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GGTSSRLAKVERIAELLRAAAPDPELVAIVVAWLSGELRQRQIGVGWAALRSLPAAAGSPALTVTGTDAA FSEIGAVSGKGSAARRRELITRLFAAATETEQAFLVRLLSGELRQGALAGIMVDAVARAAEVPATAVQRA AMLGGDLPTVAAACLAAGSSGAAGALDSFTLRVGRPIGPMLAQSAGSITVALERHGGATIFEAKLDGARV QIHRTGDEVTVYTRSLDDVTARLPEVVQATLALPVSDLVADGEAIALQPDGRPHRFQVTASRFGRSVNVA AAQAKQPLSVFFFDILHRDGRDLLDAPTTDRLAALDAVVPARHRVDRLTTADAAAATDFLRATLAAGHEG VMAKSPTAPYLAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDAATGEFVMLGKTFKG MTDAMLDWQTARFTELAVGGTDGYVVALRPEQVVEVAFDGVQASSRYPGGLALRFARVVRYRDDKGPADA DTIDTVRALY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1623 | ligB | - | 100% (501) | ATP-dependent DNA ligase LigB |
| M. marinum M | MMAR_4573 | - | 2e-15 | 31.72% (227) | ATP dependent DNA ligase |
| M. marinum M | MMAR_5266 | ligC | 3e-11 | 27.46% (346) | ATP-dependent DNA ligase LigC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3089 | ligB | 0.0 | 79.64% (501) | ATP-dependent DNA ligase |
| M. gilvum PYR-GCK | Mflv_4321 | ligB | 0.0 | 70.72% (502) | ATP-dependent DNA ligase |
| M. tuberculosis H37Rv | Rv3062 | ligB | 0.0 | 79.44% (501) | ATP-dependent DNA ligase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0279c | ligC | 3e-12 | 27.53% (316) | ATP-dependent DNA ligase |
| M. avium 104 | MAV_3937 | ligB | 0.0 | 81.94% (504) | ATP-dependent DNA ligase |
| M. smegmatis MC2 155 | MSMEG_2277 | ligB | 0.0 | 68.79% (503) | ATP-dependent DNA ligase |
| M. thermoresistible (build 8) | TH_1632 | ligB | 0.0 | 71.86% (501) | PROBABLE ATP-DEPENDENT DNA LIGASE LIGB |
| M. ulcerans Agy99 | MUL_3413 | ligB | 0.0 | 98.20% (501) | ATP-dependent DNA ligase |
| M. vanbaalenii PYR-1 | Mvan_2025 | ligB | 0.0 | 68.83% (523) | ATP-dependent DNA ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1623|M.marinum_M --------------------------MGGTSSRLAKVERIAELLRAAAPD
MUL_3413|M.ulcerans_Agy99 --------------MLLIDIASTSLNVGGTSSRLAKVARIAEPLRAAAPD
MAV_3937|M.avium_104 ----MSPSHAKLATVLLFDVATASADVGGTPSRLTKVARIADLLRRAAPD
Mb3089|M.bovis_AF2122/97 --------------MLLHDVAITSMDVAATSSRLTKVARIAALLHRAAPD
Rv3062|M.tuberculosis_H37Rv --------------MLLHDVAITSMDVAATSSRLTKVARIAALLHRAAPD
MSMEG_2277|M.smegmatis_MC2_155 ---------------MLADVAAASTEVAASSARLVKIERIATLLARSAAE
TH_1632|M.thermoresistible__bu MSARAGRRPCQADQMLLVDVATASAEVGATTARSAKISRIAELLR----D
Mflv_4321|M.gilvum_PYR-GCK --------------MLLVDVAGASADVAASSARLAKIARIAELLRRAGRE
Mvan_2025|M.vanbaalenii_PYR-1 --------------MLLVDVANASADVAAMSARLAKVARIAELLRTAGRQ
MAB_0279c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1623|M.marinum_M PE--LVAIVVAWLSGELRQRQIGVGWAALRSLPAAAGSPALTVTGTDAAF
MUL_3413|M.ulcerans_Agy99 PE--LVAIVVAWLSGELRQRQIGVGWATLRSPPAAAGSPALTVTGTDAAF
MAV_3937|M.avium_104 AA--LVAIVVSWLSGELRQRQIGVGWAALRSRPPAAAHPTLTVVAVDAAF
Mb3089|M.bovis_AF2122/97 TQ--LVTIIVSWLSGELPQRHIGVGWAALRSLPPPAPQPALTVTGVDATL
Rv3062|M.tuberculosis_H37Rv TQ--LVTIIVSWLSGELPQRHIGVGWAALRSLPPPAPQPALTVTGVDATL
MSMEG_2277|M.smegmatis_MC2_155 DDTQAVAVIVSWLSGELPQRQIGVGWAALRTLPPPAATPSLTVDDVDDRL
TH_1632|M.thermoresistible__bu TDAALVPVVVSWLSGELPQRPIGVGWAALRSLPPPAAAPTLTVAAVDAAF
Mflv_4321|M.gilvum_PYR-GCK D----VAIVVSWLSGELTQRQIGVGWASLRSVPAAAAEPTLTVAEVERRF
Mvan_2025|M.vanbaalenii_PYR-1 GDARLVRVVVSWLSGELTQRQIGVGWRSVRSVPDPAAQPSLTVEDVDARF
MAB_0279c|M.abscessus_ATCC_199 -------MLAKPVAKIPDGASYEPKWDGFRS-----------IVFRDGDE
::. :: * .*: : :
MMAR_1623|M.marinum_M SEIGAVSGKGSAARRRELITRLFAAATETEQAFLVRLLSGELRQGALAGI
MUL_3413|M.ulcerans_Agy99 SEIGAVSGKGSAARRRELITRLFAASTETEQAFLVRLLSGELRQGALAGI
MAV_3937|M.avium_104 AEIGAVAGKGAQARRAALLNALFAAATETEQTFLLRLLGGELRQGALAGI
Mb3089|M.bovis_AF2122/97 SKIGTLSGKGSQAQRAALVAELFSAATEAEQTFLLRLLGGELRQGAKGGI
Rv3062|M.tuberculosis_H37Rv SKIGTLPGKGSQAQRAALVAELFSAATEAEQTFLLRLLGGELRQGAKGGI
MSMEG_2277|M.smegmatis_MC2_155 STIKAVAGKGSQATRAGLVHELFSAATDPEQKFLRHLLSGELRQGALAGV
TH_1632|M.thermoresistible__bu TQIRTVTGKGSQARRAALLAELFGAATGIEQRFLRGLLSGELRQGALVGV
Mflv_4321|M.gilvum_PYR-GCK GEIGATAGRGSQARRAQLLADLFSAATDVEQTFLRRLLTGELRQGALVGV
Mvan_2025|M.vanbaalenii_PYR-1 GEIGSTSGKGSQARRAALLAELFAAATAVEQVFLRRLLTGELRQGALGGV
MAB_0279c|M.abscessus_ATCC_199 VELGSRNEKPLTRYFPELVAAVLAELPP------RCVVDGEIVIATEAGL
: : : *: ::. . :: **: .: *:
MMAR_1623|M.marinum_M MVDAVARAAEVPATAVQRAAMLGGDLPTVAAACL---AAGSSGAAGALDS
MUL_3413|M.ulcerans_Agy99 MVDAVARAAEVPATAVQRAAMLGGDLPTVAAACL---AAGSSGAAGALDS
MAV_3937|M.avium_104 MADAVARAAGIPAAAVQRAAMLGGDLPAVAAAALSGEAAALSGEASALDA
Mb3089|M.bovis_AF2122/97 MADAVAQAAGLPAATVQRAAMLGGDLAAAAAAGL---------SGAALDT
Rv3062|M.tuberculosis_H37Rv MADAVAQAAGLPAATVQRAAMLGGDLAAAAAAGL---------SGAALDT
MSMEG_2277|M.smegmatis_MC2_155 MADAVAKAAGLPAAEIRRAAMLAGNLPAVAAAAVT-------GGRAALAD
TH_1632|M.thermoresistible__bu MADAVARAADVPAAAVRRAAMLAGELPTVAGAALT-------GGTDALSR
Mflv_4321|M.gilvum_PYR-GCK MADAVAKAADLPAATVRRAAMLGGDLPAVAAAALT-------DGDAGLAQ
Mvan_2025|M.vanbaalenii_PYR-1 MADAVGKAAGVPSAVVRRAAMLGGDLPAVAAAAVT-------DGESALAQ
MAB_0279c|M.abscessus_ATCC_199 DFEALQQRIHPADSRVR---LLAEQTPS---------------SFIAFDL
:*: : . : :: :*. : .: .:
MMAR_1623|M.marinum_M FTLRVGRPIGPMLAQSAGSITVALERHGGATIFEAKLDGARVQIHRTGDE
MUL_3413|M.ulcerans_Agy99 FTLRVGRPIGPMLAQSAGSITDALERHGGATIFEAKLDGARVQIHRTGDE
MAV_3937|M.avium_104 FTLRVGRPVAPMLAQTAAGVAEAIERHGGQAIFEAKLDGARVQIHRAGDQ
Mb3089|M.bovis_AF2122/97 FTLRVGRPIGPMLAQTATSVHDALERHGGTTIFEAKLDGARVQIHRANDQ
Rv3062|M.tuberculosis_H37Rv FTLRVGRPIGPMLAQTATSVHDALERHGGTTIFEAKLDGARVQIHRANDQ
MSMEG_2277|M.smegmatis_MC2_155 FRLRVGRPVGPMLAQTATSVDDALQRLGGTAVLEAKLDGARVQIHRSGCD
TH_1632|M.thermoresistible__bu YTLRVGQPVGPMLAQTAAGVTEALERLGGTAVLEAKLDGARVQIHRSRRE
Mflv_4321|M.gilvum_PYR-GCK FTLQAGKAVGPMLAQTAADVTDALDRLGGTAMFEAKLDGARVQIHRRGDS
Mvan_2025|M.vanbaalenii_PYR-1 FTLQVGRPVGPMLAQTATGVADALDRFGGTALFEAKLDGARVQIHRRGDA
MAB_0279c|M.abscessus_ATCC_199 LALGDEDYTGRPFSERRAALTEALSSAG-----------TSIHLTPATTD
* . ::: : *:. * : :::
MMAR_1623|M.marinum_M VTVYTRSLDDVTARLPEVVQATLALPVSDLVADGEAIALQPDGRPHRFQV
MUL_3413|M.ulcerans_Agy99 VTVYTRSLDDVTARLPEVVQATLALPVSDLVADGEAIALQPDGRPHRFQV
MAV_3937|M.avium_104 VTVYTRSLDDVTARLPEVVTATLALPVEALIADGEAIALRPDNSPQRFQV
Mb3089|M.bovis_AF2122/97 VRIYTRSLDDVTARLPEVVEATLALPVRDLVADGEAIALCPDNRPQRFQV
Rv3062|M.tuberculosis_H37Rv VRIYTRSLDDVTARLPEVVEATLALPVRDLVADGEAIALCPDNRPQRFQV
MSMEG_2277|M.smegmatis_MC2_155 VSIYTRSLDDVTHRLPEVVEATLALPATELIADAEAIALRPDGRPHLFQV
TH_1632|M.thermoresistible__bu VAIFTRSLDDVTARLPEVVEAALTWPVSEVIADAEAIALRPDGRPHRFQV
Mflv_4321|M.gilvum_PYR-GCK VSIFTRSLDDVTARLPEVVEATLALPVTDLIADAEAIALRPDGRPHRFQV
Mvan_2025|M.vanbaalenii_PYR-1 VSVFTRSLDDVTARLPEVVDATLALPVTELIADAEAIALRPDGRPHRFQI
MAB_0279c|M.abscessus_ATCC_199 QALAQRWFEEFEG-----------AGTDGLIAKPLAIAYQPDKR-VMFKI
: * :::. . ::*. *** ** *::
MMAR_1623|M.marinum_M TASRFGRSVNVAAAQAKQPLSVFFFDILHRDGRDLLDAPTTDRLAALDAV
MUL_3413|M.ulcerans_Agy99 TASRFGRSVNVAAAQAKQPLSVFFSDILHRDGRDLLDAPTTDRLAALDAV
MAV_3937|M.avium_104 TASRFGRSVDVAAAVAAQPLSVFFFDILHCDGVDLLDAPTTDRLAALDAL
Mb3089|M.bovis_AF2122/97 TASRFGRSVDVAAARATQPLSVFFFDILHRDGTDLLEAPTTERLAALDAL
Rv3062|M.tuberculosis_H37Rv TASRFGRSVDVAAARATQPLSVFFFDILHRDGTDLLEAPTTERLAALDAL
MSMEG_2277|M.smegmatis_MC2_155 TAARFGRKD----PGDLGPLSVFFFDLLHVDGRDLLDLPTEERFGALDAL
TH_1632|M.thermoresistible__bu TASRFGRAG----PGAAPPLSVFVFDLLHVDGDDLLDRPTGARLEVLDAL
Mflv_4321|M.gilvum_PYR-GCK TASRFGRRGGTS-DTASNPLSVFFFDLLHVDGVDLLDAPAHERIARLDAV
Mvan_2025|M.vanbaalenii_PYR-1 TASRFGRRGGTP-DAGTQRLSVFFFDLLHADGVDLLDLPTGERIATLDAT
MAB_0279c|M.abscessus_ATCC_199 KPERT-----------------------------------------ADCV
.. * *.
MMAR_1623|M.marinum_M VPARHRVDRLTTADAAAATDFLRATLAAGHEGVMAKSPTAPYLAGRRGAG
MUL_3413|M.ulcerans_Agy99 VPARHRVDRLTTADAAAATDFLRATLAAGHEGVMAKSPTAPYLAGRRGAG
MAV_3937|M.avium_104 VPPAQRVDQLLTADPDAAGRFLEATLAAGHEGVMAKAPGAPYQAGRRGAG
Mb3089|M.bovis_AF2122/97 VPARHRVDRLITSDPTDAANFLDATLAAGHEGVMAKAPAARYLAGRRGAG
Rv3062|M.tuberculosis_H37Rv VPARHRVDRLITSDPTDAANFLDATLAAGHEGVMAKAPAARYLAGRRGAG
MSMEG_2277|M.smegmatis_MC2_155 VRQDQRVDRLVTTDTVAAQEFLERTLAAGHEGVMAKSPHAAYEAGRRGAG
TH_1632|M.thermoresistible__bu IPDRHRVDRLVTADPAAAERFLRATLDAGHEGVMAKSPSAAYEAGRRGAG
Mflv_4321|M.gilvum_PYR-GCK TPDSQRVDRLVTSDPGAAQEFFDRTLAAGHEGVMAKSTVAPYEAGRRGAG
Mvan_2025|M.vanbaalenii_PYR-1 VPREQRVDRLLTSDPEAAQAFLDATLAAGHEGVMAKSPTAPYEAGRRGAG
MAB_0279c|M.abscessus_ATCC_199 VAG----YRVHKSGDDAIGSLLLGLYQE--DGILASVGVIGAFPMAERKR
:: .:. :: :*::*. . .
MMAR_1623|M.marinum_M WLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDAATGEFVMLGKTF
MUL_3413|M.ulcerans_Agy99 WLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIPLGARDAATGEFVMLGKTF
MAV_3937|M.avium_104 WLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGEFVMVGKTF
Mb3089|M.bovis_AF2122/97 WLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTF
Rv3062|M.tuberculosis_H37Rv WLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTF
MSMEG_2277|M.smegmatis_MC2_155 WLKVKPVHTLDLVVLAVEWGSGRRQGKLSNIHLGARDPDSSGFVMLGKTF
TH_1632|M.thermoresistible__bu WLKVKPVHTLDVVVLAVEWGSGRRAGKLSNIHLGARDPRTGGFVMLGKTF
Mflv_4321|M.gilvum_PYR-GCK WLKVKPVHTLDLVVLAVEWGSGRRSGKLSNIHLGARDPGTGGFVMLGKTF
Mvan_2025|M.vanbaalenii_PYR-1 WLKVKPVHTLDLVVLAVEWGSGRRTGKLSNIHLGARDPATGGFVMLGKTF
MAB_0279c|M.abscessus_ATCC_199 LFQELQPLIIPLENHPWNWAAHEAGERTPQKNAGSR--------------
:: : : . :*.: . : .: *:*
MMAR_1623|M.marinum_M KGMTDAMLDWQTARFTELAVG--------------------GTDGYVVAL
MUL_3413|M.ulcerans_Agy99 KSMTDAMLDWQTARFTELAVG--------------------GTDGYVVAL
MAV_3937|M.avium_104 KGMTDAMLDWQTARFTELAVG--------------------GTDGYVVRV
Mb3089|M.bovis_AF2122/97 KGMTDAMLDWQTTRFHEIAVG--------------------PTDGYVVQL
Rv3062|M.tuberculosis_H37Rv KGMTDAMLDWQTTRFHEIAVG--------------------PTDGYVVQL
MSMEG_2277|M.smegmatis_MC2_155 KGMTDAMLEWQTQRFLELADG--------------------PTDGYVVHL
TH_1632|M.thermoresistible__bu KGMTDAMLEWQTARFLELADG--------------------PTTGHVVRL
Mflv_4321|M.gilvum_PYR-GCK KGMTDEMLAWQTRRFLDLADG-------------------DATDHYVVKV
Mvan_2025|M.vanbaalenii_PYR-1 KGMTDEMLAWQTERFLELADGAAPAATADHGAAPAATADHGAADGFTVTV
MAB_0279c|M.abscessus_ATCC_199 ---------WNAG-----------------------------KDLSFVPL
*:: * :
MMAR_1623|M.marinum_M RPEQVVEVAFDGVQ-----ASSRYPGGLALRFARVVRYRDDKGPADADTI
MUL_3413|M.ulcerans_Agy99 RPEQVVEVAFDGVQ-----ASSRYPGGLALRFARVVRYRDDKGPADADTI
MAV_3937|M.avium_104 RPEQVVEVAVDGVQ-----KSSRYPGGLALRFARVLRYRDDKGPAEADTI
Mb3089|M.bovis_AF2122/97 RPEQVVEVALDGVQ-----RSSRYPGGLALRFARVVRYRADKDPAEADTI
Rv3062|M.tuberculosis_H37Rv RPEQVVEVALDGVQ-----RSSRYPGGLALRFARVVRYRADKDPAEADTI
MSMEG_2277|M.smegmatis_MC2_155 RPEQVVEIAFDGVQ-----RSSRYPAGMALRFVRVLRYRDDKSPAEADTV
TH_1632|M.thermoresistible__bu RPEQVVEIAFDGVQ-----RSSRYPGGMALRFARVLRYRDDKTPDEADTV
Mflv_4321|M.gilvum_PYR-GCK RPEQVVEIAFDGLQ-----TSTRYPGGMALRFARVVRYRDDKAATDADTI
Mvan_2025|M.vanbaalenii_PYR-1 RPEQVVEIAFDGIQ-----TSSRYPGGMALRFARVLCYRDDKTAAEADTI
MAB_0279c|M.abscessus_ATCC_199 RPERVVEVRYDHMEGVRFRHTAQFNRWRPDRDPRSCTYEQLEQPITFSLN
***:***: * :: :::: . * * *. : . .
MMAR_1623|M.marinum_M DTVRALY----
MUL_3413|M.ulcerans_Agy99 DTVRALY----
MAV_3937|M.avium_104 DAVRALY----
Mb3089|M.bovis_AF2122/97 DAVRALY----
Rv3062|M.tuberculosis_H37Rv DAVRALY----
MSMEG_2277|M.smegmatis_MC2_155 ETVRRFYERD-
TH_1632|M.thermoresistible__bu DTVRRIYERGD
Mflv_4321|M.gilvum_PYR-GCK DTVREIYERGN
Mvan_2025|M.vanbaalenii_PYR-1 DTVRALHERAN
MAB_0279c|M.abscessus_ATCC_199 DIVPGLV----
: * :