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VLLHDVAITSMDVAATSSRLTKVARIAALLHRAAPDTQLVTIIVSWLSGELPQRHIGVGWAALRSLPPPA PQPALTVTGVDATLSKIGTLPGKGSQAQRAALVAELFSAATEAEQTFLLRLLGGELRQGAKGGIMADAVA QAAGLPAATVQRAAMLGGDLAAAAAAGLSGAALDTFTLRVGRPIGPMLAQTATSVHDALERHGGTTIFEA KLDGARVQIHRANDQVRIYTRSLDDVTARLPEVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRF GRSVDVAAARATQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPTDAANFLDAT LAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGGFVM VGKTFKGMTDAMLDWQTTRFHEIAVGPTDGYVVQLRPEQVVEVALDGVQRSSRYPGGLALRFARVVRYRA DKDPAEADTIDAVRALY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3062 | ligB | - | 100% (507) | ATP-dependent DNA ligase |
| M. tuberculosis H37Rv | Rv0938 | - | 5e-17 | 30.84% (227) | ATP-dependent DNA ligase |
| M. tuberculosis H37Rv | Rv3731 | ligC | 1e-12 | 28.14% (366) | ATP-dependent DNA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3089 | ligB | 0.0 | 99.80% (507) | ATP-dependent DNA ligase |
| M. gilvum PYR-GCK | Mflv_4321 | ligB | 0.0 | 70.59% (510) | ATP-dependent DNA ligase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1033 | - | 2e-13 | 26.85% (324) | ATP-dependent DNA ligase |
| M. marinum M | MMAR_1623 | ligB | 0.0 | 79.44% (501) | ATP-dependent DNA ligase LigB |
| M. avium 104 | MAV_3937 | ligB | 0.0 | 79.65% (516) | ATP-dependent DNA ligase |
| M. smegmatis MC2 155 | MSMEG_2277 | ligB | 0.0 | 71.76% (510) | ATP-dependent DNA ligase |
| M. thermoresistible (build 8) | TH_1632 | ligB | 0.0 | 70.33% (509) | PROBABLE ATP-DEPENDENT DNA LIGASE LIGB |
| M. ulcerans Agy99 | MUL_3413 | ligB | 0.0 | 77.97% (513) | ATP-dependent DNA ligase |
| M. vanbaalenii PYR-1 | Mvan_2025 | ligB | 0.0 | 69.30% (531) | ATP-dependent DNA ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3062|M.tuberculosis_H37Rv --------------------------------------------------
Mb3089|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1623|M.marinum_M --------------------------------------------------
MUL_3413|M.ulcerans_Agy99 --------------------------------------------------
MAV_3937|M.avium_104 --------------------------------------------------
MSMEG_2277|M.smegmatis_MC2_155 --------------------------------------------------
TH_1632|M.thermoresistible__bu --------------------------------------------------
Mflv_4321|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2025|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1033|M.abscessus_ATCC_1997 MLYPATDTSPATTKADVFGYYTAIAPFMLPHIAGRPVTRKRWPNGIDQPS
Rv3062|M.tuberculosis_H37Rv --------------------------------------------------
Mb3089|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1623|M.marinum_M --------------------------------------------------
MUL_3413|M.ulcerans_Agy99 --------------------------------------------------
MAV_3937|M.avium_104 --------------------------------------------------
MSMEG_2277|M.smegmatis_MC2_155 --------------------------------------------------
TH_1632|M.thermoresistible__bu --------------------------------------------------
Mflv_4321|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2025|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1033|M.abscessus_ATCC_1997 FFEKDLASSAPDWLPRRRIEHKSRYVSYPLIDTSVALAWIAQQAALEVHV
Rv3062|M.tuberculosis_H37Rv ---------------------------------------MLLHDVAITSM
Mb3089|M.bovis_AF2122/97 ---------------------------------------MLLHDVAITSM
MMAR_1623|M.marinum_M --------------------------------------------------
MUL_3413|M.ulcerans_Agy99 ---------------------------------------MLLIDIASTSL
MAV_3937|M.avium_104 -----------------------------MSPSHAKLATVLLFDVATASA
MSMEG_2277|M.smegmatis_MC2_155 ----------------------------------------MLADVAAAST
TH_1632|M.thermoresistible__bu -------------------------MSARAGRRPCQADQMLLVDVATASA
Mflv_4321|M.gilvum_PYR-GCK ---------------------------------------MLLVDVAGASA
Mvan_2025|M.vanbaalenii_PYR-1 ---------------------------------------MLLVDVANASA
MAB_1033|M.abscessus_ATCC_1997 PQWRFAGENPGPATRLVFDLDPGEGVGMAQLAEVARAIRDVLADIGLTTF
Rv3062|M.tuberculosis_H37Rv DVAATSSRLTKVARIAALLHRAAPDTQ--LVTIIVSWLSGELP----QRH
Mb3089|M.bovis_AF2122/97 DVAATSSRLTKVARIAALLHRAAPDTQ--LVTIIVSWLSGELP----QRH
MMAR_1623|M.marinum_M -MGGTSSRLAKVERIAELLRAAAPDPE--LVAIVVAWLSGELR----QRQ
MUL_3413|M.ulcerans_Agy99 NVGGTSSRLAKVARIAEPLRAAAPDPE--LVAIVVAWLSGELR----QRQ
MAV_3937|M.avium_104 DVGGTPSRLTKVARIADLLRRAAPDAA--LVAIVVSWLSGELR----QRQ
MSMEG_2277|M.smegmatis_MC2_155 EVAASSARLVKIERIATLLARSAAEDDTQAVAVIVSWLSGELP----QRQ
TH_1632|M.thermoresistible__bu EVGATTARSAKISRIAELLR----DTDAALVPVVVSWLSGELP----QRP
Mflv_4321|M.gilvum_PYR-GCK DVAASSARLAKIARIAELLRRAGRED----VAIVVSWLSGELT----QRQ
Mvan_2025|M.vanbaalenii_PYR-1 DVAAMSARLAKVARIAELLRTAGRQGDARLVRVVVSWLSGELT----QRQ
MAB_1033|M.abscessus_ATCC_1997 PVTSGSKGLHLYVPLAQPASSSGAVAVAKKVAVQLEQVMPDLVTATMTRQ
: . . :* * : : : :* *
Rv3062|M.tuberculosis_H37Rv IGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLPGKGSQAQRAALVAE
Mb3089|M.bovis_AF2122/97 IGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLSGKGSQAQRAALVAE
MMAR_1623|M.marinum_M IGVGWAALRSLPAAAGSPALTVTGTDAAFSEIGAVSGKGSAARRRELITR
MUL_3413|M.ulcerans_Agy99 IGVGWATLRSPPAAAGSPALTVTGTDAAFSEIGAVSGKGSAARRRELITR
MAV_3937|M.avium_104 IGVGWAALRSRPPAAAHPTLTVVAVDAAFAEIGAVAGKGAQARRAALLNA
MSMEG_2277|M.smegmatis_MC2_155 IGVGWAALRTLPPPAATPSLTVDDVDDRLSTIKAVAGKGSQATRAGLVHE
TH_1632|M.thermoresistible__bu IGVGWAALRSLPPPAAAPTLTVAAVDAAFTQIRTVTGKGSQARRAALLAE
Mflv_4321|M.gilvum_PYR-GCK IGVGWASLRSVPAAAAEPTLTVAEVERRFGEIGATAGRGSQARRAQLLAD
Mvan_2025|M.vanbaalenii_PYR-1 IGVGWRSVRSVPDPAAQPSLTVEDVDARFGEIGSTSGKGSQARRAALLAE
MAB_1033|M.abscessus_ATCC_1997 LRAGKVFVDWSQNSGSKTTVAPYSLRGRAVPTVAAPRTWEELDDPGLRQL
: .* : .. .::: : . *
Rv3062|M.tuberculosis_H37Rv LFSAATEAEQT---FLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQR
Mb3089|M.bovis_AF2122/97 LFSAATEAEQT---FLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQR
MMAR_1623|M.marinum_M LFAAATETEQA---FLVRLLSGELRQGALAGIMVDAVARAAEVPATAVQR
MUL_3413|M.ulcerans_Agy99 LFAASTETEQA---FLVRLLSGELRQGALAGIMVDAVARAAEVPATAVQR
MAV_3937|M.avium_104 LFAAATETEQT---FLLRLLGGELRQGALAGIMADAVARAAGIPAAAVQR
MSMEG_2277|M.smegmatis_MC2_155 LFSAATDPEQK---FLRHLLSGELRQGALAGVMADAVAKAAGLPAAEIRR
TH_1632|M.thermoresistible__bu LFGAATGIEQR---FLRGLLSGELRQGALVGVMADAVARAADVPAAAVRR
Mflv_4321|M.gilvum_PYR-GCK LFSAATDVEQT---FLRRLLTGELRQGALVGVMADAVAKAADLPAATVRR
Mvan_2025|M.vanbaalenii_PYR-1 LFAAATAVEQV---FLRRLLTGELRQGALGGVMADAVGKAAGVPSAVVRR
MAB_1033|M.abscessus_ATCC_1997 RYDEVLTRAQRDGDLLAGLDDVEIAEDRLSTYRSMRDPTRTPEPVPAVKP
: * :* * *: :. : * . ::
Rv3062|M.tuberculosis_H37Rv AAMLGGDLAAAAAAGL---------SGAALDTFTLRVGRPIGPMLAQTAT
Mb3089|M.bovis_AF2122/97 AAMLGGDLAAAAAAGL---------SGAALDTFTLRVGRPIGPMLAQTAT
MMAR_1623|M.marinum_M AAMLGGDLPTVAAACL---AAGSSGAAGALDSFTLRVGRPIGPMLAQSAG
MUL_3413|M.ulcerans_Agy99 AAMLGGDLPTVAAACL---AAGSSGAAGALDSFTLRVGRPIGPMLAQSAG
MAV_3937|M.avium_104 AAMLGGDLPAVAAAALSGEAAALSGEASALDAFTLRVGRPVAPMLAQTAA
MSMEG_2277|M.smegmatis_MC2_155 AAMLAGNLPAVAAAAVT-------GGRAALADFRLRVGRPVGPMLAQTAT
TH_1632|M.thermoresistible__bu AAMLAGELPTVAGAALT-------GGTDALSRYTLRVGQPVGPMLAQTAA
Mflv_4321|M.gilvum_PYR-GCK AAMLGGDLPAVAAAALT-------DGDAGLAQFTLQAGKAVGPMLAQTAA
Mvan_2025|M.vanbaalenii_PYR-1 AAMLGGDLPAVAAAAVT-------DGESALAQFTLQVGRPVGPMLAQTAT
MAB_1033|M.abscessus_ATCC_1997 EAGQDNSFVIQEHHATALHYDFRLERDGVLVSWAVPKNLPLEPSVNHLAV
* ..: * : : . .: * : : *
Rv3062|M.tuberculosis_H37Rv SVHDALERHG----------------------------------------
Mb3089|M.bovis_AF2122/97 SVHDALERHG----------------------------------------
MMAR_1623|M.marinum_M SITVALERHG----------------------------------------
MUL_3413|M.ulcerans_Agy99 SITDALERHG----------------------------------------
MAV_3937|M.avium_104 GVAEAIERHG----------------------------------------
MSMEG_2277|M.smegmatis_MC2_155 SVDDALQRLG----------------------------------------
TH_1632|M.thermoresistible__bu GVTEALERLG----------------------------------------
Mflv_4321|M.gilvum_PYR-GCK DVTDALDRLG----------------------------------------
Mvan_2025|M.vanbaalenii_PYR-1 GVADALDRFG----------------------------------------
MAB_1033|M.abscessus_ATCC_1997 HTEDHPLEYGSFEGTIPKGEYGAGEVTIWDSGTYDTEKFIDPRDDSGADG
. *
Rv3062|M.tuberculosis_H37Rv --------------------------------------------------
Mb3089|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1623|M.marinum_M --------------------------------------------------
MUL_3413|M.ulcerans_Agy99 --------------------------------------------------
MAV_3937|M.avium_104 --------------------------------------------------
MSMEG_2277|M.smegmatis_MC2_155 --------------------------------------------------
TH_1632|M.thermoresistible__bu --------------------------------------------------
Mflv_4321|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2025|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1033|M.abscessus_ATCC_1997 GQKGEVIVTLHGKRITGRYALIRTNGKQWLVHRMKDQRPAGSMPVGLAPM
Rv3062|M.tuberculosis_H37Rv ------------GTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLP
Mb3089|M.bovis_AF2122/97 ------------GTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLP
MMAR_1623|M.marinum_M ------------GATIFEAKLDGARVQIHRTGDEVTVYTRSLDDVTARLP
MUL_3413|M.ulcerans_Agy99 ------------GATIFEAKLDGARVQIHRTGDEVTVYTRSLDDVTARLP
MAV_3937|M.avium_104 ------------GQAIFEAKLDGARVQIHRAGDQVTVYTRSLDDVTARLP
MSMEG_2277|M.smegmatis_MC2_155 ------------GTAVLEAKLDGARVQIHRSGCDVSIYTRSLDDVTHRLP
TH_1632|M.thermoresistible__bu ------------GTAVLEAKLDGARVQIHRSRREVAIFTRSLDDVTARLP
Mflv_4321|M.gilvum_PYR-GCK ------------GTAMFEAKLDGARVQIHRRGDSVSIFTRSLDDVTARLP
Mvan_2025|M.vanbaalenii_PYR-1 ------------GTALFEAKLDGARVQIHRRGDAVSVFTRSLDDVTARLP
MAB_1033|M.abscessus_ATCC_1997 LPTTGSVAGLTAEEWAFEGKWDGYRLILECDRGQLRALARSGRDVTAEFP
:*.* ** *: :. : :** *** .:*
Rv3062|M.tuberculosis_H37Rv EVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARA
Mb3089|M.bovis_AF2122/97 EVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARA
MMAR_1623|M.marinum_M EVVQATLALPVSDLVADGEAIALQPDGRPHRFQVTASRFGRSVNVAAAQA
MUL_3413|M.ulcerans_Agy99 EVVQATLALPVSDLVADGEAIALQPDGRPHRFQVTASRFGRSVNVAAAQA
MAV_3937|M.avium_104 EVVTATLALPVEALIADGEAIALRPDNSPQRFQVTASRFGRSVDVAAAVA
MSMEG_2277|M.smegmatis_MC2_155 EVVEATLALPATELIADAEAIALRPDGRPHLFQVTAARFGRKD----PGD
TH_1632|M.thermoresistible__bu EVVEAALTWPVSEVIADAEAIALRPDGRPHRFQVTASRFGRAG----PGA
Mflv_4321|M.gilvum_PYR-GCK EVVEATLALPVTDLIADAEAIALRPDGRPHRFQVTASRFGRRGGTS-DTA
Mvan_2025|M.vanbaalenii_PYR-1 EVVDATLALPVTELIADAEAIALRPDGRPHRFQITASRFGRRGGTP-DAG
MAB_1033|M.abscessus_ATCC_1997 ALQRLAHELSDHRVVLDGEVVVPDRKGLPS-FALLQNRT----------P
: : . :: *.*.:. .. * * : *
Rv3062|M.tuberculosis_H37Rv TQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPT
Mb3089|M.bovis_AF2122/97 TQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPT
MMAR_1623|M.marinum_M KQPLSVFFFDILHRDGRDLLDAPTTDRLAALDAVVPARHRVDRLTTADAA
MUL_3413|M.ulcerans_Agy99 KQPLSVFFSDILHRDGRDLLDAPTTDRLAALDAVVPARHRVDRLTTADAA
MAV_3937|M.avium_104 AQPLSVFFFDILHCDGVDLLDAPTTDRLAALDALVPPAQRVDQLLTADPD
MSMEG_2277|M.smegmatis_MC2_155 LGPLSVFFFDLLHVDGRDLLDLPTEERFGALDALVRQDQRVDRLVTTDTV
TH_1632|M.thermoresistible__bu APPLSVFVFDLLHVDGDDLLDRPTGARLEVLDALIPDRHRVDRLVTADPA
Mflv_4321|M.gilvum_PYR-GCK SNPLSVFFFDLLHVDGVDLLDAPAHERIARLDAVTPDSQRVDRLVTSDPG
Mvan_2025|M.vanbaalenii_PYR-1 TQRLSVFFFDLLHADGVDLLDLPTGERIATLDATVPREQRVDRLLTSDPE
MAB_1033|M.abscessus_ATCC_1997 GADIRFWAFDLLYLDGKSLLRTKYRDRRRLLEVLVTGTESMTVPQQLS-G
: .: *:*: ** .** * *:. . : .
Rv3062|M.tuberculosis_H37Rv DAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLA
Mb3089|M.bovis_AF2122/97 DAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLA
MMAR_1623|M.marinum_M AATDFLRATLAAGHEGVMAKSPTAPYLAGRRGAGWLKVKPVHTLDLVVLA
MUL_3413|M.ulcerans_Agy99 AATDFLRATLAAGHEGVMAKSPTAPYLAGRRGAGWLKVKPVHTLDLVVLA
MAV_3937|M.avium_104 AAGRFLEATLAAGHEGVMAKAPGAPYQAGRRGAGWLKVKPVHTLDLVVLA
MSMEG_2277|M.smegmatis_MC2_155 AAQEFLERTLAAGHEGVMAKSPHAAYEAGRRGAGWLKVKPVHTLDLVVLA
TH_1632|M.thermoresistible__bu AAERFLRATLDAGHEGVMAKSPSAAYEAGRRGAGWLKVKPVHTLDVVVLA
Mflv_4321|M.gilvum_PYR-GCK AAQEFFDRTLAAGHEGVMAKSTVAPYEAGRRGAGWLKVKPVHTLDLVVLA
Mvan_2025|M.vanbaalenii_PYR-1 AAQAFLDATLAAGHEGVMAKSPTAPYEAGRRGAGWLKVKPVHTLDLVVLA
MAB_1033|M.abscessus_ATCC_1997 DGAAALAYSQDQGWEGVVAKRLDSTYVPGRTQS-WIKAKNWSSQEVVIGG
. : : * ***:** : * .** : *:*.* : ::*: .
Rv3062|M.tuberculosis_H37Rv VEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFH
Mb3089|M.bovis_AF2122/97 VEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFH
MMAR_1623|M.marinum_M VEWGSGRRRGKLSNIHLGARDAATGEFVMLGKTFKGMTDAMLDWQTARFT
MUL_3413|M.ulcerans_Agy99 VEWGSGRRRGKLSNIPLGARDAATGEFVMLGKTFKSMTDAMLDWQTARFT
MAV_3937|M.avium_104 VEWGSGRRRGKLSNIHLGARDPATGEFVMVGKTFKGMTDAMLDWQTARFT
MSMEG_2277|M.smegmatis_MC2_155 VEWGSGRRQGKLSNIHLGARDPDSSGFVMLGKTFKGMTDAMLEWQTQRFL
TH_1632|M.thermoresistible__bu VEWGSGRRAGKLSNIHLGARDPRTGGFVMLGKTFKGMTDAMLEWQTARFL
Mflv_4321|M.gilvum_PYR-GCK VEWGSGRRSGKLSNIHLGARDPGTGGFVMLGKTFKGMTDEMLAWQTRRFL
Mvan_2025|M.vanbaalenii_PYR-1 VEWGSGRRTGKLSNIHLGARDPATGGFVMLGKTFKGMTDEMLAWQTERFL
MAB_1033|M.abscessus_ATCC_1997 WRKGQGGRSSGIGSLLMG--IPVEGGLRYAGRVGTGFTERELSSLKERLE
. *.* * . :..: :* . . : *:. ..:*: * . *:
Rv3062|M.tuberculosis_H37Rv EIAVG--------------------PTDGYVVQLRPEQVVEVALDGVQRS
Mb3089|M.bovis_AF2122/97 EIAVG--------------------PTDGYVVQLRPEQVVEVALDGVQRS
MMAR_1623|M.marinum_M ELAVG--------------------GTDGYVVALRPEQVVEVAFDGVQAS
MUL_3413|M.ulcerans_Agy99 ELAVG--------------------GTDGYVVALRPEQVVEVAFDGVQAS
MAV_3937|M.avium_104 ELAVG--------------------GTDGYVVRVRPEQVVEVAVDGVQKS
MSMEG_2277|M.smegmatis_MC2_155 ELADG--------------------PTDGYVVHLRPEQVVEIAFDGVQRS
TH_1632|M.thermoresistible__bu ELADG--------------------PTTGHVVRLRPEQVVEIAFDGVQRS
Mflv_4321|M.gilvum_PYR-GCK DLADG-------------------DATDHYVVKVRPEQVVEIAFDGLQTS
Mvan_2025|M.vanbaalenii_PYR-1 ELADGAAPAATADHGAAPAATADHGAADGFTVTVRPEQVVEIAFDGIQTS
MAB_1033|M.abscessus_ATCC_1997 PLHRAESP----------------FDAPLSTVEAKDVQFVEPVLVAEVRY
: . : .* : *.** .. .
Rv3062|M.tuberculosis_H37Rv SRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY----
Mb3089|M.bovis_AF2122/97 SRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY----
MMAR_1623|M.marinum_M SRYPGGLALRFARVVRYRDDKGPADADTIDTVRALY----
MUL_3413|M.ulcerans_Agy99 SRYPGGLALRFARVVRYRDDKGPADADTIDTVRALY----
MAV_3937|M.avium_104 SRYPGGLALRFARVLRYRDDKGPAEADTIDAVRALY----
MSMEG_2277|M.smegmatis_MC2_155 SRYPAGMALRFVRVLRYRDDKSPAEADTVETVRRFYERD-
TH_1632|M.thermoresistible__bu SRYPGGMALRFARVLRYRDDKTPDEADTVDTVRRIYERGD
Mflv_4321|M.gilvum_PYR-GCK TRYPGGMALRFARVVRYRDDKAATDADTIDTVREIYERGN
Mvan_2025|M.vanbaalenii_PYR-1 SRYPGGMALRFARVLCYRDDKTAAEADTIDTVRALHERAN
MAB_1033|M.abscessus_ATCC_1997 GDRTPGGILKHSSWRGLRTDKSVRDVELDLG---------
. * *:. * ** :.: