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SLVIATPQLLATAALDLASIGSQVSAANAAAAMPTTEVVAAAADEVSAAIAGLFGAHARQYQALSVQVAA FHEQFVQALTAAAGRYASTEAAVERSLLGAVNAPTEALLGRPLIGNGADGTAPGQPGAAGGLLFGNGGNG AAGGFGQTGGSGGAAGLIGNGGNGGAGGTGAAGGAGGNGGWLWGNGGNGGVGGTSVAAGIGGAGGNGGNA GLFGHGGAGGTGGAGLAGANGVNPTPGPAASTGDSPADVSGIGDQTGGDGGTGGHGTAGTPTGGTGGDGA TATAGSGKATGGAGGDGGTAAAGGGGGNGGDGGVAQGDIASAFGGDGGNGSDGVAAGSGGGSGGAGGGAF VHIATATSTGGSGGFGGNGAASAASGADGGAGGAGGNGGAGGLLFGDGGNGGAGGAGGIGGDGATGGPGG SGGNAGIARFDSPDPEAEPDVVGGKGGDGGKGGSGLGVGGAGGTGGAGGNGGAGGLLFGNGGNGGNAGAG GDGGAGVAGGVGGNGGGGGTATFHEDPVAGVWAVGGVGGDGGSGGSSLGVGGVGGAGGVGGKGGASGMLI GNGGNGGSGGVGGAGGVGGAGGDGGNGGSGGNASTFGDENSIGGAGGTGGNGGNGANGGNGGAGGIAGGA GGSGGFLSGAAGVSGADGIGGAGGAGGAGGAGGSGGEAGAGGLTNGPGSPGVSGTEGMAGAPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2487c | PE_PGRS42 | - | 100% (694) | PE-PGRS FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv2490c | PE_PGRS43 | 0.0 | 50.12% (824) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv2853 | PE_PGRS48 | 0.0 | 57.69% (624) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2878 | PE_PGRS48 | 0.0 | 57.85% (624) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-138 | 48.25% (628) | triple helix repeat-containing collagen |
| M. leprae Br4923 | MLBr_01183 | - | 1e-14 | 44.09% (93) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 7e-47 | 29.98% (557) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_5135 | - | 0.0 | 56.17% (705) | PE-PGRS family protein, PE_PGRS15 |
| M. avium 104 | MAV_4827 | - | 4e-22 | 39.77% (171) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-110 | 37.78% (818) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 5e-44 | 39.52% (334) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4367 | - | 1e-169 | 44.15% (838) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-133 | 47.00% (649) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
Rv2487c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5135|M.marinum_M --------------------------------------------------
MUL_4367|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
Rv2487c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5135|M.marinum_M --------------------------------------------------
MUL_4367|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
Rv2487c|M.tuberculosis_H37Rv ---------------------------------------MSLVI-ATPQL
MLBr_01183|M.leprae_Br4923 ---------------------------------------MPLFLNAEPQA
Mb2878|M.bovis_AF2122/97 ----------------------------------------MLYVVASPDL
MMAR_5135|M.marinum_M ----------------------------------------MSYVVAASDL
MUL_4367|M.ulcerans_Agy99 ----------------------------------------MSFVSVGPGL
TH_3810|M.thermoresistible__bu -----------------------------------------VDGDGGSGG
MAB_4284c|M.abscessus_ATCC_199 --------------------------------MSIIDFILNLFRDPVEAA
MAV_4827|M.avium_104 -------------------------------------MNIVLGVSMAPSS
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
Rv2487c|M.tuberculosis_H37Rv ------------------------------------------LATAALDL
MLBr_01183|M.leprae_Br4923 ------------------------------------------LTAAANTL
Mb2878|M.bovis_AF2122/97 ------------------------------------------MTAAATNL
MMAR_5135|M.marinum_M ------------------------------------------LASTATEL
MUL_4367|M.ulcerans_Agy99 ------------------------------------------LEAAARDL
TH_3810|M.thermoresistible__bu ------------------------------------------RTGLFSKL
MAB_4284c|M.abscessus_ATCC_199 S----------------------------------------YVADPEAAL
MAV_4827|M.avium_104 ----------------------------------------IQMVVLEGEY
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
Rv2487c|M.tuberculosis_H37Rv AS----------------------IGSQVS-----------AANAAAAMP
MLBr_01183|M.leprae_Br4923 EG----------------------LSAATV-----------ASNAAAAQL
Mb2878|M.bovis_AF2122/97 AE----------------------IGSAIS-----------TANGAAALP
MMAR_5135|M.marinum_M AR----------------------IDAALN-----------TANAAAVLP
MUL_4367|M.ulcerans_Agy99 AG----------------------LGAGLR-----------EANLAAAGA
TH_3810|M.thermoresistible__bu SR---------------------------------------GGDGGDGGL
MAB_4284c|M.abscessus_ATCC_199 AN----------------------AGLSAVS----------AAQVGAVMP
MAV_4827|M.avium_104 AD-----------------------GATVEEDAIDVT----GADDAATAS
:
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
Rv2487c|M.tuberculosis_H37Rv TT-------EVVAAAADEVSAAIAGLFGAHARQYQALSVQVAAFHEQFVQ
MLBr_01183|M.leprae_Br4923 TT-------EIAPPAADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQ
Mb2878|M.bovis_AF2122/97 TV-------EVVAAAADEVSTQIAALFGAHARSYQTLSTQAAAFHSRFVQ
MMAR_5135|M.marinum_M TT-------VLQAAGADEVSAAVAALFSSHARAYQALSVQAGQFHQWFTQ
MUL_4367|M.ulcerans_Agy99 TV-------GVLPAAGDEVSAAIAELFGGFGREYQAMGARVALLHDDFVR
TH_3810|M.thermoresistible__bu GG-----------NGGHGGGTGIISLLSLAGNGGNGGNGYRTTDNNALDG
MAB_4284c|M.abscessus_ATCC_199 VVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLS
MAV_4827|M.avium_104 APDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDN
. .
Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
Rv2487c|M.tuberculosis_H37Rv ALTAAAGRYASTEAAVERSLLG-------AVNAPTEALLGRPLIGNGADG
MLBr_01183|M.leprae_Br4923 SLLTSSSAYAGTETANHDSL------------------------------
Mb2878|M.bovis_AF2122/97 ALTTAAASYASVEAANASPLQV----ALDVINAPAQTLLGRPLIGNGADG
MMAR_5135|M.marinum_M TLSGAGLSYASAEAANVSPLQVLERDVLGLVNAPTQALLGRPIIGNGADG
MUL_4367|M.ulcerans_Agy99 ALTAGGSAYGQAEALNMWPLQELEQQALGVVNAPSMALFGRPSIGNGVDG
TH_3810|M.thermoresistible__bu GHGGNGGNVGFFSLFNLGGAGG----------------------------
MAB_4284c|M.abscessus_ATCC_199 PRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQ
MAV_4827|M.avium_104 VMLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPD
Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
Rv2487c|M.tuberculosis_H37Rv TA---PGQPGAAGGLLFGNGGNGAAGGFGQTGGSG---------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 ST---PGQAGGPGGLLYGNGGNGAAGGPNQAGGAG---------------
MMAR_5135|M.marinum_M APG--SGANGADGGILIGNGGTGGSGAPGQNGGAG---------------
MUL_4367|M.ulcerans_Agy99 VAG--TGQAGGAGGILWGNGGNGGLGAAGANGGAG---------------
TH_3810|M.thermoresistible__bu ----WGGSGVDGVDVVGGNPDGGTPGAHGESHTPG---------------
MAB_4284c|M.abscessus_ATCC_199 FGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNG--------------D
MAV_4827|M.avium_104 VYK--QQIRAESYGDAAGQLSAMVAGLEKLESLPG---------------
Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----------------
Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----------------
MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
Rv2487c|M.tuberculosis_H37Rv -GAAGLIGNGGNGGAGGTGAA------GGAGGNGG------------WLW
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 -GNAGLIGNGGAGGAGGVGAV------GGNGGTGG------------LLF
MMAR_5135|M.marinum_M -GNAGLLGSGGTGGVGGAGAT------GGTGGTGG------------LLW
MUL_4367|M.ulcerans_Agy99 -GSAGLIGTGGVGGAGGVGAAGMTGGSGGAGGGGG------------WLW
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VRDSNIINADHGSNVGVDQSQ------TRVGGDYT---------------
MAV_4827|M.avium_104 --GLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEPE------------TAL
Mflv_5091|M.gilvum_PYR-GCK AVGAAGAAG-----------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 AIGTAGVAG-----------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGST------------------------------------
Rv2487c|M.tuberculosis_H37Rv GNGGNGGVGGT---------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 GNGGAGGQGGL---------------------------------------
MMAR_5135|M.marinum_M GNGGIGGQGGT---------------------------------------
MUL_4367|M.ulcerans_Agy99 GAGGSGGAAGAGGSGGSGGWLWGNAGQTAGAGVGGAGGAGGAGDAGDQGV
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NVSGHGSADIDKS-------------------------------------
MAV_4827|M.avium_104 ARGAALAAANAPLFAS----------------------------------
Mflv_5091|M.gilvum_PYR-GCK ------------TVGTAGATGGTG---------------TGANGGAGGVG
Mvan_1264|M.vanbaalenii_PYR-1 ------------AAGTAGATGGTG---------------VGGNGGAGQAG
MSMEG_0868|M.smegmatis_MC2_155 -----------TAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHSTGT
Rv2487c|M.tuberculosis_H37Rv -----------SVA---AGIGGAG-----------------GNGGNAGLF
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 -----------GLAGINGGSGGQG-----------------GHGGNAILF
MMAR_5135|M.marinum_M -----------AMAGVNGGSPGHG-----------------GNGGNAFLF
MUL_4367|M.ulcerans_Agy99 SGVAPGEAGAVGFAGGAGGAGGAG-----------------GNGVGGGVN
TH_3810|M.thermoresistible__bu --------------------------------------------VYTDRQ
MAB_4284c|M.abscessus_ATCC_199 ----------VTVVDDHSQRNTTN----------------INDSFNTDRS
MAV_4827|M.avium_104 ----------STAALAYAQDPGTG---------------AVDQYSLPDYL
Mflv_5091|M.gilvum_PYR-GCK GVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGGQ--GT
Mvan_1264|M.vanbaalenii_PYR-1 GIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGGQ--GT
MSMEG_0868|M.smegmatis_MC2_155 GIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIYSGA
Rv2487c|M.tuberculosis_H37Rv GHGGAGGTG--------------GAGLAGANGVNPTPGPAASTGDSPADV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 GQGGAGGPG--------------GTGAMGVAGTNPTPIGTAAPGSDGVNQ
MMAR_5135|M.marinum_M GDGGTGGQG--------------GTGLAGADGVNPTPTGTAGTGAAGGNV
MUL_4367|M.ulcerans_Agy99 GAGGAGGAG--------------GVGGGGGAGASGVGAGVAG-GDGGTGG
TH_3810|M.thermoresistible__bu GEDGEDGTG---------------TGIGGRGGNGGSSSGTHPMAEDGEHV
MAB_4284c|M.abscessus_ATCC_199 TNIGSGNTTN----------TEIGSHNQANIGTSTSAGGSAAVGGN-AGL
MAV_4827|M.avium_104 YVPVDPEPGD----------DELAYSAVGEEDAESPTVVIEKLFLPEDSE
Mflv_5091|M.gilvum_PYR-GCK AGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG-------------L
Mvan_1264|M.vanbaalenii_PYR-1 EGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG-------------L
MSMEG_0868|M.smegmatis_MC2_155 DGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTAKAG
Rv2487c|M.tuberculosis_H37Rv SGIGDQTGGDGGTGGHGTAG--TPTGG----TGGDGATATA-GSGKATGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 IGNGGNTDLTGGAGGDGNAGSTTVNGG----NGGTGGAARN-SSGGTGNS
MMAR_5135|M.marinum_M SGNG---PLTGGNGDTGDTGGTGETGG----TGGAGGSATA-SSGSATGG
MUL_4367|M.ulcerans_Agy99 AGGAAGVGGAAGTGGTGGAAGVAGTGG----DGGDGGAGGAGSDASLAGQ
TH_3810|M.thermoresistible__bu KALDGRPGLDGGNGSHGGNGGHGGRGG--------------------FLG
MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAGNAGLAGN---------------------AG
MAV_4827|M.avium_104 PRRRPVLLVGSGLAVVGISAVLALEIALAIGIRTTGTVALQPTPNQHLIV
Mflv_5091|M.gilvum_PYR-GCK QGGKGGDGGAGGKGGDADSMGS------------------AGATGGKGGN
Mvan_1264|M.vanbaalenii_PYR-1 QGGQGGDGGTGGTGGDATSMGE------------------AGATGGKGGN
MSMEG_0868|M.smegmatis_MC2_155 HGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAVGGN
Rv2487c|M.tuberculosis_H37Rv AGGDGGTAAAGGGGGNGGDGGVAQGDIASAFGGDGGNGSDGVAAGSGGGS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 FGGAGGAGGDGANGGDGGAGGEALT--EGGATAVSGAGGKGGNAEASGGA
MMAR_5135|M.marinum_M KGGAGGDPGGGANGGAGGAGGDAES--FSG-QAHGGAGGDGSQGGIPGGS
MUL_4367|M.ulcerans_Agy99 AGFAGGSGGAGGVGGSAGAGGVNGSGGDGGAGAAGGAGGASATVAGSGGV
TH_3810|M.thermoresistible__bu IGGSGGWGGHGGNGGD---------------------------TDADGGN
MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAGLAGNAG----------------LAGNAGLAGN
MAV_4827|M.avium_104 PTEQAPAPPPVQASAPQPKISVPEP--------VAAPKPLSPPVAAPLPA
Mflv_5091|M.gilvum_PYR-GCK GGNGGRGGLFG---------------KGGNAGNGAD--------------
Mvan_1264|M.vanbaalenii_PYR-1 GGNGGRGSLFG---------------RGGNAGNGGN--------------
MSMEG_0868|M.smegmatis_MC2_155 GGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGT
Rv2487c|M.tuberculosis_H37Rv GGAGGGAFVHIA----------TATSTGGSGGFGGNG----------AAS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 GGNGGKGGFAQA----------TTSVTGGNGGNGGNG----------HDS
MMAR_5135|M.marinum_M GGAGGDGGKATG----------LASGIGGDGGDGGRG----------FAT
MUL_4367|M.ulcerans_Agy99 GGDGGAGGAAGGGV--------GAASLGGDGGHAGAGGAGGEGLSGGFNT
TH_3810|M.thermoresistible__bu GGDGGN--------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGN------------AGLAGNAGLAGN--------------
MAV_4827|M.avium_104 APPPAAPPLPEAP-----------PIPAAPPVVPVP--------------
Mflv_5091|M.gilvum_PYR-GCK --------GGTGGAGGAGGTGG-TGGAGGTGG-----------------T
Mvan_1264|M.vanbaalenii_PYR-1 --------GGTGGNGGNGGTGG-TGGNGGTGG-----------------T
MSMEG_0868|M.smegmatis_MC2_155 TIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQTDT
Rv2487c|M.tuberculosis_H37Rv AASG--ADGGAGGAGGNGGAGGLLFGDGGNGG-----------------A
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 NAPG--GAGGSGGVGGDGGRGGLLAGNGGTGG-----------------A
MMAR_5135|M.marinum_M DVSG--GTAGGGGTGGDGGRGGLLIGSGGNGG-----------------T
MUL_4367|M.ulcerans_Agy99 GAAG--GIGGAGGAGGTGGDSGGVGGVNGDGG-----------------A
TH_3810|M.thermoresistible__bu --------GGSAGRGGTGGLRGVFGINGGNGR------------------
MAB_4284c|M.abscessus_ATCC_199 --------AGLAGNAGLAGNAGLAGNAGLAGNAG---------------L
MAV_4827|M.avium_104 --------VVVPPVPVPVPVRIPVPDPVSPPQ-----------------L
Mflv_5091|M.gilvum_PYR-GCK GGTGGIGGAGSTGGTGG-TGGTGGTGGTGGTG-GTGGTGGTGG-------
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGIGGAGSTGGTGG-TGGTGGTGGTGGTG-GTGGTGGTGG-------
MSMEG_0868|M.smegmatis_MC2_155 GGNGGRGGDGGTFVNAG-ANGNGGAGGAGGVSEGEGGTGGHGG-------
Rv2487c|M.tuberculosis_H37Rv GGAGGIGGDGAT-------GGPGGSGGNAGIARFDSPDPEAE--------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 GGNGGTGGAGAP-------GGAGGAGGKA----DIANSLGDN--------
MMAR_5135|M.marinum_M GGTGGTGGTGAA-------AGVGGIGGDG----GDATAA-----------
MUL_4367|M.ulcerans_Agy99 GGGGGRGGDGGSSTSTSGVGGAGGAGGNGGNAGFGVSAGGTGGSAGDGGA
TH_3810|M.thermoresistible__bu ---AGLGGRGX---------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAAVAGNAAVAGNAAVAGNAAVGGVLNTGVSGAIG-------
MAV_4827|M.avium_104 LAPPRLSVPQPVQPPVRVPQPPSPPQVGGTVPQSPPQHQTPPG-------
Mflv_5091|M.gilvum_PYR-GCK ------------TGGKGGTGGTGGAGGTG----GDGGTGGTGGTGGTG--
Mvan_1264|M.vanbaalenii_PYR-1 ------------TGGKGGTGGTGGDGGTG----GTGGTGGTGGTGGTG--
MSMEG_0868|M.smegmatis_MC2_155 ------------DGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGT
Rv2487c|M.tuberculosis_H37Rv ------------PDVVGGKGGDGGKGGSGLGVGGAGGTGGAGGNGGAGGL
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 ------------ATVTGGNGGTGGDGGSALGTGGAGGAGGLGGHGGAGGL
MMAR_5135|M.marinum_M ------------SSATGGHGGDGGDSDPSVGTGGNGGTGGNGGNGGAASL
MUL_4367|M.ulcerans_Agy99 GGGAGGVDGVGGASGNGGAAGAGGAGGSGIGAGIDGGAGGAGGTGGAAGF
TH_3810|M.thermoresistible__bu -------------XXXGGGVGAAVRSGNGVFSGGGGTPSAGFGVPTTIQF
MAB_4284c|M.abscessus_ATCC_199 -----------GSSHVGGAINESLGGSGSVGGSTAVGGGAHTGVGGGVST
MAV_4827|M.avium_104 ------------EGTPPKPDGPGNYGGGHVPTPGAGGSGGSGGGHVP---
Mflv_5091|M.gilvum_PYR-GCK -------GTGGTGGTGGAG-----------DGTGGTGGTGG---------
Mvan_1264|M.vanbaalenii_PYR-1 -------GTGGTGGTGGAG-----------DGLGGTGGTGG---------
MSMEG_0868|M.smegmatis_MC2_155 YVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNG-------
Rv2487c|M.tuberculosis_H37Rv --------LFGNGGNGGNA------------GAGGDGGAG----------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 --------LIGNGGAGGAG------------GLGGAGGAG----------
MMAR_5135|M.marinum_M --------LFGNGGSGGDG------------GVGGTGGTG----------
MUL_4367|M.ulcerans_Agy99 PGGGGTTGAWGTGGAGGAG------------GAGGAGDHGGVGVNPGDSG
TH_3810|M.thermoresistible__bu P-------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 G--------VGVGSHVGGG---------ISESLGGSGSVGG---------
MAV_4827|M.avium_104 --------TPGAGGSGGSG--------------GGHVPTPG---------
Mflv_5091|M.gilvum_PYR-GCK ----TGGQGGQGGQGG-----------------TGGTGGQGG-LGGGGGT
Mvan_1264|M.vanbaalenii_PYR-1 ----TGGFGGQGGQGG-----------------TGGTGGQGG-LGGVGGT
MSMEG_0868|M.smegmatis_MC2_155 --DADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGT
Rv2487c|M.tuberculosis_H37Rv ---VAGGVGGNGGGGGTATFH----------EDPVAGVWAVGGVGGDGGS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 ---GAGGEGGAGGAGG--------------------EAIP---------G
MMAR_5135|M.marinum_M ---GAGGSGAGGGVGG--------------------DGSSRGGIGGNGGS
MUL_4367|M.ulcerans_Agy99 TAGWAGGAGGAGGAGGSAAFNG---------VNGAGGAGGNGGAGGGGGA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --STAVGGGAHTGVGG--------------------GVSTGVGVGSHVGG
MAV_4827|M.avium_104 ----TGGPGGTGGSGG----------------------------------
Mflv_5091|M.gilvum_PYR-GCK G-----------------------GQGGTGGTGGQGGTGGTGGTGGTG--
Mvan_1264|M.vanbaalenii_PYR-1 G-----------------------GTGGTGGTGGQGGTGGTGGTGGTG--
MSMEG_0868|M.smegmatis_MC2_155 GGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPS
Rv2487c|M.tuberculosis_H37Rv GGSS----------------------LGVGGVGGAGGVGGKGGASGM---
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 GAST----------------------NSAGGDGGAGGTGG----------
MMAR_5135|M.marinum_M GANS----------------------MAIGGEGGVGGRGGDAGTSGL---
MUL_4367|M.ulcerans_Agy99 GASG----------------------IGAGVAGGDGGTGGTGGAAGTG--
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GISES-----------------------LGGSGSVGGSTAVGGGAHTG--
MAV_4827|M.avium_104 ---------------------------GHVPTPGAGTPGGSGGGHLPFP-
Mflv_5091|M.gilvum_PYR-GCK ------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG
Mvan_1264|M.vanbaalenii_PYR-1 ------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG
MSMEG_0868|M.smegmatis_MC2_155 AVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDG
Rv2487c|M.tuberculosis_H37Rv -------LIGNGGNGGSGGVGGAGGVGGAGGDGGNGGSGGNASTFGDENS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 ----------NGGDGGAGGAPGLGGAGGAG--------------------
MMAR_5135|M.marinum_M -------LIGNGGDGGSGGAGGTGGTGGAGGAGAAGGAGGNGS---TQIA
MUL_4367|M.ulcerans_Agy99 ------GAAGTGGTGGAAGAAGSAGDGGAGGAGGAGDDGSAGVVSGDPGT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------VGGGVNTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHT
MAV_4827|M.avium_104 ---------GAGSTPGGSGGGHLPTPGAGTPGGGLGGFG-----------
Mflv_5091|M.gilvum_PYR-GCK --QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGATGAQGAT
Mvan_1264|M.vanbaalenii_PYR-1 --QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGATGAQGAT
MSMEG_0868|M.smegmatis_MC2_155 GKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGN
Rv2487c|M.tuberculosis_H37Rv IGGAGGTGGNGGNGANGGNGGAGGIAGGAGGSGGFLSGAAGVS-------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 ---------------------------------GWLIGQSGST-------
MMAR_5135|M.marinum_M FGGDGGNGGDGGDGAQGGEGGATGSVGGIGSQGGILFSHAGAD-------
MUL_4367|M.ulcerans_Agy99 AGKAGGAGGAGGVGGNGVAGGVNGSGGAGGAGGAGGTGGAGASGVPASVD
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SAINDALGGSGSVG------------GSTAVGGGAHTSAINESMN-----
MAV_4827|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK G------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG-----------T
Mvan_1264|M.vanbaalenii_PYR-1 G------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG-----------T
MSMEG_0868|M.smegmatis_MC2_155 GGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAI
Rv2487c|M.tuberculosis_H37Rv ----------------------GADGIGGAGGAGGAG-------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 ----------------------GGGGAGGAGGAGGAG-------------
MMAR_5135|M.marinum_M ----------------------GSTGAPGAGGAGGAG-------------
MUL_4367|M.ulcerans_Agy99 GGDGGAGGAGGAAGTGGSGGSAGNTGAGGAGGAGGAGGSAASTGV--NGD
TH_3810|M.thermoresistible__bu ----------------------AGSCTSRAVSREGIMP------------
MAB_4284c|M.abscessus_ATCC_199 ----------------------SSINASHSSSMNESFG------------
MAV_4827|M.avium_104 ----------------------GGHAPAPGGGLGGGGG------------
Mflv_5091|M.gilvum_PYR-GCK TGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------------
Mvan_1264|M.vanbaalenii_PYR-1 TGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------------
MSMEG_0868|M.smegmatis_MC2_155 TDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKI---------AN
Rv2487c|M.tuberculosis_H37Rv -GAGGSGGEAGAGGLTNGP-GSPGVSGTEGMAGAPG--------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 -GAGGSGGAGGHGDTTSGKNGSSGTAGFDGNPGQPG--------------
MMAR_5135|M.marinum_M -GAAGGFGAGGSG-ATAGADGKAGTAGTAGATGPHG--------------
MUL_4367|M.ulcerans_Agy99 GGAGGAGGVGGLGGDSAATAGGGGAGGDGGKGGAGGAGVNGVGGGDGGKG
TH_3810|M.thermoresistible__bu -SSRAASARAGAACASSTSRSRRSFCCSRA--------------------
MAB_4284c|M.abscessus_ATCC_199 -SSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH------------
MAV_4827|M.avium_104 -HAPAPGGGLGGFGGGHSGGGLGGLGGGHK--------------------
Mflv_5091|M.gilvum_PYR-GCK ---AAGEDGDAGSGGSG-INGGAGGAGG----------------------
Mvan_1264|M.vanbaalenii_PYR-1 ---AAGDAGDPGSEAVD-INGGAGGAGG----------------------
MSMEG_0868|M.smegmatis_MC2_155 SSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQT-----------
Rv2487c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5135|M.marinum_M --------------------------------------------------
MUL_4367|M.ulcerans_Agy99 GTGGAGGAGGAGSDGIIPSNGGLGGNGGNGGNGGQAFGDGVGGAGGIGGK
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -----------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGS
Mvan_1264|M.vanbaalenii_PYR-1 -----------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGS
MSMEG_0868|M.smegmatis_MC2_155 -----------ADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGT
Rv2487c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5135|M.marinum_M --------------------------------------------------
MUL_4367|M.ulcerans_Agy99 GGNAAIGTIVINGGVGGAGGSGGLGGATEDGVGGVGCAGGAGGNGGRGDM
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD----------------
Mvan_1264|M.vanbaalenii_PYR-1 GTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD-----------------
MSMEG_0868|M.smegmatis_MC2_155 TAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP----------------
Rv2487c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mb2878|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5135|M.marinum_M --------------------------------------------------
MUL_4367|M.ulcerans_Agy99 LFTVGGSGGTGGDGGGGGSASGSGTGGSGGTGGVGGIGGDGKLGGFGGDG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------------------
Rv2487c|M.tuberculosis_H37Rv ---------------------------------------------
MLBr_01183|M.leprae_Br4923 ---------------------------------------------
Mb2878|M.bovis_AF2122/97 ---------------------------------------------
MMAR_5135|M.marinum_M ---------------------------------------------
MUL_4367|M.ulcerans_Agy99 GDGGDGGFGVIGGQGGGGGFGGLGGTGAGGAPSDKGINGEPGNPG
TH_3810|M.thermoresistible__bu ---------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------------
MAV_4827|M.avium_104 ---------------------------------------------