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M. tuberculosis H37Rv Rv2935 (ppsE)

annotation: PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE
coordinates: 3267737 - 3272203
length: 1488

VSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKESIVTLSEQELRDAGVSDKTLADPAYVRRAPLLDGI
DEFDAGFFGFPPLAAQVLDPQHRLFLQCAWHALEDAGADPARFDGSIGVYGTSSPSGYLLHNLLSHRDPN
AVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVAVHLACLSLLSGECDMALAGG
SSLCIPHRVGYFTSPGSMVSAVGHCRPFDVRADGTVFGSGVGLVVLKPLAAAIDAGDRIHAVIRGSAINN
DGSAKMGYAAPNPAAQADVIAEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQGLRAAFEVSQTSRSAPC
VLGSVKSNIGHLEVAAGIAGLIKTILCLKNKALPATLHYTSPNPELRLDQSPFVVQSKYGPWECDGVRRA
GVSSFGVGGTNAHVVLEEAPAEASEVSAHAEPAGPQVILLSAQTAAALGESRTALAAALETQDGPRLSDV
AYTLARRRKHNVTMAAVVHDREHAATVLRAAEHDNVFVGEAAHDGEHGDRADAAPTSDRVVFLFPGQGAQ
HVGMAKGLYDTEPVFAQHFDTCAAGFRDETGIDLHAEVFDGTATDLERIDRSQPALFTVEYALAKLVDTF
GVRAGAYIGYSTGEYIAATLAGVFDLQTAIKTVSLRARLMHESPPGAMVAVALGPDDVTQYLPPEVELSA
VNDPGNCVVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHTSAMDPMLGQFQEFLSRQQLRPPRTPLLSN
LTGSWMSDQQVVDPASWTRQISSPIRFADELDVVLAAPSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRL
MRHPLQDVDDRDTFLRALGELWSAGVEVDWTPRRPAVPHLVSLPGYPFARQRHWVEPNHTVWAQAPGANN
GSPAGTADGSTAATVDAARNGESQTEVTLQRIWSQCLGVSSVDRNANFFDLGGDSLMAISIAMAAANEGL
TITPQDLYEYPTLASLTAAVDASFASSGLAKPPEAQANPAVPPNVTYFLDRGLRDTGRCRVPLILRLDPK
IGLPDIRAVLTAVVNHHDALRLHLVGNDGIWEQHIAAPAEFTGLSNRSVPNGVAAGSPEERAAVLGILAE
LLEDQTDPNAPLAAVHIAAAHGGPHYLCLAIHAMVTDDSSRQILATDIVTAFGQRLAGEEITLEPVSTGW
REWSLRCAALATHPAALDTRSYWIENSTKATLWLADALPNAHTAHPPRADELTKLSSTLSVEQTSELDDG
RRRFRRSIQTILLAALGRTIAQTVGEGVVAVELEGEGRSVLRPDVDLRRTVGWFTTYYPVPLACATGLGA
LAQLDAVHNTLKSVPHYGIGYGLLRYVYAPTGRVLGAQRTPDIHFRYAGVIPELPSGDAPVQFDSDMTLP
VREPIPGMGHAIELRVYRFGGSLHLDWWYDTRRIPAATAEALERTFPLALSALIQEAIAAEHTEHDDSEI
VGEPEAGALVDLSSMDAG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2935ppsE-100% (1488)PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE
M. tuberculosis H37RvRv1664pks9e-14435.36% (1018) polyketide synthase pks9
M. tuberculosis H37RvRv2048cpks12e-13536.53% (906) polyketide synthase pks12

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2960ppsE0.099.93% (1488) phenolpthiocerol synthesis type-I polyketide synthase PPSE
M. gilvum PYR-GCKMflv_3390-0.058.11% (1499) beta-ketoacyl synthase
M. leprae Br4923MLBr_02353-0.081.95% (1496) polyketide synthase
M. abscessus ATCC 19977MAB_2256-0.040.33% (1019) polyketide synthase
M. marinum MMMAR_1772ppsE0.081.37% (1492) phenolpthiocerol synthesis type-I polyketide synthase PpsE
M. avium 104MAV_1763-1e-14336.95% (939) tylactone synthase modules 4 & 5
M. smegmatis MC2 155MSMEG_0408-1e-14837.39% (952) type I modular polyketide synthase
M. thermoresistible (build 8)TH_4458-1e-12532.64% (1100) PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide
M. ulcerans Agy99MUL_2015ppsE0.080.97% (1492) phenolpthiocerol synthesis type-I polyketide synthase PpsE
M. vanbaalenii PYR-1Mvan_3123-0.059.33% (1485) beta-ketoacyl synthase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                MSTVEGLRDPASSFAIVGYAARFPGAADADEFWRVLAEGRDAVSEVPKDR
MSMEG_0408|M.smegmatis_MC2_155      MVSAEHPIEPTPSFAIIGYAARFPGAASAEEYWALLRDGREAISDVPKDR
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                WDADEFFDPDPDAPGKVVTRRAGFVDDVTGFDAPFFGMSAREARLLDPQH
MSMEG_0408|M.smegmatis_MC2_155      WDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPFFGMSAREVRLMDPQH
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                RLLLETAWRAVEHSGTAPTDLANTNTGVFIGISTHDYLGMASDELTYDQI
MSMEG_0408|M.smegmatis_MC2_155      RILMETAWRAVEHSGIAPTSLANSNTGVFVGLATHDYLGMASDELTYPEI
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                EAYTAIGTSSAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL
MSMEG_0408|M.smegmatis_MC2_155      EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                GECDLALAGGANVLLTPATMITFSQAHMLAPDGRCKTFDAAADGYVRGEG
MSMEG_0408|M.smegmatis_MC2_155      NECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                CGVLVVKRLEDAIRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA
MSMEG_0408|M.smegmatis_MC2_155      CGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                EALQRAGIAPGDVDYLEAHGTGTSLGDPIEVQAAGAVLGAGREASRPLLI
MSMEG_0408|M.smegmatis_MC2_155      DALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAGEVLGAGRAPEEPLLI
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                GSVKTNIGHLEAAAGIAGVIKVILALEHGMLPQHLHFRDPSPHIPWDRLA
MSMEG_0408|M.smegmatis_MC2_155      GSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHLNFETPSPHIPWERLP
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                VQVVKEATAWQRNGRPRVAGVSSFGFAGTNAHVILEEAPDGTGRAAVPPA
MSMEG_0408|M.smegmatis_MC2_155      IEVVRETVPWQRNGKPRIAGVSSFGFAGTNAHVILEEAP-AVGTPATTEP
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                AVRPPGQRRFHVLPLSARTPAALVQIAGEYRDWLSAHPDTALADLCLTAG
MSMEG_0408|M.smegmatis_MC2_155      VEDP---RRYSVLPLSARTPEALVRLAGEYRDWLRAHPQARLADVSHTAG
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                AGRAHFEHRAALVVDSTGSAGELLAALADDRPAPGLLRGVCEDAPKTAWL
MSMEG_0408|M.smegmatis_MC2_155      TARAHLEQRAALVVNSRESAIELLGALADDRPAPGLVRGESHEAPKTAWL
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                FTGQGSQYAGMARELFDTEPVFAETLTRCATVLADVLEKPLLDVIFDTDD
MSMEG_0408|M.smegmatis_MC2_155      FTGQGSQYPGMARELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDADE
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                P--ASEATLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSA
MSMEG_0408|M.smegmatis_MC2_155      LDGDTESPLRHTTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYSA
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                ACVAGVLRVEDGARLIAERGRLFGSLPAGGRMVAAFAAAARVEGLTDEFP
MSMEG_0408|M.smegmatis_MC2_155      ACVAGVFDVEDGARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEYP
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                SLSVAAYNGANTVLSGPGQELEQAVARLTAEKVRCDWLDTSHAFHSALLD
MSMEG_0408|M.smegmatis_MC2_155      SLSVAAYNGANTVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALLD
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                PILDEFESYANQFDFGPPQRILICNRTGSALGRSVKLDGAYWRRHARQPV
MSMEG_0408|M.smegmatis_MC2_155      PILDDFESFAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQPV
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                EFAKSVHTLADLGCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRRN
MSMEG_0408|M.smegmatis_MC2_155      EFAKSVRTLADMNCRVLLEIGPRPVLTATALAAWPDPATTPQVLASLRPT
TH_4458|M.thermoresistible__bu      ---------------------------------------------LLSLL
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                TADHRQITEALAEAYIVGHLPDFGAAVGP-ARKLDLPTYPFQHRQYWFSE
MSMEG_0408|M.smegmatis_MC2_155      TADHRQITEAVAAAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFSD
TH_4458|M.thermoresistible__bu      RQRSERYGDKIAFDYCTGEQEHSRLTYQELDIRARAIAAHLQDQGVAGER
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                QRVPPGSQQTS-------TQTTAVRLLEDGRIAELAELLDGASADQHTLD
MSMEG_0408|M.smegmatis_MC2_155      NRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTLR
TH_4458|M.thermoresistible__bu      VLVLCPSGLDFITAMFGCFYVGAVAVPVHPPVHNRLLSRVASIVADVRAT
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                VLTKLAAQHNQQRKSRSIAEDRYEIRWEKSTVPGP--EAEATWLVVGDDD
MSMEG_0408|M.smegmatis_MC2_155      VLNKLAARHNQQRSTHVDPDARYEIRWDAIASAAASTGAAADWILVGDDT
TH_4458|M.thermoresistible__bu      SVLTTAATRADLKEILDGLHDGDPLRWLAVDTIEADDETSWTPTTVDTDS
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                DAVAPLVDALTARGHQHRILVLPASDADEERLEIVLRAAAAEEAPLRIAL
MSMEG_0408|M.smegmatis_MC2_155      AAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAGE--LYVVH
TH_4458|M.thermoresistible__bu      VAFVQYTSGSTSTPKG-----------------VVLTHHNLLANLESISR
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                VAALDSGTAPSMRSLLRMQHRVLAGTRRLFRAAAAAELRQPIWLVTRGAQ
MSMEG_0408|M.smegmatis_MC2_155      IAAGDGAAAP-MRDLLRVQHRTLGGLRRLFRAANDAELRSPIWLVTRDGQ
TH_4458|M.thermoresistible__bu      DAGQGDEARVVSWLPLHHDMGLIGGIFGVVHFGGTAYLMPPSSFIQRPMS
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                RVTDADTVFPDQSCLWGFGRAASLEYPQLWGGLADLAQGSAEEWSRLVRV
MSMEG_0408|M.smegmatis_MC2_155      RVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLS-GADTEWPRLIAR
TH_4458|M.thermoresistible__bu      WLEAISWHGANISVGPNFG--------------YQLCVERSTPEERATLD
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                ASAPRDPAVGEDQIALRGSDIYVPRLTRRSGQPAAAALTLRADATYLVTG
MSMEG_0408|M.smegmatis_MC2_155      ITSPRD---GEDQIALRGDAVYAPRLVRRTGEPSDTPLPVREDRTYLVTG
TH_4458|M.thermoresistible__bu      LSTWVRAYCGAEPVRAATMRRFTEAFAPAGFRADAFHPVYGLAEATLFVS
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      ------------------------------------------------MQ
MAV_1763|M.avium_104                GLGSIGLEIAGHLAAQGARHLVLTGRRAPGEAAQRRIDALSQQHGCEVRV
MSMEG_0408|M.smegmatis_MC2_155      GLGAIGLEVAGYLASHGAGHVVLTSRREPGDDARRRLDGLREQYACDVRV
TH_4458|M.thermoresistible__bu      GRPENVLPTVRSLDNAALREHRVVPAAADDANAAAVVGCGPAAYGEEIVI
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      HSSTAAELQRKWLRGGAFEPDRHPALVVFPHAGGGATFYRSWLTNPDFSV
MAV_1763|M.avium_104                IAADVADAHHVARLLGAVRAELPPVAGIVHAAGEIGTTPLSDLEDAEIDR
MSMEG_0408|M.smegmatis_MC2_155      ITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAEVDR
TH_4458|M.thermoresistible__bu      VDPATRREFPPDVVGEIWVAGENVAQGYLGKPSESAETFAAHLADSGRGP
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      HVVQYPGREDRISEQLPSSLG-----------------------------
MAV_1763|M.avium_104                VFAGKVWGAWHLSEAAADLR--LDFFVSTSSIASVWGGLGQTAYGAANAF
MSMEG_0408|M.smegmatis_MC2_155      VFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAANAF
TH_4458|M.thermoresistible__bu      FLRTGDYGFLLDGELFVTGRLKDLIIIRGRNYHPNDIEATVQEVHPALMS
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      -------ALADGVAEALLTVGDRPLYLFGHSMGALVAFEVARRLETADRF
MAV_1763|M.avium_104                LDGLAWRLREQGVNGISVNFGPWAAGMADENARARLAQRGIKTLSPADAL
MSMEG_0408|M.smegmatis_MC2_155      LDGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPAEAL
TH_4458|M.thermoresistible__bu      GRGAAFAVSPDPSGTEQLVIVQEVDRGRLGEVDTDELIAAIRTAVTSQHD
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      RQLRLCVSSYTAPHLVRSRGLRDMDDEAFVAYGRSATGEVSAATGEASA-
MAV_1763|M.avium_104                AGLADVMATAAAQGVVARIDWTRFLPLYQQAGQRSLLAELAREIPDFAP-
MSMEG_0408|M.smegmatis_MC2_155      AGMADVVAG-PVQGVVAKIDWSRFLPLYQQAGRRAFLSELESELPAAATG
TH_4458|M.thermoresistible__bu      IGVHTVVLVDPLRIPTTSSGKIRRRTCRQRFLDGELDAFAEWRLATPRPA
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------FDVTALRDLVVAGLRADFHLVEQYRAEPKPPVDAPILALWGD
MAV_1763|M.avium_104                ---APTPSGKTGLVERLAGAPVQQRRKLMTEFLRNAVAEVTRVDAAEIRE
MSMEG_0408|M.smegmatis_MC2_155      AAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDADEIRD
TH_4458|M.thermoresistible__bu      QPVPAADEQADEQAG--AGPGAGPGADEIRAWFVAQLAGELGLSPDDIDT
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      DEAIDPADMDLWADVTRGGYRSA------------TFPGGHFYLAAER--
MAV_1763|M.avium_104                DAGFFDLGMDSLMAIELRRHIEQGVGKQIPATLAMDYPRLSDVAEYLL--
MSMEG_0408|M.smegmatis_MC2_155      EAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAADYLL--
TH_4458|M.thermoresistible__bu      GQPFAYYGLDSVRAIQLMTALEAWSGIKVAPTLAYDHPTIDLAAEHLAGL
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          ------------MTSGTRDSTSDSPQDSLPDNAIAVIGMAGRFPGAQSVS
Mvan_3123|M.vanbaalenii_PYR-1       ------------MTSGASNNT-----DELPDNAIAVIGMAGRFPGAGSVS
Rv2935|M.tuberculosis_H37Rv         --------------------------MSIPENAIAVVGMAGRFPGAKDVS
Mb2960|M.bovis_AF2122/97            --------------------------MSIPENAIAVVGMAGRFPGAKDVS
MLBr_02353|M.leprae_Br4923          --------------------------MITPDNAIAVVGMAGKFPGANDVS
MMAR_1772|M.marinum_M               -------------------------MSTIPDNAIAVVGMAGKFPGAKDVS
MUL_2015|M.ulcerans_Agy99           -------------------------MSTIPDNAIAVVGMAGKFPGAKDVS
MAB_2256|M.abscessus_ATCC_1997      ---DAVLETVRQWWAELDGESEASEVHEVRDDDVAVIGIAARVPGAASLD
MAV_1763|M.avium_104                ---GDVLDLRGQPDAKPAPPAGTPAPAGRTDEPIAIVAMACRFPGAADPE
MSMEG_0408|M.smegmatis_MC2_155      ---VEVLGLGEQTNVRQAS-----TVTARTDDPIAVVAVSCRFPGAPDPE
TH_4458|M.thermoresistible__bu      THTATSTAADAGVSTGAGRRPEHGPAPDRADEPIAIIGIGCRFPGADGPA
                                                                  :: :*::.:. :.*** .  

Mflv_3390|M.gilvum_PYR-GCK          EFWRNLRGGVESIVDLSESELLAAGVTEQTLANR--SYVRRAALMSGIEE
Mvan_3123|M.vanbaalenii_PYR-1       EFWRNLRNGVESIVDLPEDELLANGVTERTLSNR--SYVRRAGLMPGIDE
Rv2935|M.tuberculosis_H37Rv         AFWSNLRRGKESIVTLSEQELRDAGVSDKTLADP--AYVRRAPLLDGIDE
Mb2960|M.bovis_AF2122/97            AFWSNLRRGKESIVTLSEQELRDAGVSDKTLADP--AYVRRAPLLDGIDE
MLBr_02353|M.leprae_Br4923          AFWTNLRRGKESIVTLSEQELRDNGVSDKALADP--AYVRRAPLLDGIDE
MMAR_1772|M.marinum_M               TFWSNLRRGKESIVTLSEEELREAGVSDKTLADP--SYVRRAPLVDGIDE
MUL_2015|M.ulcerans_Agy99           TFWSNLRRGKESIVTLSEEELREAGVSDKTLADP--SYVRRAPLVDGIDE
MAB_2256|M.abscessus_ATCC_1997      EFWTNLCAGEESLTRFTDEELLSAGVTPEELRDP--RLVRVRPILADVAD
MAV_1763|M.avium_104                AFWELLSGGVDAIREVPEDRFDIDEFYDPDPETPGKMYSRFGGYLDQIDE
MSMEG_0408|M.smegmatis_MC2_155      SFWELLAGGVDAIREVPEDRWDIDEFYDPDPDTPGKTYTRFGGFLDGIDG
TH_4458|M.thermoresistible__bu      AYWRLLREGRDAITATPPERWDTDSVGDG---------TRWGGFLERIDG
                                     :*  *  * :::   . ..     .             *    :  :  

Mflv_3390|M.gilvum_PYR-GCK          FDADFFGFTPQAAKALDPQHRLFLQTVFHAFEDAGYDPKGLEATVGVFGT
Mvan_3123|M.vanbaalenii_PYR-1       FDADFFGFTPYAARMLDPQHRLFLQTVFHAMEDAGYDPKGLEATVGVFGT
Rv2935|M.tuberculosis_H37Rv         FDAGFFGFPPLAAQVLDPQHRLFLQCAWHALEDAGADPARFDGSIGVYGT
Mb2960|M.bovis_AF2122/97            FDAGFFGFPPLAAQVLDPQHRLFLQCAWHALEDAGADPARFDGSIGVYGT
MLBr_02353|M.leprae_Br4923          FDADFFGLPPLAAQVLDPQHRLFLQCAWHALEDAGCDPAQFDGSIGVYGT
MMAR_1772|M.marinum_M               FDADFFGFPPLAAQVLDPQHRLFLQCAWHALEDANCDPAKFDGSIGVYGT
MUL_2015|M.ulcerans_Agy99           FDADFFGFPPLAAQVLDPQHRLFLQCAWHALEDANCDPAKFDGSIGVYGT
MAB_2256|M.abscessus_ATCC_1997      FDTKFFGYAPSEARSIDPQQRLFLECAWEAVESAGYDLQRYDGSVGVFGG
MAV_1763|M.avium_104                FDPEFFGISPREAVWIDPQQRLVLETVWEGLERAGYSPAALRGSRSGIFV
MSMEG_0408|M.smegmatis_MC2_155      FDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRGSRTGVFT
TH_4458|M.thermoresistible__bu      FDAGFFGISPREAVRIDPQQRLLLEVAWEALEDAGLVPDRLAGSRTGVFT
                                    **. *** .*  *  ::**:**.*: .:...* *.       .:      

Mflv_3390|M.gilvum_PYR-GCK          SSTSGYLLHNLMSNYDPMMVIGQGASFDMVSLSLSNDKDHLATRVAHSYD
Mvan_3123|M.vanbaalenii_PYR-1       SSSSGYLLHNLMSNFDPMMVIGQGASFEMVNLSLQNDKDHLATRAAHQFD
Rv2935|M.tuberculosis_H37Rv         SSPSGYLLHNLLSHRDPNAVLAEGLNFDQFSLFLQNDKDFLATRISHAFN
Mb2960|M.bovis_AF2122/97            SSPSGYLLHNLLSHRDPNAVLAEGLNFDQFSLFLQNDKDFLATRISHAFN
MLBr_02353|M.leprae_Br4923          SSPSGYLLHNLLSHRDPHTVLAEGLNFDQFSLFLQNDKDFLATRISHAFN
MMAR_1772|M.marinum_M               SSPSGYLLHNLLSHRDPNTVLAEGLNFDQFSLFLQNDKDFLATRISHAFN
MUL_2015|M.ulcerans_Agy99           SSPSGYLLHNLLSHRDPNTVLAEGLNFDQFSLFLQNDKDFLATRISHAFN
MAB_2256|M.abscessus_ATCC_1997      SAGSTYYRAVLSTDYG------NLNGTEYLQTALATENDFLAPRVSYKLN
MAV_1763|M.avium_104                GVGANEYSHLLS---------AESVDKIEPHFITGNALNAISGRVAFALG
MSMEG_0408|M.smegmatis_MC2_155      GVAANEYAHLLS---------AESIDKIEPHFITGNALNAISGRVAFALG
TH_4458|M.thermoresistible__bu      GVSTYDYLHLQLS----------HPELIDAYSGTGTASSIAANRLSYVFD
                                    .  :                               .  .  : * :.  .

Mflv_3390|M.gilvum_PYR-GCK          LRGPALSVATACSSSLVAVHLACQSILNGECDIALAGGSSLRIPNRVGYW
Mvan_3123|M.vanbaalenii_PYR-1       FRGPALSVATACSSSLVAVHLACQSLLNGECDIALAGGSSLRIPHHVGYW
Rv2935|M.tuberculosis_H37Rv         LRGPSIAVQTACSSSLVAVHLACLSLLSGECDMALAGGSSLCIPHRVGYF
Mb2960|M.bovis_AF2122/97            LRGPSIAVQTACSSSLVAVHLACLSLLSGECDMALAGGSSLCIPHRVGYF
MLBr_02353|M.leprae_Br4923          LRGPSIAVQTACSSSLVALHLACLSLLSGECDMALAGGSSLCIPHRVGYW
MMAR_1772|M.marinum_M               LRGPSIAVQTACSSSLVAVHLACLSLLSGECDVALAGGSSLCVPHHVGYF
MUL_2015|M.ulcerans_Agy99           LRGPSIAVQTACSSSLVAVHLACLSLLSGECDVALAGGSSLCVPHHVGYF
MAB_2256|M.abscessus_ATCC_1997      LRGPSISLGTGCSTSLVAIHLAVQSVLTGESDMALAGGASITFPQTAGYV
MAV_1763|M.avium_104                LEGPAVAVDTACSSSLVAVHQACQALHSGDCDLALAGGVNVLLSPVSNIA
MSMEG_0408|M.smegmatis_MC2_155      FEGPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVA
TH_4458|M.thermoresistible__bu      FRGPSLTLDSACSSSLVAVHQACRSLRDGECDLALAGGVNIMLSAGIGLN
                                    :.**:::: :.**::***:* *  ::  *:.*:***** .: ..      

Mflv_3390|M.gilvum_PYR-GCK          YAQGSMVTPTGQCRPFDVRADGTVFGSGVGVLVLKALEDAVADGDRIHAV
Mvan_3123|M.vanbaalenii_PYR-1       YEQGAMVSPTGQCRPFDVRSDGTIFASGVGVVVLKALADAIDDGDHIHAV
Rv2935|M.tuberculosis_H37Rv         TSPGSMVSAVGHCRPFDVRADGTVFGSGVGLVVLKPLAAAIDAGDRIHAV
Mb2960|M.bovis_AF2122/97            TSPGSMVSAVGHCRPFDVRADGTVFGSGVGLVVLKPLAAAIDAGDRIHAV
MLBr_02353|M.leprae_Br4923          HSPGSMVSAVGHCRPFDVRADGTVFGSGVALVALKPLQAAIDASDRIHAV
MMAR_1772|M.marinum_M               TSPGSMVSAVGHCRPFDVRSDGTVFGSGVAMVVLKPLQAAIDAGDRIHAV
MUL_2015|M.ulcerans_Agy99           TSPGSMVSAVGHCRPFDVRSDGTVFGSGAAMVVLKPLQAAIDAGDRIHAV
MAB_2256|M.abscessus_ATCC_1997      ATESGAISTSGRCRAFDASADGTLVGDGIGIVLLKRASNAVADGDSILGI
MAV_1763|M.avium_104                ASRARMLSPVGRCKTFDATADGYVRSEGCGILVLKRMSDAVRDGDRVCAV
MSMEG_0408|M.smegmatis_MC2_155      ASRARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAV
TH_4458|M.thermoresistible__bu      FTRAGVMATDGRCKTFDARADGWVRGEGAGIVVLKPLREALADEDPIYAV
                                       .  ::. *:*:.**. :** : ..* .:: **    *:   * : .:

Mflv_3390|M.gilvum_PYR-GCK          IRGSALNNDGATKMTYAAPNALGQAEVIAEAHAIAGVDASTITYVETHGT
Mvan_3123|M.vanbaalenii_PYR-1       IRGSALNNDGSTKMTYAAPNALGQAEVIAEAHAIAGVDASSITYVETHGT
Rv2935|M.tuberculosis_H37Rv         IRGSAINNDGSAKMGYAAPNPAAQADVIAEAHAVSGIDSSTVSYVECHGT
Mb2960|M.bovis_AF2122/97            IRGSAINNDGSAKMGYAAPNPAAQADVIAEAHAVSGIDSSTVSYVECHGT
MLBr_02353|M.leprae_Br4923          ILGSAINNDGSMKMGYAAPNPAAQADVIAEAHAVAGIDSSTVSYVETHGT
MMAR_1772|M.marinum_M               IRGSAINNDGSAKMGYAAPNPAAQADVIAEAHAVSGIDASTVSYVECHGT
MUL_2015|M.ulcerans_Agy99           IRASAINNDGSAKMGYAAPNPAAQADVIAEAHAVSGIDASTVSYVECHGT
MAB_2256|M.abscessus_ATCC_1997      IRGTAVNNDGGNKAGFAAPSISGQVEVITEALAVAEVPAQTVDYVETHGT
MAV_1763|M.avium_104                IPASAVNQDGAS-SGLTVPNGGAQQRLIATALSRAGLSGDDVDYLEAHGT
MSMEG_0408|M.smegmatis_MC2_155      IPASSVNQDGAS-SGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGT
TH_4458|M.thermoresistible__bu      IRGSAVNQDGRT-NGLMAPSRTAQEVVLTDAYRRAGVSPGVVQYVEAQGI
                                    * .:::*:**       .*.  .*  ::  :   : :    : *:* :* 

Mflv_3390|M.gilvum_PYR-GCK          GTPLGDPIEVEGLRQAFELAEDERSAPCYLGSVKSNIGHLETAAGIAGLI
Mvan_3123|M.vanbaalenii_PYR-1       GTPLGDPIEIEGLRQAFELSEETRSAPCYLGSVKSNIGHLETAAGIAGLI
Rv2935|M.tuberculosis_H37Rv         GTPLGDPIEIQGLRAAFEVSQTSRSAPCVLGSVKSNIGHLEVAAGIAGLI
Mb2960|M.bovis_AF2122/97            GTPLGDPIEIQGLRAAFEVSQTSRSAPCVLGSVKSNIGHLEVAAGIAGLI
MLBr_02353|M.leprae_Br4923          GTPLGDPIEIQGLKTAFEVSQIPRPGPCVLGSVKSNIGHLEVAAGIAGLI
MMAR_1772|M.marinum_M               GTPLGDPIEIQGLRTAFEASETTRTGPCVLGSVKSNIGHLEVAAGIAGLI
MUL_2015|M.ulcerans_Agy99           GTPLGDPIEIQGLRTAFEASETTRTGPCVLGSVKSNIGHLEVAAGIAGLI
MAB_2256|M.abscessus_ATCC_1997      GTPLGDPIEIAALHKAFREAGDTRTQACRLGTLKPNIGHTGPASGVLALI
MAV_1763|M.avium_104                GTALGDPIEVQAAGAVYGATRDTDR-PLLIGSVKTNIGHLEAASGVAGLI
MSMEG_0408|M.smegmatis_MC2_155      GTPLGDPIEVQAAAAAYGAGRDADR-PLLMGSVKTNIGHTESASGAAGLI
TH_4458|M.thermoresistible__bu      GTPVGDAIEVGALGTVLAEDRPPDS-PCLIGSVKTNIGHLEAAAGIAGLI
                                    **.:**.**: .   .          .  :*::*.****   *:*  .**

Mflv_3390|M.gilvum_PYR-GCK          KAILCLEHKAIPATLHYTSPNPELHLDRGPFRVRAQDGPWESDG--IRRA
Mvan_3123|M.vanbaalenii_PYR-1       KAILCLEHKAIPATLHYTSPNPELHLDRGPFRIRSSDGPWESDG--IRRA
Rv2935|M.tuberculosis_H37Rv         KTILCLKNKALPATLHYTSPNPELRLDQSPFVVQSKYGPWECDG--VRRA
Mb2960|M.bovis_AF2122/97            KTILCLKNKALPATLHYTSPNPELRLDQSPFVVQSKYGPWECDG--VRRA
MLBr_02353|M.leprae_Br4923          KTILCLKNKAIPATLHYTSPNRELRLDQTPFVVQSNYGPWKWDG--VRRA
MMAR_1772|M.marinum_M               KTILCLKNRAIPATLHYTSPNPELRLEQSPFVVQNKYGPWEWDG--VLRA
MUL_2015|M.ulcerans_Agy99           KTILCLKNRAIPATLHYTSPNPELRLEQSPFVVQNKYGPWEWDG--VLRA
MAB_2256|M.abscessus_ATCC_1997      KVLLAFQHRMYPPAANFTAPNPQIEFSKSPFYVGTRLRRWNAPGGKPRRA
MAV_1763|M.avium_104                KVVLSLQHEMLPQSLHFETPSPHIPWDSLPLRVVDKAVPWQTNG-RPRRA
MSMEG_0408|M.smegmatis_MC2_155      KVVLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQTNG-RVRRA
TH_4458|M.thermoresistible__bu      KVALALRHRMIPPTLNFTEPNPTIEFDKLPVRVAQTLTPWPDDS-GRAVA
                                    *. *.:.:   * : ::  *.  :  .  *. :      *   .     *

Mflv_3390|M.gilvum_PYR-GCK          GVSSFGVGGTNAHIILEEAP-----------VAPARAQTSSPARPSVLVL
Mvan_3123|M.vanbaalenii_PYR-1       GVSSFGVGGTNAHIVLEEAP-----------TAPVPAPRSG---PQVLVL
Rv2935|M.tuberculosis_H37Rv         GVSSFGVGGTNAHVVLEEAPA----------EASEVSAHAEPAGPQVILL
Mb2960|M.bovis_AF2122/97            GVSSFGVGGTNAHVVLEEAPA----------EASEVSAHAEPAGPQVILL
MLBr_02353|M.leprae_Br4923          GVSSFGVGGTNVHVVLEEASV----------EASTVAAS---TGPQVILL
MMAR_1772|M.marinum_M               GVSSFGVGGTNAHVVLEEAP--------------TVPAHDEPAGPQVLLL
MUL_2015|M.ulcerans_Agy99           GVSSFGVGGTNAHVVLEEAP--------------TVPAHDEPAGPQVLLL
MAB_2256|M.abscessus_ATCC_1997      GVSSYSMGGTNAHAVLQEPP-------------RAELPPKSQEGAHLLVL
MAV_1763|M.avium_104                GVSSFGFTGTNAHVLIEEAPQPVTTQDAT---PAAESDARPVD---VLPL
MSMEG_0408|M.smegmatis_MC2_155      GVSSFGFTGTNAHVLVEEAPPQLHTADAAPVEPAATAEAGTDDSPQVLAL
TH_4458|M.thermoresistible__bu      GVSAFGFGGTNAHVVLAEAPQVR---------AAATADDHADGFVEILPL
                                    ***::.. ***.* :: *..                          :: *

Mflv_3390|M.gilvum_PYR-GCK          SARTQEALEDSRATLARELGENAEISLPDVAYTLGR-RRKEPIRLAAVVR
Mvan_3123|M.vanbaalenii_PYR-1       SARTEETLAQSRAALAAELSEVDEISLPDAAYTLTH-RRKDPVRLAAVVH
Rv2935|M.tuberculosis_H37Rv         SAQTAAALGESRTALAAALETQDGPRLSDVAYTLAR-RRKHNVTMAAVVH
Mb2960|M.bovis_AF2122/97            SAQTAAALGESRTALAAALETQDGPRLSDVAYTLAR-RRKHNVTMAAVVH
MLBr_02353|M.leprae_Br4923          SAQTAAALGESREALATVLEKPGAPDLSDVAYTLAG-RRKHNITMAAVVR
MMAR_1772|M.marinum_M               SAQTAAALTESRTALAEVLERSDSPDLSDVAYTLSR-RRKHNVTMAAVVS
MUL_2015|M.ulcerans_Agy99           SAQTAAALTESRTALAEVLGRSDSPDLSDVAYTLSR-RRKHNVTMAAVVS
MAB_2256|M.abscessus_ATCC_1997      SARTAPALEAARKNLAHHLARHPEQDLAAVAATLRLGRRAFSHRFAAVCA
MAV_1763|M.avium_104                SARSPEALLALAQRYGEWLHAHPDADIGDLCFTVGAGRAHFEHRAALVVD
MSMEG_0408|M.smegmatis_MC2_155      SARSPEALVELARRYDDWLSATPGLDIADVCHTAGVGRSHFEYRAALVVD
TH_4458|M.thermoresistible__bu      SARSQAALDALAERYESALTG--GVPPADLCHTAGARRAHHDHRLAVVGA
                                    **::  :*          *           . *    *       * *  

Mflv_3390|M.gilvum_PYR-GCK          DQANAATVLSAAETDGATDNVFIGR--------GHPDWDSSATDRIAFLF
Mvan_3123|M.vanbaalenii_PYR-1       DQENAATVLSAAETD----NVFIGR--------AVPDLQDSA-ERVAFLF
Rv2935|M.tuberculosis_H37Rv         DREHAATVLRAAEHD----NVFVGEAAHDGEHGDRADAAPT-SDRVVFLF
Mb2960|M.bovis_AF2122/97            DREHAATVLRAAEHD----NVFVGEAAHDGEHGDRADAAPT-SDRVVFLF
MLBr_02353|M.leprae_Br4923          DREHAVTVLRAAEHD----NVFVGESGADTGRSAAASITTLGSDRVVFLF
MMAR_1772|M.marinum_M               DREEAATALRAADND----SIFVGESVAG-----VADATAAAAERVVFLF
MUL_2015|M.ulcerans_Agy99           DREEAATALRAADND----SIFVGESVAG-----VADATAAAAERVVFLF
MAB_2256|M.abscessus_ATCC_1997      DRPEALQVLEGTGHAP-----------------FRTGTAADKPRPVVFLF
MAV_1763|M.avium_104                SVRSAREALADLADNR--------------TRPGVARGECTDPPTTAWLF
MSMEG_0408|M.smegmatis_MC2_155      SVERAREGLAALAEGR--------------TPAGVVRGEHVHRPTTAWLF
TH_4458|M.thermoresistible__bu      SRAELIGALAAYRRGE------------PHPGVFTGRSQSGHRSGVVFVF
                                    .       *                                     .::*

Mflv_3390|M.gilvum_PYR-GCK          PGQGAQHIGMARGLHDNEPVFARYFDECATAFSDEMG-FDLRAEIFDG--
Mvan_3123|M.vanbaalenii_PYR-1       PGQGAQHVGMARGLYDNEPVFKRHFDECATAFSDDMG-YDLRAEIFDG--
Rv2935|M.tuberculosis_H37Rv         PGQGAQHVGMAKGLYDTEPVFAQHFDTCAAGFRDETG-IDLHAEVFDG--
Mb2960|M.bovis_AF2122/97            PGQGAQHVGMAKGLYDTEPVFAQHFDTCAAGFRDETG-IDLHAEVFDG--
MLBr_02353|M.leprae_Br4923          PGQGAQHVGMAKGLYDTESVFAEHFDTCSAGFREAMDDLDLHSAIFNG--
MMAR_1772|M.marinum_M               PGQGAQHVGMAKGLYETEPVFAEHFDACAAGFRAEMG-VDLNAEIFNG--
MUL_2015|M.ulcerans_Agy99           PGQGAQHVGMAKGLYETEPVFAEHFDACAAGFRAEMG-VDLNAEIFNG--
MAB_2256|M.abscessus_ATCC_1997      PGQGSQFSGMGEQLYTTSSMYRRHIDECATLFEPLIG-VDLRTMLCAEGD
MAV_1763|M.avium_104                TGQGSQYPGMARELFDAEPVFAETVTRCADAVDGLLP-RPLTEVIFATDK
MSMEG_0408|M.smegmatis_MC2_155      TGQGSQYPGMARELFDTQPVFAQTVRQCAEAVADMLP-RPLLDVLFATDR
TH_4458|M.thermoresistible__bu      SDEGSQWRGMAQRLYAEDQVFRTALAECDRALRRHMEISPLSELLADP--
                                    ..:*:*  **.. *.  . ::   .  *   .        *   :     

Mflv_3390|M.gilvum_PYR-GCK          -----VGRNLEHTDRAQPALFTVEYALARLIQSYGVEPAIMAGHSIGEYP
Mvan_3123|M.vanbaalenii_PYR-1       -----VGRNLEHTDRAQPALFTVEYALAKLVQSYGVEPAIMAGHSIGEYP
Rv2935|M.tuberculosis_H37Rv         -----TATDLERIDRSQPALFTVEYALAKLVDTFGVRAGAYIGYSTGEYI
Mb2960|M.bovis_AF2122/97            -----TATDLERIDRSQPALFTVEYALAKLVDTFGVRAGAYIGYSTGEYI
MLBr_02353|M.leprae_Br4923          -----TAIDLERIDRSQPALFTVEYALAKLVESFGVGAGAYIGYSTGEYI
MMAR_1772|M.marinum_M               -----TATDLERIDRSQPALFTVEYALAKLVDTYGVRAGAYIGYSTGEYI
MUL_2015|M.ulcerans_Agy99           -----TGTDLERIDRSQPALFTVEYALAKLVDTYGVRAGAYIGYSTGEYI
MAB_2256|M.abscessus_ATCC_1997      EA---TDAALMQTRLTQPALFTVGYALSQLLGAWGVQPVAMLGHSIGELV
MAV_1763|M.avium_104                DTGGEAGKTLRNTAFAQPALFAVEMGLARLWQSWGVEPDVVLGHSVGQYA
MSMEG_0408|M.smegmatis_MC2_155      ET----ADLLQHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYA
TH_4458|M.thermoresistible__bu      -----SHSRMDEVTIASPALFAVQVALAALWQSWGVEPAAVIGHRMGEVA
                                             : .   :.****:*  .*: *  ::.: .    *:  *:  

Mflv_3390|M.gilvum_PYR-GCK          AATLAGVFDLDTAVKVVATRAKLMHAAPRG-VMIAVPLSPDAVAEYLTP-
Mvan_3123|M.vanbaalenii_PYR-1       AATIAGVFDLDTAVKVVSKRAKLMHAAPRG-VMVAVPLSPEAVAEHLTP-
Rv2935|M.tuberculosis_H37Rv         AATLAGVFDLQTAIKTVSLRARLMHESPPG-AMVAVALGPDDVTQYLPP-
Mb2960|M.bovis_AF2122/97            AATLAGVFDLQTAIKTVSLRARLMHESPPG-AMVAVALGPDDVTQYLPP-
MLBr_02353|M.leprae_Br4923          AATLAGVFDLETAIKTVSLRARLMHESPPG-AMVAVALGPEDITEYLAEY
MMAR_1772|M.marinum_M               AATLAGVFDLETAIKTVSLRARLMHESPPG-AMVAVAVGPDEIAQYLGD-
MUL_2015|M.ulcerans_Agy99           AATLAGVFDLETAIKTVSLRARLMHESPPG-AMVAVAVGPDDFAQYLGD-
MAB_2256|M.abscessus_ATCC_1997      AACAAGVFTIEEAVQLAARRGDLIQQCPSG-AMAAVGGSLEVVSALLPEG
MAV_1763|M.avium_104                AACVAGVFSLEDGARLMAERGRLFGGLPDGGRMVAVFADAQYVEELANDC
MSMEG_0408|M.smegmatis_MC2_155      AACVAGVFSLDDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEF
TH_4458|M.thermoresistible__bu      AAHVAGVLGLDDAAALLCGRTRLSRLASTG--------------------
                                    **  ***: :: .    . *  :    . *                    

Mflv_3390|M.gilvum_PYR-GCK          ---DVDIATINDPGSCVVAGTDEAIRAFQAGLAEKGVAARRVRTAHAFHS
Mvan_3123|M.vanbaalenii_PYR-1       ---DVDVATINDPGSCVVAGSEEAIRTFQAALAEKGVAARRVRTSHAFHS
Rv2935|M.tuberculosis_H37Rv         ---EVELSAVNDPGNCVVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHT
Mb2960|M.bovis_AF2122/97            ---EVELSAVNDPGNCVVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHT
MLBr_02353|M.leprae_Br4923          SAKGVELSAVNDPGNCVVAGPKDQIRAFSQRLDEVGIPVRRVRATHAFHT
MMAR_1772|M.marinum_M               ---GVELSAVNDPGNCVVAGPKDEIRAFSQRLNEAGIPVRRVRATHAFHS
MUL_2015|M.ulcerans_Agy99           ---GVELSAVNDPGNCVVAGPKDEIRAFSQRLNEAGIPVRRVRATHAFHS
MAB_2256|M.abscessus_ATCC_1997      ----VSVAAVNGPEQIVVAGREEGIEALLSTGANVGVRCTRLPVNRGFHS
MAV_1763|M.avium_104                P--RVSVAAYNGP-NTVLSGPGADLEQIVARGASDGIRCSWLETSHAFHS
MSMEG_0408|M.smegmatis_MC2_155      P--RVSVGAYNGP-NTVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHS
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          RLMDPVVAEFTAFLSGLTLREPQIPLLSNVTGTTMSASEATNPSTWARQI
Mvan_3123|M.vanbaalenii_PYR-1       RLMDPVVAEFGAFLSGVTLREPQIPLLSNITGTTMTAAEATNPSTWARQI
Rv2935|M.tuberculosis_H37Rv         SAMDPMLGQFQEFLSRQQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQI
Mb2960|M.bovis_AF2122/97            SAMDPMLGQFQEFLSRQQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQI
MLBr_02353|M.leprae_Br4923          SSMEPMLREFSEFLSRQQLRVPNTPLLSNLTGTWMSEQQVTDPENWTRQI
MMAR_1772|M.marinum_M               SSMEPMLGEFQEFLSRQQLRAPQTPLLSNLTGTWLSEQQVTDPATWARQI
MUL_2015|M.ulcerans_Agy99           SSMEPMLGEFQEFLSRQQLRAPQTPLLSNLTGTWLSEQQVTDPATWARQI
MAB_2256|M.abscessus_ATCC_1997      ALVDPAVSSFSAAVARMRLQQPQVPFISNVTGTWITGAQATEPEYWGRQL
MAV_1763|M.avium_104                ELLDPVLDEFESYAAHLDFAVPTLPLVCNRTGTVLTTETPLDARYWRRHS
MSMEG_0408|M.smegmatis_MC2_155      ELLDPVLDEFEAYAAQFQFAAPTLPLVCNRTGAVLTGQTPLDAQYWRRHS
TH_4458|M.thermoresistible__bu      ----AVREGLDGLLANLRPDDPRIPLYSTVTGDAVTG-RGFGAAHWMENL
                                        .    :    :      *  *: .. **  ::      .  * .: 

Mflv_3390|M.gilvum_PYR-GCK          RATVRFADELDALLAA-PDRVLVEVGPGGTLTSSAGRHPRWSERHRAVRL
Mvan_3123|M.vanbaalenii_PYR-1       RATVRFADELDALLAA-PDRVLVEVGPGGTLTSSAGRHPKWTERHRAVRL
Rv2935|M.tuberculosis_H37Rv         SSPIRFADELDVVLAA-PSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRL
Mb2960|M.bovis_AF2122/97            SSPIRFADELDVVLAA-PSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRL
MLBr_02353|M.leprae_Br4923          SSTIRFADELDVVLSQ-SGRVLVEVGPGGSLTGSAMRHPRWSSGHRAVRL
MMAR_1772|M.marinum_M               SSTVRFADELDVVLSQ-PNRILVEIGPGGSLTGSAIRHPKWSDGHRSVRL
MUL_2015|M.ulcerans_Agy99           SSTVRFADELDVVLSQ-PNRILVEIGPGGSLTGSAIRHPKWSDGHRSVRL
MAB_2256|M.abscessus_ATCC_1997      RETVQFARGLTTLCAEYPDALLVEVGPGHTLRGIVAAN---TPASEVVSM
MAV_1763|M.avium_104                RQPVQFAESVRTVAAL-GCTVLMEIGPQPVLTG--AAVQVWPEHLAAPRA
MSMEG_0408|M.smegmatis_MC2_155      RQPVQFAESVRTVAAL-GCSVLMEIGPQPVLTG--AAVQVWPEHMAAPRA
TH_4458|M.thermoresistible__bu      HSPVRFSAAVRRLLGR-GHDAFLEISAHPMLLS--AVQEDAADLGRSCTT
                                      .::*:  :  : .      ::*:..   * .        .        

Mflv_3390|M.gilvum_PYR-GCK          MRHQAQNRSDDDTFHLALGQLWAADVDVDWTQGDQDAADARTLVTLPGYP
Mvan_3123|M.vanbaalenii_PYR-1       MRHQAQNRNDHDTFLLALGQLWAADVEVDFNQG---AEEDRTLITLPGYP
Rv2935|M.tuberculosis_H37Rv         MRHPLQDVDDRDTFLRALGELWSAGVEVDWTPR---RPAVPHLVSLPGYP
Mb2960|M.bovis_AF2122/97            MRHPLQDVDDRDTFLRALGELWSAGVEVDWTPR---RPAVPHLVSLPGYP
MLBr_02353|M.leprae_Br4923          MRHPLQNVDDHDTFLRALGELWSAGIEVDWAPQ---RSVMPHLVSLPGYP
MMAR_1772|M.marinum_M               MRHPIQNLDDRETFLRALGELWSAGVDVDWTPR---RAASPRIVSLPGYP
MUL_2015|M.ulcerans_Agy99           MRHPIQNLDDRETFLRALGELWSAGVDVDWTPR---RAASPRIVSLPGYP
MAB_2256|M.abscessus_ATCC_1997      LGDRTG--DSATVALAAAGRLWAGGAELAWQHFG----ASRPRVPLPTYP
MAV_1763|M.avium_104                IVSLRKGVGDRRQIAEGLAAAYVSGHRPEFAALHR---RPRRKLELPTYP
MSMEG_0408|M.smegmatis_MC2_155      VASLRKGVADRRQIADALASAYVGGHRPDFAAVHR---QPRRPVELPTYP
TH_4458|M.thermoresistible__bu      LVSMRRGECGRDVLMTSLAALYASGHAVDWARVHP---HGSHCTAAPTYP
                                    :        .      . .  : ..    :                * **

Mflv_3390|M.gilvum_PYR-GCK          FARQRHWVEYN----ASSAWVANGSGAAGVSATGAQAGSAAGGAGGGSSV
Mvan_3123|M.vanbaalenii_PYR-1       FAKQRHWVEHN----ANAAWLAGGAGADGTAAAAGSAGVAPVAAGGTSTV
Rv2935|M.tuberculosis_H37Rv         FARQRHWVEPNHTVWAQAPGANNGSPAGTADGSTA--ATVDAARNGESQT
Mb2960|M.bovis_AF2122/97            FARQRHWVEPNHTVWAQAPGANNGSPAGTADGSTA--ATVDAARNGESQT
MLBr_02353|M.leprae_Br4923          FARQRHWVEPRYTIWAQIPGASSGSPVDSSVDS----ATVEGVRGGESQT
MMAR_1772|M.marinum_M               FARQRHWVEPKHMAWAQIPTASNGSSVGAKLGSGADSGIRGGAQTGESQT
MUL_2015|M.ulcerans_Agy99           FARQRHWVEPKHMAWAQIPTASNGSSVGAKLGSGADSGIRGGAQTGESQT
MAB_2256|M.abscessus_ATCC_1997      FERERLWMSPP--------RSVLDKPVQAPIAPAVQVPLVTASTQTDVPD
MAV_1763|M.avium_104                FQRRRFWPKASGIAGIDGQGAAASGLLGSAKELASGDSVYTSRLSVKSQP
MSMEG_0408|M.smegmatis_MC2_155      FQRRRFWPKASSIA-VDG-GTAASGILGSGKDLASGDTIYTSRLSVKSQP
TH_4458|M.thermoresistible__bu      WQRQRFWLDIDR------------CDTGDGAGTGGTAERTVVPAPLPAPS
                                    : :.* * .                                         

Mflv_3390|M.gilvum_PYR-GCK          EASLQRIWAQCLGVNEIDRHANFFEIG-----------------------
Mvan_3123|M.vanbaalenii_PYR-1       EAKLARIWSQCLGLSDIDRNANFFEIG-----------------------
Rv2935|M.tuberculosis_H37Rv         EVTLQRIWSQCLGVSSVDRNANFFDLG-----------------------
Mb2960|M.bovis_AF2122/97            EVTLQRIWSQCLGVSSVDRNANFFDLG-----------------------
MLBr_02353|M.leprae_Br4923          EATLQRIWSQCLGVSSVDRNANFFDLG-----------------------
MMAR_1772|M.marinum_M               EDVLQRIWSQCLGVGSVDRNANFFDMG-----------------------
MUL_2015|M.ulcerans_Agy99           EDVLQRIWSQCLGVGSVDRNANFFDMG-----------------------
MAB_2256|M.abscessus_ATCC_1997      AAVVEQIWCEALGVPSVESDDNFFDLG-----------------------
MAV_1763|M.avium_104                WLADHVIYGTVVVPGATYAAMALAAVGPPARVQNVYFYEPIILPDKASRE
MSMEG_0408|M.smegmatis_MC2_155      WLADHVIYGTVVVPGATYAAMALAAVGTPARLKDVFFYEPIILPEKASRE
TH_4458|M.thermoresistible__bu      ASAAPTVDEVLLCADQRERRE-----------------------------
                                          :    :                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                VQLSLHPLQEG-GWSFRVDSRPYGVPDAEWSLNADGTV-VAGIEDEPAAD
MSMEG_0408|M.smegmatis_MC2_155      VQLTLHPADGGSVLSFQIHSRPYGERGADWSLNAEGTVDTAGSDPDAAAD
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                P-ADHIDAVIERLDRNRPQLLFDSFAESELEWGTTWSTSLKSLWMGDGEA
MSMEG_0408|M.smegmatis_MC2_155      EQSDPVDEVIERLERMRPQDLFETFADLELAWGPTWSGSLKSLWLGDGEA
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          -GDSLVAISVAMTAGHAGLDLTPQDLYENQTVASLAKVLTARYAEGGLAR
Mvan_3123|M.vanbaalenii_PYR-1       -GDSLIAISVAMTAGHEGLDLTPQDLYENQTVAALAKVLTARYAEGGLAR
Rv2935|M.tuberculosis_H37Rv         -GDSLMAISIAMAAANEGLTITPQDLYEYPTLASLTAAVDASFASSGLAK
Mb2960|M.bovis_AF2122/97            -GDSLMAISIAMAAANEGLTITPQDLYEYPTLASLTAAVDASFASSGLAK
MLBr_02353|M.leprae_Br4923          -GDSLMAISISMAAANEGMTITPQDMYEHPTLASLTAAVDASFASSGLAK
MMAR_1772|M.marinum_M               -GDSLMAISIAMSAANEGLTITPQDLYEHPTLASLTAAIDASFASSGLAK
MUL_2015|M.ulcerans_Agy99           -GDSLMAISIAMSAANEGLTITPQDLYEHPTLASLTAAIDASFASSGLAK
MAB_2256|M.abscessus_ATCC_1997      -GDSLIAARVVTAIGER-----------CHIKVSVAELWDQGATLADLAE
MAV_1763|M.avium_104                VGDVTVGDELAEHLGTEPMHPVLLDLCTGVVFPAFPALLAAEQGFNDLLL
MSMEG_0408|M.smegmatis_MC2_155      VGDILVGAELAEQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFL
TH_4458|M.thermoresistible__bu      LLESYLRDRVAAELGVLPPLLDVAAPLSTLGIDSLTAAELRARVERDLGI
                                      :  :   :    .                  :..          .*  

Mflv_3390|M.gilvum_PYR-GCK          QS---------------------VDDSTSPPVPPNVAYFLEHGLRDVGRW
Mvan_3123|M.vanbaalenii_PYR-1       QT---------------------LDDAVNPPVPPNVAYFLEHGLRDIGRW
Rv2935|M.tuberculosis_H37Rv         P----------------------PEAQANPAVPPNVTYFLDRGLRDTGRC
Mb2960|M.bovis_AF2122/97            P----------------------PEAQANPAVPPNVTYFLDRGLRDTGRC
MLBr_02353|M.leprae_Br4923          P----------------------PEAAAHPAVPPNIAYFLERGLCDTGRW
MMAR_1772|M.marinum_M               P----------------------PEADANPAVPPNIAYFLDRGLRDTGRW
MUL_2015|M.ulcerans_Agy99           P----------------------PEADANPAVPPNIAYFLDRGLRDTGRW
MAB_2256|M.abscessus_ATCC_1997      LV---------------------ERRAINSKVGEQLK-------------
MAV_1763|M.avium_104                PLRYGQVSLREKMPRRFYCRGKWRPSALDSETQVFDIDFIDRDGRHLGGI
MSMEG_0408|M.smegmatis_MC2_155      PLRYGQVTLAEKMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALGGI
TH_4458|M.thermoresistible__bu      VIP--------------------VAQLLNGPSVSDLAEWISTTMVGFG--
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          RIPVILGLRSDVGEDDVR--------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       RIPVILGLRSDVGEDDVR--------------------------------
Rv2935|M.tuberculosis_H37Rv         RVPLILRLDPKIGLPDIR--------------------------------
Mb2960|M.bovis_AF2122/97            RVPLILRLDPKIGLPDIR--------------------------------
MLBr_02353|M.leprae_Br4923          RVPLILRLDPKIGSDDIR--------------------------------
MMAR_1772|M.marinum_M               RVPLILRLDPQVGPEDIR--------------------------------
MUL_2015|M.ulcerans_Agy99           RVPLILRLDPQVGPEDIR--------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                REFTVKRAPREALLRGLGGDATRLLYTLGWHEVPPQPSNDGVANPSGTWL
MSMEG_0408|M.smegmatis_MC2_155      REFTVKRAPREALLRGLGGDATRLLYTLGWHEVPPPPSAD---DAVGTWL
TH_4458|M.thermoresistible__bu      --------------S-----------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                IAGFDELGAQLPGCIPFDRNTDPESFGQLLARAEDRGGPVTGIVWRATQS
MSMEG_0408|M.smegmatis_MC2_155      IAGFDELAAKVPGCVPIDRNTDLQVLGEVLSQAHARGAGFSGVVWRCATP
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                GGRES--SAESVARLETEIAGLLTAVHALQNADGSAVKLPGGLWIVTERG
MSMEG_0408|M.smegmatis_MC2_155      GRKESGSASAESARLEAEITNLLSAVHAAQ---GPSVKLPGGLWIVTEHG
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          -----------------AVLTAVTDAHDVLRVRLVERSG-----------
Mvan_3123|M.vanbaalenii_PYR-1       -----------------AVLTAVTEVHDALRVHLVERAG-----------
Rv2935|M.tuberculosis_H37Rv         -----------------AVLTAVVNHHDALRLHLVGNDG-----------
Mb2960|M.bovis_AF2122/97            -----------------AVLTAVVNHHDALRLHLVGNDG-----------
MLBr_02353|M.leprae_Br4923          -----------------AVLTAVVNHHDVLRLSLVDNDG-----------
MMAR_1772|M.marinum_M               -----------------AVLSAVTNHHDALRLRLVENGG-----------
MUL_2015|M.ulcerans_Agy99           -----------------AVLSAVTNHHDALRLRLVENGG-----------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                VATESGEPVDPVQAALWGLGRTIVNEEPALRCRLVDSDGSEQAVRSLAGL
MSMEG_0408|M.smegmatis_MC2_155      VACESGEPVDPVQAALWGFGRTTINEEPALHCRLVDCDGSSEAVDLLAAL
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                LGAP-LDEPELAVRQGKLLASRLLPWARSGHLAVPRGTDYVLAPTERGAI
MSMEG_0408|M.smegmatis_MC2_155      LAAPGIQEPEIAVRQGKLLASRLLPWARSGHLTLPRGGDFVLAPTERGAI
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                DNLRLIEQEAPPPAEGCVQVRVEAGGLNFREVLNVLGLYPGDPGPLGGDF
MSMEG_0408|M.smegmatis_MC2_155      DNLRLTETDVPEPDEGYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDF
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          ----------------------------------IWDQIIAEPGEFTELA
Mvan_3123|M.vanbaalenii_PYR-1       ----------------------------------TWDQHIAEPGEFTELV
Rv2935|M.tuberculosis_H37Rv         ----------------------------------IWEQHIAAPAEFTGLS
Mb2960|M.bovis_AF2122/97            ----------------------------------IWEQHIAAPAEFTGLS
MLBr_02353|M.leprae_Br4923          ----------------------------------MWEQHIAATGEFTRLL
MMAR_1772|M.marinum_M               ----------------------------------VWEQHIAAPADFTELA
MUL_2015|M.ulcerans_Agy99           ----------------------------------VWEQHIAAPADFTELA
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                AGTVTQLGSGVTGLEVGTRVYGFMQGAFASRFNVPVQLLAPIPDGVSAVD
MSMEG_0408|M.smegmatis_MC2_155      AGTVTQLGAGVSGLEIGQRVYGSMQGAFASRFNVPAQFLAPIPDGIGAVE
TH_4458|M.thermoresistible__bu      --------------------------------------TTPEPESAGVPG
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          SRELPSGVAAGSPQEREAVLAFLDEQVREH-QVVVPLTATLIRSGSGGPS
Mvan_3123|M.vanbaalenii_PYR-1       ARQLPEGLAAGSPQEREAVLGFLDEQVREH-QVVVPLAATFIRGVTGGPS
Rv2935|M.tuberculosis_H37Rv         NRSVPNGVAAGSPEERAAVLGILAELLEDQTDPNAPLAAVHIAAAHGGPH
Mb2960|M.bovis_AF2122/97            NRSVPDGVAAGSPEERAAVLGILAELLEDQTDPNAPLAAVHIAAAHGGPH
MLBr_02353|M.leprae_Br4923          TQTLPDGVAAGSAEERAVVSSILAELIASQSDLNEPLTAVQITTAHGGPH
MMAR_1772|M.marinum_M               TRQLPGDLAAGEADEHGAVSNIVAELIAEQGDSNAPLIAVHVTAPNGGAQ
MUL_2015|M.ulcerans_Agy99           TRQLPDDLAADEADEHSAVSNIVAELIAEQGDSNAPLIAVHVTAPNGGAQ
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                AATIPAAALTARLAFDWAQLKPGDRVLIHAASGGVGLAAIQLAQRHGATV
MSMEG_0408|M.smegmatis_MC2_155      AATIPAAALTVRLAFDWAQLKPGDKVLIHAASGGVGLAAIQMAQQSGAEV
TH_4458|M.thermoresistible__bu      RSRPPDGAVASGSGDGGRWIELLNQMPEVSDDTVDELLRQLLAAGENHDD
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          YLALSLHGIAGDVSG----DSASRDVLLTDLFTAFNQRMAGEEIVLAPVT
Mvan_3123|M.vanbaalenii_PYR-1       YLALSLHGIAG--------DDVSRDVLLTDVFTAFSQRMAGEEIVLAPVP
Rv2935|M.tuberculosis_H37Rv         YLCLAIHAMVT--------DDSSRQILATDIVTAFGQRLAGEEITLEPVS
Mb2960|M.bovis_AF2122/97            YLCLAIHAMVT--------DDSSRQILATDIVTAFGQRLAGEEITLEPVS
MLBr_02353|M.leprae_Br4923          YLGLAVHQMVI--------DDASRQILGTDIITAFGQRLAGEEITLEPVT
MMAR_1772|M.marinum_M               YLGLALHEMVA--------DDASRQLLGADIITAFAQRLGDQEIKLDPVT
MUL_2015|M.ulcerans_Agy99           YLGLALHETVA--------DDASRQLLGADIITAFAQRLDDQEIKLDPVT
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                FATASTYKRATLRKLGVEYVYDSRSTDFADQILADTDGAGVDVVLNSLTN
MSMEG_0408|M.smegmatis_MC2_155      FATASTFKRSTLRRLGVKYVYDSRTTDFADQILADTNGAGVDVVLNSLTS
TH_4458|M.thermoresistible__bu      TQLH----------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          ASWREWSQRCAGLAGHPAVLDSRDYWLQTAHRST----------------
Mvan_3123|M.vanbaalenii_PYR-1       ASWREWSQRCAGLASHPAVLDSRDYWLQTAGAST----------------
Rv2935|M.tuberculosis_H37Rv         TGWREWSLRCAALATHPAALDTRSYWIENSTKAT----------------
Mb2960|M.bovis_AF2122/97            TGWREWSLRCAALATHPAALDTRSYWIENSTKAT----------------
MLBr_02353|M.leprae_Br4923          TGWREWSLRCAALATHPAALDTRSFWIENANKVN----------------
MMAR_1772|M.marinum_M               TGWRDWSVRCAALATHPAALDTRSYWIEQSTKAN----------------
MUL_2015|M.ulcerans_Agy99           TGWRDWSVRCAALATHPAALDTRSYWIEQSTKAN----------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                EGFIEATVRATAQHGRFVEIAKRDIWTREQMAAARPDIAYEIVALDWACV
MSMEG_0408|M.smegmatis_MC2_155      AGFVEATLKATAQGGRFAEIAKRDIWSHEQMAEARPDIAYEIVALDTVMF
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------LRVAGG----EPADRPGAADLERLSTMLSAAETGEFDDARRR
Mvan_3123|M.vanbaalenii_PYR-1       --------LRIAGP----EHSERPGVDDVTRLSTALSAAETGEIDDARRR
Rv2935|M.tuberculosis_H37Rv         --------LWLADALPNAHTAHPPRADELTKLSSTLSVEQTSELDDGRRR
Mb2960|M.bovis_AF2122/97            --------LWLADALPNAHTAHPPRADELTKLSSTLSVEQTSELDDGRRR
MLBr_02353|M.leprae_Br4923          --------LWLADVSLNTDVIQPPGADDLIRMPCTLSVEQTSELDDARRR
MMAR_1772|M.marinum_M               --------LWLTDG----DAAQPPSATDLTKLPSVLNAEQTSELDDARRR
MUL_2015|M.ulcerans_Agy99           --------LWLTDG----DAAQPPSATDLTKLPSVLNAEQTSELDDARRR
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                EQPEHIHALLTEVSDGLASGEWRPLPAEIYPLAEAKTAFRRMQQARHIGK
MSMEG_0408|M.smegmatis_MC2_155      TEPDRIRDLLTEVSDGMARGEWTPLPAEIYPITEARSAFRRMQQARHIGK
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          LRLSAEEILLAALGRAVAVTVGEGAVAVDLGGRGRSVLK----------P
Mvan_3123|M.vanbaalenii_PYR-1       LRLPVEEILLAALGRAVAATVGEGAVSVDLGGRGRSVLK----------P
Rv2935|M.tuberculosis_H37Rv         FRRSIQTILLAALGRTIAQTVGEGVVAVELEGEGRSVLR----------P
Mb2960|M.bovis_AF2122/97            FRRSIQTILLAALGRTIAQTVGEGVVAVELEGEGRSVLR----------P
MLBr_02353|M.leprae_Br4923          FRRSIQAIVLAALGRTIAQTVGDGVVAVELEGEGRSVLR----------P
MMAR_1772|M.marinum_M               FRRSIQTILLAALGRTIAQTVGDGVVAVELDGEGRSVLR----------P
MUL_2015|M.ulcerans_Agy99           FRRSIQTILLAALGRTIAQTVGDGVVAVELDGEGRSVLR----------P
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                IVLQMPKPLQPRGDRSYLITGGLGAIGLHLAAYLAQLGAGEIVLTSRRAP
MSMEG_0408|M.smegmatis_MC2_155      IVLQVPKPLQPQQDRSYLITGGLGAIGLHTAAYLAQLGAGDIVLTSRRDP
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          DVDLARTVGSFAALHPVVLT-ASGQ--TASAALAEVRQTLDAVPHYGIGY
Mvan_3123|M.vanbaalenii_PYR-1       DVDLQRTVGWFTTIHPVVLT-AARQG-SATQALGDVRETLKAVPHYGIGY
Rv2935|M.tuberculosis_H37Rv         DVDLRRTVGWFTTYYPVPLACATGLG--ALAQLDAVHNTLKSVPHYGIGY
Mb2960|M.bovis_AF2122/97            DVDLRRTVGWFTTYYPVPLACATGLG--ALAQLDAVHNTLKSVPHYGIGY
MLBr_02353|M.leprae_Br4923          DVDVRRTIGWFTNYYPIPLVCVKGQG--ALAQLDAVHNTLKSIPHYGIGY
MMAR_1772|M.marinum_M               DVDVRRTVGRFTTYYPVALTCATGQGAAALKGLDAVHDTLKSVPHYGIGY
MUL_2015|M.ulcerans_Agy99           DVDVRRTVGRFTTYYPVALTCATGQGAAALKGLDAVHDTLKSVPHYGIGY
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                DAAAWRAIDDITERYRCRVHTFAADVGDAAQVEQLLARIRAELPPLAGVA
MSMEG_0408|M.smegmatis_MC2_155      DESAQRAIDEITERHKCRIHTYAADVGDEAQVADLLARIRAELPPLAGIA
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          GLLRYLYAPTARLLGDGRPADILFSHVGTIPDAPADQPDDAPVRFDPDTA
Mvan_3123|M.vanbaalenii_PYR-1       GLLRYLYAPTARVLGASRPADILFSHIGTIPEVPAEQPDDAPVRFDADTA
Rv2935|M.tuberculosis_H37Rv         GLLRYVYAPTGRVLGAQRTPDIHFRYAGVIPELPSG---DAPVQFDSDMT
Mb2960|M.bovis_AF2122/97            GLLRYVYAPTGRVLGAQRTPDIHFRYAGVIPELPSG---DAPVQFDSDMT
MLBr_02353|M.leprae_Br4923          GLLRYMYAPTGRVFSAQRTPDIHFRYVGVVPEPPSV---DATVQFDSDMT
MMAR_1772|M.marinum_M               GLLRYLYAPTGRVLGAQRTPDIHFRYAGTIPELPPV---DAPVQFDSDLA
MUL_2015|M.ulcerans_Agy99           GLLRYLYAPTGRVLGAQRTPDIHFRYAGTIPELPPV---DAPVQFDSDLA
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                HLAGVLDDALLSQQSPERFRVALAPKAFGASYLDHATRTDDLDFFIVSSS
MSMEG_0408|M.smegmatis_MC2_155      HLAGVLDDALLSAQNPERFRTTLAPKAYGASHLDRLTRDDDLDFFIVSSS
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          MPIRDALPGLGHALEVRIYRT------------GGELHLDWWYDIRRLGP
Mvan_3123|M.vanbaalenii_PYR-1       MPIRDALPGLGHAVELRVYRA------------AGVLHLDWWYDNRRLGP
Rv2935|M.tuberculosis_H37Rv         LPVREPIPGMGHAIELRVYRF------------GGSLHLDWWYDTRRIPA
Mb2960|M.bovis_AF2122/97            LPVREPIPGMGHAIELRVYRF------------GGSLHLDWWYDTRRIPA
MLBr_02353|M.leprae_Br4923          IPVQEPVPGMGHAIELRTYRF------------GGSLHLDWWYDIRRIPQ
MMAR_1772|M.marinum_M               MPVREPLPGLGHAVEIRAYRS------------GSSLHVDWWYDTRRITA
MUL_2015|M.ulcerans_Agy99           MPVREPLPGLGHAVEIRAYRS------------GSSLHVDWWYDTRRITA
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                VSSLLGSPGQANYSTANAWLDGLVAARQARGLPATGVNLGPWAQGGMASS
MSMEG_0408|M.smegmatis_MC2_155      VSSLFGSPGQANYATANAMLDGLVAKRRAQGLVATGINFGPWGQGGMASS
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          TDVESFSRQYSAAVLDISREALAEEDTDAAGDELA-------LVDLS---
Mvan_3123|M.vanbaalenii_PYR-1       TDVESFARQYSEALLDVTRDALAEEDTDAAGDELA-------LVDLS---
Rv2935|M.tuberculosis_H37Rv         ATAEALERTFPLALSALIQEAIAAEHTEHDDSEIVGEPEAGALVDLSSMD
Mb2960|M.bovis_AF2122/97            ATAEALERTFPLALSALIQEAIAAEHTEHDDSEIVGEPEAGALVDLSSMD
MLBr_02353|M.leprae_Br4923          VTAEALAQSFPVTLSKLIQEGIATQKDAHDESEMAGAPQAGVLVDLSTLD
MMAR_1772|M.marinum_M               ETATALARSFPTALSELIQESIAAEQEERDEDEKVGVIEAGALVDLSSLD
MUL_2015|M.ulcerans_Agy99           ETATALARSFPTALSELIQESIAAEQEERDEDEKVGVIEAGALVDLPSLD
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                EAARANIGAQGLIPLEPTAALAALAEVVANGTGQATVIKANWQRAAKLLG
MSMEG_0408|M.smegmatis_MC2_155      EAATANITAQGLIPLDPSAALHALAEVIANGSGQATVLKANWQRAAKVLG
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         AG------------------------------------------------
Mb2960|M.bovis_AF2122/97            AG------------------------------------------------
MLBr_02353|M.leprae_Br4923          AG------------------------------------------------
MMAR_1772|M.marinum_M               AG------------------------------------------------
MUL_2015|M.ulcerans_Agy99           AG------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                GARPPILDLVLPSAVGEASGDSELLKQLQEIPVAQRAAFITEFLQREVQG
MSMEG_0408|M.smegmatis_MC2_155      SARPPILDLVLPSAAGEATGDSELLKQLMEIPIPQRAGFVTEFLQREVQN
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                FLRLAQPPAATSRFLDLGTDSLMAVELRNRLHSQFGGAFTINATAVFDYP
MSMEG_0408|M.smegmatis_MC2_155      FLRLASPPAASSRFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYP
TH_4458|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3390|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3123|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2935|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2960|M.bovis_AF2122/97            --------------------------------------------------
MLBr_02353|M.leprae_Br4923          --------------------------------------------------
MMAR_1772|M.marinum_M               --------------------------------------------------
MUL_2015|M.ulcerans_Agy99           --------------------------------------------------
MAB_2256|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_1763|M.avium_104                TIGGLAEYLAGQLPDAESEPGAAVAANPNPGSETGTGEAEPEREAAPEPS
MSMEG_0408|M.smegmatis_MC2_155      TIGGLAEYLVGQLPDAEAPETA----------------------------
TH_4458|M.thermoresistible__bu      --------------------------------------------------