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NHLTTLDAGFLKAEDVDRHVSLAIGALAVIEGPAPDQEAFLSSLAQRLRPCTRFGQRLRLRPFDLGAPKW VDDPDFDLGRHVWRIALPRPGNEDQLFELIADLMARRLDRGRPLWEVWVIEGLADSKWAILTKLHHCMAD GIAATHLLAGLSDESMSDSFASNIHTTMQSQSASVRRGGFRVNPSEALTASTAVMAGIVRAAKGASEIAA GVLSPAASSLNGPISDLRRYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRNVLIQRGERPRFDSLR TLVPVSTRSNSALSKTDNRVSLMLPNLPVDQENPLQRLRIVHSRLTRAKAGGQRQFGNTLMAIANRLPFP MTAWAVGLLMRLPQRGVVTVATNVPGPRRPLQIMGRRVLDLYPVSPIAMQLRTSVAMLSYADDLYFGILA DYDVVADAGQLARGIEDAVARLVAISKRRKVTRRRGALSLVV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3130c | - | - | 100% (463) | hypothetical protein Rv3130c |
| M. tuberculosis H37Rv | Rv3371 | - | 6e-97 | 44.97% (447) | hypothetical protein Rv3371 |
| M. tuberculosis H37Rv | Rv1425 | - | 4e-50 | 30.34% (468) | hypothetical protein Rv1425 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3154c | - | 0.0 | 100.00% (463) | hypothetical protein Mb3154c |
| M. gilvum PYR-GCK | Mflv_4977 | - | 1e-132 | 51.11% (452) | hypothetical protein Mflv_4977 |
| M. leprae Br4923 | MLBr_01244 | - | 5e-24 | 22.61% (398) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_3551c | - | 1e-54 | 31.98% (469) | hypothetical protein MAB_3551c |
| M. marinum M | MMAR_1519 | - | 1e-174 | 65.67% (466) | hypothetical protein MMAR_1519 |
| M. avium 104 | MAV_4336 | - | 6e-87 | 42.63% (441) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_5242 | - | 1e-129 | 52.80% (464) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. thermoresistible (build 8) | TH_2686 | - | 1e-54 | 32.41% (469) | PUTATIVE Diacylglycerol O-acyltransferase |
| M. ulcerans Agy99 | MUL_2420 | - | 1e-172 | 64.52% (465) | hypothetical protein MUL_2420 |
| M. vanbaalenii PYR-1 | Mvan_4104 | - | 1e-133 | 51.84% (463) | hypothetical protein Mvan_4104 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3130c|M.tuberculosis_H37Rv --------MNHLTTLDAG-----FLKAEDVDRHVSLAIGALAVIEGPAP-
Mb3154c|M.bovis_AF2122/97 --------MNHLTTLDAG-----FLKAEDVDRHVSLAIGALAVIEGPAP-
MMAR_1519|M.marinum_M --------MNHLTTLDSG-----FLKAEDVDPRVSLAIGGLAVIEGPVP-
MUL_2420|M.ulcerans_Agy99 --------MNHLTTLDSG-----FLKAEDVDPRVSLAIGGLAVIEGPVP-
Mflv_4977|M.gilvum_PYR-GCK --------MERMTAFDAG-----FLDAEDADRHVSLAVGAVSVVDGPMP-
Mvan_4104|M.vanbaalenii_PYR-1 --------MEHLSTLDAS-----FLQAEDSDPHVSLAVGAVSIIEGPAP-
MSMEG_5242|M.smegmatis_MC2_155 -----MTAPEQLSVLDAG-----FLEAEDSDPNVSLAIGAVAVMAGPMP-
MAV_4336|M.avium_104 ----------MAQTLDTA-----FLKAHDPDQHASLAIGAVAIVDGTVP-
MAB_3551c|M.abscessus_ATCC_199 MGKAARIVVSRLSALDAS-----FYSSEDS--ATPMHVGSLAIIRRPRGG
TH_2686|M.thermoresistible__bu -------MVTRLSASDAD-----FFHLEDT--STPMYVGSLAILRRPRGG
MLBr_01244|M.leprae_Br4923 ----MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTPD-
* : : . : .: :: .
Rv3130c|M.tuberculosis_H37Rv -DQEAFLSSLAQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWR
Mb3154c|M.bovis_AF2122/97 -DQEAFLSSLAQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWR
MMAR_1519|M.marinum_M -EQHDLVSVFSERIRACPRFAQRLRRYPFDLGAPQWVDDPDFDIARHVRR
MUL_2420|M.ulcerans_Agy99 -EQHDLVSVFSERIRACPRFAQRLRRYPFDLGAPQWVDDPDFDIARHVRR
Mflv_4977|M.gilvum_PYR-GCK -DFDEIVAAIGEKIVTIPRLRQVVRRQPLDLSAPEWVEDPTLDLAHHIRR
Mvan_4104|M.vanbaalenii_PYR-1 -DYDDLVAAFAERAQGIPRCTQIVHTRPFDLAAPEWVDDPHFDIAHHLHR
MSMEG_5242|M.smegmatis_MC2_155 -DFETLKATLAERILSVPRLRQVLHTRPLDLGAPEWVDDPHLDITRHIRR
MAV_4336|M.avium_104 -DPAQLEHLVAERILPIARCTQLLRAHPLNR---EWVDCPDFDLAWHLRR
MAB_3551c|M.abscessus_ATCC_199 FTYEELLALVESRLPQVPRYRQKVKEIGFGLARPVWLDDVDFDITYHIRR
TH_2686|M.thermoresistible__bu LSYETLLATVEQRLPQIPRYRQKVRKAPIGLARPVWVDDPDFDITYHVRR
MLBr_01244|M.leprae_Br4923 --WNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHVRR
: . . * * : : *: ::: *: *
Rv3130c|M.tuberculosis_H37Rv IALPRPGNEDQLFELIADLMARRLDRGRPLWEVWVIEGLADSKWAILTKL
Mb3154c|M.bovis_AF2122/97 IALPRPGNEDQLFELIADLMARRLDRGRPLWEVWVIEGLADSKWAILTKL
MMAR_1519|M.marinum_M VALPHPGDDDALHRLVADVMARRLDRDRPLWELWVIEGLAGERWAMLTKV
MUL_2420|M.ulcerans_Agy99 VALPHPGDDDALYRLVADVMGRRLDRDRPLWELWVIEGLAGERWAMLTKV
Mflv_4977|M.gilvum_PYR-GCK AALPHPGDDDALFRFTAEAMEPRLDRERPLWQAWIIEGLADDRWAILMKV
Mvan_4104|M.vanbaalenii_PYR-1 IALPAPGDDAEMFTTIAGIMERRLDRDRPLWECWIIEGLADGRWATLMKI
MSMEG_5242|M.smegmatis_MC2_155 AALPRPGDDAALHDWVAEVMERRLDRDHPLWQCWVADGLPANRWAILIKI
MAV_4336|M.avium_104 VAIAGTGDEAELSRVIGQALRRPLDPGRPPWECWVIEGLRGNRWAMLMKT
MAB_3551c|M.abscessus_ATCC_199 SALPSPGSDGQLQDLVARLTSRPLDRSRPLWEMYLVEGLSKNRLAIYTKT
TH_2686|M.thermoresistible__bu SALPSPGSDAQLHELIARLASRPLDKTRPLWEMYLIEGLAKNRLALYTKS
MLBr_01244|M.leprae_Br4923 VRVPDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLLQI
:. .* : :* :* * : :** : * :
Rv3130c|M.tuberculosis_H37Rv HHCMADGIAATHLLAGLSDESMSDSFASNIHTTMQSQSASVRRGGFRVN-
Mb3154c|M.bovis_AF2122/97 HHCMADGIAATHLLAGLSDESMSDSFASNIHTTMQSQSASVRRGGFRVN-
MMAR_1519|M.marinum_M HHCMADGIAVTHILTGLCDR-DGGGAADGSARCRAAQRPKTAAAHPRSG-
MUL_2420|M.ulcerans_Agy99 HHCMADGIAATHILTGLCDR-DGGGAADGSARCRAAQRPKTAAARPRSG-
Mflv_4977|M.gilvum_PYR-GCK HHCIADGIAAMHMLAGLSDDGEGETYAGAIRAAHEAGASRPALPSPTLNP
Mvan_4104|M.vanbaalenii_PYR-1 HHCIADGIATAQMLAKLSDDGAGETFAADIRAAQESGPSILGLLRPRLNP
MSMEG_5242|M.smegmatis_MC2_155 HHCVADGVAAAHLLTRLCDDSPEPSVPHAPPPAPRQAP-------FSLNP
MAV_4336|M.avium_104 HHGLLDGNPAARLITRLCDDADADMFANNAAAQPVSSP------------
MAB_3551c|M.abscessus_ATCC_199 HQALVDGNSALSLGQVIFDRTARTPDFGEDIWVPEHEPSTSELVAGAVSE
TH_2686|M.thermoresistible__bu HQALVNGMTAPEIGHVIADRTQKPPQFGEDIWMPGREPGTAQLLIGAIGD
MLBr_01244|M.leprae_Br4923 SHAITDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQGINH
: : :* : : *
Rv3130c|M.tuberculosis_H37Rv -----PSEALTASTAVMAGIVRAAKGASEIAAGVLS------------PA
Mb3154c|M.bovis_AF2122/97 -----PSEALTASTAVMAGIVRAAKGASEIAAGVLS------------PA
MMAR_1519|M.marinum_M -----LSGLWNAPAAIASGVVRLAQGAEELVTGLLT------------PA
MUL_2420|M.ulcerans_Agy99 -----LSGLWNAPAAIASGVVRLAQGSGELVTGLLT------------PV
Mflv_4977|M.gilvum_PYR-GCK V--RWARAGWNATTAVAATAAMTVEGAIGILSGLVR------------NA
Mvan_4104|M.vanbaalenii_PYR-1 L--DWMNGAWRATLAAAGAAEHAVVGAAELTARVLTP-----------GQ
MSMEG_5242|M.smegmatis_MC2_155 V--DWVTGAWRTAMDVTGIAGKVLHGAGEIVSGLLT------------PA
MAV_4336|M.avium_104 -------TGWLDALSRVSSLTGGLLGALRLAG------------------
MAB_3551c|M.abscessus_ATCC_199 W--LARPGARLEAVRNTVADVASLTGEIGELGERMVKVVR--TAARGAAP
TH_2686|M.thermoresistible__bu W--LTRPGAQMIAVRDNVLGMATNAGELVDAGRRALSVAR--TVARGTAP
MLBr_01244|M.leprae_Br4923 LPVALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQAAE
Rv3130c|M.tuberculosis_H37Rv ASSLNGPISDLRRYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRNV
Mb3154c|M.bovis_AF2122/97 ASSLNGPISDLRRYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRNV
MMAR_1519|M.marinum_M ASALTGPLSDLRRFSGARVPMADLELVCETFDVTINDVALAAITESYRNV
MUL_2420|M.ulcerans_Agy99 ASALTGPLSDLRRFSGARVPMADLELVCETFDVTINDVALAAITESYRNV
Mflv_4977|M.gilvum_PYR-GCK ESSLNGPVTTMRRYSAVQVPLATVASVCQAFDVTLNDVALAAITDSFRSA
Mvan_4104|M.vanbaalenii_PYR-1 ESSLNGPVTGMRRYSAAVVDLAVMKQVSRNFDVTLNDVALAAITNGYRHM
MSMEG_5242|M.smegmatis_MC2_155 PSSLTGPVTARRRFAAAEVSLADVARVCERFDVTVNDVALAAITASFRSM
MAV_4336|M.avium_104 ---RAEAVAPVRRYATVRVPIADVDRVCRKFGVSANDVALAAVTEGFRTV
MAB_3551c|M.abscessus_ATCC_199 RGPLNQRVSRSRRFGVVSTKLADYRRVRAKYDCDVNDVVLATIAGALRNW
TH_2686|M.thermoresistible__bu SSPLNTRVSRNRRFTVARHRLDDYRKVRARYDCDVNDVVLAVIAGALRNW
MLBr_01244|M.leprae_Br4923 PSPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALRRY
: * : . . **. ** :. . *
Rv3130c|M.tuberculosis_H37Rv LIQRGE-RPRFDSLRTLVPVSTRS-----NSALSKTDNRVSLMLPNLPVD
Mb3154c|M.bovis_AF2122/97 LIQRGE-RPRFDSLRTLVPVSTRS-----NSALSKTDNRVSLMLPNLPVD
MMAR_1519|M.marinum_M LLARGQ-QPQQGSLRTLVPVSVRA-----DNAFDKTDNRVSAMLPNLPVD
MUL_2420|M.ulcerans_Agy99 LLARGQ-QPQQGSLRTLVPVSVRA-----DNAFDKTDNRVSAMLPNLPVD
Mflv_4977|M.gilvum_PYR-GCK LKRRGE-EPRRDSLRTLVPVSVRS-----DDARDRLDNRVSVMLPHLPVD
Mvan_4104|M.vanbaalenii_PYR-1 LLDRGE-SPGPHALRTLVPVSMRS-----AGDFDVTDNRVSAMLPLLPVD
MSMEG_5242|M.smegmatis_MC2_155 LIARGV-APGPNALPTLVPVSVRPP----AGAGNDRANQVSVMLPNLPVD
MAV_4336|M.avium_104 LLDRGE-QPRADSLRTLVPLPVRS-----------------AVLSHLPVE
MAB_3551c|M.abscessus_ATCC_199 LMSRGEPVTTASTIRAMVPMSVYRDGDLDVGGEGAATTEVSPFLVDLPVG
TH_2686|M.thermoresistible__bu LLSRGEQVSSTATVRAMAPLSVQSDAELDSTAPGQAVSDVVPFLIDLPVG
MLBr_01244|M.leprae_Br4923 HEALGV---SISTLPMAVPVNVRT------EADVVGSNRFVGVTLAAPLG
* :: .*: . *:
Rv3130c|M.tuberculosis_H37Rv QENPLQRLRIVHSRLTRAKAGGQRQFGNTLMAIANRLPFPMTAWAVGLLM
Mb3154c|M.bovis_AF2122/97 QENPLQRLRIVHSRLTRAKAGGQRQFGNTLMAIANRLPFPMTAWAVGLLM
MMAR_1519|M.marinum_M EEDPVQRLRKVHARLGQTKASGQPQAGNLFLSLADRIPFALTAWTVGVLM
MUL_2420|M.ulcerans_Agy99 EEDPVQRLRKVHARLGQTKASGQPRAGNLFLSLADRIPFALTAWTVGVLM
Mflv_4977|M.gilvum_PYR-GCK EPDPVEQLRTVHRRLNRAKSSGQRQAGTAAVAAVKLIPFALATRAIRAVT
Mvan_4104|M.vanbaalenii_PYR-1 EPDPVRQLEIVHRRLSRAKGSGQREGGDAVLAAAGNIPFALSAWTIRLLT
MSMEG_5242|M.smegmatis_MC2_155 QADPVAQLQAVHTRLSKAKASGQRQAGSALVTMAAAVPFPLTAWAVRALT
MAV_4336|M.avium_104 HDDPVRRLQTVHARCN--PAAGTQPAG-IVESAIGLVPNMVRGNLIQLLS
MAB_3551c|M.abscessus_ATCC_199 EGNTVVRLSQIAHATESHSAAFSLVDVPNMAALSGFVPPTLHALAARVAS
TH_2686|M.thermoresistible__bu ERNPVVRLSQISHATETHPTASSLVDARTIVTLTGFAPATLHAMGVRVAT
MLBr_01244|M.leprae_Br4923 TNDPAARMQKIRSQMTQRRDEPAMNIIGSLAPLMTVLPASVLDFIVDSVA
:. :: : . * :
Rv3130c|M.tuberculosis_H37Rv RLPQRGVVTVATNVPGPRRPLQIMGRRVLDLYPVSPIAMQLRTSVAMLSY
Mb3154c|M.bovis_AF2122/97 RLPQRGVVTVATNVPGPRRPLQIMGRRVLDLYPVSPIAMQLRTSVAMLSY
MMAR_1519|M.marinum_M RLPQRGVATVATNVPGPRQPLQIMGRPVAAVFPVPPLAMHLRTGVAMLSY
MUL_2420|M.ulcerans_Agy99 RLPQRGVATVATNVPGPRQPLQIMGRPVAAVFPVPPLAMHLRTGVAMLSY
Mflv_4977|M.gilvum_PYR-GCK SLPQHGVVTLATNVPGPQHRLQVMGREVVRMFPVPPMALRLRTAVAILSY
Mvan_4104|M.vanbaalenii_PYR-1 RLPQRSVTALATNVPGPRGRQRVLGRKVVEILPIPPIALHLRTGIAMLSY
MSMEG_5242|M.smegmatis_MC2_155 RLPQRGVAMLATNVPGPRRRVTILGREVIRLLPVPPIAMRMRTAVAILSY
MAV_4336|M.avium_104 RLPQRAVVTLATNVPGPRRRLRVMGQTLERLLPVPPTATQLHTGVAVLSY
MAB_3551c|M.abscessus_ATCC_199 TLPNRLFNLLVTNVPGPQAPMYLGGARLAEIYPVPPLLRNQVLSIGLTSY
TH_2686|M.thermoresistible__bu NFSARQFNLLITNVPGAQKQMYIAGTKMLESYSVPPLLRNQVLAVAVTSY
MLBr_01244|M.leprae_Br4923 SSDVN-----ASNIPAYPGDTYFAGAKILRQYGIGPRPG-VAMMAVLMSR
. :*:*. . * : : * : *
Rv3130c|M.tuberculosis_H37Rv ADDLYFGILADYDVVADAGQLARGIEDAVARLVAISK--------RRKVT
Mb3154c|M.bovis_AF2122/97 ADDLYFGILADYDVVADAGQLARGIEDAVARLVAISK--------RRKVT
MMAR_1519|M.marinum_M SDDLYFGILTDYNAVADVDQLARGIEAAVARLVAISK--------RRKAR
MUL_2420|M.ulcerans_Agy99 SDDLYFGILTDYNPVADVDQLARGTEAAVARLVAISK--------RRKAR
Mflv_4977|M.gilvum_PYR-GCK GDDLVFGITTDFDAFPDVDELAAGIGAAVDTLAAAAR--------PL---
Mvan_4104|M.vanbaalenii_PYR-1 AGRFSFGITADYDSAPDVDALARGIGEGVRCLAELGR--------AERRT
MSMEG_5242|M.smegmatis_MC2_155 ADHLAFGIISDYDAEIDVDAVAAGIEQAVARLAQIAV--------AHIRS
MAV_4336|M.avium_104 GDELVFGITAGPGDGFDVTRLAAAVELGMARLAALGDDSVLLFADRRRRR
MAB_3551c|M.abscessus_ATCC_199 NGTVYYGINADREAMPDADMLPLLITEALDELLEAAQ-------------
TH_2686|M.thermoresistible__bu HGMLYYGVNADRDAMSDVEVLPSLLSESLDELLEAAQ-------------
MLBr_01244|M.leprae_Br4923 GGFCTVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAA
. : . . .. .. : .
Rv3130c|M.tuberculosis_H37Rv RRRGALSLVV------------
Mb3154c|M.bovis_AF2122/97 RRRGALSLVV------------
MMAR_1519|M.marinum_M RARGPLSLVV------------
MUL_2420|M.ulcerans_Agy99 RGRGPLSLVV------------
Mflv_4977|M.gilvum_PYR-GCK ----------------------
Mvan_4104|M.vanbaalenii_PYR-1 PPDGAGRPIADAP---------
MSMEG_5242|M.smegmatis_MC2_155 TPLGTLALVPGELA--------
MAV_4336|M.avium_104 AARSPLGRVPPAHPSAPGHARH
MAB_3551c|M.abscessus_ATCC_199 ----------------------
TH_2686|M.thermoresistible__bu ----------------------
MLBr_01244|M.leprae_Br4923 RSSGSPAGWLSSS---------