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MQHSSTAAELQRKWLRGGAFEPDRHPALVVFPHAGGGATFYRSWLTNPDFSVHVVQYPGREDRISEQLPS SLGALADGVAEALLTVGDRPLYLFGHSMGALVAFEVARRLETADRFRQLRLCVSSYTAPHLVRSRGLRDM DDEAFVAYGRSATGEVSAATGEASAFDVTALRDLVVAGLRADFHLVEQYRAEPKPPVDAPILALWGDDEA IDPADMDLWADVTRGGYRSATFPGGHFYLAAERDAVLETVRQWWAELDGESEASEVHEVRDDDVAVIGIA ARVPGAASLDEFWTNLCAGEESLTRFTDEELLSAGVTPEELRDPRLVRVRPILADVADFDTKFFGYAPSE ARSIDPQQRLFLECAWEAVESAGYDLQRYDGSVGVFGGSAGSTYYRAVLSTDYGNLNGTEYLQTALATEN DFLAPRVSYKLNLRGPSISLGTGCSTSLVAIHLAVQSVLTGESDMALAGGASITFPQTAGYVATESGAIS TSGRCRAFDASADGTLVGDGIGIVLLKRASNAVADGDSILGIIRGTAVNNDGGNKAGFAAPSISGQVEVI TEALAVAEVPAQTVDYVETHGTGTPLGDPIEIAALHKAFREAGDTRTQACRLGTLKPNIGHTGPASGVLA LIKVLLAFQHRMYPPAANFTAPNPQIEFSKSPFYVGTRLRRWNAPGGKPRRAGVSSYSMGGTNAHAVLQE PPRAELPPKSQEGAHLLVLSARTAPALEAARKNLAHHLARHPEQDLAAVAATLRLGRRAFSHRFAAVCAD RPEALQVLEGTGHAPFRTGTAADKPRPVVFLFPGQGSQFSGMGEQLYTTSSMYRRHIDECATLFEPLIGV DLRTMLCAEGDEATDAALMQTRLTQPALFTVGYALSQLLGAWGVQPVAMLGHSIGELVAACAAGVFTIEE AVQLAARRGDLIQQCPSGAMAAVGGSLEVVSALLPEGVSVAAVNGPEQIVVAGREEGIEALLSTGANVGV RCTRLPVNRGFHSALVDPAVSSFSAAVARMRLQQPQVPFISNVTGTWITGAQATEPEYWGRQLRETVQFA RGLTTLCAEYPDALLVEVGPGHTLRGIVAANTPASEVVSMLGDRTGDSATVALAAAGRLWAGGAELAWQH FGASRPRVPLPTYPFERERLWMSPPRSVLDKPVQAPIAPAVQVPLVTASTQTDVPDAAVVEQIWCEALGV PSVESDDNFFDLGGDSLIAARVVTAIGERCHIKVSVAELWDQGATLADLAELVERRAINSKVGEQLK
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_2256 | - | - | 100% (1257) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_2257 | - | 0.0 | 42.20% (929) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | e-141 | 35.07% (904) | polyketide synthase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2960 | ppsE | 0.0 | 40.33% (1019) | phenolpthiocerol synthesis type-I polyketide synthase PPSE |
M. gilvum PYR-GCK | Mflv_3390 | - | 0.0 | 40.98% (1020) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2935 | ppsE | 0.0 | 40.33% (1019) | phenolpthiocerol synthesis type-I polyketide synthase PPSE |
M. leprae Br4923 | MLBr_02353 | - | 0.0 | 39.33% (1012) | polyketide synthase |
M. marinum M | MMAR_1772 | ppsE | 0.0 | 40.30% (1010) | phenolpthiocerol synthesis type-I polyketide synthase PpsE |
M. avium 104 | MAV_3107 | - | 1e-146 | 34.87% (1001) | polyketide synthase |
M. smegmatis MC2 155 | MSMEG_0408 | - | 1e-139 | 35.12% (914) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4458 | - | 1e-116 | 33.00% (1015) | PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide |
M. ulcerans Agy99 | MUL_2015 | ppsE | 0.0 | 40.20% (1010) | phenolpthiocerol synthesis type-I polyketide synthase PpsE |
M. vanbaalenii PYR-1 | Mvan_3123 | - | 0.0 | 40.63% (1019) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 MVSAEHPIEPTPSFAIIGYAARFPGAASAEEYWALLRDGREAISDVPKDR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 WDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPFFGMSAREVRLMDPQH TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 RILMETAWRAVEHSGIAPTSLANSNTGVFVGLATHDYLGMASDELTYPEI TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 NECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 CGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 DALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAGEVLGAGRAPEEPLLI TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 GSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHLNFETPSPHIPWERLP TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 IEVVRETVPWQRNGKPRIAGVSSFGFAGTNAHVILEEAPAVGTPATTEPV TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 EDPRRYSVLPLSARTPEALVRLAGEYRDWLRAHPQARLADVSHTAGTARA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 HLEQRAALVVNSRESAIELLGALADDRPAPGLVRGESHEAPKTAWLFTGQ TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 GSQYPGMARELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDADELDGD TH_4458|M.thermoresistible__bu ------------------------------------------------LL Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 TESPLRHTTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYSAACVA TH_4458|M.thermoresistible__bu SLLRQRSERYGDKIAFDYCTGEQEHSRLTYQELDIRARAIAAHLQDQGVA Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 GVFDVEDGARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEYPSLSV TH_4458|M.thermoresistible__bu GERVLVLCPSGLDFITAMFGCFYVG------------AVAVPVHPPVHNR Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 AAYNGANTVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALLDPILD TH_4458|M.thermoresistible__bu LLSRVASIVADVRATSVLTTAATRADLKEILDGLHDGDPLRWLAVDTIEA Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 DFESFAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQPVEFAK TH_4458|M.thermoresistible__bu DDETSWTPTTVDTDSVAFVQYTSGSTSTPKG------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 SVRTLADMNCRVLLEIGPRPVLTATALAAWPDPATTPQVLASLRPTTADH TH_4458|M.thermoresistible__bu -------------------------------VVLTHHNLLANLESISRDA Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 RQITEAVAAAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFSDNRAI TH_4458|M.thermoresistible__bu GQGDEARVVSWLPLHHDMG------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 DRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTLRVLNK TH_4458|M.thermoresistible__bu ----LIGGIFGVVHFGGTAYLMPPSSFIQRPMSWLEAISWHGANISVGPN Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LAARHNQQRSTHVDPDARYEIRWDAIASAAASTGAAADWILVGDDTAAVL TH_4458|M.thermoresistible__bu FGYQLCVERSTPEERATLDLSTWVRAYCGAEPVRAATMRRFTEAFAPAGF Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 EFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAGELYVVHIAAGDG TH_4458|M.thermoresistible__bu RADAFHPVYGLAEATLFVSGRPENVLPTVRSLDNAALREHRVVPAAADDA Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 AAAPMRDLLRVQHRTLGGLRRLFRAANDAELRSPIWLVTRDGQRVTDTDT TH_4458|M.thermoresistible__bu NAAAVVG---------------------------------CGPAAYGEEI Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 VVPEQSCLWGFGRAAALELPHIWGGLADLSGADTEWPRLIARITSPRDGE TH_4458|M.thermoresistible__bu VIVDPATRREFP------------------------PDVVGEIWVAGENV Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 ----------------------------------------MQHSSTAAEL MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 DQIALRGDAVYAPRLVRRTGEPSDTPLPVREDRTYLVTGGLGAIGLEVAG TH_4458|M.thermoresistible__bu AQGYLGKPSESAETFAAHLADSGRGPFLRTGDYGFLLDG----------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 QRKWLRGGAFEPDRHPALVVFPHAGGGATFYRS----------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 YLASHGAGHVVLTSRREPGDDARRRLDGLREQYACDVRVITADVADAHDV TH_4458|M.thermoresistible__bu --------------------------ELFVTGRLKDLIIIRGRNYHPNDI Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 ----------------------------WLTNPDFSVHVVQYPGREDRIS MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 ARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAEVDRVFAGKVWGAWH TH_4458|M.thermoresistible__bu EATVQEVHPALMSGRGAAFAVSPDPSGTEQLVIVQEVDRGRLGEVDTDEL Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 EQLPSSLGALADGVAEALLTVGDRPLYLFGHSMGALVAFEVARRLETADR MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAANAFLDGLAWRLRER TH_4458|M.thermoresistible__bu IAAIRTAVTSQHDIGVHTVVLVDPLR------------------------ Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 FRQLRLCVSSYTAPHLVRSRGL---------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 GVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPAEALAGMADVVAGPV TH_4458|M.thermoresistible__bu ----------------IPTTSSGKIRRRTCRQRFLDGELDAFAEWRLATP Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 QGVVAKIDWSRFLPLYQQAGRRAFLSELESELPAAATGAAAPATVPGKPP TH_4458|M.thermoresistible__bu R-------------------------------------PAQPVPAADEQA Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -----------------------------------RDMDDEAFVAYGRSA MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDADEIRDEAGFFDLGMDSL TH_4458|M.thermoresistible__bu DEQAGAGPGAGPGADEIRAWFVAQLAGELGLSPDDIDTGQPFAYYGLDSV Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 TGEVSAATGEASAFDVTALRDLVVAGLRADFHLVEQYRAEPKPPVDAPIL MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 MAVELRRRIEQGVGKDIPVTLVMDHPRLSDAADYLLVEVLGLGEQTNVRQ TH_4458|M.thermoresistible__bu RAIQLMTALEAWSGIKVAPTLAYDHPTIDLAAEHLAGLTHTATSTAADAG Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 ALWGDDEAIDPADMDLWADVTRGGYRSATFPGGHFYLAAERDAVLETVRQ MAV_3107|M.avium_104 ----------------MPPTDVAIIGMACRFPGAPDPGSFWRLLRD---- MSMEG_0408|M.smegmatis_MC2_155 AST----------VTARTDDPIAVVAVSCRFPGAPDPESFWELLAGGVDA TH_4458|M.thermoresistible__bu VSTGAGRRPEHGPAPDRADEPIAIIGIGCRFPGADGPAAYWRLLREGRDA Mb2960|M.bovis_AF2122/97 --------------MSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKES Rv2935|M.tuberculosis_H37Rv --------------MSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKES MLBr_02353|M.leprae_Br4923 --------------MITPDNAIAVVGMAGKFPGANDVSAFWTNLRRGKES MMAR_1772|M.marinum_M -------------MSTIPDNAIAVVGMAGKFPGAKDVSTFWSNLRRGKES MUL_2015|M.ulcerans_Agy99 -------------MSTIPDNAIAVVGMAGKFPGAKDVSTFWSNLRRGKES Mflv_3390|M.gilvum_PYR-GCK MTSGTRDSTSDSPQDSLPDNAIAVIGMAGRFPGAQSVSEFWRNLRGGVES Mvan_3123|M.vanbaalenii_PYR-1 MTSGASNNT-----DELPDNAIAVIGMAGRFPGAGSVSEFWRNLRNGVES MAB_2256|M.abscessus_ATCC_1997 WWAELDGESEASEVHEVRDDDVAVIGIAARVPGAASLDEFWTNLCAGEES :*::.:. :.*** . :* * MAV_3107|M.avium_104 ----------------------GREVTRFAG---EAAEFDADFFNLSPRE MSMEG_0408|M.smegmatis_MC2_155 IREVPEDRWDIDEFYDPDPDTPGKTYTRFGGFLDGIDGFDPEFFGISPRE TH_4458|M.thermoresistible__bu ITATPPERWDTDS---------VGDGTRWGGFLERIDGFDAGFFGISPRE Mb2960|M.bovis_AF2122/97 IVTLSEQELRDAGVSDKTLA--DPAYVRRAPLLDGIDEFDAGFFGFPPLA Rv2935|M.tuberculosis_H37Rv IVTLSEQELRDAGVSDKTLA--DPAYVRRAPLLDGIDEFDAGFFGFPPLA MLBr_02353|M.leprae_Br4923 IVTLSEQELRDNGVSDKALA--DPAYVRRAPLLDGIDEFDADFFGLPPLA MMAR_1772|M.marinum_M IVTLSEEELREAGVSDKTLA--DPSYVRRAPLVDGIDEFDADFFGFPPLA MUL_2015|M.ulcerans_Agy99 IVTLSEEELREAGVSDKTLA--DPSYVRRAPLVDGIDEFDADFFGFPPLA Mflv_3390|M.gilvum_PYR-GCK IVDLSESELLAAGVTEQTLA--NRSYVRRAALMSGIEEFDADFFGFTPQA Mvan_3123|M.vanbaalenii_PYR-1 IVDLPEDELLANGVTERTLS--NRSYVRRAGLMPGIDEFDADFFGFTPYA MAB_2256|M.abscessus_ATCC_1997 LTRFTDEELLSAGVTPEELR--DPRLVRVRPILADVADFDTKFFGYAPSE .* **. **. .* MAV_3107|M.avium_104 AAAMDPRQRLALELAWELLEDAFIVAETLRGEA---------VSVYLGAM MSMEG_0408|M.smegmatis_MC2_155 AVWIEPQQRLMLETVWEGLERAGYAPSDLRGSR---------TGVFTGVA TH_4458|M.thermoresistible__bu AVRIDPQQRLLLEVAWEALEDAGLVPDRLAGSR---------TGVFTGVS Mb2960|M.bovis_AF2122/97 AQVLDPQHRLFLQCAWHALEDAGADPARFDGSIGVYGTSSPSGYLLHNLL Rv2935|M.tuberculosis_H37Rv AQVLDPQHRLFLQCAWHALEDAGADPARFDGSIGVYGTSSPSGYLLHNLL MLBr_02353|M.leprae_Br4923 AQVLDPQHRLFLQCAWHALEDAGCDPAQFDGSIGVYGTSSPSGYLLHNLL MMAR_1772|M.marinum_M AQVLDPQHRLFLQCAWHALEDANCDPAKFDGSIGVYGTSSPSGYLLHNLL MUL_2015|M.ulcerans_Agy99 AQVLDPQHRLFLQCAWHALEDANCDPAKFDGSIGVYGTSSPSGYLLHNLL Mflv_3390|M.gilvum_PYR-GCK AKALDPQHRLFLQTVFHAFEDAGYDPKGLEATVGVFGTSSTSGYLLHNLM Mvan_3123|M.vanbaalenii_PYR-1 ARMLDPQHRLFLQTVFHAMEDAGYDPKGLEATVGVFGTSSSSGYLLHNLM MAB_2256|M.abscessus_ATCC_1997 ARSIDPQQRLFLECAWEAVESAGYDLQRYDGSVGVFGGSAGSTYYRAVLS * ::*::** *: .:. .* * . MAV_3107|M.avium_104 TDDYAALTLRDVPDNVDHHTFTGVSRGMIANRISYLLGLRGASMTVDSGQ MSMEG_0408|M.smegmatis_MC2_155 ANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGFEGPAVAVDTAC TH_4458|M.thermoresistible__bu TYDYLHLQLSHP-ELIDAYSGTGTASSIAANRLSYVFDFRGPSLTLDSAC Mb2960|M.bovis_AF2122/97 SHRDPNAVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTAC Rv2935|M.tuberculosis_H37Rv SHRDPNAVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTAC MLBr_02353|M.leprae_Br4923 SHRDPHTVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTAC MMAR_1772|M.marinum_M SHRDPNTVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTAC MUL_2015|M.ulcerans_Agy99 SHRDPNTVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTAC Mflv_3390|M.gilvum_PYR-GCK SNYDPMMVIGQGASFDMVSLSLSNDKDHLATRVAHSYDLRGPALSVATAC Mvan_3123|M.vanbaalenii_PYR-1 SNFDPMMVIGQGASFEMVNLSLQNDKDHLATRAAHQFDFRGPALSVATAC MAB_2256|M.abscessus_ATCC_1997 TDYG------NLNGTEYLQTALATENDFLAPRVSYKLNLRGPSISLGTGC : . . : * :. .:.*.:::: :. MAV_3107|M.avium_104 SSSLVAVHLGCESVRSGQAPLAIAGGVHLNLADEIALLEREFGAVSVSGH MSMEG_0408|M.smegmatis_MC2_155 SSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVAASRARMLSPVGR TH_4458|M.thermoresistible__bu SSSLVAVHQACRSLRDGECDLALAGGVNIMLSAGIGLNFTRAGVMATDGR Mb2960|M.bovis_AF2122/97 SSSLVAVHLACLSLLSGECDMALAGGSSLCIPHRVGYFTSPGSMVSAVGH Rv2935|M.tuberculosis_H37Rv SSSLVAVHLACLSLLSGECDMALAGGSSLCIPHRVGYFTSPGSMVSAVGH MLBr_02353|M.leprae_Br4923 SSSLVALHLACLSLLSGECDMALAGGSSLCIPHRVGYWHSPGSMVSAVGH MMAR_1772|M.marinum_M SSSLVAVHLACLSLLSGECDVALAGGSSLCVPHHVGYFTSPGSMVSAVGH MUL_2015|M.ulcerans_Agy99 SSSLVAVHLACLSLLSGECDVALAGGSSLCVPHHVGYFTSPGSMVSAVGH Mflv_3390|M.gilvum_PYR-GCK SSSLVAVHLACQSILNGECDIALAGGSSLRIPNRVGYWYAQGSMVTPTGQ Mvan_3123|M.vanbaalenii_PYR-1 SSSLVAVHLACQSLLNGECDIALAGGSSLRIPHHVGYWYEQGAMVSPTGQ MAB_2256|M.abscessus_ATCC_1997 STSLVAIHLAVQSVLTGESDMALAGGASITFPQTAGYVATESGAISTSGR *::***:* . :: *:. :*:*** : .. :: *: MAV_3107|M.avium_104 TYAFDRRADGYVRGEGGGLVLLKPLAAARRDGDRIHAVIRATAVGNAGHG MSMEG_0408|M.smegmatis_MC2_155 CKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIPASSVNQDGAS TH_4458|M.thermoresistible__bu CKTFDARADGWVRGEGAGIVVLKPLREALADEDPIYAVIRGSAVNQDGRT Mb2960|M.bovis_AF2122/97 CRPFDVRADGTVFGSGVGLVVLKPLAAAIDAGDRIHAVIRGSAINNDGSA Rv2935|M.tuberculosis_H37Rv CRPFDVRADGTVFGSGVGLVVLKPLAAAIDAGDRIHAVIRGSAINNDGSA MLBr_02353|M.leprae_Br4923 CRPFDVRADGTVFGSGVALVALKPLQAAIDASDRIHAVILGSAINNDGSM MMAR_1772|M.marinum_M CRPFDVRSDGTVFGSGVAMVVLKPLQAAIDAGDRIHAVIRGSAINNDGSA MUL_2015|M.ulcerans_Agy99 CRPFDVRSDGTVFGSGAAMVVLKPLQAAIDAGDRIHAVIRASAINNDGSA Mflv_3390|M.gilvum_PYR-GCK CRPFDVRADGTVFGSGVGVLVLKALEDAVADGDRIHAVIRGSALNNDGAT Mvan_3123|M.vanbaalenii_PYR-1 CRPFDVRSDGTIFASGVGVVVLKALADAIDDGDHIHAVIRGSALNNDGST MAB_2256|M.abscessus_ATCC_1997 CRAFDASADGTLVGDGIGIVLLKRASNAVADGDSILGIIRGTAVNNDGGN .** :** : ..* .:: ** * * : .:* .:::.: * MAV_3107|M.avium_104 APAQTLPSAAAEADVIGRALAEAGLGGADIDYVEAHGTGTRVGDAVETQA MSMEG_0408|M.smegmatis_MC2_155 S-GLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTPLGDPIEVQA TH_4458|M.thermoresistible__bu N-GLMAPSRTAQEVVLTDAYRRAGVSPGVVQYVEAQGIGTPVGDAIEVGA Mb2960|M.bovis_AF2122/97 KMGYAAPNPAAQADVIAEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQG Rv2935|M.tuberculosis_H37Rv KMGYAAPNPAAQADVIAEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQG MLBr_02353|M.leprae_Br4923 KMGYAAPNPAAQADVIAEAHAVAGIDSSTVSYVETHGTGTPLGDPIEIQG MMAR_1772|M.marinum_M KMGYAAPNPAAQADVIAEAHAVSGIDASTVSYVECHGTGTPLGDPIEIQG MUL_2015|M.ulcerans_Agy99 KMGYAAPNPAAQADVIAEAHAVSGIDASTVSYVECHGTGTPLGDPIEIQG Mflv_3390|M.gilvum_PYR-GCK KMTYAAPNALGQAEVIAEAHAIAGVDASTITYVETHGTGTPLGDPIEVEG Mvan_3123|M.vanbaalenii_PYR-1 KMTYAAPNALGQAEVIAEAHAIAGVDASSITYVETHGTGTPLGDPIEIEG MAB_2256|M.abscessus_ATCC_1997 KAGFAAPSISGQVEVITEALAVAEVPAQTVDYVETHGTGTPLGDPIEIAA *. .: :: : : : : *:* :* ** :**.:* . MAV_3107|M.avium_104 LGRIFAER---SHHPVSVGSVKTNIGHAASAAGIAGLLKAVLAIEHAAIP MSMEG_0408|M.smegmatis_MC2_155 AAAAYGAGRD-ADRPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHGVLP TH_4458|M.thermoresistible__bu LGTVLAEDRP-PDSPCLIGSVKTNIGHLEAAAGIAGLIKVALALRHRMIP Mb2960|M.bovis_AF2122/97 LRAAFEVSQTSRSAPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKALP Rv2935|M.tuberculosis_H37Rv LRAAFEVSQTSRSAPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKALP MLBr_02353|M.leprae_Br4923 LKTAFEVSQIPRPGPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKAIP MMAR_1772|M.marinum_M LRTAFEASETTRTGPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNRAIP MUL_2015|M.ulcerans_Agy99 LRTAFEASETTRTGPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNRAIP Mflv_3390|M.gilvum_PYR-GCK LRQAFELAEDERSAPCYLGSVKSNIGHLETAAGIAGLIKAILCLEHKAIP Mvan_3123|M.vanbaalenii_PYR-1 LRQAFELSEETRSAPCYLGSVKSNIGHLETAAGIAGLIKAILCLEHKAIP MAB_2256|M.abscessus_ATCC_1997 LHKAFREAGDTRTQACRLGTLKPNIGHTGPASGVLALIKVLLAFQHRMYP . :*::*.**** *:* .*:*. *.:.: * MAV_3107|M.avium_104 PNLHFERPDPDIDLNRLGLRVNTALAPWPDRGG-PRRAGVSSFGMGGTNA MSMEG_0408|M.smegmatis_MC2_155 QSLHFENPSPHIPWDALPVRVIDEPVPWQTNGR-VRRAGVSSFGFTGTNA TH_4458|M.thermoresistible__bu PTLNFTEPNPTIEFDKLPVRVAQTLTPWPDDSG-RAVAGVSAFGFGGTNA Mb2960|M.bovis_AF2122/97 ATLHYTSPNPELRLDQSPFVVQSKYGPWECDG--VRRAGVSSFGVGGTNA Rv2935|M.tuberculosis_H37Rv ATLHYTSPNPELRLDQSPFVVQSKYGPWECDG--VRRAGVSSFGVGGTNA MLBr_02353|M.leprae_Br4923 ATLHYTSPNRELRLDQTPFVVQSNYGPWKWDG--VRRAGVSSFGVGGTNV MMAR_1772|M.marinum_M ATLHYTSPNPELRLEQSPFVVQNKYGPWEWDG--VLRAGVSSFGVGGTNA MUL_2015|M.ulcerans_Agy99 ATLHYTSPNPELRLEQSPFVVQNKYGPWEWDG--VLRAGVSSFGVGGTNA Mflv_3390|M.gilvum_PYR-GCK ATLHYTSPNPELHLDRGPFRVRAQDGPWESDG--IRRAGVSSFGVGGTNA Mvan_3123|M.vanbaalenii_PYR-1 ATLHYTSPNPELHLDRGPFRIRSSDGPWESDG--IRRAGVSSFGVGGTNA MAB_2256|M.abscessus_ATCC_1997 PAANFTAPNPQIEFSKSPFYVGTRLRRWNAPGGKPRRAGVSSYSMGGTNA :: *. : . . : * . ****::.. ***. MAV_3107|M.avium_104 HVIVEQDAAQQNPTPAS--APADVALP--------WVLSARSERALALQA MSMEG_0408|M.smegmatis_MC2_155 HVLVEEAPPQLHTADAAPVEPAATAEAGTDDSPQVLALSARSPEALVELA TH_4458|M.thermoresistible__bu HVVLAEAPQVRAAATADDHADGFVEILP---------LSARSQAALDALA Mb2960|M.bovis_AF2122/97 HVVLEEAPAEASEVSAHAEPAGPQVIL----------LSAQTAAALGESR Rv2935|M.tuberculosis_H37Rv HVVLEEAPAEASEVSAHAEPAGPQVIL----------LSAQTAAALGESR MLBr_02353|M.leprae_Br4923 HVVLEEASVEASTVAAS---TGPQVIL----------LSAQTAAALGESR MMAR_1772|M.marinum_M HVVLEEAP----TVPAHDEPAGPQVLL----------LSAQTAAALTESR MUL_2015|M.ulcerans_Agy99 HVVLEEAP----TVPAHDEPAGPQVLL----------LSAQTAAALTESR Mflv_3390|M.gilvum_PYR-GCK HIILEEAP-VAPARAQTSSPARPSVLV----------LSARTQEALEDSR Mvan_3123|M.vanbaalenii_PYR-1 HIVLEEAP-TAPVPAPRSG---PQVLV----------LSARTEETLAQSR MAB_2256|M.abscessus_ATCC_1997 HAVLQEPP---RAELPPKSQEGAHLLV----------LSARTAPALEAAR * :: : . ***:: :* MAV_3107|M.avium_104 QRLSAHLAERPQASPLDVGWSLVSARAVFEHRAVLVGCERGVLATGLAGV MSMEG_0408|M.smegmatis_MC2_155 RRYDDWLSATPGLDIADVCHTAGVGRSHFEYRAALVVDSVERAREGLAAL TH_4458|M.thermoresistible__bu ERYESALTG--GVPPADLCHTAGARRAHHDHRLAVVGASRAELIGALAAY Mb2960|M.bovis_AF2122/97 TALAAALETQDGPRLSDVAYTLAR-RRKHNVTMAAVVHDREHAATVLRAA Rv2935|M.tuberculosis_H37Rv TALAAALETQDGPRLSDVAYTLAR-RRKHNVTMAAVVHDREHAATVLRAA MLBr_02353|M.leprae_Br4923 EALATVLEKPGAPDLSDVAYTLAG-RRKHNITMAAVVRDREHAVTVLRAA MMAR_1772|M.marinum_M TALAEVLERSDSPDLSDVAYTLSR-RRKHNVTMAAVVSDREEAATALRAA MUL_2015|M.ulcerans_Agy99 TALAEVLGRSDSPDLSDVAYTLSR-RRKHNVTMAAVVSDREEAATALRAA Mflv_3390|M.gilvum_PYR-GCK ATLARELGENAEISLPDVAYTLGR-RRKEPIRLAAVVRDQANAATVLSAA Mvan_3123|M.vanbaalenii_PYR-1 AALAAELSEVDEISLPDAAYTLTH-RRKDPVRLAAVVHDQENAATVLSAA MAB_2256|M.abscessus_ATCC_1997 KNLAHHLARHPEQDLAAVAATLRLGRRAFSHRFAAVCADRPEALQVLEGT * : * . * . * . MAV_3107|M.avium_104 ASGRPDAATVVG--------------RARATGKTVLVFPGQGSQTLGMGR MSMEG_0408|M.smegmatis_MC2_155 AEGRTPAGVVRG--------------EHVHRPTTAWLFTGQGSQYPGMAR TH_4458|M.thermoresistible__bu RRGEPHPGVFTGR------------SQSGHRSGVVFVFSDEGSQWRGMAQ Mb2960|M.bovis_AF2122/97 EHD----NVFVGEAAHDGEHGDRADAAPT-SDRVVFLFPGQGAQHVGMAK Rv2935|M.tuberculosis_H37Rv EHD----NVFVGEAAHDGEHGDRADAAPT-SDRVVFLFPGQGAQHVGMAK MLBr_02353|M.leprae_Br4923 EHD----NVFVGESGADTGRSAAASITTLGSDRVVFLFPGQGAQHVGMAK MMAR_1772|M.marinum_M DND----SIFVGESVAG-----VADATAAAAERVVFLFPGQGAQHVGMAK MUL_2015|M.ulcerans_Agy99 DND----SIFVGESVAG-----VADATAAAAERVVFLFPGQGAQHVGMAK Mflv_3390|M.gilvum_PYR-GCK ETDGATDNVFIGR--------GHPDWDSSATDRIAFLFPGQGAQHIGMAR Mvan_3123|M.vanbaalenii_PYR-1 ETD----NVFIGR--------AVPDLQDSA-ERVAFLFPGQGAQHVGMAR MAB_2256|M.abscessus_ATCC_1997 GHAP-----------------FRTGTAADKPRPVVFLFPGQGSQFSGMGE . :*..:*:* **.. MAV_3107|M.avium_104 QLYERFVVFARALDEAVAVVDEHSRLSVREVMWGAD-----PELLQSTEF MSMEG_0408|M.smegmatis_MC2_155 ELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRE--TADLLQHTSF TH_4458|M.thermoresistible__bu RLYAEDQVFRTALAECDRALRRHMEISPLSELLADP----SHSRMDEVTI Mb2960|M.bovis_AF2122/97 GLYDTEPVFAQHFDTCAAGFRDETG-IDLHAEVFDG----TATDLERIDR Rv2935|M.tuberculosis_H37Rv GLYDTEPVFAQHFDTCAAGFRDETG-IDLHAEVFDG----TATDLERIDR MLBr_02353|M.leprae_Br4923 GLYDTESVFAEHFDTCSAGFREAMDDLDLHSAIFNG----TAIDLERIDR MMAR_1772|M.marinum_M GLYETEPVFAEHFDACAAGFRAEMG-VDLNAEIFNG----TATDLERIDR MUL_2015|M.ulcerans_Agy99 GLYETEPVFAEHFDACAAGFRAEMG-VDLNAEIFNG----TGTDLERIDR Mflv_3390|M.gilvum_PYR-GCK GLHDNEPVFARYFDECATAFSDEMG-FDLRAEIFDG----VGRNLEHTDR Mvan_3123|M.vanbaalenii_PYR-1 GLYDNEPVFKRHFDECATAFSDDMG-YDLRAEIFDG----VGRNLEHTDR MAB_2256|M.abscessus_ATCC_1997 QLYTTSSMYRRHIDECATLFEPLIG-VDLRTMLCAEGDEATDAALMQTRL *. :: . . . : MAV_3107|M.avium_104 AQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAGVLSLRDAAR MSMEG_0408|M.smegmatis_MC2_155 AQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDDGAR TH_4458|M.thermoresistible__bu ASPALFAVQVALAALWQSWGVEPAAVIGHRMGEVAAAHVAGVLGLDDAAA Mb2960|M.bovis_AF2122/97 SQPALFTVEYALAKLVDTFGVRAGAYIGYSTGEYIAATLAGVFDLQTAIK Rv2935|M.tuberculosis_H37Rv SQPALFTVEYALAKLVDTFGVRAGAYIGYSTGEYIAATLAGVFDLQTAIK MLBr_02353|M.leprae_Br4923 SQPALFTVEYALAKLVESFGVGAGAYIGYSTGEYIAATLAGVFDLETAIK MMAR_1772|M.marinum_M SQPALFTVEYALAKLVDTYGVRAGAYIGYSTGEYIAATLAGVFDLETAIK MUL_2015|M.ulcerans_Agy99 SQPALFTVEYALAKLVDTYGVRAGAYIGYSTGEYIAATLAGVFDLETAIK Mflv_3390|M.gilvum_PYR-GCK AQPALFTVEYALARLIQSYGVEPAIMAGHSIGEYPAATLAGVFDLDTAVK Mvan_3123|M.vanbaalenii_PYR-1 AQPALFTVEYALAKLVQSYGVEPAIMAGHSIGEYPAATIAGVFDLDTAVK MAB_2256|M.abscessus_ATCC_1997 TQPALFTVGYALSQLLGAWGVQPVAMLGHSIGELVAACAAGVFTIEEAVQ :.****.. .*: * : .: . *: *: ** ***: : . MAV_3107|M.avium_104 LVAARGALMAALPPGGVMVAVTATEAQVAPLVGGG---VSIAAVNGPDAV MSMEG_0408|M.smegmatis_MC2_155 LMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFP-RVSVGAYNGP-NT TH_4458|M.thermoresistible__bu LLCGRTRLSRLASTG----------------------------------- Mb2960|M.bovis_AF2122/97 TVSLRARLMHESPPGAMVAVALGPDDVTQYLPP----EVELSAVNDPGNC Rv2935|M.tuberculosis_H37Rv TVSLRARLMHESPPGAMVAVALGPDDVTQYLPP----EVELSAVNDPGNC MLBr_02353|M.leprae_Br4923 TVSLRARLMHESPPGAMVAVALGPEDITEYLAEYSAKGVELSAVNDPGNC MMAR_1772|M.marinum_M TVSLRARLMHESPPGAMVAVAVGPDEIAQYLGD----GVELSAVNDPGNC MUL_2015|M.ulcerans_Agy99 TVSLRARLMHESPPGAMVAVAVGPDDFAQYLGD----GVELSAVNDPGNC Mflv_3390|M.gilvum_PYR-GCK VVATRAKLMHAAPRGVMIAVPLSPDAVAEYLTP----DVDIATINDPGSC Mvan_3123|M.vanbaalenii_PYR-1 VVSKRAKLMHAAPRGVMVAVPLSPEAVAEHLTP----DVDVATINDPGSC MAB_2256|M.abscessus_ATCC_1997 LAARRGDLIQQCPSGAMAAVGGSLEVVSALLPEG----VSVAAVNGPEQI . * : . * MAV_3107|M.avium_104 VLSGEQEAVSAVAERLAGSGARVHRLAVSHAFHSALMEPMLDGFAAAAAG MSMEG_0408|M.smegmatis_MC2_155 VLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAYAAQ TH_4458|M.thermoresistible__bu --------------------------------------AVREGLDGLLAN Mb2960|M.bovis_AF2122/97 VVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHTSAMDPMLGQFQEFLSR Rv2935|M.tuberculosis_H37Rv VVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHTSAMDPMLGQFQEFLSR MLBr_02353|M.leprae_Br4923 VVAGPKDQIRAFSQRLDEVGIPVRRVRATHAFHTSSMEPMLREFSEFLSR MMAR_1772|M.marinum_M VVAGPKDEIRAFSQRLNEAGIPVRRVRATHAFHSSSMEPMLGEFQEFLSR MUL_2015|M.ulcerans_Agy99 VVAGPKDEIRAFSQRLNEAGIPVRRVRATHAFHSSSMEPMLGEFQEFLSR Mflv_3390|M.gilvum_PYR-GCK VVAGTDEAIRAFQAGLAEKGVAARRVRTAHAFHSRLMDPVVAEFTAFLSG Mvan_3123|M.vanbaalenii_PYR-1 VVAGSEEAIRTFQAALAEKGVAARRVRTSHAFHSRLMDPVVAEFGAFLSG MAB_2256|M.abscessus_ATCC_1997 VVAGREEGIEALLSTGANVGVRCTRLPVNRGFHSALVDPAVSSFSAAVAR . : : MAV_3107|M.avium_104 IEPRPPRIPLVSNLTG-QLAGPGYGTPQYWVEHVRRPVRFVDGVRLAESQ MSMEG_0408|M.smegmatis_MC2_155 FQFAAPTLPLVCNRTGAVLTGQTPLDAQYWRRHSRQPVQFAESVRTVAAL TH_4458|M.thermoresistible__bu LRPDDPRIPLYSTVTGDAVTGRGFG-AAHWMENLHSPVRFSAAVRRLLGR Mb2960|M.bovis_AF2122/97 QQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQISSPIRFADELDVVLAA Rv2935|M.tuberculosis_H37Rv QQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQISSPIRFADELDVVLAA MLBr_02353|M.leprae_Br4923 QQLRVPNTPLLSNLTGTWMSEQQVTDPENWTRQISSTIRFADELDVVLSQ MMAR_1772|M.marinum_M QQLRAPQTPLLSNLTGTWLSEQQVTDPATWARQISSTVRFADELDVVLSQ MUL_2015|M.ulcerans_Agy99 QQLRAPQTPLLSNLTGTWLSEQQVTDPATWARQISSTVRFADELDVVLSQ Mflv_3390|M.gilvum_PYR-GCK LTLREPQIPLLSNVTGTTMSASEATNPSTWARQIRATVRFADELDALLAA Mvan_3123|M.vanbaalenii_PYR-1 VTLREPQIPLLSNITGTTMTAAEATNPSTWARQIRATVRFADELDALLAA MAB_2256|M.abscessus_ATCC_1997 MRLQQPQVPFISNVTGTWITGAQATEPEYWGRQLRETVQFARGLTTLCAE * *: .. ** :: . * .: .::* : . MAV_3107|M.avium_104 -GAGVFLEVGPGAALTA--AVDQSLSTEGAT--AIATLPKDRPETESALH MSMEG_0408|M.smegmatis_MC2_155 -GCSVLMEIGPQPVLTG--AAVQVWPEHMAAPRAVASLRKGVADRRQIAD TH_4458|M.thermoresistible__bu -GHDAFLEISAHPMLLS--AVQEDAADLGRSCTTLVSMRRGECGRDVLMT Mb2960|M.bovis_AF2122/97 -PSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRLMRHPLQDVDDRDTFLR Rv2935|M.tuberculosis_H37Rv -PSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRLMRHPLQDVDDRDTFLR MLBr_02353|M.leprae_Br4923 -SGRVLVEVGPGGSLTGSAMRHPRWSSGHRAVRLMRHPLQNVDDHDTFLR MMAR_1772|M.marinum_M -PNRILVEIGPGGSLTGSAIRHPKWSDGHRSVRLMRHPIQNLDDRETFLR MUL_2015|M.ulcerans_Agy99 -PNRILVEIGPGGSLTGSAIRHPKWSDGHRSVRLMRHPIQNLDDRETFLR Mflv_3390|M.gilvum_PYR-GCK -PDRVLVEVGPGGTLTSSAGRHPRWSERHRAVRLMRHQAQNRSDDDTFHL Mvan_3123|M.vanbaalenii_PYR-1 -PDRVLVEVGPGGTLTSSAGRHPKWTERHRAVRLMRHQAQNRNDHDTFLL MAB_2256|M.abscessus_ATCC_1997 YPDALLVEVGPGHTLRGIVAAN---TPASEVVSMLGDRTG--DSATVALA ::*:.. * . . : MAV_3107|M.avium_104 AAGHLFTRGHRLDWAGVFAG--LPARRVDLPTYAFARERFWLGGASLAGA MSMEG_0408|M.smegmatis_MC2_155 ALASAYVGGHRPDFAAVHR---QPRRPVELPTYPFQRRRFWPKASSIAVD TH_4458|M.thermoresistible__bu SLAALYASGHAVDWARVHP---HGSHCTAAPTYPWQRQRFWLDIDRCDTG Mb2960|M.bovis_AF2122/97 ALGELWSAGVEVDWTPR---RPAVPHLVSLPGYPFARQRHWVEPNHTVWA Rv2935|M.tuberculosis_H37Rv ALGELWSAGVEVDWTPR---RPAVPHLVSLPGYPFARQRHWVEPNHTVWA MLBr_02353|M.leprae_Br4923 ALGELWSAGIEVDWAPQ---RSVMPHLVSLPGYPFARQRHWVEPRYTIWA MMAR_1772|M.marinum_M ALGELWSAGVDVDWTPR---RAASPRIVSLPGYPFARQRHWVEPKHMAWA MUL_2015|M.ulcerans_Agy99 ALGELWSAGVDVDWTPR---RAASPRIVSLPGYPFARQRHWVEPKHMAWA Mflv_3390|M.gilvum_PYR-GCK ALGQLWAADVDVDWTQGDQDAADARTLVTLPGYPFARQRHWVEYN----A Mvan_3123|M.vanbaalenii_PYR-1 ALGQLWAADVEVDFNQG---AEEDRTLITLPGYPFAKQRHWVEHN----A MAB_2256|M.abscessus_ATCC_1997 AAGRLWAGGAELAWQHFG----ASRPRVPLPTYPFERERLWMSPP----- : . : . : * *.: :.* * MAV_3107|M.avium_104 PAGAAP--VGGG-------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 GGTAASGILGSGKDLASGDTIYTSRLSVKSQPWLADHVIYGTVVVPGATY TH_4458|M.thermoresistible__bu DGAGTGGTAERTVVPAP--------------------------------- Mb2960|M.bovis_AF2122/97 QAPGANNGSPAGTADGSTA--ATVDAARNG-------------------- Rv2935|M.tuberculosis_H37Rv QAPGANNGSPAGTADGSTA--ATVDAARNG-------------------- MLBr_02353|M.leprae_Br4923 QIPGASSGSPVDSSVDS----ATVEGVRGG-------------------- MMAR_1772|M.marinum_M QIPTASNGSSVGAKLGSGADSGIRGGAQTG-------------------- MUL_2015|M.ulcerans_Agy99 QIPTASNGSSVGAKLGSGADSGIRGGAQTG-------------------- Mflv_3390|M.gilvum_PYR-GCK SSAWVANGSGAAGVSATGAQAGSAAGGAGG-------------------- Mvan_3123|M.vanbaalenii_PYR-1 NAAWLAGGAGADGTAAAAGSAGVAPVAAGG-------------------- MAB_2256|M.abscessus_ATCC_1997 ---RSVLDKPVQAPIAPAVQVPLVTASTQT-------------------- MAV_3107|M.avium_104 ----------------------------------------TRAPELAHRL MSMEG_0408|M.smegmatis_MC2_155 AAMALAAVGTPARLKDVFFYEPIILPEKASREVQLTLHPADGGSVLSFQI TH_4458|M.thermoresistible__bu ----------------------------------LPAPSASAAPTVDEVL Mb2960|M.bovis_AF2122/97 -----------------------------------ESQTEVTLQRIWSQC Rv2935|M.tuberculosis_H37Rv -----------------------------------ESQTEVTLQRIWSQC MLBr_02353|M.leprae_Br4923 -----------------------------------ESQTEATLQRIWSQC MMAR_1772|M.marinum_M -----------------------------------ESQTEDVLQRIWSQC MUL_2015|M.ulcerans_Agy99 -----------------------------------ESQTEDVLQRIWSQC Mflv_3390|M.gilvum_PYR-GCK -----------------------------------GSSVEASLQRIWAQC Mvan_3123|M.vanbaalenii_PYR-1 -----------------------------------TSTVEAKLARIWSQC MAB_2256|M.abscessus_ATCC_1997 -----------------------------------DVPDAAVVEQIWCEA : MAV_3107|M.avium_104 HALPRDEQQRVLRELVCEHAAAVLGHPGGDAIDPD--------------- MSMEG_0408|M.smegmatis_MC2_155 HSRPYGER-GADWSLNAEGTVDTAGSDPDAAADEQSDPVDEVIERLERMR TH_4458|M.thermoresistible__bu LCADQRERRELLESYLRDRVAAELGVLPPLLDVAAP-------------- Mb2960|M.bovis_AF2122/97 LGVSSVDRNANFFDLGGDSLMAISIAMAAANEGLTITPQDLYEYPTLASL Rv2935|M.tuberculosis_H37Rv LGVSSVDRNANFFDLGGDSLMAISIAMAAANEGLTITPQDLYEYPTLASL MLBr_02353|M.leprae_Br4923 LGVSSVDRNANFFDLGGDSLMAISISMAAANEGMTITPQDMYEHPTLASL MMAR_1772|M.marinum_M LGVGSVDRNANFFDMGGDSLMAISIAMSAANEGLTITPQDLYEHPTLASL MUL_2015|M.ulcerans_Agy99 LGVGSVDRNANFFDMGGDSLMAISIAMSAANEGLTITPQDLYEHPTLASL Mflv_3390|M.gilvum_PYR-GCK LGVNEIDRHANFFEIGGDSLVAISVAMTAGHAGLDLTPQDLYENQTVASL Mvan_3123|M.vanbaalenii_PYR-1 LGLSDIDRNANFFEIGGDSLIAISVAMTAGHEGLDLTPQDLYENQTVAAL MAB_2256|M.abscessus_ATCC_1997 LGVPSVESDDNFFDLGGDSLIAARVVTAIGER-----------CHIKVSV : . : MAV_3107|M.avium_104 -----RAFADLGFDS----------------------LIGVELRNRLTTH MSMEG_0408|M.smegmatis_MC2_155 PQDLFETFADLELAWGPTWSGSLKSLWLGDGEAVGDILVGAELAEQLGSE TH_4458|M.thermoresistible__bu -------LSTLGIDS----------------------LTAAELRARVERD Mb2960|M.bovis_AF2122/97 TAAVDASFASSGLAKP----------------------PEAQANPAVPPN Rv2935|M.tuberculosis_H37Rv TAAVDASFASSGLAKP----------------------PEAQANPAVPPN MLBr_02353|M.leprae_Br4923 TAAVDASFASSGLAKP----------------------PEAAAHPAVPPN MMAR_1772|M.marinum_M TAAIDASFASSGLAKP----------------------PEADANPAVPPN MUL_2015|M.ulcerans_Agy99 TAAIDASFASSGLAKP----------------------PEADANPAVPPN Mflv_3390|M.gilvum_PYR-GCK AKVLTARYAEGGLARQS---------------------VDDSTSPPVPPN Mvan_3123|M.vanbaalenii_PYR-1 AKVLTARYAEGGLARQT---------------------LDDAVNPPVPPN MAB_2256|M.abscessus_ATCC_1997 AELWDQGATLADLAELV---------------------ERRAINSKVGEQ : : : . MAV_3107|M.avium_104 TGTALSRTLIFDYPTPAALADHLRQQLLHD-------------------- MSMEG_0408|M.smegmatis_MC2_155 PMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLAEKMPRRF TH_4458|M.thermoresistible__bu LGIVIPVAQLLNGPSVSDLAEWISTTMVGFG------------------- Mb2960|M.bovis_AF2122/97 VTYFLDRGLRDTGRCRVPLILRLDPKIGLPD------------------- Rv2935|M.tuberculosis_H37Rv VTYFLDRGLRDTGRCRVPLILRLDPKIGLPD------------------- MLBr_02353|M.leprae_Br4923 IAYFLERGLCDTGRWRVPLILRLDPKIGSDD------------------- MMAR_1772|M.marinum_M IAYFLDRGLRDTGRWRVPLILRLDPQVGPED------------------- MUL_2015|M.ulcerans_Agy99 IAYFLDRGLRDTGRWRVPLILRLDPQVGPED------------------- Mflv_3390|M.gilvum_PYR-GCK VAYFLEHGLRDVGRWRIPVILGLRSDVGEDD------------------- Mvan_3123|M.vanbaalenii_PYR-1 VAYFLEHGLRDIGRWRIPVILGLRSDVGEDD------------------- MAB_2256|M.abscessus_ATCC_1997 LK------------------------------------------------ MAV_3107|M.avium_104 ------EDPESDDE-------------RIWSALRRIPLRELRRTGLLDKL MSMEG_0408|M.smegmatis_MC2_155 YCRARWHRSALDSETQVFELEFVDLGGRALGGIREFTVKRAPREALLRGL TH_4458|M.thermoresistible__bu -----STTPEPESAG---------VPGRSRPPDGAVASGSGDGGRWIELL Mb2960|M.bovis_AF2122/97 ------IRAVLTAVVNHHDALRLHLVGNDGIWEQHIAAPAEFTGLSNRSV Rv2935|M.tuberculosis_H37Rv ------IRAVLTAVVNHHDALRLHLVGNDGIWEQHIAAPAEFTGLSNRSV MLBr_02353|M.leprae_Br4923 ------IRAVLTAVVNHHDVLRLSLVDNDGMWEQHIAATGEFTRLLTQTL MMAR_1772|M.marinum_M ------IRAVLSAVTNHHDALRLRLVENGGVWEQHIAAPADFTELATRQL MUL_2015|M.ulcerans_Agy99 ------IRAVLSAVTNHHDALRLRLVENGGVWEQHIAAPADFTELATRQL Mflv_3390|M.gilvum_PYR-GCK ------VRAVLTAVTDAHDVLRVRLVERSGIWDQIIAEPGEFTELASREL Mvan_3123|M.vanbaalenii_PYR-1 ------VRAVLTAVTEVHDALRVHLVERAGTWDQHIAEPGEFTELVARQL MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 ----------------------------LLLAGMPETAT----------- MSMEG_0408|M.smegmatis_MC2_155 GGDATRLLYTLGWHEVPPPPSADDAVGTWLIAGFDELAAKVPGCVPIDRN TH_4458|M.thermoresistible__bu N------------------------------------------------- Mb2960|M.bovis_AF2122/97 PDG--------------------------VAAGSPEERAAVLGILAELLE Rv2935|M.tuberculosis_H37Rv PNG--------------------------VAAGSPEERAAVLGILAELLE MLBr_02353|M.leprae_Br4923 PDG--------------------------VAAGSAEERAVVSSILAELIA MMAR_1772|M.marinum_M PGD--------------------------LAAGEADEHGAVSNIVAELIA MUL_2015|M.ulcerans_Agy99 PDD--------------------------LAADEADEHSAVSNIVAELIA Mflv_3390|M.gilvum_PYR-GCK PSG--------------------------VAAGSPQEREAVLAFLDEQVR Mvan_3123|M.vanbaalenii_PYR-1 PEG--------------------------LAAGSPQEREAVLGFLDEQVR MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 TDAKIS------------------------------DADIDSLSPDALIA MSMEG_0408|M.smegmatis_MC2_155 TDLQVLGEVLSQAHARGAGFSGVVWRCATPGRKESGSASAESARLEAEIT TH_4458|M.thermoresistible__bu -----------------------------------QMPEVSDDTVDELLR Mb2960|M.bovis_AF2122/97 DQTDPNAPLAAVHIAAAHGGPHYLCLAIHAMVT----DDSSRQILATDIV Rv2935|M.tuberculosis_H37Rv DQTDPNAPLAAVHIAAAHGGPHYLCLAIHAMVT----DDSSRQILATDIV MLBr_02353|M.leprae_Br4923 SQSDLNEPLTAVQITTAHGGPHYLGLAVHQMVI----DDASRQILGTDII MMAR_1772|M.marinum_M EQGDSNAPLIAVHVTAPNGGAQYLGLALHEMVA----DDASRQLLGADII MUL_2015|M.ulcerans_Agy99 EQGDSNAPLIAVHVTAPNGGAQYLGLALHETVA----DDASRQLLGADII Mflv_3390|M.gilvum_PYR-GCK EH-QVVVPLTATLIRSGSGGPSYLALSLHGIAGDVSGDSASRDVLLTDLF Mvan_3123|M.vanbaalenii_PYR-1 EH-QVVVPLAATFIRGVTGGPSYLALSLHGIAG----DDVSRDVLLTDVF MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 MALNSADDDEAE-------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 NLLSAVHAAQGPSVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGRTT TH_4458|M.thermoresistible__bu QLLAAGENHDDTQLH----------------------------------- Mb2960|M.bovis_AF2122/97 TAFGQRLAGEEITLEPVSTGWREWSLRCAALATHPAALDTRSYWIENSTK Rv2935|M.tuberculosis_H37Rv TAFGQRLAGEEITLEPVSTGWREWSLRCAALATHPAALDTRSYWIENSTK MLBr_02353|M.leprae_Br4923 TAFGQRLAGEEITLEPVTTGWREWSLRCAALATHPAALDTRSFWIENANK MMAR_1772|M.marinum_M TAFAQRLGDQEIKLDPVTTGWRDWSVRCAALATHPAALDTRSYWIEQSTK MUL_2015|M.ulcerans_Agy99 TAFAQRLDDQEIKLDPVTTGWRDWSVRCAALATHPAALDTRSYWIEQSTK Mflv_3390|M.gilvum_PYR-GCK TAFNQRMAGEEIVLAPVTASWREWSQRCAGLAGHPAVLDSRDYWLQTAHR Mvan_3123|M.vanbaalenii_PYR-1 TAFSQRMAGEEIVLAPVPASWREWSQRCAGLASHPAVLDSRDYWLQTAGA MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 INEEPALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 ATLWLADALPNAHTAHPPRADELTKLSSTLSVEQTSELDDGRRRFRRS-- Rv2935|M.tuberculosis_H37Rv ATLWLADALPNAHTAHPPRADELTKLSSTLSVEQTSELDDGRRRFRRS-- MLBr_02353|M.leprae_Br4923 VNLWLADVSLNTDVIQPPGADDLIRMPCTLSVEQTSELDDARRRFRRS-- MMAR_1772|M.marinum_M ANLWLTDG----DAAQPPSATDLTKLPSVLNAEQTSELDDARRRFRRS-- MUL_2015|M.ulcerans_Agy99 ANLWLTDG----DAAQPPSATDLTKLPSVLNAEQTSELDDARRRFRRS-- Mflv_3390|M.gilvum_PYR-GCK STLRVAGG----EPADRPGAADLERLSTMLSAAETGEFDDARRRLRLS-- Mvan_3123|M.vanbaalenii_PYR-1 STLRIAGP----EHSERPGVDDVTRLSTALSAAETGEIDDARRRLRLP-- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LPWARSGHLTLPRGGDFVLAPTERGAIDNLRLTETDVPEPDEGYVQVRVE TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -----IQTILLAALGRTIAQTVGEGVVAVELEGEGRSVLRPDVDLRRTVG Rv2935|M.tuberculosis_H37Rv -----IQTILLAALGRTIAQTVGEGVVAVELEGEGRSVLRPDVDLRRTVG MLBr_02353|M.leprae_Br4923 -----IQAIVLAALGRTIAQTVGDGVVAVELEGEGRSVLRPDVDVRRTIG MMAR_1772|M.marinum_M -----IQTILLAALGRTIAQTVGDGVVAVELDGEGRSVLRPDVDVRRTVG MUL_2015|M.ulcerans_Agy99 -----IQTILLAALGRTIAQTVGDGVVAVELDGEGRSVLRPDVDVRRTVG Mflv_3390|M.gilvum_PYR-GCK -----AEEILLAALGRAVAVTVGEGAVAVDLGGRGRSVLKPDVDLARTVG Mvan_3123|M.vanbaalenii_PYR-1 -----VEEILLAALGRAVAATVGEGAVSVDLGGRGRSVLKPDVDLQRTVG MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 AAGLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGS TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 WFTTYYPVPLACATGLG--ALAQLDAVHNTLKSVPHYGIGYGLLRYVYAP Rv2935|M.tuberculosis_H37Rv WFTTYYPVPLACATGLG--ALAQLDAVHNTLKSVPHYGIGYGLLRYVYAP MLBr_02353|M.leprae_Br4923 WFTNYYPIPLVCVKGQG--ALAQLDAVHNTLKSIPHYGIGYGLLRYMYAP MMAR_1772|M.marinum_M RFTTYYPVALTCATGQGAAALKGLDAVHDTLKSVPHYGIGYGLLRYLYAP MUL_2015|M.ulcerans_Agy99 RFTTYYPVALTCATGQGAAALKGLDAVHDTLKSVPHYGIGYGLLRYLYAP Mflv_3390|M.gilvum_PYR-GCK SFAALHPVVLT-ASGQ--TASAALAEVRQTLDAVPHYGIGYGLLRYLYAP Mvan_3123|M.vanbaalenii_PYR-1 WFTTIHPVVLT-AARQG-SATQALGDVRETLKAVPHYGIGYGLLRYLYAP MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 MQGAFASRFNVPAQFLAPIPDGIGAVEAATIPAAALTVRLAFDWAQLKPG TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 TGRVLGAQRTPDIHFRYAGVIPELPSG---DAPVQFDSDMTLPVREPIPG Rv2935|M.tuberculosis_H37Rv TGRVLGAQRTPDIHFRYAGVIPELPSG---DAPVQFDSDMTLPVREPIPG MLBr_02353|M.leprae_Br4923 TGRVFSAQRTPDIHFRYVGVVPEPPSV---DATVQFDSDMTIPVQEPVPG MMAR_1772|M.marinum_M TGRVLGAQRTPDIHFRYAGTIPELPPV---DAPVQFDSDLAMPVREPLPG MUL_2015|M.ulcerans_Agy99 TGRVLGAQRTPDIHFRYAGTIPELPPV---DAPVQFDSDLAMPVREPLPG Mflv_3390|M.gilvum_PYR-GCK TARLLGDGRPADILFSHVGTIPDAPADQPDDAPVRFDPDTAMPIRDALPG Mvan_3123|M.vanbaalenii_PYR-1 TARVLGASRPADILFSHIGTIPEVPAEQPDDAPVRFDADTAMPIRDALPG MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 DKVLIHAASGGVGLAAIQMAQQSGAEVFATASTFKRSTLRRLGVKYVYDS TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 MGHAIELRVYRFGGSLHLDWWYDTRRIPAATAEALERTFPLALSALIQEA Rv2935|M.tuberculosis_H37Rv MGHAIELRVYRFGGSLHLDWWYDTRRIPAATAEALERTFPLALSALIQEA MLBr_02353|M.leprae_Br4923 MGHAIELRTYRFGGSLHLDWWYDIRRIPQVTAEALAQSFPVTLSKLIQEG MMAR_1772|M.marinum_M LGHAVEIRAYRSGSSLHVDWWYDTRRITAETATALARSFPTALSELIQES MUL_2015|M.ulcerans_Agy99 LGHAVEIRAYRSGSSLHVDWWYDTRRITAETATALARSFPTALSELIQES Mflv_3390|M.gilvum_PYR-GCK LGHALEVRIYRTGGELHLDWWYDIRRLGPTDVESFSRQYSAAVLDISREA Mvan_3123|M.vanbaalenii_PYR-1 LGHAVELRVYRAAGVLHLDWWYDNRRLGPTDVESFARQYSEALLDVTRDA MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 RTTDFADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 IAAEHTEHDDSEIVGEPEAGALVDLSSMDAG------------------- Rv2935|M.tuberculosis_H37Rv IAAEHTEHDDSEIVGEPEAGALVDLSSMDAG------------------- MLBr_02353|M.leprae_Br4923 IATQKDAHDESEMAGAPQAGVLVDLSTLDAG------------------- MMAR_1772|M.marinum_M IAAEQEERDEDEKVGVIEAGALVDLSSLDAG------------------- MUL_2015|M.ulcerans_Agy99 IAAEQEERDEDEKVGVIEAGALVDLPSLDAG------------------- Mflv_3390|M.gilvum_PYR-GCK LAEEDTDAAGDELA-------LVDLS------------------------ Mvan_3123|M.vanbaalenii_PYR-1 LAEEDTDAAGDELA-------LVDLS------------------------ MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 DIWSHEQMAEARPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWT TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 PLPAEIYPITEARSAFRRMQQARHIGKIVLQVPKPLQPQQDRSYLITGGL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 GAIGLHTAAYLAQLGAGDIVLTSRRDPDESAQRAIDEITERHKCRIHTYA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 ADVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPERFRTTL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 APKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAMLDGL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 VAKRRAQGLVATGINFGPWGQGGMASSEAATANITAQGLIPLDPSAALHA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LAEVIANGSGQATVLKANWQRAAKVLGSARPPILDLVLPSAAGEATGDSE TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LLKQLMEIPIPQRAGFVTEFLQREVQNFLRLASPPAASSRFLDLGTDSLM TH_4458|M.thermoresistible__bu -------------------------------------------------- Mb2960|M.bovis_AF2122/97 -------------------------------------------------- Rv2935|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- MMAR_1772|M.marinum_M -------------------------------------------------- MUL_2015|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3107|M.avium_104 ------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 AIELRNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDAEAPETA TH_4458|M.thermoresistible__bu ------------------------------------------------- Mb2960|M.bovis_AF2122/97 ------------------------------------------------- Rv2935|M.tuberculosis_H37Rv ------------------------------------------------- MLBr_02353|M.leprae_Br4923 ------------------------------------------------- MMAR_1772|M.marinum_M ------------------------------------------------- MUL_2015|M.ulcerans_Agy99 ------------------------------------------------- Mflv_3390|M.gilvum_PYR-GCK ------------------------------------------------- Mvan_3123|M.vanbaalenii_PYR-1 ------------------------------------------------- MAB_2256|M.abscessus_ATCC_1997 -------------------------------------------------