For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MQLPVMPPVSPMLAKSVTAIPPDASYEPKWDGFRSICFRDGDQVELGSRNERPMTRYFPELVAAIRAELP HRCVIDGEIIIATDHGLDFEALQQRIHPAESRVRMLADRTPASFIAFDLLALGDDDYTGRPFSERRAALV DAVTGSGADADLSIHVTPATTDMATAQRWFSEFEGAGLDGVIAKPPHITYQPDKRVMFKIKHLRTADCVV AGYRVHKSGSDAIGSLLLGLYQEDGQLASVGVIGAFPMAERRRLLTELQPLVTSFDDHPWNWAAHVAGQR TPRKNEFSRWNVGKDLSFVPLRPERVVEVRYDRMEGARFRHTAQFNRWRPDRDPRSCSYAQLERPLTVSL SDIVPGLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3731 | ligC | - | 100% (358) | ATP-dependent DNA ligase |
| M. tuberculosis H37Rv | Rv0938 | - | 2e-19 | 29.13% (333) | ATP-dependent DNA ligase |
| M. tuberculosis H37Rv | Rv3062 | ligB | 6e-13 | 28.14% (366) | ATP-dependent DNA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3758 | ligC | 0.0 | 99.72% (358) | ATP-dependent DNA ligase |
| M. gilvum PYR-GCK | Mflv_1254 | ligC | 1e-158 | 76.19% (357) | ATP-dependent DNA ligase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0279c | ligC | 1e-164 | 80.06% (346) | ATP-dependent DNA ligase |
| M. marinum M | MMAR_5266 | ligC | 0.0 | 85.71% (357) | ATP-dependent DNA ligase LigC |
| M. avium 104 | MAV_0360 | ligC | 0.0 | 87.50% (352) | ATP-dependent DNA ligase |
| M. smegmatis MC2 155 | MSMEG_6304 | ligC | 1e-153 | 76.08% (347) | ATP-dependent DNA ligase |
| M. thermoresistible (build 8) | TH_3157 | - | 9e-94 | 50.82% (366) | PUTATIVE DNA ligase |
| M. ulcerans Agy99 | MUL_4340 | ligC | 1e-177 | 84.03% (357) | ATP-dependent DNA ligase |
| M. vanbaalenii PYR-1 | Mvan_5549 | ligC | 1e-161 | 77.87% (357) | ATP-dependent DNA ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1254|M.gilvum_PYR-GCK MAGMRLPVMPPLSPMLSKSVQQIPDGA---SYEPKWDGFRSIVFRDGDEI
Mvan_5549|M.vanbaalenii_PYR-1 ---MQLPVMPPVSPMLSKSVDTIPDGA---SYEPKWDGFRSILFRDGNEV
MSMEG_6304|M.smegmatis_MC2_155 ---MDLPVLPPVSPMLSKSVNQIPPGM---SYEPKWDGFRSILFRDGAEV
Rv3731|M.tuberculosis_H37Rv ---MQLPVMPPVSPMLAKSVTAIPPDA---SYEPKWDGFRSICFRDGDQV
Mb3758|M.bovis_AF2122/97 ---MQLPVMPPVSPMLAKSVTAIPPDA---SYEPKWDGFRSICFRDGDQV
MAV_0360|M.avium_104 --------MPPVSPMLAKSVGAIPPAA---SYEPKWDGFRSICFRDGDEV
MMAR_5266|M.marinum_M ---MDLPVMPPISPMLAKAVKTIPADA---SYEPKWDGFRSICFRDNDEV
MUL_4340|M.ulcerans_Agy99 ---MDLPVMPPISPMLAKAVKTIPADA---SYEPKWDGFRSICFRDNDEV
MAB_0279c|M.abscessus_ATCC_199 --------------MLAKPVAKIPDGA---SYEPKWDGFRSIVFRDGDEV
TH_3157|M.thermoresistible__bu MGRVDLPVLPPLEPMLAKAQAEVPDEPGVWSYEPKWDGFRALVFRDGDEV
**:*. :* **********:: ***. ::
Mflv_1254|M.gilvum_PYR-GCK EFGSRNERPMTRYFPELVAAARSELPPRCVVDGEIVIATAGG----LDFE
Mvan_5549|M.vanbaalenii_PYR-1 ELGSRNERPMTRYFPELVEAARAELPPRCVVDGEIVVATGGG----LDFE
MSMEG_6304|M.smegmatis_MC2_155 ELGSRKERPMTRYFPELVAAALTELPDRCVIDGEIVLPADNH----LDFE
Rv3731|M.tuberculosis_H37Rv ELGSRNERPMTRYFPELVAAIRAELPHRCVIDGEIIIATDHG----LDFE
Mb3758|M.bovis_AF2122/97 ELGSRNERPMTRYFPELVAAIRAELPHRCVIDGEIIIATDHG----LDFE
MAV_0360|M.avium_104 ELGSRNERPMTRYFPELVAAVRAELPQRCVIDGEIVIATDHG----LDFE
MMAR_5266|M.marinum_M ELGSRNERPLTRYFPELVAAVRAELPRRCVLDGEIVIATGHG----LDFE
MUL_4340|M.ulcerans_Agy99 ELGSRNERPLTRYFPELVAAVRAELPRRCVLDGEIVIATGHG----LDFE
MAB_0279c|M.abscessus_ATCC_199 ELGSRNEKPLTRYFPELVAAVLAELPPRCVVDGEIVIATEAG----LDFE
TH_3157|M.thermoresistible__bu MLQSRNGRELGRYFPELVEALRDELADRCVLDGEVVVPREIDGRVRLDWE
: **: : : ******* * **. ***:***:::. **:*
Mflv_1254|M.gilvum_PYR-GCK ALQLRLHPAASRVTMLAEKTPASFIAFDLLALGDTDLTGRPFTERRAALV
Mvan_5549|M.vanbaalenii_PYR-1 ALQLRLHPAASRVRMLAEKTPASFIAFDLLALDDTDYTARPFAERRAALV
MSMEG_6304|M.smegmatis_MC2_155 ALQLRLHPAASRVAMLAEQTPAAFIAFDLLALGDDDYTGRPFSERRAALE
Rv3731|M.tuberculosis_H37Rv ALQQRIHPAESRVRMLADRTPASFIAFDLLALGDDDYTGRPFSERRAALV
Mb3758|M.bovis_AF2122/97 ALQQRIHPAESRVRMLADRTPASFIAFDLLALGDDDYTGRPFSERRAALV
MAV_0360|M.avium_104 ALQQRIHPAESRVRMLAEATPASFIAFDLLALGDEDYTGRPFRERRAALL
MMAR_5266|M.marinum_M ALQQRIHPADSRVRMLAEHTPASFIAFDLLALGDDDYTTRPFVERRAALV
MUL_4340|M.ulcerans_Agy99 ALQQRIHHADSRVRMLAEHIPASFIAFDLLALGDDDYTTRPFVERRAALV
MAB_0279c|M.abscessus_ATCC_199 ALQQRIHPADSRVRLLAEQTPSSFIAFDLLALGDEDYTGRPFSERRAALT
TH_3157|M.thermoresistible__bu SLSQRIHPAASRVAMLAEQTPAHFIGFDALATGATSLLDEPFRVRRDALN
:*. *:* * *** :**: *: **.** ** . . .** ** **
Mflv_1254|M.gilvum_PYR-GCK DALAGAGP----TFHVTPATRDIALATRWFDEFEGAGLDGVIAKPVDGVY
Mvan_5549|M.vanbaalenii_PYR-1 GALAGCGP----TFHVTPATLDVATARRWFDEFEGAGLDGVIAKPLDGHY
MSMEG_6304|M.smegmatis_MC2_155 TALADAGP----TFHLTPATTDLPTAQRWFHEFEGAGLDGVIAKPLDLTY
Rv3731|M.tuberculosis_H37Rv DAVTGSGADADLSIHVTPATTDMATAQRWFSEFEGAGLDGVIAKPPHITY
Mb3758|M.bovis_AF2122/97 DAVTGSGADADLSIHVTPATTDMATAQRWFSEFEGAGLDGVIAKPPHITY
MAV_0360|M.avium_104 EAVGGPGP----SIHVTPATTDLDTARRWFDEFEGAGLDGVVAKPLDITY
MMAR_5266|M.marinum_M EAVG-SGP----SIHVTPATTDQATARRWFEEFEGAGLDGVIAKPLAVTY
MUL_4340|M.ulcerans_Agy99 EAVG-SGP----SIHVTPATTDQATARRWFEEFEGAGLDGVIAKPLAVTY
MAB_0279c|M.abscessus_ATCC_199 EALSSAGT----SIHLTPATTDQALAQRWFEEFEGAGTDGLIAKPLAIAY
TH_3157|M.thermoresistible__bu EAVRSKQW-----CHVTRTTEDPELGAEWLQAFEGAGLDGVIAKRLDGPY
*: *:* :* * . .*: ***** **::** *
Mflv_1254|M.gilvum_PYR-GCK LPDKRTMFKIKHRRTADCVVAGYRLHKSGDDAVGSLLLGLYDSDGALASV
Mvan_5549|M.vanbaalenii_PYR-1 LPDKRVMFKIKHQRTADCVVAGYRLHKSGPDAVGSLLLGLYDDDGSLASV
MSMEG_6304|M.smegmatis_MC2_155 QPDKRVMFKVKHQRTADCVVAGYRLHKSGADAVGSLLLGLYDDDGSLASV
Rv3731|M.tuberculosis_H37Rv QPDKRVMFKIKHLRTADCVVAGYRVHKSGSDAIGSLLLGLYQEDGQLASV
Mb3758|M.bovis_AF2122/97 QPDKRVMFKIKHLRTADCVVAGYRVHKSGSDAIGSLLLGLYQEDGQLASV
MAV_0360|M.avium_104 QPDKRVMFKIKHERTADCVVAGYRVHKSGADAIGSLLLGLYQDDGQLASV
MMAR_5266|M.marinum_M QPDKRVMFKIKHERTADCVLAGYRLHKSGGDVIGSLLLGLYQDDGQLASV
MUL_4340|M.ulcerans_Agy99 QPDKCVMFKLKHERTADCVLAGYRLHKSGGDVIGSLLLGLYQDDGQLASV
MAB_0279c|M.abscessus_ATCC_199 QPDKRVMFKIKPERTADCVVAGYRVHKSGDDAIGSLLLGLYQEDGILASV
TH_3157|M.thermoresistible__bu LPGKREMVKVKHVRDADCVAIGYRIHKSG-EGVGSILLGLYTEDGELRMV
*.* *.*:* * **** ***:**** : :**:***** .** * *
Mflv_1254|M.gilvum_PYR-GCK GVIGAFPMARRRALLAELQPLVTTFDEHPWNWAAH--ADPDVVRRHGGGS
Mvan_5549|M.vanbaalenii_PYR-1 GVVGAFPMARRRELVTELQPLVTTFDGHPWNWAAQ--VDPDTVRRYGGGS
MSMEG_6304|M.smegmatis_MC2_155 GVIGAFPMATRRALFTELQTLVADFDHHPWNWAAQAAADPELARRYGGGS
Rv3731|M.tuberculosis_H37Rv GVIGAFPMAERRRLLTELQPLVTSFDDHPWNWAAH--VAGQRTPRKNEFS
Mb3758|M.bovis_AF2122/97 GVIGAFPMAERRRLLTELQPLVTSFDDHPWNWAAH--VAGQRTPRKNEFS
MAV_0360|M.avium_104 GVIGAFPMAERRRLFTELQPLVTDFEDHPWNWAAH--QAGERTPRKNEFS
MMAR_5266|M.marinum_M GVIGAFPMAERRRLFTELQELVTSFDDHPWNWAAH--QSGERTPRKNEFS
MUL_4340|M.ulcerans_Agy99 GVIGAFPMAERRRLFTELQELVTSFDDHPWNWAAH--QSGERTPRKNEFS
MAB_0279c|M.abscessus_ATCC_199 GVIGAFPMAERKRLFQELQPLIIPLENHPWNWAAH--EAGERTPQKNAGS
TH_3157|M.thermoresistible__bu GGAASFTARNRLRLLADLQPLRIG-----------------NELREGEPS
* .:*. * *. :** * : . *
Mflv_1254|M.gilvum_PYR-GCK RWNAGKDLSFVPLRPERVVEVRYDHMEG-----RRFRHMAQFNRWRPDRT
Mvan_5549|M.vanbaalenii_PYR-1 RWNAGKDLSFVPLRPERVVEVRYDHMEG-----QRFRHTAQFNRWRPDRD
MSMEG_6304|M.smegmatis_MC2_155 RWNAGKDLSFVPLRPERLVEVRYDHMEG-----RRFRHTAQFNRWRPDRD
Rv3731|M.tuberculosis_H37Rv RWNVGKDLSFVPLRPERVVEVRYDRMEG-----ARFRHTAQFNRWRPDRD
Mb3758|M.bovis_AF2122/97 RWNVGKDLSFVPLRPERVVEVRYDHMEG-----ARFRHTAQFNRWRPDRD
MAV_0360|M.avium_104 RWNAGKDLSFVPLRPERVVEVRYDHMEG-----RRFRHTAQFNRWRPDRD
MMAR_5266|M.marinum_M RWNAGKDLSFVPLRPERVVEVRYDHMEG-----PRFRHTAQFNRWRPDRD
MUL_4340|M.ulcerans_Agy99 RWNAGKDLSFVPLRPERVVEVRYDHMEG-----PRFRHTAQFNRWRPDRD
MAB_0279c|M.abscessus_ATCC_199 RWNAGKDLSFVPLRPERVVEVRYDHMEG-----VRFRHTAQFNRWRPDRD
TH_3157|M.thermoresistible__bu RWNSAADKRWIPVRPEKVCEVVYDQMEGNSVDGRRFRHAVRFVRWRPDRD
*** . * ::*:***:: ** **:*** **** .:* ******
Mflv_1254|M.gilvum_PYR-GCK PRSCTFDQLEQPVSFSLDDIGPGLTPRAGRPYRS------
Mvan_5549|M.vanbaalenii_PYR-1 PLSCTFDQLDRPLTFSLDDIVPGLG--GTRPRG-------
MSMEG_6304|M.smegmatis_MC2_155 ARSCTFAQLDSPPHSSSVTSCRV-----------------
Rv3731|M.tuberculosis_H37Rv PRSCSYAQLERPLTVSLSDIVPGLR---------------
Mb3758|M.bovis_AF2122/97 PRSCSYAQLERPLTVSLSDIVPGLR---------------
MAV_0360|M.avium_104 PRSCTYEQLEQPVTFRLGDIVPGLGASRADHKPGKQIGAP
MMAR_5266|M.marinum_M PRSCTYAQLEQPLTFSLDDIVAGLG-PRCGH---------
MUL_4340|M.ulcerans_Agy99 PRSCTYAQLEQPLMFNLDDIVAGLG-PRCGH---------
MAB_0279c|M.abscessus_ATCC_199 PRSCTYEQLEQPITFSLNDIVPGLV---------------
TH_3157|M.thermoresistible__bu PRSCTFAQLEVPLHYDLYDVLEQA----------------
. **:: **: *