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RSWWGWGTVEDALSDQETQALQSRVAALVSGHDLSDHPPPDLTALGLAAPRVSPPASLAALCSSDLVDRA GHARGKAYRDIARNLQGQLDHLPDLIARPRSEQDVIDVLDWCAREGIAVIPYGGGSSVVGGVEPRFDEPV VTVDVTAMSAVLEIDRVSRAARIQAGAFGPSIEHQLRPHDLTLRHFPQSFGFSTLGGWLATRSGGHFATL YTHIDDLTESLRIVTPVGISESRRLPGSGAGPSPDRLFLGSEGTLGIITEAWMRLQHRPRWQVTVSVVFD DWAAAVAATRTIAQAGLYPANCRLLDPAEALLNAGTSVGGGLLVLAFESADHPIDPWLHRAVAITAEHGG TVTAQRSRGTTSDATEHNAAANWRSAFLRMPYQRDALVRRGVIAETFETACTWDGFDTLHAAVTDAARTA IWKVCGTGVVTCRFTHVYPDGPAPYYGIYAGGRWGSLDAQWDEIKAAVSEAISASGGTITHHHAVGRDHR AWYDRQRPDPFAAALRAAKSALDPAGILNPGVLLGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3107c | agpS | - | 100% (527) | POSSIBLE ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE AGPS (ALKYL-DHAP SYNTHASE) (ALKYLGLYCERONE-PHOSPHATE SYNTHASE) |
| M. tuberculosis H37Rv | Rv2251 | - | 2e-82 | 39.73% (438) | flavoprotein |
| M. tuberculosis H37Rv | Rv0161 | - | 3e-21 | 25.27% (471) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3134c | agpS | 0.0 | 100.00% (527) | alkyldihydroxyacetonephosphate synthase AgpS |
| M. gilvum PYR-GCK | Mflv_2772 | - | 8e-81 | 36.35% (542) | alkylglycerone-phosphate synthase |
| M. leprae Br4923 | MLBr_01103 | - | 2e-23 | 26.92% (442) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_3884 | - | 2e-76 | 34.93% (544) | flavoprotein |
| M. marinum M | MMAR_1525 | agpS | 0.0 | 81.51% (530) | alkyldihydroxyacetonephosphate synthase AgpS |
| M. avium 104 | MAV_2186 | - | 1e-84 | 36.85% (540) | flavoprotein |
| M. smegmatis MC2 155 | MSMEG_4334 | - | 6e-84 | 36.99% (538) | flavoprotein |
| M. thermoresistible (build 8) | TH_1507 | - | 1e-84 | 37.82% (476) | flavoprotein |
| M. ulcerans Agy99 | MUL_1298 | - | 2e-77 | 35.97% (467) | flavoprotein |
| M. vanbaalenii PYR-1 | Mvan_3761 | - | 4e-85 | 37.57% (543) | alkylglycerone-phosphate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3107c|M.tuberculosis_H37Rv ----------MRSWWGWGTVEDALSDQETQALQSRVAALVSGHDLSDHPP
Mb3134c|M.bovis_AF2122/97 ----------MRSWWGWGTVEDALSDQETQALQSRVAALVSGHDLSDHPP
MMAR_1525|M.marinum_M ----------MRSWWGWGNVEDALTEAETHALLSRVSALLPGHDLSDHQP
Mflv_2772|M.gilvum_PYR-GCK ----------MMQWNAWGDPDAAKPLSPGIRSLLHQALGIDGTPLDEPTL
Mvan_3761|M.vanbaalenii_PYR-1 ----------MMQWNAWGDPAAAKPLSPAIRALLGQALGIDGADIDEPTL
MSMEG_4334|M.smegmatis_MC2_155 -----------MKWNAWGDPQAAKPLSDGIRALLQQALGVTDSP-AQISP
TH_1507|M.thermoresistible__bu MSAPENHLSPPMKWNAWGDPAAARPLSDGIRSLLREALGVEGPPTPDLSP
MAV_2186|M.avium_104 -MTHPERLLPPMKWNAWGDPAAAKPLSEGIRSLLQQAVGIEGSRAAEPRP
MUL_1298|M.ulcerans_Agy99 -----------MKWNAWGDPAAAKPLSDGIRALLKQVVGLEDSDEAELGA
MAB_3884|M.abscessus_ATCC_1997 ----------MMEWDAWGVAEKRQTLSPQVKALLASALGIPEREPVHRDE
MLBr_01103|M.leprae_Br4923 -----------------------------MGVLTSLIAGLPDGMVVTDSA
:
Rv3107c|M.tuberculosis_H37Rv PDLTALGLAAPRVSPPASLAALCSSDLVDRAG-----HARGKAYRDIARN
Mb3134c|M.bovis_AF2122/97 PDLTALGLAAPRVSPPASLAALCSSDLVDRAG-----HARGKAYRDIARN
MMAR_1525|M.marinum_M PDPAALALPAARVSPPESLAGICSSDPIDRAG-----HARGKAFRDVTRN
Mflv_2772|M.gilvum_PYR-GCK -DQVRLRPSALSPGDRDGLSAIIGAEHVTVDDRARLLRAGGKSTLDLLRR
Mvan_3761|M.vanbaalenii_PYR-1 -EQVRLRPSALSPADLDGLSAVVGAANVTTDDQARLLRAGGKSTLDLLRR
MSMEG_4334|M.smegmatis_MC2_155 -EDITLRPSALTAADRDALAAVVGEQYCRTDDTARLLHAGGKSTLDLLRR
TH_1507|M.thermoresistible__bu -DQVRLRPSALSDADRDALAGVVGADFCRVDEHSRLLHAGGKSTLDLLRR
MAV_2186|M.avium_104 -EQVRLRPSTLSPADREALAAIVGPEYCRTADSDRLLHAGGKSTIDLLSR
MUL_1298|M.ulcerans_Agy99 -DQVKLRPCALSQSDQDALAKIVGPEYMRTADRDRLLRAGGKSTPDMLRR
MAB_3884|M.abscessus_ATCC_1997 -SHVTLTPNSLTDAQRAALGGLLGAEHVSTDHGARLRHSGGKSTPDLLRR
MLBr_01103|M.leprae_Br4923 VTDGYRHDRALDPSAG----------------------------------
: .
Rv3107c|M.tuberculosis_H37Rv LQGQLDHLPDLIARPRSEQDVIDVLDWCAREGIAVIPYGGGSSVVGGVEP
Mb3134c|M.bovis_AF2122/97 LQGQLDHLPDLIARPRSEQDVIDVLDWCAREGIAVIPYGGGSSVVGGVEP
MMAR_1525|M.marinum_M LLGHLDHVPDLIARPRSEQDVVDVLDWCTREQIPAIPYGGGSSVVGGVEP
Mflv_2772|M.gilvum_PYR-GCK RDFGVQDAPDAVLLPGGEDEIAEVLRYCAHRSIAVVPFGGGTSVVGGVDP
Mvan_3761|M.vanbaalenii_PYR-1 RDFGVQDAPDAIVLPGGDRDVAEVLRFCGERSIAVVPFGGGTSVVGGLDP
MSMEG_4334|M.smegmatis_MC2_155 NTSGVQDAPDAILLPGDEDAVAAILRYCTEHRIAIVPFGGGTSVVGGLDP
TH_1507|M.thermoresistible__bu RQP-EQDAPDAVVLPADEDQIAEILRICGSRRIAVVPFGGGTSVVGGLDP
MAV_2186|M.avium_104 NGPGPQDAPDAVLLPGDDESVAAILRYCSQHRIAVVPFGGGTSVVGGLTP
MUL_1298|M.ulcerans_Agy99 KDTGIQDAPDAVLLPGDDQAVAEILRYCSDQGIAIVPFGGGTNVTGALDP
MAB_3884|M.abscessus_ATCC_1997 RSTGVQNAPDAIVYPASHDEVSALLTLCEEQGIAVVPFGGGTSVVGGLDP
MLBr_01103|M.leprae_Br4923 -------KPLAVVQPRRTDEVQTVLRWASANRVPVVARGAGSGLSGGATA
* : * : :* . . :. :. *.*:.: *. .
Rv3107c|M.tuberculosis_H37Rv RFD--EPVVTVDVTAMSAVLEIDRVSRAARIQAGAFGPSIEHQLRPHDLT
Mb3134c|M.bovis_AF2122/97 RFD--EPVVTVDVTAMSAVLEIDRVSRAARIQAGAFGPSIEHQLRPHDLT
MMAR_1525|M.marinum_M RFD--QPAVTVDIGALGAVLEIDRVSRAARIQAGALGPSIEDQLRPHGLT
Mflv_2772|M.gilvum_PYR-GCK LRGDFKAVVSLDLRRLDELHSLDDVSWEAELGAGLTGPEAERLLGERGFS
Mvan_3761|M.vanbaalenii_PYR-1 TRGDFKAVVSLDLRRLDELHSLDEVSWEAELGAGLTGPDAERLLGERGFS
MSMEG_4334|M.smegmatis_MC2_155 LRGEFGAVVSLDLRRLDALHHLDEISGEAELGAGVTGPQAEELLGAHGFS
TH_1507|M.thermoresistible__bu IRGEFGSVVALDLRRLNRLIWLDEVSQLAELSAGMTGPAAEETLRARGFS
MAV_2186|M.avium_104 ERAGFGAAVAVDLRRFDQLISLDPVSGLAVLGAGVTGPDAEKLLGAHGFS
MUL_1298|M.ulcerans_Agy99 NRGQFSAVISLDLRRFNELHSLDEVSGIADLGAGVTGPDAERLLGERGFS
MAB_3884|M.abscessus_ATCC_1997 ERGAFGAVIAIDLRRMSGLLSLDEVSGTAVLLPGTTGPEAEELLGAQGFS
MLBr_01103|M.leprae_Br4923 LDDG----IVLSTEKMRDIT-VDPVTRTAVCQPGLFNAEVKKAAAEHGLW
: :. : : :* :: * .* .. : :.:
Rv3107c|M.tuberculosis_H37Rv LRHFPQSFGFSTLGGWLATRSGGHFATLYTHIDDLTESLRIVTPVGISES
Mb3134c|M.bovis_AF2122/97 LRHFPQSFGFSTLGGWLATRSGGHFATLYTHIDDLTESLRIVTPVGISES
MMAR_1525|M.marinum_M LRHFPQSFGFSSLGGWLATRAGGHFATLYTHIDDLTESMRVVSPAGVGES
Mflv_2772|M.gilvum_PYR-GCK LGHYPQSFLFATIGGFAATRSSGQDSAGYGRFNDMVRGLRAVTPAGVLDL
Mvan_3761|M.vanbaalenii_PYR-1 LGHFPQSFCFATIGGFAATRSSGQDSAGYGRFDDMVRGLRAVTPAGVLDL
MSMEG_4334|M.smegmatis_MC2_155 LGHFPQSFQFATIGGFAATRSSGQNSAGYGRFDDMVRGLRAVTPAGVLDL
TH_1507|M.thermoresistible__bu LGHFPQSFEFASIGGFAATRSSGQNSAGYGRFNDMVRGVRAITPTGVLDL
MAV_2186|M.avium_104 LGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMVRGLRVITPVGTMDL
MUL_1298|M.ulcerans_Agy99 LGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMIIGLRMITPAGVLDL
MAB_3884|M.abscessus_ATCC_1997 LGHFPQSFRFASIGGFAATRSSGQASSGYGRFDAMVDAVRIATPRGDLNL
MLBr_01103|M.leprae_Br4923 YPPDPSSFEICSIGGNVATNAGGLCCVKYGVTGDYVLGIQVVLADGTAVR
*.** .::** **.:.* . * . .:: . *
Rv3107c|M.tuberculosis_H37Rv RRLP--GSGAGPSPDRLFLGSEGTLGIITEAWMRLQHRPRWQVTVSVVFD
Mb3134c|M.bovis_AF2122/97 RRLP--GSGAGPSPDRLFLGSEGTLGIITEAWMRLQHRPRWQVTVSVVFD
MMAR_1525|M.marinum_M RRLP--GSGAGPSPDRMFLGSEGTLGIITEAWMRLQDRPRWQLTASVEFD
Mflv_2772|M.gilvum_PYR-GCK GRAP--ESAAGPDLRQLLIGSEGAFGIITRVRVRVHPVPEVTRYEAWSFP
Mvan_3761|M.vanbaalenii_PYR-1 GRAP--ASAAGPDLRQLLLGSEGTFGIITRVRVRVHPVPEATRYEAWSFP
MSMEG_4334|M.smegmatis_MC2_155 GRAP--ASAAGPDLRQLLLGSEGVFGVITRVRVRVHPVPESTRYEAWSFP
TH_1507|M.thermoresistible__bu GRAP--ESAAGPDLRHLLIGSEGVFGVITRVRVRVRPVPEAVRYEAWSFP
MAV_2186|M.avium_104 GRGP--ESAAGPDLRQLLIGSEGTLGVITRVRLRVHRIPQAVRYEAWSFP
MUL_1298|M.ulcerans_Agy99 GRVA--ASAAGPDLRQLAIGSEGVFGVITKVRLRVHPVPETTRYEAWSFP
MAB_3884|M.abscessus_ATCC_1997 GRAP--ASAAGPDLRQLFLGSEGALGIITEVTLRVHRLPEETWYQGWSFP
MLBr_01103|M.leprae_Br4923 LGGPRLKDVAGLSLTKLFVGSEGTLGIITEVTLRLLPTQNTSSIVVATFA
. . ** . :: :****.:*:**.. :*: . *
Rv3107c|M.tuberculosis_H37Rv DWAAAVAATRTIAQAGLYPANCRLLDPAEALLNAGTS--------VGGGL
Mb3134c|M.bovis_AF2122/97 DWAAAVAATRTIAQAGLYPANCRLLDPAEALLNAGTS--------VGGGL
MMAR_1525|M.marinum_M DWAGAVTATRAIAQAGLYPTNCRLLDPAEAFLNTGTA--------VSGGL
Mflv_2772|M.gilvum_PYR-GCK DFATGADALRAVVQTGTGPTVIRLSDEAETGVNLATTENIGEQKITGGCL
Mvan_3761|M.vanbaalenii_PYR-1 DFATGADALRAVAQTGTGPTVIRLSDEAETGVNLATTESIGEQQVTGGCL
MSMEG_4334|M.smegmatis_MC2_155 DFATGADALRAVVQTGTGPTVIRLSDEAETGVNLATTDNIGEQSITGGCL
TH_1507|M.thermoresistible__bu DFATGTAALRAVTQIGTGPTVIRLSDEAETGVNLATTDNIGDQSITGGCL
MAV_2186|M.avium_104 DFETGAAALRAVTQNGTGPTVIRLSDEAETGVNLATTEAIGESRITGGCL
MUL_1298|M.ulcerans_Agy99 DFSTGVAALRAITQTGTGPTVVRLSDEAETGINLATHESIGENQVTGGCL
MAB_3884|M.abscessus_ATCC_1997 SFEAGAQALRTLVQSDAAPTVLRLSDEAESGLNLALAKDIGGKNPAAGVL
MLBr_01103|M.leprae_Br4923 SVQAAVDAVLGVAAR-LRPAMLEFMDS--VAINAVEDTFRMGLDREAAAM
. .. * :. *: .: * :* .. :
Rv3107c|M.tuberculosis_H37Rv LVLAFESADHPIDPWLHRAVAITAEHGGTVTAQRSRGTTSDATEHN---A
Mb3134c|M.bovis_AF2122/97 LVLAFESADHPIDPWLHRAVAITAEHGGTVTAQRSRGTTSDATEHN---A
MMAR_1525|M.marinum_M LVLAFESADHPIDPWLDRAVEIAAGHGGTVTARRGRETRQAAAAQSGSDV
Mflv_2772|M.gilvum_PYR-GCK AITAFEGTEAHVASRHAETRDLLAAKGGTSLGEAP---------------
Mvan_3761|M.vanbaalenii_PYR-1 AITAFEGTEAHVASRHAETRDLLAASGGTSLGEGP---------------
MSMEG_4334|M.smegmatis_MC2_155 AVTVFEGSPEHTASRHAETRALLERLGGTSLGEVP---------------
TH_1507|M.thermoresistible__bu AITVFEGTAAHAESRHAETAAVLAAHGGTSLGEEP---------------
MAV_2186|M.avium_104 CITMFEGTEQHVDSRHAETRALLAAQGGTSLGDGP---------------
MUL_1298|M.ulcerans_Agy99 GLTLFEGTKEHTESRHAETRASLEAHGGKSLGEGP---------------
MAB_3884|M.abscessus_ATCC_1997 AITTVEGTHGHVAARSAEVAAVLSAAGGTALGDEP---------------
MLBr_01103|M.leprae_Br4923 LVAGSDELGHAGTDEAKLIGAVFAENGATQVSSTN---------------
: : *.. .
Rv3107c|M.tuberculosis_H37Rv AANWRSAFLRMPYQRDALVRRGVIAETFETACTWDGFDTLHAAVTDA--A
Mb3134c|M.bovis_AF2122/97 AANWRSAFLRMPYQRDALVRRGVIAETFETACTWDGFDTLHAAVTDA--A
MMAR_1525|M.marinum_M SQAWRSAFLRMPYQRDALARRSVIAETFETACTWDGFDALHAAVTDA--A
Mflv_2772|M.gilvum_PYR-GCK AKAWEHGRFNAPYLRDALLSAGALCETLETATNWSNVAALKAAVTEA--L
Mvan_3761|M.vanbaalenii_PYR-1 ARAWEHGRFNAPYLRDALLSAGALCETLETATNWSNVAALKAAVTEA--L
MSMEG_4334|M.smegmatis_MC2_155 ARAWEHGRFGAPYLRDSLLAAGALCETLETATNWSNVAALKTAVTEA--L
TH_1507|M.thermoresistible__bu ARAWEHGRFSAPYLRDSLLSAGALCETLETATTWSNIPTLKAAVTDA--L
MAV_2186|M.avium_104 ARAWERGRFGAPYLRDSLLAAGALCETLETATDWSNISALKAAVTQA--L
MUL_1298|M.ulcerans_Agy99 AQGWEHGRFSAPYLRDSLLAASALCETLETATDWSNIAAVKAAVTEA--L
MAB_3884|M.abscessus_ATCC_1997 AKAWDHGRFDAPYLRDALIDAGAVVETLETATSWQNLANLRTAVTTA--L
MLBr_01103|M.leprae_Br4923 ----------DPDEGEAFVAARRFCIPAVESKGSLLLEDVGVPLPALGKL
* ::: . . : . : ..:.
Rv3107c|M.tuberculosis_H37Rv RTAIWKVCGTGVVTCRFTHVYPDGPAPYYGIYAGGRWGSLDAQWDEIKAA
Mb3134c|M.bovis_AF2122/97 RTAIWKVCGTGVVTCRFTHVYPDGPAPYYGIYAGGRWGSLDAQWDEIKAA
MMAR_1525|M.marinum_M RAAIERVCGVGLVTCRFTHVYPDGPAPYYGVYAAGRWGSLDAQWDEIKAA
Mflv_2772|M.gilvum_PYR-GCK TRSLEDSGTPALVLCHISHVYPTGASLYFTVVAA-QRGNPIEQWRKAKAA
Mvan_3761|M.vanbaalenii_PYR-1 TGSLAESGTPALVLCHISHVYPTGASLYFTVVAA-QRGNPIEQWRNAKAA
MSMEG_4334|M.smegmatis_MC2_155 TATLAESGTQALVLCHISHVYPTGASLYFTVVAA-QRGDAAEQWRKAKTA
TH_1507|M.thermoresistible__bu TSTLGESGTSALVMCHISHVYPTGASLYFTVVAA-QRGNPIEQWRTAKAA
MAV_2186|M.avium_104 TTALAQTGTPALVMCHISHVYPTGASLYFTVVAG-QRGDPIEQWKTAKKA
MUL_1298|M.ulcerans_Agy99 TTSLAESGTPALVMCHVSHVYPTGASLYFTVVAG-QRGNPIEQWMAAKKA
MAB_3884|M.abscessus_ATCC_1997 AETLGAQGTPPLVLCHISHTYRTGASLYFTVVCA-AAEDALTQWGRAKQA
MLBr_01103|M.leprae_Br4923 VTGIAHISTERNLMISVIAHAGDGNTHPLIVYNP-ADATMTERAHRAFGE
: : . * : : :
Rv3107c|M.tuberculosis_H37Rv VSEAISASGGTITHHHAVGRDHRAWYDRQRPDPFAAALRAAKSALDPAGI
Mb3134c|M.bovis_AF2122/97 VSEAISASGGTITHHHAVGRDHRAWYDRQRPDPFAAALRAAKSALDPAGI
MMAR_1525|M.marinum_M VSEAISTTGGTITHHHAVGRDHRPWYDRQRPDPFMAALRAAKTALDPAGI
Mflv_2772|M.gilvum_PYR-GCK ASDAMVRTGATITHHHAVGADHRPWMTDEVGGLGVSVLRAVKSVLDPAGI
Mvan_3761|M.vanbaalenii_PYR-1 ASEAMLRSGATITHHHAVGADHRPWMRDEIGDLGVTVLRAVKEALDPAGI
MSMEG_4334|M.smegmatis_MC2_155 ASEAMVRNGATITHHHAVGADHRPWMTEEVGDLGVAVLRAVKATLDPAGI
TH_1507|M.thermoresistible__bu ASDAMMRHGGTITHHHAVGADHRPWMRDEVGGLGVDILRAVKATLDPAGI
MAV_2186|M.avium_104 ASDAIMATGGTITHHHAVGTDHRPWMPEEIGELGVQVLRAVKDTLDPAGI
MUL_1298|M.ulcerans_Agy99 ASDAMMATGATITHHHAVGADHRPWMRDEVGDLGVQLLRAVKATLDPAGI
MAB_3884|M.abscessus_ATCC_1997 AGDAIVAAGGTITHHHAVGRDHQPWLADEVGELGIEILQAVKRTVDPRGI
MLBr_01103|M.leprae_Br4923 IMDMAVGLGGTITGEHGVGRLKRPWLDDYLGPDVMELNQRIKHALDPYGI
: *.*** .*.** ::.* : * .:** **
Rv3107c|M.tuberculosis_H37Rv LNPGVLLGR--
Mb3134c|M.bovis_AF2122/97 LNPGVLLGR--
MMAR_1525|M.marinum_M LNPGVLLDR--
Mflv_2772|M.gilvum_PYR-GCK LNPGKLIP---
Mvan_3761|M.vanbaalenii_PYR-1 LNPGKLIP---
MSMEG_4334|M.smegmatis_MC2_155 LNPGKLIP---
TH_1507|M.thermoresistible__bu LNPGKLIP---
MAV_2186|M.avium_104 LNPGKLIP---
MUL_1298|M.ulcerans_Agy99 LNPGKLIP---
MAB_3884|M.abscessus_ATCC_1997 LNPGKLIPVQG
MLBr_01103|M.leprae_Br4923 LNPGAAI----
**** :