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EHLSTLDASFLQAEDSDPHVSLAVGAVSIIEGPAPDYDDLVAAFAERAQGIPRCTQIVHTRPFDLAAPEW VDDPHFDIAHHLHRIALPAPGDDAEMFTTIAGIMERRLDRDRPLWECWIIEGLADGRWATLMKIHHCIAD GIATAQMLAKLSDDGAGETFAADIRAAQESGPSILGLLRPRLNPLDWMNGAWRATLAAAGAAEHAVVGAA ELTARVLTPGQESSLNGPVTGMRRYSAAVVDLAVMKQVSRNFDVTLNDVALAAITNGYRHMLLDRGESPG PHALRTLVPVSMRSAGDFDVTDNRVSAMLPLLPVDEPDPVRQLEIVHRRLSRAKGSGQREGGDAVLAAAG NIPFALSAWTIRLLTRLPQRSVTALATNVPGPRGRQRVLGRKVVEILPIPPIALHLRTGIAMLSYAGRFS FGITADYDSAPDVDALARGIGEGVRCLAELGRAERRTPPDGAGRPIADAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4104 | - | - | 100% (471) | hypothetical protein Mvan_4104 |
| M. vanbaalenii PYR-1 | Mvan_1764 | - | 2e-50 | 31.28% (470) | hypothetical protein Mvan_1764 |
| M. vanbaalenii PYR-1 | Mvan_3601 | - | 2e-42 | 30.40% (477) | hypothetical protein Mvan_3601 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3154c | - | 1e-133 | 51.84% (463) | hypothetical protein Mb3154c |
| M. gilvum PYR-GCK | Mflv_2541 | - | 0.0 | 84.47% (470) | hypothetical protein Mflv_2541 |
| M. tuberculosis H37Rv | Rv3130c | tgs1 | 1e-133 | 51.84% (463) | triacylglycerol synthase |
| M. leprae Br4923 | MLBr_01244 | - | 3e-25 | 25.27% (459) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_3551c | - | 5e-54 | 32.42% (475) | hypothetical protein MAB_3551c |
| M. marinum M | MMAR_3406 | - | 1e-169 | 63.32% (458) | hypothetical protein MMAR_3406 |
| M. avium 104 | MAV_4336 | - | 2e-87 | 41.83% (447) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_5242 | - | 1e-141 | 54.11% (462) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. thermoresistible (build 8) | TH_2686 | - | 1e-53 | 31.91% (470) | PUTATIVE Diacylglycerol O-acyltransferase |
| M. ulcerans Agy99 | MUL_2420 | - | 1e-130 | 52.15% (466) | hypothetical protein MUL_2420 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3154c|M.bovis_AF2122/97 --------MNHLTTLDAG-----FLKAEDVDRHVSLAIGALAVIEGPAP-
Rv3130c|M.tuberculosis_H37Rv --------MNHLTTLDAG-----FLKAEDVDRHVSLAIGALAVIEGPAP-
MUL_2420|M.ulcerans_Agy99 --------MNHLTTLDSG-----FLKAEDVDPRVSLAIGGLAVIEGPVP-
Mvan_4104|M.vanbaalenii_PYR-1 --------MEHLSTLDAS-----FLQAEDSDPHVSLAVGAVSIIEGPAP-
Mflv_2541|M.gilvum_PYR-GCK --------MQHLTTLDAS-----FLQAEDSDPHVSLAVGAVSIIEGPQP-
MMAR_3406|M.marinum_M --------MEHLTPLDAT-----FLEVEDSDPHVSLAIGGVSIVEGPAP-
MSMEG_5242|M.smegmatis_MC2_155 -----MTAPEQLSVLDAG-----FLEAEDSDPNVSLAIGAVAVMAGPMP-
MAV_4336|M.avium_104 ----------MAQTLDTA-----FLKAHDPDQHASLAIGAVAIVDGTVP-
MAB_3551c|M.abscessus_ATCC_199 MGKAARIVVSRLSALDAS-----FYSSEDS--ATPMHVGSLAIIRRPRGG
TH_2686|M.thermoresistible__bu -------MVTRLSASDAD-----FFHLEDT--STPMYVGSLAILRRPRGG
MLBr_01244|M.leprae_Br4923 ----MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTPD-
* : : . : .: :: .
Mb3154c|M.bovis_AF2122/97 -DQEAFLSSLAQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWR
Rv3130c|M.tuberculosis_H37Rv -DQEAFLSSLAQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWR
MUL_2420|M.ulcerans_Agy99 -EQHDLVSVFSERIRACPRFAQRLRRYPFDLGAPQWVDDPDFDIARHVRR
Mvan_4104|M.vanbaalenii_PYR-1 -DYDDLVAAFAERAQGIPRCTQIVHTRPFDLAAPEWVDDPHFDIAHHLHR
Mflv_2541|M.gilvum_PYR-GCK -DYHELIEVFAERAHRIPRCTQIVRMRPFDLAAPEWVDDPYFDIGHHLHR
MMAR_3406|M.marinum_M -AFGEFVDSFAERASAIPRFKQILRTHPLDLGSPEWVADPHFDVSRHVHH
MSMEG_5242|M.smegmatis_MC2_155 -DFETLKATLAERILSVPRLRQVLHTRPLDLGAPEWVDDPHLDITRHIRR
MAV_4336|M.avium_104 -DPAQLEHLVAERILPIARCTQLLRAHPLNR---EWVDCPDFDLAWHLRR
MAB_3551c|M.abscessus_ATCC_199 FTYEELLALVESRLPQVPRYRQKVKEIGFGLARPVWLDDVDFDITYHIRR
TH_2686|M.thermoresistible__bu LSYETLLATVEQRLPQIPRYRQKVRKAPIGLARPVWVDDPDFDITYHVRR
MLBr_01244|M.leprae_Br4923 --WNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHVRR
: . . * * : : *: ::: *: :
Mb3154c|M.bovis_AF2122/97 IALPRPGNEDQLFELIADLMARRLDRGRPLWEVWVIEGLADSKWAILTKL
Rv3130c|M.tuberculosis_H37Rv IALPRPGNEDQLFELIADLMARRLDRGRPLWEVWVIEGLADSKWAILTKL
MUL_2420|M.ulcerans_Agy99 VALPHPGDDDALYRLVADVMGRRLDRDRPLWELWVIEGLAGERWAMLTKV
Mvan_4104|M.vanbaalenii_PYR-1 IALPAPGDDAEMFTTIAGIMERRLDRDRPLWECWIIEGLADGRWATLMKI
Mflv_2541|M.gilvum_PYR-GCK VAVPAPGADAELFAMIATIMERRLDRDRPLWECWIIEGLAGGRWATLIKI
MMAR_3406|M.marinum_M LALPQPGGDAELFEMIATVMERRLDRDRPLWECYLIEGLSDDRWAVLTKL
MSMEG_5242|M.smegmatis_MC2_155 AALPRPGDDAALHDWVAEVMERRLDRDHPLWQCWVADGLPANRWAILIKI
MAV_4336|M.avium_104 VAIAGTGDEAELSRVIGQALRRPLDPGRPPWECWVIEGLRGNRWAMLMKT
MAB_3551c|M.abscessus_ATCC_199 SALPSPGSDGQLQDLVARLTSRPLDRSRPLWEMYLVEGLSKNRLAIYTKT
TH_2686|M.thermoresistible__bu SALPSPGSDAQLHELIARLASRPLDKTRPLWEMYLIEGLAKNRLALYTKS
MLBr_01244|M.leprae_Br4923 VRVPDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLLQI
:. .* : :* :* * : :** : * :
Mb3154c|M.bovis_AF2122/97 HHCMADGIAATHLLAGLSDES--MSDSFASNIHTTMQSQSASVRRG----
Rv3130c|M.tuberculosis_H37Rv HHCMADGIAATHLLAGLSDES--MSDSFASNIHTTMQSQSASVRRG----
MUL_2420|M.ulcerans_Agy99 HHCMADGIAATHILTGLCDRDGGGAADGSARCRAAQRPKTAAARP-----
Mvan_4104|M.vanbaalenii_PYR-1 HHCIADGIATAQMLAKLSDD--GAGETFAADIRAAQESGPSILGL-LRPR
Mflv_2541|M.gilvum_PYR-GCK HHCIADGIATAQMLAKLSDD--GAGETFAADIRAARESGSSIVGL-LRPR
MMAR_3406|M.marinum_M HHCIADGIATTQMLAKFGDES-GGGGSFATEIRAAKEPAPHGPGLPVKVS
MSMEG_5242|M.smegmatis_MC2_155 HHCVADGVAAAHLLTRLCDD------SPEPSVPHAPPPAPRQAPF----S
MAV_4336|M.avium_104 HHGLLDGNPAARLITRLCDDA--DADMFANNAAAQPVSSP----------
MAB_3551c|M.abscessus_ATCC_199 HQALVDGNSALSLGQVIFDRTARTPDFGEDIWVPEHEPSTSELVAG----
TH_2686|M.thermoresistible__bu HQALVNGMTAPEIGHVIADRTQKPPQFGEDIWMPGREPGTAQLLIG----
MLBr_01244|M.leprae_Br4923 SHAITDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQG-IN
: : :* : : : *
Mb3154c|M.bovis_AF2122/97 -GFRVNPSEALTASTAVMAGIVRAAKGASEIAAG-----------VLSPA
Rv3130c|M.tuberculosis_H37Rv -GFRVNPSEALTASTAVMAGIVRAAKGASEIAAG-----------VLSPA
MUL_2420|M.ulcerans_Agy99 ---RSGLSGLWNAPAAIASGVVRLAQGSGELVTG-----------LLTPV
Mvan_4104|M.vanbaalenii_PYR-1 LNPLDWMNGAWRATLAAAGAAEHAVVGAAELTAR-----------VLTPG
Mflv_2541|M.gilvum_PYR-GCK LNPVAWMSGAWRATLTAGSAAEHAIVGAAELTAR-----------VLAPG
MMAR_3406|M.marinum_M LNPLNWVTGIVRGALGAVSVVEHVALGAAELTGS-----------LLSPA
MSMEG_5242|M.smegmatis_MC2_155 LNPVDWVTGAWRTAMDVTGIAGKVLHGAGEIVSG-----------LLTPA
MAV_4336|M.avium_104 --------TGWLDALSRVSSLTGGLLGALRLAGR-----------AEAVA
MAB_3551c|M.abscessus_ATCC_199 -AVSEWLARPGARLEAVRNTVADVASLTGEIGELGERMVKVVRTAARGAA
TH_2686|M.thermoresistible__bu -AIGDWLTRPGAQMIAVRDNVLGMATNAGELVDAGRRALSVARTVARGTA
MLBr_01244|M.leprae_Br4923 HLPVALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQAA
.
Mb3154c|M.bovis_AF2122/97 A-SSLNGPISDLRRYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRN
Rv3130c|M.tuberculosis_H37Rv A-SSLNGPISDLRRYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRN
MUL_2420|M.ulcerans_Agy99 A-SALTGPLSDLRRFSGARVPMADLELVCETFDVTINDVALAAITESYRN
Mvan_4104|M.vanbaalenii_PYR-1 QESSLNGPVTGMRRYSAAVVDLAVMKQVSRNFDVTLNDVALAAITNGYRH
Mflv_2541|M.gilvum_PYR-GCK QESSLNGPVTGMRRFSAATVDLGVMKDVSRHFGVTLNDVALAAITSGYRN
MMAR_3406|M.marinum_M PETSLSGPVTTLRRFSVARVRLSDLHTVARAFDVTLNDVALAAITSSYRS
MSMEG_5242|M.smegmatis_MC2_155 P-SSLTGPVTARRRFAAAEVSLADVARVCERFDVTVNDVALAAITASFRS
MAV_4336|M.avium_104 P----------VRRYATVRVPIADVDRVCRKFGVSANDVALAAVTEGFRT
MAB_3551c|M.abscessus_ATCC_199 PRGPLNQRVSRSRRFGVVSTKLADYRRVRAKYDCDVNDVVLATIAGALRN
TH_2686|M.thermoresistible__bu PSSPLNTRVSRNRRFTVARHRLDDYRKVRARYDCDVNDVVLAVIAGALRN
MLBr_01244|M.leprae_Br4923 EPSPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALRR
* : . . **. ** :. . *
Mb3154c|M.bovis_AF2122/97 VLIQRGE-RPRFDSLRTLVPVSTRS-----NSALSKTDNRVSLMLPNLPV
Rv3130c|M.tuberculosis_H37Rv VLIQRGE-RPRFDSLRTLVPVSTRS-----NSALSKTDNRVSLMLPNLPV
MUL_2420|M.ulcerans_Agy99 VLLARGQ-QPQQGSLRTLVPVSVRA-----DNAFDKTDNRVSAMLPNLPV
Mvan_4104|M.vanbaalenii_PYR-1 MLLDRGE-SPGPHALRTLVPVSMRS-----AGDFDVTDNRVSAMLPLLPV
Mflv_2541|M.gilvum_PYR-GCK MLLARGE-SPGPRTLRTLVPVSMRS-----ASDFDVTDNRVSAMLPLLPV
MMAR_3406|M.marinum_M ILLERGE-KPGHTSLRTLVPVSVRG-----MSHFNMTDNQVSAMLPLLPV
MSMEG_5242|M.smegmatis_MC2_155 MLIARGV-APGPNALPTLVPVSVRPP----AGAGNDRANQVSVMLPNLPV
MAV_4336|M.avium_104 VLLDRGE-QPRADSLRTLVPLPVRS-----------------AVLSHLPV
MAB_3551c|M.abscessus_ATCC_199 WLMSRGEPVTTASTIRAMVPMSVYRDGDLDVGGEGAATTEVSPFLVDLPV
TH_2686|M.thermoresistible__bu WLLSRGEQVSSTATVRAMAPLSVQSDAELDSTAPGQAVSDVVPFLIDLPV
MLBr_01244|M.leprae_Br4923 YHEALGV---SISTLPMAVPVNVRT------EADVVGSNRFVGVTLAAPL
* :: .*: . *:
Mb3154c|M.bovis_AF2122/97 DQENPLQRLRIVHSRLTRAKAGGQRQFGNTLMAIANRLPFPMTAWAVGLL
Rv3130c|M.tuberculosis_H37Rv DQENPLQRLRIVHSRLTRAKAGGQRQFGNTLMAIANRLPFPMTAWAVGLL
MUL_2420|M.ulcerans_Agy99 DEEDPVQRLRKVHARLGQTKASGQPRAGNLFLSLADRIPFALTAWTVGVL
Mvan_4104|M.vanbaalenii_PYR-1 DEPDPVRQLEIVHRRLSRAKGSGQREGGDAVLAAAGNIPFALSAWTIRLL
Mflv_2541|M.gilvum_PYR-GCK DEPDPVRQLDIVHRRLLRAKGSGQREGGTAVFAAAGNIPFALSAWTIRFL
MMAR_3406|M.marinum_M DEEDPVKQLELVHRRLVEAKASGQREGGTALVAAAKSAPFAFSAWAVRLL
MSMEG_5242|M.smegmatis_MC2_155 DQADPVAQLQAVHTRLSKAKASGQRQAGSALVTMAAAVPFPLTAWAVRAL
MAV_4336|M.avium_104 EHDDPVRRLQTVHARCN--PAAGTQPAG-IVESAIGLVPNMVRGNLIQLL
MAB_3551c|M.abscessus_ATCC_199 GEGNTVVRLSQIAHATESHSAAFSLVDVPNMAALSGFVPPTLHALAARVA
TH_2686|M.thermoresistible__bu GERNPVVRLSQISHATETHPTASSLVDARTIVTLTGFAPATLHAMGVRVA
MLBr_01244|M.leprae_Br4923 GTNDPAARMQKIRSQMTQRRDEPAMNIIGSLAPLMTVLPASVLDFIVDSV
:. :: : . . * .
Mb3154c|M.bovis_AF2122/97 MRLPQRGVVTVATNVPGPRRPLQIMGRRVLDLYPVSPIAMQLRTSVAMLS
Rv3130c|M.tuberculosis_H37Rv MRLPQRGVVTVATNVPGPRRPLQIMGRRVLDLYPVSPIAMQLRTSVAMLS
MUL_2420|M.ulcerans_Agy99 MRLPQRGVATVATNVPGPRQPLQIMGRPVAAVFPVPPLAMHLRTGVAMLS
Mvan_4104|M.vanbaalenii_PYR-1 TRLPQRSVTALATNVPGPRGRQRVLGRKVVEILPIPPIALHLRTGIAMLS
Mflv_2541|M.gilvum_PYR-GCK TRLPQKSVTALATNVPGPRGRQRVLGRKVVEILPIPPIALHLRTGIAMLS
MMAR_3406|M.marinum_M SRLPQRAVVALATNVPGPRAEQKLMGRRVLEMLPIPPIALNLRTGVAMVS
MSMEG_5242|M.smegmatis_MC2_155 TRLPQRGVAMLATNVPGPRRRVTILGREVIRLLPVPPIAMRMRTAVAILS
MAV_4336|M.avium_104 SRLPQRAVVTLATNVPGPRRRLRVMGQTLERLLPVPPTATQLHTGVAVLS
MAB_3551c|M.abscessus_ATCC_199 STLPNRLFNLLVTNVPGPQAPMYLGGARLAEIYPVPPLLRNQVLSIGLTS
TH_2686|M.thermoresistible__bu TNFSARQFNLLITNVPGAQKQMYIAGTKMLESYSVPPLLRNQVLAVAVTS
MLBr_01244|M.leprae_Br4923 ASSDVN-----ASNIPAYPGDTYFAGAKILRQYGIGPRPG-VAMMAVLMS
. :*:*. . * : : * : *
Mb3154c|M.bovis_AF2122/97 YADDLYFGILADYDVVADAGQLARGIEDAVARLVAI--------SKRRKV
Rv3130c|M.tuberculosis_H37Rv YADDLYFGILADYDVVADAGQLARGIEDAVARLVAI--------SKRRKV
MUL_2420|M.ulcerans_Agy99 YSDDLYFGILTDYNPVADVDQLARGTEAAVARLVAI--------SKRRKA
Mvan_4104|M.vanbaalenii_PYR-1 YAGRFSFGITADYDSAPDVDALARGIGEGVRCLAEL--------GRA-ER
Mflv_2541|M.gilvum_PYR-GCK YARRFSFGITADYDTAPDVDTLARGIENGVQCLADL--------CGV-GR
MMAR_3406|M.marinum_M YGDNFVFGITADYDTAPDIEVLAAGIEDGVARLVKE--------SRG-KR
MSMEG_5242|M.smegmatis_MC2_155 YADHLAFGIISDYDAEIDVDAVAAGIEQAVARLAQI--------AVAHIR
MAV_4336|M.avium_104 YGDELVFGITAGPGDGFDVTRLAAAVELGMARLAALGDDSVLLFADRRRR
MAB_3551c|M.abscessus_ATCC_199 YNGTVYYGINADREAMPDADMLPLLITEALDELLEAAQ------------
TH_2686|M.thermoresistible__bu YHGMLYYGVNADRDAMSDVEVLPSLLSESLDELLEAAQ------------
MLBr_01244|M.leprae_Br4923 RGGFCTVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFA
: . . .. .. :
Mb3154c|M.bovis_AF2122/97 TRRRGALSLVV------------
Rv3130c|M.tuberculosis_H37Rv TRRRGALSLVV------------
MUL_2420|M.ulcerans_Agy99 RRGRGPLSLVV------------
Mvan_4104|M.vanbaalenii_PYR-1 RTPPDGAGRPIADAP--------
Mflv_2541|M.gilvum_PYR-GCK GPGSGVPARPNAEAANNKNPA--
MMAR_3406|M.marinum_M GSAAG------------------
MSMEG_5242|M.smegmatis_MC2_155 STPLGTLALVPGELA--------
MAV_4336|M.avium_104 RAARSPLGRVPPAHPSAPGHARH
MAB_3551c|M.abscessus_ATCC_199 -----------------------
TH_2686|M.thermoresistible__bu -----------------------
MLBr_01244|M.leprae_Br4923 ARSSGSPAGWLSSS---------