGNIGFGNTGTNNLGIGLTGDNQTG---IGGLNSGAGNIGLFNSGTGN
Mb3380c|M.bovis_AF2122/97           MGVGNIGFGNTGTNNLGIGLTGDNQTG---IGGLNSGAGNIGLFNSGTGN
MMAR_0642|M.marinum_M               TGNGNFGFGNTGNGNIGIGLTGAGQRGVNFAGGLNSGSGNIGLFNSGTNN
MUL_0965|M.ulcerans_Agy99           SGLSNFGFG-----------------------------------NSGVNN
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        VGLFNSGTGNFGLFNSGSFNTGIGNGGTGSTGLFNAGNFNTGVANPGSYN
Mb3380c|M.bovis_AF2122/97           VGLFNSGTGNFGLFNSGGYNTGIGNGGTGSTGLFNAGNFNTGVANPGSYN
MMAR_0642|M.marinum_M               VGIGNSGTGNWGIGNSGSLNTGFGNAGSTNTGLFNTGMVNTGIANVGDYN
MUL_0965|M.ulcerans_Agy99           VGAGNGGSSNVGLGNAGLLNT-------------------------GSFN
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        TGSFNVGDTNTGGFNPGSINTGWFNTGNANTGVANSGNVDTGALMSGNFS
Mb3380c|M.bovis_AF2122/97           TGSFNVGDTNTGGFNPGSINTGWFNTGNANTGVANSGTVNTGAFITGNDS
MMAR_0642|M.marinum_M               TGWFNTGDVNTGAANRGDYNTGWYNTGNYSTGFANAGNIDTGLLISGDMG
MUL_0965|M.ulcerans_Agy99           SGKFNTGDFNSGSMN-----TGYFNSSGHNTGLGNSG-------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        NGILWRGNFEGLFGLNVGITIPEFPIHWTSTGGIGPIIIPDTTILP----
Mb3380c|M.bovis_AF2122/97           NGILWRGNFEGLFGLNVGITIPEFPIHWTSTGGIGPIIIPDTTILP----
MMAR_0642|M.marinum_M               NGFAWRGDQQGQVSASYVIHVPEIPAHVDASAPINIPLTANFTNTLYSGI
MUL_0965|M.ulcerans_Agy99           -----------------------------------------FTN------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               TMEDINFGFTVAIGPLPVLTGTIDSVTLAPITATGPAISFNIGDPKGTTV
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        ---------------------------------PIHLG------------
Mb3380c|M.bovis_AF2122/97           ---------------------------------PIHLG------------
MMAR_0642|M.marinum_M               VSIPATASLGPVDWTIFDIPAVTGLFNSTSSPSSGFFNGGTGTVSGIANF
MUL_0965|M.ulcerans_Agy99           ---------------------------------TGFFN------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        ----------------------------------LTGQANYGFAVPDIPI
Mb3380c|M.bovis_AF2122/97           ----------------------------------LTGQANYGFAVPDIPI
MMAR_0642|M.marinum_M               GGDISGFQNFGTSALSGFKNVGSLQSGLLNIGDTVSGLFNTGIGTPANVS
MUL_0965|M.ulcerans_Agy99           -----------------------------------SGDLNTGMGSPEDQS
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        PAIHIDFD------------------------------------------
Mb3380c|M.bovis_AF2122/97           PAIHIDFD------------------------------------------
MMAR_0642|M.marinum_M               GVSNIGTTLAGIFVDQASGMSTFSLGLADIGQANVGFGNTGDFNLGFANL
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        -----GAADAGFT-------------------------------------
Mb3380c|M.bovis_AF2122/97           -----GAADAGFT-------------------------------------
MMAR_0642|M.marinum_M               GDENLGLGNSGFNNLGLANLGNFNVGSANLGGYNIGSSNLGDYNVGFGNA
MUL_0965|M.ulcerans_Agy99           ------VANSGFR-------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        ------------------------------------------APATTLLS
Mb3380c|M.bovis_AF2122/97           ------------------------------------------ASATTLLS
MMAR_0642|M.marinum_M               GGFNQGLANSGNNNIGLFNTGNNNIGIGLTGDNQQGFNFGGGLNSGTGNT
MUL_0965|M.ulcerans_Agy99           -------------------------------------------NAGSGNS
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        ALGITGQFRFGPITVSNVQLNPFNVNLKLQFLHDAFPNEFPDPTISVQIQ
Mb3380c|M.bovis_AF2122/97           ALGITGQFRFGPITVSNVQLNPFNVNLKLQFLHDAFPNEFPDPTISVQIQ
MMAR_0642|M.marinum_M               GLFNSGTNNTGIFNSGTNNTGIFNSGNANWGIGNTGV-TNTGVFNSGQIN
MUL_0965|M.ulcerans_Agy99           GFNNTGSFSSGFFNSTNSNSEFLNAG--------------------GTVN
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          ------------------------------------------------SS
Mflv_0325|M.gilvum_PYR-GCK          ------------------------------------------FLLAVVYQ
Mvan_0415|M.vanbaalenii_PYR-1       ------------------------------------------FLAAVAYQ
MSMEG_0619|M.smegmatis_MC2_155      ------------------------------------------FLFGVAYQ
MAB_0669|M.abscessus_ATCC_1997      ------------------------------------------FLYDLLWY
TH_3113|M.thermoresistible__bu      -------------------------------------LSNPAYLFPVLVY
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        VAIPLTSATLGGLALPLQQTIDAIELPAISFSQSIPIDIPP---------
Mb3380c|M.bovis_AF2122/97           VAIPLTSATLGGLALPLQQTIDAIELPAISFSQSIPIDIPP---------
MMAR_0642|M.marinum_M               TGLWNAGNVNTGIGNPGNYNTGSFNTGSFNTAGLNPGDYNTGYLNSGNYN
MUL_0965|M.ulcerans_Agy99           SGINNSGNTNAGIGNLGDDNFGLFNNGTFNTG------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          AAAPQLWGGFAQHLSPINDTLSMINN------------------------
Mflv_0325|M.gilvum_PYR-GCK          A----VSWVGASILYPSLFLLPLLATT-----------------------
Mvan_0415|M.vanbaalenii_PYR-1       A----VSWVGASILYPSLLLLPLVATT-----------------------
MSMEG_0619|M.smegmatis_MC2_155      VFFNLVGWPTWGMIFASPFLIPALAALG----------------------
MAB_0669|M.abscessus_ATCC_1997      P---------YYASYLLPFLIPALSGLS----------------------
TH_3113|M.thermoresistible__bu      LLFTGVVHTTVAVSGMLAQLVPLMPALLPVAV------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        ------------IDIPASTINGISMS----EVVPIDVSVDIPAVTITGTR
Mb3380c|M.bovis_AF2122/97           ------------IDIPASTINGISMS----EVVPIDVSVDIPAVTITGTR
MMAR_0642|M.marinum_M               TGFANSGDVNTGAFISGNYSNGLLWRGDYQGLWGIDYAITIPDTAIPLNL
MUL_0965|M.ulcerans_Agy99           ---------------AGNSSGGAVFP------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        IDPIPLNFDVLSSAG-----------------------------------
Mb3380c|M.bovis_AF2122/97           IDPIPLNFDVLSSAG-----------------------------------
MMAR_0642|M.marinum_M               DVPVYLDIPITGTLGVFTVDGFTIPASTVELDIVGIGFKAVHVSAIKFPN
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        -----------------------------PINISIIDIPALPGFGNSTEL
Mb3380c|M.bovis_AF2122/97           -----------------------------PINISIIDIPALPGFGNSTEL
MMAR_0642|M.marinum_M               LELGLPAIDINIGTGPEPLIHIVGTGGLLPIKIPIIDIAAAPGFGNSTTT
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        PSSGFFNTGGGGGSGIANFGAGVSGLLNQASSPMVGTLSGLGNAGSLASG
Mb3380c|M.bovis_AF2122/97           PSSGFFNTGGGGGSGIANFGAGVSGLLNQASSPMVGTLSGLGNAGSLASG
MMAR_0642|M.marinum_M               ASSGFFNTGSGTASGFGNTGGNNSGFFNLASGSSG--ISGYQNLGDLVSG
MUL_0965|M.ulcerans_Agy99           YTSGLFNSGNGSS------------------------------------G
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          -----------------------------------------------LAI
Mvan_0415|M.vanbaalenii_PYR-1       -----------------------------------------------LAI
MSMEG_0619|M.smegmatis_MC2_155      ----------------------------------------------ITGL
MAB_0669|M.abscessus_ATCC_1997      ----------------------------------------------GLAA
TH_3113|M.thermoresistible__bu      ---------------------------------------------AALGG
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        VLNSGVDISGMFNVSTLG-SAPAVISGFGNLGNHVSGVSIDGLLAMLTSG
Mb3380c|M.bovis_AF2122/97           VLNSGVDISGMFNVSTLG-SAPAVISGFGNLGNHVSGVSIDGLLAMLTSG
MMAR_0642|M.marinum_M               MSNLGNSVSGFFNTSSLGVSIPADISGAANIGTNIAGFFNDNPIGNLGIA
MUL_0965|M.ulcerans_Agy99           VFNAGDEQSGFFGTSGLVLTGTDGLAATTTSGLPAL----DLPAPNLGIG
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          VAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPS
Mvan_0415|M.vanbaalenii_PYR-1       VLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPS
MSMEG_0619|M.smegmatis_MC2_155      VLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP-LAVGISPAGVPG
MAB_0669|M.abscessus_ATCC_1997      LMHLRPAAPGPVPA-AALSPGDRPIRRPTQHVEPNLAALPLPTSSVVPSG
TH_3113|M.thermoresistible__bu      LAGVWAGLSGLAGLAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPAPT
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        GSGGSGQPSIIDAAIAELRHLNPLNIVNLGNVGSYNLGFANVGDVNLGAG
Mb3380c|M.bovis_AF2122/97           GSGGSGQPSIIDAAIAELRHLNPLNIVNLGNVGSYNLGFANVGDVNLGAG
MMAR_0642|M.marinum_M               NLGNGN--------------------IGDGNIGSNNAGFGNVGANNFGSG
MUL_0965|M.ulcerans_Agy99           NAGVGN--------------------LGLGNIGDYNLGSGNTGDANFGSG
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          ------------------------------HAGMANAGLSLVNGMGSAMK
Mflv_0325|M.gilvum_PYR-GCK          GAPIAAN--------------------TVSAGSPPAPGAPAAAAATFVPY
Mvan_0415|M.vanbaalenii_PYR-1       SAAATVG--------------------TVATGTAPAPGAPAAATASFVPY
MSMEG_0619|M.smegmatis_MC2_155      SAATAAA--------------------PAPAPAGTTVAAPAPAAATFVPY
MAB_0669|M.abscessus_ATCC_1997      GSSVPVS--------------------TPTAPAHTVSSVPAPSAA--ISY
TH_3113|M.thermoresistible__bu      G-SAAPT--------------------TGTAPGGAGSPPPAGHSVPPAPH
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        NLGNLNLGGGNLGGQNLGLGNLGDGNVGFGNLGHGNVGFGNSGLG----A
Mb3380c|M.bovis_AF2122/97           NLGNLNLGGGNLGGQNLGLGNLGDGNVGFGNLGHGNVGFGNSGLG----A
MMAR_0642|M.marinum_M               NIGSFNFLSGNHGTYNFGLGNLGDYNVGLANLGDYNVGFGNAGSLNQGFA
MUL_0965|M.ulcerans_Agy99           NIGALNLGSGNHG-------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          SLAPT---------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          VVAGRDP-YEGFS-------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       AVAGRDP-GTGFS-------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      AVANRDP-GEGFT-------------------------------------
MAB_0669|M.abscessus_ATCC_1997      AIPGLVPPGVSFG-------------------------------------
TH_3113|M.thermoresistible__bu      SAPPVGTSGPPYL-------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        LPGIGNIGLGNAGSNNVGFG---------------NMGLGNIGFGNTGTN
Mb3380c|M.bovis_AF2122/97           LPGIGNIGLGNAGSNNVGFG---------------NMGLGNIGFGNTGTN
MMAR_0642|M.marinum_M               NTGDHNIGIGNTGNNNIGIGLTGDNQVGINLAGGLNSGTGNAGLFNSGTN
MUL_0965|M.ulcerans_Agy99           ---DANLGFGNTGDNNIGL-------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        NLGIGLTGDNQTGFGGLNSGAGNLGLFNSGTGNIGFFNTGTGNWGLFNSG
Mb3380c|M.bovis_AF2122/97           NLGIGLTGDNQTGFGGLNSGAGNLGLFNSGTGNIGFFNTGTGNWGLFNSG
MMAR_0642|M.marinum_M               NTGIFNSGTGNTGI--FNSGTANWGIGNSGTANSGIANSGSTNWGLWNPG
MUL_0965|M.ulcerans_Agy99           ----FNSGDNNVGF--FNSGGANFGLANSGDTNTGLWNAGSTNTGFGNAG
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          -----TTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSL
Mflv_0325|M.gilvum_PYR-GCK          -----PTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRG
Mvan_0415|M.vanbaalenii_PYR-1       -----PTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MSMEG_0619|M.smegmatis_MC2_155      -----PTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
MAB_0669|M.abscessus_ATCC_1997      -----PKSTEKSSESAVDTVAAVAAARGAVAAQARRRLRGKNKAEAGGR-
TH_3113|M.thermoresistible__bu      -----IAAQPAPGVARRSAGARRAASIVEPAGSAAAAAAARESAPIRRRR
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        SYNTGIGNSGTGSTGLFNAGSFNTGLANAGSYNTGSLNAGNTNTGGFNPG
Mb3380c|M.bovis_AF2122/97           SYNTGIGNSGTGSTGLFNAGSFNTGLANAGSYNTGSLNAGNTNTGGFNPG
MMAR_0642|M.marinum_M               TGNTGIANAGDYNTGLYNAGHTNTGLANPTDYNTGFFNTGDYNTGLANAG
MUL_0965|M.ulcerans_Agy99           SADFGFGNAGDRNMGFGNAGAANMGAGNSGSYNTGSFNSGTLNTGDFNGG
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          RVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGG
Mflv_0325|M.gilvum_PYR-GCK          YADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD-EQAGG
Mvan_0415|M.vanbaalenii_PYR-1       YADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA-AQAGG
MSMEG_0619|M.smegmatis_MC2_155      YADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD-VTAAG
MAB_0669|M.abscessus_ATCC_1997      -RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGFAGTAPAAASTHVAA
TH_3113|M.thermoresistible__bu      GQKDGLHGHRHEHQQPASMS-AATAPSAAGIRVLGGAGRISRTR-GSVPH
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        NVNTGWFNAGHTNTGGFNTGNVNTGAFNSGSFNNGALWTGDHHGLVGFSY
Mb3380c|M.bovis_AF2122/97           NVNTGWFNAGHTNTGGFNTGNVNTAAFNSGSFNNGALWTGDHHGLVGFSY
MMAR_0642|M.marinum_M               NYNTGFFNTGDYNTGLANTGDVNTGAFISGNYSNGMFWRGDYQGLVGAHY
MUL_0965|M.ulcerans_Agy99           DHNTGWGNSGNTNTGGINSGDLNT--------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          GSGTGGVNTALRLQPRAFVMPRNPAAG-----------------------
Mflv_0325|M.gilvum_PYR-GCK          LTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP---
Mvan_0415|M.vanbaalenii_PYR-1       LTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ---
MSMEG_0619|M.smegmatis_MC2_155      LTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPRR---
MAB_0669|M.abscessus_ATCC_1997      TVRLSSD--EARQVIPMLPSTWDAD-----------------GGDQN---
TH_3113|M.thermoresistible__bu      AEITPGDPTEPSSPTDRAHRPAEPN-------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        SIEITGSTLVDINETLNLGPVHIDQIDIPGMSLFDIHELVN----IGPFR
Mb3380c|M.bovis_AF2122/97           SIEITGSTLVDINETLNLGPVHIDQIDIPGMSLFDIHELVN----IGPFR
MMAR_0642|M.marinum_M               EIFIPEFPVLNFDLNIPVDIPIYLDLGSLALNGFTIPTITIDALSITDFK
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        IEPIDVP---AVVLDIHETMVIPPIVFLPSMTIGGQTYTIPLDTPPAPAP
Mb3380c|M.bovis_AF2122/97           IEPIDVP---AVVLDIHETMVIPPIVFLPSMTIGGQTYTIPLDTPPAPAP
MMAR_0642|M.marinum_M               IGPITIPTIKGILPVIDINIGNPDGSSSIPIAIRSGLGPISIVLLDIPAA
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        PPFRLPLLFVNALGDNWIVGASNSTGMSGGFVTAPTQGILIHTGPS----
Mb3380c|M.bovis_AF2122/97           PPFRLPLLFVNALGDNWIVGASNSTGMSGGFVTAPTQGILIHTGPS----
MMAR_0642|M.marinum_M               PGFGNSTSAPSSGFFNSGTGTASGFGNVGANNSGFWNTGFGDIGSSGLQN
MUL_0965|M.ulcerans_Agy99           -GFGSS--------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        --SATTGSLALTLPTVTIPTITTSPIPLKIDVSGGLPAFTLFPGGLNIPQ
Mb3380c|M.bovis_AF2122/97           --SATTGSLALTLPTVTIPTITTSPIPLKIDVSGGLPAFTLFPGGLNIPQ
MMAR_0642|M.marinum_M               YGQQLSGWANLGNTVSGWYNSSTADLPTAANLSGFFNIGTELSGVLRDSA
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        NAIP-LTIDASGVLDPITIFPGGFTIDPLP---LSLALNISVPDSSVPII
Mb3380c|M.bovis_AF2122/97           NAIP-LTIDASGVLDPITIFPGGFTIDPLP---LSLALNISVPDSSVPII
MMAR_0642|M.marinum_M               GTIFNAGLGDLGQLNLGSGNVGDFNVGSANIGSFNVGFGNVGADNLGSGN
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        IVPPTPGFGNATATPSSGFFN----SGAGGVSGFGNFGAGSSGWWNQAHA
Mb3380c|M.bovis_AF2122/97           IVPPTPGFGNATATPSSGFFN----SGAGGVSGFGNFGAGSSGWWNQAHA
MMAR_0642|M.marinum_M               IGSGNIGFGNAGAGLTEAFNNIGFGNVGDTNIGFGNTGNGNLGFGNTGNG
MUL_0965|M.ulcerans_Agy99           ------------------------ADQAVTNSGFGNNGSGNSGFNNTG--
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        ALAG--AGSGVLNVGTLNSGVLNVGSGISGLYNTAIVGLGTPALVSGAGN
Mb3380c|M.bovis_AF2122/97           ALAG--AGSGVLNVGTLNSGVLNVGSGISGLYNTAIVGLGTPALVSGAGN
MMAR_0642|M.marinum_M               NIGIGLSGDGQIGFGPLNDGVGNAGLFNLGDFNTGLANAGNDNQGW--SN
MUL_0965|M.ulcerans_Agy99           ------------------------------DTNSGFHNANTS--------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        VGQQLSGVLAAGTALTQSPIINLGLADVGNYNLGLGNVGDFNLGAANLGD
Mb3380c|M.bovis_AF2122/97           VGQQLSGVLAAGTALTQSPIINLGLADVGNYNLGLGNVGDFNLGAANLGD
MMAR_0642|M.marinum_M               TGNNNIGLFNTGDNNVGIGLTGDGRVGFGSLSSGAGNTGFFNSGTSNAGM
MUL_0965|M.ulcerans_Agy99           ------ALFS-------------------------GHSGLLNAG------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        LNLGLGNIGNANVGFGNIGHGNVGFGNSGLG-AALGIGNIGLGNAGSTNV
Mb3380c|M.bovis_AF2122/97           LNLGLGNIGNANVGFGNIGHGNVGFGNSGLG-RRS----------ASAIS
MMAR_0642|M.marinum_M               FNSGTGNVGFFNSGTGNVGIGNMGTGGIGIGLQGDNLVGIGGLNSGSFNV
MUL_0965|M.ulcerans_Agy99           -------------GSQSVGIN----------------------NTGSFNT
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        GLANMGVGNIGFANTGTNNLGIGLTGDNQTGIGGLNSGAGNIGLFNSGTG
Mb3380c|M.bovis_AF2122/97           GWAMRAAPTLAWP-------------------------------------
MMAR_0642|M.marinum_M               GLFNSGTGNVGIGNSGTG--------------------------------
MUL_0965|M.ulcerans_Agy99           VLFNTGFRTAGIANSATN--------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        NIGFFNSGTGNWGLFNSGSFNTGIGNSGTGSTGLFNAGGFTTGLANAGSY
Mb3380c|M.bovis_AF2122/97           ----------TWVWATSGSPTPAPTTSGLGWP-------ATTRPASAA--
MMAR_0642|M.marinum_M               ----------NWGIGNSGSHNSGIGNTGSYNTGLFNSGSFNTGIANPGNF
MUL_0965|M.ulcerans_Agy99           ----------GLLTATSGVANSGNNSSGGFN-------------ANPD--
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        NTGSFNVGDTNTGGFNPGSINTGWFNTGNANTGIANSGNVDTGALMSGNF
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               NTGLFNIGVFNTGIANPGDYNTGFYNTGDYNTGLANIGNFDTGAFITGNM
MUL_0965|M.ulcerans_Agy99           --------------------QSGFFN------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        SNGILWRGNYEGLFSYSYSLDVPRITILDAHFTGAFGPVVVPPIPVLAIN
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               ANGVFWRADSMGQLSAHYAITVNRIPAFMTIDAPVNIPITG---------
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        AHLTGNAAMGAFTIPQIDIPALNPNVTGSVGFGPIAVPSVTIPALTAARA
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               ------------TITDISIPAVTFPKVPATGKVDLAIISG----------
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        VLDMAASVGATSEIEPFIVWTSSGAIGPTWYSVGRIYNAGDLFVGGNIIS
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               --------------------------------------------------
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        GIPTLSTTGPVHAVFNAASQAFNTPALNIHQIPLGFQVPGSIDAITLFPG
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               ------------------------------------TVIAPIGPITIHGG
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        GLTFPANSLLNLDVFVGTPGATIPAITFPEIPANADGELYVIAGDIPLIN
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               DASAPLNTPIVIDFGTQPALQLNLGNPDGSTVVHVGGYFNFGPGQIPLID
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        IPPTPGIGNTTTVPSSGFFNTGAGGGSGFGNFGANMSGWWNQAHTALAGA
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               IKPAAGFFNATTGPSSGFFNLGDGSASGFANVGANNSGIWNVATAALG--
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        GSGIANVGTLHSGVLNLGSGLSGIYNTSTLPLGTPALVSGLGNVGDHLSG
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               NSGFQNIGSQQSGLANLGNAISGFLNTG---GATPANLSGFQNIGTDLAG
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        LLASNVGQNPITIVNIGLANVGNGNVGLGNIGNLNLGAANIGDVNLGFGN
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               WYRNGPDATTFSFG---IANPGFWNVGSANIGSYNLGNANIGVSNFGFGN
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        IGDVNLGFGNIGGGNVGFGNIGDANFGFGNSGLAAGLAGMGNIGLGNAGS
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               LGSANLGSANLGGFNLGSANIGSHNFGFANTGPALSDA-IGNIGFGNTGS
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        GNVGWANMGLGNIGFGNTGTNNLGIGLTGDNQSGIGGLNSGTGNIGLFNS
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               YNIGFGNTGNGNLGFANTGDGNIGIGLAGDTMTGFGGWNSGSGNIGLFNS
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        GTGNIGFFNSGTANFGLFNSGSYNTGIGNSGVASTGLVNAGGFNTGVANA
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               GTNNIGFGNSGTGNWGIGNSGSYNTGIGNTGTTNTGFFNSGMVNTGIGNA
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        G----------SYNTGSFNAGDTNTGGFNPGSTNTGWFNTGNANTGVANA
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               GNYNTGCYNTGDFNTGSFNPGDYNTGGFNPGNYNTGYFNEGNSNTGLANS
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        GNVNTGALITGNFSNGILWRGNYEGLAGFSFGYPIPLFPAVGADVTGDIG
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               GNVNTGAFISGNYSNGLLWRGDYQGLLGFTYESTVPAIPWNIGVHS----
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        PATIIPPIHIPSIPLGFAAIGHIGPISIPNIAIPSIHLGIDPTFDVGPIT
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               -------------DIDIPITGAINTITQDMFTIAEFEIPISLETTICLIY
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        VDPITLTIPGLSLDAAVSEIRMTSGSSSGFKVRPSFSFFAVGPDGMPGGE
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               VPFVGCVLH-----------------------------------------
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        VSILQPFTVAPINLNPTTLHFPGFTIPTGPIHIGLPLSLTIPGFTIPGGT
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               ---------VSVTVPITTEHVGPFVIDPSVINPQSPINTAIT--------
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        LIPQLPLGLGLSGGTPPFDLPTVVIDRIPVELHASTTIGPVSLPIFGFGG
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               ---------------------------DTIDFSDAGTVGPATFGFN-WQQ
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        APGFGNDTTAPSSGFFNTGGGGGSGFSNSGSGMSGVLN-------AISDP
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               SPGFFNSSDTPSSGFFNSGAGGASGLLNDAQGAVSGIGNAFLESSGFFNA
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        LLGSASGFANFGTQLSGILNRGAGISGVYNTGTLGLVTSAFVSGFMNVGQ
Mb3380c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_0642|M.marinum_M               GGPGLSGLQNVGTLESGWANFGNSLSGIYNTSILNLMAQAFVSGLGNTGH
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Rv3347c|M.tuberculosis_H37Rv        QLSGLLFAGTGP
Mb3380c|M.bovis_AF2122/97           ------------
MMAR_0642|M.marinum_M               ELSGFLNDAMA-
MUL_0965|M.ulcerans_Agy99           ------------
MAV_4704|M.avium_104                ------------
MLBr_01182|M.leprae_Br4923          ------------
Mflv_0325|M.gilvum_PYR-GCK          ------------
Mvan_0415|M.vanbaalenii_PYR-1       ------------
MSMEG_0619|M.smegmatis_MC2_155      ------------
MAB_0669|M.abscessus_ATCC_1997      ------------
TH_3113|M.thermoresistible__bu      ------------