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VSYVVAASDLLASTATELARIDAALNTANAAAVLPTTVLQAAGADEVSAAVAALFSSHARAYQALSVQAG QFHQWFTQTLSGAGLSYASAEAANVSPLQVLERDVLGLVNAPTQALLGRPIIGNGADGAPGSGANGADGG ILIGNGGTGGSGAPGQNGGAGGNAGLLGSGGTGGVGGAGATGGTGGTGGLLWGNGGIGGQGGTAMAGVNG GSPGHGGNGGNAFLFGDGGTGGQGGTGLAGADGVNPTPTGTAGTGAAGGNVSGNGPLTGGNGDTGDTGGT GETGGTGGAGGSATASSGSATGGKGGAGGDPGGGANGGAGGAGGDAESFSGQAHGGAGGDGSQGGIPGGS GGAGGDGGKATGLASGIGGDGGDGGRGFATDVSGGTAGGGGTGGDGGRGGLLIGSGGNGGTGGTGGTGGT GAAAGVGGIGGDGGDATAASSATGGHGGDGGDSDPSVGTGGNGGTGGNGGNGGAASLLFGNGGSGGDGGV GGTGGTGGAGGSGAGGGVGGDGSSRGGIGGNGGSGANSMAIGGEGGVGGRGGDAGTSGLLIGNGGDGGSG GAGGTGGTGGAGGAGAAGGAGGNGSTQIAFGGDGGNGGDGGDGAQGGEGGATGSVGGIGSQGGILFSHAG ADGSTGAPGAGGAGGAGGAAGGFGAGGSGATAGADGKAGTAGTAGATGPHG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5135 | - | - | 100% (681) | PE-PGRS family protein, PE_PGRS15 |
| M. marinum M | MMAR_2492 | - | 0.0 | 56.04% (646) | PE-PGRS family protein, PE_PGRS15_2 |
| M. marinum M | MMAR_2490 | - | 0.0 | 54.87% (636) | PE-PGRS family protein, PE_PGRS15_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0896c | PE_PGRS15 | 0.0 | 58.06% (620) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-141 | 47.90% (620) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv2487c | PE_PGRS42 | 0.0 | 56.03% (705) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01556 | infB | 5e-11 | 29.67% (209) | translation initiation factor IF-2 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 4e-47 | 27.44% (707) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_4827 | - | 1e-22 | 43.03% (165) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-109 | 40.27% (750) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 2e-44 | 41.20% (301) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0572 | - | 1e-179 | 48.15% (785) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-132 | 48.11% (555) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MMAR_5135|M.marinum_M --------------------------------------------------
Rv2487c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0896c|M.bovis_AF2122/97 --------------------------------------------------
MUL_0572|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MMAR_5135|M.marinum_M --------------------------------------------------
Rv2487c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0896c|M.bovis_AF2122/97 --------------------------------------------------
MUL_0572|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MMAR_5135|M.marinum_M ------------------------------------------MSYVVAAS
Rv2487c|M.tuberculosis_H37Rv ------------------------------------------MSLVIATP
Mb0896c|M.bovis_AF2122/97 ------------------------------------------MSYVLATP
MUL_0572|M.ulcerans_Agy99 ------------------------------------------MSYVVAIP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------MSIIDFILNLF
MAV_4827|M.avium_104 ------------------------------------------MNIVLGVS
MLBr_01556|M.leprae_Br4923 -----------------------------------MAGKARVHELAK---
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MMAR_5135|M.marinum_M ----------------------------------------DLLASTATEL
Rv2487c|M.tuberculosis_H37Rv ----------------------------------------QLLATAALDL
Mb0896c|M.bovis_AF2122/97 ----------------------------------------EMVAAAANNL
MUL_0572|M.ulcerans_Agy99 ----------------------------------------DMLASAAADV
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 R---------------------------------------DPVEAASYVA
MAV_4827|M.avium_104 ---------------------------------------MAPSSIQMVVL
MLBr_01556|M.leprae_Br4923 ----------------------------------------ELGVTSKEVL
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MMAR_5135|M.marinum_M AR----------------------IDAALN-----------TANAAAVLP
Rv2487c|M.tuberculosis_H37Rv AS----------------------IGSQVS-----------AANAAAAMP
Mb0896c|M.bovis_AF2122/97 AQ----------------------IGSTLS-----------AANAAALAP
MUL_0572|M.ulcerans_Agy99 AG----------------------IGSSVG-----------AANTAAVGA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 DP-----------------------EAALAN----------AGLSAVSAA
MAV_4827|M.avium_104 EG-----------------------EYADG-----------ATVEEDAID
MLBr_01556|M.leprae_Br4923 AR----------------LNEQGE--------------FVKSASSTVEAP
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
MMAR_5135|M.marinum_M TT-------VLQAAGADEVSAAVAALFSSHARAYQALSVQAGQFHQWFTQ
Rv2487c|M.tuberculosis_H37Rv TT-------EVVAAAADEVSAAIAGLFGAHARQYQALSVQVAAFHEQFVQ
Mb0896c|M.bovis_AF2122/97 TT-------GVLAAGADEVSAAVASLFSGHAQAYQTLGTQAAAFHERFIQ
MUL_0572|M.ulcerans_Agy99 TT-------GVMAAADDEVSVAIAALFSGHGQAYQAISAQAAAFHDQFLR
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 QVG-------AVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAA
MAV_4827|M.avium_104 VTG---ADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEA
MLBr_01556|M.leprae_Br4923 VARRLRESFGGIKPAADKGAEQVATKAQAKRLGESLDQTLDRALDKAVAG
Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
MMAR_5135|M.marinum_M ------------TLSGAGLSYASAEAANVSPLQVLERDVLGLVNAPTQAL
Rv2487c|M.tuberculosis_H37Rv ------------ALTAAAGRYASTEAA-------VERSLLGAVNAPTEAL
Mb0896c|M.bovis_AF2122/97 ------------ALSTAAGAYGSAEAANAS----PLQQALNVINAPTQTL
MUL_0572|M.ulcerans_Agy99 ------------ALTGAGGAYAAAEAANASPLQAAEQEVLAVINAPTNAL
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 QPDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSF
MAV_4827|M.avium_104 A-----------ALRDALAARRIDNVMLVSAFLAAAALAQNVGGAMGYER
MLBr_01556|M.leprae_Br4923 NG------ATTAAPVQVDHSAAVVPIVAGEGPSTAHREELAPPAGQPSEQ
Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
MMAR_5135|M.marinum_M LGRPIIG-----------NGADGAPGSGANGADGG-------------IL
Rv2487c|M.tuberculosis_H37Rv LGRPLIG-----------NGADGT-APGQPGAAGG-------------LL
Mb0896c|M.bovis_AF2122/97 LGRPLIG-----------NGTNGAPGTGQAGGPGG-------------LL
MUL_0572|M.ulcerans_Agy99 LGRPLIG-----------NGTDGLAGTGAAGGAGG-------------LL
TH_3810|M.thermoresistible__bu --------------------VDGDGGSGGRTGLFS--------------K
MAB_4284c|M.abscessus_ATCC_199 NRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSG-----------PIA
MAV_4827|M.avium_104 TAVLLVEP-------------DTATLAVVETSDGS-------------IP
MLBr_01556|M.leprae_Br4923 PGVPLPGQ----------QGTPAAPHPGHPGMPTGPHPG------PAPKP
. .
Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG----NAGLPGKAGDAGGAG----AVGAAG----
Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG----NAGLPGAAGAAGGAG----AIGTAG----
MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQ--STAAGPGKGGGGGGGGGGAILIGANGGTVD
MMAR_5135|M.marinum_M IGNGGTGGSGAPGQNGG----AGGNAGLLGSGGTGG-----VGGAG----
Rv2487c|M.tuberculosis_H37Rv FGNGGNGAAGGFGQTGG----SGGAAGLIGNGGNGG-----AGGTG----
Mb0896c|M.bovis_AF2122/97 YGNGGNGGSGGVGQAGG----AGGSAGLIGIGGTGG-----AGGAG----
MUL_0572|M.ulcerans_Agy99 WGNGGNGGSGAAGQAGG----AGGAAGLIGTGGAGG-----MGGAGG---
TH_3810|M.thermoresistible__bu LSRGGDGGDGGLGGNGG----HGGGTGIISLLSLAG--------------
MAB_4284c|M.abscessus_ATCC_199 SGQGSTAVNGDVRDSNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADI
MAV_4827|M.avium_104 DVYKQQIRAESYGDAAG--QLSAMVAGLEKLESLPG----GLLLVGSGVD
MLBr_01556|M.leprae_Br4923 GGRPPRVGNNPFSSAQSVARPIPRPPAPRPSASPSSMSPRPGGAVGGGGP
. .
Mflv_5091|M.gilvum_PYR-GCK ---AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGG
Mvan_1264|M.vanbaalenii_PYR-1 ---VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGT
MSMEG_0868|M.smegmatis_MC2_155 GHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGG
MMAR_5135|M.marinum_M --ATGGTGGTGGLLWGN--GGIGGQGGTA-----MAGVNGGSPGHGGNGG
Rv2487c|M.tuberculosis_H37Rv --AAGGAGGNGGWLWGN--GGNGGVGGTS-----VAAGIGG---AGGNGG
Mb0896c|M.bovis_AF2122/97 --AVGGVGGNGGWLYGN--GGAGGLGGTG-----VAGVNGGMGAAGGAGG
MUL_0572|M.ulcerans_Agy99 --GAGGMGGSGGWLLGN--GGAGGAGGVG-----CAGVSGG---VGGTGG
TH_3810|M.thermoresistible__bu ---NGGNGGNGYRTTDNN-ALDGGHGGNG-----------------GNVG
MAB_4284c|M.abscessus_ATCC_199 DKSVTVVDDHSQRNTTNINDSFNTDRSTN---IGSGNTTNTEIGSHNQAN
MAV_4827|M.avium_104 VAPLKQVLQTTTFLDVSVAEEPETALARG-----AALAAANAPLFASSTA
MLBr_01556|M.leprae_Br4923 RPPRTGVPRPGGGRPGAPVGGRSDAGGGN-----YRGGGVGALPGGGSGG
Mflv_5091|M.gilvum_PYR-GCK LGETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGG
Mvan_1264|M.vanbaalenii_PYR-1 AGETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGG
MSMEG_0868|M.smegmatis_MC2_155 HSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGE
MMAR_5135|M.marinum_M NAFLFGDGGTGGQG--------------------GTGLAGADGVNPTPTG
Rv2487c|M.tuberculosis_H37Rv NAGLFGHGGAGGTG--------------------GAGLAGANGVNPTPGP
Mb0896c|M.bovis_AF2122/97 NAYLFGSGGAGGQG--------------------GMGAAGADGVNPTPTG
MUL_0572|M.ulcerans_Agy99 NAMLFGNGGAGGMG--------------------GAGADGAVGAAGTAGT
TH_3810|M.thermoresistible__bu FFSLFNLGGAGGWG--------------------GSGVDGVD--------
MAB_4284c|M.abscessus_ATCC_199 IGTSTSAGGSAAVG-------------------GNAGLAGNAGLAGNAGL
MAV_4827|M.avium_104 ALAYAQDPGTGAVD--------------------QYSLPDYLYVPVDPEP
MLBr_01556|M.leprae_Br4923 FRGRPGGGGHGGGGRP----------------GQRGGAAGAFGRPGGAPR
* .. . . .
Mflv_5091|M.gilvum_PYR-GCK AG----------STGAVGG-------VGGKG----IQGGQG---------
Mvan_1264|M.vanbaalenii_PYR-1 VG----------ATGGAGG-------VGGKG----IQGGQG---------
MSMEG_0868|M.smegmatis_MC2_155 IYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASG
MMAR_5135|M.marinum_M TA----------GTGAAG-----GNVSGNGP-------------------
Rv2487c|M.tuberculosis_H37Rv AA----------STGDSP-----ADVSGIGD-------------------
Mb0896c|M.bovis_AF2122/97 TA----------DAGSTG-----TDQTLGGN-------------------
MUL_0572|M.ulcerans_Agy99 ST----------SAGGVGGAGWDATAAGVLA-------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AG----------NAGLAGN----AGLAGNAG-------------------
MAV_4827|M.avium_104 GDDE-------LAYSAVGEEDAESPTVVIEK-------------------
MLBr_01556|M.leprae_Br4923 RGRKS------KRQKRQEYDSMQAPVVGGVR-------------------
Mflv_5091|M.gilvum_PYR-GCK ----LQGGKGGDGGAGGKGGDADSMGS------------------AGATG
Mvan_1264|M.vanbaalenii_PYR-1 ----LQGGQGGDGGTGGTGGDATSMGE------------------AGATG
MSMEG_0868|M.smegmatis_MC2_155 TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANG
MMAR_5135|M.marinum_M ----LTGGNGDTGDTGGTG----------------------------ETG
Rv2487c|M.tuberculosis_H37Rv ----QTGGDGGTGGHGTAGT---------------------------PTG
Mb0896c|M.bovis_AF2122/97 ----AIGGNGGPGDAGDAMT---------------------------SGG
MUL_0572|M.ulcerans_Agy99 ----ATGGDGGDSGGGGAGG---------------------------NGG
TH_3810|M.thermoresistible__bu ----VVGGNPDGGTPGAHG----------------------------ESH
MAB_4284c|M.abscessus_ATCC_199 ----LAGNAGLAGNAGLAGN-----------------------------A
MAV_4827|M.avium_104 -LFLPEDSEPRRRPVLLVGS---------------------------GLA
MLBr_01556|M.leprae_Br4923 ----LPHGNGETIRLARGASLSDFAEKIDANPAALVQALFNLGEMVTATQ
.
Mflv_5091|M.gilvum_PYR-GCK GKGGNGGNGGRGGLFG---------------KGGNAGNGAD---------
Mvan_1264|M.vanbaalenii_PYR-1 GKGGNGGNGGRGSLFG---------------RGGNAGNGGN---------
MSMEG_0868|M.smegmatis_MC2_155 AVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN
MMAR_5135|M.marinum_M GTGGAGG---SATASS------------GSATGGKGGAGGDP--------
Rv2487c|M.tuberculosis_H37Rv GTGGDGA---TATAGS------------GKATGGAGGDGGTA--------
Mb0896c|M.bovis_AF2122/97 AGGSGGN---AVSTVN------------GDAVGGEGGKGGE---------
MUL_0572|M.ulcerans_Agy99 AGGAGGHGSALFGADG------------ANGNGGAGGAGGNP--------
TH_3810|M.thermoresistible__bu TPGVYTD------------------------RQGEDGEDGTG--------
MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGNAGLAG---------------NAGLAGNAGLAG-------
MAV_4827|M.avium_104 VVGISAVLALEIALAIG------------IRTTGTVALQPTP--------
MLBr_01556|M.leprae_Br4923 SVGDETLELLGSEMNYN------------VQVVSPEDEDRELLEP-----
. .
Mflv_5091|M.gilvum_PYR-GCK -------------GGTGGAGGAGGTGG-TGGAG-------GTGG------
Mvan_1264|M.vanbaalenii_PYR-1 -------------GGTGGNGGNGGTGG-TGGNG-------GTGG------
MSMEG_0868|M.smegmatis_MC2_155 GPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRG-------GDGAGASVWK
MMAR_5135|M.marinum_M -----------GGGANGGAGGAGGDAESFSGQ--------AHGG------
Rv2487c|M.tuberculosis_H37Rv -----------AAGGGGGNGGDGGVAQGDIAS--------AFGG------
Mb0896c|M.bovis_AF2122/97 -------------GAYGGAGGAGGSAASIGNA--------AIGG------
MUL_0572|M.ulcerans_Agy99 -----------GAPGNGGTGGVGPDAATSGGMGGTGGDPGAVGGRGN---
TH_3810|M.thermoresistible__bu -------------TGIGGRGGNGGSSSGTHPMA-----------------
MAB_4284c|M.abscessus_ATCC_199 ------------NAGLAGNAGLAGNAGLAGNAG-----------------
MAV_4827|M.avium_104 -------------NQHLIVPTEQAPAPPPVQAS-----------------
MLBr_01556|M.leprae_Br4923 -----------FDLTYGEDQGDEDELQVRPPVVTVMGHVDHGKTR-----
Mflv_5091|M.gilvum_PYR-GCK -----------TGGTGGIGGAGSTGGTGG--TGGTGGTGGTGGTG-GTGG
Mvan_1264|M.vanbaalenii_PYR-1 -----------TGGTGGIGGAGSTGGTGG--TGGTGGTGGTGGTG-GTGG
MSMEG_0868|M.smegmatis_MC2_155 ANGQHSTGQTDTGGNGGRGGDGGTFVNAG--ANGNGGAGGAGGVSEGEGG
MMAR_5135|M.marinum_M -----------AGGDGSQGGIPGGS-------GGAGGDGG---KATGLAS
Rv2487c|M.tuberculosis_H37Rv -----------DGGNGSDGVAAGSG-------GGSGGAGGGAFVHIATAT
Mb0896c|M.bovis_AF2122/97 -----------NGGAGGNAQAPGGV-------GGAGGEGGDAQVGTNSPS
MUL_0572|M.ulcerans_Agy99 --------SGAAGGAGAVAGASGAAGTIIAGNGGNGGAGGAGYAADGPAG
TH_3810|M.thermoresistible__bu -----------EDGEHVKALD-----------GRPGLDGGNG--------
MAB_4284c|M.abscessus_ATCC_199 -----------LAGNAGLAGNAGLAGNAG-LAGNAGLAGNAAVAGNAAVA
MAV_4827|M.avium_104 -----------APQPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAPPLPE
MLBr_01556|M.leprae_Br4923 ------LLDTIRKANVREAEAGGITQHIGAYQVGVDLDGSERLITFIDTP
.
Mflv_5091|M.gilvum_PYR-GCK TG-GTGGTGGKGGTGGTGGAGGTG----GDGGTGGTGGTGGTG-------
Mvan_1264|M.vanbaalenii_PYR-1 TG-GTGGTGGKGGTGGTGGDGGTG----GTGGTGGTGGTGGTG-------
MSMEG_0868|M.smegmatis_MC2_155 TG-GHGGDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPS
MMAR_5135|M.marinum_M ---GIGGDGGDG------GRGFATDVSGGTAGGGGTGGDGGRGG-----L
Rv2487c|M.tuberculosis_H37Rv ---STGGSGGFG------GNGAASAASGADGGAGGAGGNGGAGG-----L
Mb0896c|M.bovis_AF2122/97 N--AEAGNGGSG------GNGFDSFASGGTGGAGGTGGAGGRGG-----L
MUL_0572|M.ulcerans_Agy99 PAIGNGGDGGHGGAGGFYGNGGAGGAGGNSAPGGGTGGNGGTGGD--SGA
TH_3810|M.thermoresistible__bu ---SHGGNGGHG----------------GRGGFLGIGGSGGWG-------
MAB_4284c|M.abscessus_ATCC_199 GNAAVAGNAAVGG-------------VLNTGVSGAIGGSSHVGG------
MAV_4827|M.avium_104 APPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQP
MLBr_01556|M.leprae_Br4923 GHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVA
.
Mflv_5091|M.gilvum_PYR-GCK --GTGGTGGTGGAG-----------DGTGGTGGTGG----TGGQGGQGGQ
Mvan_1264|M.vanbaalenii_PYR-1 --GTGGTGGTGGAG-----------DGLGGTGGTGG----TGGFGGQGGQ
MSMEG_0868|M.smegmatis_MC2_155 HTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGD
MMAR_5135|M.marinum_M LIGSGGNGGTGGTG------------GTGGTGAAAGVGGIGG-------D
Rv2487c|M.tuberculosis_H37Rv LFGDGGNGGAGGAG------------GIGGDGATGGPGGSGGNAGIARFD
Mb0896c|M.bovis_AF2122/97 LIGDGGAGGAGGVG------------GTGGSGAPGG--------------
MUL_0572|M.ulcerans_Agy99 MGSSGGRGGDGGVG------------TNGGAGGGGGNATSYGTANATGGA
TH_3810|M.thermoresistible__bu --GHGGNGGDTDAD--------------GGNGGDGG--------------
MAB_4284c|M.abscessus_ATCC_199 -AINESLGGSGSVG--------------GSTAVGGG--------------
MAV_4827|M.avium_104 VQPPVRVPQPPSPP------------QVGGTVPQSPP-------------
MLBr_01556|M.leprae_Br4923 VNKIDKEGADPAKIRG-------QLTEYGLVAEDFGGDTMFIDISAKVGT
*
Mflv_5091|M.gilvum_PYR-GCK GG-----------------TGGTGGQGG-LGGGGGTG-------------
Mvan_1264|M.vanbaalenii_PYR-1 GG-----------------TGGTGGQGG-LGGVGGTG-------------
MSMEG_0868|M.smegmatis_MC2_155 GGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQA
MMAR_5135|M.marinum_M GGDA---------TAASSATGGHGGDGGDSDPSVGTGGN-----------
Rv2487c|M.tuberculosis_H37Rv SPDP---------EAEPDVVGGKGGDGGKGGSGLGVGGA-----------
Mb0896c|M.bovis_AF2122/97 --------------------------------------------------
MUL_0572|M.ulcerans_Agy99 GGDG---------GTGSTGNGGSGGDGGNGGTGHGGGGGPGGTAINYGAG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 NIEALLEAVLLTADAALDLRANSGMEAQGVAIEAHLDRGR----------
Mflv_5091|M.gilvum_PYR-GCK ----------GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGD
Mvan_1264|M.vanbaalenii_PYR-1 ----------GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGD
MSMEG_0868|M.smegmatis_MC2_155 NPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGD
MMAR_5135|M.marinum_M ------------GGTGGNGGNGGAASLLF-------------GNGGSGGD
Rv2487c|M.tuberculosis_H37Rv ------------GGTGGAGGNGGAGGLLF-------------GNGGNGGN
Mb0896c|M.bovis_AF2122/97 --------------------------------------------GGAGGD
MUL_0572|M.ulcerans_Agy99 DAFGGAA---GKGGTGVVGGNGGSGGAAYNYGTGNAT-----GAGGSSGS
TH_3810|M.thermoresistible__bu -------------------------------------------NGGSAGR
MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------AHTGVGGG
MAV_4827|M.avium_104 ------------------------------------------QHQTPPGE
MLBr_01556|M.leprae_Br4923 ----------GPVATVLVQRGTLRIGDSVVAGDAYGRVRRMVDEHGVDIE
Mflv_5091|M.gilvum_PYR-GCK GGLG----------GLGGFGGSGGTGGQGGLGGPGG----------STGG
Mvan_1264|M.vanbaalenii_PYR-1 GGLG----------GLGGFGGVGGTGGQGGQGGPGG----------STGG
MSMEG_0868|M.smegmatis_MC2_155 GIDG----------GLGGNGGDGVVNTTANAANPGS----------ATGT
MMAR_5135|M.marinum_M GGVG----------GTGGTGGAGGSGAGGGVGGDGS----------SRGG
Rv2487c|M.tuberculosis_H37Rv AGAG----------GDGGAGVAGGVGGNGGGGGTATFHEDPVAGVWAVGG
Mb0896c|M.bovis_AF2122/97 GGAA----------NTDSAGSSRK----------------------AFGG
MUL_0572|M.ulcerans_Agy99 GGAASVPNSASTATATSGSGGAGGDGTDGGNGGSGGFAFTFGTG-NIIAG
TH_3810|M.thermoresistible__bu GGTG----------GLRG-----------------------------VFG
MAB_4284c|M.abscessus_ATCC_199 VSTG------------VGVGSHVGGGISESLGGSGS-----------VGG
MAV_4827|M.avium_104 GTPP----------KPDGPGNYGGGHVP-------------------TPG
MLBr_01556|M.leprae_Br4923 AALPSSPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRS-----ARKRN
.
Mflv_5091|M.gilvum_PYR-GCK AGGAGG--QAGTAGKGGLFG-------------GSGSAGKAGATGAAG--
Mvan_1264|M.vanbaalenii_PYR-1 AGGAGG--QAGVAGKGGLFG-------------GSGSAGTAGVTGASG--
MSMEG_0868|M.smegmatis_MC2_155 ATGGDGGKATGTASQGGNGGPSWV---------QSGYGSTLGGNATGT--
MMAR_5135|M.marinum_M IGGNGGSGANSMA-IGG----------------EGGVGGRGGDAGTSG--
Rv2487c|M.tuberculosis_H37Rv VGGDGGSGGSSLG-VGG----------------VGGAGGVGGKGGASG--
Mb0896c|M.bovis_AF2122/97 DGGVGGDGASALG-TGG----------------EGGIGGQGGNGGAGG--
MUL_0572|M.ulcerans_Agy99 VGGGGGTGSTGVGGIGGSGGGADINNGAFTVVPQGGAGGHGGDGATDGGA
TH_3810|M.thermoresistible__bu INGGNG---------------------------RAGLGGRGXXXXGGG--
MAB_4284c|M.abscessus_ATCC_199 STAVGGGAHTGVG--------------------GGVSTGVGVGSHVGGG-
MAV_4827|M.avium_104 AGGSGGSGGGHVP--------------------TPGAGGSGGSGGG----
MLBr_01556|M.leprae_Br4923 ALAARSRKRISLEDLDSALKETSQLN----LILKGDNAGTVEALEEALMG
. . .
Mflv_5091|M.gilvum_PYR-GCK --------------ASGGKGAQGATGAQGATG------AQGATG-ATGAA
Mvan_1264|M.vanbaalenii_PYR-1 --------------ASGGKGAQGATGAQGATG------AQGATG-ATGAS
MSMEG_0868|M.smegmatis_MC2_155 --------------ATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNT
MMAR_5135|M.marinum_M --------------LLIGNGGDGGSGGAGGTG------------------
Rv2487c|M.tuberculosis_H37Rv --------------MLIGNGGNGGSGGVGGAG------------------
Mb0896c|M.bovis_AF2122/97 --------------LLIGNGGAGGVGGTAGAG------------------
MUL_0572|M.ulcerans_Agy99 GGAGGFTEIDSSASVIAATGGAGGDGGSGGTGR-----------------
TH_3810|M.thermoresistible__bu ----------------VGAAVRSGNGVFSGGG------------------
MAB_4284c|M.abscessus_ATCC_199 --------------ISESLGGSGSVGGSTAVG------------------
MAV_4827|M.avium_104 ---------------HVPTPGTGGPGGTGGSG------------------
MLBr_01556|M.leprae_Br4923 ---------IQVDDEVALRVIDRGVGGITETNVN----------------
. * .
Mflv_5091|M.gilvum_PYR-GCK GKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGS
Mvan_1264|M.vanbaalenii_PYR-1 GAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGS
MSMEG_0868|M.smegmatis_MC2_155 ATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGG
MMAR_5135|M.marinum_M ---GTGGAG-GAGAAGGAGG--------NGST---QIAFGGDGGNGGDGG
Rv2487c|M.tuberculosis_H37Rv ---GVGGAG-GDGGNGGSGG--------NASTFGDENSIGGAGGTGGNGG
Mb0896c|M.bovis_AF2122/97 ---GTGGSG-GAGGAGGAGG--------GGTN------SGPGAAFGGNGN
MUL_0572|M.ulcerans_Agy99 --GGTGGGGTGGGGTGGGGG--------VGINNGSGEAIGGAPGAGGTGA
TH_3810|M.thermoresistible__bu ---GTPSAGFGVPTT-----------------------IQFPAGSCTSRA
MAB_4284c|M.abscessus_ATCC_199 ---GGAHTGVGGGVNTGVGVG-------------SHVGGGISESLGGSGS
MAV_4827|M.avium_104 ---GGHVPTPGAGTPGGSGG-------------------GHLPFPGAGST
MLBr_01556|M.leprae_Br4923 --LASASDAIIIGFNVRAEGKATELASREGVEIRYYLVIYQAIDDIEKAL
.
Mflv_5091|M.gilvum_PYR-GCK QGAAGKAGATGTTGATG---------------AAGEDGDAGSGGSG-ING
Mvan_1264|M.vanbaalenii_PYR-1 QGAAGKAGATGTTGATG---------------AAGDAGDPGSEAVD-ING
MSMEG_0868|M.smegmatis_MC2_155 KGADGWVQAYDPAGPVGS-------KIANSSAVAGNGGDGGVNGTGGASG
MMAR_5135|M.marinum_M DGAQG-----GEGGATG--------------------SVGGIGSQGGILF
Rv2487c|M.tuberculosis_H37Rv NGANG-----GNGGAGG--------------------IAGGAGGSGGFLS
Mb0896c|M.bovis_AF2122/97 TGGNG-----GNGGAPG--------------------ALGGKGGSGGLIG
MUL_0572|M.ulcerans_Agy99 VGGDG-----GQGGAAYSYGTGDATGSAGAAGTAGTTGVGGTGGAGGAAY
TH_3810|M.thermoresistible__bu VSREG------------------------------------IMPSSRAAS
MAB_4284c|M.abscessus_ATCC_199 VGGSTAVGGGAHTSAIN-------------------DALGGSGSVGGSTA
MAV_4827|M.avium_104 PGGSG-------------------------------GGHLPTPGAGTPGG
MLBr_01556|M.leprae_Br4923 RGMLKPIYEENQLGRAEIR------------------ALFRSSKVGIIAG
. .
Mflv_5091|M.gilvum_PYR-GCK GAGGAGG-----------AGGEGGEGGDGGKGGAGAE-------------
Mvan_1264|M.vanbaalenii_PYR-1 GAGGAGG-----------AGGEGGEGGAGGAGGDGSE-------------
MSMEG_0868|M.smegmatis_MC2_155 GDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGA-----
MMAR_5135|M.marinum_M SHAGADG-----------STGAPGAGGAGGAGGAA---------------
Rv2487c|M.tuberculosis_H37Rv GAAGVSG-----------ADGIGGAGGAGGAGGAG---------------
Mb0896c|M.bovis_AF2122/97 -RAGSDG-----------GVGAGGAGGAGGAGGTG---------------
MUL_0572|M.ulcerans_Agy99 TLNGAST-----------ATATGGIGGNGGDGGTANGSNGGNGGAGGYAS
TH_3810|M.thermoresistible__bu ARAGAAC-----------ASSTSRSRRSFCCSRA----------------
MAB_4284c|M.abscessus_ATCC_199 VGGGAHTS----------AINESMNSSINASHSSSMNESFG---------
MAV_4827|M.avium_104 GLGGFGG-----------GHAPAPGGGLGGGGGHAPAP------------
MLBr_01556|M.leprae_Br4923 CIISSGVVRRN-------AKVRLLRDNIVVTDNLTVTS------------
. .
Mflv_5091|M.gilvum_PYR-GCK --------GGAGGGGGAGGSGAGGAG-----------------GAGGSGG
Mvan_1264|M.vanbaalenii_PYR-1 --------GGAGGSGGAGGSGTGGAG-----------------GAGGSGG
MSMEG_0868|M.smegmatis_MC2_155 --------GGAGGNGGTGGTTAGGSGNG---------------GNGGNGG
MMAR_5135|M.marinum_M ---------GGFGAGGSGATAGA----------------------DGKAG
Rv2487c|M.tuberculosis_H37Rv ---------GSGGEAGAGGLTNG----------------------PGSPG
Mb0896c|M.bovis_AF2122/97 ---------GEGGTGGDGKTTDGN---------------------PGMGG
MUL_0572|M.ulcerans_Agy99 TTGTGTASVGNGGRGGDGTATVATGGTGGVGGNAHAPAGSPVPGVGGKGG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------SSMGSHGAAGTGFEAQG--------------------HAQGHAS
MAV_4827|M.avium_104 ----------GGGLGGFG----------------------------GGHS
MLBr_01556|M.leprae_Br4923 ---------LRREKDDVTEVREGFECG----------------MTLGYSD
Mflv_5091|M.gilvum_PYR-GCK SGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1 SGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155 NGGADGTPGTAGTTGANNP
MMAR_5135|M.marinum_M TAGTAGATGPHG-------
Rv2487c|M.tuberculosis_H37Rv VSGTEGMAGAPG-------
Mb0896c|M.bovis_AF2122/97 SPGSAGQPGQPG-------
MUL_0572|M.ulcerans_Agy99 NPGPGGKPGPNGADGIVV-
TH_3810|M.thermoresistible__bu -------------------
MAB_4284c|M.abscessus_ATCC_199 ETAHTTLPGAEHH------
MAV_4827|M.avium_104 GGGLGGLGGGHK-------
MLBr_01556|M.leprae_Br4923 IKEGDVIESYELVEKQRA-