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LSPSHAKLATVLLFDVATASADVGGTPSRLTKVARIADLLRRAAPDAALVAIVVSWLSGELRQRQIGVGW AALRSRPPAAAHPTLTVVAVDAAFAEIGAVAGKGAQARRAALLNALFAAATETEQTFLLRLLGGELRQGA LAGIMADAVARAAGIPAAAVQRAAMLGGDLPAVAAAALSGEAAALSGEASALDAFTLRVGRPVAPMLAQT AAGVAEAIERHGGQAIFEAKLDGARVQIHRAGDQVTVYTRSLDDVTARLPEVVTATLALPVEALIADGEA IALRPDNSPQRFQVTASRFGRSVDVAAAVAAQPLSVFFFDILHCDGVDLLDAPTTDRLAALDALVPPAQR VDQLLTADPDAAGRFLEATLAAGHEGVMAKAPGAPYQAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRG KLSNIHLGARDPATGEFVMVGKTFKGMTDAMLDWQTARFTELAVGGTDGYVVRVRPEQVVEVAVDGVQKS SRYPGGLALRFARVLRYRDDKGPAEADTIDAVRALY
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_3937 | ligB | - | 100% (526) | ATP-dependent DNA ligase |
M. avium 104 | MAV_1056 | - | 6e-17 | 30.65% (248) | ATP-dependent DNA ligase |
M. avium 104 | MAV_3148 | ligD | 3e-15 | 28.66% (307) | DNA polymerase LigD ligase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3089 | ligB | 0.0 | 79.65% (516) | ATP-dependent DNA ligase |
M. gilvum PYR-GCK | Mflv_4321 | ligB | 0.0 | 71.76% (517) | ATP-dependent DNA ligase |
M. tuberculosis H37Rv | Rv3062 | ligB | 0.0 | 79.65% (516) | ATP-dependent DNA ligase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_1033 | - | 5e-13 | 27.33% (322) | ATP-dependent DNA ligase |
M. marinum M | MMAR_1623 | ligB | 0.0 | 81.94% (504) | ATP-dependent DNA ligase LigB |
M. smegmatis MC2 155 | MSMEG_2277 | ligB | 0.0 | 69.44% (517) | ATP-dependent DNA ligase |
M. thermoresistible (build 8) | TH_1632 | ligB | 0.0 | 73.06% (516) | PROBABLE ATP-DEPENDENT DNA LIGASE LIGB |
M. ulcerans Agy99 | MUL_3413 | ligB | 0.0 | 80.23% (516) | ATP-dependent DNA ligase |
M. vanbaalenii PYR-1 | Mvan_2025 | ligB | 0.0 | 71.38% (538) | ATP-dependent DNA ligase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_1623|M.marinum_M -------------------------------------------------- MUL_3413|M.ulcerans_Agy99 -------------------------------------------------- MAV_3937|M.avium_104 -------------------------------------------------- Mb3089|M.bovis_AF2122/97 -------------------------------------------------- Rv3062|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_2277|M.smegmatis_MC2_155 -------------------------------------------------- TH_1632|M.thermoresistible__bu -------------------------------------------------- Mflv_4321|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2025|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1033|M.abscessus_ATCC_1997 MLYPATDTSPATTKADVFGYYTAIAPFMLPHIAGRPVTRKRWPNGIDQPS MMAR_1623|M.marinum_M -------------------------------------------------- MUL_3413|M.ulcerans_Agy99 -------------------------------------------------- MAV_3937|M.avium_104 -------------------------------------------------- Mb3089|M.bovis_AF2122/97 -------------------------------------------------- Rv3062|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_2277|M.smegmatis_MC2_155 -------------------------------------------------- TH_1632|M.thermoresistible__bu -------------------------------------------------- Mflv_4321|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2025|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1033|M.abscessus_ATCC_1997 FFEKDLASSAPDWLPRRRIEHKSRYVSYPLIDTSVALAWIAQQAALEVHV MMAR_1623|M.marinum_M -------------------------------------------------- MUL_3413|M.ulcerans_Agy99 ---------------------------------------MLLIDIASTSL MAV_3937|M.avium_104 -----------------------------MSPSHAKLATVLLFDVATASA Mb3089|M.bovis_AF2122/97 ---------------------------------------MLLHDVAITSM Rv3062|M.tuberculosis_H37Rv ---------------------------------------MLLHDVAITSM MSMEG_2277|M.smegmatis_MC2_155 ----------------------------------------MLADVAAAST TH_1632|M.thermoresistible__bu -------------------------MSARAGRRPCQADQMLLVDVATASA Mflv_4321|M.gilvum_PYR-GCK ---------------------------------------MLLVDVAGASA Mvan_2025|M.vanbaalenii_PYR-1 ---------------------------------------MLLVDVANASA MAB_1033|M.abscessus_ATCC_1997 PQWRFAGENPGPATRLVFDLDPGEGVGMAQLAEVARAIRDVLADIGLTTF MMAR_1623|M.marinum_M -MGGTSSRLAKVERIAELLRAAAPDPE--LVAIVVAWLSGELR----QRQ MUL_3413|M.ulcerans_Agy99 NVGGTSSRLAKVARIAEPLRAAAPDPE--LVAIVVAWLSGELR----QRQ MAV_3937|M.avium_104 DVGGTPSRLTKVARIADLLRRAAPDAA--LVAIVVSWLSGELR----QRQ Mb3089|M.bovis_AF2122/97 DVAATSSRLTKVARIAALLHRAAPDTQ--LVTIIVSWLSGELP----QRH Rv3062|M.tuberculosis_H37Rv DVAATSSRLTKVARIAALLHRAAPDTQ--LVTIIVSWLSGELP----QRH MSMEG_2277|M.smegmatis_MC2_155 EVAASSARLVKIERIATLLARSAAEDDTQAVAVIVSWLSGELP----QRQ TH_1632|M.thermoresistible__bu EVGATTARSAKISRIAELLR----DTDAALVPVVVSWLSGELP----QRP Mflv_4321|M.gilvum_PYR-GCK DVAASSARLAKIARIAELLRRAGRED----VAIVVSWLSGELT----QRQ Mvan_2025|M.vanbaalenii_PYR-1 DVAAMSARLAKVARIAELLRTAGRQGDARLVRVVVSWLSGELT----QRQ MAB_1033|M.abscessus_ATCC_1997 PVTSGSKGLHLYVPLAQPASSSGAVAVAKKVAVQLEQVMPDLVTATMTRQ : . . :* * : : : :* * MMAR_1623|M.marinum_M IGVGWAALRSLPAAAGSPALTVTGTDAAFSEIGAVSGKGSAARRRELITR MUL_3413|M.ulcerans_Agy99 IGVGWATLRSPPAAAGSPALTVTGTDAAFSEIGAVSGKGSAARRRELITR MAV_3937|M.avium_104 IGVGWAALRSRPPAAAHPTLTVVAVDAAFAEIGAVAGKGAQARRAALLNA Mb3089|M.bovis_AF2122/97 IGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLSGKGSQAQRAALVAE Rv3062|M.tuberculosis_H37Rv IGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLPGKGSQAQRAALVAE MSMEG_2277|M.smegmatis_MC2_155 IGVGWAALRTLPPPAATPSLTVDDVDDRLSTIKAVAGKGSQATRAGLVHE TH_1632|M.thermoresistible__bu IGVGWAALRSLPPPAAAPTLTVAAVDAAFTQIRTVTGKGSQARRAALLAE Mflv_4321|M.gilvum_PYR-GCK IGVGWASLRSVPAAAAEPTLTVAEVERRFGEIGATAGRGSQARRAQLLAD Mvan_2025|M.vanbaalenii_PYR-1 IGVGWRSVRSVPDPAAQPSLTVEDVDARFGEIGSTSGKGSQARRAALLAE MAB_1033|M.abscessus_ATCC_1997 LRAGKVFVDWSQNSGSKTTVAPYSLRGRAVPTVAAPRTWEELDDPGLRQL : .* : .. .::: : . * MMAR_1623|M.marinum_M LFAAATETEQA---FLVRLLSGELRQGALAGIMVDAVARAAEVPATAVQR MUL_3413|M.ulcerans_Agy99 LFAASTETEQA---FLVRLLSGELRQGALAGIMVDAVARAAEVPATAVQR MAV_3937|M.avium_104 LFAAATETEQT---FLLRLLGGELRQGALAGIMADAVARAAGIPAAAVQR Mb3089|M.bovis_AF2122/97 LFSAATEAEQT---FLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQR Rv3062|M.tuberculosis_H37Rv LFSAATEAEQT---FLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQR MSMEG_2277|M.smegmatis_MC2_155 LFSAATDPEQK---FLRHLLSGELRQGALAGVMADAVAKAAGLPAAEIRR TH_1632|M.thermoresistible__bu LFGAATGIEQR---FLRGLLSGELRQGALVGVMADAVARAADVPAAAVRR Mflv_4321|M.gilvum_PYR-GCK LFSAATDVEQT---FLRRLLTGELRQGALVGVMADAVAKAADLPAATVRR Mvan_2025|M.vanbaalenii_PYR-1 LFAAATAVEQV---FLRRLLTGELRQGALGGVMADAVGKAAGVPSAVVRR MAB_1033|M.abscessus_ATCC_1997 RYDEVLTRAQRDGDLLAGLDDVEIAEDRLSTYRSMRDPTRTPEPVPAVKP : * :* * *: :. : * . :: MMAR_1623|M.marinum_M AAMLGGDLPTVAAACL---AAGSSGAAGALDSFTLRVGRPIGPMLAQSAG MUL_3413|M.ulcerans_Agy99 AAMLGGDLPTVAAACL---AAGSSGAAGALDSFTLRVGRPIGPMLAQSAG MAV_3937|M.avium_104 AAMLGGDLPAVAAAALSGEAAALSGEASALDAFTLRVGRPVAPMLAQTAA Mb3089|M.bovis_AF2122/97 AAMLGGDLAAAAAAGL---------SGAALDTFTLRVGRPIGPMLAQTAT Rv3062|M.tuberculosis_H37Rv AAMLGGDLAAAAAAGL---------SGAALDTFTLRVGRPIGPMLAQTAT MSMEG_2277|M.smegmatis_MC2_155 AAMLAGNLPAVAAAAVT-------GGRAALADFRLRVGRPVGPMLAQTAT TH_1632|M.thermoresistible__bu AAMLAGELPTVAGAALT-------GGTDALSRYTLRVGQPVGPMLAQTAA Mflv_4321|M.gilvum_PYR-GCK AAMLGGDLPAVAAAALT-------DGDAGLAQFTLQAGKAVGPMLAQTAA Mvan_2025|M.vanbaalenii_PYR-1 AAMLGGDLPAVAAAAVT-------DGESALAQFTLQVGRPVGPMLAQTAT MAB_1033|M.abscessus_ATCC_1997 EAGQDNSFVIQEHHATALHYDFRLERDGVLVSWAVPKNLPLEPSVNHLAV * ..: * : : . .: * : : * MMAR_1623|M.marinum_M SITVALERHG---------------------------------------- MUL_3413|M.ulcerans_Agy99 SITDALERHG---------------------------------------- MAV_3937|M.avium_104 GVAEAIERHG---------------------------------------- Mb3089|M.bovis_AF2122/97 SVHDALERHG---------------------------------------- Rv3062|M.tuberculosis_H37Rv SVHDALERHG---------------------------------------- MSMEG_2277|M.smegmatis_MC2_155 SVDDALQRLG---------------------------------------- TH_1632|M.thermoresistible__bu GVTEALERLG---------------------------------------- Mflv_4321|M.gilvum_PYR-GCK DVTDALDRLG---------------------------------------- Mvan_2025|M.vanbaalenii_PYR-1 GVADALDRFG---------------------------------------- MAB_1033|M.abscessus_ATCC_1997 HTEDHPLEYGSFEGTIPKGEYGAGEVTIWDSGTYDTEKFIDPRDDSGADG . * MMAR_1623|M.marinum_M -------------------------------------------------- MUL_3413|M.ulcerans_Agy99 -------------------------------------------------- MAV_3937|M.avium_104 -------------------------------------------------- Mb3089|M.bovis_AF2122/97 -------------------------------------------------- Rv3062|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_2277|M.smegmatis_MC2_155 -------------------------------------------------- TH_1632|M.thermoresistible__bu -------------------------------------------------- Mflv_4321|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2025|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1033|M.abscessus_ATCC_1997 GQKGEVIVTLHGKRITGRYALIRTNGKQWLVHRMKDQRPAGSMPVGLAPM MMAR_1623|M.marinum_M ------------GATIFEAKLDGARVQIHRTGDEVTVYTRSLDDVTARLP MUL_3413|M.ulcerans_Agy99 ------------GATIFEAKLDGARVQIHRTGDEVTVYTRSLDDVTARLP MAV_3937|M.avium_104 ------------GQAIFEAKLDGARVQIHRAGDQVTVYTRSLDDVTARLP Mb3089|M.bovis_AF2122/97 ------------GTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLP Rv3062|M.tuberculosis_H37Rv ------------GTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLP MSMEG_2277|M.smegmatis_MC2_155 ------------GTAVLEAKLDGARVQIHRSGCDVSIYTRSLDDVTHRLP TH_1632|M.thermoresistible__bu ------------GTAVLEAKLDGARVQIHRSRREVAIFTRSLDDVTARLP Mflv_4321|M.gilvum_PYR-GCK ------------GTAMFEAKLDGARVQIHRRGDSVSIFTRSLDDVTARLP Mvan_2025|M.vanbaalenii_PYR-1 ------------GTALFEAKLDGARVQIHRRGDAVSVFTRSLDDVTARLP MAB_1033|M.abscessus_ATCC_1997 LPTTGSVAGLTAEEWAFEGKWDGYRLILECDRGQLRALARSGRDVTAEFP :*.* ** *: :. : :** *** .:* MMAR_1623|M.marinum_M EVVQATLALPVSDLVADGEAIALQPDGRPHRFQVTASRFGRSVNVAAAQA MUL_3413|M.ulcerans_Agy99 EVVQATLALPVSDLVADGEAIALQPDGRPHRFQVTASRFGRSVNVAAAQA MAV_3937|M.avium_104 EVVTATLALPVEALIADGEAIALRPDNSPQRFQVTASRFGRSVDVAAAVA Mb3089|M.bovis_AF2122/97 EVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARA Rv3062|M.tuberculosis_H37Rv EVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARA MSMEG_2277|M.smegmatis_MC2_155 EVVEATLALPATELIADAEAIALRPDGRPHLFQVTAARFGRKD----PGD TH_1632|M.thermoresistible__bu EVVEAALTWPVSEVIADAEAIALRPDGRPHRFQVTASRFGRAG----PGA Mflv_4321|M.gilvum_PYR-GCK EVVEATLALPVTDLIADAEAIALRPDGRPHRFQVTASRFGRRGGTS-DTA Mvan_2025|M.vanbaalenii_PYR-1 EVVDATLALPVTELIADAEAIALRPDGRPHRFQITASRFGRRGGTP-DAG MAB_1033|M.abscessus_ATCC_1997 ALQRLAHELSDHRVVLDGEVVVPDRKGLPS-FALLQNRT----------P : : . :: *.*.:. .. * * : * MMAR_1623|M.marinum_M KQPLSVFFFDILHRDGRDLLDAPTTDRLAALDAVVPARHRVDRLTTADAA MUL_3413|M.ulcerans_Agy99 KQPLSVFFSDILHRDGRDLLDAPTTDRLAALDAVVPARHRVDRLTTADAA MAV_3937|M.avium_104 AQPLSVFFFDILHCDGVDLLDAPTTDRLAALDALVPPAQRVDQLLTADPD Mb3089|M.bovis_AF2122/97 TQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPT Rv3062|M.tuberculosis_H37Rv TQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPT MSMEG_2277|M.smegmatis_MC2_155 LGPLSVFFFDLLHVDGRDLLDLPTEERFGALDALVRQDQRVDRLVTTDTV TH_1632|M.thermoresistible__bu APPLSVFVFDLLHVDGDDLLDRPTGARLEVLDALIPDRHRVDRLVTADPA Mflv_4321|M.gilvum_PYR-GCK SNPLSVFFFDLLHVDGVDLLDAPAHERIARLDAVTPDSQRVDRLVTSDPG Mvan_2025|M.vanbaalenii_PYR-1 TQRLSVFFFDLLHADGVDLLDLPTGERIATLDATVPREQRVDRLLTSDPE MAB_1033|M.abscessus_ATCC_1997 GADIRFWAFDLLYLDGKSLLRTKYRDRRRLLEVLVTGTESMTVPQQLS-G : .: *:*: ** .** * *:. . : . MMAR_1623|M.marinum_M AATDFLRATLAAGHEGVMAKSPTAPYLAGRRGAGWLKVKPVHTLDLVVLA MUL_3413|M.ulcerans_Agy99 AATDFLRATLAAGHEGVMAKSPTAPYLAGRRGAGWLKVKPVHTLDLVVLA MAV_3937|M.avium_104 AAGRFLEATLAAGHEGVMAKAPGAPYQAGRRGAGWLKVKPVHTLDLVVLA Mb3089|M.bovis_AF2122/97 DAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLA Rv3062|M.tuberculosis_H37Rv DAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLA MSMEG_2277|M.smegmatis_MC2_155 AAQEFLERTLAAGHEGVMAKSPHAAYEAGRRGAGWLKVKPVHTLDLVVLA TH_1632|M.thermoresistible__bu AAERFLRATLDAGHEGVMAKSPSAAYEAGRRGAGWLKVKPVHTLDVVVLA Mflv_4321|M.gilvum_PYR-GCK AAQEFFDRTLAAGHEGVMAKSTVAPYEAGRRGAGWLKVKPVHTLDLVVLA Mvan_2025|M.vanbaalenii_PYR-1 AAQAFLDATLAAGHEGVMAKSPTAPYEAGRRGAGWLKVKPVHTLDLVVLA MAB_1033|M.abscessus_ATCC_1997 DGAAALAYSQDQGWEGVVAKRLDSTYVPGRTQS-WIKAKNWSSQEVVIGG . : : * ***:** : * .** : *:*.* : ::*: . MMAR_1623|M.marinum_M VEWGSGRRRGKLSNIHLGARDAATGEFVMLGKTFKGMTDAMLDWQTARFT MUL_3413|M.ulcerans_Agy99 VEWGSGRRRGKLSNIPLGARDAATGEFVMLGKTFKSMTDAMLDWQTARFT MAV_3937|M.avium_104 VEWGSGRRRGKLSNIHLGARDPATGEFVMVGKTFKGMTDAMLDWQTARFT Mb3089|M.bovis_AF2122/97 VEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFH Rv3062|M.tuberculosis_H37Rv VEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFH MSMEG_2277|M.smegmatis_MC2_155 VEWGSGRRQGKLSNIHLGARDPDSSGFVMLGKTFKGMTDAMLEWQTQRFL TH_1632|M.thermoresistible__bu VEWGSGRRAGKLSNIHLGARDPRTGGFVMLGKTFKGMTDAMLEWQTARFL Mflv_4321|M.gilvum_PYR-GCK VEWGSGRRSGKLSNIHLGARDPGTGGFVMLGKTFKGMTDEMLAWQTRRFL Mvan_2025|M.vanbaalenii_PYR-1 VEWGSGRRTGKLSNIHLGARDPATGGFVMLGKTFKGMTDEMLAWQTERFL MAB_1033|M.abscessus_ATCC_1997 WRKGQGGRSSGIGSLLMG--IPVEGGLRYAGRVGTGFTERELSSLKERLE . *.* * . :..: :* . . : *:. ..:*: * . *: MMAR_1623|M.marinum_M ELAVG--------------------GTDGYVVALRPEQVVEVAFDGVQAS MUL_3413|M.ulcerans_Agy99 ELAVG--------------------GTDGYVVALRPEQVVEVAFDGVQAS MAV_3937|M.avium_104 ELAVG--------------------GTDGYVVRVRPEQVVEVAVDGVQKS Mb3089|M.bovis_AF2122/97 EIAVG--------------------PTDGYVVQLRPEQVVEVALDGVQRS Rv3062|M.tuberculosis_H37Rv EIAVG--------------------PTDGYVVQLRPEQVVEVALDGVQRS MSMEG_2277|M.smegmatis_MC2_155 ELADG--------------------PTDGYVVHLRPEQVVEIAFDGVQRS TH_1632|M.thermoresistible__bu ELADG--------------------PTTGHVVRLRPEQVVEIAFDGVQRS Mflv_4321|M.gilvum_PYR-GCK DLADG-------------------DATDHYVVKVRPEQVVEIAFDGLQTS Mvan_2025|M.vanbaalenii_PYR-1 ELADGAAPAATADHGAAPAATADHGAADGFTVTVRPEQVVEIAFDGIQTS MAB_1033|M.abscessus_ATCC_1997 PLHRAESP----------------FDAPLSTVEAKDVQFVEPVLVAEVRY : . : .* : *.** .. . MMAR_1623|M.marinum_M SRYPGGLALRFARVVRYRDDKGPADADTIDTVRALY---- MUL_3413|M.ulcerans_Agy99 SRYPGGLALRFARVVRYRDDKGPADADTIDTVRALY---- MAV_3937|M.avium_104 SRYPGGLALRFARVLRYRDDKGPAEADTIDAVRALY---- Mb3089|M.bovis_AF2122/97 SRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY---- Rv3062|M.tuberculosis_H37Rv SRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY---- MSMEG_2277|M.smegmatis_MC2_155 SRYPAGMALRFVRVLRYRDDKSPAEADTVETVRRFYERD- TH_1632|M.thermoresistible__bu SRYPGGMALRFARVLRYRDDKTPDEADTVDTVRRIYERGD Mflv_4321|M.gilvum_PYR-GCK TRYPGGMALRFARVVRYRDDKAATDADTIDTVREIYERGN Mvan_2025|M.vanbaalenii_PYR-1 SRYPGGMALRFARVLCYRDDKTAAEADTIDTVRALHERAN MAB_1033|M.abscessus_ATCC_1997 GDRTPGGILKHSSWRGLRTDKSVRDVELDLG--------- . * *:. * ** :.: